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US20120108514 |
LONG ACTING ATRIAL NATRIURETIC PEPTIDE (LA-ANP) AND METHODS FOR USE THEREOF
Materials and Methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus.
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US20120095089 |
SCHWEINFURTHINS AND USES THEREOF
Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient...
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8158592 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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US20120088148 |
MAGNETIZED BATTERY CATHODES
The present invention provides a magnetized cathode mixture material comprising a ferromagnetic material, an electroactive material, and an electrolyte.
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8155403 |
Methods and devices for airway tree labeling and/or matching
Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of...
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8148340 |
Immunomodulatory oligonucleotides
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies...
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US20120071356 |
Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration
Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk...
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US20120069299 |
HYBRID LASER OPHTHALMOSCOPE
Provided is a hybrid laser ophthalmoscope comprising a laser light source, a LED light source, and a holographic diffuser, wherein the holographic diffuser is configured to shape a beam of light...
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8137682 |
Isolated complexes of covalently cross-linked endotoxin and modified MD-2
Applicants have produced and isolated chemically cross-linked complexes of endotoxin and modified MD-2, and have developed methods of using these complexes.
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8129351 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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8129161 |
Bardet-Biedl susceptibility gene and uses thereof
The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such...
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8126564 |
Hybrid cochlear implant
An electrode array which is able to be inserted to a desired depth within the cochlea to provide useful percepts for the recipient which will also preferably not cause damage to the sensitive...
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8124518 |
Semiconductor heterostructure nanowire devices
Nanowire devices comprising core-shell or segmented nanowires are provided. In these nanowire devices, strain can be used as a tool to form metallic portions in nanowires made from compound...
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8119766 |
Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration
Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to...
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US20120040884 |
Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration
Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for...
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8114848 |
Immunomodulatory oligonucleotides
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies...
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US20120035320 |
POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES
The present invention provides nucleic acid delivery polyplex complexes and anionic open polyplexes comprising a nucleic acid molecule reversibly bound to one or more of nucleic acid delivery...
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US20120027673 |
SYNTHESIS OF HIERARCHICAL NANOCRYSTALLINE ZEOLITES WITH CONTROLLED PARTICLE SIZE AND MESOPOROSITY
A one step synthesis of nanocrystalline zeolites ZSM-5 and Naβ from a single template system in high yield has been discovered. The size of individual nanocrystals, as well as mesopore surface ...
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US20120015396 |
COMPOSITIONS AND METHODS FOR MODULATING THE ACID-SENSING ION CHANNEL (ASIC)
Novel compositions for modulating acid-sensing ion channels (ASIC) function comprising ASICα, ASICβ, and BNC1 and derivatives thereof; methods for modulating ASIC function and methods for t...
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US20120014875 |
NUCLEIC ACID APTAMERS
The present invention relates to optimized aptamers and methods of using these aptamers.
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8090431 |
Systems and methods for bioluminescent computed tomographic reconstruction
An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first...
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8088579 |
Complement factor H for diagnosis of age-related macular degeneration
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of...
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8088396 |
Isolated complexes of endotoxin and modified MD-2
Applicants have produced and isolated water soluble complexes of endotoxin and modified MD-2.
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US20110319481 |
SCHWEINFURTHIN ANALOGUES
Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer...
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US20110318735 |
REGULATION OF THE SEROTONIN REUPTAKE TRANSPORTER AND DISEASE
Described herein is a CpG island in the 5′ region of the 5HTT gene that contains an alternative exon 1 and promoter for 5HTT. Methylation at this CpG island is associated with decreased levels of 5...
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8080206 |
Multicomponent analysis of volatile organic compositions in vapor samples
Amounts of volatile organic compositions can be evaluated from vapor samples based on the time dependent response of a fuel cell contacted with the vapor sample at its anode. The time response of...
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8077152 |
Magneto resistive elements and methods for manufacture and use of same
The instant disclosure provides and describes a magneto resistive element comprised of a first electrode; a second electrode; and a semi conductive/conductive organic layer disposed between the...
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US20110301580 |
METHODS AND DEVICES FOR ARYTENOID REPOSITIONING
Methods and devices for repositioning the arytenoid cartilage of a human subject are disclosed.
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8058249 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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US20110260278 |
System and Method of Planar Processing of Semiconductors into Detector Arrays
An article of manufacture and a method of defining a photodetector element are provided. The article of manufacture includes a photodector element comprising a junction formed by a first III-V...
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US20110253151 |
POSITIONING DEVICE FOR ANKLE JOINT REPLACEMENT SURGERY
A positioning device for ankle joint replacement surgery.
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US20110251299 |
PHOTO-ENFORCED STRATIFICATION OF POLYMERIC MATERIALS
The invention provides a process for manufacturing a polymeric material having a compositional gradient, comprising: forming a mixture comprising a first photopolymerizable polymer precursor and a...
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US20110244562 |
RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
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US20110244561 |
siRNA-MEDIATED GENE SILENCING
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
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US20110237645 |
USE OF RNAi TECHNOLOGY TO INHIBIT ASIC3
In vitro studies using cells transfected with acid-sensing ion channel 3 (ASIC3) or acid-sensing ion channel 1 (ASIC1) cDNA, demonstrated that the miRNAs against mouse ASIC3 (miR844 and miR847)...
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US20110214997 |
MAGNETICALLY MODIFIED SEMICONDUCTOR ELECTRODES FOR PHOTOVOLTAICS, PHOTOELECTROSYNTHESIS, AND PHOTOCATALYSIS
A device for hydrogen gas production comprising a working electrode comprising a magnetically-modified semiconductor electrode. Onset of hydrogen gas evolution for the device, measured at a current...
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8012683 |
Variants in complement regulatory genes predict age-related macular degeneration
Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk...
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8012466 |
Immunogenic compositions for activating γδ T cells
Disclosed are compositions, kits, and methods for activating, expanding, or stimulating γδ T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical c...
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US20110212576 |
SEMICONDUCTOR HETEROSTRUCTURE NANOWIRE DEVICES
Nanowire devices comprising core-shell or segmented nanowires are provided. In these nanowire devices, strain can be used as a tool to form metallic portions in nanowires made from compound...
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US20110212520 |
RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
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8008266 |
Methods of treating cancer using immunostimulatory oligonucleotides
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
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US20110207190 |
METHODS OF XYLITOL PREPARATION
The invention provides spray-dried preparations of microbes useful for oxidoreductase reactions, e.g., xylitol production, and methods of making and using those microbes.
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US20110206773 |
SUSTAINED DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES
Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and...
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8000798 |
Cochlear implant system substantially preserving the hydrodynamic nature of the cochlea
An electrode array (30) which is able to be inserted to a desired depth within the cochlea to provide useful percepts for the recipient which will also preferably not cause damage to the sensitive...
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7995810 |
System and methods for image segmentation in n-dimensional space
A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods...
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7992422 |
Breath-based sensors for non-invasive molecular detection
A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each...
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7989675 |
Method of identifying compounds using a transgenic pig model of cystic fibrosis
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of...
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US20110182908 |
Diagnostics and Therapeutics for Macular Degeneration-Related Disorders
The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.
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US20110166687 |
METHOD FOR DETERMINING THE PRODUCTION PARAMETERS FOR A SUBSTRATE COATING PROCESS
A method to evaluate, determine and optimize production parameters for a coating application of a UV cationic polymerizable coating system to a substrate is provided. The method is based on a...
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US20110166081 |
Alpha-dystroglycan as a Protein Therapeutic
Disclosed is alpha-dystroglycan protein (alpha-DG) in glycosylated and functional form. The disclosed alpha-DG binds to the basal lamina and to the sarcolemma of muscle fibers and may be injected...
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