Patents and Patent Applications from University of Michigan


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US20180200517 COCHLEAR IMPLANT  
A device for implantation into a scalia tympani of a cochlea is disclosed. The device comprises blocks and compliant elements interconnecting the blocks with one of the compliant elements disposed...
10024301 Textile composite wind turbine blade  
A wind turbine blade includes at least one mandrel and a sock that covers the at least one mandrel. The sock includes a plurality of braided fibers within a matrix material. The fibers can be made...
10023564 G protein-coupled receptor kinase 2 inhibitors and methods for use of the same  
Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular,...
US20180195203 DEVICES AND METHODS FOR ELECTROCHEMICAL LIQUID PHASE EPITAXY  
Electrochemical liquid phase epitaxy (ec-LPE) processes and devices are provided that can form precipitated epitaxial crystalline films or layers on a substrate. The precipitated films may...
US20180193030 TOURNIQUET  
A portable compact tourniquet includes a pivot housing, a strap carriage that is linearly translatable relative to the pivot housing, and a screw assembly. When the screw assembly is operated, the...
10020595 Negative group delay circuit  
A circuit for generating a negative group delay (NGD). The circuit comprises one or more electrical components, at least one of which has an input impedance that is sufficient for the electrical...
US20180190927 EXCITED STATE MANAGEMENT  
Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the...
US20180187196 INHIBITORS OF DEK PROTEIN AND RELATED METHODS  
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or...
US20180186779 G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME  
Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular,...
US20180185550 Microporous Hydrogel Scaffolds for Cell Transplantation  
The present disclosure relates generally to biomaterial implants and methods for delivering a cell to an individual in need thereof and, more particularly, to biomaterial implants and techniques...
10014485 Stacked white OLED having separate red, green and blue sub-elements  
The present invention relates to efficient organic light emitting devices (OLEDs). More specifically, the present invention relates to white-emitting OLEDs, or WOLEDs. The devices of the present...
10010263 Technology for robust regional and global liver function quantification from clinical multi-phase MRI  
A robust liver function quantification algorithm to quantify regional and global liver function using temporally sparse-sampled multi-phase MRI with gadoxetic-acid injection is provided. The liver...
US20180183040 ELECTROCHEMICAL DEVICE INCLUDING THREE-DIMENSIONAL ELECTRODE SUBSTRATE  
An electrode includes a porous metallic substrate and a conductive electrode material disposed on the porous metallic substrate. The conductive electrode material includes an active material...
US20180177638 MAGNETOELASTIC IMPLANTABLE ACTUATION DEVICE AND METHOD  
An implantable actuation device that may be used with a glaucoma drainage device or attached to an ocular surface, a method of making an implantable actuation device, and a method of preventing...
US20180177417 IMPLANTABLE MICRO-COMPONENT ELECTRODES  
The present disclosure provides a method of fabricating an implantable micro-component electrode. The method includes disposing an electrically non-conductive material directly onto a surface of...
10006823 Microdischarge-based transducer  
The distance between microscale electrodes can be determined from microdischarge current and/or capacitance distribution among a plurality of electrodes. A microdischarge-based pressure sensor...
10006023 Phage microarray profiling of the humoral response to disease  
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods and...
US20180174699 STRETCHABLE COMPOSITE CONDUCTORS FOR FLEXIBLE ELECTRONICS, STRETCHABLE PLASMONIC DEVICES, OPTICAL FILTERS, AND IMPLANTABLE DEVICES AND METHODS FOR MANUFACTURE THEREOF  
New stretchable electrically conductive composite materials comprising at least one polymer and a plurality of nanoparticles are provided, which exhibit high conductivity even at high strain...
US20180169962 FASTENER AND METHOD FOR JOINING DISSIMILAR MATERIALS  
A fastener and method for joining dissimilar materials. The fastener has a metal body and a hollow portion. The method includes the steps of: layering a thermoplastic first component with a second...
US20180169234 Method of Treating Alvelor Bone Loss Through The Use of Anti-Sclerostin Antibodies  
The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.
10002657 Enhanced memory device  
Various implementations described herein are directed to an integrated circuit. The integrated circuit may include a memory cell configured to operate in multiple retention states including a...
10000134 Wireless charging system for charging vehicular battery  
A wireless charging system may be used to charge a battery in a vehicle via a receiving coil. The wireless charging system may include a coil charge device, a linear track, a linear motor, and a...
9999412 Fistula management device and method  
A fistula management device for preventing enteric contents from leaking out of a bowel via a fistula opening in the bowel. The device comprises a tubular body that defines a main fluidic...
US20180164261 MICROFLUIDIC PHOTOIONIZATION DETECTOR  
A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The...
US20180164197 METHOD FOR ISOLATING EXTRACELLULAR VESICLES USING AQUEOUS TWO-PHASE SYSTEM  
Disclosed is a method of isolating extracellular vesicles using an aqueous two-phase system (ATPS), including (a) preparing an ATPS by mixing a first material and a second material, which are...
