Patents: University of Miami

Patents and Patent Applications from University of Miami

Matches 1 - 50 out of 323

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Match	Document	Document Title
1	US20130089594	MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can...
2	US20130040324	PERIFUSION DEVICE A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
3	US20130039933	STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
4	8357701	Galactokinase inhibitors Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
5	8354379	Peptides that enhance acetylcholinesterase expression The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful...
6	8348128	Anastomosis system and method A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
7	US20120328673	DENDRITIC AND HYPERBRANCHED POLYMERS FOR CELLULAR ENCAPSULATION AND FUNCTIONALIZATION A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers...
8	US20120328629	Therapeutic Applications Targeting SARM1 The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM) ...
9	US20120328559	Compositions and Methods for Treating Inflammatory Lung Disease The invention provides a method of modulating a T cell immune response by modulating DR3 function in the T cell, wherein the T cell response causes a symptom of inflammatory lung disease. The...
10	US20120321645	Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins Compositions and methods utilizing immunomodulating agents can either stimulate or indirectly augment the immune system or have an immunosuppressive effect. TNFR25 agonists disclosed herein have an...
11	US20120308647	USE OF MIR-30E TO TREAT VASCULAR LESIONS MicroRNA molecules are directed to the treatment of diseases associated with plaque formation, cardiovascular diseases, inflammation, stroke, and disorders associated with aging.
12	8318212	Cartilage composition and process for producing the cartilage composition Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a...
13	US20120294808	Fluorescent Analogs of Neurotransmitters, Compositions Containing the Same and Methods of Using the Same A method of imaging using selective fluorescent emitters and compositions for imaging are described. The method can include contacting a specimen with a composition comprising at least one...
14	8304537	Use of oxazine compounds for making chromogenic materials Heterocyclic compounds incorporating a [1,3]oxazine ring may be used to make chromogenic materials. These molecules switch from a colorless state to a colored form upon addition of either acid or...
15	8293227	Topical co-enzyme Q10 formulations and methods of use Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
16	US20120263740	APTAMER-TARGETED SIRNA TO INHIBIT NONSENSE MEDIATED DECAY Compositions for inducing or enhancing antigenicity of a target cell by modulating the non-sense mediated decay pathway in the target cell. The compositions comprise one or more aplamers providing...
17	8288168	Simplified tissue processing Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two...
18	US20120251527	PODOCYTE SPECIFIC ASSAYS AND USES THEREOF Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
19	8263389	Perifusion device A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
20	8262031	Co-flow jet aircraft The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
21	US20120225084	KLF FAMILY MEMBERS REGULATE INTRINSIC AXON REGENERATION ABILITY This invention relates, e.g., to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like ...
22	8257929	Gene expression profiling of Parkinson's Disease The present invention identifies the changes in gene expression associated with Parkinson's Disease by examining multiregional gene expression from normal brain and brain of Parkinson's Disease....
23	US20120219542	PODOCYTE PH MODULATION AND USES THEREOF Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
24	8252768	Designer therapy of pancreatic tumors Chemotherapeutic and Radiation sensitizing agents which target tumor cells, specifically, based on the elevation of enzyme pathways, provide highly selective drug therapy. These agents are combined...
25	8252209	Photochromic compounds based on ring opening and closing of an [1,3]oxazine compound We have designed a molecular switch based on the photoinduced opening and thermal closing of a [1,3]oxazine ring. A substituted [1,3]oxazine compound described as having a general (i.e.,...
26	8242167	Mannose derivatives for killing tumor cells A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells,...
27	8227421	Fluorinated GHRH antagonists Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...
28	8227405	Fluorinated GHRH antagonists Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...
29	8221996	High quality, continuous throughput, tissue processing A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one...
30	8210792	Wind energy system A method and system for harvesting wind energy. The system may include a wind turbine disposed subjacent to a roof assembly of building. A plurality of conduits are adjacent to and extending below...
31	8207142	Inhibitor of DNA methylation Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions...
32	US20120153188	MICROSCOPE ACCESSORY AND MICROPLATE APPARATUS FOR MEASURING PHOSPHORESCENCE AND CELLULAR OXYGEN CONSUMPTION A device and system that allows an inverted microscope with a movable x-y stage to also function as a time-resolved plate reader. The device, which is sized to fit into the condenser holder of an...
33	US20120152403	MICROSCOPE ACCESSORY AND MICROPLATE APPARATUS FOR MEASURING PHOSPHORESCENCE AND CELLULAR OXYGEN CONSUMPTION A microplate apparatus having a bottom plate defining a plurality of very small microwells (for example, each having a volume of 0.02 or less) for containing sample material and a top plate...
34	US20120150029	System and Method for Detection and Monitoring of Ocular Diseases and Disorders using Optical Coherence Tomography A system for the imaging, processing and evaluation of tissues provides prognostic and diagnostic details regarding diseased tissue. A set of quantitative measures were developed and integrated in...
35	8198436	Colorimetric detection of cyanide with a chromogenic oxazine A chromogenic oxazine compound for the colorimetric detection of cyanide was designed. Indeed, the [1,3]oxazine ring of our compound opens to form a phenolate chromophore in response to cyanide....
36	8198099	Mechanism to signal receptor-ligand interactions with luminescent quantum dots Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging...
37	US20120142544	DIAGNOSTIC TRANSCRIPTOMIC BIOMARKERS IN INFLAMMATORY CARDIOMYOPATHIES Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
38	US20120135011	Method for in vivo expansion of T regulatory cells Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
39	US20120129199	COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the...
40	US20120115165	BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
41	US20120114729	SILICONE-PEROXIDE COMPOSITIONS FOR LONG-TERM, CONTROLLED OXYGEN RELEASE A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The...
42	US20120101375	INTRAOPERATIVE MONITORING OF TEMPERATURE-INDUCED TISSUE CHANGES WITH A HIGH-RESOLUTION DIGITAL X-RAY SYSTEM DURING THERMOTHERAPY A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed...
43	US20120093761	VACCINE COMPOSITIONS AND METHODS OF USE THEREOF Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production,...
44	US20120088739	METHOD FOR TREATING MEIBOMIAN GLAND DISEASE A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the...
45	8156168	Method and system for data security A method, system and apparatus that advantageously provide a security protocol for data security. The apparatus includes a random number generator for generating random numbers and a share...
46	8153436	Assays for disease-associated crystals in biological samples Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging...
47	8147825	Topical co-enzyme Q10 formulations and methods of use Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
48	US20120071911	SPHERICAL HELIX EMBOLIC COILS FOR THE TREATMENT OF CEREBRAL ANEURYSMS A method and device for occluding an aneurysm. The device may include a wire having a shape memory. The wire may define a coil. The wire may further define a first substantially spherical helix and...
49	US20120070511	MITOCHONDRIAL INHIBITORS AND USES THEREOF Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate...
50	US20120055810	SOLID-STATE ELECTROCHEMICAL SENSOR A method and system for corrosion detection. The system may comprise an electrochemical sensor having a working electrode, a reference electrode, a counter electrode, and a polymer electrolyte film...

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