Patents and Patent Applications from University of Maryland


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US20170299513 TUNING OF METAL ENHANCED EMISSIONS OF LONG-LIVED LUMINESCENT COMPOUNDS  
The present invention provides for the surface plasmon-enhancement of long lived luminescent compounds, thereby providing for methods and systems having enhanced and controllable rates of the...
US20170299477 Aerosol Collection System and Method  
The present invention relates to systems and methods for collecting and analyzing bioaerosols, including exhaled breath aerosol from a subject. The collection system comprises an inlet portion...
US20170298108 COMPOSITIONS COMPRISING GRIM-19 THERAPEUTICS AND METHODS OF USE  
The present invention provides nucleic acids encoding a fusion protein comprising a nucleotide sequence encoding GRIM-19 or a biologically active fragment or derivative thereof and a nucleotide...
US20170297029 INTEGRATED THERMOPLASTIC CHIP FOR RAPID PCR AND HRMA  
The present invention relates to a microfluidic system including a temperature controller and a thermoplastic microfluidic chip that enables rapid PCR in a PCR chamber of the microfluidic chip....
US20170296555 TARGETING NCCA-ATP CHANNEL FOR ORGAN PROTECTION FOLLOWING ISCHEMIC EPISODE  
The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ...
US20170295014 METHOD AND APPARATUS FOR AUTHENTICATING DEVICE AND FOR SENDING/RECEIVING ENCRYPTED INFORMATION  
Methods and apparatuses for authenticating communication devices and securely transmitting and/or receiving encrypted voice and data information. A biometric scanner, for example a fingerprint...
US20170291930 Histatin-5 Based Synthetic Peptides and Uses Thereof  
Provided herein are synthetic peptides or synthetic fragments thereof based on a Histatin-5 peptide, for example with a sequence DSHAKRHHGYKRKFHEKHHSHRGY (SEQ ID NO: 1). The synthetic peptides or...
9784682 Fluorescence microscope in microwave cavity  
The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction...
US20170283486 STABLE IMMUNOGEN BASED ON INNER DOMAIN OF HIV-1 GP120 FOR INDUCING IMMUNITY AGAINST HIV  
Stable immunogens comprising portions of the inner domain (ID) of the Human Immunodeficiency Virus (HIV-1) gp120 protein are provided. These ID immunogens selectively present the gp120 C1/C2...
9775929 Solution blow spun polymer fibers, polymer blends therefor and methods and use thereof  
Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers...
US20170278431 Central Pressurized Cadaver Model  
Provided are methods for creating a pressurized cadaver model used for surgical procedure training. In the method the internal jugular veins, common carotid arteries, brachial arteries,...
US20170276666 Multi-Functional Fluid Flow Device  
The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at...
US20170269075 BIOMARKERS PREDICTIVE OF LUPUS PROGRESSION AND USES THEREOF  
Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.
US20170266181 NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY  
Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting...
US20170263935 PROTECTION LAYERS FOR METAL ANODES  
A protection layer is formed on a highly-reactive substantially-pure metal anode to a thickness of between 1 nm and 200 nm, inclusive, using atomic layer deposition (ALD). The ALD protection layer...
US20170260240 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS  
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface...
US20170258464 METHOD AND APPARATUS FOR TRANSAPICAL PROCEDURES ON A MITRAL VALVE  
Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral...
9757426 Peptide additives for enhancing acceptance and ingestion of edibles by rodents and uses thereof  
Methods of using of guanylin family peptides to induce food or odor preferences in mammals are provided, along with methods for inducing feeding responses in mammals, and methods of controlling...
9757375 Compounds that inhibit human DNA ligases and methods of treating cancer  
Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA...
US20170257074 LOW-NOISE, ULTRA-LOW TEMPERATURE DISSIPATIVE DEVICES  
A dissipative device has a planar configuration with one or more resistor elements formed on an insulating substrate. Conductors are formed on the insulating substrate and are coupled to the...
US20170252505 ARTIFICIAL LUNG SYSTEM AND ITS METHODS OF USE  
An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator...
US20170248508 METHODS AND DEVICES FOR MULTI-STEP CELL PURIFICATION AND CONCENTRATION  
Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.
US20170247653 COMPOSITIONS AND METHODS FOR COLLECTING ALGAE  
The invention relates to compositions containing Bacillus sp., optionally with magnetite, useful in methods for collecting algae. The invention also relates to methods for collecting algae by...
US20170246477 System and method for optimizing a treatment plan for irradiation therapy using multi-criteria optimization (MCO)  
A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes defining a single objective function based on a plurality of objective functions...
