Patents and Patent Applications from University of Colorado


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9840520 Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof  
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts...
US20170348377 COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING  
The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the...
US20170342316 NANOPARTICLES FOR PHOTOVOLTAIC AND LED DEVICES AND METHODS OF MAKING THE SAME  
The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively,...
US20170340208 MICROWAVE THERMOMETER FOR INTERNAL BODY TEMPERATURE RETRIEVAL  
Systems and methods are described for microwave-frequency, passive sensing of internal body temperature. Some implementations include one or more wearable sensors that wirelessly transmit...
9828393 Silylalkyloxyaryl compounds and methods for treating cancer  
Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma,...
US20170338474 STABLE SILICON-IONIC LIQUID INTERFACE LITHIUM-ION BATTERIES  
The disclosure includes a composition of matter including a film formed on substantially all nSi-cPAN particles included in an electrode, the film including fluorine, oxygen, sulfur, carbon and...
US20170338009 SUPERCONDUCTING CABLES AND METHODS OF MAKING THE SAME  
A bundle of superconducting cables employs a plurality of superconducting cables, each having a former and a plurality of superconducting tape conductors wound in at least one layer around the...
US20170336423 Identification of Novel Disease States Using Viscoelastic Analysis in the Presence of an Thrombolytic Agent  
In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic...
9820957 Methods of treating autoimmunity  
Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides...
9820951 Pulmonary disease treatment and diagnosis based on Arhgef1  
Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease, Arhgef1, a leukocyte signaling molecule, functions normally to suppress...
9820842 Medical fabric with integrated shape memory polymer  
Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP integrated fabric can be fabricated in varying...
US20170332179 THERMAL AND THERMOACOUSTIC NANODEVICES AND METHODS OF MAKING AND USING SAME  
In one aspect, the present invention provides nano-scale heaters, such as nano-scale thermoacoustic loudspeakers comprising suspended metal nanobridges prepared using atomic layer deposition...
US20170331148 LITHIUM ALL-SOLID-STATE BATTERY  
An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a...
US20170326224 HUMAN PAPILLOMA VIRUS CONSTRUCTS  
Embodiments of the present invention provide compositions and methods for recombinantly generating tagless constructs of proteins or peptides. In certain embodiments, recombinant proteins or...
9815890 Antibodies to the C3d fragment of complement component 3  
The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP),...
9815032 Mixed matrix polymer compositions  
The present invention relates to a mixed-matrix composition comprising polymer having a fractional free volume of at least 0.1 and porous particles.
9814448 Three-dimensional optical imaging and therapy of prostate cancer  
A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. An optical probe array has at least two or more optical probes for...
US20170321226 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
US20170321016 LINKERS FOR PROTEIN INTERACTION PROFILING AND METHODS OF MAKING AND USING THE SAME  
Crosslinking compounds for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins, peptides and nucleic acids.
US20170319820 VENOUS ACCESS CATHETERS AND METHODS FOR PORTAL VENOUS SYSTEM CATHETERIZATION  
The present invention contemplates devices and methods to administer nutritional compositions and/or therapeutic drugs directly into a portal venous system. For example, total parenteral nutrition...
US20170319332 INTRAOCULAR LENS DESIGNS FOR IMPROVED STABILITY  
Intraocular lenses (IOLs) that improve lens stability by, for example, increasing anterior-posterior stiffness of the IOL, increasing anterior-posterior dimensions of the IOL and/or increasing...
9808252 Vascular occlusion devices  
Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical...
US20170315421 CMOS Compatible Optical Modulators  
Ring modulators based on interdigitated junctions may be driven in full or partial standing wave mode and, active regions (providing the modulation) and light-absorptive regions (e.g. providing...
US20170303799 Hemodynamic Reserve Monitor and Hemodialysis Control  
Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's...
9796961 Conditionally immortalized long-term stem cells and methods of making and using such cells  
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of...
US20170297206 MEASURING DISTANCE AND CONTACT FORCE DURING ROBOTIC MANIPULATION  
A force, distance and contact measurement system comprising at least one low-cost tactile sensor embedded in elastomer and retrofitted onto existing robotic grippers is provided. The sensor is...
9788938 Intraocular manipulator and related methods  
In accordance with various embodiments, an intraocular manipulator is disclosed which uses negative pressure to grasp and/or manipulate an intraocular object, for example, an IOL, a crystalline...
US20170292073 COMPOSITIONS COMPRISING ANISOTROPIC NANOPARTICLE LIQUID CRYSTAL DISPERSIONS HAVING TUNABLE OPTICAL PROPERTIES  
Disclosed herein are compositions, comprising one or more types of surface modified anisotropic nanoparticles dispersed in a liquid crystal. The compositions provide tunable methods for modifying...
US20170290930 Light-Emitting Versions of the Monoclonal Antibody to C3D (MAB 3D29) for Imaging  
The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for...
9787051 Compact optical frequency comb systems  
Compact optical frequency sources are described. The comb source may include an intra-cavity optical element having a multi-material integrated structure with an electrically controllable active...
US20170281754 Compositions and Methods for Enhanced Innate Immunity  
The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9...
US20170281020 Rapid Detection of Bleeding Following Injury  
Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patient is bleeding, in some cases, noninvasively. In various embodiments, tools and...
9778152 Cell collecting apparatus and method of use  
The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device 100 that is operated by...
9775876 Compositions and methods for CaMKII inhibitors and uses thereof  
Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further...
US20170279147 MODULAR BIOELECTROCHEMICAL SYSTEMS AND METHODS  
Bioelectrochemical systems (BES) having configurations with spiral wound structures and with frame-and-plate structures are provided. Systems may allow for production of an electrical current that...
US20170273927 METHODS OF TREATING AUTOIMMUNITY  
Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides...
US20170269297 Method and Apparatus for Optical Waveguide-to-Semiconductor Coupling for Integrated Photonic Circuits  
A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated...
US20170269088 TARGETING BREAST CANCER THERAPY BASED ON STROMAL SUBTYPES AND CD146 COMPOSITION  
Methods for targeted breast cancer therapy in a subject based upon evaluating the stromal subtypes and CD146 composition in the adjacent tissue. ER+ breast cancers contain two CAF subtypes defined...
US20170265851 OCULAR TISSUE EXPANSION RING  
The present disclosure relates to a structure used in an ophthalmic surgical procedure. The device may be used in pupil expansion or stabilization of the iris. The device is made out of an elastic...
9767940 Superconducting cables and methods of making the same  
Superconducting cables employ one or more superconducting tapes wound around a former. A compact superconducting cable is configured using a former having a small diameter, e.g., less than 10...
US20170260589 POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME  
Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment...
9759731 Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis  
A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function...
9758597 Reducing polymerization-induced shrinkage stress by reversible addition-fragmentation chain transfer  
The invention provides methods of reducing shrinkage stress in cross-linked polymerized materials by combining an addition-fragmentation chain transfer additive with a resin system prior to...
9757279 Intraocular device for dual incisions  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
9757041 Hemodynamic reserve monitor and hemodialysis control  
Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's...
US20170255003 Electrowetting-Actuated Optical Shutters  
Electrowetting-actuated optical shutters based on total internal reflection or beam steering. An electrowetting cell contains a conducting liquid and a non-conducting liquid configured to form a...
US20170254807 Method For Detecting And Purifying Pancreatic Beta Cells  
The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells. Thus, in one aspect, the...
US20170253865 Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof  
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the...
US20170248381 RADIATIVE COOLING STRUCTURES AND SYSTEMS  
Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative...
US20170247767 Biomarkers For Head And Neck Cancer And Methods Of Their Use  
Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell...