Patents and Patent Applications from University of Iowa


Match Document Document Title
US20180169298 PREVENTATIVE THERAPY FOR POST-TRAUMATIC OSTEOARTHRITIS  
Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits...
US20180169269 METHODS OF DELIVERY OF TRANSGENES FOR TREATING BRAIN DISEASES  
The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant...
US20180161434 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO TREAT DIARRHEA IN SUBJECTS WITH DISEASES OR TREATMENTS THAT RESULT IN ELEVATED CGRP LEVELS  
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and...
9987299 Methods of improving RNAi in well-differentiated airway epithelia  
The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by...
US20180147225 USE OF NAD PRECURSORS FOR BREAST ENHANCEMENT  
Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide...
US20180147224 METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT BLOCKADE THERAPY  
Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The...
9980951 Image guided therapy for cancer  
The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.
US20180142259 METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES  
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered...
US20180134746 NUCLEIC ACID APTAMERS TO TREAT HISTONE-INDUCED DISEASE STATES  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20180127783 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS  
Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9...
US20180118657 METHODS FOR INHIBITING MUSCLE ATROPHY  
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a...
US20180110456 Bladder Health Monitoring System and Related Methods and Devices  
The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health. Certain implementations are directed to patients who require daily catheterization....
9951102 Peptide inhibitor of Nox1 NADPH oxidase  
An isolated peptide or fusion having the peptide useful to interfere with the phosphorylation of Nox1, block or inhibit binding of NoxA1 activation domain (AD) to Nox1, and/or prevent or inhibit...
9950165 Method for causing stochastic depolarization in the spinal cord to inhibit transmission of synchronous action potentials  
This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory...
US20180108139 System And Method For N-Dimensional Image Segmentation Using Convolutional Neural Networks  
Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. The image hypervolume can be provided to a...
9943518 Inhibitors of phosphodiesterase type 5A for reducing skeletal muscle fatigue, edema, and damage in a patient having muscle fatigue due to increased age or exercise  
Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize...
9937182 Therapeutic strategies for the treatment of preeclampsia  
Compositions and methods for treating preeclampsia in a subject in need thereof are disclosed.
9937177 Therapeutic compounds  
The invention provides a compound of formula I: wherein X, Y, Z have any of the values defined in the specification or a salt thereof. The compound is useful as anti-cancer agents. The invention...
US20180093088 CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
9924867 Automated determination of arteriovenous ratio in images of blood vessels  
The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates....
US20180066081 SUBSTITUTED CYCLIC ETHER POLYMERS AND CONJUGATES AND USES THEREOF  
Disclosed herein are substituted cyclic ether monomers, polymers, and drug conjugates thereof, which are useful for the treatment of diseases and conditions of the oral cavity. In particular,...
US20180055920 VACCINE, THERAPEUTIC COMPOSITION AND METHODS FOR TREATING OR INHIBITING CANCER  
The present invention provides a method of preparing an anti-cancer composition comprising activated immune cells and a pharmaceutically acceptable excipient. The present invention further...
9902713 Neuroprotective compounds and use thereof  
Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic brain injury. An aminopropyl carbazole...
9891301 Apparatus and methods for dynamical tracking of mechanical activity within cell populations  
Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.
9884052 Compounds and methods to treat organophosphorus poisoning  
Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a...
9865660 Organic magnetoelectroluminescence for transduction between magnetic and optical information  
An optoelectronic device which can read magnetically stored information, and convert it into optical light signals using organic or “plastic” semiconductors is described. Such a device may use...
9861802 Catheters, catheter systems, and methods for puncturing through a tissue structure  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
US20180002295 Compositions and Methods for Treating Anxiety and Compulsive Behavior  
Provided herein is compositions and methods for treating anxiety, obsession and/or pathologically compulsive behavior associated with various neuropsychiatric diseases.
US20180000925 VIRAL RNA SEGMENTS AS IMMUNOMODULATORY AGENTS AND VACCINE COMPONENTS  
The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In...
US20180000907 METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES  
The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1...
US20180000736 METHODS FOR THE REGENERATION OF ARTICULAR CARTILAGE IN VIVO  
A pharmaceutical composition is provided that is useful to enhance the repair of articular cartilage, to treat a joint injury or to prevent, inhibit or treat osteoarthritis in a mammal. The...
9856204 Methods for inhibiting muscle atrophy  
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a...
9855332 Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels  
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and...
US20170369877 REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY  
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
US20170369543 METHODS AND REAGENTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION  
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of...
9849195 Methods and compositions for treating brain diseases  
The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing...
US20170357038 Miniature Grism System for Astronomical Spectroscopy  
The invention is directed at a miniature grism system. The miniature grism system is a single compact device that comprises a grism with collimating and focusing optics. In an aspect, the grism...
US20170356045 GENES AND POLYMORPHISMS ASSOCIATED WITH AMD  
There is provided a method of screening for susceptibility to complement dysregulation in an individual, the method including screening for the presence or absence of a genetic profile...
US20170348386 METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES  
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.
9834791 CRISPR-related methods and compositions with governing gRNAS  
Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9...
US20170342141 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS  
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia,...
9828587 Chimeric adeno-associated virus/ bocavirus parvovirus vector  
The invention provides an isolated chimeric virus comprising bocavirus capsid protein, e.g., an isolated chimeric virus comprising human bocavirus capsid protein, and a recombinant...
US20170336395 METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS  
The present disclosure provides methods of determining A-beta in a mammal before and after treatment of an amyloid disorder, comprising obtaining a first blood sample from the mammal;...
US20170335318 RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF  
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
US20170333896 FLUID HANDLING SYSTEMS FOR APPLICATION OF FLUID SHEAR STRESS TO A FLUID SAMPLE  
A fluid handling system for applying a plurality of pulses of fluid shear stress to a fluid sample may comprise a first sample chamber; a second sample chamber; a plurality of conduits mounted...
9820651 Methods and devices for labeling and/or matching  
Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of...
US20170326075 THYMOL AND CARVACOL FOR USE IN MEDICINE  
The invention provides therapeutic methods comprising the administration of thymol or carvacrol, or a pharmaceutically acceptable salt or prodrug thereof. The methods are useful for modulating...
US20170321190 METHODS TO GENERATE EPITHELIAL CELLS  
The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with...
US20170315130 EARLY PREDICTION OF PREECLAMPSIA  
The invention relates to methods and kits for diagnosing or predicting the likelihood of occurrence of preeclampsia in a subject with no history of the disease.
US20170314020 MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION  
In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention...