Patents and Patent Applications from University of Missouri


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US20180177920 GLASS DERIVED NANOPARTICLES FOR NERVE TISSUE REPAIR  
A biocompatible, biodegradable composite material, and method of using nanoparticles formed within the composite material for nerve repair are disclosed. The nanoparticles may not be formed until...
US20180177897 NOVEL RHODOL FLUOROPHORES FOR NEAR-INFRARED IMAGING  
The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research...
US20180171197 HEAT EXCHANGING THERMAL LIQUID CONTAINER  
A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material...
US20180168561 INSTRUMENT TO CLOSE FASCIA DURING LAPAROSCOPIC SURGERY  
A surgical instrument can be introduced to the abdominal cavity through a current trocar puncture to place a suture in the deep facia and peritoneum of the anterior abdominal wall. The instrument...
US20180161931 JOINING METALLURGICALLY INCOMPATIBLE METALS  
A method for joining a second alloy material to a first alloy material where the two alloy materials are incompatible, comprising forming three successive interface layers over a substrate...
9994516 Flexible to rigid nanoporous polyurethane-acrylate (PUAC) type materials for structural and thermal insulation applications  
Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also...
US20180152799 LOG COMPLEX COLOR FOR VISUAL PATTERN RECOGNITION OF TOTAL SOUND  
The present disclosure is generally directed to audio visualization methods for visual pattern recognition of sound. In particular, the present disclosure is directed to plotting amplitude...
US20180148724 SMN2 Element 1 Antisense Compositions and Methods and Uses Thereof  
The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide...
9984781 Solid-state nuclear energy conversion system  
A solid-state nuclear energy conversion system includes a crystalline insulator bombarded with radiation to create electron-hole pairs. A voltage source provides a potential bias across the...
9982020 Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses  
The present invention relates to polyamide compounds and their use in pharmaceutical compositions and in medical applications for the treatment of human papillomavirus infections and/or...
US20180145685 POWER GATING CIRCUIT UTILIZING DOUBLE-GATE FULLY DEPLETED SILICON-ON-INSULATOR TRANSISTOR  
Combining the functionality of sleep transistors with logic devices in power-gating circuits by utilizing fully depleted silicon-on-insulator (FDSOI) transistors. In an embodiment, a back gate of...
9976011 Polymer composites and fabrications thereof  
The present invention provides polymer composites reinforced with high aspect ratio reinforcing fillers selected from calcium phosphate nanofibers, nanoplates, submicron fibers, submicron plates,...
US20180134563 SALT-ASSISTED ULTRASONIC DISAGGREGATION OF NANODIAMOND  
Methods for disaggregating nanodiamond clusters, for example, by using ultrasound to break apart nanodiamond aggregates in a sodium chloride aqueous slurry. Compositions, such as aqueous...
US20180133342 NANOPARTICLE IMMUNOCONJUGATES  
Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as...
9958561 Apparatus and method for the determination of one or more neutron source characteristics  
A neutron detection apparatus includes a neutron detector and an analyzer. The neutron detector includes a plurality of neutron detector assemblies, where each of the neutron detector assemblies...
9956277 Bacillus based delivery system and methods of use  
Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of...
US20180100947 SPECTRAL ANALYSIS OF SURFACE WAVES TO DETECT SUBSURFACE VOIDS  
Systems and methods for detecting a subsurface cavity. A source applies a force to ground under inspection and a plurality of sensors coupled to the ground detect resulting surface waves. A...
US20180100806 FIBER-OPTIC MICRO-PROBES FOR MEASURING ACIDITY LEVEL, TEMPERATURE, AND ANTIGENS  
A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for...
US20180100208 GRAIN REFINEMENT IN IRON-BASED MATERIALS  
A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the...
US20180094240 ARTIFICIAL OOCYTE ACTIVATION  
The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the...
US20180094007 EPOXY PHOSPHONATE ESTER AS A COUPLING AGENT FOR TRANSITION METAL AND METAL OXIDE SURFACES  
A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring, wherein the epoxy group remains intact...
US20180093000 MULTIMODAL SILICA-BASED NANOPARTICLES  
The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle...
US20180088087 PHOTOACOUSTIC FLOW CELL FOR IDENTIFICATION OF RARE ANALYTES IN SUSPENSION  
A photoacoustic flow cell, the components of which may be made well in advance of conducting photoacoustic analysis, comprising (a) a chamber structure that defines a chamber, a chamber inlet, and...
9929654 High voltage gain DC/DC power electronic converters  
A DC/DC power converter provides high voltage gain using integrated boost and voltage multiplier (VM) stages. The boost cell operates according to a switching sequence to alternately energize and...
US20180077933 Compositions and Methods for Synthetic Amphiphile-Induced Changes in Plant Root Morphology  
The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of...
9924586 Systems and methods to generate a self-confined high density air plasma  
This disclosure relates to methods and devices for generating electron dense air plasmas at atmospheric pressures. In particular, this disclosure relate to self-contained toroidal air plasmas....
9918943 Systems and methods for endotoxin removal from fluids  
Systems and methods are provided for the removal of endotoxins from fluids. The methods can include the use of polymeric nanoparticles for binding endotoxins present in a fluid. The polymeric...
9908874 Separation method for active pharmaceutical ingredients (apis) from excipients in pharmaceutical formulations  
The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical formulation before the API is fully...
9901617 Cell permeable inhibitors of the scaffold protein plenty of SH3 domains (POSH) or Sh3Rfl  
Here, we identify Plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multi-protein scaffold network for TCR-mediated JNK1 activation in CD8+ T-cells. Disruption of the POSH/JIP-1...
US20180050904 FABRICATION OF MULTILAYER NANOGRATING STRUCTURES  
Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence,...
9898016 Variable product agrochemicals application management  
Methods and products are provided for facilitating application of variable-product agrochemicals, such as fertilizer, to an application area, such as a field. The fertilizer or agrochemical may...
US20180047570 LOW TEMPERATURE NANOWIRE GROWTH ON ARBITRARY SUBSTRATES  
The present invention provides a method to manufacture nanowires. In various embodiments, a method is provided for producing an oxidized metal layer as a heterogeneous seed layer on arbitrary...
US20180044743 DROSOPHILA MODEL OF HUMAN CERVICAL CANCER  
Disclosed is a transgenic Drosophila model of human papillomavirus-mediated cancer. Also disclosed is a method for screening a candidate therapeutic for Human papillomavirus-induced cell...
US20180042928 METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION  
The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic...
9888909 Endoscopic-enabled tongue depressor and associated method of use  
The invention provides an endoscopic-enabled tongue depressor, as part of a mouth gag unit, with two-grooved design, where the first groove is for intubation, and the second groove accommodates...
9885040 SMN2 element 1 antisense compositions and methods and uses thereof  
The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide...
US20180029013 MULTIFUNCTIONAL CERIUM-BASED NANOMATERIALS AND METHODS FOR PRODUCING THE SAME  
Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and...
US20180027783 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS  
The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been...
9883576 Low-power, compact piezoelectric particle emission  
A low-power, compact piezoelectric particle emitter for emitting particles such as X-rays and neutrons. A piezoelectric transformer crystal receives an input voltage at an input end and generates...
9872647 Detection of early stage alzheimer's disease and mild cognitive impairment  
Systems and methods are described herein for determining that a patient has indications mild cognitive impairment (MCI) or early stage Alzheimer's disease (AD). Microperimetry is used to assess...
US20180019495 DISTRIBUTED ENERGY STORAGE SYSTEM  
An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout...
US20180017979 Variable Product Agrochemicals Application Management  
Methods and products are provided for facilitating application of variable-product agrochemicals, such as fertilizer, to an application area, such as a field. The fertilizer or agrochemical may...
US20180008551 METALLIC AND PROTEIN/POLYMER NANOPARTICLE CONSTRUCTS, MULTI-DRUG VEHICLE AND FABRICATION METHODS  
A multidimensional nanoconstruct includes a three-dimensional thiolated protein, gelatin or polymer nanoparticle and exposed metallic nanoparticles bonded to outer surfaces of the particle. In a...
9862697 pH-sensitive fluorescent sensors for biological amines  
The invention is directed to dual-analyte fluorescent chemosensors for the direct detection and visualization (imaging) of neurotransmitters released upon exocytosis. The inventive sensor exploits...
9861958 Multifunctional cerium-based nanomaterials and methods for producing the same  
Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and...
US20180002742 Encoded Nanopore Sensor for Multiplex Nucleic Acids Detection  
The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity...
US20170360997 INORGANIC BIODEGRADABLE SUBSTRATES FOR DEVICES AND SYSTEMS  
Disclosed are biodegradable glass substrates that are useful as functional elements of solid-state devices. In particular, biodegradable glass substrates having a rapidly degradable glass and a...
US20170349640 MICRODYSTROPHIN PEPTIDES AND METHODS FOR TREATING MUSCULAR DYSTROPHY USING THE SAME  
According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological...
US20170347652 Enhancement of Antibiotic Efficacy  
Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with...
9830422 In silico biological and pharmaceutical modeling  
Systems, methods and computer-readable media are described herein for determining a protein's most-likely structural alignment. A maximum likelihood algorithm is utilized that compares possible...