Patents and Patent Applications from University of Miami


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9248144 Compositions, kits and methods for treatment of cardiovascular, immunological and inflammatory diseases  
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature...
US20160022748 Recombinant VSV for the Treatment of Tumor Cells  
The present invention relates to compositions and methods for the treatment of tumor and/or malignant and/or cancerous cells. The present invention provides VSV vectors comprising nucleic acid...
US20160022635 USE OF ARGININE VASOPRESSIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PROSTATE CANCER  
Described herein are methods of decreasing the proliferation of prostate cancer cells in a mammalian subject by administering to a subject in need thereof a composition comprising an AVPR...
US20160015779 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS, AND IMMUNOTOXINS  
This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25...
9238064 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20150374848 Methods for the Treatment of Head and Neck Squamous Cell Carcinoma  
This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease...
9217696 Ultra-rapid diagnostic tissue preparation as an alternative to frozen section  
Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a...
US20150359861 ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF  
The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose,...
9205135 Podocyte pH modulation and uses thereof  
Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
9198872 Dendritic and hyperbranched polymers for cellular encapsulation and functionalization  
A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers...
US20150322410 HYPOXIA REGULATED CONDITIONALLY SILENCED AAV EXPRESSING ANGIOGENIC INDUCERS  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under...
US20150315573 METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION  
Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g.,...
9175254 Enhanced oxygen cell culture platforms  
Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both...
9155830 Device for radiation-activated localized delivery of treatment agents  
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the...
9155764 Expanded utility of red-cell derived microparticles (RMP) for treatment of bleeding  
Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can be considered as universal...
US20150274798 NOVEL GH-RH ANALOGS WITH POTENT AGONISTIC EFFECTS  
There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their...
9144594 Cathepsin L mediated diseases and associated methods and products  
This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays...
US20150252080 FUSION PROTEINS FOR PROMOTING AN IMMUNE RESPONSE, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF MAKING AND USE THEREOF  
Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine adjuvants against cancer (e.g.,...
US20150238354 LOCALIZED THERAPEUTIC HYPOTHERMIA SYSTEM, DEVICE, AND METHOD  
Therapeutic application of mild to moderate hypothermia in a medical procedure has been found to provide benefits to patients. For example, application of mild hypothermia in the auditory pathway...
US20150219656 METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS AND PROVIDING PROGNOSIS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.
US20150216651 NOVEL KERATOPROSTHESIS, AND SYSTEM AND METHOD OF CORNEAL REPAIR USING SAME  
A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support....
US20150204845 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...
9079974 GH-RH analogs with potent agonistic effects  
There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their...
US20150185232 INNATE IMMUNE PROTEINS AS BIOMARKERS FOR CNS INJURY  
The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein...
US20150174207 METHODS FOR TREATING CANCER WITH GHRH AGONISTS  
Embodiments of the present disclosure are directed to methods to treat a subject having cancer. In one embodiment, a method of treating a subject with cancer may comprise administering a...
US20150166617 COMPOSITIONS AND METHODS OF TREATING ALZHEIMER'S DISEASE  
Disclosed herein are compositions of GHRH peptide antagonists, and methods to treat Alzheimer's disease and other neurodegenerative disorders. Such compounds are useful for therapeutics, for...
US20150159136 METHODS FOR INDUCING MIGRATION BY DENDRITIC CELLS AND AN IMMUNE RESPONSE  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
US20150157879 RADIATION THERAPY DEVICE FOR OCULAR MELANOMA  
The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through...
US20150157629 TYPE II RAF KINASE INHIBITORS  
The present invention relates to novel compounds which are able to modulate b-raf kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.
US20150139952 METHODS, COMPOSITIONS, CELLS, AND KITS FOR TREATING ISCHEMIC INJURY  
The methods, compositions, cells and kits described herein are based on the discovery that stem cells, when injected into ischemic tissue of mammals, can be protected by preconditioning of the...
US20150139904 Dendrimer Conjugates for Coating Cells  
The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in...
US20150132266 NON-EXPANDED POST-NATAL MULTILINEAGE-INDUCIBLE CELLS  
A method of isolating non-expanded post-natal multilineage-inducible cells has the steps of obtaining a biological sample from an animal; isolating bone marrow from the biological sample,...
US20150119557 IN VITRO CULTURE CONDITIONS FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA  
We describe cell culture media for in vitro culture of a human cancer cell of the lymphocyte lineage (e.g., leukemia, lymphoma, or other blasts) or a precursor thereof, especially T-cell acute...
9017679 Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins  
Compositions and methods utilizing immunomodulating agents can either stimulate or indirectly augment the immune system or have an immunosuppressive effect. TNFR25 agonists disclosed herein have...
8992023 Indices for management of dry eye syndrome, corneal ectasia, keratoplasty graft rejection and failure and Fuchs' dystrophy  
Improved indices for the diagnosis and evaluation of conditions affecting the eye. Specifically, the indices include an Enhanced Epithelial Irregularity Factor (eEIF) for the diagnosis and...
US20150086584 MULTI-SPECIFIC BINDING AGENTS  
Compositions comprising aptamers or other binding ligands provide immune cell regulatory signals and specificity to secreted cell molecules at in vivo foci of immune activity.
8986725 Silicone-peroxide compositions for long-term, controlled oxygen release  
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein....
8980249 Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
8974059 Retinal imaging system for the mouse or rat or other small animals  
A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included...
8968720 Heat shock protein GP96 vaccination and methods of using same  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
US20150044180 ISOLATION AND USE OF PLURIPOTENT STEM CELL POPULATION FROM ADULT NEURAL CREST-DERIVED TISSUES  
The present invention relates to methods of isolating a substantially homogeneous population of pluripotent stem cells from adult neural crest tissue (e.g., periodontal ligament) as well as...
US20150044134 COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASES  
The present invention is directed to fusion proteins having an IL-21 cytokine portion and an anti-CD20 antibody portion, and methods of using such fusion proteins. The invention also provides...
8932575 Compositions and methods for inducing migration by dendritic cells and an immune response  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
US20150005876 CORNEAL IMPLANT AND METHOD OF DELIVERING A CORNEAL IMPLANT  
A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in...
US20140358011 SINGLE SHOT HIGH RESOLUTION CONJUNCTIVAL SMALL VESSEL PERFUSION METHOD FOR EVALUATING MICROVASCULATURE IN SYSTEMIC AND OCULAR VASCULAR DISEASES  
A system and method for generating high-resolution, small vessel perfusion maps (nCPMs) of the ocular conjunctival microvasculature. Unlike current systems and methods, the present invention...
US20140335086 MODIFIED HEAT SHOCK PROTEIN-ANTIGENIC PEPTIDE COMPLEX  
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic...
US20140335062 CO-CULTURED MESENCHYMAL STEM CELLS AND MYOCYTES  
Co-culturing of mesenchymal stem cells or tissues comprising mesenchymal stem cells with myocytes or myocyte containing tissues provide for the long term culture and expansion of myocytes. The...
US20140329710 TRANSCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT IN NEW ONSET HEART FAILURE  
A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and...
US20140329230 METHODS FOR DETECTING HUMAN PAPILLOMAVIRUS AND PROVIDING PROGNOSIS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA  
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (HNSCC)...
8868155 System and method for early detection of diabetic retinopathy using optical coherence tomography  
A system for the imaging, processing and evaluation of tissues provides prognostic and diagnostic details regarding diseased tissue. A set of quantitative measures were developed and integrated in...