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US20120128647 |
DELIVERY OF COMPOUNDS WITH REHYDRATED BLOOD CELLS
Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are...
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US20120122810 |
Fused Pentacyclic Polyethers
Disclosed are polycyclic polyether compounds of formula I and pharmaceutical compositions comprising such compounds. wherein R, OR1, and R2 are as defined herein. Also disclosed are methods of...
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US20120114554 |
Engineered Aerosol Particles, And Associated Methods
An engineered aerosol particle for use in aerosol applications is provided. The engineered aerosol particle comprises a fabricated nanoparticle body member being non-spherical. The fabricated...
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8173596 |
Prouroguanylin, and synthetic analogs or proteolytic cleavage products derived from it, as therapeutic and diagnostic agents for diseases involving salt and/or fluid homeostasis
A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof. A method for determining the presence of or the progression of a disorder characterized...
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8165460 |
Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods for using
An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at...
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8163151 |
Assays for detection of Von Willebrand factor (vWF) multimers and for degradation of vWF by agents such as Adamts13 and related methods
Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are...
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US20120094318 |
E-CADHERIN AS A BIOMARKER OF GASTROESOPHAGEAL REFLUX DISEASE
The present invention provides methods of diagnosing and identifying subjects as having GERD comprising detecting E-cadherin fragments in a biological sample from the subject. The invention further...
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US20120091369 |
FOCUSING MULTIMODAL OPTICAL MICROPROBE DEVICES
The present invention provides an optical microprobe device and method for focusing multimodal radiation with wavelength-scale spatial resolution and delivering the focused radiation to a specimen,...
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8159219 |
MEMS 2D and 3D magnetic field sensors and associated manufacturing method
The disclosure provides Hall effect device configurations capable of measuring magnetic fields in two dimensions (2D) and three dimensions (3D) along with associated microelectromechanical system...
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8158728 |
Methods and materials for fabricating microfluidic devices
Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials...
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8158347 |
Determination of molecular age by detection of INK4a/ARF expression
The presently disclosed subject matter provides methods for determining the molecular age of a tissue. Also provided are methods for employing a molecular age that has been determined for a tissue...
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8156829 |
Methods of acoustic measurement and control of pharmaceutical sprays
Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected...
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8155262 |
Methods, systems, and computer program products for multiplexing computed tomography
Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object...
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8153589 |
JNK3 as a target for the treatment of angiogenesis-related diseases
Provided herein are methods for treating a subject having or at risk for an angiogenesis-related disorder. The methods include administering to the subject a therapeutically effective amount of an...
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8152305 |
Methods, systems, and computer program products for full spectrum projection
A broadband electromagnetic wave beam is projected from a broadband wave source (301). The wave beam is separated by an element (306) into narrowband wavelength beams. The narrowband beams are...
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8150111 |
Methods, systems, and computer program products for processing three-dimensional image data to render an image from a viewpoint within or beyond an occluding region of the image data
Methods, systems, and computer program products for processing three-dimensional image data to render an image from a viewpoint within or beyond an occluding region of the image data are disclosed....
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8148511 |
Methods and compositions for the detection and quantification of E. coli and Enterococcus
The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in...
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8145585 |
Automated methods and systems for the detection and identification of money service business transactions
The present disclosure provides an automated method for the detection and identification of money service business transactions, including: performing a preprocessing operation, wherein the...
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8138200 |
Compositions and methods for double-targeting virus infections and targeting cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus...
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8137914 |
Variants of alpha-fetoprotein coding and expression sequences
The invention discloses the sequences of variant forms of alpha-fetoprotein transcripts that have been identified in human hemopoietic progenitors but not in differentiated mature cells. The...
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US20120064128 |
NANO-METALLIC ALLOY DELIVERY SYSTEM FOR TREATMENT OF INFECTED CELLS AND LEGIONS
A system for delivering nano-metallic alloys to infected cells in a patient is disclosed. The nano-metallic alloy may be formed from binary, triple, or quadruple elemental compositions complexed in...
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US20120064075 |
CHIMERIC FACTOR VII MOLECULES WITH ENHANCED HALF LIFE AND METHODS OF USE
The present invention relates to novel proteins and methods of using chimeric Factor VIIa polypeptides.
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US20120050528 |
DIMENSIONAL MEASUREMENT THROUGH A COMBINATION OF PHOTOGRAMMETRY AND OPTICAL SCATTERING
A system for determining the position and location of a module comprising: a module which includes an optical generator which generates an optical beam; a diffractive element placed in the path of...
