Patents and Patent Applications from University of Massachusetts


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US20170298917 Solid State Pump Using Electro-Rheological Fluid  
The systems and methods described herein are directed towards a solid state pumping system that utilizes an electric field applied across a channel formed within the solid state pump to move...
US20170296732 System And Method For Inertial Focusing Microfiltration For Intra-Operative Blood Salvage Autotransfusion  
A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear...
US20170296159 SURGICAL RETRACTION DEVICE  
A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision...
US20170296139 DEVICES AND METHODS FOR MEASURING VASCULAR DEFICIENCY  
The present invention relates to devices and methods for measuring vascular deficiency using Doppler ultrasound detection. Embodiments can be used to monitor the condition of surgical tissue flaps...
9790102 Multi-stage bubble column humidifier  
A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a...
9789485 Micro-fluidic device and uses thereof  
A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a...
9789091 Methods of inhibiting cataracts and presbyopia  
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and...
9788589 Flexible, fibrous energy managing composite panels  
A flexible, fibrous energy managing composite panel includes multiple flocked energy absorbing material (FEAM) layers separated by dividers. The FEAM layers can be single side or double side and...
US20170292104 MICROFLUIDIC SYSTEM AND METHOD FOR PERFUSION BIOREACTOR CELL RETENTION  
A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. At least one...
9781949 Antimicrobial delivery systems, methods of manufacture, and methods of use thereof  
Disclosed herein is an antimicrobial delivery system comprising an electrostatic complex comprising cationic biopolymer and an anionic biopolymer, wherein the antimicrobial delivery system has...
US20170288281 LITHIUM METAL ELECTRODES AND BATTERIES THEREOF  
The present disclosure is generally related to separators for use in lithium metal batteries, and associated systems and products. Certain embodiments are related to separators that form or are...
US20170288112 Fabrication of Stable Electrode/Diffusion Barrier Layers for Thermoelectric Filled Skutterudite Devices  
Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of CoSi2 and a dopant are ball-milled to form a...
US20170283355 UNSATURATED DEOXYBENZOIN COMPOUND, POLYMER PREPARED THEREFROM, AND ARTICLES COMPRISING THE POLYMER  
An unsaturated deoxybenzoin compound has the structure (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are defined herein. A polymer including at least one group derived from a deoxybenzoin...
US20170282147 NANOSTRUCTURED APPARATUS AND METHODS FOR PRODUCING CARBON-CONTAINING MOLECULES AS A RENEWABLE ENERGY RESOURCE  
Nanostructured arrays having a metal catalyst (e.g., cobalt) are irradiated with light to initiate the an artificial photosynthetic reaction resulting in the formation of carbon-containing...
US20170281838 NEGATIVE PRESSURE WOUND CLOSURE DEVICES AND METHODS  
Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of non-planar wounds such as amputation wounds. The devices and...
9780240 Backside configured surface plasmonic structure for infrared photodetector and imaging focal plane array enhancement  
The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to...
US20170276643 COULOMETRIC MICROFLUIDIC SENSORS USING A SILVER BAND ELECTRODE, AND METHODS THEREOF  
The invention provides novel microfluidic coulometric sensors having a silver (Ag) band electrode longitudinally placed in a microchannel affording visual readout suitable for the naked eye, and...
9773151 System and methods for contactless biometrics-based identification  
The present invention relates generally to a system and methods that facilitates the identification of an individual through the use of data. Certain more particular embodiments of the present...
9771590 Targeting hepatitis B virus (HBV) host factors  
Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and...
9771442 Polymerization initiating system and method to produce highly reactive olefin functional polymers  
A method for producing highly reactive olefin polymers wherein at least 50 mol % of the polymer chains have terminal double bonds, and a novel polymerization initiating system for accomplishing...
9770511 Protein transduction domains mimics  
The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers)...
9770222 Apparatus and method for X-ray-based breast imaging  
The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast...
US20170271201 METHOD OF MANUFACTURING A GERMANIUM-ON-INSULATOR SUBSTRATE  
A method of manufacturing a germanium-on-insulator substrate is disclosed. The method comprises: providing (102) a first semiconductor substrate, and a second semiconductor substrate formed with a...
US20170266317 Synthetically Functionalized Living Cells for Targeted Drug Delivery  
Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining...
9765106 Neisseria gonorrhoeae therapeutic based on CMP-nonulosonate sugars  
N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogs to counter gonococcal complement evasion. The nonulosonate...
US20170263385 HYDROPHILIC CONJUGATED POLYMERS, AND METHODS OF PREPARATION AND USE THEREOF  
The invention provides novel hydrophilic conjugated polymers, e.g., hydrophilic poly(arylene vinylenes) or PAVs, and preparation thereof, and methods and devices for their application in...
US20170260351 POROUS MATERIAL AND METHODS OF MAKING AND OF USING THE SAME  
In an embodiment, a porous material comprises a base polymer having a continuous pore structure. In another embodiment, a method of making the porous material comprises reacting a base polymer...
US20170258892 COMPOSITIONS AND METHODS TO TREAT AIDS  
Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid...
US20170258796 Methods And Compositions To Reduce Oxidative Stress  
The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the...
US20170258571 COMPOSITE COMPRISING FABRIC AND POLYAMPHOLYTE HYDROGEL AND PREPARATION METHOD THEREOF  
A composite containing a fabric and a polyampholyte hydrogel is provided. In the composite, the polyampholyte hydrogel is a hydrogel of a polymer containing randomly dispersed cationic and anionic...
D797284 Surgical forceps  
9759370 Devices for application and load bearing and method of using the same  
Gecko-like adhesive application devices suited for dynamic applications are disclosed, where the device can be easily applied to target substrates, exhibiting a firm hold, and subsequently...
9757339 Artificial cell constructs for cellular manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20170255857 BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTERS  
Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs...
US20170252365 IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF  
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of...
US20170248831 MULTI-MODE CAVITIES FOR HIGH-EFFICIENCY NONLINEAR WAVELENGTH CONVERSION FORMED WITH OVERLAP OPTIMIZATION  
A dual frequency optical resonator configured for optical coupling to light having a first frequency ω1. The dual frequency optical resonator includes a plurality of alternating layer pairs...
US20170248610 METHOD OF PREDICTING OBESITY  
The presently disclosed subject matter relates to a method for predicting increased risk of obesity on a non-obese subject. More particularly, the presently disclosed subject matter relates to a...
US20170247257 Fabrication of Carbon Nanoribbons from Carbon Nanotube Arrays  
Inter-allotropic transformations of carbon are provided using moderate conditions including alternating voltage pulses and modest temperature elevation. By controlling the pulse magnitude,...
US20170246351 Biocompatible Textile Sleeves to Support and Guide Muscle Regeneration and Methods of Use Thereof  
A biocompatible sleeve designed to encase an assembly of small 3D muscles that have been cultured in vitro. The sleeve is formed from polymer fibers in such a way that pushing the two ends of the...
9746356 Sensor, method for forming the same, and method of controlling the same  
According to embodiments of the present invention, a sensor for determining a flow parameter of a fluid is provided. The sensor includes a polymer membrane, an elongate microstructure extending...
US20170241982 MULTI-WELL QUARTZ CRYSTAL MICROBALANCE MASS AND VISCOELASTIC SENSOR  
In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators....
US20170239377 MOLECULAR PROBES FOR MULTIMODALITY IMAGING AND TRACKING OF STEM CELLS  
The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes...
US20170238660 HIGH CAPACITY EASY RELEASE EXTENDED USE ADHESIVE CLOSURE DEVICES  
Unique designs, devices, systems, materials and fabrication methods are provided including adhesive closure devices that are easily released and are suitable for extended/repeated use in a variety...
US20170233517 Amphiphilic Graft Copolymers  
A novel amphiphilic graft copolymer is described. A process to make amphiphilic graft copolymers via grafting either poly(ethylene oxide) or polylactide side chains onto an EVA platform using...
US20170232439 SEPARATION OF LOW-ABUNDANCE CELLS FROM FLUID USING SURFACE ACOUSTIC WAVES  
An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided....
US20170231905 METHODS OF INHIBITING CATARACTS AND PRESBYOPIA  
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and...
US20170231587 APPARATUS AND METHOD FOR X-RAY-BASED BREAST IMAGING  
The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast...
US20170227531 METHODS FOR ISOLATING ENDOGENOUS NUCLEIC ACIDS FROM SUBCELLULAR COMPARTMENTS WITHOUT FRACTIONATION  
Methods of determining subcellular localization of nucleic acids, including RNA and DNA are described. In particular, the invention relates to a method combining proximity-specific labeling with...
US20170226561 MAPPING THE SPATIAL LOCALIZATION OF CELLULAR NUCLEIC ACIDS BY PROXIMITY-DEPENDENT ENZYMATIC TAGGING  
Compositions and methods for mapping the spatial localization of cellular nucleic acids by proximity-dependent enzymatic tagging are described. In particular, proximity-specific biotinylation of...
US20170226193 ANTI-OSPA ANTIBODIES AND METHODS OF USE  
The invention provides anti-OspA antibodies and methods of using the same.