Patents and Patent Applications from University of Miami


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US20180156821 TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS  
Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
US20180155692 METHODS AND COMPOSITIONS FOR CONVERTING NON-ENDOCRINE PANCREATIC TISSUE INTO INSULIN-PRODUCING CELLS  
Compositions and methods are provided for generating islet-like cell clusters. The methods include culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective...
9980923 Stable liquid formulations of volatile gas anesthetics  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
9974646 Keratoprosthesis, and system and method of corneal repair using same  
A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support....
US20180104186 METHODS AND COMPOSITIONS FOR THE TREATMENT OF EPIDERMOLYSIS BULLOSA  
The present invention provides compositions and methods for treating epidermolysis bullosa.
9943223 Retinal nerve fiber layer volume analysis for detection and progression analysis of glaucoma  
Methods and systems of analyzing retinal nerve fiber layer for detecting glaucoma and/or other retinal nerve fiber indicated eye conditions include collecting retinal nerve fiber layer image data,...
US20180099032 VACCINE COMPOSITIONS AND METHODS OF USE THEREOF  
Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production,...
US20180086700 INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME  
Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can...
US20180085432 STING (Stimulator of Interferon Genes), A Regulator of Innate Immune Responses  
Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
US20180078611 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS, AND IMMUNOTOXINS  
This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25...
US20180050111 Dendrimer Conjugates for Coating Cells  
The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in...
US20180037947 KITS AND METHODS FOR PATHOGEN DETECTION  
Kits and methods for detecting pathogens without the need for laboratory equipment are disclosed. The kits and methods described herein allow for near-room temperature amplification of pathogen...
US20180031733 Biodegradable Oceanic Drifter Tracking Device  
A water body drifter device for tracking movement of a fluid is disclosed. The drifter may include a floater assembly having a toroid shaped buoy fixedly connected to a floater head disposed...
US20180028607 METHODS OF TREATMENT FOR RETINAL DISEASES  
The present invention provides methods of treating a retinal disorder comprising administering an effective amount of a neurotrophic factor to a subject having the retinal disorder. The...
US20180028477 TREATMENT OF CARDIAC REMODELING AND OTHER HEART CONDITIONS  
The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some...
9867923 Reducing soluble urokinase receptor in the circulation  
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuric kidney disease, which comprises both native and transplanted kidneys. Treatment was limited in the past due to the...
9855312 GHRH agonists for the treatment of ischemic disorders  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion...
US20170360837 MATERIALS AND METHODS FOR TREATING ENDOTHELIAL DYSFUNCTION AND METHODS FOR MONITORING EFFICACY OF THERAPY IN A SUBJECT  
The present disclosure is directed to materials and methods for treating endothelial dysfunction in a subject in need thereof. Methods of determining efficacy of treatment are also provided.
9839670 Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins  
This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25...
US20170349878 CELL CULTURE MEDIA  
A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base;...
9825229 Purification of carbon nanotubes via selective heating  
The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein...
US20170291817 Purification of Carbon Nanotubes Via Selective Heating  
The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein...
9777256 Cell culture media  
A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base;...
9764012 Vaccine compositions and methods of use thereof  
Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production,...
US20170252976 Apparatus, system, and method for 4-dimensional molecular printing  
A method and apparatus for 4-dimensional printing are disclosed. The apparatus includes a polymer pen array translatable in three axes, a light source for illuminating the polymer pen array, a...
9750770 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
9737611 Dendrimer conjugates for coating cells  
The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in...
US20170233448 INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USE  
Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising...
US20170226218 Method for In Vivo Expansion of T Regulatory Cells  
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
US20170216240 METHODS FOR MODULATING IKS CHANNEL ACTIVITY  
Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate Iks channels to treat conditions associated with a disruption in Iks channel...
US20170202907 Materials and Methods of Treating Dyslipidemia  
Described herein are materials and methods for treating dyslipidemia in a mammalian subject in need thereof comprising administering a growth hormone-releasing hormone (GHRH) antagonist or variant...
US20170191058 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...
9683217 In vitro culture conditions for T-cell acute lymphoblastic leukemia/lymphoma  
We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially T-cell acute...
US20170165336 METHODS AND COMPOSITIONS FOR TRANSGENE EXPRESSION IN A HERPESVIRUS VECTOR SYSTEM  
Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous recombinant transgene of interest encoding an...
9672394 System and method for securing backscatter wireless communication  
A system and method for securing backscatter communication. In one embodiment, a backscatter communication system includes a reader. The reader is configured to receive backscatter transmissions....
US20170147743 RAPID IDENTIFICATION OF PHARMACOLOGICAL TARGETS AND ANTI-TARGETS FOR DRUG DISCOVERY AND REPURPOSING  
A computing system automatically analyzes various drug or other compound targets using biologic activity data for cellular proteins, and develops a target/anti-target matrix identifying...
US20170146526 COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS  
Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the...
US20170145110 ANTIBODY-ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
US20170107277 METHODS OF MODULATING INFLAMMASOME ACTIVITY TO TREAT INFLAMMATORY CONDITIONS  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
9611313 Antibody-endostatin fusion protein and its variants  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
9603925 Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20170082625 METHOD AND SYSTEM FOR MICROFILTER-BASED CAPTURE AND RELEASE OF CANCER ASSOCIATED CELLS  
A slotted microfilter is coated with a phase changeable material having a hydrophobic state under a first temperature and a hydrophilic state under a second temperature. An example coating...
US20170080027 EXPANDED UTILITY OF RED-CELL DERIVED MICROPARTICLES (RMP) FOR TREATMENT OF BLEEDING  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as...
US20170074849 A TEST STRIP FOR MELAMINE DETECTION  
Described here is a test strip for detection of melamine, comprising: a support configured for capillary flow of a fluid sample from a first end of the support to a second end of the support that...
US20170065233 Image Guided Small Animal Stereotactic Radiation Treatment System  
A dual, imaging and radiation system provides for finely aligned movement of a subject through the use of a computer controlled mounting stage having separate, non-gantry translational and...
US20170058259 CELL CULTURE MEDIA  
A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base;...
US20170037400 MODULATING IMMUNE RESPONSES  
Modulators of STING are able to upregulate or down regulate immune responses. Administration of such modulators can be used to treat diseases or other undesireable conditions in a subject either...
US20170003303 Innate Immune Proteins As Biomarkers for CNS Injury  
The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein...
9533013 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
9512209 Methods of modulating inflammasome activity to treat inflammatory conditions  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...