US20170246180 ACYCLIC CUCURBIT[N]URIL TYPE MOLECULAR CONTAINERS TO TREAT INTOXICATION AND DECREASE RELAPSE RATE IN SUBSTANCE ABUSE DISORDERS  
Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of...
US20170246177 Methods of Treating Age-Related Symptoms in Mammals and Compositions therefor  
A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a composition containing an effective amount...
9739784 Giant obscurins and uses thereof in cancer prognosis and therapy  
Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is...
9739741 Tube-in-a-tube electronic sensors  
The present invention is directed to tube-in-a-tube electronic materials and electronic chemical sensors comprising tube-in-a-tube configurations such as covalently functionalized double-walled...
9738709 Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease  
In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been...
9737256 Apparatus and methods for non-invasive assessment of transplant kidney viability  
A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their...
US20170231739 HYBRID SURGICAL MESH  
Disclosed is a hybrid surgical mesh that is partially absorbable or biodegradable. The hybrid surgical mesh described herein generally comprises a central absorbable or biodegradable portion...
US20170226181 SOLUBLE CD80 AS A THERAPEUTIC TO REVERSE IMMUNE SUPPRESSION IN CANCER PATIENTS  
The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune...
US20170224779 METHODS FOR TREATING CARDIOVASCULAR DYSFUNCTION AND IMPROVING FLUID HOMEOSTASIS WITH A PEPTIDE HORMONE  
The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition by administering an ELA peptide or...
9726553 Optical temperature sensor and use of same  
A thermometer includes a substrate; an optical resonator disposed on the substrate and including an optical resonance, the optical resonator being configured to receive a resonant frequency...
9725411 Process for a direct one-pot transformation of lutein to β-cryptoxanthin via its acetate ester  
The present invention relates to a process for converting commercially available lutein and/or lutein esters from extracts of marigold flower petals to (3R)-β-cryptoxanthin (major) and...
9724392 IL-25 treatment of obesity and metabolic disorders  
The present invention provides a method for reducing the weight of a subject, preventing weight gain in a subject, lowering blood glucose, or treating hepatic steatosis, comprising administering...
US20170218049 IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS  
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each...
US20170216479 Compositions comprising textured patterns and methods of using the same  
The invention provides method of guiding unidirectional movement of a cell comprising exposing the cell to a surface comprising an asymmetric, three-dimensional pattern of one or a plurality of...
9719923 Tuning of metal enhanced emissions of long-lived luminescent compounds  
The present invention provides for the surface plasmon-enhancement of long lived luminescent compounds, thereby providing for methods and systems having enhanced and controllable rates of the...
US20170212048 ANALYTE SENSING SYSTEM AND METHOD UTILIZING SEPARATE EQUILIBRIUM AND MEASUREMENT CHAMBERS  
An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly...
US20170211120 Pathogen Identification in Complex Biological Fluids  
Provided herein are methods for rapidly identifying a microbe, such as a pathogen, from a biological sample including, blood, urine, wound effluent, stool, serum, and bronchoalveolar lavage fluid....
US20170211012 METHOD OF EXTRACTING LIPIDS FROM MICROBES  
Improved methods for extracting lipid-containing molecules from microbes are disclosed. The methods utilize selected surfactants for extraction of lipids and lipopolysaccharides from microbes,...
US20170209864 METHODS AND SYSTEMS FOR PROCESSING PARTICLES  
Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical...
US20170209605 CARBOHYDRATE FUNCTIONALIZED CATANIONIC SURFACTANT VESICLES FOR DRUG DELIVERY  
Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.
US20170202968 NOVEL COMPOSITION OF MATTER FOR DELIVERING LIPID-SOLUBLE MATERIALS, AND A METHOD FOR PRODUCING IT  
This invention describes a novel composition of matter describing a complex comprising leaf protein and a lipophilic substance(s), along with the method of producing it. Delivery of lipid-soluble...
US20170202752 PROTEIN-REPELLENT DENTAL MATERIALS AND USE THEREOF IN DENTAL APPLICATIONS  
The present invention provides protein-repellent dental materials that can be widely applied in a variety of dental applications. The protein-repellent dental materials of the invention include...
US20170202536 SYSTEM AND METHOD FOR ASSESSMENT OF CARDIAC STROKE VOLUME AND VOLUME RESPONSIVENESS  
Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid...
US20170198329 DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF AMINOACIDOPATHIES  
The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of...
US20170197087 SYSTEM, APPARATUS AND METHOD FOR TRANSIENT ELECTRIC FIELD DETECTION AND DISPLAY  
Disclosed are systems, devices and methods for detecting and measuring TMS-induced electrical fields. In accordance with certain aspects of an embodiment of the invention, a TMS sensor probe is...
US20170196957 RECOMBINANT T CELL RECEPTOR LIGAND COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CANCER  
Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the...