Patents and Patent Applications from University of Massachusetts


Match Document Document Title
9841430 Fractional C-reactive protein (fracCRP) antibodies and assays  
Antibodies and antigen-binding fragments of antibodies that bind to human fractional C-Reactive Protein (fracCRP), kits containing these antibodies and antibody fragments, and assays using these...
US20170349950 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF  
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell...
US20170349911 CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF  
The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In...
US20170348362 ANTHELMINTIC PROBIOTIC COMPOSITIONS AND METHODS  
Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering...
9828600 Compositions and methods for constructing cDNA libraries that allow for mapping the 5′ and 3′ ends of RNAs  
This disclosure provides methods and compositions for preparing and constructing cDNA libraries.
US20170336564 ULTRALOW-ENERGY ELECTRO-OPTICAL LOGIC AND NxN SWITCHING BY RESONANT ON-CHIP NANOBEAM WAVEGUIDE NETWORKS  
An ultralow-energy electro-optical 2×2 cross-bar switch comprises an identical pair of semiconductor nanobeams that are incorporated in the central arms of a waveguided Mach-Zehnder...
US20170336102 Enhanced Thermal Stability on Multi-Metal Filled Cermet Based Spectrally Selective Solar Absorbers  
A spectrally selective solar absorber is described and comprises a substrate, double cermet layers comprising multi-metal nanoparticles embedded in a dielectrics matrix, and double antireflection...
US20170335315 MAPPING OF GENOMIC INTERACTIONS  
The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.
US20170333490 TARGETING EPIGENETIC REGULATORS USING A BACTERIAL DELIVERY SYSTEM  
One embodiment provides an attenuated Salmonella strain comprising a lysis gene or cassette operably linked to an intracellularly induced Salmonella promoter. In one embodiment, the promoter is a...
US20170333363 POLYMERS AND POLYMERIC NANOGELS WITH HYDROPHILICS ENCAPSULATION AND RELEASE CAPABILITIES AND METHODS THEREOF  
The invention provides pH- or redox-responsive and charge-neutral polymeric nanogels that stably encapsulate a biomolecule at one pH or redox condition and then release it at a different pH or...
US20170333348 MASS PRODUCTION AND SIZE CONTROL OF NANOPARTICLES THROUGH CONTROLLED MICROVORTICES  
Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such...
9822372 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
9822205 Deoxybenzoin-derived anti-flammable polymers  
The invention provides novel flame-retardant polymers and materials, their synthesis and use. More particularly, the flame-retardant polymers are deoxybenzoin-derived polymers.
US20170331096 ELECTRICAL INSULATION LAYER AND BATTERY DEVICE  
An electrical insulation layer including microparticles and having a mesoporous structure; and a battery device including a cathode, an anode, an electrical insulation layer including...
US20170327843 Mouse Model of Alpha-One Antitrypsin (AAT) Deficiency  
Transgenic non-human animals, e.g., rodents, e.g., mice comprising genomic mutations that inactive all of the serpinlA genes and thus lack any functional serpinA1 genes. As a result of the genomic...
US20170327822 RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
US20170326523 MICRO- AND NANO-PARTICLES WITH VARIABLE SURFACE MORPHOLOGIES AND METHODS OF MAKING SAME  
According to various aspects and embodiments, multilayer particles having an irregular surface architecture and methods of making the same are disclosed.
US20170326071 YEAST CELL WALL PARTICLES FOR RECEPTOR-TARGETED NANOPARTICLE DELIVERY  
The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to...
9815912 Hydrophilic modification of water insoluble polysaccharide as surface-active agents  
A surfactant produced by reacting naturally occurring polysaccharides that are not water soluble with a hydrophilic substituent on a carboxylic portion of the polysaccharide. In a second reaction,...
9814787 Luciferin amides  
This disclosure relates to luciferin amides of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to detect fatty acid amide...
9809817 Oligonucleotide compounds for targeting huntingtin mRNA  
This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
9809720 Ferroelectric nanocomposite based dielectric inks for reconfigurable RF and microwave applications  
A novel ferroelectric ink comprising multiphase Barium Strontium Titanate (BST) in a polymer composite is described. The ink can be employed using direct-ink writing techniques to print high...
9808936 Two-phase gripper to reorient and grasp  
Two-phase gripper. The gripper reorients and grasps an object while being picked up. The gripper includes a parallel jaw gripper including a pair of opposed, two-phase fingers, each finger...
9808557 Tubular silk compositions and methods of use thereof  
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily...
US20170317887 VERSIONING SYSTEM FOR NETWORK STATES IN A SOFTWARE-DEFINED NETWORK  
A versioning system for network state of a network includes: a server, configured to execute a versioning controller, the versioning controller being configured to communicate with a plurality of...
US20170312367 BRANCHED OLIGONUCLEOTIDES  
Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
US20170312210 BOTULINUM NANOEMULSIONS  
The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle...
US20170306403 Molecular Diagnosis of FSHD By Epigenetic Signature  
The present invention includes methods of determining whether an individual in need thereof has, or is at risk of developing, facioscapulohumeral muscular dystrophy (FSHD).
US20170306278 DEVICE FOR CONTROLLED APICAL FLOW IN CELL CULTURE INSERTS  
A device for controlling apical flow to a cell culture includes an apical insert that defines at least one inlet channel extending from an inlet port to an apical feed port and at least one outlet...
US20170306189 HIGH CAPACITY EASY RELEASE EXTENDED USE ADHESIVE DEVICES  
The invention provides novel devices, systems, designs, materials and fabrication methods that enable high-load capacity, easy release, and suitable for extended/repeated use in a variety of...
US20170306183 FABRICATION OF MICRO- AND NANO-PARTICLE COATED MATERIALS  
According to various aspects and embodiments, materials having a modified surface to increase hydrophobicity and methods of making the same are disclosed. In accordance with one or more aspects, a...
US20170306084 DEOXYBENZOIN CONTAINING FLAME RETARDANT POLYMER COMPOSITIONS  
The present invention relates to specific deoxybenzoin containing flame retardant polyesters and flame retardant thermoplastic polymer molding compositions comprising deoxybenzoin containing flame...
US20170304428 Compositions and Methods for Increasing Immunogenicity of Glycoprotein Vaccines  
The present invention relates to the microbial immunogens engineered to bear α-gal epitope(s) for induction of potent humoral and cellular immune responses when administered to subjects having...
US20170304207 MANUFACTURE OF A PHARMACEUTICAL PRODUCT  
An emulsion-based method for the manufacture of a crystalized spherical agglomerate and/or a pharmaceutical product is provided; and crystalized spherical agglomerates and/or pharmaceutical...
9796980 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway  
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
9795689 Crosslinked polymer nano-assemblies and uses thereof  
The invention provides powerful methods and compositions for designing, selecting, fine-tuning and optimizing polymer nanogel and other supramolecular assemblies for various properties including,...
US20170298917 Solid State Pump Using Electro-Rheological Fluid  
The systems and methods described herein are directed towards a solid state pumping system that utilizes an electric field applied across a channel formed within the solid state pump to move...
US20170296732 System And Method For Inertial Focusing Microfiltration For Intra-Operative Blood Salvage Autotransfusion  
A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear...
US20170296159 SURGICAL RETRACTION DEVICE  
A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision...
US20170296139 DEVICES AND METHODS FOR MEASURING VASCULAR DEFICIENCY  
The present invention relates to devices and methods for measuring vascular deficiency using Doppler ultrasound detection. Embodiments can be used to monitor the condition of surgical tissue flaps...
9790102 Multi-stage bubble column humidifier  
A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a...
9789485 Micro-fluidic device and uses thereof  
A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a...
9789091 Methods of inhibiting cataracts and presbyopia  
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and...
9788589 Flexible, fibrous energy managing composite panels  
A flexible, fibrous energy managing composite panel includes multiple flocked energy absorbing material (FEAM) layers separated by dividers. The FEAM layers can be single side or double side and...
US20170292104 MICROFLUIDIC SYSTEM AND METHOD FOR PERFUSION BIOREACTOR CELL RETENTION  
A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. At least one...
9781949 Antimicrobial delivery systems, methods of manufacture, and methods of use thereof  
Disclosed herein is an antimicrobial delivery system comprising an electrostatic complex comprising cationic biopolymer and an anionic biopolymer, wherein the antimicrobial delivery system has...
US20170288281 LITHIUM METAL ELECTRODES AND BATTERIES THEREOF  
The present disclosure is generally related to separators for use in lithium metal batteries, and associated systems and products. Certain embodiments are related to separators that form or are...
US20170288112 Fabrication of Stable Electrode/Diffusion Barrier Layers for Thermoelectric Filled Skutterudite Devices  
Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of CoSi2 and a dopant are ball-milled to form a...
US20170283355 UNSATURATED DEOXYBENZOIN COMPOUND, POLYMER PREPARED THEREFROM, AND ARTICLES COMPRISING THE POLYMER  
An unsaturated deoxybenzoin compound has the structure (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are defined herein. A polymer including at least one group derived from a deoxybenzoin...
US20170282147 NANOSTRUCTURED APPARATUS AND METHODS FOR PRODUCING CARBON-CONTAINING MOLECULES AS A RENEWABLE ENERGY RESOURCE  
Nanostructured arrays having a metal catalyst (e.g., cobalt) are irradiated with light to initiate the an artificial photosynthetic reaction resulting in the formation of carbon-containing...