Patents and Patent Applications from University of Colorado


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US20170297206 MEASURING DISTANCE AND CONTACT FORCE DURING ROBOTIC MANIPULATION  
A force, distance and contact measurement system comprising at least one low-cost tactile sensor embedded in elastomer and retrofitted onto existing robotic grippers is provided. The sensor is...
9788938 Intraocular manipulator and related methods  
In accordance with various embodiments, an intraocular manipulator is disclosed which uses negative pressure to grasp and/or manipulate an intraocular object, for example, an IOL, a crystalline...
US20170292073 COMPOSITIONS COMPRISING ANISOTROPIC NANOPARTICLE LIQUID CRYSTAL DISPERSIONS HAVING TUNABLE OPTICAL PROPERTIES  
Disclosed herein are compositions, comprising one or more types of surface modified anisotropic nanoparticles dispersed in a liquid crystal. The compositions provide tunable methods for modifying...
US20170290930 Light-Emitting Versions of the Monoclonal Antibody to C3D (MAB 3D29) for Imaging  
The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for...
9787051 Compact optical frequency comb systems  
Compact optical frequency sources are described. The comb source may include an intra-cavity optical element having a multi-material integrated structure with an electrically controllable active...
US20170281754 Compositions and Methods for Enhanced Innate Immunity  
The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9...
US20170281020 Rapid Detection of Bleeding Following Injury  
Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patient is bleeding, in some cases, noninvasively. In various embodiments, tools and...
9778152 Cell collecting apparatus and method of use  
The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device 100 that is operated by...
9775876 Compositions and methods for CaMKII inhibitors and uses thereof  
Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further...
US20170279147 MODULAR BIOELECTROCHEMICAL SYSTEMS AND METHODS  
Bioelectrochemical systems (BES) having configurations with spiral wound structures and with frame-and-plate structures are provided. Systems may allow for production of an electrical current that...
US20170273927 METHODS OF TREATING AUTOIMMUNITY  
Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides...
US20170269297 Method and Apparatus for Optical Waveguide-to-Semiconductor Coupling for Integrated Photonic Circuits  
A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated...
US20170269088 TARGETING BREAST CANCER THERAPY BASED ON STROMAL SUBTYPES AND CD146 COMPOSITION  
Methods for targeted breast cancer therapy in a subject based upon evaluating the stromal subtypes and CD146 composition in the adjacent tissue. ER+ breast cancers contain two CAF subtypes defined...
US20170265851 OCULAR TISSUE EXPANSION RING  
The present disclosure relates to a structure used in an ophthalmic surgical procedure. The device may be used in pupil expansion or stabilization of the iris. The device is made out of an elastic...
9767940 Superconducting cables and methods of making the same  
Superconducting cables employ one or more superconducting tapes wound around a former. A compact superconducting cable is configured using a former having a small diameter, e.g., less than 10...
US20170260589 POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME  
Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment...
9759731 Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis  
A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function...
9758597 Reducing polymerization-induced shrinkage stress by reversible addition-fragmentation chain transfer  
The invention provides methods of reducing shrinkage stress in cross-linked polymerized materials by combining an addition-fragmentation chain transfer additive with a resin system prior to...
9757279 Intraocular device for dual incisions  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
9757041 Hemodynamic reserve monitor and hemodialysis control  
Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's...
US20170255003 Electrowetting-Actuated Optical Shutters  
Electrowetting-actuated optical shutters based on total internal reflection or beam steering. An electrowetting cell contains a conducting liquid and a non-conducting liquid configured to form a...
US20170254807 Method For Detecting And Purifying Pancreatic Beta Cells  
The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells. Thus, in one aspect, the...
US20170253865 Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof  
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the...
US20170248381 RADIATIVE COOLING STRUCTURES AND SYSTEMS  
Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative...
US20170247767 Biomarkers For Head And Neck Cancer And Methods Of Their Use  
Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell...
US20170247541 DEGRADABLE THIOL-ENE POLYMERS  
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated...
9745266 Indoline alkaloid compounds  
The present invention relates to indoline alkaloid compounds. In particular, indoline alkaloid compounds of the invention have antibacterial activity and/or are capable of resensitizing the...
