Patents and Patent Applications from University of Notre Dame


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US20170355671 PERIPHERALLY SUBSTITUTED MONOCYCLIC BETA-LACTAMS  
The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.
US20170353210 ENHANCED COSITE TRANSMITTER-RECEIVER ISOLATION  
Systems and methods for improving isolation between a cosite transmitter-receiver system. The transmitter may send a first plurality of transmit signals from multiple transmit ports. The first...
9834301 Method of increasing the performance of aircraft, missiles, munitions and ground vehicles with plasma actuators  
A method of increasing the performance of an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly of controlling fluid flow across their surfaces or other...
US20170338874 LINEAR COMBINATIONS OF TRANSMIT SIGNALS BY A RECEIVER  
A multi-port transmitter can synthesize and send a first plurality of transmit signals having a separability characteristic which permits them to be differentiated from one another. A receiver can...
US20170333524 MOLECULAR CONSTRUCTS AND USES THEREOF  
Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and...
9825132 Systems and methods for filtering and computation using tunneling transistors  
An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (TFETs) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of...
US20170325932 ADDITIVE MANUFACTURING DEVICE FOR BIOMATERIALS  
An additive manufacturing (AM) device for biomaterials comprises a reservoir, a shaft, and a material delivery head. The device can be used for intracorporeal additive manufacturing. Material...
US20170312066 VERSATILE INHALATION ANESTHESIA PLATFORM FOR SMALL ANIMAL SURGERY  
A small animal bed for use with small animal subjects for sedatation during experimental procedures. In some embodiments, the bed uses flow of heated air through the bed to keep the small animal...
9804093 Ultrasensitive SERS flow detector  
The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection...
US20170298346 Dnazyme-nanoparticle conjugates and methods of use thereof  
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic...
US20170283877 BIOMARKERS AND USES THEREOF IN PROGNOSIS AND TREATMENT STRATEGIES FOR RIGHT-SIDE COLON CANCER DISEASE AND LEFT-SIDE COLON CANCER DISEASE  
Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such...
9776975 Quinazolinone antibiotics  
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the...
US20170274053 ACCELERATION OF DIABETIC WOUND HEALING  
The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with...
US20170269035 VOLTAMMETRY IN HIGH-VOLTAGE FIELDS  
Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a...
US20170268186 ADJUSTABLE BOLTED STEEL PLATE CONNECTION  
An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through...
US20170268185 ADJUSTABLE CONNECTION FOR STRUCTURAL MEMBERS  
An adjustable structural connection—a connection which can be adjusted to alter the location and angle of member attachment—transforms the traditional notion of connections as a static means of...
US20170253916 EXOSOMAL BIOMARKERS DIAGNOSTIC OF TUBERCULOSIS  
The disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily...
US20170248640 METHODS AND APPARATUS FOR SPIN WAVE-BASED SPECTRUM ANALYZERS  
An example device includes a magnetic film, two or more spin wave generators, and one or more detectors. The magnetic film is capable of supporting spin waves. The two or more spin wave generators...
US20170247766 LATE ER+ BREAST CANCER ONSET ASSESSMENT AND TREATMENT SELECTION  
A method for determining the likelihood of late ER− breast cancer disease relapse/recurrence is disclosed. Late ER+ breast cancer disease onset and/or recurrence is determined for a period of 5 to...
US20170229737 ION TRANSPORT IN BINARY-SALT IONIC LIQUIDS  
The viscosity of various ionic liquids (IL), the solvent tetraethylene glycol dimethyl ether (G4), and their mixtures, with or without lithium salts, were measured experimentally. Various...
US20170229416 Inter-Chip Alignment  
First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an...
US20170224799 IDENTIFICATION OF IMMUNOLOGICALLY PROTECTIVE NEO-EPITOPES FOR THE TREATMENT OF CANCERS  
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques....
9721067 Accelerated progression relapse test  
An Accelerated Progression Relapse Test (APRT) and method is provided for use in the prognosis of a patient having an ER+ breast cancer. The APRT provides a determination of when a patient in a...
9717758 High-affinity DMF5 T cell receptor (TCR) variants  
High-affinity variants of the DMF5 TCR, and methods of use thereof for the treatment and imaging of cancer in a patient.
