Patents and Patent Applications from University of Colorado


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10080648 Modular intraocular lens designs, tools and methods  
Modular IOL removal systems and methods that cut an optic portion of an intraocular in a single motion such to facilitate removal of the optic portion from an eye through an incision, for example...
10080376 Method for enhancing postprocessing content of beneficial compounds in beverages naturally containing same  
A process for enhancing polyphenolics content of beverages brewed from polyphenolic containing, processed beverage substrate by pre-soaking substrate (coffee beans, for example) before roasting...
US20180268185 3-D Localization And Imaging of Dense Arrays of Particles  
Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging...
10076520 Use of tyrosine kinase inhibitor in cancer treatment  
The present invention provides methods for reducing apoptosis of non-cancerous cells during a cancer treatment and beneficial effects associated with reducing such apoptosis. In particular,...
US20180258485 Boranephosphonate Detection Probes and Methods For Producing and Using the Same  
The present invention provides a detection probe and a method for using and producing the same. The detection probe of the invention comprises boranephosphonate moiety and a target selective...
US20180258421 COMPOSITIONS, METHODS AND USES FOR MULTIPLEX PROTEIN SEQUENCE ACTIVITY RELATIONSHIP MAPPING  
Embodiments herein concern systems, compositions, methods and uses for in vivo selection of optimum target proteins of use in designing genomically-engineered cells or organisms. Some embodiments...
US20180255289 3D IMAGING, RANGING, AND/OR TRACKING USING ACTIVE ILLUMINATION AND POINT SPREAD FUNCTION ENGINEERING  
Imaging systems and imaging methods are disclosed to estimate a three-dimensional position of an object at a scene and/or generate a three-dimensional image of the scene. The imaging system may...
US20180250416 COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES  
Embodiments herein report compositions of and methods for making and using alpha-1 antitrypsin (AAT) fusion molecules or peptide derivatives thereof. In certain embodiments, compositions and...
US20180243025 Operating Room Fire Prevention and Electrocautery Safety Device  
This invention is in the field of surgical tools for the prevention of operating room fires. The invention relates to a system and methods which minimizes the threat to the health and safety of...
US20180237608 CELLULOS-ENABLED ORIENTATIONALLY ORDERED FLEXIBLE GELS  
Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable...
US20180237550 COMPOSITIONS AND METHODS OF PROMOTING ORGANIC PHOTOCATALYSIS  
The invention provides novel compounds and methods that are useful in promoting reactions that proceed through an oxidative quenching pathway. In certain embodiments, the reactions comprise atom...
US20180237458 MELAMPOMAGNOLIDE B DIMERS  
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating...
10052393 Multifunctional nanomaterials for the treatment of cancer  
The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared...
US20180230493 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
US20180230492 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
US20180230461 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES  
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are...
US20180230460 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES  
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are...
US20180230459 MULTIPLEXED BINARY ASSEMBLY AND QUANTITATIVE TRACKING OF BACTERIAL POPULATIONS  
Compositions and methods for tracking combinations of mutations in populations by coupling DNA assembly and paired-end sequencing technology with high-throughput sequencing. This allows for an...
10046036 Chemically modified cystathionine β-synthase enzyme for treatment of homocystinuria  
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related...
US20180223437 ATOMIC LAYER ETCHING PROCESSES USING SEQUENTIAL, SELF-LIMITING THERMAL REACTIONS COMPRISING OXIDATION AND FLUORINATION  
The invention includes a method of promoting atomic layer etching (ALE) of a surface. In certain embodiments, the method comprises contacting a solid substrate comprising a first metal compound...
US20180221515 FORMULATION OF ACOUSTICALLY ACTIVATABLE PARTICLES HAVING LOW VAPORIZATION ENERGY AND METHODS FOR USING SAME  
Acoustically activatable particles having low vaporization energy and methods for making and using same are disclosed. A particle of material includes a first substance that includes at least one...
US20180219374 SYSTEMS AND METHODS USING DECISION ANALYSIS FOR CONTROLLING ENERGY CONSUMPTION AND FACILITATING BUILDING PARTICIPATION IN ANCILLARY ENERGY MARKETS  
Building energy consumption is controlled by operating energy consumptive devices according to a control plan determined by: using a software building model to simulate building behavior over a...
US20180215613 METHODS OF ACHIEVING UNIVERSAL INTERFACING USING SUSPENDED AND/OR FREESTANDING STRUCTURES  
The invention includes a method of promoting interfacial mechanical bonding of two or more components through the use of suspended and/or freestanding structures fabricated using an atom-scale...
10036735 Imaging through scattering media with high signal to noise ratio and resolution  
Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Some embodiments can increase the optical fluence in an...
US20180208728 NANOPOROUS LYOTROPIC LIQUID CRYSTAL POLYMER MEMBRANES WITH REVERSIBLY TUNED PORE SIZE AND SELECTIVITY, AND METHODS USING SAME  
The invention includes methods of reversibly tuning the effective pore size and/or solute rejection selectivity of a nanoporous lyotropic liquid crystal (LLC) polymer membrane. The membranes of...
US20180208681 COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES  
Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct...
10028836 System and method of osteodistraction  
Systems, devices, and methods for osteodistraction are provided. The systems and devices comprise ellipsoidal cams for providing controlled distraction of adjacent bone structures using a...
10028824 Modular intraocular lens designs, tools and methods  
Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base...
US20180205348 RF-Input Load Modulated Balanced Amplifier  
In various implementations of a load modulated balanced amplifier (LMBA), a control signal is generated (e.g., automatically generated) based at least in part on an input signal. The LBMA...
10024854 Method for detecting and purifying pancreatic beta cells  
The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells. Thus, in one aspect, the...
10022543 Cell stimulation using quantum dots  
The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation...
US20180195148 APPARATUS AND METHOD FOR RECOVERY OF MATERIAL  
Systems and methods for recovering material from a gas phase are provided. Exemplary systems include a moving bed of particles onto which material can be deposited. The systems can operate in a...
US20180193193 LACRIMAL DRAINAGE SYSTEM DIAGNOSTIC IMPLANT  
A lacrimal drainage system diagnostic device for analyzing fluid from the eye may include a device body having an internal lumen and configured to be implanted in a lacrimal duct. A power source...
10017760 Methods for generating barcoded combinatorial libraries  
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are...
10017510 Thiol-X click foldamers for polymer affinity and catalysis libraries  
Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected...
US20180187232 EFFICIENT PRODUCTION OF PEPTIDES  
The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than...
US20180185317 IMMUNOTHERAPEUTIC AGENT  
Compounds for use in the treatment of sepsis and/or the prevention or treatment of post-sepsis syndrome.
US20180177180 APPARATUS AND METHODS FOR FREEZING, STORING AND THAWING BIOLOGICAL MATERIALS  
Systems for controlled freezing, storing and thawing a biological material in a bag and supporting apparatus. The systems are adapted to receive the biological material therein for freezing,...
10004635 Nasolacrimal implants and related methods for tear stimulation  
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also...
10004634 Nasolacrimal implants and related methods for tear stimulation  
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also...
9999224 Antimicrobial reverse thermal gel and methods of forming and using same  
Antimicrobial polymers, composition including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties...
US20180166915 WIRELESS POWER TRANSFER  
A capacitive wireless power transfer (WPT) architecture that provides for dynamic (i.e., in motion) and/or stationary power transfer is provided. In various implementations, for example, the...
US20180161283 METHODS AND PRODUCTS FOR TREATING AND/OR DELAYING ONSET OF DYSPLASTIC LESIONS  
Methods for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual comprise delivering to the respiratory track of the individual an inhalable dry powder...
US20180161153 MODULAR INTRAOCULAR LENS DESIGNS, TOOLS AND METHODS  
Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged...
9994901 Pro-inflammatory mediators in diagnosis and treatment of chronic obstructive pulmonary disease  
Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease. Various pro-inflammatory mediators are elevated in a model of COPD that can be...
US20180156782 Methods for Treatment with Bucindolol Based on Genetic Targeting  
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
US20180154151 SYSTEMS AND METHODS FOR PREVENTING, DIAGNOSING, AND/OR TREATING ONE OR MORE MEDICAL CONDITIONS VIA NEUROMODULATION  
Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or...
US20180153373 PEDIATRIC NASAL ENDOSCOPE, GASTROSCOPE AND AERODIGESTIVE SCOPE  
TNE provides the opportunity to make the care of children with EoE and other gastrointestinal or aerodigestive conditions safer, more efficient, and less costly while simultaneously advancing our...
9991176 Non-destructive acoustic metrology for void detection  
Advanced interconnect technologies such as Through Silicon Vias (TSVs) have become an integral part of 3-D integration. Methods and systems and provided for laser-based acoustic techniques in...
9987393 Covalently cross linked hydrogels and methods of making and using same  
A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol...