Patents and Patent Applications from University of Iowa


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10072264 RNA interference suppression of neurodegenerative diseases and methods of use  
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
10071240 Floating electrodes that engage and accommodate movement of the spinal cord  
This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are...
10059746 Methods of improving vaccine immunogenicity  
The present invention provides a process called “Immune Banking” that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular...
US20180236105 METHODS FOR TREATING NEURODEGENERATIVE DISEASES USING GENE THERAPY TO DELAY DISEASE ONSET AND PROGRESSION WHILE PROVIDING COGNITIVE PROTECTION  
The present disclosure provides methods of treating a lysosomal storage disorder in a mammal which method comprises administering AAV particles encoding a polypeptide directly to the central...
10052304 Compositions and methods for cancer therapy  
The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances...
US20180228806 THERAPEUTIC STRATEGIES FOR THE TREATMENT OF PREECLAMPSIA  
Compositions and methods for treating preeclampsia in a subject in need thereof are disclosed.
10045874 Clubfoot orthotic  
Kits, devices, and methods for treating clubfoot are provided. The devices have two platforms that are attached to a bar. The platforms define slots to allow therapeutically preferred orientations...
US20180224359 METHOD OF PURIFYING TUMOR CELLS USING SHEAR STRESS  
Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a...
US20180221433 ANGIOTENSINS IN MUSCULAR DYSTROPHY  
The present invention provides, among other things, methods of treating a muscular dystrophy including administering to a subject suffering from or susceptible to a muscular dystrophy an...
US20180214690 SYSTEMS AND METHODS FOR CARDIOVASCULAR CONDITIONING  
An example system has a pulse generator configured to deliver a first series of electrical signals to a right atrium of a heart. The first series of electrical signals can increase a first heart...
US20180214402 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.
10035025 Close-proximity range shifting device for proton radiosurgery  
A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS)....
10034936 Method of inducing a cross-reactive HIV-1 immune response by administering a composition comprising the GBV-C E2 protein  
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or...
US20180209956 HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies  
Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized...
US20180207284 FLUORESCENT PRODRUGS  
The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the...
10029118 Advanced rotating-shield brachytherapy and planning of the same  
Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an...
US20180200540 SYSTEM AND METHOD FOR AN INTENSITY MODULATED RADIATION THERAPY DEVICE  
Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape...
US20180200497 CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
US20180200331 BST-2 AS A THERAPEUTIC TARGET AND DIAGNOSTIC MARKER FOR BREAST CANCER GROWTH AND METASTASIS  
Disclosed are compositions, kits, and methods for treating and/or diagnosing cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat and/or diagnose cancers...
10022386 Tomatidine, analogs thereof, compositions comprising same, and uses for same  
In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract...
US20180194824 MUSCLIN PEPTIDES AND METHODS OF USE THEREOF  
In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or preventing or reducing muscle atrophy and...
10006028 Alternative export pathways for vector expressed RNA interference  
The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
10004212 Transgenic pig models of cystic fibrosis  
This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.
US20180169298 PREVENTATIVE THERAPY FOR POST-TRAUMATIC OSTEOARTHRITIS  
Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits...
US20180169269 METHODS OF DELIVERY OF TRANSGENES FOR TREATING BRAIN DISEASES  
The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant...
US20180161434 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO TREAT DIARRHEA IN SUBJECTS WITH DISEASES OR TREATMENTS THAT RESULT IN ELEVATED CGRP LEVELS  
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and...
9987299 Methods of improving RNAi in well-differentiated airway epithelia  
The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by...
US20180147225 USE OF NAD PRECURSORS FOR BREAST ENHANCEMENT  
Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide...
US20180147224 METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT BLOCKADE THERAPY  
Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The...
9980951 Image guided therapy for cancer  
The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.
US20180142259 METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES  
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered...
US20180134746 NUCLEIC ACID APTAMERS TO TREAT HISTONE-INDUCED DISEASE STATES  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20180127783 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS  
Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9...
US20180118657 METHODS FOR INHIBITING MUSCLE ATROPHY  
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a...
US20180110456 Bladder Health Monitoring System and Related Methods and Devices  
The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health. Certain implementations are directed to patients who require daily catheterization....
9951102 Peptide inhibitor of Nox1 NADPH oxidase  
An isolated peptide or fusion having the peptide useful to interfere with the phosphorylation of Nox1, block or inhibit binding of NoxA1 activation domain (AD) to Nox1, and/or prevent or inhibit...
9950165 Method for causing stochastic depolarization in the spinal cord to inhibit transmission of synchronous action potentials  
This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory...
US20180108139 System And Method For N-Dimensional Image Segmentation Using Convolutional Neural Networks  
Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. The image hypervolume can be provided to a...
9943518 Inhibitors of phosphodiesterase type 5A for reducing skeletal muscle fatigue, edema, and damage in a patient having muscle fatigue due to increased age or exercise  
Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize...
9937182 Therapeutic strategies for the treatment of preeclampsia  
Compositions and methods for treating preeclampsia in a subject in need thereof are disclosed.
9937177 Therapeutic compounds  
The invention provides a compound of formula I: wherein X, Y, Z have any of the values defined in the specification or a salt thereof. The compound is useful as anti-cancer agents. The invention...
US20180093088 CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...
9924867 Automated determination of arteriovenous ratio in images of blood vessels  
The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates....
US20180066081 SUBSTITUTED CYCLIC ETHER POLYMERS AND CONJUGATES AND USES THEREOF  
Disclosed herein are substituted cyclic ether monomers, polymers, and drug conjugates thereof, which are useful for the treatment of diseases and conditions of the oral cavity. In particular,...
US20180055920 VACCINE, THERAPEUTIC COMPOSITION AND METHODS FOR TREATING OR INHIBITING CANCER  
The present invention provides a method of preparing an anti-cancer composition comprising activated immune cells and a pharmaceutically acceptable excipient. The present invention further...
9902713 Neuroprotective compounds and use thereof  
Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic brain injury. An aminopropyl carbazole...
9891301 Apparatus and methods for dynamical tracking of mechanical activity within cell populations  
Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.
9884052 Compounds and methods to treat organophosphorus poisoning  
Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a...
9865660 Organic magnetoelectroluminescence for transduction between magnetic and optical information  
An optoelectronic device which can read magnetically stored information, and convert it into optical light signals using organic or “plastic” semiconductors is described. Such a device may use...
9861802 Catheters, catheter systems, and methods for puncturing through a tissue structure  
A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can...