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8124393 |
Compositions and methods for inducing or inhibiting activities of selected human cells
Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to...
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US20120046394 |
HEMP FIBER REINFORCED COMPOSITE WITH RECYCLED HIGH DENSITY POLYETHYLENE AND PRODUCTION THEREOF
Novel structural materials composed of industrial hemp fiber with recycled high density polyethylene (HDPE) as well as methods for the production of the same are disclosed. The material's...
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8119589 |
Modulation of CD4+ T cell responses by a tick saliva protein, Salp15 and polypeptides derived therefrom
Salp15, biologically functional equivalents and fragments thereof, and nucleic acid molecules encoding the same are disclosed. Recombinant host cells, recombinant nucleic acids and recombinant...
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8119392 |
Biocompatible resists
This invention relates to biomaterials, biocompatible photoresists, and electroactive photoresists, and methods to engineer the interactions between biomaterials and cells. In one aspect, this...
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US20120039896 |
METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1
A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or...
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US20120034169 |
NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
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US20120031451 |
HIGH TEMPERATURE THERMOELECTRIC GENERATOR
The present invention relates to a high temperature thermoelectric generator. The generator includes at least one thermocouple thermally connected to a high temperature surface, a power management...
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US20120028353 |
HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class...
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US20120027278 |
METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAPPING REGIONS IN A MODEL OF AN OBJECT COMPRISING AN ANATOMICAL STRUCTURE FROM ONE IMAGE DATA SET TO IMAGES USED IN A DIAGNOSTIC OR THERAPEUTIC INTERVENTION
Methods, systems, and computer readable media for mapping a model of an object comprising an anatomical structure in a planning image and an intervention target region within it to...
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8106032 |
Lipid analogs for combating tumors
The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an...
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US20120021055 |
NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
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8101636 |
Linear dicationic terphenyls and their aza analogues as antiparasitic agents
Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds. The presently disclosed...
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8101191 |
Mycobacterial SecA2 mutants
Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that...
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8097410 |
Methods and compositions for vitamin K epoxide reductase
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide...
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US20120009268 |
Modified Virus Vectors and Methods of Making and Using the Same
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors...
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8090164 |
Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning
Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning are disclosed. A method for analyzing blood vessel attributes...
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US20110315219 |
EFFICIENCY ENHANCEMENT OF SOLAR CELLS USING LIGHT MANAGEMENT
A photovoltaic cell includes a junction, formed from an n-type semiconductor material and a p-type semiconductor material, a trench, opening toward the light-incident side of the junction, for...
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US20110313718 |
Construction Modulus Testing Apparatus and Method
A system and method of determining lift deflection during construction of aggregate columns allows for real time monitoring of construction to ensure meeting defined parameters. The amount of...
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US20110306878 |
INTERVENTIONAL DRUG DELIVERY SYSTEM AND ASSOCIATED METHODS
A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site...
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US20110301583 |
NON-INVASIVE LASER VASECTOMY
The present invention presents novel methods for performing noninvasive vasectomies in animals, including humans, and vasectomy clamps for use in such procedures. The invention further presents an...
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US20110301228 |
GENE THERAPY VECTOR FOR TREATMENT OF STEROID GLAUCOMA
The presently disclosed subject matter provides an inducible vector comprising a therapeutic gene. In some embodiments a method is provided for treating steroid glaucoma. In some embodiments a...
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8071559 |
Compositions and methods for cancer diagnosis and treatment
The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The...
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8067375 |
Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor
Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway.
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US20110284805 |
PRODUCTION OF MECHANICALLY EXFOLIATED GRAPHENE AND NANOPARTICLE COMPOSITES COMPRISING SAME
A method for producing nanospacer-graphene composite materials (i.e., mechanically-exfolitated graphene), wherein the graphene sheets are interspersed with nanospacers, thereby maintaining the 2D...
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8065089 |
Methods and systems for analysis of dynamic biological pathways
Disclosed is a hierarchical computational method to predict the expression value of genes in time-series microarray data. The method may include the step of first applying a nonlinear independent...
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US20110274666 |
METHOD OF ENGRAFTING CELLS FROM SOLID TISSUES
A method of repairing diseased or dysfunctional organs or of establishing a model system of a disease state is provided. For repairing diseased organs, the method involves engraftment of cells from...
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8048644 |
Biological indicator for monitoring the transport of micro-organisms in the environment
A method of using a biological indicator to detect and identify sources of fecal contamination such as leaking sewer lines, septic tanks, and holding lagoons, using a microorganism having a...
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