Patents and Patent Applications from University of Nebraska


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10026167 Method of obtaining micrographs of transparent or semi-transparent specimens using anisotropic contrast  
Anisotropic contrast methodology in combination with use of sample investigating polarized electromagnetic radiation to provide Jones or Mueller Matrix imaging data corresponding to areas on samples.
10023652 Method of targeting glycoproteins to treat cancer  
The present disclosure relates to a method of inhibiting tumor growth. More specifically, the present disclosure relates to the use of monoclonal antibodies for targeting truncated O-glycans on...
10022325 Compositions and methods for the treatment of cancer  
The present invention provides compositions and methods for the treatment of cancer are provided.
US20180194725 PYRROLOMYCINS AND METHODS OF USING THE SAME  
Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
10020010 Near-field heat transfer enabled nanothermomechanical memory and logic devices  
A thermomechanical memory/logic device is disclosed. In embodiments, the thermomechanical device includes a first thermally controlled terminal (e.g., hot terminal); a second thermally controlled...
US20180187215 DNA EDITING USING SINGLE-STRANDED DNA  
Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally...
10008966 Drive systems including sliding mode observers and methods of controlling the same  
At least one example embodiment discloses a method of estimating a position of a rotor in a motor. The method includes determining a first estimated position of the rotor using a first algorithm,...
US20180161115 Methods, Systems, and Devices Relating to Force Control Surgical Systems  
The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain...
9995628 Fiber-optic temperature and flow sensor system and methods  
A fiber optic sensor, a process for utilizing a fiber optic sensor, and a process for fabricating a fiber optic sensor are described, where a double-side-polished silicon pillar is attached to an...
9994844 Parental RNAi suppression of chromatin remodeling genes to control coleopteran pests  
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding...
US20180153844 CREATINE ESTER ANTI-INFLAMMATORY COMPOUNDS AND FORMULATIONS  
The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically...
US20180153631 Multifunctional Operational Component for Robotic Devices  
The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular...
US20180153390 PORTABLE LAPAROSCOPE SYSTEM  
A portable laparoscope is disclosed. In implementations, the portable laparoscope includes a housing and an elongated tube coupled to the housing. A lighting source and a camera are disposed...
US20180140659 ANALOGS OF C5a AND METHODS OF USING SAME  
Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective...
US20180140544 METHODS FOR ADMINISTRATION AND METHODS FOR TREATING CARDIOVASCULAR DISEASES WITH RESINIFERATOXIN  
There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient...
US20180140377 Gross Positioning Device and Related Systems and Methods  
Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a...
9976266 System including adjustable continuity joints and/or rotation mitigation sliding posts for rail elements  
A structural assembly may include a first prefabricated structural element having a first angled face at an end of the first prefabricated structural element; a second prefabricated structural...
9974866 Protein-poly(2-oxazoline) conjugates for enhanced cellular delivery and transport across biological barriers  
The present invention provides polymer-polypeptide conjugates comprising a poly(2-oxazoline) amphiphilic block copolymer linked to a polypeptide and methods of use thereof.
9970059 Survival predictor for diffuse large B cell lymphoma  
The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
US20180130511 MAGNETOELECTRIC MEMORY CELLS WITH DOMAIN-WALL-MEDIATED SWITCHING  
A magnetoelectric memory cell with domain-wall-mediated switching is implemented using a split gate architecture. The split gate architecture allows a domain wall to be trapped within a...
US20180128981 SPATIAL MODE FILTERING DEVICES AND METHODS TO MITIGATE MODAL DISPERSION AND INCREASE DATA RATE IN A STEP-INDEX OPTICAL FIBER LINK  
An optical fiber (OF) spatial mode filter element includes a structure having an internal cylindrical volume and is adapted to connect an exit end of a first OF with an entrance end of a second...
US20180127787 DNA EDITING USING SINGLE-STRANDED DNA  
Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally...
US20180127734 Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells  
An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to...
