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Patents and Patent Applications from University of Miami


Matches 1 - 50 out of 432 1 2 3 4 5 6 7 8 9 >
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8697597 Self sustained electrochemical promotion catalysts  
A method and system for the reduction of pollutant NOx gases from automobile exhaust, as well as a method of reforming hydrocarbons, using a self-sustaining catalyst comprising an ion conductive...
8691942 N- and C- terminal substituted antagonistic analogs of GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
8685400 Modulating inflammasome activity and inflammation in the central nervous system  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
8685384 Recombinant cancer cell secreting modified heat shock protein-antigenic peptide complex  
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic...
US20140088177 RECOMBINANT VSV FOR THE TREATMENT OF TUMOR CELLS  
Vesicular Stomatitis Viruses expressing foreign nucleic acid sequences were highly attenuated but were lytic for abnormal cells, such as cancers, infected cells. Methods of treatment include the...
8679426 Microscope accessory and microplate apparatus for measuring phosphorescence and cellular oxygen consumption  
A microplate apparatus having a bottom plate defining a plurality of very small microwells (for example, each having a volume of 0.02 or less) for containing sample material and a top plate...
US20140079712 Therapeutic Applications Targeting SARM1  
The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM) ...
US20140074147 CLOT CAPTURE DEVICE  
A system and method for preventing the movement of emboli away from a vascular region. The system generally includes a medical device having a clot capture assembly, a shaft, and a sheath disposed...
US20140058068 Novel GH-RH analogs with potent agonistic effects  
There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their...
US20140057847 CARDIOPROTECTIVE EFFECTS OF GHRH AGONISTS  
Disclosed herein are methods demonstrating that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent...
US20140037682 HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY  
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients...
8641193 Spectral contrast for glaucoma imaging  
A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes...
US20140024042 BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
US20140023627 TOPICAL CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20140023621 BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR  
Methods for the isolation of CD271+ stem cell populations are important in the prevention or treatment of cardio-vascular diseases and repair of cardiac tissue. The methods are applicable to stem...
8609617 KLF family members regulate intrinsic axon regeneration ability  
This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like ...
8606346 Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital X-ray system during thermotherapy  
A method of thermally inducing and monitoring changes to localized regions of tissue by illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed...
US20130316011 Expanded Utility of Red Cell-Derived Microparticles (RMP) for Treatment of Bleeding  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as...
8586030 Co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20130302293 COMPOSITIONS, CELLS, KITS AND METHODS FOR AUTOLOGOUS STEM CELL THERAPY  
Described herein are compositions, kits and methods for stimulating angiogenic functions of stem cells and/or progenitor cells having pro-angiogenic potential (e.g., endothelial progenitor cells...
8562976 Co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
8551770 Enhanced oxygen cell culture platforms  
Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides...
US20130261058 ACCELERATION OF WOUND HEALING BY GROWTH HORMONE RELEASING HORMONE AND ITS AGONISTS  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
US20130261055 Novel N- and C- terminal substituted antagonistic analogs of GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 96) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
US20130243724 COMPOSITIONS AND METHODS FOR INDUCING MIGRATION BY DENDRITIC CELLS AND AN IMMUNE RESPONSE  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
US20130237442 Methods and Compositions for Diagnosis of Non-Viable Early Pregnancy  
Methods and compositions are provided for diagnosing an abnormal early pregnancy in a mammalian subject by contacting a biological sample of the subject with a reagent that enables measurement of...
US20130236437 COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF CARDIOVASCULAR, IMMUNOLOGICAL AND INFLAMMATORY DISEASES  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20130236433 METHODS, COMPOSITIONS, CELLS, AND KITS FOR TREATING ISCHEMIC INJURY  
The methods, compositions, cells and kits described herein are based on the discovery that stem cells, when injected into ischemic tissue of mammals, can be protected by preconditioning of the...
US20130226292 ISLET STORING INTRAOCULAR IMPLANT, METHOD OF USING THE SAME AND KIT INCLUDING THE SAME  
An intraocular implant that has an anterior portion, at least one haptic element designed to localize the intraocular implant within an eye, a posterior portion, and an islet storage feature...
US20130224237 INHIBITION OF NONSENSE MEDIATED DECAY PATHWAYS  
Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions comprise one or more cell binding ligands...
US20130224108 Methods for the Treatment of Head and Neck Squamous Cell Carcinoma  
This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease...
US20130212125 BIOINFORMATICS SEARCH TOOL SYSTEM FOR RETRIEVING AND SUMMARIZING GENOTYPIC AND PHENOTYPIC DATA FOR DIAGNOSING PATIENTS  
A computer system having a processor, non-transitory memory and a communication system is described. The communication system is coupled to a network and communicates with one or more genetic...
US20130209514 APTAMER-TARGETED COSTIMULATORY LIGAND APTAMER  
Compositions for inducing or enhancing immunogenicity of a tumor comprise bi- and multi-specific aptamers binding to a tumor cell and an immune cell. These compositions have broad applicability in...
8507433 Cardioprotective effects of GHRH agonists  
Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we...
US20130203622 TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS  
Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
US20130195807 AGONISTS OF GROWTH HORMONE RELEASING HORMONE AS EFFECTORS FOR SURVIVAL AND PROLIFERATION OF PANCREATIC ISLETS  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
US20130190190 MOLECULAR TARGETS FOR MODULATING INTRAOCCULAR PRESSURE AND DIFFERENTIATION OF STEROID RESPONSES VERSUS NON-RESPONDERS  
Molecular biomarkers as indicators of responses to steroids, drug targets, predictors of steroid responses and identification of drugs for modulating intraocular pressure. Kits and methods of...
US20130189237 CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20130184330 COMPOSITIONS AND METHODS FOR INDUCING CANCER CELL DEATH  
Described herein are pharmaceutical compositions including a sugar or mannose analog (e.g., 2-DG) and an inhibitor of at least one of PERK and GCN2 (e.g., an inhibitor of PERK and an inhibitor of...
8485476 Discrete co-flow jet (DCFJ) airfoil  
The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
8484263 Method for keyless protection of data using a local array of disks  
A method secures data in a network. The data includes a data message that has a first bit length. A random number is generated and transformed to create a first pseudo random number. The first...
8475785 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20130144212 DEVICE FOR RADIATION-ACTIVATED LOCALIZED DELIVERY OF TREATMENT AGENTS  
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the device...
8451584 Solid state energy storage device and method  
A solid state energy storage device has two electrodes, a membrane separator and a solid electrolyte having a substantially solid solvent, a salt and a mediator. The energy storage device stores...
US20130131152 HYPOXIA REGULATED CONDITIONALLY SILENCED AAV EXPRESSING ANGIOGENIC INDUCERS  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under hypoxic...
US20130089594 MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION  
The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can...
US20130052215 TUMOR VACCINE  
The invention relates to the fields of medicine, immunology, and oncology. More specifically, the invention relates to methods and compositions for inducing an immune response against a tumor in an...
US20130040324 PERIFUSION DEVICE  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
US20130039933 STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES  
Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
8357701 Galactokinase inhibitors  
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
Matches 1 - 50 out of 432 1 2 3 4 5 6 7 8 9 >