Patents and Patent Applications from University of Colorado


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9895420 IL-1beta propeptide and IL-1Ra chimera and methods of using the same  
The present invention provides a chimera protein made of amino acid residues derived from IL-1beta propeptide and the IL-1Ra mature peptide and polynucleotides encoding the protein. The present...
US20180044352 Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase Inhibitors and Methods of Use Thereof  
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts...
US20180043022 NOVEL LIGHT-ACTIVATED COMPOSITIONS AND METHODS USING THE SAME  
The invention includes light-activated compositions and methods that are useful for promoting cell death or growth. In certain embodiments, the compositions comprise quantum dots (QD).
US20180042717 DEVICES AND METHODS FOR STABILIZATION OF AN OCULAR LENS CAPSULE AND PREVENTING ARTIFICIAL INTRAOCULAR LENS IMPLANT ROTATION POST CATARACT SURGERY  
The present invention relates generally to the fields of ophthalmology and cataract surgery. More specifically, the present invention relates to a device implanted in the eye during cataract...
9891584 Coherent diffractive imaging with arbitrary angle of incidence  
Apparatus and methods for coherent diffractive imaging with arbitrary angle of illumination incidence utilize a method of fast remapping of a detected diffraction intensity pattern from a detector...
US20180036173 OCULAR FILTRATION DEVICES, SYSTEMS AND METHODS  
A glaucoma drainage device regulator (GDDR) is disclosed which comprises a membrane and a shunt tube to regulate the flow of aqueous in conjunction with different ocular (e.g., glaucoma) filtering...
US20180036169 NASOLACRIMAL IMPLANTS AND RELATED METHODS FOR TEAR STIMULATION  
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also...
9887627 Low profile power conversion system for rooftop photovoltaic power systems  
The disclosed embodiments and principles provide a way to integrate high-efficiency, low-profile power electronics with localized maximum power point tracking (MPPT) into a rooftop shingle-based...
9885018 High efficiency reprogramming of fibroblasts into cardiomyocytes  
Pro-fibrotic signaling potently antagonizes cardiac reprogramming. Inhibition of pro-fibrotic signaling using small molecules that target the transforming growth factor-β/SMAD, or Rho kinase leads...
9884941 Systems and methods of creating liquid crystal polymers using stepped reactions  
Provided herein are systems and methods for polymerizing and programming a liquid crystal polymer, including a liquid crystal elastomer (LCE) with two-way shape-memory via a stepped or...
9884096 Compositions and methods related to graft versus host disease and treatments thereof  
Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In particular, the present invention relates to...
US20180028133 AUTOMATED TRACKING OF FIDUCIAL MARKER CLUSTERS IN X-RAY IMAGES  
Various embodiments of the present technology generally relate to identification of tumor location. More specifically, some embodiments of the present technology relate automated tracking of...
9881355 Three-dimensional single-molecule fluorescence imaging beyond the diffraction limit using a double-helix point spread function  
Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a...
9879012 Click nucleic acids  
Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click...
9877825 Modular intraocular lens designs and methods  
A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the...
9877772 Electrosurgical generator controller for regulation of electrosurgical generator output power  
An electrosurgical generator may reduce unintended tissue damage by improving regulation of output power. The electrosurgical generator may control the power during a cycle, and react to a change...
US20180026899 METHOD AND APPARATUS FOR CONTROLLING SEND BUFFER OF TRANSMISSION CONTROL PROTOCOL IN COMMUNICATION SYSTEM  
Methods and apparatuses for controlling transmission control protocol (TCP) send buffers in communication systems are provided. The method includes identifying a current round-trip time (RTT)...
US20180026540 MODULAR DC-DC CONVERTER  
A modular dc-dc boost converter system is provided that can substantially improve efficiency over a wide range of input and output voltages. The system includes three modules: a buck module, a...
US20180024153 DISEASE SEVERITY INDEX FOR ASSESSMENT OF CHRONIC LIVER DISEASE  
A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function...
US20180023599 PHONONIC MATERIALS USED TO CONTROL TURBULENT FLOW  
A phononic material and a method of using a phononic material for use in interacting with a fluid or solid flow are provided. The phononic material includes an interface surface and a subsurface...
US20180021171 NASOLACRIMAL IMPLANTS AND RELATED METHODS FOR TEAR STIMULATION  
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also...
9873115 Nanostructured photocatalysts and doped wide-bandgap semiconductors  
Photocatalysts for reduction of carbon dioxide and water are provided that can be tuned to produce certain reaction products, including hydrogen, alcohol, aldehyde, and/or hydrocarbon products....
9872799 Intraocular device for dual incisions  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
US20180014928 MODULAR INTRAOCULAR LENS DESIGNS AND METHODS  
A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the...
US20180011116 Use of Viscoelastic Analysis for Predicting Massive Hemorrhage  
The invention provides methods for identifying a patient as likely to have an onset of massive hemorrhage. In one embodiment, the invention provides a method for identifying a patient as likely to...
US20180008662 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING PULMONARY HYPERTENSION  
The present invention provides a method of treating and/or preventing pulmonary hypertension in a subject in need thereof, the method comprising administering to the subject a therapeutically...
US20180002692 Sequence Specific and Organism Specific Antimicrobials and Related Materials and Methods  
Described herein are RNA-based antisense therapeutics to target antibiotic resistant bacteria. The antisense therapeutics disclosed herein can be useful in re-sensitizing drug-resistant bacteria...
9858464 3-D localization and imaging of dense arrays of particles  
Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging...
US20170373662 MULTISTAGE MATCHING NETWORK AND RELATED TECHNIQUES  
Multistage matching networks and analytical frameworks for improving and/or optimizingthe networks is provided. In one example, a framework relaxes the resistive constraint on the input and load...
US20170373660 Matching networks for wireless power transfer and related techniques  
In one implementation, an analytical approach to determining an improved and/or optimal design of a matching network in a capacitive or inductive WPT system is provided. In one implementation, for...
US20170373585 HYBRID FEEDFORWARD CONTROL ARCHITECTURE AND RELATED TECHNIQUES  
A systematic procedure for the synthesis of hybrid feedforward control architectures for pulse-width modulated (PWM) switching converters is provided. In this hybrid feedforward control...
US20170369870 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES  
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are...
US20170368136 COMPOSITIONS AND METHODS FOR CaMKII INHIBITORS AND USES THEREOF  
Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further...
US20170367890 INTRAOCULAR DEVICE FOR DUAL INCISIONS  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
US20170366208 Ultrawideband Co-polarized Simultaneous Transmit and Receive Aperture (STAR)  
In various implementations, designs of relatively simple ultra-wideband STAR front-end systems are provided. For example, such systems may include implementations utilizing a plurality of antenna...
US20170365478 NOVEL METHODS OF ATOMIC LAYER ETCHING (ALE) USING SEQUENTIAL, SELF-LIMITING THERMAL REACTIONS  
The invention includes a method of promoting atomic layer etching (ALE) of a surface. In certain embodiments, the method comprises sequential reactions with a metal precursor and a...
US20170362255 LIGAND-EXCHANGEABLE NANOPARTICLES AND METHODS OF MAKING THE SAME  
An aspect of the present disclosure is a nanocrystal that includes a nanocrystal core and a ligand coordinated to a surface of the nanocrystal core, where the ligand includes a functionalized...
US20170360725 FKBP52-SPECIFIC ANDROGEN RECEPTOR INHIBITOR, MJC13, FOR USE IN TREATING BREAST CANCER  
Embodiments of the current invention include methods and compositions for treating breast cancer by administering an effective amount of MJC13 to a subject in need thereof.
9845415 Water compatible nanogel compositions  
The present invention relates to preparation and use of water dispersible nanogels and solvent dispersible reactive nanogels as additives to enhance polymer properties or as precursors to...
US20170356827 Apparatus, Method, and System for Filter Based Cell Capture and Labeling with Configurable Laydown Area  
Devices and methods for labeling and mounting suspended cells in a controllable area are disclosed. The devices and methods utilize polycarbonate filters. The filters are employed both to capture...
US20170355747 PEPTIDES FOR MODULATING T-CELL ACTIVITY AND USES THEROF  
The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the discovery that small peptides are capable...
9840520 Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof  
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts...
US20170348377 COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING  
The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the...
US20170342316 NANOPARTICLES FOR PHOTOVOLTAIC AND LED DEVICES AND METHODS OF MAKING THE SAME  
The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively,...
US20170340208 MICROWAVE THERMOMETER FOR INTERNAL BODY TEMPERATURE RETRIEVAL  
Systems and methods are described for microwave-frequency, passive sensing of internal body temperature. Some implementations include one or more wearable sensors that wirelessly transmit...
9828393 Silylalkyloxyaryl compounds and methods for treating cancer  
Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma,...
US20170338474 STABLE SILICON-IONIC LIQUID INTERFACE LITHIUM-ION BATTERIES  
The disclosure includes a composition of matter including a film formed on substantially all nSi-cPAN particles included in an electrode, the film including fluorine, oxygen, sulfur, carbon and...
US20170338009 SUPERCONDUCTING CABLES AND METHODS OF MAKING THE SAME  
A bundle of superconducting cables employs a plurality of superconducting cables, each having a former and a plurality of superconducting tape conductors wound in at least one layer around the...
US20170336423 Identification of Novel Disease States Using Viscoelastic Analysis in the Presence of an Thrombolytic Agent  
In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic...
9820957 Methods of treating autoimmunity  
Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides...