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8185551 |
Disk-resident streaming dictionary
A method, apparatus and computer program product for storing data in a disk storage system is presented. A dictionary data structure is defined and stored on the disk storage system. Key-value...
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8182804 |
Engineered enzymatically active bacteriophages and methods of uses thereof
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also...
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8179026 |
Nanotubes, nanorods and nanowires having piezoelectric and/or pyroelectric properties and devices manufactured therefrom
Disclosed herein is a device comprising a pair of electrodes; and a nanotube, a nanorod and/or a nanowire; the nanotube, nanorod and/or nanowire comprising a piezoelectric and/or pyroelectric...
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8174703 |
Method for fabricating a sensor, a sensor, and a method for sensing
A method for fabricating a sensor, a sensor so fabricated, and a method for sensing a stimulus are provided. The method includes providing an elongated open channel, such as, a V-groove, in a...
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8173618 |
Formulations for reducing neuronal degeneration
Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E,...
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US20120108548 |
MOLECULAR TWEEZERS FOR THE TREATMENT OF AMYLOID-RELATED DISEASES
This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine...
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US20120100583 |
Enzymatic Synthesis of Polymers
The invention relates to new methods of enzymatic synthesis of polymers such as polyorganosilicones and polyesters, and new polymers made by these methods.
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US20120097521 |
NANOSTRUCTURED APPARATUS AND METHODS FOR PRODUCING CARBON-CONTAINING MOLECULES AS A RENEWABLE ENERGY RESOURCE
Nanostructured arrays having a metal catalyst (e.g., cobalt) are irradiated with light to initiate the an artificial photosynthetic reaction resulting in the formation of carbon-containing...
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8163814 |
Process of forming crosslinked copolymer film, crosslinked copolymer film formed thereby, and water purification membrane
Azidoaryl-substituted cyclooctene monomers and synthesized and used in the preparation of various copolymers. Among these copolymers are those prepared from ring-opening metathesis polymerization...
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8163188 |
Article with PHEMA lift-off layer and method therefor
A method of forming a patterned functional layer on a substrate using a poly(hydroxyethyl methacrylate) lift-off layer is described. The method can be used with substrates that would not tolerate...
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US20120094925 |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 FOR TREATMENT OF CANCER
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent...
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8158742 |
Deoxybenzoin-based anti-flammable polyphosphonate and poly(arylate-phosphonate) copolymer compounds, compositions and related methods of use
Deoxybenzoin-phosphonate and other copolymer compounds, compositions and related methods.
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8158603 |
Fragments of secreted frizzled related protein
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of...
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8153739 |
Antimicrobial polymers
The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis...
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8153393 |
Spirolactam targeting compounds and related compounds
Spirolactam targeting compounds, related compounds, uses of such compounds, and methods of making such compounds are disclosed.
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8153119 |
Engineered enzymatically active bacteriophage and methods for dispersing biofilms
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have...
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8147428 |
Device and method for quantifying edema
The preferred embodiments of the present invention are directed at a device that provides a reliable, accurate and quantifiable measure of a patient's edema. The device improves on the current...
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US20120077934 |
Functional Polyisobutylene Based Macromonomers And Methods For Making And Using The Same
A method of synthesizing a functionalized polymer represented by the structural formula (I) comprising a step of reacting a polymer represented by structural formula (II) with a compound Nu1-M to...
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US20120076761 |
Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease
Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the...
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8143339 |
Nanocomposite polymers
Nanocomposite compositions containing a graft polymer and a filler such as nano-sized silica having flame resistant properties are described.
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8143308 |
Synthesis of oligo/poly(catechins) and methods of use
A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a...
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US20120070376 |
YEAST CELL WALL PARTICLES FOR RECEPTOR-TARGETED NANOPARTICLE DELIVERY
The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to...
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8137728 |
Biopolymer encapsulation and stabilization of lipid systems and methods for utilization thereof
An emulsion system and method for controlling the digestion of a fat or an oil component is provided including a substantially hydrophobic food-grade component, and at least one of an emulsifier...
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US20120059240 |
METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF
The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol...
