Patents and Patent Applications from University of Minnesota


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US20180267120 Multi-Banded RF-Pulse Enhanced Magnetization Imaging  
Embodiments can provide a method for multi-banded RF-pulse enhanced magnetization imaging, the method comprising determining, by a processor, a frequency offset against a central frequency by...
US20180264090 ADENO-ASSOCIATED VIRUS MEDIATED GENE TRANSFER TO THE CENTRAL NERVOUS SYSTEM  
A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a...
US20180264038 CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS FOR AUTO- AND ALLO-IMMUNITY  
Provided herein are methods and materials for treating autoimmune diseases and alloimmune diseases. Specifically, provided are a pharmaceutical composition comprising a therapeutically effective...
10077799 Crankshaft assembly  
A crankshaft assembly includes a crankshaft member, a crank pin shaft member and a clamp. The crankshaft member includes a first central axis and an end having a first circumferential mating...
10077340 Poly(beta-methyl-delta-valerolactone) block polymers  
Block copolymers include a poly β-methyl-δ-valerolactone (PMVL) block. The PMVL blocks can be formed from biosynthesized β-methyl-δ-valerolactone (MVL). The PMVL block may be formed from...
US20180258903 IN-BANK VERTICAL AXIS HYDROPOWER SYSTEM  
A hydropower system for generating electrical energy from water flowing along a bank includes a shaft configured to rotate about a vertical axis, an electrical generator configured to generate...
US20180258495 METHOD TO DETECT COLON CANCER BY MEANS OF THE MICROBIOME  
A method and kit to detect colon cancer in a human by detecting the presence or absence, or relative amount (abundance) of, certain bacteria in a sample, is provided.
US20180258396 NK CELLS EXHIBITING AN ADAPTIVE PHENOTYPE AND METHODS FOR PREPARING AND FOR USING  
This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and...
US20180258131 NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY  
The invention provides a compound of formula I: wherein R1-R6 and X have any of the values described herein, as well as pharmaceutical compositions comprising such compounds and therapeutic...
10073522 Articles of handwear for sensing forces applied to medical devices  
An article of handwear for grasping a medical device in a medical environment includes a base adapted to be worn by a hand of a wearer. A sensor assembly is carried by the base. The sensor...
10072356 Magnetic material including α″-Fe16(NxZ1-x)2 or a mixture of α″-Fe16Z2 and α″-Fe16N2, where Z includes at least one of C, B, or O  
A magnetic material may include α″-Fe16(NxZ1-x)2 or a mixture of α″-Fe16N2 and α″-Fe16Z2, where Z includes at least one of C, B, or O, and x is a number greater than zero and less than one. In...
10071248 Systems and methods for tuning closed-loop phasic burst stimulation based on a phase response curve  
Systems and methods are provided for determining optimized settings for a closed-loop stimulation system based on analyzing a phase response curve measured from electrophysiological activity, such...
US20180255426 INTEGRATED ASSISTIVE SYSTEM TO SUPPORT WAYFINDING AND SITUATION AWARENESS  
A method includes a mobile device receiving data from a first beacon in a plurality of beacons, wherein the data indicates a plurality signals strengths of signals received by the first beacon...
US20180254836 OPTICAL INTERCONNECT IN SPIN-BASED COMPUTATION AND COMMUNICATION SYSTEMS  
Techniques are described for data transfer in spin-based systems where digital bit values are represented by magnetization states of magnetoresistive devices rather than voltages or currents. For...
US20180251524 EpCAM TARGETED POLYPEPTIDES, CONJUGATES THEREOF, AND METHODS OF USE THEREOF  
Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain...
US20180250747 ADDITIVELY MANUFACTURED HEAT EXCHANGERS  
Heat exchangers are manufactured by three-dimensional (3D) printers by printing subsequent layers of a material in a print direction. The heat exchangers include one or more tubes. The one or more...
US20180250443 BIOMIMETIC HYBRID GEL COMPOSITIONS AND METHODS OF USE  
Disclosed herein are dry blends of polyanionic and polycationic macromolecules, solvating fluids serving as cell suspension fluids, hybrid gel compositions, and methods for treatment of patients...
US20180250058 MATERIALS AND TREATMENTS USING PIEZOELECTRIC EMBOLIC MATERIALS  
An embolic agent and a piezoelectric substance are mixed together. The mixture can be delivered to a tumor or other object by a non-invasive method. The embolic agent prevents movement of the...
RE47026 High field magnetic resonance  
A magnetic resonance system is disclosed. The system includes a transceiver having a multichannel receiver and a multichannel transmitter, where each channel of the transmitter is configured for...
10069430 Modular converter with multilevel submodules  
One aspect of the disclosure includes a submodule topology for a modular multilevel converter. The submodule topology includes two electronic switches connected together with a first series...
10068689 Iron nitride permanent magnet and technique for forming iron nitride permanent magnet  
A permanent magnet may include a Fe16N2 phase constitution. In some examples, the permanent magnet may be formed by a technique that includes straining an iron wire or sheet comprising at least...
10065976 Titanium (IV) compounds and methods of forming heterocyclic compounds using same  
The present disclosure provides Titanium (IV) compounds and methods of making heterocyclic compounds such as pyrroles using Titanium (IV) compounds. In certain embodiments, the Titanium (IV)...
US20180245090 HAPLOID INDUCER LINE FOR ACCELERATED GENOME EDITING  
Provided herein are materials and in planta methods for using haploid inducer lines containing a targeted endonuclease to generate transgenic or non-transgenic plants with targeted mutations...
