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Patents and Patent Applications from University of Kansas


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9096652 Metal abstraction peptide (MAP) tag and associated methods  
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal...
US20150214403 ULTRATHIN GROUP II-VI SEMICONDUCTOR LAYERS, GROUP II-VI SEMICONDUCTOR SUPERLATTICE STRUCTURES, PHOTOVOLTAIC DEVICES INCORPORATING THE SAME, AND RELATED METHODS  
Disclosed are ultrathin layers of group II-VI semiconductors, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the layers and superlattice structures and...
US20150203477 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
9085521 Catalyst system and process for converting glycerol to lactic acid  
A process for producing lactic acid from glycerol using a reaction mixture comprising glycerol, a dehydrogenation catalyst (preferably a copper-based catalyst), an alkaline component, and water.
US20150197526 SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT  
The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated...
US20150191442 ALKYLENE EPOXIDATION WITH MESOPOROUS CATALYSTS  
A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible...
US20150190529 TARGETING MULTIPLE RECEPTORS ON A CELL SURFACE FOR SPECIFIC CELL TARGETING  
A method of delivering a cargo agent into cytosol of a cell can include: providing the delivery system of one of the embodiments described herein having the first and second delivery platforms;...
9075825 System and methods of integrating visual features with textual features for image searching  
The present invention includes a system and methods for image searching. Embodiments of the system integrate textual features and visual features for improved search performance. The system...
US20150183755 SPRAY OXIDATION PROCESS FOR PRODUCING 2,5-FURANDICARBOXYLIC ACID FROM HYDROXYMETHYLFURFURAL  
A process is provided for carrying out an oxidation on a sprayable feed including a furanic substrate to be oxidized and a catalytically effective combination of cobalt, manganese, and bromide...
US20150175725 MAGNETIC PARTICLE-POLYMER HYBRID MATERIALS WITH FUNCTIONALIZED POLYMERS DERIVED FROM NORBORNENYL REAGENTS  
A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP)m (Formula 1), wherein: Z is a magnetic particle smaller...
9056111 Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment  
The present invention provides pyrazolo[1,5-a]pyrimidine compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated...
9056104 Dynamic inhibitors of heat shock protein 90  
An inhibitor of heat shock protein 90 (HSP90) can include a coumermycin A1 analog having a structure that inhibits HSP90 greater than coumermycin A1. That is, the coumermycin A1 analog is not...
9052323 Osmolyte mixture for protein stabilization  
An osmolyte composition comprising 4 M glycerol and 4M urea for stabilizing previously transient protein folding intermediates as long-lived stable forms. A method to search for other possible...
US20150154490 DUAL MICROSTRIP ANTENNA FOR RFID DEVICE  
Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10) are disclosed. A balanced feed design using balanced feeds coupled by a shorting stub...
US20150151004 METHODS AND COMPOSITIONS OF MODULATING TUMOR INITIATING CELLS AND THE USE THEREOF  
A therapeutic vector can include: a lipid particle; a CD44 antigen targeting moiety associated with the lipid particle; and a therapeutic nucleic acid associated with the lipid particle. The CD44...
9045434 Compositions and methods of treatment for myocilin glaucoma by selectively inhibiting GRP94  
A compound and method for treating myocilin glaucoma using a selective Grp94 inhibitor is presented. Clearance of mutant myocilin can be promoted by selectively targeting the endoplasmic reticulum...
US20150140093 NANOCLUSTERS COMPOSITIONS AND METHODS  
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of...
US20150136149 BARRIER SYSTEM TO REDUCE THE RATE OF LINE-RELATED INFECTIONS  
A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percuteneous incision. Such a barrier...
9035003 High capacity magnetic nanoparticles as supports for reagents and catalysts  
A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof:Z(Y-Triazole-CH2—X—CH2—(FP)n)m (Formula 1), wherein Z is a...
US20150134061 PIEZOELECTRIC COMPOSITES AND METHODS OF MAKING  
There is a need for methods that can produce piezoelectric composites having suitable physical characteristics and also optimized electrical stimulatory properties. The present application...
9031406 Digital subcarrier cross-connect switching  
The present invention uses digital subcarrier cross-connect switching to accomplish various network processes more efficiently. These processes include interconnecting network components, and...
9029457 Silica-supported oligomeric hybrid materials  
A particle-polymer hybrid material can include: a substance having the structure of Formula 1 Z(Y-FP)m, wherein Z is a particle smaller than 1 mm; m is an integer; Y is a linker including a...
US20150122320 Plasmonic Graphene and Method of Making the Same  
Plasmonic graphene is fabricated using thermally assisted self-assembly of plasmonic nanostructure on graphene. Silver nanostructures were deposited on graphene as an example.
US20150119411 INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS  
Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.
US20150118178 CONJUGATES COMPRISING AN N-OXIME BOND AND ASSOCIATED METHODS  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least...
US20150111858 METHOD OF TREATMENT WITH PRODRUGS OF 6-CYCLOHEXYL-1-HYDROXY-4-METHYLPYRIDIN IN-2-1H-ONE AND DERIVATIVES THEREOF  
A prodrug can have a structure of Formula 10 or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof. The prodrug can be included in a pharmaceutical composition...
9008869 Low-altitude altimeter and method  
A low-altitude altimeter (10) and a method of determining low altitudes for unmanned aerial vehicles (24). The altimeter includes at least two illuminators (12, 14), at least one sensor (16), and...
9008780 Methods and associated neural prosthetic devices for bridging brain areas to improve function  
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a...
9004393 Supersonic hovering air vehicle  
Embodiments of the present invention include an aircraft capable of sustained out-of-ground-effect hover flight and sustained supersonic flight. At least some embodiments includes two wings...
US20150094216 SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN STABILIZERS  
A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a...
US20150087549 METHODS OF USING TISSUE BIOMARKERS FOR INDICATION OF PROGRESSION FROM BARRETTS ESOPHAGUS TO ESOPHAGEAL ADENOCARCINOMA  
A method of diagnosing progression from Barrett's esophagus toward esophageal dysplasia can include: obtaining miRNA from a test subject having Barrett's esophagus; assaying for miRNA biomarker...
US20150080333 HYALURONIC ACID PARTICLES AND THEIR USE IN BIOMEDICAL APPLICATIONS  
Hyaluronic acid particles and their use in biomedical applications are provided. In one embodiment, an HA particle comprising a plurality of free polymer chains extending from a surface of the...
8979896 Pacifier System for stimulating and entraining the human orofacial system  
This application discusses systems and method for entraining oromotor pattern development, such as the suck, in the orofacial system of an infant having neurological impairments or developmental...
8975082 Metal abstraction peptide (MAP) tag and associated methods  
Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal...
US20150065469 SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS  
Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher...
US20150065463 PHOSPHONATE DERIVATIVES AND METHODS OF USE THEREOF IN THE TREATMENT OF ALZHEIMER'S DISEASE  
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are...
8970378 Microstrip antenna for RFID device having both far-field and near-field functionality  
Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10). A balanced feed design using balanced feeds coupled by a shorting stub (56) to create a...
US20150057240 C-TERMINAL HSP90 INHIBITORS  
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of...
8962624 Morpholines as selective inhibitors of cytochrome P450 2A13  
A method of inhibiting formation of cancerous metabolites, of inhibiting cytochrome P450 2A13 from forming carcinogen metabolites, and/or inhibiting formation of cancerous lung cells in a subject...
US20150050309 VACCINE  
The present invention relates, in-general, to Human immunodeficiency virus (HIV), and in particular to a carbohydrate-based vaccine for HIV and to methods of making and using same.
8956604 Conjugates comprising an N-oxime bond and associated methods  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least...
US20150038358 METHODS FOR DETECTING TRISOMY 21  
Methods for determining whether a subject, such as a fetus, has Down syndrome are described. In one embodiment, the methods include detecting one or more biomarkers in a biological sample, and...
8945062 Barrier system to reduce the rates of line-related infections  
A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percutaneous incision. Such a barrier...
US20150031658 ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS  
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule...
US20150031571 CHEMILUMINESCENT NANOPARTICLES AND USES THEREOF  
Gold nanoparticles having luminol covalently linked thereto and optionally functionalized with an oligonucleotide and bacterial or viral detection assays. In one aspect, the detection system for...
8939919 Enhanced therapeutic stimulus system and methods of use  
The present invention relates to a therapeutic system and methods of using the therapeutic system. In particular, the present invention relates to systems having hardware, software, and appliance...
US20150024300 HYDROPHOBIZED GAS DIFFUSION LAYERS AND METHOD OF MAKING THE SAME  
A gas diffusion layer having a first major surface and a second major surface which is positioned opposite to said first major surface and an interior between said first and second major surfaces...
8921486 Polymer-supported transition metal catalyst complexes and methods of use  
A catalyst composition comprising a polymer functionalized with a ligand for binding a transition metal containing compound to form a transition metal complex, wherein said functionalized polymer...
8916174 HIV DNA vaccine regulated by a caev-derived promoter  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
US20140371227 KAPPA OPIOID RECEPTOR EFFECTORS AND USES THEREOF  
The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression,...