Patents and Patent Applications from University of Maryland


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8184129 Techniques for 3-D elastic spatial registration of multiple modes of measuring a body  
Techniques for registration of multiple measurement modes of a body include receiving first and second data from different modes. Each includes measured values with coordinate values. For two...
8183354 Virus coat protein/receptor chimeras and methods of use  
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor....
8183211 Pharmaceutical compositions for inhibiting intestinal permeability  
A method for preventing or delaying the onset of autoimmune diseases is disclosed.
8182878 Metal-enhanced fluorescence from plastic substrates  
The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by...
US20120122908 Novel C-4 Substituted Retinoids  
C-4 substituted retinoic acid analogs, synthesis methods of C-4 substituted retinoic acid analogs and methods of using C-4 substituted retinoic acid analogs to treat various cancers and...
US20120122208 Tubular Bioreactor System for Use in Bone and Cartilage Tissue Engineering  
A bioreactor system includes a growth chamber having an inlet, an outlet, and defining a cavity, a media reservoir is in fluid communication with the inlet, and a pump configured to perfuse a media...
US20120119623 LEAD-FREE PIEZOCERAMIC MATERIALS  
The present invention relates to lead-free piezoelectric ceramic materials comprising crystalline (and preferably perovskite crystalline) structures of the formula Bi1-x(RE)xFeO3, where RE is one...
US20120119117 Remote Nanoscale Photochemistry Using Guided Emission in Nanowires  
A method of fabricating a nanodevice includes providing a nanowire having a first portion and a second portion. The nanowire has a polymer coating. A nanostructure is provided that is proximate to...
8180577 Techniques for determining the effects on a system of a component that has four states  
Techniques for determining effects on a biological system include determining rate constants for a particular time interval starting at an initial time. Each rate constant indicates a rate of...
8180126 Detecting meniscal tears in non-invasive scans  
Techniques for automatically detecting meniscus include receiving pixels from a scanning device directed to a knee of a subject. Also received is a region of interest that includes pixels that...
8179440 Method and system for object surveillance and real time activity recognition  
Method and system for objects surveillance and real-time activity recognition is based on analysis of spatio-temporal images of individuals under surveillance where a spatio-temporal volume...
8179025 Lead-free piezoceramic materials  
The present invention relates to lead-free piezoelectric ceramic materials comprising crystalline (and preferably perovskite crystalline) structures of the formula Bi1-x(RE)xFeO3, where RE is one...
US20120115235 ENHANCED CELLULASE EXPRESSION IN S. DEGRADANS  
The invention provides organisms and methods of using and making organisms with enhanced cellulase expression.
US20120112121 EMULSIONS OF HEAT TRANSFER FLUIDS INCLUDING NANODROPLETS TO ENHANCE THERMAL CONDUCTIVITIES OF THE FLUIDS  
A heat transfer fluid emulsion includes a heat transfer fluid, and liquid droplets dispersed within the heat transfer fluid, where the liquid droplets are substantially immiscible with respect to...
8173787 Plant wall degradative compounds and systems  
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
US20120109124 ELECTROSURGICAL ELEMENT AND UTERINE MANIPULATOR FOR TOTAL LAPAROSCOPIC HYSTERECTOMY  
A vaginal cervical retractor used to maneuver and visualize the uterus during various medical examinations and procedures would include an inner tube provided with a movable assembly of plastic...
US20120107952 MICROWAVE-ACCELERATED PLASMONICS  
The present invention relates to systems and methods using microwave accelerated surface plasmonics for the detection of target species, wherein the system has a metallic surface and the system is...
US20120107329 EGFR and PAR2 Regulation of Intestinal Permeability  
The present invention provides methods for diagnosing and treating an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a...
US20120103822 ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS  
Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or...
8163944 Allylic oxidations catalyzed by dirhodium catalysts under aqueous conditions  
The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The...
8152992 Cell-based sensing: biological transduction of chemical stimuli to electrical signals (nose-on-a-chip)  
Methods and compositions for the reliable detection of chemical stimuli using a “nose-on-a-chip” are presented. The invention uses cells sensitive to chemical stimuli and detects and processes the...
8151648 Ultra-miniature fiber-optic pressure sensor system and method of fabrication  
Ultra-miniature surface-mountable Fabry-Perot pressure sensor is constructed on an optical fiber which utilizes a 45° angled fiber tip covered with a reflective layer which steers the optical axis ...
8147828 Methods and compositions for modulation of blood-neural barrier  
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention...
US20120078206 SNAP-ON TWO-PIECE EMERGENCE PROFILE HEALING ABUTMENT  
The present invention relates to an apparatus for the removal and containment of human waste products from the effected area of incontinent patients. The apparatus and process encapsulates the...
