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Patents and Patent Applications from University of Miami


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US20150139952 METHODS, COMPOSITIONS, CELLS, AND KITS FOR TREATING ISCHEMIC INJURY  
The methods, compositions, cells and kits described herein are based on the discovery that stem cells, when injected into ischemic tissue of mammals, can be protected by preconditioning of the...
US20150139904 Dendrimer Conjugates for Coating Cells  
The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in...
US20150132266 NON-EXPANDED POST-NATAL MULTILINEAGE-INDUCIBLE CELLS  
A method of isolating non-expanded post-natal multilineage-inducible cells has the steps of obtaining a biological sample from an animal; isolating bone marrow from the biological sample, isolating...
US20150119557 IN VITRO CULTURE CONDITIONS FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA  
We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially T-cell acute...
9017679 Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins  
Compositions and methods utilizing immunomodulating agents can either stimulate or indirectly augment the immune system or have an immunosuppressive effect. TNFR25 agonists disclosed herein have an...
8992023 Indices for management of dry eye syndrome, corneal ectasia, keratoplasty graft rejection and failure and Fuchs' dystrophy  
Improved indices for the diagnosis and evaluation of conditions affecting the eye. Specifically, the indices include an Enhanced Epithelial Irregularity Factor (eEIF) for the diagnosis and...
US20150086584 MULTI-SPECIFIC BINDING AGENTS  
Compositions comprising aptamers or other binding ligands provide immune cell regulatory signals and specificity to secreted cell molecules at in vivo foci of immune activity.
8986725 Silicone-peroxide compositions for long-term, controlled oxygen release  
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The...
8980249 Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
8974059 Retinal imaging system for the mouse or rat or other small animals  
A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included...
8968720 Heat shock protein GP96 vaccination and methods of using same  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
US20150044180 ISOLATION AND USE OF PLURIPOTENT STEM CELL POPULATION FROM ADULT NEURAL CREST-DERIVED TISSUES  
The present invention relates to methods of isolating a substantially homogeneous population of pluripotent stem cells from adult neural crest tissue (e.g., periodontal ligament) as well as...
US20150044134 COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASES  
The present invention is directed to fusion proteins having an IL-21 cytokine portion and an anti-CD20 antibody portion, and methods of using such fusion proteins. The invention also provides...
8932575 Compositions and methods for inducing migration by dendritic cells and an immune response  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
US20150005876 CORNEAL IMPLANT AND METHOD OF DELIVERING A CORNEAL IMPLANT  
A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in...
US20140358011 SINGLE SHOT HIGH RESOLUTION CONJUNCTIVAL SMALL VESSEL PERFUSION METHOD FOR EVALUATING MICROVASCULATURE IN SYSTEMIC AND OCULAR VASCULAR DISEASES  
A system and method for generating high-resolution, small vessel perfusion maps (nCPMs) of the ocular conjunctival microvasculature. Unlike current systems and methods, the present invention allows...
US20140335086 MODIFIED HEAT SHOCK PROTEIN-ANTIGENIC PEPTIDE COMPLEX  
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic...
US20140335062 CO-CULTURED MESENCHYMAL STEM CELLS AND MYOCYTES  
Co-culturing of mesenchymal stem cells or tissues comprising mesenchymal stem cells with myocytes or myocyte containing tissues provide for the long term culture and expansion of myocytes. The...
US20140329710 TRANSCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT IN NEW ONSET HEART FAILURE  
A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and...
US20140329230 METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS AND PROVIDING PROGNOSIS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (HNSCC) in...
8868155 System and method for early detection of diabetic retinopathy using optical coherence tomography  
A system for the imaging, processing and evaluation of tissues provides prognostic and diagnostic details regarding diseased tissue. A set of quantitative measures were developed and integrated in...
8865723 Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury  
Provided herein are methods of improving cognitive ability or memory in a subject that has suffered a brain injury or spinal cord injury by administering a selective PDE4 B inhibitor.
8865427 Perifusion device  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
US20140303546 LASER ASSISTED DELIVERY OF FUNCTIONAL CELLS, PEPTIDES AND NUCLEOTIDES  
The present invention relates to methods, uses, systems and kits for laser-assisted delivery of at least one bioactive agent to a subject. Specifically, laser light is used to create channel(s) in...
US20140302065 SOLUBLE UROKINASE RECEPTOR (SUPAR) IN DIABETIC KIDNEY DISEASE  
Methods and compositions are provided for diagnosing and treating a diabetic kidney disease (DKD) in an individual. In aspects of the methods, the levels of soluble circulating urokinase receptor...
US20140300862 INDICES FOR MANAGEMENT OF DRY EYE SYNDROME, CORNEAL ECTASIA, KERATOPLASTY GRAFT REJECTION AND FAILURE AND FUCHS' DYSTROPHY  
Improved indices for the diagnosis and evaluation of conditions affecting the eye. Specifically, the indices include an Enhanced Epithelial Irregularity Factor (eEIF) for the diagnosis and...
US20140294820 FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITION FOR THE TREATMENT OF DISEASE  
Methods of inhibiting fibroblast growth factor mediated activation of fibroblast growth factor receptors for the treatment of chronic kidney disease, diabetes, and cardiac diseases are enclosed....
US20140286991 COMBINED CELL BASED GP96-IG-SIV/HIV, RECOMBINANT GP120 PROTEIN VACCINATION FOR PROTECTION FROM SIV/HIV  
Compositions are provided comprising heat shock protein, immunoglobulins and retroviral antigens to induce systemic and mucosal immunity to infection from retroviruses such as Human...
US20140286956 MODULATING INFLAMMASOME ACTIVITY AND INFLAMMATION IN THE CENTRAL NERVOUS SYSTEM  
Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury...
US20140286897 Compositions and Methods for the Regulation of T Regulatory Cells Using TL1A-Ig Fusion Protein  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20140271578 RENAL STEM CELLS ISOLATED FROM KIDNEY  
A novel renal precursor cell is identified from kidney tissue. The cell is multipotent capable of forming renal epithelial and endothelial tissues. The cell can be amplified in culture and...
US20140256828 STABLE LIQUID FORMULATIONS OF VOLATILE GAS ANESTHETICS  
A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general...
US20140255372 CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20140255353 COMPOSITIONS, KITS AND METHODS FOR TREATING OBESITY, DIABETES AND HYPERGLYCEMIA  
Described herein are compositions, kits and methods for treating and preventing obesity and overweight, as well as treating and preventing hyperglycemia, in a subject (e.g., a human), based on the...
US20140243264 METHODS OF TREATMENT FOR RETINAL DISEASES  
The present invention provides methods of treating a retinal disorder comprising administering an effective amount of a neurotrophic factor to a subject having the retinal disorder. The...
US20140234895 ULTRA-RAPID DIAGNOSTIC TISSUE PREPARATION AS AN ALTERNATIVE TO FROZEN SECTION  
Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a...
US20140232528 SYSTEM AND METHOD FOR SECURING BACKSCATTER WIRELESS COMMUNICATION  
A system and method for securing backscatter communication. In one embodiment, a backscatter communication system includes a reader. The reader is configured to receive backscatter transmissions....
US20140220155 VAGINAL TISSUE REJUVENATION COMPOSITIONS AND METHODS  
A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as...
US20140220016 ANTIBODY- ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS  
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2 or anti-EGFR antibodies.
8792349 Concurrent association of a wireless mobile node with access points for increasing capacity of access points  
Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.
US20140206836 NOVEL N- AND C-TERMINAL SUBSTITUTED ANTAGONISTIC ANALOGS OF GH-RH  
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc,...
8785178 Perifusion device  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
8777084 Anastomosis system and method  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20140193410 Compositions and Methods for the Regulation of T Regulatory Cells Using TL1A-Ig Fusion Protein  
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also...
US20140193378 GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve...
8771680 Topical co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20140179604 GHRH AGONISTS FOR THE TREATMENT OF ISCHEMIC DISORDERS  
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion...
8754059 Use of miR-30e to treat vascular lesions  
MicroRNA molecules are directed to the treatment of diseases associated with plaque formation, cardiovascular diseases, inflammation, stroke, and disorders associated with aging.
8754013 Open-reading-frame (ORF) phage display  
A dual display phage system for the identification of protein interaction networks and therapeutic targets.
8728520 Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same  
A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material...