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US20120128724 |
SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter...
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8184279 |
Fourier domain sensing
Methods, systems, and apparatuses are provided for measuring one or more sinusoidal Fourier components of an object. A structured second radiation is generated by spatially modulating a first...
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8181544 |
Liquid sample evaporator for vapor analysis
Preparation methods for introducing liquid samples to gas analysis instruments include 1) complete evaporation of a liquid sample in a sample chamber, and 2) allowing the sample vapor in the sample...
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US20120116504 |
Reliably Retained Shape Memory Ophthalmological Implants
An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device...
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US20120116252 |
SYSTEMS AND METHODS FOR DETECTING BODY ORIENTATION OR POSTURE
Systems and methods for detecting body orientation and/or posture are provided. At least one wave sensor may be configured to output waves and collect measurements data based upon the reflections...
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US20120113513 |
SELF-CLEANING OF OPTICAL SURFACES IN LOW-PRESSURE REACTIVE GAS ENVIRONMENTS IN ADVANCED OPTICAL SYSTEMS
Apparatus and methods for self-cleaning of optical elements in sealed environments over a wide range of operating optical frequencies prevent long-term power degradation by introducing low-pressure...
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US20120108492 |
LIGAND-SPECIFIC NON-ANTIBODY COMPOUNDS THAT INHIBIT CR2 ACTIVATION AND METHODS OF USE THEREOF
The present invention describes a novel non-antibody ligand-specific compound that selectively binds to a complement receptor type 2 (CR2) protein, a ligand thereof, or both, wherein the compound...
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8170644 |
Method for fast multi-slice mapping of myelin water fraction
Mapping of myelin water content in white matter may provide important information for early diagnosis of multiple sclerosis and the detection of white matter abnormality in other diseases. It is...
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8168415 |
Axl fusion proteins as Axl tyrosine kinase inhibitors
Disclosed are novel inhibitors of the Axl receptor tyrosine kinase (RTK) and methods of using such inhibitors in a variety of therapeutic approaches in the areas of cancer therapy and...
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US20120101162 |
METHODS AND COMPOSITIONS FOR INDUCING PHYSIOLOGICAL HYPERTROPHY
Methods and compositions are provided for inducing physiologic hypertrophy in a cell for treatment or prevention of a cardiovascular disease or condition. In certain embodiments methods and...
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US20120100301 |
Nucleation of Ultrathin, Continuous, Conformal Metal Films Using Atomic Layer Deposition And Application As Fuel Cell Catalysts
A method to achieve a conformal ultrathin film of platinum or one of its alloys on a substrate that can be economically used as a heterogeneous catalyst, such as automotive polymer electrolyte...
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8163509 |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the...
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US20120092632 |
DIFFRACTION UNLIMITED PHOTOLITHOGRAPHY
Methods, devices, systems, and materials are disclosed for diffraction unlimited photofabrication. A method is provided where a photoresponsive material is illuminated with a first optical pattern...
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US20120087936 |
THERAPEUTIC AND PROPHYLACTIC VACCINE FOR THE TREATMENT AND PREVENTION OF PAPILLOMAVIRUS INFECTION
Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions...
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8153136 |
Yeast-based vaccines as immunotherapy
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
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US20120071432 |
CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS
The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-ac-Live agents. In particular embodiments, intrathecal administration is advantageous...
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US20120070442 |
METHODS AND COMPOSITIONS FOR TREATING CANCER
Provided herein are methods for identifying a cancer patient responsive to treatment with an EGFR tyrosine kinase inhibitor. One method comprises obtaining a biopsy from the patient and measuring...
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US20120070406 |
THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY
The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical...
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8138312 |
Compositions for regulation of tumor necrosis factor-alpha
The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In...
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8137672 |
Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or...
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US20120065709 |
METHODS AND DEVICES FOR VISIBLE LIGHT MODULATION OF MITOCHONDRIAL FUNCTION IN HYPOXIA AND DISEASE
The present invention provides methods of using electromagnetic radiation in the visible portion of the spectrum to modulate mitochondrial function in the treatment of various conditions, including...
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US20120064009 |
METHODS OF LEUKEMIA CELL DETECTION
Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time,...
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8133531 |
Titanium dioxide particles coated via an atomic layer deposition process
Titanium dioxide particles are coated first with an interstitial coating and then with silicon dioxide or alumina. The coatings are suitably applied via an atomic layer deposition process. The...
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US20120058091 |
DIAGNOSTIC AND THERAPEUTIC TREATMENTS RELATED TO MITOCHONDRIAL DISORDERS
The invention is based in part on the discovery that chromosomal disorders such as Down Syndrome can be diagnosed by assessing maternal mitochondrial status. Thus the invention relates to...
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8130522 |
Digital power factor correction
A digital PFC (DPFC) control approach that requires no input voltage sensing or current loop compensation is described. The approach can provide stable, low-harmonic operation over a universal...
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8123678 |
Endoscope apparatus, actuators, and methods therefor
The present invention provides, in part, a dexterous endoscope apparatus, referred to herein as a MicroFlex Scope (MFS). The MFS is an novel, small diameter, e.g., less about 1 mm to about 4 mm,...
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US20120046687 |
Vascular Occlusion Devices
Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical...
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US20120046225 |
STABLE GLUCAGON FORMULATIONS FOR THE TREATMENT OF HYPOGLYCEMIA
The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via,...
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US20120042588 |
INTEGRATED PHOTOVOLTAIC MODULE
The disclosed embodiments increase the power generated by a photovoltaic (PV) array, when the PV panels within the PV array are not uniformly illuminated or oriented or when PV panels are...
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8119128 |
Antibodies that bind urokinase-type plasminogen activator and epitopes therefor
Anti-uPA antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of...
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US20120040896 |
COMPOSITIONS, METHODS AND USES FOR MODULATION OF BRCA 1
Embodiments of the present invention generally relate to methods, compositions and uses for diagnosis and treatment of cancer. Certain embodiments report methods and compositions for diagnosing...
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8112594 |
Efficient point-to-point enqueue and dequeue communications
Systems and methods for writing and/or reading data to a point-to-point shared memory communication mechanism are provided according to embodiments disclosed herein. According to one embodiment, a...
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US20120022011 |
HSP90 INHIBITORS WITH MODIFIED TOXICITY
The invention provides purified 19-substituted geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the...
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US20120016102 |
NON-TOXIC BIOFILM INHIBITOR
The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the...
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US20120016052 |
Stress Relaxation in Crosslinked Polymers
The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving...
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US20120015872 |
COMPLEMENT RECEPTOR 2 TARGETED COMPLEMENT MODULATORS
Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that...
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US20120014972 |
INFLUENZA VIRUS COMPOSITIONS AND METHODS FOR UNIVERSAL VACCINES
The disclosure relates at least in part to embodiments of compositions and methods including vaccines for protection against multiple serologically distinct strains of influenza virus. This...
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US20120014952 |
COMPLEMENT RECEPTOR 2 TARGETED COMPLEMENT MODULATORS
Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that...
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US20120009212 |
CONJUGATES UTILIZING PLATFORM TECHNOLOGY FOR STIMULATING IMMUNE RESPONSE
Templated conjugates created from naturally-occurring protein sequences found in pathogens, such as viruses, are disclosed. The sequences are “templated” into a consensus coiled-coil sequence in ...
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US20120006194 |
HIGH FLUX SAPO-34 MEMBRANES FOR CO2/CH4 SEPARATION AND TEMPLATE REMOVAL METHOD
The present invention provides methods for making improved zeolite and crystalline silicoaluminophosphate (SAPO) membranes, in particular SAPO-34 membranes, on a porous support through improved...
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8093286 |
Methods for treatment with bucindolol based on genetic targeting
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
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US20110318335 |
METHODS AND PRODUCTS FOR TREATING PROLIFERATIVE DISEASES
Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of...
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8080778 |
Channel cell system
The present invention provides an improved cold-atom system having multiple chambers such that a first of the chambers includes an atom source. The system also includes an atom trap disposed inside...
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8080578 |
Methods for treatment with bucindolol based on genetic targeting
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
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8076304 |
Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions
The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by...
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8071645 |
Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter...
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8067327 |
Membranes for highly selective separations
The present invention provides modified molecular sieve membranes with improved CO2/CH4 separation selectivity and methods for making such membranes. The molecular sieve membranes are modified by...
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US20110286938 |
NON-INVASIVE DETECTION OF COMPLEMENT-MEDIATED INFLAMMATION USING CR2-TARGETED NANOPARTICLES
Methods of non-invasive imaging of complement-mediated inflammation are provided. Compositions including CR-targeted ultrasmall superparamagnetic nanoparticles or aggregates thereof for use with...
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8062643 |
Use of neurotoxin therapy for treatment of urologic and related disorders
The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.
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US20110282169 |
Long Term Active Learning from Large Continually Changing Data Sets
Methods and systems are disclosed for autonomously building a predictive model of outcomes. A most-predictive set of signals Sk is identified out of a set of signals s1, s2, . . . , sD for each of...
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