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Patents and Patent Applications from University of Kansas


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8897640 Digital subcarrier optical network utilizing digital subcarrier cross-connects with increased energy efficiency  
The present invention provides reduced power dissipation and other benefits at the optical transport network layer by utilizing a digital subcarrier optical network comprising multiple digital...
8895048 Templated islet cells and small islet cell clusters for diabetes treatment  
Substrates and devices for culturing cells are disclosed, along with methods of using the same. The substrates and devices include top surfaces with one or more divots disposed therein. Each divot...
US20140343305 PROCESS FOR PRODUCING BOTH BIOBASED SUCCINIC ACID AND 2,5-FURANDICARBOXYLIC ACID  
A process is provided for carrying out an oxidation on a feed including levulinic acid and/or a levulinic acid oxidation precursor to succinic acid, one or more furanic oxidation precursors of...
8891850 System and methods for digital evaluation of cellblock preparations  
Digital evaluation of cellblock preparations to determine the type and extent of disease in order to identify the best approach for treatment without the need for additional testing or sampling.
8889631 Disruptors of early/recycling endosomes  
A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first...
US20140335555 AUTOMATED VITRIFICATION DEVICE  
The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require...
8878157 Semiconductor-graphene hybrids formed using solution growth  
A novel method for fabrication of hybrid semiconductor-graphene nanostructures in large scale by floating graphene sheets on the surface of a solution is provided. Using this approach, crystalline...
US20140323438 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
8865708 Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase  
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are...
8841109 IGA1 protease polypeptide agents and uses thereof  
Polypeptide agents useful in the treatment of IgA1 deposition diseases and methods of using such polypeptide agents. Methods of screening for inhibitors of IgA1 proteases and agents that inhibit...
US20140274386 PEER-SCORED COMMUNICATION IN ONLINE ENVIRONMENTS  
Systems and methods for peer-scored dialogue are provided. Meaningful communications are fostered by enabling students or players of an online game to affect the score of other players by scoring...
US20140256922 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such...
US20140245844 SIMPLIFIED SPINE TESTING DEVICE  
A sample testing device includes a motor, a gear reducer, and an output shaft coupled for rotation by the motor via the gear reducer. The sample testing device further includes a first device...
8822734 Single solvent gas expanded hydroformylation process  
Allyl alcohol, particularly from biobased sources such as glycerol, is hydroformylated to products including 4-hydroxybutyraldehyde and 4-hydroxy-2-methylpropionaldehyde by forming a homogeneous...
US20140243333 SYNTHESIS OF FUNCTIONALIZED OCTAHYDRO-ISOQUINOLIN-1-ONE-8-CARBOXYLIC ESTERS AND ANALOGS, AND THERAPEUTIC METHODS  
A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with...
US20140238702 LOW PH CROSSLINKING OF POLYMERS  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
8809278 Cyclic tetrapeptides  
Cyclic tetrapeptides that are kappa opioid receptor (KOR) antagonists can be used in therapeutic applications for treating, inhibiting, and/or preventing drug addiction, drug use, or drug seeking...
US20140227225 HCV Helicase Inhibitors and Methods of Use Thereof  
The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention...
8802235 Drug and imaging agent delivery compositions and methods  
A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical...
8802109 Herpes simplex virus mutant ICP0  
A mutant herpesvirus that has a mutated gene that encodes a mutant infected cell protein 0 (ICP0) can be used in therapeutic methods as well as in diagnostics and research experiments. The encoded...
8801939 Ozonolysis reactions in liquid CO2 and CO2-expanded solvents  
A method for increasing ozone concentration in a liquid can include: providing a gas having ozone; introducing the ozone-containing gas into a liquid, wherein the liquid and ozone combination has a...
US20140221491 In Vivo Method for Treating, Inhibiting, and/or Prophylaxis of Cancer, such as Pancreatic Cancer  
An in vivo method of inhibiting tumor growth, specifically pancreatic cancer, includes administering to a subject in need thereof an effective amount of a compound, composition, and/or a...
US20140219997 Templated Islet Cells and Small Islet Cell Clusters for Diabetes Treatment  
A population of small reaggregated islets or clusters engineered from individual islet cells and having improved characteristics as compared to native isolated islets.
US20140209305 DELAYED GELLING AGENTS  
The disclosure is directed to polyelectrolyte complex nanoparticles that can be used to deliver agents deep into hydrocarbon reservoirs. Methods of making and using said polyelectrolyte complex...
US20140202693 NANOGELS FOR DELAYED GELATION  
The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for...
8785411 HIV DNA vaccine methods of use  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
US20140200678 BIOMATERIALS WITH MICROSPHERE GRADIENTS AND CORE AND SHELL MICROSPHERES  
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a...
US20140196894 FLUORESCENT TAGS FOR DETECTION OF SWELLABLE POLYMERS  
The invention is directed to stable crosslinked swellable fluorescently tagged polymeric microparticles, methods for making same, and their various uses. A particularly important use is as an...
8777157 Tethered hovering platform  
The design and refinement of a tethered hovering platform into a feasible working system is presented. To determine a starting point for the design, a detailed historical search was conducted to...
8765803 Rab7 GTPase inhibitors and related methods of treatment  
This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer,...
8765140 DNA vaccine compositions with HIV/SIV gene modifications  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
US20140163528 MANEUVERABLE NASOENTERIC FEEDING TUBE  
A maneuverable feeding tube system can include: a feeding tube having an internal lumen and distal opening; a maneuverable tube having a flexible distal end being located within the internal lumen...
US20140162912 SWELLABLE POLYMER WITH CATIONIC SITES  
The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising...
8747563 Method and apparatus for anti-fouling an anemometer  
An apparatus and method for adaptive materials arranged in a variety of orientations and with a wide range of attachment configurations to induce structural vibrations at extremely high...
US20140148915 GENERATING CK19-POSITIVE CELLS WITH HAIR-LIKE STRUCTURES FROM WHARTONS JELLY  
A method of differentiating cells into CK19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the scaffold,...
US20140144628 CROSSLINKING OF SWELLABLE POLYMER WITH PEI  
The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and...
8735391 Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods  
A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with...
8735154 Templated islet cells and small islet cell clusters for diabetes treatment  
A scaffold having islet cells or small islet cell clusters attached thereto in a multilayer, and a micro-mold having divots for culturing islets, wherein islet formation is influenced by the shape...
8734367 Method and apparatus for measuring non-nutritive suck pattern stability  
Method and apparatus are provided for generating an index associated with non-nutritive suck pattern stability. An example apparatus can include an STI generator configured to generate a plurality...
8728486 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such...
US20140135484 Metal Abstraction Peptide (MAP) Tag and Associated Methods  
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal...
US20140131043 SWELLABLE POLYMER WITH ANIONIC SITES  
The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable...
8715983 Hudrogel network comprising thermally gelling polysaccharide or protein gel encapsulating living cells  
The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living...
8709997 Prevention and treatment of osteoarthritis  
Subjects lacking Nfat1 display osteoarthritis in weight-bearing joints. Osteoarthritic changes associated with Nfat1 deficiency are characterized by articular cartilage degradation, articular...
US20140100260 Enalapril Compositions  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
8691736 Swellable polymer with cationic sites  
The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising...
8685966 GRP94 inhibitors  
The present disclosure provides a series of compounds which exhibit isoform selective inhibition of GRP94, a homologue of Hsp90 that is localized to the endoplasmic recticulum. Through GRP94...
US20140088144 INHIBITING MICROBIAL INFECTIONS  
A method of inhibiting a microbial infection can include: providing a compound of the invention or prodrugs or pharmaceutically acceptable salts thereof; and administering the compound to a subject...
US20140081050 SINGLE SOLVENT GAS EXPANDED HYDROFORMYLATION PROCESS  
Allyl alcohol, particularly from biobased sources such as glycerol, is hydroformylated to products including 4-hydroxybutyraldehyde and 4-hydroxy-2-methylpropionaldehyde by forming a homogeneous...
8673584 Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase  
A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal...