Patents and Patent Applications from University of Connecticut


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US20120122767 LACTOFERRIN-BASED BIOMATERIALS FOR TISSUE REGENERATION AND DRUG DELIVERY  
The invention provides biomatrix compositions comprising cross-linked lactoferrin, either alone or in combination with other organic or inorganic components. Also provided are methods of making and...
8178629 Conjugated polymer fiber, preparation and use thereof  
Described are conjugated polymer fibers and nanofibers, methods of making, and methods of use thereof. The conjugated polymer fibers and nanofibers can be prepared by an electrostatic spinning...
8168671 Synthesis of thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds and their derivatives and use thereof  
Inexpensive and facile methods of preparing fused heterocycles such as thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds, and their derivatives are disclosed. Also disclosed are...
8163953 Compounds for lysosomal modulation and methods of use  
Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are ...
8163520 Nucleic acids encoding a chimeric polypeptide comprising IL-7 and HGF-beta chain and methods of use  
The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide...
US20120095047 Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect...
8155312 Optical data storage device and method  
A device disclosed herein relates to a rotation invariant data storage device comprising, a data storage device with an optically sensible image, encoded data stored within the sensible image, and...
8153116 Use of conditional plasmodium strains lacking an essential gene in malaria vaccination  
The present invention relates to a malaria vaccine for administration to a host, comprising an attenuated malarial parasite with a gene that has been rendered non-functional, wherein the gene, when...
8152848 Structural/biological implant system  
A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need...
US20120083446 NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS  
An albumin-free Factor VIII formulation comprising, 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from...
8150100 System and method for recognition of a three-dimensional target  
A system for recognition of a target three-dimensional object is disclosed. The system may include a photon-counting detector and a three-dimensional integral imaging system. The three-dimensional...
8150033 Optical security system using fourier plane encoding  
A method of encrypting a set of data is disclosed. The method may include encoding a set of data with a first encryption key, and transforming the set of data encoded with the first encryption key....
US20120078585 METHOD AND SYSTEM FOR CONSTRUCTING GEOMETRIC SKELETONS AND MEDIAL ZONES OF RIGID AND NON-RIGID SHAPES  
A method and system for constructing geometric skeletons of rigid and non-rigid shapes are disclosed, including a method of constructing a convexized skeleton (C-skeleton). A method for determining...
8137103 Implant system  
An implant system may comprise implants, abutments, cylinders and a structural framework with a veneer thereon. A prosthesis comprises the structural framework and veneer. The cylinders are...
US20120060767 Progesterone receptor membrane component 1 (PGRMC1) as an indicator of fertility in animals  
Methods of evaluating fertility of an animal based on determination of a PGRMC1 characteristic that correlates with animal fertility. In one embodiment, a sample is obtained from an animal, a...
8133495 Live attenuated antigenically marked classical swine fever virus  
Classical swine fever virus is a world-wide distributed highly-contagious disease affecting swine. The two main strategies for diseases control are prophylactic vaccination and non-vaccination...
8129532 Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use  
Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit...
8128921 Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination  
The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when...
US20120048805 METHOD OF MODIFYING THIN FILM COMPOSITE MEMBRANE SUPPORT STRUCTURES FOR ENGINEERED OSMOSIS APPLICATIONS  
The disclosure provides a method of modifying thin film composite membrane support structures. In particular, the disclosure provides method of modifying thin film composite membrane support...
8124084 Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra  
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention...
8119832 Systems for alkyl ester production  
In one embodiment, an alkyl ester production system can comprise: a first transesterification reactor comprising a liquid biomass inlet located between a liquid glycerol outlet and a liquid alkyl...
US20120040907 Method of Use of Bioactive Materials  
A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin...
8107153 Flexible electrochromic devices, electrodes therefor, and methods of manufacture  
An electrochromic fiber or fabric is disclosed. The fiber or fabric includes a flexible, electrically conductive fiber, and a layer comprising an electrochromic material disposed on and surrounding...
US20120021997 USING HEAT SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC BENEFIT OF A NON-VACCINE TREATMENT MODALITY  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a n...
US20120021996 USING HEAT SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC BENEFIT OF A NON-VACCINE TREATMENT MODALITY  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a n...
PP22465 Buddleja plant named ‘Summer Skies’  
Buddleja davidii ‘Summer Skies’ is a distinct form of butterfly bush that combines several desirable characteristics in a landscape plant including the following: upright and outwardly spr...
US20120015363 Progesterone receptor membrane component 1(PGRMC1) as an indicator of human fertility  
Methods of evaluating fertility of a human based on determination of a PGRMC1 characteristic that correlates with human fertility. In one embodiment, a sample is obtained from a human, a PGRMC1...
8097385 Bipolar plate for fuel cell  
The present disclosure provides for a bipolar plate assembly for use in a fuel cell stack. The bipolar plate assembly includes: (a) at least one flow field layer defining a flow field portion and a...
US20110317240 Flexible Electrochromic Devices, Electrodes Therefor, And Methods of Manufacture  
An electrochromic fiber or fabric is disclosed. The fiber or fabric includes a flexible, electrically conductive fiber, wherein the fiber comprises a non-electrically conductive organic polymer...
US20110315563 SENSORS FOR ANALYTE DETECTION AND METHODS OF MANUFACTURE THEREOF  
Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a...
8084467 Pyrazole derivatives as cannabinoid receptor antagonists  
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or...
8084451 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect...
8084095 Ceramic/structural protein composites and method of preparation thereof  
Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates,...
8080821 Thyristor radiation detector array and applications thereof  
An array of thyristor detector devices is provided having an epitaxial growth structure with complementary types of modulation doped quantum well interfaces located between a P+ layer and an N+...
US20110304404 SIGNAL GENERATORS BASED ON SOLID-LIQUID PHASE SWITCHING  
A phase-change oscillator and pulse generator, and related methods, are provided. The phase-change oscillator and pulse generator can include a capacitor, a switching element coupled in parallel...
8071118 Method of inducing cell proliferation using fibroin  
A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin...
8070682 Method and apparatus for medical imaging using combined near-infrared optical tomography, fluorescent tomography and ultrasound  
Methods and apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography and ultrasound are disclosed. In one embodiment, the probe comprises...
8058515 Plant cells and plants overexpressing vacuolar proton pyrophosphatases  
The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant....
8058226 Albumin-free factor VIII formulations  
A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of...
8029808 Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a n...
US20110217337 BIOACTIVE AGENT FOR BONE TISSUE ENGINEERING  
Inventors have discovered a method for inducing bone formation in a patient in need thereof comprising administering an effective amount of benzoyladenosine-3′,5′-cyclic monophosphate (6-...
8011864 Method for facilitating chatter stability mapping in a simultaneous machining application  
Systems and methods are provided for use in assessing the stability of simultaneous machining (SM) dynamics (which is also known as parallel machining). In SM, multiple cutters, which are generally...
8007854 Ceramic coating and method of preparation thereof  
A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
US20110208190 Natural Polymer-Based Porous Orthopedic Fixation Screw for Bone Repair and Regeneration  
A bone fixation device made of polysaccharide particles or microspheres fused into a solid structure is provided herein. The bone fixation device may be in the form of an orthopedic screw,...
8003852 Transgenic plants overexpressing a plant vacuolar pyrophosphatase  
Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic...
7998690 Methods for the detection and monitoring of congestive heart failure  
Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive...
US20110193277 Smart Vibration Absorber For Traffic Signal Supports  
Disclosed herein is a smart vibration absorber for traffic signal supports. In exemplary embodiments, the vibration absorber utilizes the mass of the signal head as a damped vibration absorber. The...
7989534 Polymer-clay nanocomposites and methods of making the same  
Polymer-clay nanocomposites and methods of making the same are provided. In an embodiment, a polymer-clay nanocomposite comprises a non-metal salt of an ionomer and a nanostructured layered clay....
7981389 Process using microwave energy and a catalyst to crack hydrocarbons  
A process for cracking hydrocarbons at atmospheric pressure includes the following steps: providing a catalyst, passing a gaseous hydrocarbon over the catalyst and exposing the catalyst to...
US20110172753 ENDOPROSTHESES  
Endoprosthesis are disclosed.