Patents and Patent Applications from University of Kansas


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9828587 Chimeric adeno-associated virus/ bocavirus parvovirus vector  
The invention provides an isolated chimeric virus comprising bocavirus capsid protein, e.g., an isolated chimeric virus comprising human bocavirus capsid protein, and a recombinant...
US20170334892 LKB1-AMPK ACTIVATORS FOR THERAPEUTIC USE IN POLYCYSTIC KIDNEY DISEASE  
Compounds are provided for use in treating polycystic kidney disease (PKD) and in associated methods that include a method of modulating (e.g., activating) Liver kinase B1 (LKBI); and a method of...
US20170334889 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
US20170334842 INHIBITORS OF THE MITF MOLECULAR PATHWAY  
Provided herein are compounds of the formula (IV): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
9825315 Hydrophobized gas diffusion layers and method of making the same  
A gas diffusion layer having a first major surface and a second major surface which is positioned opposite to said first major surface and an interior between said first and second major surfaces...
US20170327313 SYSTEM AND METHODS FOR ARCHIVING AND RETRIEVING SPECIMENS  
Embodiments of the present invention include a system and methods for archiving and/or retrieving specimens. Embodiments of the system of the present invention include a movement mechanism, an...
9814802 Method for promoting hair growth comprising implanting a tissue scaffold comprising CK-19 positive cells derived from Wharton's jelly mesenchymal stromal cells  
A method of differentiating cells into CK19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the...
US20170314142 MICROWAVE ASSISTED SYNTHESIS OF METAL OXYHYDROXIDES  
A method for making a metal oxyhydroxide electrocatalytic material comprises titrating a precursor solution with a (bi)carbonate salt, the precursor solution comprising a first metal salt and a...
US20170313692 AGONISTS OF THE MU OPIOID RECEPTOR  
The present technology is directed to compounds, compositions, and methods related to non-morphinan-like mu opioid receptor agonists. Compounds of the present technology demonstrate remarkable...
US20170312552 METHOD AND APPARATUS FOR REMOVING MICROVESSELS  
A method of removing microvessels includes applying a burst of acoustic energy at a target location, applying a pulse of optical energy at the target location, and promoting cavitation at the...
9806212 Ultrathin group II-VI semiconductor layers, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the same, and related methods  
Disclosed are ultrathin layers of group II-VI semiconductors, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the layers and superlattice structures and...
US20170304329 METHODS OF BLADDER CANCER TREATMENT WITH CICLOPIROX, CICLOPIROX OLAMINE, OR A CICLOPIROX PRODRUG  
A method of treating bladder cancer is provided. The method of treating bladder cancer can include: providing a pharmaceutical composition having ciclopirox or ciclopirox olamine or a...
9796909 Nanogels for delayed gelation  
The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions...
US20170260192 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170260184 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
US20170260141 ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR  
The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction,...
9757539 Barrier system to reduce the rate of line-related infections  
A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percutaneous incision. Such a barrier...
9757307 Medication access device for prevention of medication reservoir contamination  
A safety-engineered, one-time use, syringe adaptor-connector system restricts access to medical vials and intravenous bags (e.g., common reservoirs) using a valve and providing a barrier to...
US20170253582 TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS  
Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may...
9745261 Inhibitors of the MITF molecular pathway  
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
9738668 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9738615 Cyclophilin D inhibitors  
A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof,...
9732067 Compounds and methods for activating the apoptotic arm of the unfolded protein response  
N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is...
9731982 Surface modified ceramic filter  
A porous ceramic filter having one or more coatings of elemental or compounds of iron, manganese, aluminum, titanium, or mixtures thereof deposited on the surface of the pores.
US20170218022 TARGETED CONFORMATIONALLY-CONSTRAINED KINKED ENDOSOMAL DISRUPTING PEPTIDES  
A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the...
US20170216092 CANNULA FOR EXTERNAL DRAINAGE OF SUBRETINAL FLUID  
A cannula device for draining sub-retinal fluid externally to the eye includes a shaft, an outer sleeve, and an inner sleeve. The outer sleeve and the inner sleeve have a curve therein to access...
9722110 Plasmonic graphene and method of making the same  
Plasmonic graphene is fabricated using thermally assisted self-assembly of plasmonic nanostructure on graphene. Silver nanostructures were deposited on graphene as an example.
US20170210971 LOW PH CROSSLINKING OF POLYMERS  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
US20170209565 NEUROATTENUATED HERPES SIMPLEX VIRUS  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
US20170209483 ANTIBIOTIC ACTIVITY OF IRON SEQUESTERING POLYMERS  
A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a...
US20170199269 TECHNIQUES FOR NAVIGATING UAVs USING GROUND-BASED TRANSMITTERS  
Systems, methods, apparatuses and computer-readable storage media for navigating an unmanned aerial vehicle (UAV) using signals of opportunity are disclosed. The UAV may include a receiver for...
9701715 Conformationally-constrained kinked endosomal-disrupting peptides  
A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally...
US20170190738 CYCLIC TETRAPEPTIDE STEREOISOMERS  
Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide...
US20170189555 SYSTEM AND METHOD FOR WOUND ARRAY VARIABLES EVALUATION (WAVE)  
A system and method for evaluating wound healing dressings, treatments, and other variables. The present invention includes in vitro systems and methods for testing wound dressing materials for...
US20170181968 ENALAPRIL COMPOSITIONS  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
9688653 Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections  
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule...
US20170176450 SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN STABILIZERS  
A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a...
US20170166557 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
9677580 Radar energy absorbing deformable low drag vortex generator  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9676818 Toll-like receptor 2-agonistic lipopeptides, and method of making the same  
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These...
9675636 Micelle sequestering polymers  
A polymer composition for sequestering lipid-bile acid micelles in the gastrointestinal (GI) tract is provided. The polymer composition comprises a copolymer of a pH-sensitive monomer and one or...
9670247 Contraceptive agents  
The invention provides compounds of formula I, II, III, or IV: wherein R1 to R11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase α4 and are useful...
9663521 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170145043 DEPOLYMERIZATION OF LIGNIN USING METAL INCORPORATED MESOPOROUS SILICATE CATALYSTS  
Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid mesoporous silicate catalyst under...
US20170144965 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT  
A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective...
US20170137115 RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
US20170135683 SOLENOID OCCLUSION DEVICE  
The present disclosure relates to devices and methods for delivery of a ferrofluid to a targeted treatment site, such as delivery of a ferroadhesive to a pathological fistula to occlude the...
9644136 Low pH crosslinking of polymers  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
9642835 Modulators of GTPase and use in relevant treatment  
The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous (Rho) family of small GTPases, in...
US20170122973 SYSTEMS, METHODS, AND DEVICES FOR FLUID DATA SENSING  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...