Patents and Patent Applications from University of Kansas


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US20170176450 SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN STABILIZERS  
A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a...
US20170166557 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
9677580 Radar energy absorbing deformable low drag vortex generator  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9676818 Toll-like receptor 2-agonistic lipopeptides, and method of making the same  
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These...
9675636 Micelle sequestering polymers  
A polymer composition for sequestering lipid-bile acid micelles in the gastrointestinal (GI) tract is provided. The polymer composition comprises a copolymer of a pH-sensitive monomer and one or...
9670247 Contraceptive agents  
The invention provides compounds of formula I, II, III, or IV: wherein R1 to R11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase α4 and are useful...
9663521 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170145043 DEPOLYMERIZATION OF LIGNIN USING METAL INCORPORATED MESOPOROUS SILICATE CATALYSTS  
Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid mesoporous silicate catalyst under...
US20170144965 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT  
A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective...
US20170137115 RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
US20170135683 SOLENOID OCCLUSION DEVICE  
The present disclosure relates to devices and methods for delivery of a ferrofluid to a targeted treatment site, such as delivery of a ferroadhesive to a pathological fistula to occlude the...
9644136 Low pH crosslinking of polymers  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
9642835 Modulators of GTPase and use in relevant treatment  
The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous (Rho) family of small GTPases, in...
US20170122973 SYSTEMS, METHODS, AND DEVICES FOR FLUID DATA SENSING  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
US20170121719 DEREPLICATION STRAIN OF ASPERGILLUS NIDULANS  
Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include A. nidulans. The deleted gene clusters are selected from the group of gene clusters...
9636419 Targeting multiple receptors on a cell surface for specific cell targeting  
A method of delivering a cargo agent into cytosol of a cell can include: providing the delivery system of one of the embodiments described herein having the first and second delivery platforms;...
US20170114053 HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF  
Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for...
US20170107497 IMPROVED RELIABILITY OF ASSAYS USING A MULTI-DIVOT PLATFORM AND MULTI-SOURCE, MULTI-CELL TYPE CLUSTERS  
Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and...
US20170100591 METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
9616119 Neuroattenuated herpes simplex virus  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
9611270 Inhibitors of CYP17A1  
Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting...
9601040 Flat-stock aerial vehicles and methods of use  
A flat-stock aerial vehicle includes a body having a plurality of flat-stock sheets connected to one another, at least one motor, and at least three aerodynamic propulsors driven by the at least...
9593095 Methods for the treatment of bacterial infections  
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule...
US20170067018 REPROGRAMMING OF HUMAN WHARTON'S JELLY CELLS TO PRODUCE HAIR CELLS  
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells...
US20170065978 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES  
A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly...
US20170065742 METHACRYLATED DEVITALIZED CARTILAGE AND DEVITALIZED CARTILAGE PARTICLES  
An implantable composition can include methacrylated solubilized devitalized cartilage (MeSDVC) with or without devitalized cartilage (DVC) particles. These compositions can be hydrogel...
US20170065540 METHODS AND COMPOSITIONS FOR TREATING INFECTION  
Provided herein are compositions and methods for treating or preventing infection.
9586923 Spray oxidation process for producing 2,5-furandicarboxylic acid from hydroxymethylfurfural  
A process is provided for carrying out an oxidation on a sprayable feed including a furanic substrate to be oxidized and a catalytically effective combination of cobalt, manganese, and bromide...
9580393 6-substituted quinazolinone inhibitors  
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
US20170051000 C-TERMINAL HSP90 INHIBITORS  
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of...
US20170049079 MODULAR FORCE SENSOR SYSTEM, DEVICE, AND METHOD FOR BEHAVIORAL MEASUREMENT  
Implementations of the present invention relate to for analyzing behavior of small live test subjects. More specifically, methods and devices of the present invention can allow a researcher to use...
9573983 Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders  
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune...
US20170044425 STABILITY IMPROVEMENT OF CO2 FOAM FOR ENHANCED OIL RECOVERY APPLICATIONS USING POLYELECTROLYTES AND POLYELECTROLYTE COMPLEX NANOPARTICLES  
Polyelectrolyte nanoparticles are generated to stabilize foam for use in enhanced oil recovery. Stability is further enhanced by optimizing pH and a ratio of polycationic and polyanioinic...
9567570 Assays using a multi-divot platform and multi-source, multi-cell type clusters  
Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and...
US20170029421 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
US20170028073 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
US20170028072 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
9556294 Magnetic particle-polymer hybrid materials with functionalized polymers derived from norbornenyl reagents  
A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP)m (Formula 1), wherein: Z is a magnetic particle smaller...
US20170021399 LABORATORY FUME HOOD SYSTEM HAVING RECESSED HEAT EXCHANGER SYSTEM  
A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a...
D776571 Aerial vehicle  
9545413 Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug  
A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically...
US20170007684 BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS  
Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1 moiety and the first polymer carrier is...
9541429 Systems, methods, and devices for fluid data sensing  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
9540375 Kappa opioid receptor effectors and uses thereof  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20170001197 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES  
A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly...
9533150 Methods and associated neural prosthetic devices for bridging brain areas to improve function  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
9526674 Maneuverable nasoenteric feeding tube  
A maneuverable feeding tube system can include: a feeding tube having an internal lumen and distal opening; a maneuverable tube having a flexible distal end being located within the internal lumen...
US20160355727 NANO-PROPPANTS FOR FRACTURE CONDUCTIVITY  
Methods of hydraulic fracturing are disclosed. One method of hydraulic fracturing which is performed on a geologic stratum includes using a nano-proppant dominantly formed of particles having an...
9512400 Reprogramming of human whartons jelly cells to produce hair cells  
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells...
US20160347715 Toll-Like Receptor 8 Agonists  
Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for...