Patents and Patent Applications from University of Massachusetts


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10024723 Detection of electromagnetic radiation using nonlinear materials  
An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate....
10021861 Genetically modified non-human animals and methods relating to innate immune system response detection  
Described herein are immunodeficient non-human animals lacking expression of toll-like receptor 4 (TLR4) by endogenous autogeneic innate immune cells, as well as methods and compositions for...
US20180198256 Method for High-Concentration Doping of Germanium with Phosphorous  
In a method for electrically doping a semiconducting material, a layer of germanium is formed having a germanium layer thickness, while in situ incorporating phosphorus dopant atoms at a...
US20180197999 HIGH-LINEARITY TRANSISTORS  
A transistor includes a first gate-controlled region having a first threshold voltage and a second gate-controlled region in parallel with the first gate-controlled region. The second...
US20180197736 SYSTEMS AND METHODS FOR GRAPHENE BASED LAYER TRANSFER  
A graphene-based layer transfer (GBLT) technique is disclosed. In this approach, a device layer including a III-V semiconductor, Si, Ge, III-N semiconductor, SiC, SiGe, or II-VI semiconductor is...
US20180197686 LUBRICANT-IMPREGNATED SURFACES FOR ELECTROCHEMICAL APPLICATIONS, AND DEVICES AND SYSTEMS USING THE SAME  
In certain embodiments, the invention relates to an electrochemical device having a liquid lubricant impregnated surface. At least a portion of the interior surface of the electrochemical device...
US20180196058 MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS  
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography...
US20180196040 MEMBRANE AND DROPLET-INTERFACE BILAYER SYSTEMS AND METHODS  
Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.
US20180196025 CHEMICAL SENSOR FOR HEAVY METAL DETECTION  
A chemical sensor for heavy metal detection is provided. The chemical sensor includes an inlet, a chamber in fluid communication with the inlet, and an outlet in fluid communication with the...
US20180195213 Active Woven Materials  
Active fabrics typically include a plurality of fibers. At least one of the fibers exhibits a change in length or width upon exposure to an external stimulus, such as heat, moisture, or light. The...
US20180194106 Active Lattices  
An active lattice capable of self-transforming responsive to a stimulus, such as heat or moisture, includes a plurality of links interconnected to each other at a plurality of nodes. At least a...
US20180194066 SYSTEMS AND METHODS OF MACHINE VISION ASSISTED ADDITIVE FABRICATION  
The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration...
US20180193518 Controllably Degradable Compositions and Methods  
Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an...
US20180192974 Integrated Optical Blocking Filter for Compact X-Ray Imaging Detector  
An x-ray imaging device can include an x-ray detector and an optical-blocking filter. The x-ray detector has an entrance-window surface for receiving x-rays, at least one side surface, and a back...
US20180192961 APPLICATION OF THE EXTREMA DISTORTION METHOD TO OPTIMIZE CONTROL SIGNALS  
A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control...
10020593 System and method for terahertz integrated circuits  
A system that includes an electromagnetic wave transmission structure having a first end and a second end, conducting components, the conducting components selected from at least one of a network...
10017724 Engineering of a novel breast tumor microenvironment on a microfluidic chip  
A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may...
10017520 Myc modulators and uses thereof  
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating...
10017388 Dihydrogen tetrametaphosphate, its derivatives, and preparation thereof  
Dihydrogen metaphosphate can be synthesized via protonation, and can react with a dehydrating agent to afford tetrametaphosphate anhydride. A monohydrogen tetra-metaphosphate organic ester can be...
10016414 Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders  
The instant invention is based, at least in part, on a newly-identified proteasome-independent signaling function of ubiquitinated PSD-95. Mdm2 inhibitors, Mdm4 inhibitors, PSD-95 inhibitors,...
10016364 Compositions and methods for making and using nanoemulsions  
The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of...
10016130 Eye tracker system and methods for detecting eye parameters  
An improved eye tracker system and methods for detecting eye parameters including eye movement using a pupil center, pupil diameter (i.e., dilation), blink duration, and blink frequency, which may...