US20120076861 MATERIALS AND METHODS FOR THE TREATMENT OF CELIAC DISEASE  
The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject...
US20120076730 PEPTIDES FOR TRANSPORT OF THERAPEUTICS AND THEIR CARRIERS IN MOUSE MODELS AND HUMANS  
A system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids,...
US20120076722 METHODS FOR TREATING CANCERS AND DISEASES ASSOCIATED WITH 4-1BB (CD137) EXPRESSION  
The present invention relates to the role of 4-1BB (CD137) ligand and anti-4-1BB (CD137) antibody in the treatment of cancers and diseases associated with 4-1BB (CD137) expression. More...
8144757 System and method for estimating probabilities of events  
A dual adaptive importance-sampling system and method is provided that can estimate the probability of events by combining dual complementary importance-sampling simulations. The present invention...
8138289 Imprinted polymeric materials for binding various targets such as viruses  
Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (e.g.,...
8137930 Attenuated Salmonella enterica serovar paratyphi A and uses thereof  
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate...
US20120064112 RECOMBINANT NEWCASTLE DISEASE VIRUSES USEFUL AS VACCINES OR VACCINE VECTORS  
The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M genes, and/or between HN and L genes....
US20120064105 Engineered Type IV Pilin of Clostridium difficile  
The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected...
US20120064074 ANTIGEN BINDING DOMAINS  
A process for the production of an antigen specific antigen binding domain using a transformed host containing an expressible DNA sequence encoding the antigen specific antigen binding domain,...
8135602 Techniques for delivering coordination data for a shared facility  
Techniques for delivering data for coordinating multiple party use of a facility include producing conditions data by measuring without human intervention current condition of a facility that is...
8133724 Human androgen receptor alternative splice variants as biomarkers and therapeutic targets  
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen...
US20120053067 METHOD FOR BINDING SITE IDENTIFICATION BY MOLECULAR DYNAMICS SIMULATION (SILCS: SITE IDENTIFICATION BY LIGAND COMPETITIVE SATURATION)  
The invention describes an explicit solvent all-atom molecular dynamics methodology (SILCS: Site Identification by Ligand Competitive Saturation) that uses small aliphatic and aromatic molecules...
US20120046363 DOCOSAHEXAENOIC ACID FOR THE TREATMENT OF HEART FAILURE  
There is currently no completely effective treatment for heart failure. Considering the need for, and current void in the medical field for, a treatment for heart failure, the invention is drawn to...
US20120046324 SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE  
The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.
8114598 High-sensitivity assays for pathogen detection using metal enhanced fluorescence  
The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and/or silver colloids/islands are polynucleotides which...
US20120034620 COMPOSITIONS AND METHODS FOR ADHESION OF INTACT CELLS TO AN APPARATUS  
Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also...
US20120031133 AIR CONDITIONER  
An air conditioner having a refrigeration cycle including a compressor, a radiator, a pressure-reducing device and an evaporator, a total heat exchanger for performing heat-exchange between outdoor...
8110550 HDAC inhibitors and hormone targeted drugs for the treatment of cancer  
The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method...
8110223 Methods for making pharmaceutical dosage forms containing active cushioning components  
Novel methods for making dosages form comprising a cushioning component. The methods of the present invention provides dosage forms which can be compressed to form compressed dosage forms that are...
8110083 Arbitrary and simultaneous control of multiple objects in micro-fluidic systems  
In a microfluidic device, respective motion of a plurality of objects along corresponding trajectories is achieved by determining a force field, such as an underlying fluid flow which, when applied...
US20120029173 ATTENUATED SALMONELLA ENTERICA SEROVAR PARATYPHI A AND USES THEREOF  
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate...
8107703 Quantitative real-time 4D stress test analysis  
Stress test analysis is facilitated through the acquired and manipulated use of a sequence of volumetric data regarding the heart (and may particularly comprise the left ventricle) for the...
8106096 Compositions and methods for treatment of optic nerve diseases  
The present invention provides a method for treating or reducing damage to the optic nerve in a subject comprising administering to the subject a therapeutically effective amount of prostaglandin...
US20120022052 SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE  
The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.
US20120021493 ORGANIC BIOFILM SUBSTRATA AS A MICROBIAL INOCULUM DELIVERY VEHICLE FOR BIOAUGMENTATION OF PERSISTENT ORGANIC POLLUTANTS IN CONTAMINATED SEDIMENTS AND SOILS  
A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1)...
8101424 Bioassays using plasmonic scattering from noble metal nanostructures  
The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic...