Patents and Patent Applications from University of Miami


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9512209 Methods of modulating inflammasome activity to treat inflammatory conditions  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
US20160341728 BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
US20160339043 COMPOSITIONS AND METHODS FOR REDUCING INTRAOCULAR PRESSURE  
Compositions, kits, and methods for reducing intraocular pressure (IOP) in a subject (e.g., human) include at least one naturally occurring or synthesized version or analog thereof of a lipid...
9499627 Method for in vivo expansion of T regulatory cells  
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
9486645 Radiation therapy device for ocular melanoma  
The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through...
9486521 Therapeutic applications targeting SARM1  
The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM)...
US20160305942 METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS AND PROVIDING PROGNOSIS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.
9468677 Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20160271083 TREATMENT OF CARDIAC REMODELING AND OTHER HEART CONDITIONS  
The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some...
9447160 Compositions, methods and kits for treatment of cancer and autoimmune diseases  
The present invention is directed to fusion proteins having an IL-21 cytokine portion and an anti-CD20 antibody portion, and methods of using such fusion proteins. The invention also provides...
US20160263051 STABLE LIQUID FORMULATIONS OF VOLATILE GAS ANESTHETICS  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
US20160250303 PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION  
Methods and compositions are provided to modulate the activity of Perforin-2. Provided herein are various components of the Perforin-2 activation pathway. In specific embodiments, inhibitors of...
US20160243218 INHIBITION OF NONSENSE MEDIATED DECAY PATHWAYS  
Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions comprise one or more cell binding...
US20160235289 RETINAL NERVE FIBER LAYER VOLUME ANALYSIS FOR DETECTION AND PROGRESSION ANALYSIS OF GLAUCOMA  
Techniques are provided that detect the onset and/or progression of glaucoma from analyzing the area and or volume of suppression and inferior retinal nerve fiber layers.
9394526 FROG/TOAD conditionally silenced vectors for hypoxia gene therapy  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under...
9393271 GHRH agonists for islet cell transplantation and function and the treatment of diabetes  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve...
US20160187343 COMPOSITIONS AND METHODS FOR IDENTIFYING A RISK OF CANCER IN A SUBJECT  
Disclosed herein are compositions and methods for determining a risk of cancer, such as head and neck squamous cell carcinoma, in a subject using a bodily fluid sample from the subject and assays...
US20160184363 METHOD FOR ISOLATION AND PURIFICATION OF MICROVESICLES FROM CELL CULTURE SUPERNATANTS AND BIOLOGICAL FLUIDS  
The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles...
US20160166652 NOVEL N- AND C-TERMINAL SUBSTITUTED ANTAGONISTIC ANALOGS OF GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
9358231 Type II RAF kinase inhibitors  
The present invention relates to novel compounds which are able to modulate b-raf kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.
US20160146819 CLASSIFICATION SYSTEM, METHODS AND KIT FOR CLASSIFYING, PREDICTING AND TREATING BREAST CANCER  
A novel classification system for breast cancer based on normal breast cell phenotypes and various expression levels of estrogen receptor (ER), androgen receptor (AR), and vitamin D receptor...
US20160143939 COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF CARDIOVASCULAR,IMMUNOLOGICAL AND INFLAMMATORY DISEASES  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20160133843 PURIFICATION OF CARBON NANOTUBES VIA SELECTIVE HEATING  
The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein...
US20160102365 ASSAYS, METHODS AND KITS FOR ANALYZING SENSITIVITY AND RESISTANCE TO ANTI-CANCER DRUGS, PREDICTING A CANCER PATIENT'S PROGNOSIS, AND PERSONALIZED TREATMENT STRATEGIES  
Described herein are assays, methods and kits for analyzing sensitivity of a subject's cancerous tumor to a drug, predicting responses of cancerous tumors to drugs, determining the prognosis of a...
9308269 Stable liquid formulations of volatile gas anesthetics  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
9308083 Corneal implant and method of delivering a corneal implant  
A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in...
US20160058798 METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY ENDOSCOPIC-MEDIATED (OR LAPAROSCOPIC-MEDIATED) TRANSPLANTATION OF STEM CELLS INTO/ONTO BILE DUCT WALLS OF PARTICULAR REGIONS OF THE BILIARY TREE  
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem...
US20160054299 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...
US20160045583 Tumor Vaccine  
The invention relates to the fields of medicine, immunology, and oncology. More specifically, the invention relates to methods and compositions for inducing an immune response against a tumor in...
9260504 N- and C-terminal substituted antagonistic analogs of GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
US20160039936 FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITION FOR THE TREATMENT OF DISEASE  
Methods of inhibiting fibroblast growth factor mediated activation of fibroblast growth factor receptors for the treatment of chronic kidney disease, diabetes, obesity, and cardiac diseases are...
US20160030588 IMMUNE-POTENTIATING DRUG NANOCARRIERS AND METHODS OF PRODUCTION AND USE THEREOF  
Described herein are nanoparticle-based compositions, kits, methods and platforms for delivering drugs to professional APCs (PAPCs) in vivo resulting in a robust and specific immune response to a...
9248144 Compositions, kits and methods for treatment of cardiovascular, immunological and inflammatory diseases  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20160022748 Recombinant VSV for the Treatment of Tumor Cells  
The present invention relates to compositions and methods for the treatment of tumor and/or malignant and/or cancerous cells. The present invention provides VSV vectors comprising nucleic acid...
US20160022635 USE OF ARGININE VASOPRESSIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PROSTATE CANCER  
Described herein are methods of decreasing the proliferation of prostate cancer cells in a mammalian subject by administering to a subject in need thereof a composition comprising an AVPR...
US20160015779 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS, AND IMMUNOTOXINS  
This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25...
9238064 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20150374848 Methods for the Treatment of Head and Neck Squamous Cell Carcinoma  
This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease...
9217696 Ultra-rapid diagnostic tissue preparation as an alternative to frozen section  
Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a...
US20150359861 ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF  
The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose,...
9205135 Podocyte pH modulation and uses thereof  
Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
9198872 Dendritic and hyperbranched polymers for cellular encapsulation and functionalization  
A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers...
US20150322410 HYPOXIA REGULATED CONDITIONALLY SILENCED AAV EXPRESSING ANGIOGENIC INDUCERS  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under...
US20150315573 METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION  
Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g.,...
9175254 Enhanced oxygen cell culture platforms  
Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both...
9155830 Device for radiation-activated localized delivery of treatment agents  
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the...
9155764 Expanded utility of red-cell derived microparticles (RMP) for treatment of bleeding  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can be considered as universal...
US20150274798 NOVEL GH-RH ANALOGS WITH POTENT AGONISTIC EFFECTS  
There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their...
9144594 Cathepsin L mediated diseases and associated methods and products  
This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays...
US20150252080 FUSION PROTEINS FOR PROMOTING AN IMMUNE RESPONSE, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF MAKING AND USE THEREOF  
Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine adjuvants against cancer (e.g.,...