US20180162934 COMPOSITIONS AND METHODS RELATING TO INHIBITING CANCER CELL GROWTH AND/OR PROLIFERATION  
The present invention determined that EGFL6 functions as a tumor vascular regulator of ovarian cancer stem cells (CSC). In addition, the present invention determined that a novel EGFL6 blocking...
US20180162906 CAHUITAMYCINS AND METHODS OF MAKING AND USING THE SAME  
Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided...
US20180160886 SPRAY CAP FOR CHROMOENDOSCOPY  
A spray cap for use with an endoscope. The endoscope includes a liquid channel and an open channel. The spray cap includes a body portion connectable with an endoscope having an end wall defining...
9997777 Electrochemical device electrode including cobalt oxyhydroxide  
This invention discloses an electrochemical device having a multilayer structure and methods for making such a device. Specifically, this invention discloses a multilayer electrochemical device...
9994885 Nonribosomal peptide synthetases  
The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention provides polynucleotide sequences useful...
US20180158367 MICROFLUIDIC ACTUATORS WITH INTEGRATED ADDRESSING  
A fluidic logic and actuator system for outputting a displacement having a fluidic logic circuitry layer including a fluidic control input and a plurality of fluidic latching memory units. At...
US20180155289 MIXED DISULFIDE CONJUGATES OF THIENOPYRIDINE COMPOUNDS AND USES THEREOF  
This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the...
US20180154779 HYBRID ENERGY STORAGE  
A system includes a first energy storage device, a second energy storage device coupled to the first energy storage device and charged via a charging current from the first energy storage device,...
US20180154186 HISTOTRIPSY THERAPY SYSTEMS AND METHODS FOR THE TREATMENT OF BRAIN TISSUE  
A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy...
9989969 Visual localization within LIDAR maps  
An apparatus and method for visual localization of a visual camera system outputting real-time visual camera data and a graphics processing unit receiving the real-time visual camera data. The...
9989001 Discrete time rate-based model predictive control method for internal combustion engine air path control  
A discrete time rate-based model predictive controller for air path control for a diesel engine regulates VGT position and EGR valve position to specified set points by coordinated control of...
9988322 Process for fluorinating compounds  
Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo,...
US20180149887 Enhancement of Forward Scattering, Suppression of Backscattering, and Spectral Tuning of Optical Hedgehog Particles  
Optical materials for optical devices are provided that comprise a plurality of hedgehog-shaped microparticles. Each hedgehog microparticle comprises a core region formed of a first material...
US20180148353 PLASMA WATER PURIFIER HAVING PACKED BED DISCHARGES WITH WATER DIELECTRIC BARRIERS  
A system for water purification having a water inlet being distributed into a plurality of streams defining extended dielectric barrier layers with high surface area to volume ratios and a plasma...
US20180146880 TECHNOLOGY FOR ROBUST REGIONAL AND GLOBAL LIVER FUNCTION QUANTIFICATION FROM CLINICAL MULTI-PHASE MRI  
A robust liver function quantification algorithm to quantify regional and global liver function using temporally sparse-sampled multi-phase MRI with gadoxetic-acid injection is provided. The liver...
9983110 Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes  
The disclosure provides a label-free viscosity-based analyte detection system using paramagnetic beads as an asynchronous magnetic bead rotation (AMBR) microviscometer. It is disclosed herein that...
9983097 Methods and apparatus for assessing tire health through monitoring effective tire rolling radius  
Methods and apparatus for assessing tire health through monitoring an effective tire rolling radius are disclosed. An example method includes obtaining velocity data for a vehicle from a global...
9981338 Hybrid friction stir welding for dissimilar materials through electro-plastic effect  
A hybrid Friction Stir Welding approach and device for dissimilar materials joining employing Electro-Plastic Effect. The approach and device include an introduction of high density, short period...
US20180143112 Multi-Mode Separation for Target Detection and Cell Growth Monitoring  
Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual...
US20180141003 ULTRAFILTRATION MEMBRANE, DEVICE, BIOARTIFICIAL ORGAN, AND RELATED METHODS  
The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and...
US20180140550 CLEAVABLE POLYMERIC MICELLES  
The present invention provides compositions, systems, and methods employing cleavable polymeric micelles. For example, provided herein are compositions comprising micelles that contain a...
9980197 Baseband processing circuitry for wake-up receiver  
A method of operating a baseband processing unit for a wake-up receiver. The method includes receiving a signal from a transmitting device that contains a pseudo-random code. The method further...
9979284 Self-oscillating switched-capacitor DC-DC converter  
A self-oscillating DC-DC converter structure is proposed in which an oscillator is completely internalized within the switched-capacitor network. This eliminates power overhead of clock generation...
9978968 Photovoltaic cells with a graded active region achieved using stamp transfer printing  
Disclosed herein are processes for fabricating organic photosensitive optoelectronic devices with a vertical compositionally graded organic active layer. The processes use either a single-stamp or...
9974844 Cancer vaccine compositions and methods of using the same  
The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the...