Patents and Patent Applications from University of Kansas


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US20170051000 C-TERMINAL HSP90 INHIBITORS  
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of...
US20170049079 MODULAR FORCE SENSOR SYSTEM, DEVICE, AND METHOD FOR BEHAVIORAL MEASUREMENT  
Implementations of the present invention relate to for analyzing behavior of small live test subjects. More specifically, methods and devices of the present invention can allow a researcher to use...
9573983 Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders  
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune...
US20170044425 STABILITY IMPROVEMENT OF CO2 FOAM FOR ENHANCED OIL RECOVERY APPLICATIONS USING POLYELECTROLYTES AND POLYELECTROLYTE COMPLEX NANOPARTICLES  
Polyelectrolyte nanoparticles are generated to stabilize foam for use in enhanced oil recovery. Stability is further enhanced by optimizing pH and a ratio of polycationic and polyanioinic...
9567570 Assays using a multi-divot platform and multi-source, multi-cell type clusters  
Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and...
US20170029421 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
US20170028073 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
US20170028072 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
9556294 Magnetic particle-polymer hybrid materials with functionalized polymers derived from norbornenyl reagents  
A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP)m (Formula 1), wherein: Z is a magnetic particle smaller...
US20170021399 LABORATORY FUME HOOD SYSTEM HAVING RECESSED HEAT EXCHANGER SYSTEM  
A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a...
D776571 Aerial vehicle  
9545413 Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug  
A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically...
US20170007684 BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS  
Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1 moiety and the first polymer carrier is...
9541429 Systems, methods, and devices for fluid data sensing  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
9540375 Kappa opioid receptor effectors and uses thereof  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20170001197 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES  
A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly...
9533150 Methods and associated neural prosthetic devices for bridging brain areas to improve function  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
9526674 Maneuverable nasoenteric feeding tube  
A maneuverable feeding tube system can include: a feeding tube having an internal lumen and distal opening; a maneuverable tube having a flexible distal end being located within the internal lumen...
US20160355727 NANO-PROPPANTS FOR FRACTURE CONDUCTIVITY  
Methods of hydraulic fracturing are disclosed. One method of hydraulic fracturing which is performed on a geologic stratum includes using a nano-proppant dominantly formed of particles having an...
9512400 Reprogramming of human whartons jelly cells to produce hair cells  
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells...
9499496 Inhibitors of respiratory syncytial virus  
Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.
9494573 In vitro tumor in dish kit and method  
This invention is a method and kit for preparing a Tumor in Dish model for use in screening anti-cancer agents and analyzing cancer growth and development.
US20160317359 BARRIER SYSTEM TO REDUCE THE RATES OF INFECTIONS  
A barrier system is provided for use in reducing infections associated with post-operative surgical incision and/or a percutaneous medical device, such as a catheter, that is disposed within the...
9464064 HCV helicase inhibitors and methods of use thereof  
The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention...
9464035 Salicylic acid derivatives useful as glucocerebrosidase activators  
Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher...
9463495 Laboratory fume hood system having recessed heat exchanger system  
A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a...
US20160289217 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS  
Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are...
US20160279108 TARGETED MTOR INHIBITORS  
The present invention is directed to drug conjugates of mTOR inhibitors comprising an mTOR inhibitor, such as rapamycin, conjugated to hyaluronic acid by a linker comprising an ester, carbonate,...
US20160272584 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS  
Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In...
US20160263133 PHOSPHONATE DERIVATIVES AND METHODS OF USE THEREOF IN THE TREATMENT OF ALZHEIMER'S DISEASE  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9441005 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds  
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using...
US20160257685 KAPPA OPIOID RECEPTOR EFFECTORS AND USES THEREOF  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20160244658 CROSSLINKING OF SWELLABLE POLYMER WITH PEI  
The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and...
US20160244457 SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT  
The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated...
9422320 C-terminal HSP90 inhibitors  
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of...
US20160235892 DECELLULARIZED HYALINE CARTILAGE POWDER FOR TISSUE SCAFFOLDS  
The present invention is related to compositions comprising decellularized cartilage tissue powder in the forms of paste, putty, hydrogel, and scaffolds, methods of making compositions, and...
9416802 Radar energy absorbing deformable low drag vortex generator  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9416103 Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases  
Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds...
9409164 Tray for tissue biopsy samples, methods of making, and methods of using thereof  
A tissue tray for collecting and organizing tissue biopsy samples as they are analyzed and prepared for histological analysis and other analyses. A tissue tray includes an upper surface and a...
9408372 Modular force sensor system, device, and method for behavioral measurement  
Implementations of the present invention relate to for analyzing behavior of small live test subjects. More specifically, methods and devices of the present invention can allow a researcher to use...
US20160220655 Use of the Salmonella SPP Type III Secretion Proteins as a Protective Vaccination  
Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.
9402861 Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators  
Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than...
US20160213306 SYSTEMS AND METHODS FOR TONGUE-PALATE PRESSURE MEASUREMENT  
A device for measuring the pressure applied between a user's tongue and palate includes a body shaped to fit complimentarily against the user's palate and a pressure sensor affixed to the body...
US20160209022 HEATED LENS LIGHTING ARRANGEMENT  
According to aspects of the embodiments, a lighting fixture is designed to help prevent the accumulation of snow or ice on the light emitting face {e.g., lens) of the lighting fixture. The...
9378662 Simplified spine testing device  
A sample testing device includes a motor, a gear reducer, and an output shaft coupled for rotation by the motor via the gear reducer. The sample testing device further includes a first device...
9376452 Rab7 GTPase inhibitors and related methods of treatment  
This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer,...
9351667 Device, system, and method for determination of oral/lip stiffness  
A device for measuring orofacial stiffness in a subject can include: two lip saddle attachment components configured for attachment to the lip saddles of a patients mouth; two elongate members,...
9346839 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9345703 Kappa opioid receptor effectors and uses thereof  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20160137906 DELAYED GELATION OF POLYMERS  
The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying...