Patents and Patent Applications from University of Miami


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8507433 Cardioprotective effects of GHRH agonists  
Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here...
US20130203622 TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS  
Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
US20130195807 AGONISTS OF GROWTH HORMONE RELEASING HORMONE AS EFFECTORS FOR SURVIVAL AND PROLIFERATION OF PANCREATIC ISLETS  
Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
US20130190190 MOLECULAR TARGETS FOR MODULATING INTRAOCCULAR PRESSURE AND DIFFERENTIATION OF STEROID RESPONSES VERSUS NON-RESPONDERS  
Molecular biomarkers as indicators of responses to steroids, drug targets, predictors of steroid responses and identification of drugs for modulating intraocular pressure. Kits and methods of...
US20130189237 CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20130184330 COMPOSITIONS AND METHODS FOR INDUCING CANCER CELL DEATH  
Described herein are pharmaceutical compositions including a sugar or mannose analog (e.g., 2-DG) and an inhibitor of at least one of PERK and GCN2 (e.g., an inhibitor of PERK and an inhibitor of...
8485476 Discrete co-flow jet (DCFJ) airfoil  
The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
8484263 Method for keyless protection of data using a local array of disks  
A method secures data in a network. The data includes a data message that has a first bit length. A random number is generated and transformed to create a first pseudo random number. The first...
8475785 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
US20130144212 DEVICE FOR RADIATION-ACTIVATED LOCALIZED DELIVERY OF TREATMENT AGENTS  
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the...
8451584 Solid state energy storage device and method  
A solid state energy storage device has two electrodes, a membrane separator and a solid electrolyte having a substantially solid solvent, a salt and a mediator. The energy storage device stores...
US20130131152 HYPOXIA REGULATED CONDITIONALLY SILENCED AAV EXPRESSING ANGIOGENIC INDUCERS  
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under...
US20130123817 ANASTOMOSIS SYSTEM AND METHOD  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20130089594 MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION  
The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds...
US20130052215 TUMOR VACCINE  
The invention relates to the fields of medicine, immunology, and oncology. More specifically, the invention relates to methods and compositions for inducing an immune response against a tumor in...
US20130040324 PERIFUSION DEVICE  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
US20130039933 STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES  
Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a...
8357701 Galactokinase inhibitors  
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
8354379 Peptides that enhance acetylcholinesterase expression  
The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful...
8348128 Anastomosis system and method  
A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to...
US20120328673 DENDRITIC AND HYPERBRANCHED POLYMERS FOR CELLULAR ENCAPSULATION AND FUNCTIONALIZATION  
A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers...
US20120328629 Therapeutic Applications Targeting SARM1  
The present disclosure provides methods for reducing axonal and/or synaptic degradation in neurons by modulating sterile α/Armadillo/Toll-Interleukin receptor homology domain protein (SARM)...
US20120328559 Compositions and Methods for Treating Inflammatory Lung Disease  
The invention provides a method of modulating a T cell immune response by modulating DR3 function in the T cell, wherein the T cell response causes a symptom of inflammatory lung disease. The...
US20120321645 Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins  
Compositions and methods utilizing immunomodulating agents can either stimulate or indirectly augment the immune system or have an immunosuppressive effect. TNFR25 agonists disclosed herein have...
US20120308647 USE OF MIR-30E TO TREAT VASCULAR LESIONS  
MicroRNA molecules are directed to the treatment of diseases associated with plaque formation, cardiovascular diseases, inflammation, stroke, and disorders associated with aging.
8318212 Cartilage composition and process for producing the cartilage composition  
Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a...
US20120294808 Fluorescent Analogs of Neurotransmitters, Compositions Containing the Same and Methods of Using the Same  
A method of imaging using selective fluorescent emitters and compositions for imaging are described. The method can include contacting a specimen with a composition comprising at least one...
8304537 Use of oxazine compounds for making chromogenic materials  
Heterocyclic compounds incorporating a [1,3]oxazine ring may be used to make chromogenic materials. These molecules switch from a colorless state to a colored form upon addition of either acid or...
8293227 Topical co-enzyme Q10 formulations and methods of use  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20120263740 APTAMER-TARGETED SIRNA TO INHIBIT NONSENSE MEDIATED DECAY  
Compositions for inducing or enhancing antigenicity of a target cell by modulating the non-sense mediated decay pathway in the target cell. The compositions comprise one or more aplamers providing...
8288168 Simplified tissue processing  
Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two...
US20120251527 PODOCYTE SPECIFIC ASSAYS AND USES THEREOF  
Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
8263389 Perifusion device  
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the...
8262031 Co-flow jet aircraft  
The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about...
US20120225084 KLF FAMILY MEMBERS REGULATE INTRINSIC AXON REGENERATION ABILITY  
This invention relates, e.g., to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like...
8257929 Gene expression profiling of Parkinson's Disease  
The present invention identifies the changes in gene expression associated with Parkinson's Disease by examining multiregional gene expression from normal brain and brain of Parkinson's Disease....
US20120219542 PODOCYTE PH MODULATION AND USES THEREOF  
Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of...
8252768 Designer therapy of pancreatic tumors  
Chemotherapeutic and Radiation sensitizing agents which target tumor cells, specifically, based on the elevation of enzyme pathways, provide highly selective drug therapy. These agents are...
8252209 Photochromic compounds based on ring opening and closing of an [1,3]oxazine compound  
We have designed a molecular switch based on the photoinduced opening and thermal closing of a [1,3]oxazine ring. A substituted [1,3]oxazine compound described as having a general (i.e.,...
US20120213775 TREATMENT OF RENAL DISEASES  
Compositions for the treatment of renal diseases and disorders utilize agents which inhibit alphaV integrin molecules in vivo. Methods of treatment include use of these agents in the prevention...
8242167 Mannose derivatives for killing tumor cells  
A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells,...
US20120201801 TOPICAL CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
US20120195876 NOVEL ROLE OF ALPHA-GALACTOSIDASE ACTIVITY AS A BIOMARKER IN KIDNEY DISEASE  
Biomarkers for diagnosis and differentiation between stages of kidney diseases. Methods of treatments and identification of novel therapies are provided.
8227421 Fluorinated GHRH antagonists  
Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...
8227405 Fluorinated GHRH antagonists  
Novel fluorinated synthetic analogs of hGH-RH(1-30)NH2 that inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a...
8221996 High quality, continuous throughput, tissue processing  
A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one...
8210792 Wind energy system  
A method and system for harvesting wind energy. The system may include a wind turbine disposed subjacent to a roof assembly of building. A plurality of conduits are adjacent to and extending below...
US20120164215 TOPICAL CO-ENZYME Q10 FORMULATIONS AND METHODS OF USE  
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin...
8207142 Inhibitor of DNA methylation  
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions...
US20120153188 MICROSCOPE ACCESSORY AND MICROPLATE APPARATUS FOR MEASURING PHOSPHORESCENCE AND CELLULAR OXYGEN CONSUMPTION  
A device and system that allows an inverted microscope with a movable x-y stage to also function as a time-resolved plate reader. The device, which is sized to fit into the condenser holder of an...