Patents and Patent Applications from University of Colorado


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9999224 Antimicrobial reverse thermal gel and methods of forming and using same  
Antimicrobial polymers, composition including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties...
US20180166915 WIRELESS POWER TRANSFER  
A capacitive wireless power transfer (WPT) architecture that provides for dynamic (i.e., in motion) and/or stationary power transfer is provided. In various implementations, for example, the...
US20180161283 METHODS AND PRODUCTS FOR TREATING AND/OR DELAYING ONSET OF DYSPLASTIC LESIONS  
Methods for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual comprise delivering to the respiratory track of the individual an inhalable dry powder...
US20180161153 MODULAR INTRAOCULAR LENS DESIGNS, TOOLS AND METHODS  
Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged...
9994901 Pro-inflammatory mediators in diagnosis and treatment of chronic obstructive pulmonary disease  
Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease. Various pro-inflammatory mediators are elevated in a model of COPD that can be...
US20180156782 Methods for Treatment with Bucindolol Based on Genetic Targeting  
The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer...
US20180154151 SYSTEMS AND METHODS FOR PREVENTING, DIAGNOSING, AND/OR TREATING ONE OR MORE MEDICAL CONDITIONS VIA NEUROMODULATION  
Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or...
US20180153373 PEDIATRIC NASAL ENDOSCOPE, GASTROSCOPE AND AERODIGESTIVE SCOPE  
TNE provides the opportunity to make the care of children with EoE and other gastrointestinal or aerodigestive conditions safer, more efficient, and less costly while simultaneously advancing our...
9991176 Non-destructive acoustic metrology for void detection  
Advanced interconnect technologies such as Through Silicon Vias (TSVs) have become an integral part of 3-D integration. Methods and systems and provided for laser-based acoustic techniques in...
9987393 Covalently cross linked hydrogels and methods of making and using same  
A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol...
US20180149567 Torsion Testing Devices and Methods  
A torsional testing device for testing helical tensile strength, shear strength, and interface bond shear strength using an apparatus to apply torsional loads on a cylindrical specimen is...
US20180148442 Polycyclic Indoline and Indolenine Compounds  
The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are...
US20180146848 PEDIATRIC NASAL ENDOSCOPE, GASTROSCOPE AND AERODIGESTIVE SCOPE  
TNE provides the opportunity to make the care of children with EoE and other gastrointestinal or aerodigestive conditions safer, more efficient, and less costly while simultaneously advancing our...
US20180146839 MULTI-USE SCOPE  
An endoscope/triplescope (combined gastroscope, bronchoscope, laryngoscope) device and/or system includes an endoscope having an outer diameter of less than about 4.0 millimeters, in particular...
9982278 CRISPR enabled multiplexed genome engineering  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
9980853 Non-invasive device for lowering intraocular pressure  
The present invention provides devices and methods for non-invasively lowering intraocular pressure. In particular, some non-invasive intraocular pressure lowering devices of the invention...
9980634 Minimally-invasive measurement of esophageal inflammation  
The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to...
US20180142264 NANOPARTICLE BIOHYBRID COMPLEXES  
Disclosed herein are biohybrid protein complexes capable of using light energy to photocatalyze the reduction of N2 into NH3. Also provided are methods of using biohybrid protein complexes to...
US20180142145 DOPED SEMICONDUCTORS AND METHODS OF MAKING THE SAME  
The present disclosure relates to a composition that includes a first element, a second element, a third element, a ligand, and an anion, where the first element and the second element form a...
US20180140841 SYSTEMS AND METHODS FOR PREVENTING, DIAGNOSING, AND/OR TREATING ONE OR MORE MEDICAL CONDITIONS VIA NEUROMODULATION  
Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or...
US20180140688 PROPIONYL-COA CARBOXYLASE COMPOSITIONS AND USES THEREOF  
This invention provides compositions of human propionyl-CoA carboxylase (PCC) and pharmaceutical compositons of human PCC and methods for treating conditions such as propionic acidemia (PA),...
US20180140493 SURGICAL TABLE AND ACCESSORIES TO FACILITATE HIP ARTHROSCOPY  
Embodiments disclosed herein concern a distraction system for use with a surgical table having a table portion and a base portion. The distraction system includes a pair of arms rotatably...
US20180133478 SYSTEMS AND METHODS FOR PREVENTING, DIAGNOSING, AND/OR TREATING ONE OR MORE MEDICAL CONDITIONS VIA NEUROMODULATION  
Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or...
US20180133294 COMPOSITIONS AND METHODS RELATED TO GRAFT VERSUS HOST DISEASE AND TREATMENTS THEREOF  
Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In particular, the present invention relates to...
US20180133056 INTRAOCULAR DEVICE FOR DUAL INCISIONS  
A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade...
US20180128553 METHOD AND DEVICE FOR SPREADING HIGH HEAT FLUXES IN THERMAL GROUND PLANES  
A thermal ground plane with hybrid structures that include nanowires is disclosed. The thermal ground plane includes a first casing having an exterior surface and an interior surface, the interior...
9967541 3D imaging, ranging, and/or tracking using active illumination and point spread function engineering  
Imaging systems and imaging methods are disclosed to estimate a three-dimensional position of an object at a scene and/or generate a three-dimensional image of the scene. The imaging system may...
9962112 Medical systems and methods of use  
This invention provides ambulatory medical systems that include a monitoring device, a therapeutic substance administering device, and a receiver-controller for receiving a signal generated by the...
US20180118801 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AUTOIMMUNE DISEASES  
Disclosed are compositions and methods for detecting, isolating, and/or characterizing a T cell or autoantibody associated with type I diabetes. The composition and methods comprise the use of a...
US20180117577 NANOSTRUCTURED PHOTOCATALYSTS AND DOPED WIDE-BANDGAP SEMICONDUCTORS  
Photocatalysts for reduction of carbon dioxide and water are provided that can be tuned to produce certain reaction products, including hydrogen, alcohol, aldehyde, and/or hydrocarbon products....
US20180117186 MAGNETIC PARTICLES FOR USE IN MAGNETIC RESONANCE IMAGING THERMOMETRY  
The present invention provides doped ferrite particles or metallic compounds or alloys, which can be used as temperature-dependent sensors in magnetic resonance imaging. In certain embodiments,...
US20180117124 INSULIN MIMOTOPES AND METHODS OF USING THE SAME  
Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T...
US20180116988 METHODS OF PREVENTING AND TREATING AUTOIMMUNITY  
Methods of preventing, treating or ameliorating autoimmune diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune...
US20180116872 NASOLACRIMAL IMPLANTS AND RELATED METHODS FOR TEAR STIMULATION  
A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also...
US20180110756 ANTHRACYCLINE PRODRUGS AND METHODS OF MAKING AND USING THE SAME  
Therapeutically effective prodrug compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of making and using these...
9950044 Treatment of pulmonary vascular remodeling with neprilysin  
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming...
9949928 Biodegradable copolymers, systems including the copolymers, and methods of forming and using same  
Therapeutic agent delivery systems, which include a thermally-sensitive copolymer and optionally a therapeutic agent, are disclosed. The copolymer is water soluble and biodegradable and, in...
9949484 Antimicrobial polyurethane materials and methods of forming and using same  
Antimicrobial quaternized polyurethane materials and methods of forming and using the materials are disclosed. The quaternized polyurethane antimicrobial materials may be synthesized from one or...
US20180105726 Water Compatible Nanogel Compositions  
The present invention relates to preparation and use of water dispersible nanogels and solvent dispersible reactive nanogels as additives to enhance polymer properties or as precursors to...
US20180105668 METHODS OF ISOLATING MELT-PROCESSIBLE POLYCARBONATE FROM PLASTIC WASTE, METHODS OF PREPARING POLYCARBONATE-CONTAINING HYBRID POLYMERS, AND COMPOSITIONS COMPRISING SAME  
This invention provides methods to separate polycarbonates from plastic swarf. The present invention further provides methods of generating novel materials from post-processing polymers.
9948423 Variation-tolerant wavelength division multiplexing receiver and transceiver, and associated methods  
A variation-tolerant receiver includes a plurality of receiver resonators configured to demultiplex a multiplexed modulated signal received from at least one wavelength division multiplexing (WDM)...
US20180100036 CLICK NUCLEIC ACID POLYMERS AND METHODS OF USE  
Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for...
9939448 Methods for detecting insulin autoantibody  
The present invention provides methods for detecting insulin autoantibody. Such methods can be used, for example, to predict susceptibility of and/or diagnose the presence of Type 1 diabetes in a...
9938353 Compositions, methods and uses for alpha-1 antitrypsin fusion molecules  
Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct...
US20180092851 Thermostable Vaccine Compositions and Methods of Preparing Same  
Compositions relating to thermostable vaccines and methods of preparing same. Specifically, methods of preparing thermostable vaccines based on a recombinant ricin neurotoxin protein and uses of...
US20180088204 MOBILE DEVICES FOR TRACKING A RADIATION DISK LIGHT SOURCE AND METHODS USING SAME  
The invention provides in one aspect a fast digital light source tracker aboard a moving ground-based or airborne platform. The tracker consists of two rotating mirrors, a lens, an imaging camera,...
US20180087102 QUANTUM MOLECULAR SEQUENCING (QM-SEQ): IDENTIFICATION OF UNIQUE NANOELECTRONIC TUNNELING SPECTROSCOPY FINGERPRINTS FOR DNA, RNA, AND SINGLE NUCLEOTIDE MODIFICATIONS  
Techniques, methods, devices, and compositions are disclosed that are useful in identifying and sequencing natural and synthetic, and modified and unmodified DNA, RNA, PNA, DNA/RNA nucleotides....
9925162 Methods and compositions for inducing physiological hypertrophy  
Methods and compositions are provided for inducing physiologic hypertrophy in a cell for treatment or prevention of a cardiovascular disease or condition. In certain embodiments methods and...
9925040 Modular intraocular lens designs, tools and methods  
Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged...
9924723 Delivery of heavy metals for the inhibition of microbially induced concrete corrosion  
The present invention provides concrete-containing compositions, and methods of making and using the same, that allow for the prevention of microbially induced corrosion in concrete. In certain...