Patents and Patent Applications from University of Louisville


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US20180009764 METHOD FOR TREATING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS WITH IODO PYRIMIDINE DERIVATIVES  
Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula I: wherein A is selected from the group consisting of aromatic or...
9863002 Genetic determinants of prostate cancer risk  
Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their...
9852267 System and method for personalized dosing of pharmacologic agents  
A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective...
9849193 Nanoparticles for drug delivery  
The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial...
US20170360476 TROCAR FOR IMPROVED FLUID PRESSURE MANAGEMENT DURING ENDOSCOPIC SURGERY  
A trocar for arthroscopy and other endoscopic surgeries is provided, including a diaphragm seal, in which the assembly as a whole provides adequate insufflation of the body compartment during a...
9844514 Methods for treating an established myocardial infarction  
This application discloses methods for treating an established myocardial infarction, including treatment with an epicardial construct containing stromal vascular fraction (SVF) from adipose...
US20170348017 OPEN LOOP POLYPECTOMY SYSTEM  
Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a...
US20170321329 Solar Hydrogen Production from Ambient Water Vapor Electrolysis  
Hydrogen gas as a power source is obtained from gaseous water, including seawater vapor existing abundantly at near-surface levels of the oceans or humid air over land. An integrated system of...
US20170292161 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS USING MICRO RNAs  
Methods of detecting or predicting the presence of colorectal neoplasia are described based on the amounts of particular miRNAs in plasma.
9770587 Neuromuscular stimulation system and method  
Provided are systems and methods employing wide pulse width, high frequency, neuromuscular electrical stimulation (“WPHF-NMES”) for the rehabilitation, treatment or recovery of a subject afflicted...
US20170253758 CORE-SHELL NANOSTRUCTURES AND RELATED INKS, FILMS AND METHODS  
Copper inks are provided that include a plurality of core-shell nanostructures, with each nanostructure including a copper core and a barrier metal shell, a diameter of less than about 500 nm, and...
9755023 Photoelectrochemical cell including Ga(Sbx)N1-x semiconductor electrode  
The composition of matter comprising Ga(Sbx)N1−x where x=0.01 to 0.06 is characterized by a band gap between 2.4 and 1.7 eV. A semiconductor device includes a semiconductor layer of that...
9751950 Methods of reducing skeletal muscle loss using an antibody against Fn14  
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.
US20170250030 METHODS FOR FORMING A PEROVSKITE SOLAR CELL  
A perovskite thin film and method of forming a perovskite thin film are provided. The perovskite thin film includes a substrate, a hole blocking/electron transport layer, and a sintered perovskite...
US20170246809 QUALITY CERTIFICATION METHOD FOR AN ADDITIVE MANUFACTURING PROCESS  
In a quality certification method, a digital, three-dimensional Quality Certificate (3DQC) is created by the manufacturer and is delivered to the customer along with the manufactured part. The...
US20170239298 CARDIAC PROGENITOR CELLS AND METHODS OF USE THEREFOR  
Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (CPCs) and/or progeny cells thereof that are...
9737493 Compositions and methods for modulating DNMT1 inhibitor activity  
Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising...
US20170224839 NANOPARTICLES FOR DRUG DELIVERY  
The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be...
US20170216285 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY  
Compounds, including quinoxaline derivatives of Formula (I), for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors...
9717733 Edible plant-derived microvesicle compositions including conjugated therapeutic agents and methods for using the same  
A composition is provided that includes a microvesicle derived from an edible plant and a therapeutic agent conjugated to the microvesicle. The therapeutic agent can be chemically-linked to a...
US20170197078 Neuromuscular Stimulation System and Method  
Provided are systems and methods employing wide pulse width, high frequency, neuromuscular electrical stimulation (“WPHF-NMES”) for the rehabilitation, treatment or recovery of a subject afflicted...
9693693 Non-contact and passive measurement of arterial pulse through thermal IR imaging, and analysis of thermal IR imagery  
A non-contact, passive method for measurement of arterial pulse from areas such as the major superficial arteries of the body through analysis of thermal IR images acquired by passive thermal IR...
US20170184221 Bilayer Microvalve Arrays for Pneumatic and Fluidic Applications  
A strained bilayer film with reinforcing members is used to open and close gas flow outlets in a microvalve array. The bottom layer of the bilayer film is compressive and the top layer is tensile....
9683009 Bone-selective osteogenic oxysterol-bone targeting agents  
Compounds and compositions for the treatment of bone disorders are presented.
US20170166557 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
9678062 Methods and compositions for expanding cells and improving engraftment  
Methods of expanding FCs or stem cells are provided herein, as are methods of screening for compounds that increase expression of DOCK2 or decrease expression of Arhgap18, either of which improves...
US20170157389 PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION  
An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion...
9662265 Systems and methods for improving sensory eye dominance, binocular imbalance, and/or stereopsis in a subject  
The present invention relates to systems and methods for providing a Push-Pull perceptual learning technique to a subject demonstrating sensory eye dominance (SED), amblyopia, poor stereopsis, and...
US20170137892 EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER  
The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived...
US20170128496 METHODS AND COMPOSITIONS TO SUPPORT TRANSPLANTED TISSUE INTEGRATION AND INOSCULATION WITH ADIPOSE STROMAL CELLS  
The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular,...
9638695 Noninvasive detection of lung cancer using exhaled breath  
A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic...
9630162 Reactor and method for production of nanostructures  
A reactor and method for production of nanostructures, including metal oxide nanowires or nanoparticles, are provided. The reactor includes a regulated metal powder delivery system in...
9629615 Combined B-mode / tissue doppler approach for improved cardiac motion estimation in echocardiographic images  
A method for cardiac motion estimation includes: receiving a set of echocardiographic images of a heart, the echocardiographic images including B-mode ultrasonic images and Tissue Doppler Imaging...
US20170108499 PROGENITOR CELLS AND METHODS FOR PREPARING AND USING THE SAME  
Provided are methods for isolating subpopulations of stem cells. In some embodiments, the presently disclosed methods include selecting subsets of cells that are positive for CD34 or Sca-1, are...
US20170097352 IMMUNOGLOBULIN-BOUND EXTRACELLULAR VESICLES AND USES THEREOF  
Provided are methods of isolating IgG-bound (e.g., IgG-bound or protein G-recognized IgG-bound) extracellular vesicles from a sample containing a biological fluid from a subject, where the IgG...
US20170095562 ANTI-NUCLEOLIN AGENT-CONJUGATED NANOPARTICLES  
A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition...
US20170089645 Heat Pipe Augmented Passive Solar Heating System  
A heat pipe augmented passive solar space heating system modulates the temperature inside a building structure, particular during heating seasons when the ambient temperature is below levels...
US20170067057 Compositions and Methods for Treating Cancer, Inhibiting Cell Proliferation, and Inducing Cell Death  
Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a...
9588128 Peptide biomarkers of cardiovascular disease  
The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a...
US20170056432 CANCER THERAPY USING BETA GLUCAN AND ANTIBODIES  
The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal...
US20170056138 METHODS FOR FABRICATING DENTAL RESTORATIONS  
A method of fabricating a dental restoration is provided that includes the initial step of providing a powder of a dental material. An amount of a binder is then selectively deposited onto the...
9580393 6-substituted quinazolinone inhibitors  
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
US20170035700 COATED EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS AND METHODS FOR USING THE SAME  
Compositions are provided that comprise a microvesicle derived from an edible plant. The microvesicles are coated with a plasma membrane derived from a targeting cell and can further be utilized...
9561215 BAX-activating cancer therapeutics  
The pro-apoptotic Bcl-2 protein Bax initiates apoptosis in almost all apoptotic paradigms. Agents facilitating disruptive Bax insertion into mitochondrial membranes have potential as cancer...
US20170032520 COMPUTER AIDED DIAGNOSTIC SYSTEM FOR MAPPING OF BRAIN IMAGES  
Systems, methods, and computer program products for classifying a brain are disclosed. An embodiment method includes processing image data to generate segmented image data of a brain cortex. The...
US20170030892 NONINVASIVE DETECTION OF CANCER ORIGINATING IN TISSUE OUTSIDE OF THE LUNG USING EXHALED BREATH  
Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or...
9555054 Compositions and methods for reducing oxidative damage  
Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about...
US20170015712 COMPOSITIONS AND METHODS FOR TREATING, INCLUDING PREVENTING, PARVOVIRUS INFECTIONS AND RELATED DISEASES  
Some embodiments of the invention include inventive polypeptides (e.g., mutant VP2 proteins) and virus-like particles made from the inventive polypeptides. Other embodiments of the invention...
US20170000825 HUMAN FACILITATING CELLS  
The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.
9522187 Cancer therapy using beta glucan and antibodies  
The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal...