Patents and Patent Applications from University of Louisville


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US20180200385 ANTI-NUCLEOLIN AGENT-CONJUGATED NANOPARTICLES AS RADIO-SENSITIZERS AND MRI AND/OR X-RAY CONTRAST AGENTS  
A composition comprises an anti-nucleolin agent conjugated to nanoparticles, and optionally containing gadolinium. Furthermore, a pharmaceutical composition for treating cancer comprises a...
10022791 Method for synthesizing self-assembling nanoparticles  
Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an...
US20180193266 EXOSOMAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE  
An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3...
US20180187674 METHOD FOR OPERATING A LINEAR COMPRESSOR  
A method for operating a linear compressor includes establishing a set of predictors, and establishing a model for an estimated head clearance of the linear compressor with the set of predictors....
US20180185512 NANOPARTICLES FOR DRUG DELIVERY  
The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles.
US20180185285 Milk-Derived Microvesicle Compositions and Related Methods  
A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or...
10011820 Adipose stromal vascular fraction cell constructs  
Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing...
US20180182482 COMPUTER AIDED DIAGNOSTIC SYSTEM FOR CLASSIFYING KIDNEYS  
A computer aided diagnostic system and automated method to classify a kidney. Image data for a medical scan that includes image data of a kidney may be received. The kidney image data may be...
US20180179055 METHOD AND DEVICE FOR DETECTING CELLULAR TARGETS IN BODILY SOURCES USING CARBON NANOTUBE THIN FILM  
A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's,...
US20180153917 COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE  
Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about...
9987310 Cardiac progenitor cells and methods of use therefor  
Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (CPCs) and/or progeny cells thereof that are...
US20180147198 COMBINATIONS OF PFKFB3 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS TO TREAT CANCER  
Provided herein is a method of treating cancer and stimulating anti-tumor immunity in a subject in need thereof, the method including administering to the subject a synergistic, therapeutically...
US20180140654 COMPOSITIONS AND METHODS FOR TREATMENT OF ALCOHOL INDUCED LIVER INJURY  
Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related...
US20180116928 COSMETIC COMPOSITIONS CONTAINING QUINONES AND THEIR TOPICAL USE ON SKIN AND HAIR  
Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures...
9943482 Milk-derived microvesicle compositions and related methods  
A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or...
US20180101640 SYSTEM AND METHOD FOR PERSONALIZED DOSING OF PHARMACOLOGIC AGENTS  
A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective...
9931508 Neurostimulator devices using a machine learning method implementing a gaussian process optimization  
Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord;...
9931339 Substituted pyrrolo[2,3-b]quinoxalines for cancer therapy  
Compounds, including quinoxaline derivatives of formula I, for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors such...
US20180088117 Micro-Array Devices for Capturing Cells in Blood and Methods of Their Use  
The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method...
US20180086749 INHIBITORS OF VIRUSES  
The present technology is directed to compounds, compositions, and methods to treat a viral infection. The compound is according to Formula I or a solvate and/or pharmaceutically acceptable salt...
9928347 Computer aided diagnostic system for classifying kidneys  
A computer aided diagnostic system and automated method to classify a kidney. Image data for a medical scan that includes image data of a kidney may be received. The kidney image data may be...
9926194 Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film  
A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's,...
US20180070905 ACCURATE DETECTION AND ASSESSMENT OF RADIATION INDUCED LUNG INJURY BASED ON A COMPUTATIONAL MODEL AND COMPUTED TOMOGRAPHY IMAGING  
A system and computation method is disclosed that identifies radiation-induced lung injury after radiation therapy using 4D computed tomography (CT) scans. After deformable image registration, the...
9914750 Synthetic peptides and peptide mimetics  
The present invention provides Parotid Secretory Protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening GL13 mimetics.
9907958 High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury  
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal...
US20180036232 OPHTHALMIC COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE TO AN EYE LENS  
Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing...
9879324 Genetic determinants of prostate and breast cancer risk  
Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa) or aggressive PCa, or to developing breast cancer (BrCa).
9873878 Compositions and methods for use in treating silicosis and lung cancer  
A method for treating an inflammatory disease is provided. The method comprises administering an effective amount of a BLT1 inhibitor to a subject in need thereof. The BLT1 inhibitor is selected...
US20180016307 GRIFFITHSIN MUTANTS  
The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs,...
US20180009764 METHOD FOR TREATING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS WITH IODO PYRIMIDINE DERIVATIVES  
Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula I: wherein A is selected from the group consisting of aromatic or...
9863002 Genetic determinants of prostate cancer risk  
Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their...
9852267 System and method for personalized dosing of pharmacologic agents  
A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective...
9849193 Nanoparticles for drug delivery  
The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial...
US20170360476 TROCAR FOR IMPROVED FLUID PRESSURE MANAGEMENT DURING ENDOSCOPIC SURGERY  
A trocar for arthroscopy and other endoscopic surgeries is provided, including a diaphragm seal, in which the assembly as a whole provides adequate insufflation of the body compartment during a...
9844514 Methods for treating an established myocardial infarction  
This application discloses methods for treating an established myocardial infarction, including treatment with an epicardial construct containing stromal vascular fraction (SVF) from adipose...
US20170348017 OPEN LOOP POLYPECTOMY SYSTEM  
Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a...
US20170321329 Solar Hydrogen Production from Ambient Water Vapor Electrolysis  
Hydrogen gas as a power source is obtained from gaseous water, including seawater vapor existing abundantly at near-surface levels of the oceans or humid air over land. An integrated system of...
US20170292161 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS USING MICRO RNAs  
Methods of detecting or predicting the presence of colorectal neoplasia are described based on the amounts of particular miRNAs in plasma.
9770587 Neuromuscular stimulation system and method  
Provided are systems and methods employing wide pulse width, high frequency, neuromuscular electrical stimulation (“WPHF-NMES”) for the rehabilitation, treatment or recovery of a subject afflicted...
US20170253758 CORE-SHELL NANOSTRUCTURES AND RELATED INKS, FILMS AND METHODS  
Copper inks are provided that include a plurality of core-shell nanostructures, with each nanostructure including a copper core and a barrier metal shell, a diameter of less than about 500 nm, and...
9755023 Photoelectrochemical cell including Ga(Sbx)N1-x semiconductor electrode  
The composition of matter comprising Ga(Sbx)N1−x where x=0.01 to 0.06 is characterized by a band gap between 2.4 and 1.7 eV. A semiconductor device includes a semiconductor layer of that...
9751950 Methods of reducing skeletal muscle loss using an antibody against Fn14  
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.
US20170250030 METHODS FOR FORMING A PEROVSKITE SOLAR CELL  
A perovskite thin film and method of forming a perovskite thin film are provided. The perovskite thin film includes a substrate, a hole blocking/electron transport layer, and a sintered perovskite...
US20170246809 QUALITY CERTIFICATION METHOD FOR AN ADDITIVE MANUFACTURING PROCESS  
In a quality certification method, a digital, three-dimensional Quality Certificate (3DQC) is created by the manufacturer and is delivered to the customer along with the manufactured part. The...
US20170239298 CARDIAC PROGENITOR CELLS AND METHODS OF USE THEREFOR  
Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (CPCs) and/or progeny cells thereof that are...
9737493 Compositions and methods for modulating DNMT1 inhibitor activity  
Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising...
US20170224839 NANOPARTICLES FOR DRUG DELIVERY  
The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be...
US20170216285 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY  
Compounds, including quinoxaline derivatives of Formula (I), for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors...
9717733 Edible plant-derived microvesicle compositions including conjugated therapeutic agents and methods for using the same  
A composition is provided that includes a microvesicle derived from an edible plant and a therapeutic agent conjugated to the microvesicle. The therapeutic agent can be chemically-linked to a...
US20170197078 Neuromuscular Stimulation System and Method  
Provided are systems and methods employing wide pulse width, high frequency, neuromuscular electrical stimulation (“WPHF-NMES”) for the rehabilitation, treatment or recovery of a subject afflicted...