Patents and Patent Applications from University of Miami


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US20170233448 INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USE  
Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising...
US20170226218 Method for In Vivo Expansion of T Regulatory Cells  
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
US20170216240 METHODS FOR MODULATING IKS CHANNEL ACTIVITY  
Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate Iks channels to treat conditions associated with a disruption in Iks channel...
US20170202907 Materials and Methods of Treating Dyslipidemia  
Described herein are materials and methods for treating dyslipidemia in a mammalian subject in need thereof comprising administering a growth hormone-releasing hormone (GHRH) antagonist or variant...
US20170191058 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...
9683217 In vitro culture conditions for T-cell acute lymphoblastic leukemia/lymphoma  
We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially T-cell acute...
US20170165336 METHODS AND COMPOSITIONS FOR TRANSGENE EXPRESSION IN A HERPESVIRUS VECTOR SYSTEM  
Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous recombinant transgene of interest encoding an...
9672394 System and method for securing backscatter wireless communication  
A system and method for securing backscatter communication. In one embodiment, a backscatter communication system includes a reader. The reader is configured to receive backscatter transmissions....
US20170147743 RAPID IDENTIFICATION OF PHARMACOLOGICAL TARGETS AND ANTI-TARGETS FOR DRUG DISCOVERY AND REPURPOSING  
A computing system automatically analyzes various drug or other compound targets using biologic activity data for cellular proteins, and develops a target/anti-target matrix identifying...
US20170146526 COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS  
Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the...
US20170145110 ANTIBODY-ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
US20170107277 METHODS OF MODULATING INFLAMMASOME ACTIVITY TO TREAT INFLAMMATORY CONDITIONS  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
9611313 Antibody-endostatin fusion protein and its variants  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
9603925 Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20170082625 METHOD AND SYSTEM FOR MICROFILTER-BASED CAPTURE AND RELEASE OF CANCER ASSOCIATED CELLS  
A slotted microfilter is coated with a phase changeable material having a hydrophobic state under a first temperature and a hydrophilic state under a second temperature. An example coating...
US20170080027 EXPANDED UTILITY OF RED-CELL DERIVED MICROPARTICLES (RMP) FOR TREATMENT OF BLEEDING  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as...
US20170074849 A TEST STRIP FOR MELAMINE DETECTION  
Described here is a test strip for detection of melamine, comprising: a support configured for capillary flow of a fluid sample from a first end of the support to a second end of the support that...
US20170065233 Image Guided Small Animal Stereotactic Radiation Treatment System  
A dual, imaging and radiation system provides for finely aligned movement of a subject through the use of a computer controlled mounting stage having separate, non-gantry translational and...
US20170058259 CELL CULTURE MEDIA  
A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base;...
US20170037400 MODULATING IMMUNE RESPONSES  
Modulators of STING are able to upregulate or down regulate immune responses. Administration of such modulators can be used to treat diseases or other undesireable conditions in a subject either...
US20170003303 Innate Immune Proteins As Biomarkers for CNS Injury  
The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein...
9533013 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
9512209 Methods of modulating inflammasome activity to treat inflammatory conditions  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
US20160341728 BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
US20160339043 COMPOSITIONS AND METHODS FOR REDUCING INTRAOCULAR PRESSURE  
Compositions, kits, and methods for reducing intraocular pressure (IOP) in a subject (e.g., human) include at least one naturally occurring or synthesized version or analog thereof of a lipid...
9499627 Method for in vivo expansion of T regulatory cells  
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
9486645 Radiation therapy device for ocular melanoma  
The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through...
9486521 Therapeutic applications targeting SARM1  
The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM)...
US20160305942 METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS AND PROVIDING PROGNOSIS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.
9468677 Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20160271083 TREATMENT OF CARDIAC REMODELING AND OTHER HEART CONDITIONS  
The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some...
9447160 Compositions, methods and kits for treatment of cancer and autoimmune diseases  
The present invention is directed to fusion proteins having an IL-21 cytokine portion and an anti-CD20 antibody portion, and methods of using such fusion proteins. The invention also provides...
US20160263051 STABLE LIQUID FORMULATIONS OF VOLATILE GAS ANESTHETICS  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
US20160250303 PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION  
Methods and compositions are provided to modulate the activity of Perforin-2. Provided herein are various components of the Perforin-2 activation pathway. In specific embodiments, inhibitors of...
US20160243218 INHIBITION OF NONSENSE MEDIATED DECAY PATHWAYS  
Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions comprise one or more cell binding...
US20160235289 RETINAL NERVE FIBER LAYER VOLUME ANALYSIS FOR DETECTION AND PROGRESSION ANALYSIS OF GLAUCOMA  
Techniques are provided that detect the onset and/or progression of glaucoma from analyzing the area and or volume of suppression and inferior retinal nerve fiber layers.
9394526 FROG/TOAD conditionally silenced vectors for hypoxia gene therapy  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under...
9393271 GHRH agonists for islet cell transplantation and function and the treatment of diabetes  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve...
US20160187343 COMPOSITIONS AND METHODS FOR IDENTIFYING A RISK OF CANCER IN A SUBJECT  
Disclosed herein are compositions and methods for determining a risk of cancer, such as head and neck squamous cell carcinoma, in a subject using a bodily fluid sample from the subject and assays...
US20160184363 METHOD FOR ISOLATION AND PURIFICATION OF MICROVESICLES FROM CELL CULTURE SUPERNATANTS AND BIOLOGICAL FLUIDS  
The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles...
US20160166652 NOVEL N- AND C-TERMINAL SUBSTITUTED ANTAGONISTIC ANALOGS OF GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
9358231 Type II RAF kinase inhibitors  
The present invention relates to novel compounds which are able to modulate b-raf kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.
US20160146819 CLASSIFICATION SYSTEM, METHODS AND KIT FOR CLASSIFYING, PREDICTING AND TREATING BREAST CANCER  
A novel classification system for breast cancer based on normal breast cell phenotypes and various expression levels of estrogen receptor (ER), androgen receptor (AR), and vitamin D receptor...
US20160143939 COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF CARDIOVASCULAR,IMMUNOLOGICAL AND INFLAMMATORY DISEASES  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20160133843 PURIFICATION OF CARBON NANOTUBES VIA SELECTIVE HEATING  
The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein...
US20160102365 ASSAYS, METHODS AND KITS FOR ANALYZING SENSITIVITY AND RESISTANCE TO ANTI-CANCER DRUGS, PREDICTING A CANCER PATIENT'S PROGNOSIS, AND PERSONALIZED TREATMENT STRATEGIES  
Described herein are assays, methods and kits for analyzing sensitivity of a subject's cancerous tumor to a drug, predicting responses of cancerous tumors to drugs, determining the prognosis of a...
9308269 Stable liquid formulations of volatile gas anesthetics  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
9308083 Corneal implant and method of delivering a corneal implant  
A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in...
US20160058798 METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY ENDOSCOPIC-MEDIATED (OR LAPAROSCOPIC-MEDIATED) TRANSPLANTATION OF STEM CELLS INTO/ONTO BILE DUCT WALLS OF PARTICULAR REGIONS OF THE BILIARY TREE  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
US20160054299 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...