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Patents and Patent Applications from University of Miami


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US20120101375 INTRAOPERATIVE MONITORING OF TEMPERATURE-INDUCED TISSUE CHANGES WITH A HIGH-RESOLUTION DIGITAL X-RAY SYSTEM DURING THERMOTHERAPY  
A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed...
US20120093761 VACCINE COMPOSITIONS AND METHODS OF USE THEREOF  
Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production,...
US20120088739 METHOD FOR TREATING MEIBOMIAN GLAND DISEASE  
A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the...
8156168 Method and system for data security  
A method, system and apparatus that advantageously provide a security protocol for data security. The apparatus includes a random number generator for generating random numbers and a share...
8153436 Assays for disease-associated crystals in biological samples  
Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging...
8147825 Topical co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20120071911 SPHERICAL HELIX EMBOLIC COILS FOR THE TREATMENT OF CEREBRAL ANEURYSMS  
A method and device for occluding an aneurysm. The device may include a wire having a shape memory. The wire may define a coil. The wire may further define a first substantially spherical helix...
US20120070511 MITOCHONDRIAL INHIBITORS AND USES THEREOF  
Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate...
US20120055810 SOLID-STATE ELECTROCHEMICAL SENSOR  
A method and system for corrosion detection. The system may comprise an electrochemical sensor having a working electrode, a reference electrode, a counter electrode, and a polymer electrolyte...
US20120037751 SUPERSONIC FLYING WING  
A bidirectional flying wing maximizes efficiency and reduces sonic boom during supersonic flight. The flying wing has bilateral symmetry across two perpendicular planes and a substantially...
US20120029472 TNFR25 AGONISTS TO ENHANCE IMMUNE RESPONSES TO VACCINES  
TNFR25 compositions enhance the immune response against antigens. Administration of TNFR25 agonists was found to enhance tumor rejection, responses against viral diseases and other infectious...
US20120027670 SELF SUSTAINED ELECTROCHEMICAL PROMOTION CATALYSTS  
A method and system for the reduction of pollutant NOx gases from automobile exhaust, as well as a method of reforming hydrocarbons, using a self-sustaining catalyst comprising an ion conductive...
8105632 Cell-derived microparticles as hemostatic agents for control of hemorrhage and treatment of bleeding disorders  
Compositions comprising membrane-derived and synthetic microparticles that induce platelet aggregation and are useful for treating bleeding disorders, particularly those involving platelet...
8099147 Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital X-ray system during thermotherapy  
A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays...
8097033 Extraocular muscle prosthesis  
A prosthetic device and method to restore extraocular muscle function. The device includes a housing; a biasing component disposed in the housing; a proximal connector operatively connected to a...
US20120006183 AUTOMATIC ANALYSIS AND MANIPULATION OF DIGITAL MUSICAL CONTENT FOR SYNCHRONIZATION WITH MOTION  
Systems and methods are provided for extracting rhythmic chroma information from a signal. A method may perform a process for rhythmic event perception, periodicity estimation, and chroma...
8088591 Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma  
Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid,...
US20110287961 EXPRESSION ANALYSIS OF CORONARY ARTERY ATHEROSCLEROSIS  
This invention relates, e.g., to a method for screening a subject for the presence of coronary atherosclerosis, said method comprising measuring the expression level of at least 5 of the genes of...
US20110287057 Cancer Treatment  
A cell-based vaccine prolongs the survival of cancer patients. The vaccine includes a dose of irradiated cultured lung adenocarcinoma cells (AD100) transfected with HLA A1 and gp96-Ig (human gp96...
US20110275931 System and Method for Early Detection of Diabetic Retinopathy Using Optical Coherence Tomography  
A system for the imaging, processing and evaluation of tissues provides prognostic and diagnostic details regarding diseased tissue. A set of quantitative measures were developed and integrated in...
US20110273667 ENHANCED OPTICAL COHERENCE TOMOGRAPHY FOR ANATOMICAL MAPPING  
A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of...
8053241 Arsenic-specific stain for identifying arsenic-treated wood  
A novel reagent is used to identify arsenic-treated wood. The stain may detect arsenic extracted from wood into solution; arsenic transferred from wood to a wipe, which is then extracted into...
US20110262485 STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES  
Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
US20110251236 GALACTOKINASE INHIBITORS  
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
US20110250229 ALLOGENEIC CANCER CELL-BASED IMMUNOTHERAPY  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20110243951 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS AND IMMUNOTOXINS  
It is an object of the invention to provide novel compositions and methods utilizing immunomodulating agents that can either stimulate or indirectly augment the immune system or in other cases...
US20110236397 LIMITED PROTEOLYSIS OF CD2AP AND PROGRESSION OF RENAL DISEASE  
Compositions which specifically block cathepsin L function in podocytes, compositions which protect cytoskeletal adaptor protein (CD2AP) for degradation, compositions which modulate expression or...
US20110236356 METHODS OF ISOLATING AND USING STEM CELLS  
Methods of isolating and using stem cells from neural crest, e.g. periodontal ligament, isolated stem cell and therapeutic cell cultures, and therapeutic applications for a variety of conditions....
US20110234976 RETINAL IMAGING SYSTEM FOR THE MOUSE OR RAT OR OTHER SMALL ANIMALS  
A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included...
US20110228223 SPECTRAL CONTRAST FOR GLAUCOMA IMAGING  
A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes...
US20110223196 HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY  
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients...
US20110212083 ROLE OF SOLUBLE UPAR IN THE PATHOGENESIS OF PROTEINURIC KIDNEY DISEASE  
Compositions which specifically block urokinase receptor (uPAR) in podocytes; compositions which modulate or block soluble urokinase receptor (suPAR); compositions which modulate pathways in which...
US20110210211 DISCRETE CO-FLOW JET (dCFJ) AIRFOIL  
The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
US20110208305 COMPOSITE BONE GRAFTS, PARTICULATE BONE-CALCIUM SULFATE CONSTRUCTS, AND METHODS OF TREATING JOINT INJURIES  
A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible...
US20110207628 OPEN-READING-FRAME (ORF) PHAGE DISPLAY  
A dual display phage system for the identification of protein interaction networks and therapeutic targets.
US20110201008 ASSAYS, METHODS AND KITS FOR MEASURING RESPONSE TO THERAPY AND PREDICTING CLINICAL OUTCOME IN PATIENTS WITH B-CELL LYMPHOMA  
Assays, methods and kits for predicting survival outcome in a subject having diffuse large B-cell lymphoma (DLBCL) and for measuring a subject's response to DLBCL therapy involve specific miRNAs...
US20110195048 REGULATION OF LYMPHOCYTES AND USES THEREFOR  
Compositions comprising TNF receptor super-family member 25 (TNFR25) agents, attenuate Treg activity and, by comparison with other TNFR members, only weakly costimulates T effector cell (Teff)...
US20110184298 PORTABLE CARDIO WAVEFORM ACQUISITON AND HEART RATE VARIABILITY (HRV) ANALYSIS  
A system and method for measuring heart rate variability (HRV). The system includes at least one biosensor operable to measure at least one signal from the heart. A bioamplifier is also included,...
US20110183926 TREATMENT USING CONTINUOUS LOW DOSE APPLICATION OF SUGAR ANALOGS  
Methods and uses of low dosage nonmetabolizable D-glucose analogs and mannose analogs such as 2-deoxy-D-glucose, 5-thio-D-glucose, 2-fluoro-2-deoxy-D-glucose, 2-chloro-2-deoxy-D-glucose,...
US20110183922 PEPTIDES THAT ENHANCE ACETYLCHOLINESTERASE EXPRESSION  
The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful...
US20110182866 ISOLATION OF STEM CELL PRECURSORS AND EXPANSION IN NON-ADHERENT CONDITIONS  
Stem cells and compositions thereof are isolated, cultured and expanded. Culture conditions and methods of culturing the isolated stem cells provide non-adherent stem cells which are...
US20110171211 HEAT SHOCK PROTEIN GP96 VACCINATION AND METHODS OF USING SAME  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
US20110149739 CONCURRENT ASSOCIATION OF A WIRELESS MOBILE NODE WITH ACCESS POINTS FOR INCREASING CAPACITY OF ACCESS POINTS  
Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.
US20110147411 PINCH MANIFOLD  
The present invention includes substance delivery control system having a first conduit defining a lumen for the passage of a substance therethrough; a first delivery control element defining a...
US20110123441 NOVEL GREB1A MONOCLONAL ANTIBODY  
The generation and validation of a novel monoclonal GREB1 antibody (GREB1ab). Methods for the prognosis, diagnosis, assessment of disease progression, severity and outcome utilize GREB1 molecules...
US20110108602 ANASTOMOSIS SYSTEM AND METHOD  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20110095243 Photochromic compounds based on ring opening and closing of an [1,3]oxazine compound  
We have designed a molecular switch based on the photoinduced opening and thermal closing of a [1,3]oxazine ring. A substituted [1,3]oxazine compound described as having a general (i.e.,...
7924429 Enhanced optical coherence tomography for anatomical mapping  
A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of...
7910359 Hybrid device for cell therapies  
A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and...
US20110066230 Fluorinated GHRH Antagonists  
Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...