Patents and Patent Applications from University of Missouri


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US20190356315 CROSS-TALK COMPUTING FOUNDATION for DIGITAL LOGIC  
The presently disclosed invention astutely turns the potentially detrimental crosstalk effect in nanocircuitry into an advantage by engineering interference among single lines. In one embodiment,...
10472630 SMN2 element 1 antisense compositions and methods and uses thereof  
The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide...
US20190341836 Device for Generating Electrical Power From Low Frequency Oscillations  
An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to...
10469076 Power gating circuit utilizing double-gate fully depleted silicon-on-insulator transistor  
Combining the functionality of sleep transistors with logic devices in power-gating circuits by utilizing fully depleted silicon-on-insulator (FDSOI) transistors. In an embodiment, a back gate of...
10467400 Visual storytelling authentication  
Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among...
10465258 Grain refinement in iron-based materials  
A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the...
10463044 Molecules that inhibit efflux pumps in multi-drug resistant bacteria and uses thereof  
Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with...
10456198 Guided wave ablation and sensing  
Systems and methods for the controlled delivery of laser light to target tissue using an improved waveguide. A waveguide controls transmission of wave energy to a target based on direct contact...
10451479 Multichannel ultra-sensitive optical spectroscopic detection  
Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which...
US20190319861 METHOD AND SYSTEM FOR SECURE RESOURCE MANAGEMENT UTILIZING BLOCKCHAIN AND SMART CONTRACTS  
This disclosure relates to a resource management system of a computing network. The design of the resource management system is an edge-Internet of Things (IoT) framework based on blockchain and...
US20190313632 CRYOPRESERVATION MEDIUM AND METHOD TO PREVENT RECRYSTALLIZATION  
The present invention is directed to a medium for preserving cells at non-cryogenic freezing temperatures. The medium comprises a hydrophilic and nontoxic polymer or other macromolecule, an...
US20190313615 METHODS FOR PROTECTING PORCINE FETUSES FROM INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)  
Methods for protecting porcine fetuses from infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The methods comprise breeding a female porcine animal with a male porcine...
10447135 Device for generating electrical power from low frequency oscillations  
An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to...
10441588 Methods and compositions for treating bacterial infection  
The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic...
US20190308912 NOVEL HIGHLY POROUS CERAMIC AND METAL AEROGELS FROM XEROGEL POWDER PRECURSORS, AND METHODS FOR THEIR PRODUCTION AND USE  
The present invention discloses novel methods for producing highly porous ceramic and/or metal aerogel monolithic objects that are hard, sturdy, and resistant to high temperatures. These methods...
10434498 Multifunctional cerium-based nanomaterials and methods for producing the same  
Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and...
10434032 Instrument-assisted soft tissue mobilization tool  
A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue...
US20190302465 SYSTEMS AND METHODS FOR AIRY BEAM OPTICAL COHERENCE TOMOGRAPHY  
A system and method for performing Optical Coherence Tomography on a sample utilizes collimated, phase modulated beams of light in an interferometer. At least one of the beams of light utilized...
10426842 Targeted nanoparticle conjugate and method for co-delivery of siRNA and drug  
Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the...
US20190293584 Detection of Living Cells  
Disclosed herein are method of detecting the presence of living cells in a sample by detecting the death of those cells. Because cell death can occur more rapidly than cell growth, which is often...
US20190290594 MANGIFERIN ENCAPSULATED GOLD NANOPARTICLES, FABRICATION METHODS AND CANCER THERAPEUTIC METHODS  
A method for forming encapsulated gold nanoparticles mixes mangiferin into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the...
US20190290396 ATMOSPHERIC NON-THERMAL GAS PLASMA METHOD FOR DENTAL SURFACE TREATMENT  
The provision of dental restorations can be improved by generating a cold atmospheric plasma inside the mouth of the patient and then applying that cold atmospheric plasma onto a dental...
10421783 Prostate-specific membrane antigen (PSMA) targeting peptides  
Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered,...
US20190282712 INHIBITOR-FUNCTIONALIZED ULTRASMALL NANOPARTICLES AND METHODS THEREOF  
Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a...
10405526 Porcine reproductive and respiratory syndrome virus resistant animals  
The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been...
US20190272960 DOPANT-FREE INEXPENSIVE HOLE TRANSPORTING MATERIALS FOR HIGHLY EFFICIENT AND STABLE PEROVSKITE SOLAR CELLS  
Disclosed herein are novel hole transporting materials comprising polycyclic heteroaromatic hydrocarbon compounds that are easy to synthesize and inexpensive. The hole transporting materials of...
US20190271029 Nucleic Acid Sequence and Capture by Formation of an Abasic Site-Derived Cross-Link  
Disclosed herein is a method of covalently crosslinking DNA strands. In certain aspects, the method comprises incubating a hybridized, double-stranded DNA polynucleotide (dsDNA), comprising a...
US20190270522 AERIAL DELIVERY SYSTEM  
An aerial payload delivery system uses a cruciform parachute canopy that is connected to base by plurality of suspension lines including an adjustable control line. A control system includes an...
US20190269938 NEUTRON CAPTURE THERAPY FOR INFECTION CONTROL OF SURGICAL IMPLANTS  
The present invention provides an implant comprising an isotope capable of producing a dose of ionizing radiation upon exposure to a flux of low energy neutrons, and a method in which, after...
10403810 Magnetic diode in artificial magnetic honeycomb lattice  
A magnetic artificial honeycomb lattice comprising a multiplicity of connecting elements separated by hexagonal cylindrical pores, wherein: (a) the hexagonal cylindrical pores: (i) have widths...
US20190256886 RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD  
An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a...
US20190250159 High Sensitivity Impedance Sensor  
Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria...
10373723 Isotope energy conversion and spent nuclear fuel storage systems  
The invention provides methods, devices and systems for excimer fluorescence energy conversion from isotopes. Unprocessed spent nuclear fuel can be used as an isotope, and processed spent nuclear...
10367221 Distributed energy storage system  
An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout...
10364195 Braze for ceramic and ceramic matrix composite components  
In some examples, a technique may include positioning a first part comprising a ceramic or ceramic matrix composite and a second part comprising a ceramic or a CMC adjacent to each other to define...
US20190227003 MICROWAVE REFLECTOMETRY FOR PHYSICAL INSPECTIONS  
Utilizing microwave reflections to compare a reference device with counterfeit and/or aging devices under test. The reflection from the device under test varies based on certain properties, which...
US20190225632 CYCLIC GERMANIUM COMPOUNDS AND APPLICATIONS THEREOF  
The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of...
US20190224642 METHODS OF USE AND MANUFACTURE OF SILVER-DOPED, NANO-POROUS HYDROXYAPATITE  
A silver-doped, nano-porous hydroxyapatite material is provided that can be utilized to capture radioactive iodine, 129I. Methods of using the silver-doped, nano-porous hydroxyapatite material to...
US20190217387 CONFINING MATERIAL DURING ADDITIVE MANUFACTURING PROCESSES  
Confining material particles during laser irradiation of the particles at ambient atmospheric pressure for additive manufacturing. In an embodiment, an optically transparent press permits...
10351611 Microdystrophin peptides and methods for treating muscular dystrophy using the same  
According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological...
10350330 Method to produce inorganic nanomaterials and compositions thereof  
A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo...
US20190214520 OPTICALLY CONTROLLED POWER DEVICES  
An electro-optically triggered power switch is disclosed utilizing a wide bandgap, high purity III-nitride semiconductor material such as BN, AlN, GaN, InN and their compounds. The device is...
US20190211348 INCREASING PLANT OIL CONTENT BY IMPROVING ACTIVITY OF ACETYL-COA CARBOXYLASE  
The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the...
US20190210973 COMPOUNDS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS  
Provided are compounds having Formula (1), compositions thereof, and methods of modulating CFTR activity. Also provided are methods of treating a condition associated with decreased CFTR activity...
US20190201379 BIS-AMINO ACID BASED COMPOUND AND USE THEREOF  
Compositions comprising bis(tryptophan) derivatives are provided that act as antimicrobials. Also provided are methods for reversing antibiotic resistance in a bacterium, or recovering or...
10341795 Log complex color for visual pattern recognition of total sound  
The present disclosure is generally directed to audio visualization methods for visual pattern recognition of sound. In particular, the present disclosure is directed to plotting amplitude...
10336661 Hierarchical self-assembled energetic materials and formation methods  
An energetic nanocomposite includes fuel nanoparticles and oxidizer nanoparticles covalently bonded to negatively charged functionalized graphene sheets. A preferred example includes Al fuel...
10330673 Fluorescent chemical sensor for biological amines  
The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the...
10329576 Method to develop high oleic acid soybeans using conventional soybean breeding techniques  
The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of...
10329528 Method of forming microparticles for use in cell seeding  
The present invention is directed to methods for forming microparticles useful for cell seeding and for conjugating protein to the surface of the microparticles. The method comprises co-injecting...