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Patents and Patent Applications from University of Miami


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US20140243264 METHODS OF TREATMENT FOR RETINAL DISEASES  
The present invention provides methods of treating a retinal disorder comprising administering an effective amount of a neurotrophic factor to a subject having the retinal disorder. The...
US20140220155 VAGINAL TISSUE REJUVENATION COMPOSITIONS AND METHODS  
A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as...
US20140220016 ANTIBODY- ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
8792349 Concurrent association of a wireless mobile node with access points for increasing capacity of access points  
Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.
US20140206836 NOVEL N- AND C-TERMINAL SUBSTITUTED ANTAGONISTIC ANALOGS OF GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
8785178 Perifusion device  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
8777084 Anastomosis system and method  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20140193410 Compositions and Methods for the Regulation of T Regulatory Cells Using TL1A-Ig Fusion Protein  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20140193378 GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve...
8771680 Topical co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20140179604 GHRH AGONISTS FOR THE TREATMENT OF ISCHEMIC DISORDERS  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion...
8754059 Use of miR-30e to treat vascular lesions  
MicroRNA molecules are directed to the treatment of diseases associated with plaque formation, cardiovascular diseases, inflammation, stroke, and disorders associated with aging.
8754013 Open-reading-frame (ORF) phage display  
A dual display phage system for the identification of protein interaction networks and therapeutic targets.
8728520 Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same  
A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material...
US20140121221 SELECTIVE PDE4 B INHIBITION AND IMPROVEMENT IN COGNITION IN SUBJECTS WITH BRAIN INJURY  
Provided herein are methods of improving cognitive ability or memory in a subject that has suffered a brain injury or spinal cord injury by administering a selective PDE4 B inhibitor.
8702684 Therapeutic hybrid implantable devices  
A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and...
8697597 Self sustained electrochemical promotion catalysts  
A method and system for the reduction of pollutant NOx gases from automobile exhaust, as well as a method of reforming hydrocarbons, using a self-sustaining catalyst comprising an ion conductive...
8691942 N- and C- terminal substituted antagonistic analogs of GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
8685400 Modulating inflammasome activity and inflammation in the central nervous system  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
8685384 Recombinant cancer cell secreting modified heat shock protein-antigenic peptide complex  
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic...
US20140088177 RECOMBINANT VSV FOR THE TREATMENT OF TUMOR CELLS  
Vesicular Stomatitis Viruses expressing foreign nucleic acid sequences were highly attenuated but were lytic for abnormal cells, such as cancers, infected cells. Methods of treatment include the...
US20140083945 Reducing Soluble Urokinase Receptor in the Circulation  
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuric kidney disease, which comprises both native and transplanted kidneys. Treatment was limited in the past due to the...
8679426 Microscope accessory and microplate apparatus for measuring phosphorescence and cellular oxygen consumption  
A microplate apparatus having a bottom plate defining a plurality of very small microwells (for example, each having a volume of 0.02 or less) for containing sample material and a top plate...
US20140079712 Therapeutic Applications Targeting SARM1  
The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM) ...
US20140074147 CLOT CAPTURE DEVICE  
A system and method for preventing the movement of emboli away from a vascular region. The system generally includes a medical device having a clot capture assembly, a shaft, and a sheath disposed...
US20140058068 Novel GH-RH analogs with potent agonistic effects  
There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their...
US20140057847 CARDIOPROTECTIVE EFFECTS OF GHRH AGONISTS  
Disclosed herein are methods demonstrating that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent...
US20140037682 HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY  
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients...
8641193 Spectral contrast for glaucoma imaging  
A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes...
US20140024042 BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
US20140023627 TOPICAL CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20140023621 BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR  
Methods for the isolation of CD271+ stem cell populations are important in the prevention or treatment of cardio-vascular diseases and repair of cardiac tissue. The methods are applicable to stem...
8609617 KLF family members regulate intrinsic axon regeneration ability  
This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like ...
8606346 Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital X-ray system during thermotherapy  
A method of thermally inducing and monitoring changes to localized regions of tissue by illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed...
US20130316011 Expanded Utility of Red Cell-Derived Microparticles (RMP) for Treatment of Bleeding  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as...
8586030 Co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20130302293 COMPOSITIONS, CELLS, KITS AND METHODS FOR AUTOLOGOUS STEM CELL THERAPY  
Described herein are compositions, kits and methods for stimulating angiogenic functions of stem cells and/or progenitor cells having pro-angiogenic potential (e.g., endothelial progenitor cells...
8562976 Co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
8551770 Enhanced oxygen cell culture platforms  
Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides...
US20130261058 ACCELERATION OF WOUND HEALING BY GROWTH HORMONE RELEASING HORMONE AND ITS AGONISTS  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
US20130261055 Novel N- and C- terminal substituted antagonistic analogs of GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 96) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
US20130243724 COMPOSITIONS AND METHODS FOR INDUCING MIGRATION BY DENDRITIC CELLS AND AN IMMUNE RESPONSE  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
US20130237442 Methods and Compositions for Diagnosis of Non-Viable Early Pregnancy  
Methods and compositions are provided for diagnosing an abnormal early pregnancy in a mammalian subject by contacting a biological sample of the subject with a reagent that enables measurement of...
US20130236437 COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF CARDIOVASCULAR, IMMUNOLOGICAL AND INFLAMMATORY DISEASES  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20130236433 METHODS, COMPOSITIONS, CELLS, AND KITS FOR TREATING ISCHEMIC INJURY  
The methods, compositions, cells and kits described herein are based on the discovery that stem cells, when injected into ischemic tissue of mammals, can be protected by preconditioning of the...
US20130226292 ISLET STORING INTRAOCULAR IMPLANT, METHOD OF USING THE SAME AND KIT INCLUDING THE SAME  
An intraocular implant that has an anterior portion, at least one haptic element designed to localize the intraocular implant within an eye, a posterior portion, and an islet storage feature...
US20130224237 INHIBITION OF NONSENSE MEDIATED DECAY PATHWAYS  
Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions comprise one or more cell binding ligands...
US20130224108 Methods for the Treatment of Head and Neck Squamous Cell Carcinoma  
This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease...
US20130212125 BIOINFORMATICS SEARCH TOOL SYSTEM FOR RETRIEVING AND SUMMARIZING GENOTYPIC AND PHENOTYPIC DATA FOR DIAGNOSING PATIENTS  
A computer system having a processor, non-transitory memory and a communication system is described. The communication system is coupled to a network and communicates with one or more genetic...
US20130209514 APTAMER-TARGETED COSTIMULATORY LIGAND APTAMER  
Compositions for inducing or enhancing immunogenicity of a tumor comprise bi- and multi-specific aptamers binding to a tumor cell and an immune cell. These compositions have broad applicability in...
Matches 1 - 50 out of 449 1 2 3 4 5 6 7 8 9 >