Patents and Patent Applications from University of Iowa


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US20170290929 GRP78 TARGETED CONJUGATES  
Accordingly, certain embodiments of the invention provide a conjugate of formula (I): P-(X-D)n, wherein P is a peptide that binds to a glucose regulated protein 78 (GRP78); X is a direct bond or a...
US20170288666 VOLTAGE-CONTROLLED MAGNETIC-BASED DEVICES HAVING TOPOLOGICAL INSULATOR/MAGNETIC INSULATOR HETEROSTRUCTURE  
A voltage-controlled magnetic based device is described that includes a magnetic insulator; a topological insulator adjacent the magnetic insulator; and magnetic dopants within the topological...
9776017 Method and system for dynamically-trimmed spot scanning for ion therapy  
A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.
US20170273794 CRANIOPLASTY PLATE  
A cranial plate is provided for use after a craniectomy. The plate is mounted to the skull and protects the brain exposed in the skull opening. A plate is initially spaced above the skull with...
US20170260285 METHODS FOR TREATING CANCER  
The present invention relates to pharmaceutical compositions and methods of treating cancer in a subject, the method comprising administering to the subject a combination therapy comprising...
US20170258058 TRANSGENIC PIG MODELS OF CYSTIC FIBROSIS  
This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.
9758781 Methods to prevent and treat autosomal dominant non-syndromic hearing loss  
The present invention provides in certain embodiments a method of treating autosomal dominant non-syndromic hearing loss (ADNSHL) in a patient in need thereof comprising: (a) identifying a...
9750516 Positioning device for ankle joint replacement surgery  
A positioning device for ankle joint replacement surgery.
9745331 Therapeutic bisphosphonates  
The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods...
US20170240966 PREDICTING AMD WITH SNPS WITHIN OR NEAR C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715  
The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of a complement cascade dysregulation disease such as AMD. The invention provides...
US20170240864 METHODS TO GENERATE PANCREATIC BETA CELLS FROM SKIN CELLS  
In certain embodiments, the present invention provides methods to prepare insulin secreting cells from a skin sample from a mammal.
US20170239491 REAL-TIME APPLICATION POSITION MONITORING SYSTEM  
A real-time applicator position monitoring system (RAPS) measures brachytherapy applicator displacement in real-time by computing the relative displacement between two infrared reflective targets,...
US20170236282 AUTOMATED ASSESSMENT OF GLAUCOMA LOSS FROM OPTICAL COHERENCE TOMOGRAPHY  
Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional...
9730988 Parasitic biological agents for treatment and prevention of graft versus host disease  
The invention relates to helminthic parasite preparations and their use for treatment or prevention of GVHD in a subject that has undergone a transplant. The invention also related to helminthic...
US20170226512 NUCLEIC ACID APTAMERS  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20170225967 Use of Magnetic Mesoporous Silica Nanoparticles For Removing Uranium From Media  
The present invention is directed to a method of removing uranium from a uranium containing aqueous medium. The method comprises a step of contacting the medium with magnetic mesoporous silica...
US20170224847 OLIGONUCLEOTIDE-BASED PROBES FOR DETECTION OF BACTERIAL NUCLEASES  
The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful...
9724170 Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
US20170216773 METHODS FOR SEPARATING MIXTURES  
This application discloses the method for separating element or isotopes such as protactinium and gallium and isotopes thereof from a corresponding mixture which method comprises contacting the...
9708393 Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers  
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia,...
US20170200399 Precise, Low-Cost Orthopaedic Surgical Simulator  
An orthopaedic surgical simulator includes a bone (a simulated bone or cadaver bone). The simulator further includes a base, wherein the bone is operatively connected to the base, an optical...
US20170173363 CLOSE-PROXIMITY RANGE SHIFTING DEVICE FOR PROTON RADIOSURGERY  
A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS)....
US20170172991 IMAGE GUIDED THERAPY FOR CANCER  
The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.
US20170166924 METHODS FOR PRODUCING AND USING IN VIVO PSEUDOTYPED RETROVIRUSES  
The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines...
US20170165500 ADVANCED ROTATING-SHIELD BRACHYTHERAPY AND PLANNING OF THE SAME  
Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an...
US20170160519 IMAGING LENS, CAMERA MODULE, AND IMAGING APPARATUS  
The present technology relates to an imaging lens, a camera module, and an imaging apparatus that make it possible to obtain an imaging lens that has a small size and excellent optical...
US20170157390 FLOATING ELECTRODES THAT ENGAGE AND ACCOMMODATE MOVEMENT OF THE SPINAL CORD  
This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are...
9669115 Co-crystals and salts of contrast agents and imaging  
The invention provides co-crystals and salts of contrast agents as well as methods to use and prepare the co-crystals and salts.
US20170151029 CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
9661831 Transgenic pig models of cystic fibrosis  
This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.
9650631 Reduction of off-target RNA interference toxicity  
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
9649357 Treatment of chronic nephropathies using soluble complement receptor type I (sCR1)  
A method is disclosed for treating nephropathies involving undesired alternative pathway complement activation by administration of a complement inhibitory protein such as soluble complement...
US20170132382 METHOD FOR DETERMINING PROGRAMMATICALLY EXPECTED DISEASE RECURRENCE LIKELIHOOD  
The disclosure is directed a computer implemented method for determining the likelihood of recurrence of a disease.
9645139 Neuroprotective chemicals and methods for identifying and using same  
Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to...
US20170124815 Methods And Systems For Augmentative And Alternative Communication  
Methods and systems for augmentative and alternative communication are disclosed. An example method can comprise receiving a candidate input, classifying the candidate input as an intentional...
US20170119251 Methods and devices for labeling and/or matching  
Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of...
US20170107173 THERAPEUTIC COMPOUNDS AND METHODS  
Compounds of formula I: and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I,...
9624497 Nucleic acid aptamers  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20170100370 COMPOSITIONS AND METHODS FOR CANCER THERAPY  
The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances...
US20170098311 GRAPH SEARCH USING NON-EUCLIDEAN DEFORMED GRAPH  
Disclosed are methods and systems for analyzing data. An example method can comprise receiving volume data representative of an object. A first graph can be generated based on the volume data. The...
9611301 GB virus C (hepatitis G virus) E2 glycoprotein as an immunomodulatory agent  
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving GBV-C E2 polypeptides and...
9603949 Oligonucleotide-based probes for detection of bacterial nucleases  
The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful...
US20170082717 APPARATUS AND METHODS FOR DYNAMICAL TRACKING OF MECHANICAL ACTIVITY WTHIN CELL POPULATIONS  
Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.
9595171 Methods and systems for augmentative and alternative communication  
Methods and systems for augmentative and alternative communication are disclosed. An example method can comprise receiving a candidate input, classifying the candidate input as an intentional...
US20170065814 ELECTRODE ARRAY CONFIGURED TO WRAP AROUND AND STIMULATE THE SPINAL CORD  
A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver...
US20170065577 THERAPEUTIC COMPOSITIONS AND METHODS  
Therapeutic methods and compositions for treating fibrosis (e.g. scarring) are provided, as well as compositions comprising blebbistatin or a salt thereof and PLGA and nanoparticles comprising...
US20170052182 OPTOELECTRONIC CARTRIDGE FOR CANCER BIOMARKER DETECTION UTILIZING SILICON NANOWIRE ARRAYS  
Provided is a biosensor including a nanowire array. According to an example, the nanowire may include at least 1000 nanowires per cm2, the at least 1000 nanowires per cm2 including individual...
9572976 System that secures an electrode array to the spinal cord for treating back pain  
This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are...
9572894 Biodegradable particulate formulations  
The present invention provides three-component compositions comprising microparticles, a tumor antigen, a first immune adjuvant, and a second immune adjuvant. Also provided are...
US20170031386 Multi-Screen Display System, Devices and Methods  
The disclosed apparatus, systems and methods relate to a collapsible, freestanding display unit. The display unit can be a collapsible and transportable stack system, which may include a base...