Patents and Patent Applications from University of Kansas


Match Document Document Title
US20170260192 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170260184 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
US20170260141 ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR  
The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction,...
9757539 Barrier system to reduce the rate of line-related infections  
A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percutaneous incision. Such a barrier...
9757307 Medication access device for prevention of medication reservoir contamination  
A safety-engineered, one-time use, syringe adaptor-connector system restricts access to medical vials and intravenous bags (e.g., common reservoirs) using a valve and providing a barrier to...
US20170253582 TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS  
Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may...
9745261 Inhibitors of the MITF molecular pathway  
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
9738668 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9738615 Cyclophilin D inhibitors  
A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof,...
9732067 Compounds and methods for activating the apoptotic arm of the unfolded protein response  
N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is...
9731982 Surface modified ceramic filter  
A porous ceramic filter having one or more coatings of elemental or compounds of iron, manganese, aluminum, titanium, or mixtures thereof deposited on the surface of the pores.
US20170218022 TARGETED CONFORMATIONALLY-CONSTRAINED KINKED ENDOSOMAL DISRUPTING PEPTIDES  
A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the...
US20170216092 CANNULA FOR EXTERNAL DRAINAGE OF SUBRETINAL FLUID  
A cannula device for draining sub-retinal fluid externally to the eye includes a shaft, an outer sleeve, and an inner sleeve. The outer sleeve and the inner sleeve have a curve therein to access...
9722110 Plasmonic graphene and method of making the same  
Plasmonic graphene is fabricated using thermally assisted self-assembly of plasmonic nanostructure on graphene. Silver nanostructures were deposited on graphene as an example.
US20170210971 LOW PH CROSSLINKING OF POLYMERS  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
US20170209565 NEUROATTENUATED HERPES SIMPLEX VIRUS  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
US20170209483 ANTIBIOTIC ACTIVITY OF IRON SEQUESTERING POLYMERS  
A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a...
US20170199269 TECHNIQUES FOR NAVIGATING UAVs USING GROUND-BASED TRANSMITTERS  
Systems, methods, apparatuses and computer-readable storage media for navigating an unmanned aerial vehicle (UAV) using signals of opportunity are disclosed. The UAV may include a receiver for...
9701715 Conformationally-constrained kinked endosomal-disrupting peptides  
A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally...
US20170190738 CYCLIC TETRAPEPTIDE STEREOISOMERS  
Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide...
US20170189555 SYSTEM AND METHOD FOR WOUND ARRAY VARIABLES EVALUATION (WAVE)  
A system and method for evaluating wound healing dressings, treatments, and other variables. The present invention includes in vitro systems and methods for testing wound dressing materials for...
US20170181968 ENALAPRIL COMPOSITIONS  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
9688653 Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections  
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule...
US20170176450 SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN STABILIZERS  
A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a...
US20170166557 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
9677580 Radar energy absorbing deformable low drag vortex generator  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9676818 Toll-like receptor 2-agonistic lipopeptides, and method of making the same  
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These...
9675636 Micelle sequestering polymers  
A polymer composition for sequestering lipid-bile acid micelles in the gastrointestinal (GI) tract is provided. The polymer composition comprises a copolymer of a pH-sensitive monomer and one or...
9670247 Contraceptive agents  
The invention provides compounds of formula I, II, III, or IV: wherein R1 to R11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase α4 and are useful...
9663521 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170145043 DEPOLYMERIZATION OF LIGNIN USING METAL INCORPORATED MESOPOROUS SILICATE CATALYSTS  
Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid mesoporous silicate catalyst under...
US20170144965 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT  
A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective...
US20170137115 RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
US20170135683 SOLENOID OCCLUSION DEVICE  
The present disclosure relates to devices and methods for delivery of a ferrofluid to a targeted treatment site, such as delivery of a ferroadhesive to a pathological fistula to occlude the...
9644136 Low pH crosslinking of polymers  
The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs,...
9642835 Modulators of GTPase and use in relevant treatment  
The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous (Rho) family of small GTPases, in...
US20170122973 SYSTEMS, METHODS, AND DEVICES FOR FLUID DATA SENSING  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
US20170121719 DEREPLICATION STRAIN OF ASPERGILLUS NIDULANS  
Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include A. nidulans. The deleted gene clusters are selected from the group of gene clusters...
9636419 Targeting multiple receptors on a cell surface for specific cell targeting  
A method of delivering a cargo agent into cytosol of a cell can include: providing the delivery system of one of the embodiments described herein having the first and second delivery platforms;...
US20170114053 HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF  
Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for...
US20170107497 IMPROVED RELIABILITY OF ASSAYS USING A MULTI-DIVOT PLATFORM AND MULTI-SOURCE, MULTI-CELL TYPE CLUSTERS  
Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and...
US20170100591 METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
9616119 Neuroattenuated herpes simplex virus  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
9611270 Inhibitors of CYP17A1  
Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting...
9601040 Flat-stock aerial vehicles and methods of use  
A flat-stock aerial vehicle includes a body having a plurality of flat-stock sheets connected to one another, at least one motor, and at least three aerodynamic propulsors driven by the at least...
9593095 Methods for the treatment of bacterial infections  
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule...
US20170067018 REPROGRAMMING OF HUMAN WHARTON'S JELLY CELLS TO PRODUCE HAIR CELLS  
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells...
US20170065978 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES  
A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly...
US20170065742 METHACRYLATED DEVITALIZED CARTILAGE AND DEVITALIZED CARTILAGE PARTICLES  
An implantable composition can include methacrylated solubilized devitalized cartilage (MeSDVC) with or without devitalized cartilage (DVC) particles. These compositions can be hydrogel...
US20170065540 METHODS AND COMPOSITIONS FOR TREATING INFECTION  
Provided herein are compositions and methods for treating or preventing infection.