Patents and Patent Applications from University of Kansas


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9346839 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
9345703 Kappa opioid receptor effectors and uses thereof  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...
US20160137906 DELAYED GELATION OF POLYMERS  
The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying...
US20160130222 INHIBITORS OF THE MITF MOLECULAR PATHWAY  
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
US20160115371 LOW MOLECULAR WEIGHT POLYACRYLATES FOR EOR  
The disclosure is directed to low molecular weight polyelectrolyte complex nanoparticles that can be used to deliver agents deep into hydrocarbon reservoirs. Methods of making and using said...
US20160095870 METHODS OF FORMING CYCLOPIROX OR DERIVATIVES THEREOF IN A SUBJECT BY ADMINISTRATION OF PRODRUG  
A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically...
9289760 Apparatus for providing coolant fluid  
An apparatus for providing coolant fluid to a device, the apparatus includes a heat exchanger having a hot side and a cold side. The cold side is in fluid communication with a chilled fluid supply...
US20160076982 AUTOMATED VITRIFICATION DEVICE  
The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require...
US20160075669 CYCLOPHILIN D INHIBITORS  
A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof,...
US20160069994 SENSE-AND-AVOID SYSTEMS AND METHODS FOR UNMANNED AERIAL VEHICLES  
A sense-and-avoid system, for an unmanned air vehicle (UAV), configured to detect and estimate the relative position and velocity of a nearby object and to enable determination whether the nearby...
US20160068821 CHIMERIC ADENO-ASSOCIATED VIRUS/ BOCAVIRUS PARVOVIRUS VECTOR  
The invention provides an isolated chimeric virus comprising bocavirus capsid protein and a recombinant adeno-associated viral (AAV) genome, an isolated rBoV comprising human bocavirus capsid...
9278069 Nanoclusters compositions and methods  
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of...
9272911 Production of graphene nanoribbons with controlled dimensions and crystallographic orientation  
Graphene particulates, especially graphene nanoribbons (GNRs) and graphene quantum dots (GQDs), and a high-throughput process for the production of such particulates is provided. The graphene...
9267075 Swellable polymer with anionic sites  
The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable...
US20160040288 APPARATUS FOR IN SITU DEPOSITION OF MULTILAYER STRUCTURES VIA ATOMIC LAYER DEPOSITION AND ULTRA-HIGH VACUUM PHYSICAL OR CHEMICAL VAPOR DEPOSITION  
An apparatus for in situ fabrication of multilayer heterostructures is provided comprising a first vacuum chamber adapted for atomic layer deposition and comprising a first stage docking assembly...
US20160038643 HYDROGEL PRECURSORS HAVING NANOPARTICLES  
An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The...
US20160031929 INHIBITORS OF CYP17A1  
Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting...
US20160030484 MAMMALIAN PLURIPOTENT STEM CELLS, METHODS FOR THEIR PRODUCTION, AND USES THEREOF  
The disclosure relates to nerve derived adult pluripotent stem cells characterized by expression of Oct4, Sox2, c-Myc, and Klf4, methods for obtaining them, and their use.
9243014 Method of treatment with prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin in-2-1H-one and derivatives thereof  
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition...
9238608 Spray process for selective oxidation  
Oxidation process can include: introducing small droplets of liquid reaction mixture having oxidizable reactant, catalyst, and solvent into a reaction zone containing oxygen and diluent gas; and...
9233944 Alkylene epoxidation with mesoporous catalysts  
A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible...
US20160000903 NEUROATTENUATED HERPES SIMPLEX VIRUS  
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase...
9228925 Automated vitrification device  
The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require...
US20150369796 METASTASIS MIMETIC DEVICE  
Implementations of the present invention relate to apparatuses, systems, and methods for constructing and using a metastatic mimetic device. The device includes at least one chamber with a gate...
US20150346005 SYSTEMS, METHODS, AND DEVICES FOR FLUID DATA SENSING  
A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft...
US20150340166 INTEGRATED PHOTOVOLTAIC-BATTERY DEVICE AND RELATED METHODS  
Provided are FeS2 based photovoltaic battery devices comprising a transparent substrate, an active layer disposed over the transparent substrate, the active layer comprising a porous film of FeS2...
US20150337550 METHOD AND APPARATUS FOR REINFORCING STRUCTURAL CONNECTIONS  
A method and apparatus for strengthening structural connections can comprise connection member having a distal portion and a proximate end with the distal portion having at least one proximally...
US20150337009 TOLL-LIKE RECEPTOR 2-AGONISTIC LIPOPEPTIDES, AND METHOD OF MAKING THE SAME  
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These...
US20150329499 6-SUBSTITUTED QUINAZOLINONE INHIBITORS  
The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or...
US20150329200 RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR  
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface...
9187735 Metal abstraction peptide with superoxide dismutase activity  
Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various...
US20150322087 CEPHALOSPORIN DERIVATIVES AND METHODS OF USE  
This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.
US20150307837 REPROGRAMMING OF HUMAN WHARTONS JELLY CELLS TO PRODUCE HAIR CELLS  
A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells...
9166172 Multiwall carbon nanotube opto-electronic devices  
A high-sensitivity detector for opto-electronic detection using multiwall carbon nanotubes (MWCNTs) is provided. More specifically, multiwall carbon nanotube films demonstrate an infrared...
US20150274780 CONFORMATIONALLY-CONSTRAINED KINKED ENDOSOMAL-DISRUPTING PEPTIDES  
A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally...
US20150266820 USE OF THE AMINOALKYLINDOLE JWH-073-M4 AND RELATED COMPOUNDS AS NEUTRAL CB1 RECPTOR ANTAGONISTS FOR THE TREATMENT OF ALCOHOLISM, DRUG ABUSE, OBESITY, AND OBESITY-RELATED DISEASES  
Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds...
9139762 Swellable polymer with cationic sites  
The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition...
US20150259650 RELIABILITY OF ASSAYS USING A MULTI-DIVOT PLATFORM AND MULTI-SOURCE, MULTI-CELL TYPE CLUSTERS  
Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and...
US20150258027 ENALAPRIL COMPOSITIONS  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
9120774 Novobiocin analogues having modified sugar moieties  
The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.
US20150238473 METHODS AND COMPOSITIONS FOR TREATING INFECTION  
Provided herein are compositions and methods for treating or preventing infection.
US20150231397 METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
US20150230918 BIOMATERIAL BASED ON ALIGNED FIBERS, ARRANGED IN A GRADIENT INTERFACE, WITH MECHANICAL REINFORCEMENT FOR TRACHEAL REGENERATION AND REPAIR  
An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in...
US20150217936 SYSTEM AND METHODS FOR ARCHIVING AND RETRIEVING SPECIMENS  
Embodiments of the present invention include a system and methods for archiving and/or retrieving specimens. Embodiments of the system of the present invention include a movement mechanism, an...
US20150216896 MICELLE SEQUESTERING POLYMERS  
A polymer composition for sequestering lipid-bile acid micelles in the gastrointestinal (GI) tract is provided. The polymer composition comprises a copolymer of a pH-sensitive monomer and one or...
9096652 Metal abstraction peptide (MAP) tag and associated methods  
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal...
US20150214403 ULTRATHIN GROUP II-VI SEMICONDUCTOR LAYERS, GROUP II-VI SEMICONDUCTOR SUPERLATTICE STRUCTURES, PHOTOVOLTAIC DEVICES INCORPORATING THE SAME, AND RELATED METHODS  
Disclosed are ultrathin layers of group II-VI semiconductors, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the layers and superlattice structures and...
US20150203477 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
9085521 Catalyst system and process for converting glycerol to lactic acid  
A process for producing lactic acid from glycerol using a reaction mixture comprising glycerol, a dehydrogenation catalyst (preferably a copper-based catalyst), an alkaline component, and water.
US20150197526 SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT  
The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated...