Patents and Patent Applications from University of Kentucky


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US20170349899 FUNGAL CHROMOSOME-END KNOCKOFF STRATEGY  
Non-toxigenic fungal strains, and methods of making and use thereof, are provided and have utility as endophytes in forage crops, and as strains that can outcompete toxigenic strains in forage and...
9835621 Process for detection of alzheimer's disease from a serum sample  
Disclosed is a method of detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI). Also disclosed is...
US20170343530 LIPID BILAYER-INTEGRATED SPP1 CONNECTOR PROTEIN NANOPORE AND SPP1 CONNECTOR PROTEIN VARIANTS FOR USE AS LIPID BILAYER-INTEGRATED NANOPORE  
A conductive channel-containing membrane includes a membrane layer, and a SPP1 connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which...
US20170335330 ANTISENSE OLIGONUCLEOTIDE MODULATORS OF SEROTONIN RECEPTOR 2C AND USES THEREOF  
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders...
9821037 Compounds and method of use as anti-infection compounds and therapeutic agents to regulate cholesterol metabolism  
A compound is provided which comprises at least a portion of an amino acid linker-domain from squalene synthase. In alternative forms, the compound can include the amino-acid linker-domain from...
US20170331111 FLUORINATED COAL DERIVED CARBONS AND ELECTRODES FOR USE IN BATTERY SYSTEMS AND SIMILAR  
An electrode including fluorinated and surface defluorinated coal is described, as well as methods of producing such and employing such within an electrical system. The coal in the electrodes is...
US20170304227 Vesicular Monoamine Transporter-2 Ligands and Their Use in the Treatment of Psychostimulant Abuse  
The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal...
9790233 Compositions and methods of modulating 15-PGDH activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
US20170283270 NOVEL GRAPHENE-LIKE Si2BN MATERIAL AND METHOD OF MAKING THEREOF  
This application relates to monolayers of Si2BN or C2BN, arranged in a graphiticized hexagonal arrangement. Each Si/C atom has a Si/C, B, and N nearest neighbor, while each B (N) has two Si/C's...
US20170281751 EQUINE DISEASE MODEL FOR HERPESVIRUS NEUROLOGIC DISEASE AND USES THEREOF  
The present invention relates to an in vivo equine disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific CTL...
9770033 Compositions and methods for pest control management  
Disclosed are genetically modified nudiviruses capable of being sexually transmitted by an insect useful for controlling pest populations. The genetically modified nudiviruses are capable of...
9755023 Photoelectrochemical cell including Ga(Sbx)N1-x semiconductor electrode  
The composition of matter comprising Ga(Sbx)N1−x where x=0.01 to 0.06 is characterized by a band gap between 2.4 and 1.7 eV. A semiconductor device includes a semiconductor layer of that...
US20170248610 METHOD OF PREDICTING OBESITY  
The presently disclosed subject matter relates to a method for predicting increased risk of obesity on a non-obese subject. More particularly, the presently disclosed subject matter relates to a...
US20170232380 METHOD OF DEVELOPMENT AND USE OF CATALYST-FUNCTIONALIZED CATALYTIC PARTICLES TO INCREASE THE MASS TRANSFER RATE OF SOLVENTS USED IN ACID GAS CLEANUP  
The present invention relates to methods for improving carbon capture using entrained catalytic-particles within an amine solvent. The particles are functionalized and appended with a CO2...
US20170226072 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds  
The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
US20170224698 USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS  
The present invention provides compounds of the formula (I) wherein:X1, X2 and X3 are heteroatoms;R4, R5, R6, R7, R3, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and...
US20170224632 Microparticle Enabled Delivery Structures, Methods of Preparing and Using Same  
The disclosed subject matter relates to the delivery of hydroxyl-containing compounds as microparticles for a variety of pharmaceutical, biomedical, cosmetics and personal care applications. This...
9724337 AG-205 for the treatment of breast cancer  
Compositions, methods, and combination therapies for the treatment of cancers, including lymphomas, leukemias, melanomas, lung cancer, and metastatic disease, are provided. Specifically,...
US20170222151 WATER PROCESSABLE N-TYPE ORGANIC SEMICONDUCTOR  
The present invention concerns a water-processable n-type semiconductor comprised of polyvinylpyrrolidone (PVP), carbon nanotubes (CNTs) and poly(ethyleneimine) (PEI). The semiconductors are...
US20170216763 CO2 MASS TRANSFER ENHANCEMENT OF AQUEOUS AMINE SOLVENTS BY PARTICLE ADDITIVES  
The present invention relates to methods for improving carbon capture by providing particles within an amine solvent. The particles provide for increased turbulence at the interface between the...
9718799 3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer  
Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the treatment or inhibition of prostate...
US20170214096 LOW TEMPERATURE LIQUID METAL BATTERIES FOR ENERGY STORAGE APPLICATIONS  
The present invention relates to a molten metal battery of liquid bismuth and liquid tin electrodes and a eutectic electrolyte. The electrodes may be coaxial and coplanar. The eutectic electrolyte...
9707235 Protection of cells from degeneration and treatment of geographic atrophy  
Therapeutic uses P2X7 inhibition and inhibition of IRAK1 and/or IRAK4, methods protecting a cell, and screening methods for identifying inhibitors are described herein.
US20170175122 RNA-BASED COMPOSITIONS AND ADJUVANTS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT  
The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand...
US20170174639 EIS INHIBITORS  
Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further...
US20170173108 Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation  
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS...
US20170165241 COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
9678583 2D and 3D pointing device based on a passive lights detection operation method using one camera  
Systems for surface-free pointing and/or command input include a computing device operably linked to an imaging device. The imaging device can be any suitable video recording device including a...
9675928 Method of inhibiting nitrosation of an aqueous amine solution used in a process of removing carbon dioxide from a flue gas  
A method is provided for inhibiting nitrosation of an aqueous amine solution used in a process of removing carbon dioxide from a flue gas. That method includes a step of adding an effective amount...
9670066 Carbon particles  
A composition generally includes carbon particles. The particles are prepared by dissolving a carbohydrate-based precursor in water to form a precursor solution and placing the precursor solution...
US20170155164 LIQUID PHENOTHIAZINE CATHOLYTES FOR NON-AQUEOUS REDOX FLOW BATTERIES  
Highly soluble, liquid phenothiazines containing methoxy-terminated ether and oligoether substituents are disclosed with high diffusion coefficients and robust performance in electrochemical...
9649301 Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors  
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of...
9647094 Method of manufacturing a semiconductor heteroepitaxy structure  
A method of manufacturing a semiconductor structure includes the steps of depositing a layer of semiconductor oxide on a base semiconductor layer, scavenging oxygen from the layer of semiconductor...
9642908 Equine disease model for herpesvirus neurologic disease and uses thereof  
Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of...
9642845 Method for alleviating side effects of retinoic acid therapy and/or improving efficacy without interfering with efficacy  
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a...
US20170098818 SOLVENT-FREE DRY POWDER-COATING METHOD FOR ELECTRODE FABRICATION  
Electrostatic dry powder spray processes are disclosed for making battery electrodes. The electrodes made by dry powder coating processes are conventional lithium ion battery electrodes and...
US20170089906 BIOMARKERS FOR OVARIAN CANCER  
The present invention provides protein-based biomarkers and biomarker combinations that am useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention...
9586992 Amidated dopamine neuron stimulating peptides for CNS dopaminergic upregulation  
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS...
9586946 Selective immunoproteasome inhibitors with non-peptide scaffolds  
Compounds useful for inhibiting the immunoproteasome have the formula of Methods and compounds for inhibiting the immunoproteasome, particularly, immunoproteasome inhibitors with non-peptide...
US20170055512 Microfabricated Surfaces for The Physical Capture of Insects  
Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the...
US20170051199 PROPPANT FOR USE IN HYDRAULIC FRACTURING TO STIMULATE A WELL  
A proppant for use in hydraulic fracturing to stimulate a well is provided. The proppant is fly ash particles having a mean particle size (d50) of between 45 μm and 150 μm and a size distribution...
9567585 Antisense oligonucleotide modulators of serotonin receptor 2C and uses thereof  
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders...
9566341 Compounds including Cox inhibitor moiety and enhanced delivery of active drugs using same  
The presently-disclosed subject matter includes compounds including a cyclooxygenase enzyme inhibitor moiety and a moiety derived from a drug of interest. In some embodiments, the drug of interest...
9550753 Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors  
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
9540327 Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors  
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
9534237 Sesquiterpene synthase gene and protein  
The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene...
9533883 Apparatus and method for harvesting carbon nanotube arrays  
An apparatus is provided for harvesting a carbon nanotube array from a substrate. The apparatus includes a peeler that peels the carbon nanotube array from the substrate and a support that...
US20160367945 GREEN SYNTHESIS NANOCOMPOSITE MEMBRANES  
A nanocomposite membrane includes a macroporous polymer membrane having a plurality of pores. A plurality of metal nanoparticles are synthesized and immobilized within those plurality of pores....
US20160361683 METHOD OF INCREASING MASS TRANSFER RATE OF ACID GAS SCRUBBING SOLVENTS  
A method of increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are also disclosed.
9504957 Flue gas desulfurization apparatus  
An apparatus is provided for removing sulfur oxides from a flue gas stream. That apparatus includes an absorber tower having an upper section and a lower section. A packed bed unit is provided in...