Patents and Patent Applications from University of North Carolina


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US20180204664 High Power Density Printed Circuit Board (PCB) Embedded Inductors  
Devices, systems, and methods of manufacture relating to PCB embedded inductors are described in the present disclosure. Namely, an example device includes a substrate having an upper surface and...
US20180201785 Solvent-Free Supersoft and Superelastic Materials  
The invention generally relates to compositions comprising polymer bottle brush and comb networks and methods of making polymer networks. Specifically, the disclosed polymer networks are prepared...
US20180200720 FLUIDIC DEVICES WITH FREEZE-THAW VALVES WITH ICE-NUCLEATING AGENTS AND RELATED METHODS OF OPERATION AND ANALYSIS  
Embodiments of the invention provide fluidic devices such as, but not limited to, microfluidic chips, with one or more freeze thaw valves (FTVs) employing one or more ice-nucleating agents (INAs),...
10026221 Wetland modeling and prediction  
Embodiments of the present application are directed to an automation process method to generate a set of wetland predictive variables using Light Detection and Ranging (“LiDAR”) data within a...
US20180196243 METHODS AND SYSTEMS FOR SUPER-RESOLUTION OPTICAL IMAGING USING HIGH-INDEX OF REFRACTION MICROSPHERES AND MICROCYLINDERS  
The present invention provides super-resolution optical imaging methods and systems, including: providing a sample to be optically imaged; providing a plurality of microstructures disposed...
US20180192641 Compositions and Methods for Preservation of Materials in the Amorphous State  
The present disclosure provides methods and compositions including a sugar and a choline hydrogen phosphate salt for preservation and stabilization of materials in the amorphous state. The...
10017785 Polypurine tract modified retroviral vectors  
An integration-defective retroviral vector transfer cassette lacking a functional polypurine tract (PPT) is provided. Also provided are isolated nucleic acids that include a heterologous...
10017441 Direct anti-markovnikov addition of acids to alkenes  
A method of making an anti-Markovnikov addition product, comprises reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said...
US20180187257 BIOMOLECULAR PROCESSING PLATFORM AND USES THEREOF  
The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure...
10013896 Modular staged reality simulator  
This invention is directed to a modular staged simulator and a process of simulating medical trauma and maladies for the purpose of training or certifying individuals including medical...
US20180177160 METHODS AND COMPOSITIONS FOR INDUCING HYGIENIC BEHAVIOR IN HONEY BEES  
The presently disclosed subject matter provides tritriacontene compositions for inducing hygienic behavior in honey bees; mite-infested brood extract compositions for inducing hygienic behavior in...
10007109 Wavelength discriminating imaging systems and methods  
The present disclosure provides wavelength discriminating imaging systems and methods that spatially separate (over different depths) the wavelength constituents of an image using a dispersive...
10005720 Compounds useful for the treatment of metabolic disorders and synthesis of the same  
The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators....
10004755 Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity  
Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK−/− tumors and...
10004410 System and methods for measuring physiological parameters  
The present invention relates generally to a system and methods for measuring physiological parameters. More specifically, the present invention relates to a noncontact technology by which one or...
US20180175836 METHOD AND APPARATUS FOR GENERATING HIGH CURRENT, FAST RISE TIME STEP-FUNCTIONS  
Method and apparatus to produce a step function with a designed transition (rise and/or fall) time on the order of <10 ns that reaches steady state by implementing a system that sums a number of...
US20180162956 WATER SOLUBLE NITRIC OXIDE-RELEASING POLYGLUCOSAMINES AND USES THEREOF  
The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical...
9997920 System and method for islanding detection and prevention in distributed generation  
Various examples are directed to systems and methods for detecting an islanding condition at an inverter configured to couple a distributed generation system to an electrical grid network. A...
9994805 Dissolution guided wetting of structured surfaces  
A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The...
US20180158662 PRESSURE DRIVEN FLUIDIC INJECTION FOR CHEMICAL SEPARATIONS BY ELECTROPHORESIS  
A pneumatic method, and associated apparatus, for injecting a discrete sample plug into the separation channel of an electrophoresis microchip (100) is disclosed. In a first step, pressurized gas...
US20180154495 FIBER BASED FINISHING TOOLS  
A finishing tool for modifying a surface of a part, including: a base, wherein the base is one or more of rotated and translated; and one or more fibers coupled to the base; wherein a base portion...
US20180153854 NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES  
This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and...
9992217 Methods, systems, and computer readable media for detecting malicious network traffic  
Methods, systems, and computer readable media for detecting malicious network traffic are disclosed. According to one method, the method includes caching network traffic transmitted between a...
9989532 Methods and compositions for detecting coagulation inhibitors  
The present invention provides a method of identifying a coagulation inhibitor in a sample, comprising: a) contacting a first portion of the sample with a substrate and thrombin; b) contacting a...
9989515 Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems  
Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length,...
US20180148497 BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM  
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods...
US20180148414 PHOTOREDOX-CATALYZED DIRECT C-H FUNCTIONALIZATION OF ARENES  
The invention generally relates to methods of making substituted arenes via direct C—H amination. More specifically, methods of making para- and ortho-substituted arenes via direct C—H amination...
US20180147314 SYSTEMS AND METHODS FOR PERFORMING THE BACTERIAL DISINFECTION OF A FLUID USING POINT RADIATION SOURCES  
A system for disinfecting a fluid, including: a flow cell including one or more inlet ports and one or more outlet ports, wherein the flow cell is configured to communicate a fluid containing a...
9984245 Methods, systems, and computer readable media for providing a secure virtual research space  
Methods, systems, and computer readable media for providing a secure virtual research space are disclosed. According to one aspect, a system for providing a secure virtual research space includes:...
9983412 Wide field of view augmented reality see through head mountable display with distance accommodation  
A head mountable augmented reality see through near eye display system includes a see through augmented reality image focal distance modulator for changing a distance at which augmented reality...
9982290 Methods and systems for using encapsulated microbubbles to process biological samples  
Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological...
US20180140722 METHODS AND COMPOSITIONS FOR TREATMENT OF HEART FAILURE  
The present invention relates to methods and compositions for treating heart failure in a subject using histone deacetylase (HDAC) inhibitors and/or histone acetyltransferases (HAT) activators.
US20180140249 FEEDBACK BRAIN STIMULATION TO ENHANCE SLEEP SPINDLES, MODULATE MEMORY AND COGNITIVE FUNCTION, AND TREAT PSYCHIATRIC AND NEUROLOGICAL SYMPTOMS  
The present invention relates to methods for modulating bursts of oscillatory brain activity, such as sleep spindles, in a subject. The invention further relates to methods of improving memory or...
9977644 Methods, systems, and computer readable media for conducting interactive sound propagation and rendering for a plurality of sound sources in a virtual environment scene  
Methods, systems, and computer readable media for conducting interactive sound propagation and rending for a plurality of sound sources in a virtual environment scene are disclosed. According to...
9976953 Optical density monitor and comparator systems and methods  
The present disclosure relates generally to systems and methods for determining the absorption coefficient and the optical density of a fluid as they relate to the wavelength of incident...
9975923 Methods and compositions for norovirus blockade epitopes  
The present invention provides methods and compositions comprising a chimeric norovirus capsid protein comprising a norovirus VP1 major capsid protein backbone comprising a norovirus epitope...
US20180138341 EFFICIENCY ENHANCEMENT OF SOLAR CELLS USING LIGHT MANAGEMENT  
A photovoltaic cell includes a junction, formed from an n-type semiconductor material and a p-type semiconductor material, a trench, opening toward the light-incident side of the junction, for...
US20180134802 COMPOSITIONS COMPRISING CHIMERIC ANTIGEN RECEPTORS, T CELLS COMPRISING THE SAME, AND METHODS OF USING THE SAME  
Provided are isolated nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens. Also provided are isolated polypeptides and CARs encoded by the isolated...
9973473 Methods, systems, and computer readable media for rapid filtering of opaque data traffic  
Methods, systems, and computer readable media for rapid filtering of opaque data traffic are disclosed. According to one method, the method includes receiving a packet containing a payload. The...
9970898 Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis  
Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic...
9969681 DTPA prodrugs, compositions thereof, and methods of using the same  
The present invention relates to trisodium diethylenetriamine pentaacetic acid (DTPA) prodrugs, such as, for example, DTPA di-ethyl esters. The invention further relates to compositions comprising...
US20180130650 INTEGRATED SAMPLE PROCESSING FOR ELECTROSPRAY IONIZATION DEVICES  
Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication...
US20180128591 NOISE REDUCTION TECHNIQUES, FRACTIONAL BI-SPECTRUM AND FRACTIONAL CROSS-CORRELATION, AND APPLICATIONS  
A measurement method and system include illuminating an object to be measured with light at two different wavelengths and an incident angle; capturing an image of the object; detecting a frequency...
US20180126379 FLUIDIC DEVICES WITH NANOSCALE MANIFOLDS FOR MOLECULAR TRANSPORT, RELATED SYSTEMS AND METHODS OF ANALYSIS  
Fluidic devices with a primary transport nanochannel(s) intersected by at least one nanoscale manifold for active control of capture, manipulation and transport of analyte molecules. The at least...
US20180125964 CHIMERIC DENGUE VIRUS E GLYCOPROTEINS COMPRISING MUTANT DOMAIN I AND DOMAIN II HINGE REGIONS  
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid...
9964663 Extended infrared imaging system  
An apparatus having: one or more infrared imagers capable of detecting light having wavelengths of 8-10 microns and 20-22 microns and a window transparent to light having wavelengths of 8-10...
9963666 Array of micromolded structures for sorting adherent cells  
An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and...
US20180119170 POLYPURINE TRACT MODIFIED RETROVIRAL VECTORS  
An integration-defective retroviral vector transfer cassette lacking a functional polypurine tract (PPT) is provided. Also provided are isolated nucleic acids that include a heterologous...
US20180116959 METHODS FOR FABRICATING ISOLATED MICRO- OR NANO-STRUCTURES USING SOFT OR IMPRINT LITHOGRAPHY  
The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint...
US20180110862 ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF  
Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials...