Patents and Patent Applications from University of Notre Dame


Match Document Document Title
US20190328896 SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS  
A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group...
10457716 Protein folding and methods of using same  
The instant disclosure provides a microscale method for providing correctly folded, and assembled biologically active proteins in an efficient and shorted time frame, compared to conventional...
US20190304098 SEGMENTING ULTRASOUND IMAGES  
Optimizations are provided for segmenting tissue objects included in an ultrasound image. Initially, raw pixel data is received. Here, each pixel corresponds to ultrasound information. This raw...
US20190297879 RNAi Insecticide Materials and Methods  
The present invention provides a novel class of insecticides for control of disease vector insects, particularly mosquitoes. These insecticides prevent maturation or development of larvae into...
US20190296661 ELECTRICITY GENERATION FROM LOW GRADE WASTE HEAT  
Systems and methods for generating electricity from low grade heat. The system and method may be a closed loop. When a liquid mixture of salt, water, and an ion-stripping liquid is heated using...
US20190285627 PATHOGEN DETECTION BY STRAIN-SPECIFIC BACTERIAL RECOGNITION AND PLASMONIC AMPLIFICATION AND READOUT  
The present invention relates to a method and kit for detecting bacteria in a sample. Substrate having a surface comprising an interdigitated Au electrode array and a plurality of siderophores...
10416115 System for capillary electrophoresis for peptide and protein analysis  
A method of coating the inside wall of a capillary with a polymeric material for capillary electrophoresis is disclosed. The method can include introducing a catalyst-free solution of a monomer...
10413517 Composition and method for the treatment of neurological diseases and cerebral injury  
Methods and compositions which include or include the administration of a hydrophobic drug, prodrug thereof, salt thereof, isoform thereof, or a combination thereof; cyclodextrin, prodrug thereof,...
10410989 Inter-chip alignment  
First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an...
US20190271619 SIMULTANEOUS ISOLATION AND PRECONCENTRATION OF EXOSOMES BY ION CONCENTRATION POLARIZATION METHOD AND APPARATUS  
Exosomes carry microRNA biomarkers, occur in higher abundance in cancerous patients than in healthy ones, and because they are present in most biofluids, including blood and urine, can be obtained...
10385251 Compounds, complexes, compositions, methods and systems for heating and cooling  
Disclosed herein are ionic liquid compounds, complexes and compositions suitable for use as refrigerants. Methods and systems for heating and/or cooling, including vapor compression heating or...
10383002 Systems and methods for rapidly estimating available bandwidth in a WiFi link  
Systems and methods for determining an available bandwidth in a WiFi link using frame aggregation. One system includes an electronic processor configured to send a request for a probe sequence...
10370805 Adjustable bolted steel plate connection  
An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through...
10357546 Acceleration of diabetic wound healing  
The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with...
US20190210984 COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION  
Clostridium difficile infection (CDI) is a public health threat that results in 14,000 annual deaths in the United States. Challenges involve the production of CDI spores that can remain dormant...
10342846 Nanoparticle drug delivery systems  
The invention provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes or micelles that contain one or more targeting peptides and/or...
10329262 Quinazolinone antibiotics  
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed (Formula V). Compounds of this class can impair cell-wall biosynthesis by binding to...
US20190185528 TRANSGENIC SILKWORMS CAPABLE OF PRODUCING CHIMERIC SPIDER SILK POLYPEPTIDES AND FIBERS  
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes...
US20190180481 TOMOGRAPHIC RECONSTRUCTION WITH WEIGHTS  
An iterative reconstruction approach is provided that allows the use of differing weights in pixels or larger sub-regions in the reconstructed image. By way of example, the relative significance...
US20190178807 CLOSED BIPOLAR ELECTRODE-ENABLED ELECTROCHROMIC DETECTOR FOR CHEMICAL SENSING  
The described BPE-enabled device includes two separated chambers which perform detection and reporting independently. Analytical reaction of a target molecule in the analytical cell is coupled to...
US20190173537 MITIGATING BEAM SQUINT IN MILLIMETER WAVE WIRELESS COMMUNICATION SYSTEMS  
A method for managing beam squint in a phased antenna array system operating at millimeter wavelengths using carrier aggregation includes determining a minimum array gain threshold, determining an...
US20190167610 Triple Combination Formulation for Treatment of Chronic Pain  
The disclosure relates to use of a triple formulation comprising a histone deacytlase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.
US20190153047 TRANSGENIC SILKWORMS CAPABLE OF PRODUCING CHIMERIC SPIDER SILK POLYPEPTIDES AND FIBERS  
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes...
US20190148584 LIGHT EMITTING DIODES USING ULTRA-THIN QUANTUM HETEROSTRUCTURES  
A DUV-LED including a bottom substrate, a n-contact/injection layer formed on the bottom substrate, a p-contact region, and an emitting active region between the n-contact/injection layer and the...
US20190147972 BIOMOLECULE DESIGN MODEL AND USES THEREOF  
Disclosed are computational modeling methods employing RMS fluctuation values associated with energy functions to compute binding properties of a subject biomolecule and an identified target. An...
10287578 DNAzyme-nanoparticle conjugates and methods of use thereof  
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic...
10280787 Monitoring rotating machinery using radio frequency probes  
Systems and methods for monitoring rotating machinery are disclosed. Transmitter and receiver antennas can be provided with access to the rotating machinery. At least one receiver signal resulting...
US20190127340 NON-BETA LACTAM ANTIBIOTICS  
The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the...
10273522 Rapid detection of viable bacteria system and method  
An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a...
10270547 Method and apparatus for sinusoid detection  
A system and method for detection of complex sinusoidal signals. The method can include obtaining a set of complex-valued samples of one or more signals, in the presence of unknown noise, using a...
10264525 Energy efficient communications  
Systems and methods for performing energy efficient communication. A transceiver for use in a point-to-point packet-based communication link with packet erasures is described. The transceiver can...
10259788 Ionic liquids comprising heteraromatic anions  
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally...
US20190108441 IMAGE GENERATION USING MACHINE LEARNING  
The present approach relates to the training of a machine learning algorithm for image generation and use of such a trained algorithm for image generation. Training the machine learning algorithm...
US20190106467 CHIMERIC SPIDER SILK AND METHODS OF USE THEREOF  
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes...
10253013 Selective matrix metalloproteinase inhibitors  
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be...
10247720 Integrated membrane sensor for rapid molecular detection  
Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic...
US20190064110 A PICOMETER-DIAMETER PORE IN AN INORGANIC MEMBRANE FOR SEQUENCING PROTEIN  
Disclosed are thin inorganic membranes having a defined topography that includes pores having a defined diameter of nanometer and sub-nanometer diameter. The thin membranes are resistant to...
US20190031608 IONIC LIQUIDS COMPRISING HETERAROMATIC ANIONS  
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally...
10190271 Adjustable modules for variable depth structures  
A structural plane is presented for forming a variable depth structure constructed of adjustable modules. Each module is formed of four links connected with revolute joints. The modules are...
US20190016909 TEMPLATE SYNTHESIS OF POLYMERIC NANOMATERIALS BY INK-JET PRINTING  
A method for fabricating nanostructured polymeric materials based on a combination of inkjet printing and template synthesis. Layer-by-layer assembled nanotubes can be synthesized in a...
US20190011342 PARTICLE SIZE PURIFICATION METHOD AND DEVICES  
A panicle separation multi-membrane matrix device and method are provided. The particles isolated may comprise noun-scale particles, such extracellular membrane vesicles, having a size of about 50...
10174382 Breast cancer prognostication and screening kits and methods of using same  
A genetic biomarker panel is provided for prognosing late onset ER+ breast cancer relapse, in a breast cancer survivor patient. Kits are also provided for measuring levels or the presence of an...
US20190004010 ONE-STEP CAPILLARY ISOELECTRIC FOCUSING AND MOBILIZATION OF ANALYTES  
The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically...
US20190002914 METHODS AND COMPOSITIONS FOR TRANSPOSITION USING MINIMAL SEGMENTS OF THE EUKARYOTIC TRANSFORMATION VECTOR PIGGYBAC  
Isolated nucleic acid molecules that include a minimally-sized, functional (minimally-functional) piggyBac transposon can incorporate (i) a 5′ internal domain (ID) comprising a nucleotide fragment...
10168259 Microfluidic devices, systems, and methods for imaging tissue samples  
One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel....
US20180363054 METHOD FOR FORENSIC ANALYSIS OF SEXUAL ASSAULT  
Current procedures for the analysis of sexual assault kits are labor intensive, time consuming and deliver a success rate lower than 40%. This has resulted in rape kit backlogs of thousands. The...
US20180354944 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME  
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various...
US20180346975 ULTRA-SENSITIVE MULTI-TARGET LATERAL FLOW MOLECULAR ASSAY WITH FIELD-INDUCED PRECIPITATION  
Described are methods for detecting and quantifying biomolecules such as polynucleotides or polypeptides in an electrophoresis matrix using ion concentration polarization and nanoparticle aggregation.
10121245 Identification of inflammation in tissue images  
Systems and methods are provided for identifying markers for inflammation in a tissue image. The tissue image is captured as an image of a histology slide. Subcellular structures in the tissue...
US20180317131 Systems and Methods for Rapidly Estimating Available Bandwidth in a WiFi link  
Systems and methods for determining an available bandwidth in a WiFi link using frame aggregation. One system includes an electronic processor configured to send a request for a probe sequence...