Patents and Patent Applications from University of Missouri


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US20170349640 MICRODYSTROPHIN PEPTIDES AND METHODS FOR TREATING MUSCULAR DYSTROPHY USING THE SAME  
According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological...
US20170347652 Enhancement of Antibiotic Efficacy  
Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with...
9830422 In silico biological and pharmaceutical modeling  
Systems, methods and computer-readable media are described herein for determining a protein's most-likely structural alignment. A maximum likelihood algorithm is utilized that compares possible...
9827323 Conjugated polymeric material and uses thereof  
Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and...
US20170336346 Addressable Electrode Arrays in Multiple Fluidic Compartments and Uses Thereof  
Methods and apparati for performing measurements of electrical signals in a multi-compartmented fluidic array format where the signal to noise ratio is improved are disclosed.
US20170333412 METHOD FOR TREATING LYMPHEDEMA  
The disclosure relates to the field of lymphedema therapy, more specifically, to a new pharmacological strategy to rescue the failed lymph pump system that can supplement, enhance or replace...
9820475 Porcine reproductive and respiratory syndrome virus resistant animals  
The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically...
9814719 Methods and compositions for treating bacterial infection  
The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic...
US20170323692 Apparatus, Systems and Methods for Conversion of Scalar Particle Flow to an Electrical Output  
A scalar particle conversion apparatus, system and method are disclosed. The apparatus includes an anode and a crystalline cathode disposed within an electrolytic fluid or gas. A voltage source is...
9807987 Recombination activating gene 2 gene targeting vector, production of SCID-like miniature pigs by TALEN-mediated gene targeting and use thereof  
There are provided to a Rag-2 (Recombination activating gene 2) gene targeting vector, a method for producing SCID-like miniature pigs introduced with the vector, and a use thereof.
9805928 Low temperature nanowire growth on arbitrary substrates  
The present invention provides a method to manufacture nanowires. In various embodiments, a method is provided for producing an oxidized metal layer as a heterogeneous seed layer on arbitrary...
US20170309358 SOLID-STATE NUCLEAR ENERGY CONVERSION SYSTEM  
A solid-state nuclear energy conversion system includes a crystalline insulator bombarded with radiation to create electron-hole pairs. A voltage source provides a potential bias across the...
US20170300686 VISUAL STORYTELLING AUTHENTICATION  
Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among...
US20170297221 METHOD AND APPARATUS FOR FABRICATING CERAMIC AND METAL COMPONENTS VIA ADDITIVE MANUFACTURING WITH UNIFORM LAYERED RADIATION DRYING  
A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources...
US20170292109 METHOD OF FORMING MICROPARTICLES FOR USE IN CELL SEEDING  
The present invention is directed to methods for forming microparticles useful for cell seeding and for conjugating protein to the surface of the microparticles. The method comprises co-injecting...
9783779 Artificial oocyte activation  
The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the...
US20170281198 SYSTEM, APPARATUS, AND METHOD FOR GRAFTING TISSUE  
Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate...
9771577 Methods for analyzing lariat RNA  
The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of RNA is specifically treated to...
9770528 Biomaterial compositions  
Biomaterial compositions comprising organosilicon monomers (such as silorane monomers) and chemical curing systems or dual chemical/light curing systems, in conjunction with optional...
9766252 Peptide with gold binding and EGFR receptor affinity and same attached to gold nanostructure  
An embodiment of the invention is a peptide comprising four domains, wherein domain I consists of thioctyl or monocytl, domain II consists of 2 to 3 positively charged amino acids selected from...
US20170260326 METHOD FOR PREPARING LOADED NANOPARTICLES  
Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(ε-caprolactone), PGA is poly(glycolic acid), and PLA is...
US20170258495 MEDIUM SUPPLEMENT TO INCREASE THE EFFICIENCY OF OOCYTE MATURATION AND EMBRYO CULTURE IN VITRO  
The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive...
9752116 Self-assembling cell aggregates and methods of making engineered tissue using the same  
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises...
US20170247281 METHOD TO PRODUCE INORGANIC NANOMATERIALS AND COMPOSITIONS THEREOF  
A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo...
US20170246275 CANCER IMMUNE-BASED THERAPY  
The present disclosure provides a novel therapeutic vaccine approach that triggers a therapeutic antitumor response. The inventive approach is to selectively eliminate the carbohydrate sequences...
US20170240596 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETING PEPTIDES  
Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered,...
US20170237365 Thread Shaped Contact Electrification Fiber  
An electrostatic power generation fiber comprising a thread-shaped core that comprises a conductive component; a charge building-inducting-tunneling layer on the core that comprises a contact...
9733257 Biomarkers of osteoarthritis  
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test...
9732379 Encoded nanopore sensor for multiplex nucleic acids detection  
The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity...
9728660 Optically-triggered linear or avalanche solid state switch for high power applications  
The present invention relates to a solid state switch that may be used as in optically-triggered switch in a variety of applications. In particular, the switch may allow for the reduction of...
9716202 Optically activated linear switch for radar limiters or high power switching applications  
The present invention relates to a solid-state optically activated switch that may be used as limiting switch in a variety of applications or as a high voltage switch. In particular, the switch...
US20170202751 Dental Etchant Compositions Comprising One Or More Dentin Collagen Cross-Linking Agents, Methods Of Producing The Same, And Methods Of Use  
Dental etchant compositions, processes for making the same, and methods for using the dental etchant compositions are disclosed. The dental etchant compositions include at least one acid and one...
US20170197103 ECCENTRIC WEIGHTLIFTING MACHINE AND ASSOCIATED METHOD OF USE  
An eccentric weightlifting machine that includes a first pole connected to a first weight and to a device acted on by a user, a second pole connected to a second weight and to a motor, wherein the...
US20170191471 ELECTRICAL/CHEMICAL THRUSTER USING THE SAME MONOPROPELLANT AND METHOD  
A thruster operable in a chemical mode or in an electrospray mode using the same liquid monopropellant for operation in both modes is described having a multiplicity of a microthrusters made of a...
9696275 Addressable electrode arrays in multiple fluidic compartments and uses thereof  
Methods and apparati for performing measurements of electrical signals in a multi-compartmented fluidic array format where the signal to noise ratio is improved are disclosed.
9694032 Soy, lentil or extract stabilized, biocompatible gold nanoparticles  
The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The...
9689964 Electronic receiver device detection system and method  
A super regenerative receiver detection system and method that includes a computing system that stores and executes a cross modulation correlation component to modulate a radio-frequency (RF)...
9687477 Modulation of sphingosine 1-phosphate metabolizing enzymes for the treatment of negative-strand RNA virus infections  
The present invention relates to compounds and methods for the prevention or treatment of infections by negative strand RNA viruses, such as influenza virus and measles virus, wherein said...
US20170172585 SYSTEM, APPARATUS, AND METHOD FOR CREATION AND IMPLANTATION OF TISSUE GRAFTS  
Systems, apparatus, and methods for forming a non-circular tissue graft from donor tissue, and a corresponding recipient site in patient's tissue, are disclosed. In one embodiment, a cutting guide...
US20170168045 AU MULTICOMPONENT NANOMATERIALS AND SYNTHESIS METHODS  
A multicomponent nanomaterial AuNP(DTDTPA)(Ga), where DTDTPA is an amino-carboxylate ligand (diethylene triamine pentaacetic acid, DTPA) linked to the surface of the Au nanoparticle (NP) via...
9668754 System, apparatus, and method for grafting tissue  
Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate...
US20170152474 SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME  
Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to...
US20170145386 SELF-ASSEMBLING CELL AGGREGATES AND METHODS OF MAKING ENGINEERED TISSUE USING THE SAME  
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises...
US20170143240 ACTIVITY ANALYSIS, FALL DETECTION AND RISK ASSESSMENT SYSTEMS AND METHODS  
A method for determining the risk of a person falling is provided. The method includes acquiring depth image data that comprises a plurality of frames that depict a person walking through a home,...
US20170137376 FLEXIBLE TO RIGID NANOPOROUS POLYURETHANE-ACRYLATE (PUAC) TYPE MATERIALS FOR STRUCTURAL AND THERMAL INSULATION APPLICATIONS  
Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also...
9652691 Method of predicting crop yield loss due to N-deficiency  
A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of light by the crop canopy measured from remote sensor...
9652569 Nanostructured dielectric materials for high energy density multi layer ceramic capacitors  
A high energy density multilayer ceramic capacitor, having at least two electrode layers and at least one substantially dense polycrystalline dielectric layer positioned therebetween. The at...
US20170121354 EPOXY PHOSPHONATE ESTER AS A COUPLING AGENT FOR TRANSITION METAL AND METAL OXIDE SURFACES  
A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring, wherein the epoxy group remains intact...
9625590 Apparatus and method for determination of one or more free neutron characteristics  
A neutron detection system may include a neutron detector including a plurality of neutron detection devices, a plurality of discrete neutron moderating elements, wherein each of the neutron...
9624500 Metabolic engineering of plants for increased homogentisate and tocochromanol production  
The invention provides methods and compositions for modifying tocochromanol biosynthesis in plants. The present invention thus surprisingly and beneficially provides for increasing desired...