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US20120053220 |
NOVEL LIPOXYGENASE INHIBITORS AS NEUROPROTECTIVE AGENTS
The present invention relates to the identification of inhibitors of lipoxygenase enzymes. Methods are presented for using novel lipoxygenase inhibitors: LOXBlock-1 and LOXBlock-3, and other...
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US20120053081 |
TOLL-LIKE RECEPTOR-BASED BIOSENSORS
Compositions and methods for detecting Toll-like receptor binding to ligands and test compounds are disclosed herein.
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8124349 |
Toll-like receptor assays
Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR...
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US20120046448 |
CHLAMYDOMONAS INTRAFLAGELLAR TRANSPORT 88 (IFT-88)
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of...
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US20120046242 |
MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant ...
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US20120045503 |
Compositions And Methods For Wound Healing
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In...
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8117902 |
Nanopatterned surfaces and related methods for selective adhesion, sensing and separation
The invention is comprised, in part, of a surface that contains more than one component or construct. Such heterogenous surface compositions and configurations, related systems and methods for...
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US20120040916 |
MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
The present invention is directed toward a method of treating a subject for a condition mediated by the Wnt/β-catenin pathway by selecting a subject with a condition mediated by the Wnt/β-catenin p...
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US20120040444 |
METHOD AND APPARATUS FOR PREPARING CELLS FOR MICROTOME SECTIONING AND ARCHIVING NUCLEIC ACIDS AND PROTEINS
A method and apparatus for embedding cells that utilizes a flow-through embedding technique. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from...
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US20120039929 |
NOVEL THERAPY FOR LYSOSOMAL ENZYME DEFICIENCIES
The present invention provides a therapeutic delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload trapping molecule and a payload molecule, wherein the payload...
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US20120034661 |
STRAINS FOR THE PRODUCTION OF FLAVONOIDS FROM GLUCOSE
The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone...
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US20120034597 |
METHODS OF MONITORING TREATMENT OF AVIREMIC HIV-INFECTED PATIENTS
Methods of monitoring the efficacy of intensified highly active anti-retroviral therapy (HAART) treatment in aviremic Human Immunodeficiency Virus (HIV)-infected patients.
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8110560 |
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic s...
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US20120022415 |
MODULAR THERAPEUTIC PRESSURE APPLICATION DEVICES
The invention relates in some aspects to therapeutic pressure application devices and methods of manufacturing and using the same. In some aspects, the devices comprise a support structure shaped...
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8101586 |
Methods and compositions for the treatment of sterile inflammation
Described are methods and compositions that inhibit IL-1 signalling for the treatment of acute inflammatory response to cell necrosis, and the attendant collateral tissue damage.
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8101577 |
Oxidative DNA damage protection
Provided herein are methods of screening compounds, gene sequences, and gene products in bacteria for agents that are protective against oxidative DNA damage in a human or animal. Gene sequences...
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US20120015372 |
METHODS AND COMPOSITIONS FOR PATHOGEN DETECTION USING FLUORESCENT POLYMER SENSORS
Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.
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8096786 |
Three dimensional micro-fluidic pumps and valves
A system is disclosed for the control of fluid flow in a micro-fluidic system, the system having: a substrate; at least one micro-fluidic channel having disposed in a microchannel layer atop the...
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US20120007277 |
DEVICE AND METHOD FOR FORMING MULTILAYERED LAMINATES
Methods and devices for forming a vertically-oriented multilayer laminates, for example, a vertically-oriented multilayer laminates, are provided. The laminates may be fabricated by hardenable...
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8094810 |
Unidirectional proxy re-encryption
A method for performing unidirectional proxy re-encryption includes generating a first key pair comprising a public key (pk) and a secret key (sk) and generating a re-encryption key that changes...
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8093223 |
RIP140 regulation of diabetes
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e.g., diabetes),...
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US20120003630 |
MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC
We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for...
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8088982 |
Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications
One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional...
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US20110319570 |
POLYESTERS WITH GRAFTED ZWITTERIONS
The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by...
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US20110319569 |
ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES
The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic...
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US20110318730 |
MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS
Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and...
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