9712146 Mixed signal processors  
Various processor architectures for mixed signal computation exploit the unique characteristics of advanced CMOS technologies, such as fin-based, multi-gate field effect transistors, and/or...
9708339 1,3-benzothiazinone, sulfoxide, and sulfone compounds with electrophilic substituent  
A compound, having the following formula: or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein E includes an electrophilic site, and wherein R1-R4 and...
9707257 Anti-HIV group I introns and uses thereof in treating HIV infections  
Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone...
US20170190685 SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS  
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be...
US20170181260 METHODS AND APPARATUS FOR PULSED-DC DIELECTRIC BARRIER DISCHARGE PLASMA ACTUATOR AND CIRCUIT  
A plasma generating device intended to induce a flow in a fluid via plasma generation includes a dielectric separating two electrodes and a power supply. The first electrode is exposed to a fluid...
US20170179093 Inter-Chip Alignment  
First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is...
US20170166890 Dnazyme-nanoparticle conjugates and methods of use thereof  
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic...
US20170166607 ANTIBODY PURIFICATION VIA AFFINITY CHROMATOGRAPHY  
Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids,...
9657336 Systems and methods for detecting and quantifying a sequence of nucleotides  
Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nanoparticle. In particular, the examples include functionalizing a plurality of...
US20170131335 COHERENT SIGNAL ANALYZER  
Systems and methods for analyzing a characteristic of a transmitter, a receiver, or a propagation channel are disclosed. At least one receiver signal resulting from at least one transmitter signal...
US20170125555 GROUP III-NITRIDE COMPOUND HETEROJUNCTION TUNNEL FIELD-EFFECT TRANSISTORS AND METHODS FOR MAKING THE SAME  
A tunnel field-effect transistor device includes a p-type GaN source layer, an ntype GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. These devices...
US20170125521 GROUP III-NITRIDE COMPOUND HETEROJUNCTION TUNNEL FIELD-EFFECT TRANSISTORS AND METHODS FOR MAKING THE SAME  
A tunnel field-effect transistor device includes a p-type GaN source layer, an n-type GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. In one example,...
9633976 Systems and methods for inter-chip communication  
A quilt packaging system includes a first and second electronic device each comprising a plurality of edge surfaces at least a first edge surface of which comprises one or more interconnect...
US20170108485 INTEGRATED MEMBRANE SENSOR FOR RAPID MOLECULAR DETECTION  
Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic...
US20170103979 SYSTEMS AND METHODS FOR FILTERING AND COMPUTATION USING TUNNELLING TRANSISTORS  
An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (TFETs) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of...
US20170101748 Adjustable Modules for Variable Depth Structures  
This disclosure presents a new strategy for modular construction: an adjustable module. This disclosure develops a new adjustable module comprised of a four-bar linkage which can form more...
9620473 Quilt packaging system with interdigitated interconnecting nodules for inter-chip alignment  
First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is...
9617249 Benzoheterocyclic anti-bacterial agents  
Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to...
US20170098716 TWO-DIMENSIONAL HETEROJUNCTION INTERLAYER TUNNELING FIELD EFFECT TRANSISTORS  
A two-dimensional (2D) heterojunction interlayer tunneling field effect transistor (Thin-TFET) allows for particle tunneling in a vertical stack comprising monolayers of two-dimensional...
9605002 5,5-heteroaromatic anti-infective compounds  
The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods...
9604957 Selective matrix metalloproteinase inhibitors  
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be...
US20170085255 MIXED SIGNAL PROCESSORS  
Various processor architectures for mixed signal computation exploit the unique characteristics of advanced CMOS technologies, such as fin-based, multi-gate field effect transistors, and/or...
9598460 Antibody purification via affinity chromatography  
Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids,...
US20170076448 IDENTIFICATION OF INFLAMMATION IN TISSUE IMAGES  
Systems and methods are provided for identifying markers for inflammation in a tissue image. The tissue image is captured as an image of a histology slide. Subcellular structures in the tissue...
9592490 Glass catalysts for soot combustion and methods of manufacturing the same  
A simplified method of manufacturing a catalyst for soot combustion includes the synthesis of a catalyst composition. A substrate is prepared for receipt of the composition and a sol solution is...
US20170069860 CELL-BASED ELECTROMECHANICAL BIOCOMPUTING  
A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.