US20180125398 System and Method for Monitoring Pleural Fluid  
The disclosure is directed to intrapleural air leak detection and monitoring. According to various embodiments of the disclosure, an air leak may be detected utilizing at least one sensor to...
9962352 Creatine oral supplementation using creatine hydrochloride salt  
The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the...
9956166 Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin  
There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient...
9956043 Methods, systems, and devices for surgical access and procedures  
The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include...
US20180114614 Rare Earth-Free Permanent Magnetic Material  
The invention provides rare earth-free permanent magnetic materials and methods of making them. The materials can be used to produce magnetic structures for use in a wide variety of commercial...
US20180111017 ASSISTIVE REHABILITATION ELLIPTICAL SYSTEM  
An elliptical system is disclosed having a crank assembly configured to be adjusted in length to accommodate users having varying gaits. In some embodiments, the crank assembly includes a crank...
9951444 Method of fabricating a continuous nanofiber  
A method of fabricating a continuous nanofiber is described. The method includes preparing a solution of one or more polymers and one or more solvents and electrospinning the solution by...
US20180092988 NANOCARRIERS HAVING SURFACE CONJUGATED PEPTIDES AND USES THEREOF FOR SUSTAINED LOCAL RELEASE OF DRUGS  
Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by...
US20180071036 Robotic Devices with On Board Control & Related Systems & Devices  
The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include...
US20180066018 CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67  
Conformationally-stable peptide analogs of the response selective C5a agonist EP67 having the formula Tyr-Ser-Phe-Lys-Asp-Met-Xaa-(Xaa2)-(D-Ala)-Arg (SEQ ID NO:1), wherein Xaa is a modified...
US20180064565 AUTOMATED RETRIEVABLE HEMORRHAGE CONTROL SYSTEM  
Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The...
US20180056527 Quick-Release End Effector Tool Interface  
The various embodiments herein relate to a coupling apparatus for a medical device having a coupler body, a cavity defined in the coupler body, a rotatable drive component disposed within the...
US20180055584 Robotic Device with Compact Joint Design and an Additional Degree of Freedom and Related Systems and Methods  
The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations and at least three degrees of freedom. Other embodiments relate to...
US20180051061 Anti-Microbial Peptides and Coatings  
Antimicrobial peptides and methods of use are provided.
9895411 Analogs of C5a and methods of using same  
Materials and methods for treating and preventing an infection or disease, and for directly killing microorganisms, using carboxy-terminal C5a analogs, are provided.
US20180044643 NON-NEUROINVASIVE VIRUSES AND USES THEREOF  
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
US20180042630 Fluid Jet Arterial Surgical Device  
A catheter mounted arterial surgical tool has a body with a fluid jet prong extending from a distal end of the body along a prong axis that is parallel to and laterally offset from a body axis. A...
9888966 Methods, systems, and devices relating to force control surgical systems  
The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain...
9888870 System and method for monitoring pleural fluid  
The disclosure is directed to intrapleural air leak detection and monitoring. According to various embodiments of the disclosure, an air leak may be detected utilizing at least one sensor to...
9883911 Multifunctional operational component for robotic devices  
The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular...
US20180028457 Compositions and Methods for the Delivery of Therapeutics  
The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
US20180011106 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS  
Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate...
US20180008340 Methods, Systems, and Devices Relating to Surgical End Effectors  
The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically...
US20170369873 PARENTAL RNAI SUPPRESSION OF CHROMATIN REMODELING GENES TO CONTROL COLEOPTERAN PESTS  
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding...
9851294 Integrated mid-infrared, far infrared and terahertz optical Hall effect (OHE) instrument, and method of use  
System Stage, and Optical Hall Effect (OHE) system method for evaluating such as free charge carrier effective mass, concentration, mobility and free charge carrier type in a sample utilizing a...
9850313 Cancer biomarkers and methods of use thereof  
Methods and compositions for treating cancer, particularly breast cancer, are disclosed.
US20170354471 Methods, Systems, and Devices Relating to Robotic Surgical Devices, End Effectors, and Controllers  
The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection...