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US20120122943 |
Melampomagnolide B Derivatives as Antileukemic and Cytotoxic Agents
Melampomagnolide B is disclosed as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was prepared to elucidate its mechanism of action. Prodrugs of...
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US20120118308 |
ALTERATION OF TOBACCO ALKALOID CONTENT THROUGH MODIFICATION OF SPECIFIC CYTOCHROME P450 GENES
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated p...
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US20120117933 |
ALTERATION OF TOBACCO ALKALOID CONTENT THROUGH MODIFICATION OF SPECIFIC CYTOCHROME P450 GENES
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated p...
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8178678 |
Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic...
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US20120113229 |
Rotate and Hold and Scan (RAHAS) Structured Light Illumination Pattern Encoding and Decoding
A unique computer-implemented process, system, and computer-readable storage medium having stored thereon, executable program code and instructions for 3-dimentional (3-D) image acquisition of a...
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8167955 |
Carbon fiber reinforced carbon foams for repair and reconstruction of bone defects
The present invention relates to a tissue scaffold and a method of preparing a tissue scaffold for implantation. The tissue scaffold includes a body having a graphite foam core. At least a first...
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US20120092463 |
Dual-frequency Phase Multiplexing (DFPM) and Period Coded Phase Measuring (PCPM) Pattern Strategies in 3-D Structured Light Systems, and Lookup Table (LUT) Based Data Processing
A computer-implemented process, system, and computer-readable storage medium having stored thereon, program code and instructions for 3-D triangulation-based image acquisition of a contoured...
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8138309 |
Modified rubisco large subunit n-methyltransferase useful for targeting molecules to the active-site vicinity of ribulose-1,5-bisphosphate
The present invention generally relates to a modified Rubisco large subunit εN-Methyltransferase (Rubisco LSMT, or RLSMT). The present invention also relates to a modified RLSMT-carbonic anhydrase ...
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8137676 |
Genetically engineered equine influenza virus and uses thereof
The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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US20120064010 |
CCR3 and its Ligands Are Therapeutic and Diagnostic Targets for Neovascular Age-Related Macular Degeneration
The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither...
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8124851 |
Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated p...
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8124652 |
Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) wherein:X1, X2 and X3 are heteroatoms;R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optio...
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8115059 |
Gene expression modulation system for use in plants and method for modulating gene expression in plants
An EcR-based gene expression modulation system for use in plants includes an EcR gene expression cassette, a modified RXR gene expression cassette, and a gene-of-interest expression cassette, which...
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8114390 |
Method for treating hair growth disorders, such as female pattern alopecia, and compositions useful therefore
The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid...
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8110184 |
Ex vivo and in vivo methods and related compositions for generating hematopoietic stem cell populations
Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells...
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8106260 |
Chimeric isoprenoid synthases and uses thereof
Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby...
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8101779 |
Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
Methods for the enantioselective synthesis of (+) and (−) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene involve converting (+) or (−) 1-m...
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8101354 |
Method for screening for a tobiano coat color genotype
A method for screening for a Tobiano genotype includes obtaining a nucleic acid from an equine animal, and analyzing the nucleic acid for the presence of an inversion in a chromosome ECA3q which is...
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8067432 |
Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors
A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes preparing a solution of the...
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8066883 |
Removing aluminum from solution using chelating compounds and immobilized tethered chelators
Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.
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US20110288844 |
Modeling of mPGES-1 three-dimensional structures: applications in drug design and discovery
This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by...
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8053633 |
Fungal desaturases and related methods
The presently-disclosed subject matter provides isolated nucleic acid and amino acid sequences encoding mushroom desaturase polypeptides that are active with both palmitic and stearic acid, as well...
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US20110268723 |
CCR3 Inhibition for Ocular Angiogenesis and Macular Degeneration
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin...
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US20110263518 |
D-Tagatose-Based Compositions and Methods for Preventing and Treating Atherosclerosis, Metabolic Syndrome, and Symptoms Thereof
Pharmaceutical compositions including D-tagatose along with a stilbene or stilbenoid component, or a salt or derivative thereof. Methods of prophylaxis and therapy by administering to a mammal a...
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8042405 |
Method and apparatus for characterizing microscale formability of thin sheet materials
A method of predicting sheet formability at a microscale level includes the steps of providing a grid pattern on a test sheet, bulging the test sheet to a hemispherical shape until a crack is...
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8030358 |
Methods and pharmaceutical compositions for decorporation of radioactive compounds
A composition for removing a radioactive element or compound such as systemic transuranic compounds, from mammals comprises a pharmaceutical carrier and a decorporation agent comprising ester and...
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8017835 |
Transformed plants accumulating terpenes
The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene...
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8012735 |
Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ...
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8008092 |
CCR3 inhibition for ocular angiogenesis and macular degeneration
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin...
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US20110195030 |
NANOPARTICLE COMPOSITIONS COMPRISING LIQUID OIL CORES
Nanocapsule and nanoemulsion particle compositions having improved physical and pharmacological properties are provided. The nanocapsule or nanoemulsion particle composition can comprise a...
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7985568 |
Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use
This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are...
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US20110178025 |
Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (...
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US20110174322 |
ALTERATION OF TOBACCO ALKALOID CONTENT THROUGH MODIFICATION OF SPECIFIC CYTOCHROME P450 GENES
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated p...
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7982041 |
Camptothecin analogs and methods of preparation thereof
A compound having the formula in racemic form, enantiomerically enriched form or enantiomerically pure form, and pharmaceutically acceptable salts thereof.
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US20110166208 |
Nucleotide and Amino Acid Sequences for Calmodulin Protein Methyltransferase
The present invention provides nucleic acid and amino acid sequences for calmodulin protein methyltransferase. The present invention also provides diagnostic tools and methods of using the present...
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US20110166177 |
BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
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US20110160694 |
Nanotubes as Mitochondrial Uncouplers
A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A...
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US20110160561 |
SYSTEM, DEVICE, AND METHOD FOR DETERMINATION OF INTRAOCULAR PRESSURE
A system for determination of intraocular pressure includes: an intraocular pressure sensor; a light source illuminating the sensor with one or more wavelengths of light; and a detector that...
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7964223 |
Berry preparations and extracts
A method for deriving compositions having antioxidant and anti-inflammatory activity from berries is provided. The method results in a berry extract compositions having stable anthocyanin content....
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7963398 |
Method for hydraulically separating carbon and classifying coal combustion ash
A method for selective separation of particles from a particle-containing material includes preparing a slurry of the particle-containing material and a dispersant, passing the slurry through a...
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US20110142938 |
Nanotubes as Mitochondrial Uncouplers
A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A...
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7954595 |
Lightweight inflatable borehole receiver unit for seismic testing
A borehole receiver for seismic testing has a support frame and an inflatable membrane configured to form a single, compact unit. The inflatable membrane has at least one sensor, such as an...
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US20110118299 |
TREATMENT OF MCI AND ALZHEIMER'S DISEASE
The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g.,...
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US20110112131 |
Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management
The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and ketamine or norketamine which have been combined to form a...
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US20110112130 |
Opioid-Nornicotine Codrugs Combinations for Pain Management
The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical...
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US20110105556 |
TRIS-QUARTERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a...
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US20110104724 |
BIOMARKERS OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE
A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and...
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US20110097390 |
Ultra-Small RNAs as Toll-Like Receptor-3 Antagonists
Provided are methods and compositions for the treatment or prevention of macular degeneration or other diseases or disorders associated with activation of TLR3. Administration of double stranded...
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7932326 |
Chelating compounds and immobilized tethered chelators
Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
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7928284 |
Methods and animal model for analyzing age-related macular degeneration
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and...
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