Patents and Patent Applications from University of North Carolina


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US20170301527 SOLID PHASE EXTRACTION WITH CAPILLARY ELECTROPHORESIS  
Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer....
US20170298414 MOLECULAR DIAGNOSIS AND TYPING OF LUNG CANCER VARIANTS  
Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample....
9792715 Methods, systems, and computer readable media for utilizing synthetic animatronics  
Methods, systems, and computer readable media for utilizing synthetic animatronics are disclosed. According to one aspect, a method for synthetic animatronics includes providing a display surface...
9791618 Waveguides incorporating novel metamaterials and associated methods of manufacture  
A hollow-core waveguide structure for guiding an electromagnetic signal, comprising: a core material comprising a predetermined refractive index; and a cladding structure disposed about the core...
9791265 Methods of determining the shape of a sessile drop  
In one aspect, methods of determining the shape of a sessile drop are described herein. In some embodiments, a method described herein comprises measuring a first shape parameter of a sessile drop...
9782769 Light beam guided liquid delivery device  
A light beam guided liquid delivery device, including: a liquid delivery device; a light beam generator; and a bracket coupling the light beam generator to the liquid delivery device such that a...
9782136 Intraoral tomosynthesis systems, methods, and computer readable media for dental imaging  
Intraoral tomosynthesis systems, methods, and computer readable media for dental imaging can include an x-ray source containing multiple focal spots spatially distributed on one or multiple anodes...
US20170287353 ALCOHOL AND DRUG INTERVENTION SYSTEM AND METHOD  
An alcohol and drug intervention system and method, comprising: a server component; and a mobile application component wirelessly coupled to the server component; wherein the server component and...
US20170274024 AAV Vectors Targeted to Oligodendrocytes  
The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.
9771330 Pyrimidine compounds for the treatment of cancer  
Compounds of Formula I or II: are described, along with pharmaceutical compositions containing the same and methods of using such compounds for the treatment of cancer.
US20170271912 DISPATCHABLE PHOTOVOLTAIC PANEL WITH FULLY INTEGRATED ENERGY STORAGE AND GRID INTERACTIVE POWER CONVERSION  
A dispatchable photovoltaic (PV) panel product that includes multiple types of voltage sources is described. The product can include a PV panel that includes PV cells, a battery, and a panel level...
US20170271139 MASS SPECTROMETRY SYSTEMS WITH CONVECTIVE FLOW OF BUFFER GAS FOR ENHANCED SIGNALS AND RELATED METHODS  
Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for...
US20170266317 Synthetically Functionalized Living Cells for Targeted Drug Delivery  
Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining...
US20170266188 Methods For the Treatment of Cancer  
The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating...
9765291 Array of micromolded structures for sorting adherent cells  
An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and...
US20170263432 MINIATURE CHARGED PARTICLE TRAP WITH ELONGATED TRAPPING REGION FOR MASS SPECTROMETRY  
A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an...
9757431 Methods and compositions for the induction of hypothermia  
Provided herein are methods for the induction of hypothermia and the treatment of clinical insults in a subject through the administration of a regulated hypothermic multidrug combination. The...
9755273 Ion conducting fluoropolymer carbonates for alkali metal ion batteries  
Liquid or solid electrolyte compositions are described that comprise a homogeneous solvent system and an alkali metal salt dissolved in said solvent system. The solvent system may comprise a...
9752983 Optical density monitor and comparator systems and methods  
The present disclosure relates generally to systems and methods for determining the absorption coefficient and the optical density of a fluid as they relate to the wavelength of incident...
9750836 Systems and methods for performing the bacterial disinfection of a fluid using point radiation source  
A system for disinfecting a fluid, including: a flow cell including one or more inlet ports and one or more outlet ports, wherein the flow cell is configured to communicate a fluid containing a...
9750770 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
US20170250624 MULTI-LEVEL INVERTER  
Various examples are directed to systems and methods for a multi-level inverter to convert direct current (DC) to alternating current (AC). The inverter may comprise first, second and third...
9748735 Light-effect transistor (LET)  
Example photoconductive devices and example methods for using photoconductive devices are described. An example method may include providing a photoconductive device having a...
9748604 Ion conducting polymers and polymer blends for alkali metal ion batteries  
Electrolyte compositions for batteries such as lithium ion and lithium air batteries are described. In some embodiments the compositions are liquid compositions comprising (a) a homogeneous...
9744172 Pyrazolopyrimidine compounds for the treatment of cancer  
Compound of Formula I: are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof in the treatment of cancer.
US20170244976 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR COMPRESSING VIDEO IMAGES  
Methods, systems, and computer readable media for compressing video images are disclosed. According to one exemplary method, the method includes classifying image pixels in each video image of a...
US20170243522 RADIATION-FREE SIMULATOR SYSTEMS AND METHODS FOR SIMULATING FLUOROSCOPIC OR OTHER PROCEDURES  
Radiation-free simulator systems and methods for simulating fluoroscopic procedures or other medical procedures are provided. Simulator systems, methods and computer readable media are provided,...
US20170242033 EPITHELIAL CELL SPHEROIDS AND METHODS OF MAKING AND USING THE SAME  
Provided are epithelial cell spheroids including spheroids that have apical membranes and cilia that face towards the interior core of the spheroid and spheroids that have apical membranes and...
US20170239659 MICROFLUIDIC DEVICES AND APPLICATIONS THEREOF  
In one aspect, single-sided microfluidic devices are described herein. In some embodiments, a single-sided microfluidic device comprises a substrate, a photoconductive layer positioned over the...
US20170238852 EXTENDED ANALYTICAL PERFORMANCE OF CONTINUOUS GLUCOSE MONITORING DEVICES VIA NITRIC OXIDE  
The present invention relates to instruments and methods related to the in vivo analytical performance of percutaneously implanted nitric oxide (NO)-releasing amperometric glucose biosensors....
US20170233827 METHODS AND COMPOSITIONS FOR PROGNOSTIC AND/OR DIAGNOSTIC SUBTYPING OF PANCREATIC CANCER  
Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are provided. In some embodiments, the methods include determining...
US20170233797 Microfluidic Devices, Solid Supports for Reagents and Related Methods  
A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid...
US20170233739 DNA Aptamers Against Cancer and Uses Thereof in Delivery of Therapy and Diagnosis of Cancer  
Disclosed herein are unique single stranded DNA oligonucleotide products identified as binding with high affinity and specificity to ovarian tumor cells that may be used in the delivery of therapy...
US20170226180 Peptide Inhibitors of Sodium Channels  
The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates...
9728387 Solid phase extraction with capillary electrophoresis  
Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer....
9726874 Methods and systems for super-resolution optical imaging using high-index of refraction microspheres and microcylinders  
The present invention provides super-resolution optical imaging methods and systems, including: providing a sample to be optically imaged; providing a plurality of microstructures disposed...
9724305 Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells  
A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm...
US20170219498 OPTICAL GEOMETRY CALIBRATION DEVICES, SYSTEMS, AND RELATED METHODS FOR THREE DIMENSIONAL X-RAY IMAGING  
Optical geometry calibration devices, systems, and related methods for x-ray imaging are disclosed. An optical-based geometry calibration device is configured to interface with a two-dimensional...
9721089 Methods, systems, and computer readable media for efficient computer forensic analysis and data access control  
According to one aspect, the subject matter described herein includes a method for efficient computer forensic analysis and data access control. The method includes steps occurring from within a...
9718835 20(S)-sulfonylamidine derivatives of camptothecin and the use thereof as a potent antitumor agent  
The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor...
9717752 Uses of antagonists of hyaluronan signaling  
Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present...
US20170213039 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PREVENTING CODE REUSE ATTACKS  
Methods, systems, and computer readable media for preventing code reuse attacks are disclosed. According to one method, the method includes executing, on a processor, code in a memory page related...
9715953 Wideband negative-permittivity and negative-permeability metamaterials utilizing non-foster elements  
A metamaterial simultaneously exhibiting a relative effective permeability and a relative effective permittivity below unity over a wide bandwidth, including: one of a two-dimensional and a...
9714427 Methods and compositions for unsilencing imprinted genes  
The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of...
9713652 Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same  
Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a...
US20170204186 DEPLETION OF PLASMACYTOID DENDRITIC CELLS  
The present invention relates to antibodies targeted to BDCA2 that deplete plasmacytoid dendritic cells (pDC) and methods of using the antibodies to treat disorders associated with pDC.
US20170202847 METHODS FOR THE TREATMENT OF TUMORS  
The present invention is directed to methods of treating a tumor, in particular human tumors, including administering an effective amount of a MER tyrosine kinase inhibitor (MER TKI) to inhibit...
US20170202448 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PREDICTING EARLY ONSET GLAUCOMA  
Methods, systems, and computer readable media for predicting early onset glaucoma via structural parameters obtained via time and spectral-domain optical coherence tomography (SD-OCT) are...
9711341 Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods  
Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for...
9711126 Methods, systems, and computer readable media for simulating sound propagation in large scenes using equivalent sources  
The subject matter described herein includes an approach for wave-based sound propagation suitable for large, open spaces spanning hundreds of meters, with a small memory footprint. The scene is...