US20180243423 FUNCTIONALIZED NANOPARTICLES AND METHODS OF USE THEREOF  
Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles functionalized with streptokinase. Certain...
US20180242655 SMART FABRIC  
Compressive garments described herein include an inner layer, a middle layer coupled to the inner layer, the middle layer comprising a plurality of circuits, each circuit of the plurality of...
10063255 Stochastic computation using deterministic bit streams  
In some examples, a device includes an integrated circuit comprising a computational unit configured to process at least two input bit streams that each include a sequential set of data bits or...
10061005 Apparatus and method for multi-band MR imaging  
A magnetic resonance method and system are provided for providing improved multi-band (MB) magnetic resonance imaging. The adaptive MB imaging can be achieved by providing one or more modified...
US20180238901 HIGH PRECISION SPECTRAL FRET ASSAYS  
Provided herein are methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. In one embodiment, the method includes providing a target protein,...
US20180237447 THERAPEUTIC COMPOUNDS  
and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for...
US20180236013 METHODS FOR MAKING AND USING ANTIMICROBIAL PEPTIDES  
Provided herein are genetically modified microbes. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide that includes a pheromone-responsive region. In one...
US20180235760 SYSTEMS AND METHODS FOR TREATING PRESERVED EJECTION FRACTION CONDITIONS  
A device of a shape memory material configured to implement a predetermined level of expansion while allowing contraction and twist can be implemented in a portion of a vascular system, such as in...
US20180230105 THERAPEUTIC COMPOUNDS  
The invention provides compounds of formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as...
US20180229654 SENSING APPLICATION USE WHILE DRIVING  
A method includes determining a gaze parameter for how a user gazes relative to a mobile device and based on the gaze parameter, determining whether the user is a driver of a vehicle or a...
10047100 Compounds from renewable resources  
Compounds of formula III: and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates useful for preparing compounds of formula III and...
US20180222953 SARCOMERE BIOSENSOR AND METHODS OF USE THEREOF  
Certain embodiments of the invention provide a polypeptide comprising: (a) an amino acid sequence encoding a first chromophore;(b) a first linker;(c) an amino acid sequence having at least about...
US20180221022 RETAINER ASSEMBLY  
A fastener includes a first end, an elongate body, and a second end. The first end includes a cylinder having an entry aperture at a terminus, a wall, and an inner lumen aligned with a...
10043129 Functional assessment of a network  
A computer-implemented method for performing a functional assessment of a network is disclosed. The network includes a plurality of interacting network elements. The method includes measuring a...
US20180217217 SYSTEM AND METHOD FOR DYNAMIC, CARDIAC PHASE-RESOLVED QUANTITATIVE LONGITUDINAL RELAXATION PARAMETER MAPPING  
Systems and methods for producing quantitative maps of a longitudinal relaxation parameter, such as a longitudinal relaxation time (“T1”), using magnetic resonance imaging (“MRI”) are described....
US20180215865 TELECHELIC PREPOLYMERS AND REACTION PRODUCTS THEREOF  
Gem-dialkyl cyclooctene monomers, telechelic prepolymers prepared by ring opening metathesis polymerization of the monomers, and polymers such as polyurethanes comprising the reaction product of...
US20180214483 THERAPEUTIC METHODS INVOLVING MODULATING INFLAMMASOME ACTIVATION OF MYELOID-DERIVED SUPPRESSOR CELLS  
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor...
10035719 System and membrane for wastewater-generated energy and gas  
Systems and methods for producing and extracting a gas from a wastewater fluid including multiple sheets or layers that form a composite membrane. The composite membrane includes a sandwich...
10034934 Porcine epidemic diarrhea virus vaccines and methods of use thereof  
The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and methods of use thereof.
10034871 Salts and compositions useful for treating disease  
The invention provides a combination or salt of lipoic acid and a compound of formula (I): The combinations and salts are useful for treating diabetes.
US20180206981 CALCIFIED ANNULUS MODEL FOR TRANSCATHETER AORTIC VALVE REPLACEMENT  
A device includes an annular, elastic band having a rectangular cross section. A foil band is affixed to a surface of the elastic band. A contiguous fabric sheath is configured to encase the...
10032613 Non-parametric methods for mass spectromic relative quantification and analyte differential abundance detection  
A method of normalizing data can comprise globally normalizing at least a first and second data distribution by normalizing the proximal compositional proportionality of the abundance of the...
10030089 Sugar free, statistical copolymers made from at least three monomers  
Disclosed herein are polymers made from at least three monomers of formulae (I), (II), (III), and (IV) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon...
10028980 Compositions and methods for transplantation of colon microbiota  
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a...
US20180204131 STOCHASTIC COMPUTATION USING PULSE-WIDTH MODULATED SIGNALS  
Devices and techniques are described in which stochastic computation is performed on analog periodic pulse signals instead of random, stochastic digital bit streams. Exploiting pulse width...
US20180203083 SYSTEM AND METHOD FOR SIMULTANEOUS RADIO FREQUENCY TRANSMISSION AND RECEPTION IN MAGNETIC RESONANCE IMAGING  
Systems and methods for simultaneous radio frequency (“RF”) transmission and reception for nuclear magnetic resonance applications, such as magnetic resonance imaging (“MRI”) are described. The...
US20180203077 SPIN HALL EFFECT MAGNETIC STRUCTURES  
An article may include a substantially perpendicularly magnetized free layer having a first magnetic orientation in the absence of an applied magnetic field. The article may also include a spin...