Patents and Patent Applications from University of Notre Dame


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US20180193803 COPOLYMER NANOFILTERS WITH CHARGE-PATTERNED DOMAINS  
The further advancement of membrane separation processes requires the development of more selective membranes. In this study, membranes that take inspiration from biological systems and use...
US20180179157 IONIC LIQUIDS COMPRISING HETERAROMATIC ANIONS  
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally...
US20180177810 MULTIFUNCTIONAL MICELLAR NANOPARTICLE-BASED DRUG AND TARGETING AGENT SYSTEM  
Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component...
9975121 Microfluidic devices, systems, and methods for evaluating tissue samples  
A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can...
US20180136163 METHODS AND APPARATUS FOR A SHEAR-ENHANCED CNT-ASSEMBLY NANOSENSOR PLATFORM FOR ULTRA-SENSITIVE AND SELECTIVE PROTEIN DETECTION  
A nanoscale protein-sensing platform with a non-equilibrium on-off switch that employs dielectrophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversible...
9972120 Systems and methods for geometrically mapping two-dimensional images to three-dimensional surfaces  
A method of mapping a two-dimensional image to a three-dimensional surface includes capturing data for a two-dimensional image and a three-dimensional structure. A process determines coincident...
US20180127979 MODULAR TRUSS JOINT  
A new approach for modular construction is a type of connection that can be used to form structures of different depths and/or variable-depth structures. Advantages of this approach include...
9954085 Group III-Nitride compound heterojunction tunnel field-effect transistors and methods for making the same  
A tunnel field-effect transistor device includes a p-type GaN source layer, an ntype GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. These devices...
9951035 Selective matrix metalloproteinase inhibitors  
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be...
9951008 Ionic liquids comprising heteraromatic anions  
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally...
9936763 Methods and apparatus for human motion controlled wearable refrigeration  
A wearable, portable, self-contained refrigeration/cooling garment may effectively convert the energy of human movement into heat flux. The heat flux can then used to actively control the...
US20180088080 METHODS AND APPARATUS FOR MITIGATION OF CURRENT REVERSAL IN CAPILLARY ZONE ELECTROPHORESIS-ELECTROSPRAY DEVICE  
The combined capillary electrophoresis electrospray mass spectrometry apparatus has a circuit to handle excess current allows separations under a wide range of electrophoretic conditions. The...
9908876 Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same  
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various...
US20180057510 Synthesis and Utility of New Capgroup Largazole Analogs  
Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions...
9905647 Group III-nitride compound heterojunction tunnel field-effect transistors and methods for making the same  
A tunnel field-effect transistor device includes a p-type GaN source layer, an n-type GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. In one example,...
9899480 Single transistor random access memory using ion storage in two-dimensional crystals  
A single-transistor random access memory (RAM) cell may be used as universal memory. The single-transistor RAM cell generally includes a first gate, a 2D-crystal channel, a source, a drain, an ion...
US20180044376 Method for Preparing Largazole Analogs and Uses Thereof  
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally...
US20180044316 POTENTIATORS OF BETA-LACTAM ANTIBIOTICS  
We disclose herein that the BlaR1 protein of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, is phosphorylated on exposure to β-lactam antibiotics. This...
US20180031013 METHOD AND APPARATUS OF PLASMA FLOW CONTROL FOR DRAG REDUCTION  
A plasma plate is used to minimize drag of a fluid flow over an exposed surface. The plasma plate includes a series of plasma actuators positioned on the surface. Each plasma actuator is made of a...
US20180029997 QUINAZOLINONE ANTIBIOTICS  
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the...
9872870 Multifunctional micellar nanoparticle-based drug and targeting agent system  
Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component...
9867805 Gelatinase inhibitors and prodrugs  
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder,...
9862680 Peripherally substituted monocyclic beta-lactams  
The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.
9857316 Methods and apparatus for electromagnetic signal polarimetry sensing  
A system and method of identifying changes utilizing radio frequency polarization includes receiving a reflected and/or transmitted polarized radio frequency signal at a receiver, filtering,...
9856518 Method and apparatus for a nanopipette biosensor  
A nanopipette biosensor capable of detecting a small concentration of target molecules within a sample solution using optical detection methods. The biosensor includes a nanopipette that connects...
US20170363576 SYSTEM FOR CAPILLARY ELECTROPHORESIS FOR PEPTIDE AND PROTEIN ANALYSIS  
The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator,...
9848485 Methods and apparatus for pulsed-DC dielectric barrier discharge plasma actuator and circuit  
A plasma generating device intended to induce a flow in a fluid via plasma generation includes a dielectric separating two electrodes and a power supply. The first electrode is exposed to a fluid...
US20170355671 PERIPHERALLY SUBSTITUTED MONOCYCLIC BETA-LACTAMS  
The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.
US20170353210 ENHANCED COSITE TRANSMITTER-RECEIVER ISOLATION  
Systems and methods for improving isolation between a cosite transmitter-receiver system. The transmitter may send a first plurality of transmit signals from multiple transmit ports. The first...
9834301 Method of increasing the performance of aircraft, missiles, munitions and ground vehicles with plasma actuators  
A method of increasing the performance of an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly of controlling fluid flow across their surfaces or other...
US20170338874 LINEAR COMBINATIONS OF TRANSMIT SIGNALS BY A RECEIVER  
A multi-port transmitter can synthesize and send a first plurality of transmit signals having a separability characteristic which permits them to be differentiated from one another. A receiver can...
US20170333524 MOLECULAR CONSTRUCTS AND USES THEREOF  
Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and...
9825132 Systems and methods for filtering and computation using tunneling transistors  
An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (TFETs) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of...
US20170325932 ADDITIVE MANUFACTURING DEVICE FOR BIOMATERIALS  
An additive manufacturing (AM) device for biomaterials comprises a reservoir, a shaft, and a material delivery head. The device can be used for intracorporeal additive manufacturing. Material...
US20170312066 VERSATILE INHALATION ANESTHESIA PLATFORM FOR SMALL ANIMAL SURGERY  
A small animal bed for use with small animal subjects for sedatation during experimental procedures. In some embodiments, the bed uses flow of heated air through the bed to keep the small animal...
9804093 Ultrasensitive SERS flow detector  
The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection...
US20170298346 Dnazyme-nanoparticle conjugates and methods of use thereof  
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic...
US20170283877 BIOMARKERS AND USES THEREOF IN PROGNOSIS AND TREATMENT STRATEGIES FOR RIGHT-SIDE COLON CANCER DISEASE AND LEFT-SIDE COLON CANCER DISEASE  
Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such...
9776975 Quinazolinone antibiotics  
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the...
US20170274053 ACCELERATION OF DIABETIC WOUND HEALING  
The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with...
US20170269035 VOLTAMMETRY IN HIGH-VOLTAGE FIELDS  
Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a...
US20170268186 ADJUSTABLE BOLTED STEEL PLATE CONNECTION  
An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through...
US20170268185 ADJUSTABLE CONNECTION FOR STRUCTURAL MEMBERS  
An adjustable structural connection—a connection which can be adjusted to alter the location and angle of member attachment—transforms the traditional notion of connections as a static means of...
US20170253916 EXOSOMAL BIOMARKERS DIAGNOSTIC OF TUBERCULOSIS  
The disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily...
US20170248640 METHODS AND APPARATUS FOR SPIN WAVE-BASED SPECTRUM ANALYZERS  
An example device includes a magnetic film, two or more spin wave generators, and one or more detectors. The magnetic film is capable of supporting spin waves. The two or more spin wave generators...
US20170247766 LATE ER+ BREAST CANCER ONSET ASSESSMENT AND TREATMENT SELECTION  
A method for determining the likelihood of late ER− breast cancer disease relapse/recurrence is disclosed. Late ER+ breast cancer disease onset and/or recurrence is determined for a period of 5 to...
US20170229737 ION TRANSPORT IN BINARY-SALT IONIC LIQUIDS  
The viscosity of various ionic liquids (IL), the solvent tetraethylene glycol dimethyl ether (G4), and their mixtures, with or without lithium salts, were measured experimentally. Various...
US20170229416 Inter-Chip Alignment  
First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an...
US20170224799 IDENTIFICATION OF IMMUNOLOGICALLY PROTECTIVE NEO-EPITOPES FOR THE TREATMENT OF CANCERS  
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques....
9721067 Accelerated progression relapse test  
An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a...