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Patents and Patent Applications from University of Miami


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8053241 Arsenic-specific stain for identifying arsenic-treated wood  
A novel reagent is used to identify arsenic-treated wood. The stain may detect arsenic extracted from wood into solution; arsenic transferred from wood to a wipe, which is then extracted into...
US20110262485 STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES  
Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
US20110251236 GALACTOKINASE INHIBITORS  
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
US20110250229 ALLOGENEIC CANCER CELL-BASED IMMUNOTHERAPY  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20110243951 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS AND IMMUNOTOXINS  
It is an object of the invention to provide novel compositions and methods utilizing immunomodulating agents that can either stimulate or indirectly augment the immune system or in other cases have...
US20110236397 LIMITED PROTEOLYSIS OF CD2AP AND PROGRESSION OF RENAL DISEASE  
Compositions which specifically block cathepsin L function in podocytes, compositions which protect cytoskeletal adaptor protein (CD2AP) for degradation, compositions which modulate expression or...
US20110236356 METHODS OF ISOLATING AND USING STEM CELLS  
Methods of isolating and using stem cells from neural crest, e.g. periodontal ligament, isolated stem cell and therapeutic cell cultures, and therapeutic applications for a variety of conditions....
US20110234976 RETINAL IMAGING SYSTEM FOR THE MOUSE OR RAT OR OTHER SMALL ANIMALS  
A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included...
US20110228223 SPECTRAL CONTRAST FOR GLAUCOMA IMAGING  
A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes...
US20110223196 HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY  
Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients...
US20110212083 ROLE OF SOLUBLE UPAR IN THE PATHOGENESIS OF PROTEINURIC KIDNEY DISEASE  
Compositions which specifically block urokinase receptor (uPAR) in podocytes; compositions which modulate or block soluble urokinase receptor (suPAR); compositions which modulate pathways in which...
US20110210211 DISCRETE CO-FLOW JET (dCFJ) AIRFOIL  
The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
US20110208305 COMPOSITE BONE GRAFTS, PARTICULATE BONE-CALCIUM SULFATE CONSTRUCTS, AND METHODS OF TREATING JOINT INJURIES  
A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid...
US20110207628 OPEN-READING-FRAME (ORF) PHAGE DISPLAY  
A dual display phage system for the identification of protein interaction networks and therapeutic targets.
US20110201008 ASSAYS, METHODS AND KITS FOR MEASURING RESPONSE TO THERAPY AND PREDICTING CLINICAL OUTCOME IN PATIENTS WITH B-CELL LYMPHOMA  
Assays, methods and kits for predicting survival outcome in a subject having diffuse large B-cell lymphoma (DLBCL) and for measuring a subject's response to DLBCL therapy involve specific miRNAs...
US20110195048 REGULATION OF LYMPHOCYTES AND USES THEREFOR  
Compositions comprising TNF receptor super-family member 25 (TNFR25) agents, attenuate Treg activity and, by comparison with other TNFR members, only weakly costimulates T effector cell (Teff)...
US20110184298 PORTABLE CARDIO WAVEFORM ACQUISITON AND HEART RATE VARIABILITY (HRV) ANALYSIS  
A system and method for measuring heart rate variability (HRV). The system includes at least one biosensor operable to measure at least one signal from the heart. A bioamplifier is also included,...
US20110183926 TREATMENT USING CONTINUOUS LOW DOSE APPLICATION OF SUGAR ANALOGS  
Methods and uses of low dosage nonmetabolizable D-glucose analogs and mannose analogs such as 2-deoxy-D-glucose, 5-thio-D-glucose, 2-fluoro-2-deoxy-D-glucose, 2-chloro-2-deoxy-D-glucose,...
US20110183922 PEPTIDES THAT ENHANCE ACETYLCHOLINESTERASE EXPRESSION  
The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful...
US20110182866 ISOLATION OF STEM CELL PRECURSORS AND EXPANSION IN NON-ADHERENT CONDITIONS  
Stem cells and compositions thereof are isolated, cultured and expanded. Culture conditions and methods of culturing the isolated stem cells provide non-adherent stem cells which are...
US20110171211 HEAT SHOCK PROTEIN GP96 VACCINATION AND METHODS OF USING SAME  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
US20110149739 CONCURRENT ASSOCIATION OF A WIRELESS MOBILE NODE WITH ACCESS POINTS FOR INCREASING CAPACITY OF ACCESS POINTS  
Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.
US20110147411 PINCH MANIFOLD  
The present invention includes substance delivery control system having a first conduit defining a lumen for the passage of a substance therethrough; a first delivery control element defining a...
US20110123441 NOVEL GREB1A MONOCLONAL ANTIBODY  
The generation and validation of a novel monoclonal GREB1 antibody (GREB1ab). Methods for the prognosis, diagnosis, assessment of disease progression, severity and outcome utilize GREB1 molecules...
US20110108602 ANASTOMOSIS SYSTEM AND METHOD  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20110095243 Photochromic compounds based on ring opening and closing of an [1,3]oxazine compound  
We have designed a molecular switch based on the photoinduced opening and thermal closing of a [1,3]oxazine ring. A substituted [1,3]oxazine compound described as having a general (i.e.,...
7924429 Enhanced optical coherence tomography for anatomical mapping  
A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of...
7910359 Hybrid device for cell therapies  
A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and...
US20110066230 Fluorinated GHRH Antagonists  
Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...
US20110065675 AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS  
Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune...
US20110052705 CARTILAGE COMPOSITION AND PROCESS FOR PRODUCING THE CARTILAGE COMPOSITION  
Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a...
US20110039805 METHOD FOR TREATING MEIBOMIAN GLAND DISEASE  
A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the...
US20110039788 COMPOSITIONS, METHODS AND KITS FOR DETECTING AND TREATING CANCER  
Compositions, kits and methods for inhibiting cancer cell (e.g., breast cancer cell) growth and treating a subject with cancer (e.g., breast cancer) include a therapeutically effective amount of an...
US20110038865 ANTIBODY- ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS  
Chimeric molecules comprising endostatin and all or a portion of a tumor antigen specific binding molecule for use in treating tumors. The chimeric molecule, includes endostatin, endostatin mutants...
US20110036320 WASTE RECOVERY COGENERATOR  
A waste-to-energy cogeneration system is described in various embodiments. The system can convert certain fuel-laden waste to thermal energy and electrical power. In certain embodiments, fuel-laden...
US20110034931 METHOD FOR PREPARING RECIPIENT SITE AND IMPLANTING ALLOGENIC BONE GRAFT  
A method of fixating allogeneic bone to an area of deficient bone in the jaws comprising: exposing the area of deficient bone by incising and retracting soft tissue; selecting a drill bit having a...
US20110027313 VIRAL RECOMBINEERING AND USES THEREOF  
The invention uses recombinant technology to create infectious molecular clones that capture the sequence diversity of viral genes found in natural populations of mixed genotype viruses, such as...
US20110021584 Methods and Assays for Detecting and Treating Hypoglycemia  
Methods for regulating glucagon release and of treating hypoglycemia, and for screening drug candidates for treating hypoglycemia. The methods are useful for treating diabetes mellitus and...
US20110020856 PERIFUSION DEVICE  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
US20110008884 PATHOLOGY GROSSING TOOL, CASSETTE, AND BOARD  
A pathology grossing tool and board are provided for the preparation from a gross tissue of a uniformly thin tissue specimen, which is suitable for processing for histology, histochemistry,...
US20100316622 DIAGNOSIS AND TREATMENT OF CARDIAC DISORDERS  
Nitric oxide synthase deficiency causes diminished ryanodine receptor S-nitrosylation leading to increased diastolic calcium (Ca2+) and reduced intra sarcoplasmic reticulum calcium (Ca2+) content....
US20100310532 GENE TARGETS IN ANTI-AGING THERAPY AND TISSUE REPAIR  
Novel gene and protein targets are described for treatment of cardiac disorders, anti-aging therapies and tissue repair. Identified biomarkers are prognostic of long term survival of patients...
US20100298438 GENE EXPRESSION PROFILING OF PARKINSON'S DISEASE  
The present invention identifies the changes in gene expression associated with Parkinson's Disease by examining multiregional gene expression from normal brain and brain of Parkinson's Disease....
7838040 Method for regenerating cartilage  
Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a...
US20100285132 IMMUNOTHERAPY COMPOSITIONS, METHOD OF MAKING AND METHOD OF USE THEREOF  
The present invention directs to compositions and methods for modulating immune system. One aspect of the present invention relates to a composition comprising FADD-dependent signaling pathway...
US20100272709 CATHEPSIN L MEDIATED DISEASES AND ASSOCIATED METHODS AND PRODUCTS  
This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays are...
US20100260727 METHOD TO AMPLIFY CARDIAC STEM CELLS IN VITRO AND IN VIVO  
Compositions comprising stem cells delivered into infarcted myocardium by endocardial injection, engraft and differentiate into myocytes, endothelial cells, and vascular smooth muscle, and do so...
7807458 Multilineage-inducible cells and uses thereof  
Described herein are post natal, multilineage inducible cells (MIAMI cells). In some examples, the cells are isolated from non fractionated, adult (males and females 3 to 72 years old) human bone...
US20100249403 USE OF OXAZINE COMPOUNDS FOR MAKING CHROMOGENIC MATERIALS  
Heterocyclic compounds incorporating a [1,3]oxazine ring may be used to make chromogenic materials. These molecules switch from a colorless state to a colored form upon addition of either acid or...
US20100247302 WIND ENERGY SYSTEM  
A method and system for harvesting wind energy. The system may include a wind turbine disposed subjacent to a roof assembly of building. A plurality of conduits are adjacent to and extending below...