Patents and Patent Applications from University of Kentucky


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9895354 Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities  
The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers...
9895324 Halogenated diarylacetylenes and methods of treating cancer  
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon...
US20180044327 COMPOSITIONS AND METHODS FOR TREATING RETINAL DEGRADATION  
The present disclosure relates to compounds, compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by...
9879240 High activity mutants of cocaine esterase for cocaine hydrolysis  
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (−)-cocaine, as compared to CocE mutants in the prior art, including CocE mutant...
9879043 Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase  
The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine...
US20180026297 1,9,10-SUBSTITUTED PHENATHIAZINE DERIVATIVES WITH STRAINED RADICAL CATIONS AND USE THEREOF  
Compounds for use in a rechargeable battery are provided, including a compound according to the formula: wherein R1 and R9 are independently selected from the group consisting of H, alkyl, aryl,...
US20180020962 COMPACT LOW-COST FIBERLESS DIFFUSE SPECKLE CONTRAST FLOW-OXIMETER  
A low-cost compact fiberless diffuse speckle contrast flowmeter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (CCD) or complementary metal oxide...
9873670 Arylquinoline and analog compounds and use thereof to treat cancer  
The subject technology relates to arylquinoline compounds and their use for treating cancer or cancer metastasis. The compounds of the subject technology promote cells to secrete a pro-apoptotic...
US20180019470 Polyborosiloxane Binders  
Electrodes for rechargeable batteries that include silicon and a binder are provided. Binders for use with silicon electrodes are provided, including polysiloxane binders that can be prepared...
US20180019122 DESIGN AND SYNTHESIS OF METAL OXIDE SURFACES AND INTERFACES WITH CRYSTALLOGRAPHIC CONTROL USING SOLID-LIQUID-VAPOR ETCHING AND VAPOR-LIQUID-SOLID GROWTH  
The present invention provides integrated nanostructures comprising a single-crystalline matrix of a material A containing aligned, single-crystalline nanowires of a material B, with well-defined...
US20180011990 METHOD AND SYSTEM FOR IDENTIFICATION OF METABOLITES  
A method and system is provided for mass spectrometry for identification of a specific elemental formula for an unknown compound which includes but is not limited to a metabolite. The method...
US20180009741 BISHYDRAZONE-BASED ANTIFUNGAL AGENTS  
Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject...
9861319 Noncontact three-dimensional diffuse optical imaging of deep tissue blood flow distribution  
The present invention provides for three-dimensional reflectance diffuse optical imaging of deep tissue blood flow distribution that removes the need for probe-tissue contact, thereby allowing for...
US20180006336 RECHARGEABLE BATTERIES INCLUDING HIGH-VOLTAGE CATHODE AND REDOX SHUTTLE CONFERRING OVERCHARGE PROTECTION  
Compounds for use as photoredox catalysts and as redox shuttles in a rechargeable battery having a high-voltage cathode providing overcharge protection capabilities are provided, including a...
9859513 Integrated multi-terminal devices consisting of carbon nanotube, few-layer graphene nanogaps and few-layer graphene nanoribbons having crystallographically controlled interfaces  
The present invention relates to atomically-thin channel materials with crystallographically uniform interfaces to atomically-thin commensurate graphene electrodes and/or nanoribbons separated by...
US20170355942 CYCLIC PHOTOBIOREACTOR AND METHOD FOR BIOFILM CONTROL  
The invention herein describes a novel photobioreactor (PBR) system for culturing algae. The PBR system utilizes vertical transparent tubes that can be cyclically filled with an algae culture. The...
US20170349899 FUNGAL CHROMOSOME-END KNOCKOFF STRATEGY  
Non-toxigenic fungal strains, and methods of making and use thereof, are provided and have utility as endophytes in forage crops, and as strains that can outcompete toxigenic strains in forage and...
9835621 Process for detection of alzheimer's disease from a serum sample  
Disclosed is a method of detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI). Also disclosed is...
US20170343530 LIPID BILAYER-INTEGRATED SPP1 CONNECTOR PROTEIN NANOPORE AND SPP1 CONNECTOR PROTEIN VARIANTS FOR USE AS LIPID BILAYER-INTEGRATED NANOPORE  
A conductive channel-containing membrane includes a membrane layer, and a SPP1 connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which...
US20170335330 ANTISENSE OLIGONUCLEOTIDE MODULATORS OF SEROTONIN RECEPTOR 2C AND USES THEREOF  
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders...
9821037 Compounds and method of use as anti-infection compounds and therapeutic agents to regulate cholesterol metabolism  
A compound is provided which comprises at least a portion of an amino acid linker-domain from squalene synthase. In alternative forms, the compound can include the amino-acid linker-domain from...
US20170331111 FLUORINATED COAL DERIVED CARBONS AND ELECTRODES FOR USE IN BATTERY SYSTEMS AND SIMILAR  
An electrode including fluorinated and surface defluorinated coal is described, as well as methods of producing such and employing such within an electrical system. The coal in the electrodes is...
US20170304227 Vesicular Monoamine Transporter-2 Ligands and Their Use in the Treatment of Psychostimulant Abuse  
The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal...