US20170240922 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
US20170240615 COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTITRYPSIN Fc FUSION MOLECULES  
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive...
US20170240613 COMPOSITIONS AND METHODS FOR MODULATING T-CELL MEDIATED IMMUNE RESPONSE  
The present disclosure relates to compositions and methods for modulating T-cell mediated immune response in a subject in need thereof. The method includes administering to the subject an...
US20170239284 ANTIBODY-SIRNA CONJUGATES AND USES THEREFOR  
The disclosure provides compositions and methods relating to the treatment of pain, such as pain from rheumatoid arthritis. By creating conjugates of antibodies that target C5aR and siRNA's that...
US20170239176 MULTILAYER POLYMERIC MATRIX BASED MEDICAL DEVICES  
The disclosure relates to multilayer polymeric matrix based medical devices. In one example, a device comprises an inner first polymeric matrix and an outer second polymeric matrix. The addition...
9740799 Cut-fold shape technology for engineered molded fiber boards  
A three-dimensional engineered shaped fiber configuration is formed using determined structural requirements for a three-dimensional engineered shaped fiber configuration and ascertained...
US20170237119 LI-ION ELECTROLYTE MEMBRANE FACILITATED BY A SELF-HEALING POLYMER MATRIX, AND ASSOCIATED BATTERY  
Disclosed herein are compositions and methods of making novel covalently cross-linked polyimines that are non-malleable under standard conditions but yet may be rendered malleable. Also disclosed...
US20170232143 COVALENTLY CROSS LINKED HYDROGELS AND METHODS OF MAKING AND USING SAME  
A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol...
9731045 Shape memory polymer  
A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50°...
US20170224787 COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA  
Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases...
US20170224646 COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISEASE  
The present invention provides a method and composition for treating a neurodegenerative disease. In particular, the present invention provides a method and composition to increase DJ-1 gene...
US20170222393 Generation of VUV, EUV, and X-ray Light Using VUV-UV-VIS Lasers  
A method for extending and enhancing bright coherent high-order harmonic generation into the VUV-EUV-X-ray regions of the spectrum involves a way of accomplishing phase matching or effective phase...
US20170221778 NON-DESTRUCTIVE ACOUSTIC METROLOGY FOR VOID DETECTION  
Advanced interconnect technologies such as Through Silicon Vias (TSVs) have become an integral part of 3-D integration. Methods and systems and provided for laser-based acoustic techniques in...
US20170218025 BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF  
The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds,...
US20170216097 INTRAOCULAR DEVICE FOR DUAL INCISIONS  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
US20170209555 Compositions and Methods for Modulating Cardiac Conditions  
Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or...
US20170209549 MAP44 POLYPEPTIDES AND CONSTRUCTS BASED ON NATURAL ANTIBODIES AND USES THEREOF  
The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope...
US20170209273 SYSTEM AND METHOD OF OSTEODISTRACTION  
Systems, devices, and methods for osteodistraction are provided. The systems and devices comprise ellipsoidal cams for providing controlled distraction of adjacent bone structures using a...
US20170204112 ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME  
Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the...
US20170202847 METHODS FOR THE TREATMENT OF TUMORS  
The present invention is directed to methods of treating a tumor, in particular human tumors, including administering an effective amount of a MER tyrosine kinase inhibitor (MER TKI) to inhibit...
US20170202487 DIAGNOSTIC TOOL FOR MEASURING OSSICULAR CHAIN COMPLIANCE  
The disclosure provides systems and methods of use pertaining to precise measurements of middle ear mechanics to aid physicians in the determination of pre-operative, intraoperative, and...
9712066 Assisted zero voltage switching for a DC-to-DC converter  
An apparatus includes a first auxiliary switch connected to a positive connection of a switching leg of a DC-to-DC converter. The switching leg includes a first main switch and a second main...
9701792 Composite compositions and methods of preparing and using same  
The present invention includes compositions comprising an alkyne-based substrate, an azide-based substrate, optionally a Cu(II) salt and optionally a photoinducible reducing agent. The present...