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Patents and Patent Applications from University of Kansas


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8691736 Swellable polymer with cationic sites  
The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising...
8685966 GRP94 inhibitors  
The present disclosure provides a series of compounds which exhibit isoform selective inhibition of GRP94, a homologue of Hsp90 that is localized to the endoplasmic recticulum. Through GRP94...
US20140088144 INHIBITING MICROBIAL INFECTIONS  
A method of inhibiting a microbial infection can include: providing a compound of the invention or prodrugs or pharmaceutically acceptable salts thereof; and administering the compound to a subject...
US20140081050 SINGLE SOLVENT GAS EXPANDED HYDROFORMYLATION PROCESS  
Allyl alcohol, particularly from biobased sources such as glycerol, is hydroformylated to products including 4-hydroxybutyraldehyde and 4-hydroxy-2-methylpropionaldehyde by forming a homogeneous...
8673584 Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase  
A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal...
8669214 Swellable polymer with anionic sites  
The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable...
8669107 Method of preparing a tissue engineering scaffold comprising a plurality of microspheres linked together  
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of...
US20140058593 LOW-ALTITUDE ALTIMETER AND METHOD  
A low-altitude altimeter (10) and a method of determining low altitudes for unmanned aerial vehicles (24). The altimeter includes at least two illuminators (12, 14), at least one sensor (16), and a...
8653975 Radio-frequency identification device with foam substrate  
The present invention encompasses an antenna (12) for use with a radio-frequency identification transponder (10) that performs optimally in free space and near optimally when near a conductive...
US20140046231 MEDICAL DEVICE FOR THERAPEUTIC STIMULATION OF THE VESTIBULAR SYSTEM  
A method for providing vestibular stimulation includes: providing an infant in a vestibular stimulation device; associating sensors to the infant; moving the vestibular stimulation device to...
US20140045851 MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13  
A method of inhibiting formation of cancerous metabolites, of inhibiting cytochrome P450 2A13 from forming carcinogen metabolites, and/or inhibiting formation of cancerous lung cells in a subject...
US20140037626 Metal Abstraction Peptide With Release of Metal  
Compositions comprising peptides that are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed. Such compositions can be used for...
8637468 Synthetic cholesterylamine-linker derivatives for agent delivery into cells  
Synthetic cholesterylamine-linkers can include derivatives of cholesterol, cholesteryl, or sitosteryl coupled through the linker to an agent for delivery into cells. The cholesterylamines are...
US20140008447 MICROSTRIP ANTENNA FOR RFID DEVICE HAVING BOTH FAR-FIELD AND NEAR-FIELD FUNCTIONALITY  
Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10). A balanced feed design using balanced feeds coupled by a shorting stub (56) to create a...
US20140005132 CONTRACEPTIVE AGENTS  
The invention provides compounds of formula I, II, III, or IV: wherein R1 to R11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase α4 and are useful ...
US20130341281 Surface Modified Ceramic Filter  
A porous ceramic filter having one or more coatings of elemental or compounds of iron, manganese, aluminum, titanium, or mixtures thereof deposited on the surface of the pores.
8609637 Prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-(1H)-one and derivatives thereof  
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition...
8608479 Systems and methods for facilitating gait training  
In one embodiment a gait training system includes a patient interface adapted to attach to a patient's thigh, the patient interface defining a channel, a cord that passes through the channel of the...
US20130331018 Laboratory Fume Hood System Having Recessed Heat Exchanger System  
A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a...
US20130330314 Metal Abstraction Peptide With Superoxide Dismutase Activity  
Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various...
US20130319410 INHALATION DEVICE, SYSTEMS, AND METHODS FOR ADMINISTERING POWDERED MEDICAMENTS TO MECHANICALLY VENTILATED SUBJECTS  
Inhalation devices, systems, and methods for the administration of powdered medicaments to mechanically ventilated subjects are provided. In one embodiment, an inhalation device adaptively...
8598339 Withanolide isolated from Physalis longifolia and analogs and methods of use thereof  
The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and...
8598165 Morpholines as selective inhibitors of cytochrome P450 2A13  
A method of inhibiting formation of cancerous metabolites, of inhibiting cytochrome P450 2A13 from forming carcinogen metabolites, and/or inhibiting formation of cancerous lung cells in a subject...
US20130316392 IN VITRO TUMOR IN DISH KIT AND METHOD  
This invention is a method and kit for preparing a Tumor in Dish model for use in screening anti-cancer agents and analyzing cancer growth and development.
8583296 Low-altitude altimeter and method  
A low-altitude altimeter (10) and a method of determining low altitudes for unmanned aerial vehicles (24). The altimeter includes at least two illuminators (12,14), at least one sensor (16), and a...
US20130296190 PREDICTION OF SPONTANEOUS PRETERM BIRTH BY MEASURING CELL FREE NUCLEIC ACIDS IN MATERNAL BLOOD  
A nucleic acid normalization kit can include a nucleic acid having a normalization sequence including or complementary to one or more of SEQ ID NOs: 1-4 and 301-303 or unique segment thereof, the...
8568747 Enalapril compositions  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
US20130280720 TISSUE BIOMARKERS FOR INDICATION OF PROGRESSION FROM BARRETT'S ESOPHAGUS TO ESOPHAGEAL ADENOCARCINOMA  
A method of diagnosing progression from Barrett's esophagus toward esophageal dysplasia can include: obtaining miRNA from a test subject having Barrett's esophagus; assaying for miRNA biomarker...
8564439 Microstrip antenna for RFID device  
Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10). A balanced feed design using balanced feeds coupled by a shorting stub (56) to create a...
US20130264542 Multiwall Carbon Nanotube Opto-Electronic Devices  
A high-sensitivity detector for opto-electronic detection using multiwall carbon nanotubes (MWCNTs) is provided. More specifically, multiwall carbon nanotube films demonstrate an infrared...
US20130240781 Ozonolysis Reactions in Liquid CO2 and CO2-Expanded Solvents  
A method for increasing ozone concentration in a liquid can include: providing a gas having ozone; introducing the ozone-containing gas into a liquid, wherein the liquid and ozone combination has a...
US20130231300 Purified Crocetin Compound And Method For Treating, Inhibiting, And/Or Prophylaxis of Cancer, Such As Pancreatic Cancer  
A fraction separated from crude crocetin by preparative HPLC, and identified using LC/MS and NMR as crocetinic acid, markedly regressed the proliferation and increased apoptosis in pancreatic...
US20130218121 MEDICATION ACCESS DEVICE FOR PREVENTION OF MEDICATION RESERVOIR CONTAMINATION  
A safety-engineered, one-time use, syringe adaptor-connector system restricts access to medical vials and intravenous bags (e.g., common reservoirs) using a valve and providing a barrier to...
US20130216621 BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS  
Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1 moiety and the first polymer carrier is...
8512862 Polyvinyl formamide (PNVF) and polyvinyl amine (PVAm)nanoparticles, nanocapsules and nanogels  
Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nan...
US20130195791 CONJUGATES COMPRISING AN N-OXIME BOND AND ASSOCIATED METHODS  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least o...
US20130189519 Drug and Imaging Agent Delivery Compositions and Methods  
A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical...
US20130184768 COMPACT ORTHOPEDIC ANTI-ROTATION DEVICE  
Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation...
US20130183327 COMPOSITIONS INCLUDING I-DOMAIN ANTIGEN CONJUGATE COMPOUNDS AND METHODS FOR TREATMENT OF AUTOIMMUNE DISORDERS  
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune...
8486981 Selective ligands for the dopamine 3 (D3) receptor and methods of using the same  
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is...
US20130151040 LOW-ALTITUDE ALTIMETER AND METHOD  
A low-altitude altimeter (10) and a method of determining low altitudes for unmanned aerial vehicles (24). The altimeter includes at least two illuminators (12,14), at least one sensor (16), and a...
US20130150330 DECOQUINATE PRODRUGS  
A compound can include a structure having decoquinate coupled to a prodrug moiety, or derivative or isomer or pharmaceutically acceptable salt thereof. The compound can be a decoquinate prodrug....
US20130143920 Methods for treatment of diseases and disorders related to transducin beta-like protein 1 (TBL1) activity, including myeloproliferative neoplasia and chronic myeloid leukemia.  
Methods for treatment of diseases and disorders related to transducin β-like protein 1 (TBL1) activity, including myeloproliferative neoplasia, chronic myeloid leukemia, and acute myeloid leukemia.
US20130123296 LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT  
Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include...
US20130123149 Polyelectrolyte Complexes for Oil and Gas Applications  
A polyelectrolyte complex for the controlled release of an oil and gas field chemical selected from the group consisting of (a) a gel-forming or cross-linking agent, (b) a scale inhibitor, (c) a...
US20130109684 GRP94 INHIBITORS  
The present disclosure provides a series of compounds which exhibit isoform selective inhibition of GRP94, a homologue of Hsp90 that is localized to the endoplasmic recticulum. Through GRP94...
US20130109031 INHIBITOR SCAFFOLD FOR THE INHIBITION OF THE ENZYME PHOSPHOENOLPYRUVATE CARBOXYKINASE  
A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal...
US20130108523 TRAY FOR TISSUE BIOPSY SAMPLES, METHODS OF MAKING, AND METHODS OF USING THEREOF  
A tissue tray for collecting and organizing tissue biopsy samples as they are analyzed and prepared for histological analysis and other analyses. A tissue tray includes an upper surface and a...
8433388 Source affine reconstruction for medical imaging  
Performing medical imaging. The generation of medical images, which includes a Source AFFine Image REconstruction (SAFFIRE) algorithm, is based on an iterative implementation of minimum mean-square...
US20130099196 Semiconductor-Graphene Hybrids Formed Using Solution Growth  
A novel method for fabrication of hybrid semiconductor-graphene nanostructures in large scale by floating graphene sheets on the surface of a solution is provided. Using this approach, crystalline...
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