9790233 Compositions and methods of modulating 15-PGDH activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
US20170283270 NOVEL GRAPHENE-LIKE Si2BN MATERIAL AND METHOD OF MAKING THEREOF  
This application relates to monolayers of Si2BN or C2BN, arranged in a graphiticized hexagonal arrangement. Each Si/C atom has a Si/C, B, and N nearest neighbor, while each B (N) has two Si/C's...
US20170281751 EQUINE DISEASE MODEL FOR HERPESVIRUS NEUROLOGIC DISEASE AND USES THEREOF  
The present invention relates to an in vivo equine disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific CTL...
9770033 Compositions and methods for pest control management  
Disclosed are genetically modified nudiviruses capable of being sexually transmitted by an insect useful for controlling pest populations. The genetically modified nudiviruses are capable of...
9755023 Photoelectrochemical cell including Ga(Sbx)N1-x semiconductor electrode  
The composition of matter comprising Ga(Sbx)N1−x where x=0.01 to 0.06 is characterized by a band gap between 2.4 and 1.7 eV. A semiconductor device includes a semiconductor layer of that...
US20170248610 METHOD OF PREDICTING OBESITY  
The presently disclosed subject matter relates to a method for predicting increased risk of obesity on a non-obese subject. More particularly, the presently disclosed subject matter relates to a...
US20170232380 METHOD OF DEVELOPMENT AND USE OF CATALYST-FUNCTIONALIZED CATALYTIC PARTICLES TO INCREASE THE MASS TRANSFER RATE OF SOLVENTS USED IN ACID GAS CLEANUP  
The present invention relates to methods for improving carbon capture using entrained catalytic-particles within an amine solvent. The particles are functionalized and appended with a CO2...
US20170226072 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds  
The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.
US20170224698 USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS  
The present invention provides compounds of the formula (I) wherein:X1, X2 and X3 are heteroatoms;R4, R5, R6, R7, R3, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and...
US20170224632 Microparticle Enabled Delivery Structures, Methods of Preparing and Using Same  
The disclosed subject matter relates to the delivery of hydroxyl-containing compounds as microparticles for a variety of pharmaceutical, biomedical, cosmetics and personal care applications. This...
9724337 AG-205 for the treatment of breast cancer  
Compositions, methods, and combination therapies for the treatment of cancers, including lymphomas, leukemias, melanomas, lung cancer, and metastatic disease, are provided. Specifically,...
US20170222151 WATER PROCESSABLE N-TYPE ORGANIC SEMICONDUCTOR  
The present invention concerns a water-processable n-type semiconductor comprised of polyvinylpyrrolidone (PVP), carbon nanotubes (CNTs) and poly(ethyleneimine) (PEI). The semiconductors are...
US20170216763 CO2 MASS TRANSFER ENHANCEMENT OF AQUEOUS AMINE SOLVENTS BY PARTICLE ADDITIVES  
The present invention relates to methods for improving carbon capture by providing particles within an amine solvent. The particles provide for increased turbulence at the interface between the...
9718799 3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer  
Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the treatment or inhibition of prostate...
US20170214096 LOW TEMPERATURE LIQUID METAL BATTERIES FOR ENERGY STORAGE APPLICATIONS  
The present invention relates to a molten metal battery of liquid bismuth and liquid tin electrodes and a eutectic electrolyte. The electrodes may be coaxial and coplanar. The eutectic electrolyte...
9707235 Protection of cells from degeneration and treatment of geographic atrophy  
Therapeutic uses P2X7 inhibition and inhibition of IRAK1 and/or IRAK4, methods protecting a cell, and screening methods for identifying inhibitors are described herein.
US20170175122 RNA-BASED COMPOSITIONS AND ADJUVANTS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT  
The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand...
US20170174639 EIS INHIBITORS  
Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further...
US20170173108 Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation  
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS...
US20170165241 COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
9678583 2D and 3D pointing device based on a passive lights detection operation method using one camera  
Systems for surface-free pointing and/or command input include a computing device operably linked to an imaging device. The imaging device can be any suitable video recording device including a...
9675928 Method of inhibiting nitrosation of an aqueous amine solution used in a process of removing carbon dioxide from a flue gas  
A method is provided for inhibiting nitrosation of an aqueous amine solution used in a process of removing carbon dioxide from a flue gas. That method includes a step of adding an effective amount...
9670066 Carbon particles  
A composition generally includes carbon particles. The particles are prepared by dissolving a carbohydrate-based precursor in water to form a precursor solution and placing the precursor solution...
US20170155164 LIQUID PHENOTHIAZINE CATHOLYTES FOR NON-AQUEOUS REDOX FLOW BATTERIES  
Highly soluble, liquid phenothiazines containing methoxy-terminated ether and oligoether substituents are disclosed with high diffusion coefficients and robust performance in electrochemical...
9649301 Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors  
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of...
9647094 Method of manufacturing a semiconductor heteroepitaxy structure  
A method of manufacturing a semiconductor structure includes the steps of depositing a layer of semiconductor oxide on a base semiconductor layer, scavenging oxygen from the layer of semiconductor...
9642908 Equine disease model for herpesvirus neurologic disease and uses thereof  
Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of...