US20180190973 SYSTEMS AND METHODS OF PREPARING LITHIUM SULFUR ELECTRODE USING SACRIFICIAL TEMPLATE  
Embodiments described herein relate generally to lithium sulfur batteries and methods of producing the same. As described herein, preventing coarsening of sulfur during the well-known...
US20180188151 Method to Distinguish and Analyze White Blood Cells in the Presence of Red Blood Cells  
Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing...
US20180187194 METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA  
The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA...
US20180187186 COMPOSITIONS COMPRISING NUCLEIC ACIDS AND METHODS OF USING THE SAME  
The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or...
US20180187183 DNA MICROSCOPY  
The present invention relates to DNA microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with...
US20180187169 THIOLASE VARIANTS AND METHODS OF USE THEREOF  
Described herein are thiolase variants, cells expressing the thiolase variants, and methods of their use for the biosynthesis of desired products.
US20180187072 LIGANDS FOR SEMICONDUCTOR NANOCRYSALS  
In this invention, polyimidazole ligands (PILs) incorporating pendant imidazole moieties for nanocrystal binding and either sulfonatebetaine, carboxybetaine, or phosphocholinebetaine moieties for...
US20180185791 MITIGATING LEAKS IN MEMBRANES  
Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a...
US20180185513 NANO-FIBULAR NANOPARTICLE POLYMER-DRUG CONJUGATE FOR SUSTAINED DERMAL DELIVERY OF RETINOIDS  
Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically...
US20180185473 LIPID VESICLE COMPOSITIONS AND METHODS OF USE  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
US20180185286 POROUS MATERIALS CONTAINING COMPOUNDS INCLUDING PHARMACEUTICALLY ACTIVE SPECIES  
Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or...
US20180184629 GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS RELATING TO COMPLEMENT DEPENDENT CYTOTOXICITY  
The present invention relates generally to genetically modified non-human animals and immunodeficient non-human animals characterized by restored complement-dependent cytotoxicity, as well as...
10014438 Light emitting device including semiconductor nanocrystals  
A light emitting device includes a semiconductor nanocrystal and a charge transporting layer that includes an inorganic material. The charge transporting layer can be a hole or electron...
10013391 Architecture emulation in a parallel processing environment  
An integrated circuit includes a plurality of processor core. Processing instructions in the integrated circuit includes: managing a plurality of sets of processor cores, each set including one or...
10012657 Optical nanosensors comprising photoluminescent nanostructures  
Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a...
10012569 Microfluidic bubble logic devices  
Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices,...
10011817 Cell rolling separation  
The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and...
10011336 Underwater vehicle design and control methods  
Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.
10011335 Underwater vehicle design and control methods  
Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.
10010709 Composition for on-demand ultrasound-triggered drug delivery  
Injectable or implantable drug delivery systems providing on-demand ultrasound-triggered drug release and methods for controlling the release of drug in a patient are provided herein. The...
US20180184024 METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE (THDR) TIME-DELAY-AND-INTEGRATE (TDI) IMAGING  
In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic...
US20180181540 SYSTEMS AND METHODS FOR DISTRIBUTED SOLUTION OF OPTIMIZATION PROBLEMS  
A framework is presented for designing a class of distributed, asynchronous optimization algorithms realized as signal processing architectures utilizing various conservation principles. The...
US20180180811 WAVEGUIDE FORMATION USING CMOS FABRICATION TECHNIQUES  
Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon...
US20180180364 LIQUID-IMPREGNATED SURFACES, METHODS OF MAKING, AND DEVICES INCORPORATING THE SAME  
The invention is directed to an article with a liquid-impregnated surface, the surface having a matrix of features thereupon, spaced sufficiently close to stably contain a liquid therebetween or...
US20180179547 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20180179546 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS  
This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders...
US20180179501 COMPOSITIONS AND METHODS FOR TRANSIENT DELIVERY OF NUCLEASES  
The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated AAV...
US20180177738 STABILIZED POLYMERIC NANOCAPSULES, DISPERSIONS COMPRISING THE NANOCAPSULES, AND METHODS FOR THE TREATMENT OF BACTERIAL BIOFILMS  
A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of Formula (I) and (II)...