Patents and Patent Applications from University of Kansas


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US20160244658 CROSSLINKING OF SWELLABLE POLYMER WITH PEI  
The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and...
US20160244457 SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT  
The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated...
9422320 C-terminal HSP90 inhibitors  
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of...
US20160235892 DECELLULARIZED HYALINE CARTILAGE POWDER FOR TISSUE SCAFFOLDS  
The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and...
9416802 Radar energy absorbing deformable low drag vortex generator  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9416103 Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases  
Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds...
9409164 Tray for tissue biopsy samples, methods of making, and methods of using thereof  
A tissue tray for collecting and organizing tissue biopsy samples as they are analyzed and prepared for histological analysis and other analyses. A tissue tray includes an upper surface and a...
9408372 Modular force sensor system, device, and method for behavioral measurement  
Implementations of the present invention relate to for analyzing behavior of small live test subjects. More specifically, methods and devices of the present invention can allow a researcher to use...
US20160220655 Use of the Salmonella SPP Type III Secretion Proteins as a Protective Vaccination  
Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.
9402861 Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
US20160213306 SYSTEMS AND METHODS FOR TONGUE-PALATE PRESSURE MEASUREMENT  
A device for measuring the pressure applied between a user's tongue and palate includes a body shaped to fit complimentarily against the user's palate and a pressure sensor affixed to the body...
US20160209022 HEATED LENS LIGHTING ARRANGEMENT  
According to aspects of the embodiments, a lighting fixture is designed to help prevent the accumulation of snow or ice on the light emitting face {e.g., lens) of the lighting fixture. The...
9378662 Simplified spine testing device  
A sample testing device includes a motor, a gear reducer, and an output shaft coupled for rotation by the motor via the gear reducer. The sample testing device further includes a first device...
9376452 Rab7 GTPase inhibitors and related methods of treatment  
This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer,...
9351667 Device, system, and method for determination of oral/lip stiffness  
A device for measuring orofacial stiffness in a subject can include: two lip saddle attachment components configured for attachment to the lip saddles of a patients mouth; two elongate members,...
9346839 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9345703 Kappa opioid receptor effectors and uses thereof  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20160137906 DELAYED GELATION OF POLYMERS  
The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying...
US20160130222 INHIBITORS OF THE MITF MOLECULAR PATHWAY  
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
US20160115371 LOW MOLECULAR WEIGHT POLYACRYLATES FOR EOR  
The disclosure is directed to low molecular weight polyelectrolyte complex nanoparticles that can be used to deliver agents deep into hydrocarbon reservoirs. Methods of making and using said...
US20160095870 METHODS OF FORMING CYCLOPIROX OR DERIVATIVES THEREOF IN A SUBJECT BY ADMINISTRATION OF PRODRUG  
A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically...
9289760 Apparatus for providing coolant fluid  
An apparatus for providing coolant fluid to a device, the apparatus includes a heat exchanger having a hot side and a cold side. The cold side is in fluid communication with a chilled fluid supply...
US20160076982 AUTOMATED VITRIFICATION DEVICE  
The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require...
US20160075669 CYCLOPHILIN D INHIBITORS  
A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof,...
US20160069994 SENSE-AND-AVOID SYSTEMS AND METHODS FOR UNMANNED AERIAL VEHICLES  
A sense-and-avoid system, for an unmanned air vehicle (UAV), configured to detect and estimate the relative position and velocity of a nearby object and to enable determination whether the nearby...
US20160068821 CHIMERIC ADENO-ASSOCIATED VIRUS/ BOCAVIRUS PARVOVIRUS VECTOR  
The invention provides an isolated chimeric virus comprising bocavirus capsid protein and a recombinant adeno-associated viral (AAV) genome, an isolated rBoV comprising human bocavirus capsid...
9278069 Nanoclusters compositions and methods  
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of...
US20160063372 SYSTEMS AND METHODS FOR ENHANCING COMPUTER ASSISTED HIGH THROUGHPUT SCREENING PROCESSES  
Embodiments are directed to identifying active compounds for a targeted medium from a library of compounds. In one scenario, a computer system receives high throughput screening (HTS) data for a...
9272911 Production of graphene nanoribbons with controlled dimensions and crystallographic orientation  
Graphene particulates, especially graphene nanoribbons (GNRs) and graphene quantum dots (GQDs), and a high-throughput process for the production of such particulates is provided. The graphene...
9267075 Swellable polymer with anionic sites  
The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable...
US20160040288 APPARATUS FOR IN SITU DEPOSITION OF MULTILAYER STRUCTURES VIA ATOMIC LAYER DEPOSITION AND ULTRA-HIGH VACUUM PHYSICAL OR CHEMICAL VAPOR DEPOSITION  
An apparatus for in situ fabrication of multilayer heterostructures is provided comprising a first vacuum chamber adapted for atomic layer deposition and comprising a first stage docking assembly...
US20160038643 HYDROGEL PRECURSORS HAVING NANOPARTICLES  
An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The...
US20160031929 INHIBITORS OF CYP17A1  
Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting...
US20160030484 MAMMALIAN PLURIPOTENT STEM CELLS, METHODS FOR THEIR PRODUCTION, AND USES THEREOF  
The disclosure relates to nerve derived adult pluripotent stem cells characterized by expression of Oct4, Sox2, c-Myc, and Klf4, methods for obtaining them, and their use.
US20160023759 MOVABLE MEMBER BEARING AERIAL VEHICLES AND METHODS OF USE  
An aerial vehicle includes a body having a longitudinal axis, a plurality of movable members emanating connected to the body, at least one motor, and at least three aerodynamic propulsors driven...
US20160023743 FLAT-STOCK AERIAL VEHICLES AND METHODS OF USE  
A flat-stock aerial vehicle includes a body having a plurality of flat-stock sheets connected to one another, at least one motor, and at least three aerodynamic propulsors driven by the at least...
9243014 Method of treatment with prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin in-2-1H-one and derivatives thereof  
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition...
US20160016652 AERIAL VEHICLES AND METHODS OF USE  
An aerial vehicle capable of convertible flight from hover to linear flight includes a body having a longitudinal body axis, a plurality of forward wings, a plurality of aft wings, at least one...
9238608 Spray process for selective oxidation  
Oxidation process can include: introducing small droplets of liquid reaction mixture having oxidizable reactant, catalyst, and solvent into a reaction zone containing oxygen and diluent gas; and...
9233944 Alkylene epoxidation with mesoporous catalysts  
A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible...
US20160000903 NEUROATTENUATED HERPES SIMPLEX VIRUS  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
9228925 Automated vitrification device  
The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require...
US20150369796 METASTASIS MIMETIC DEVICE  
Implementations of the present invention relate to apparatuses, systems, and methods for constructing and using a metastatic mimetic device. The device includes at least one chamber with a gate...
US20150346005 SYSTEMS, METHODS, AND DEVICES FOR FLUID DATA SENSING  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
US20150340166 INTEGRATED PHOTOVOLTAIC-BATTERY DEVICE AND RELATED METHODS  
Provided are FeS2 based photovoltaic battery devices comprising a transparent substrate, an active layer disposed over the transparent substrate, the active layer comprising a porous film of FeS2...
US20150337550 METHOD AND APPARATUS FOR REINFORCING STRUCTURAL CONNECTIONS  
A method and apparatus for strengthening structural connections can comprise connection member having a distal portion and a proximate end with the distal portion having at least one proximally...
US20150337009 TOLL-LIKE RECEPTOR 2-AGONISTIC LIPOPEPTIDES, AND METHOD OF MAKING THE SAME  
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These...
US20150329499 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
US20150329200 RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9187735 Metal abstraction peptide with superoxide dismutase activity  
Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various...