Patents and Patent Applications from University of Minnesota


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US20180044655 HYPOCHLORITE RESISTANT CYANURIC ACID HYDROLASES AND METHODS OF USE THEREOF  
The present invention relates to engineered cyanuric acid hydrolase enzymes that are resistant to hypochlorite and compositions and devices comprising such enzymes. The present invention also...
US20180044641 PRODUCTION OF INSULIN PRODUCING CELLS  
The invention provides methods for differentiating stem cells along the pancreatic lineage as well as large scale culture methods. The present invention further provides pancreatic progenitor...
9890221 Cellulose ethers esterified with dicarboxylic acid  
Esterified cellulose ethers comprising groups of formula —C(O)—CHR′—CHR″—COOA, wherein, R′ and R″ are hydrogen or (—S)m(—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2...
9888673 Genetically modified cells, tissues, and organs for treating disease  
Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.
US20180039600 INTEGRATED REMOTE SENSING TOOLS FOR TIMELY PREDICTIONS OF CROP QUALITY AND YIELD  
A method includes receiving outside temperatures for a plurality of days and calculating growing degree units based on the received temperatures. Intensities for a plurality of wavelengths of...
US20180037620 ETV2 AND USES THEREOF  
Described herein is a method for producing a chimeric non-human animal expressing a human ETV2 gene comprising: a) generating an ETV2 null non-human animal cell, wherein both copies of the...
US20180036321 TRIPTOLIDE PRODRUGS  
The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of...
9885621 Stitched stretch sensor  
A stitched sensor including a plurality of threads stitched to a textile in a stitch geometry is described. The plurality of threads includes a conductive thread, and the stitch geometry is...
9884866 Immunomodulators and immunomodulator conjugates  
The invention provides compounds of formula I: wherein R1-R3, Ra, and Rb have any of the values defined herein, and salts thereof. The compounds have immunomodulatory properties.
US20180030023 RECOVERY OF MONOMER FROM POLYURETHANE MATERIALS BY DEPOLYMERIZATION  
Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the polymer and release the monomer. The...
US20180028574 Compositions and Methods for Transplantation of Colon Microbiota  
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a...
US20180028573 Compositions and Methods for Transplantation of Colon Microbiota  
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a...
US20180028535 3-HYDROXYPYRIMIDINE-2,4-DIONE-5-CARBOXAMIDES AS POTENT INHIBITORS OF HIV  
Various embodiments described herein are directed to compounds of formula (I), (II), (III) or (IV) for use as potent inhibitors of HIV integrase and for treatment of patients afflicted with AIDS....
9880243 Sideband processing for magnetic resonance  
A method includes applying a pulse train to a spin system in a scanner. The pulse train has a plurality of discontinuities in a time domain. The method includes receiving a response from the spin...
9878045 Triorthogonal reagents for dual protein conjugation  
The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot...
9878002 Compositions and methods involving endogenous retrovirus proteins  
This disclosure describes methods and compositions that involve endogenous retrovirus proteins as diagnostic markers and/or therapeutic agents. The detection of endogenous retrovirus envelope...
US20180025889 NONTHERMAL PLASMA SYNTHESIS  
An apparatus may include a nonthermal plasma reactor vessel, a gaseous core precursor inlet, a gaseous shell precursor inlet, and a plasma source. The reactor vessel may include a core formation...
US20180025841 APPLIED MAGNETIC FIELD SYNTHESIS AND PROCESSING OF IRON NITRIDE MAGNETIC MATERIALS  
Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an...
US20180024087 Electrochemical sensors with a chemically attached molecular redox buffer  
Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor...
US20180023953 EXTENDED KALMAN FILTER FOR 3D LOCALIZATION AND VISION-AIDED INERTIAL NAVIGATION  
Localization and navigation systems and techniques are described. An electronic device comprises a processor configured to apply an extended Kalman filter (EKF) as the electronic device traverses...
US20180023940 POSITION SENSING SYSTEM WITH AN ELECTROMAGNET  
A position sensing system for measuring a position of a moving object includes an electromagnet configured to generate an alternating magnetic field, and a magnetic sensor configured to measure an...
9874539 Ion-selective electrodes and reference electrodes with a solid contact having mesoporous carbon  
The present description discloses solid-contact (SC) electrodes that use mesoporous carbon such as colloid-imprinted mesoporous (CIM) carbon as the interlayer. The electrodes can be ion-selective...
9874203 Devices having a volume-displacing ferrofluid piston  
A device for use in compressing or expanding a working fluid, such as a gas, includes a container, a piston, working fluid, ferrofluid, and at least one magnetic component. The piston includes a...
9867758 Device and method for gait synchronized sensory stimulation of the lower extremities  
A device can comprise: a trigger chamber, having a trigger elastic wall and a trigger base wall, the trigger chamber configured for relative motion between the trigger elastic wall and the trigger...
US20180008704 CD200 INHIBITORS AND METHODS OF USE THEREOF  
The present invention provides in certain embodiments conjugates comprising at least one CD200 inhibitor and an adjuvant, and methods of reversing or modulating immune suppression in a patient...
9865096 Material analysis of anatomical items  
A computer-implemented method for medical device modeling includes accessing an electronic definition for a model of a three-dimensional item and an electronic definition of a three-dimensional...
9864218 Spin magneto-optical modulator  
Techniques are described for a device that includes an optical channel configured to transport an optical signal. The device further includes a magnetic material with low optical absorption...
9863985 State estimation of electrical power networks using semidefinite relaxation  
A semidefinite (SDR) programming formulation for state estimation (SE) of nonlinear AC power systems is described. The techniques make use of convex semidefinite relaxation of the original problem...
9862928 Generation of natural killer cells and lymphoid tissue inducer-like (LTi-like) NK-22 cells  
The present invention relates generally to methods to prepare NK and LTi-like, NK22 cells from HSCs and uses of those cells.
9861464 Cardio-embolic stroke prevention  
An embolic protection device comprises an intravascular flow-interactive surface supported by an expandable, substantially cylindrical frame, wherein the frame is configured to expand and engage...
US20180002438 CHIMERIC ANTIGEN RECEPTORS, COMPOSITIONS, AND METHODS  
This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric...
US20180001952 COLLISION DETECTION  
Bicycle collision systems, apparatus, and methods may include, or use, one or more various sensing apparatus to detect vehicles or other objects that may collide, or potentially collide, with a...
US20180001385 IRON NITRIDE POWDER WITH ANISOTROPIC SHAPE  
Techniques are disclosed for milling an iron-containing raw material in the presence of a nitrogen source to generate anisotropically shaped particles that include iron nitride and have an aspect...
US20180000872 COMPOSITIONS AND METHODS FOR C. DIFFICILE TREATMENT  
The present disclosure provides compositions and methods for treating Clostridium difficile infection (CDI) including primary and recurrent CDI. In particular, the compositions and methods...
9858816 Determining parking space occupancy using a 3D representation  
Systems and methods for determining park stall occupancy are disclosed herein. The systems and methods include receiving a three dimensional representation of a parking stall in a parking lot. The...
9858665 Medical imaging device rendering predictive prostate cancer visualizations using quantitative multiparametric MRI models  
A user-independent, quantitative, multiparametric MRI model is developed and validated on co-registered correlative histopathology, yielding improved performance for cancer detection over single...
US20170367933 HYDROPHOBIC DENTAL SURFACES  
An example article may include a dental surface, a hydrophobic coating on the dental surface, and a restorative layer on the hydrophobic coating. An example technique may include applying, on a...
US20170367820 PULMONARY-SYSTEMIC SHUNT DEVICES AND RELATED METHODS  
A method for treating a patient may include establishing an anastomosis between a pulmonary artery and an aorta; and pumping blood from the pulmonary artery to the aorta when the pulmonary artery...
9852637 Vehicle-to-vehicle congestion monitoring using ad hoc control  
A vehicle-to-vehicle communication unit includes a vehicle communication transceiver that transmits and receives messages to and from other vehicles. The messages include at least one safety...
9851316 System and method for determining a spatial thermal property profile of a sample  
A sensing system uses three-omega sensing to determine a spatial profile of thermal property within a sample. The sensing system electrically powers a lossy electrical conductor at different...
9850497 Gene targeting methods and tools  
Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to...
9849171 PRRSV compositions  
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus...
9848934 Thermochemical ablation of bodily tissue  
Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.
US20170366940 TRAVEL AND ACTIVITY CAPTURING  
A mobile device includes a positioning module sampling at least a position of the mobile device at a sampling rate when active and a processor capable of determining whether a mobile device is...
US20170365381 PRESERVATION OF STRAIN IN IRON NITRIDE MAGNET  
A permanent magnet may include a Fe16N2 phase in a strained state. In some examples, strain may be preserved within the permanent magnet by a technique that includes etching an iron...
US20170360907 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING GRAFT VERSUS HOST DISEASE  
ILC2 cells play a role in the pathogenesis of graft versus host disease (GvHD) and idiopathic pneumonia syndrome (IPS), both conditions associated with allogeneic stem cell transplantation....
9847471 Method and remotely adjustable reactive and resistive electrical elements  
Apparatus and method that includes providing a variable-parameter electrical component in a high-field environment and based on an electrical signal, automatically moving a movable portion of the...
US20170359082 STOCHASTIC COMPUTATION USING DETERMINISTIC BIT STREAMS  
In some examples, a device includes an integrated circuit comprising a computational unit configured to process at least two input bit streams that each include a sequential set of data bits or...
9841480 Localization of magnetic particles by means of swift-MRI  
Positive contrast localization of magnetic (e.g. superparamagnetic) particles in vivo or in vitro by means of SWIFT-MRI using the imaginary component of MR image data in combination with an...
9840634 High-resolution patterning of graphene by screen and gravure printing for highly flexible printed electronics  
Graphene ink compositions as can be utilized with gravure and screen printing processes, to provide flexible electronic components with high-resolution printed graphene circuitry.