Patents and Patent Applications from University of Iowa


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9891301 Apparatus and methods for dynamical tracking of mechanical activity within cell populations  
Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.
9884052 Compounds and methods to treat organophosphorus poisoning  
Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a...
9865660 Organic magnetoelectroluminescence for transduction between magnetic and optical information  
An optoelectronic device which can read magnetically stored information, and convert it into optical light signals using organic or “plastic” semiconductors is described. Such a device may use...
9861802 Catheters, catheter systems, and methods for puncturing through a tissue structure  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
US20180002295 Compositions and Methods for Treating Anxiety and Compulsive Behavior  
Provided herein is compositions and methods for treating anxiety, obsession and/or pathologically compulsive behavior associated with various neuropsychiatric diseases.
US20180000925 VIRAL RNA SEGMENTS AS IMMUNOMODULATORY AGENTS AND VACCINE COMPONENTS  
The disclosure provides compositions and methods involving viral RNA segments for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation. In...
US20180000907 METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES  
The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1...
US20180000736 METHODS FOR THE REGENERATION OF ARTICULAR CARTILAGE IN VIVO  
A pharmaceutical composition is provided that is useful to enhance the repair of articular cartilage, to treat a joint injury or to prevent, inhibit or treat osteoarthritis in a mammal. The...
9856204 Methods for inhibiting muscle atrophy  
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a...
9855332 Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels  
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and...
US20170369877 REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY  
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
US20170369543 METHODS AND REAGENTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION  
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of...
9849195 Methods and compositions for treating brain diseases  
The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing...
US20170357038 Miniature Grism System for Astronomical Spectroscopy  
The invention is directed at a miniature grism system. The miniature grism system is a single compact device that comprises a grism with collimating and focusing optics. In an aspect, the grism...
US20170356045 GENES AND POLYMORPHISMS ASSOCIATED WITH AMD  
There is provided a method of screening for susceptibility to complement dysregulation in an individual, the method including screening for the presence or absence of a genetic profile...
US20170348386 METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES  
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.
9834791 CRISPR-related methods and compositions with governing gRNAS  
Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9...
US20170342141 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS  
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia,...
9828587 Chimeric adeno-associated virus/ bocavirus parvovirus vector  
The invention provides an isolated chimeric virus comprising bocavirus capsid protein, e.g., an isolated chimeric virus comprising human bocavirus capsid protein, and a recombinant...
US20170336395 METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS  
The present disclosure provides methods of determining A-beta in a mammal before and after treatment of an amyloid disorder, comprising obtaining a first blood sample from the mammal;...
US20170335318 RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF  
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
US20170333896 FLUID HANDLING SYSTEMS FOR APPLICATION OF FLUID SHEAR STRESS TO A FLUID SAMPLE  
A fluid handling system for applying a plurality of pulses of fluid shear stress to a fluid sample may comprise a first sample chamber; a second sample chamber; a plurality of conduits mounted...
9820651 Methods and devices for labeling and/or matching  
Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of...
US20170326075 THYMOL AND CARVACOL FOR USE IN MEDICINE  
The invention provides therapeutic methods comprising the administration of thymol or carvacrol, or a pharmaceutically acceptable salt or prodrug thereof. The methods are useful for modulating...
US20170321190 METHODS TO GENERATE EPITHELIAL CELLS  
The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with...
US20170315130 EARLY PREDICTION OF PREECLAMPSIA  
The invention relates to methods and kits for diagnosing or predicting the likelihood of occurrence of preeclampsia in a subject with no history of the disease.
US20170314020 MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION  
In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention...
US20170311569 GENTLE ANIMAL COLLAR FOR USE WITH ALERT AND PREVIOUSLY CANNULATED ANIMALS, AND ASSOCIATED SYSTEMS AND METHODS  
The disclosed apparatus, systems and methods relate to various devices, systems and methods for gently restraining an unanesthetized laboratory animal, particularly for facial recognition...
9806710 Voltage-controlled magnetic-based devices having topological insulator/magnetic insulator heterostructure  
A voltage-controlled magnetic based device is described that includes a magnetic insulator; a topological insulator adjacent the magnetic insulator; and magnetic dopants within the topological...
9801922 Compositions and methods of treating cancer  
The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a...
US20170306355 MODIFIED ADENO-ASSOCIATED VIRUS VECTOR COMPOSITIONS  
An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
US20170306326 MICRORNA INHIBITOR SYSTEM AND METHODS OF USE THEREOF  
The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
US20170304304 THERAPEUTIC COMPOUNDS  
The invention provides a compound of formula I: wherein X, Y, Z have any of the values defined in the specification or a salt thereof. The compound is useful as anti-cancer agents. The invention...
US20170290929 GRP78 TARGETED CONJUGATES  
Accordingly, certain embodiments of the invention provide a conjugate of formula (I): P-(X-D)n, wherein P is a peptide that binds to a glucose regulated protein 78 (GRP78); X is a direct bond or a...
US20170288666 VOLTAGE-CONTROLLED MAGNETIC-BASED DEVICES HAVING TOPOLOGICAL INSULATOR/MAGNETIC INSULATOR HETEROSTRUCTURE  
A voltage-controlled magnetic based device is described that includes a magnetic insulator; a topological insulator adjacent the magnetic insulator; and magnetic dopants within the topological...
9776017 Method and system for dynamically-trimmed spot scanning for ion therapy  
A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.
US20170273794 CRANIOPLASTY PLATE  
A cranial plate is provided for use after a craniectomy. The plate is mounted to the skull and protects the brain exposed in the skull opening. A plate is initially spaced above the skull with...
US20170260285 METHODS FOR TREATING CANCER  
The present invention relates to pharmaceutical compositions and methods of treating cancer in a subject, the method comprising administering to the subject a combination therapy comprising...
US20170258058 TRANSGENIC PIG MODELS OF CYSTIC FIBROSIS  
This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.
9758781 Methods to prevent and treat autosomal dominant non-syndromic hearing loss  
The present invention provides in certain embodiments a method of treating autosomal dominant non-syndromic hearing loss (ADNSHL) in a patient in need thereof comprising: (a) identifying a...
9750516 Positioning device for ankle joint replacement surgery  
A positioning device for ankle joint replacement surgery.
9745331 Therapeutic bisphosphonates  
The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods...
US20170240966 PREDICTING AMD WITH SNPS WITHIN OR NEAR C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715  
The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of a complement cascade dysregulation disease such as AMD. The invention provides...
US20170240864 METHODS TO GENERATE PANCREATIC BETA CELLS FROM SKIN CELLS  
In certain embodiments, the present invention provides methods to prepare insulin secreting cells from a skin sample from a mammal.
US20170239491 REAL-TIME APPLICATION POSITION MONITORING SYSTEM  
A real-time applicator position monitoring system (RAPS) measures brachytherapy applicator displacement in real-time by computing the relative displacement between two infrared reflective targets,...
US20170236282 AUTOMATED ASSESSMENT OF GLAUCOMA LOSS FROM OPTICAL COHERENCE TOMOGRAPHY  
Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional...
9730988 Parasitic biological agents for treatment and prevention of graft versus host disease  
The invention relates to helminthic parasite preparations and their use for treatment or prevention of GVHD in a subject that has undergone a transplant. The invention also related to helminthic...
US20170226512 NUCLEIC ACID APTAMERS  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20170225967 Use of Magnetic Mesoporous Silica Nanoparticles For Removing Uranium From Media  
The present invention is directed to a method of removing uranium from a uranium containing aqueous medium. The method comprises a step of contacting the medium with magnetic mesoporous silica...
US20170224847 OLIGONUCLEOTIDE-BASED PROBES FOR DETECTION OF BACTERIAL NUCLEASES  
The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful...