Patents and Patent Applications from University of Cincinnati


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US20160237989 VERTICAL AXIS WIND TURBINES AND RELATED METHODS OF BRAKING  
An exemplary vertical axis wind turbine includes a support structure rotatable about a vertical turbine axis, and at least two blades each operatively coupled to the support structure and...
US20160236938 METHODS TO SUPERHEAT CARBON NANOTUBES  
A method for annealing multi-walled carbon nanotubes includes applying a high-frequency electromagnetic field to the carbon nanotubes and causing the carbon nanotubes to self-heat to a temperature...
9409975 Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
US20160220146 Water and Salt Resistant Solid Super-Acid Catalysts  
Methods for preserving catalytic activity of a PSA polymer membrane in a humid environment by immobilizing in the membrane an organic acid having a pKa greater than the pKa of the PSA polymer...
9394343 Appetite stimulating protein  
An engineered polypeptide comprising an AgRP analog with increased basic residues compared to the wild type polypeptide, wherein the polypeptide, when introduced into the CNS of a mammal,...
9394233 ROS-activated compounds as selective anti-cancer therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer...
US20160201035 Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...
9387066 Elements for versatility of a prosthetic anchor  
A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each...
US20160193190 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or...
US20160163305 Variable Bandwidth Delayless Subband Algorithm For Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors programmed to implement a delayless subband filtered-x least mean square control algorithm. The algorithm...
US20160163304 Subband Algorithm With Threshold For Robust Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors. The one or more processors implement an adaptive subband filtered reference control algorithm that applies...
US20160160220 Methods and Compositions for Treating Autoimmune Disorders by Targeting Kv1.3 Ion Channels with Functionalized Lipid-Derived Nanovesicles  
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased...
9357970 Apparatuses and methods for neurological status evaluation using electromagnetic signals  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
US20160144203 Ultrasound-Mediated Inducement, Detection, and Enhancement of Stable Cavitation  
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes...
9320472 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Apparatuses and methods for neurological status evaluation using electromagnetic signals
 
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
9314014 Compositions and methods for the storage of red blood cells  
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a...
US20160101188 NOVEL NANOCARRIER DELIVERED CANCER CHEMOTHERAPEUTIC AGENTS  
Compositions and methods for treating cancer in a subject are described herein. The composition includes modified nucleobases and nucleosides that are converted in the cell to nucleotides that are...
9297013 pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles  
Trifurcate RNA junction domains derived from phi29 pRNA are described that assemble with high affinity and that are stable in vitro and in vivo. Further expansion of trifurcated RNA domains to...
US20160083353 SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS  
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also...
9266941 Apolipoprotein AIV as an antidiabetic peptide  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20160041105 Optical Sensor  
An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition...
US20160024551 MULTI-TIERED, HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM  
A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each...
US20160008305 TREATMENT OF A DIASTOLIC CARDIAC DYSFUNCTION WITH A TRPV2 RECEPTOR AGONIST  
Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor...
9233099 Methods of treating cognitive dysfunction by modulating brain energy metabolism  
Methods for treating cognitive dysfunction by modulating brain energy metabolizm using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed.
9216171 Methods of preventing ischemic injury using peripheral nociceptive stimulation  
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and...
9211490 Electrofluidic textiles and cleaning implements using such electrofluidic textiles  
The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting,...
US20150344955 METHODS FOR DETECTION AND QUANTIFICATION OF EGFRvIII IN THE PERIPHERAL BLOOD OF GBM PATIENTS  
Methods and kits for detection and quantification of EGFRvIII in the peripheral blood for monitoring the therapy of a GBM patients.
9200037 Compounds for control of appetite  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs...
9180454 Electrowetting and electrofluidic devices with laplace barriers and related methods  
Electrowetting and electrofluidic devices and methods. The device includes a hydrophobic channel formed between first and second substrates and a polar fluid and a non-polar fluid contained in the...
US20150309099 SENSOR SLEEVE FOR HEALTH MONITORING OF AN ARTICLE  
A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode...
US20150309022 Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens  
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1...
US20150306189 Compositions and Methods for Inducing Liver Regeneration by Administering Hepatocyte-Derived Exosomes  
A pharmaceutical composition containing (1) a therapeutically effective amount of hepatocyte-derived exosomes; and (2) a pharmaceutically-acceptable carrier is provided. Also provided herein is a...
US20150299251 Skin Care Compositions and Methods Comprising Selective Agonists of Melanocortin 1 Receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin...
US20150297667 PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS OF USE COMPRISING SELECTIVE AGONISTS OF MELANOCORTIN 1 RECEPTOR  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are...
US20150293347 ELECTROFLUIDIC DISPLAY AND METHODS FOR MAKING  
A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters...
US20150293346 DOSING AND SEALING OF FLUID-BASED ELECTRO-OPTICAL DEVICES AND DISPLAYS  
A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate;...
US20150292023 Materials and Methods Related to NSAID Chemoprevention in Colorectal Cancer  
Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In...
US20150290300 Materials and Methods Useful for Treating Glioblastoma  
The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when...
US20150283005 DEVICES AND METHODS FOR DIRECTING A MEDICAL FABRIC INTO A PORTION OF THE BODY  
A device (10) for directing a medical fabric (28) into a portion of a body. An elongated housing (12) having a distal end (16) and an opening (22) at the distal end (16). A supply of medical...
US20150274621 Homogeneous Hydrogenation of Esters Employing a Complex of Iron as Catalyst  
The homogeneous hydrogenation of organic carbonyls, especially esters, under relatively mild conditions using iron hydrido-borohydride catalyst complexes having amino-phosphine pincer ligands. The...
US20150252095 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20150246125 Methods and Compositions for Suppressing IgE-Mediated Anaphylaxis  
Methods for suppressing IgE-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the...
9122005 Electrowetting retroreflector devices, systems, and methods  
Switchable retroreflector devices that are modulated via electrowetting. The devices include an electrically-conductive polar fluid and a non-polar fluid that is immiscible with the polar fluid....
9114148 Modulating phosphatase activity in cardiac cells  
Expression of a phosphatase inhibitor in heart cells can be used to treat cardiac disorders, e.g., heart failure. Decreasing phosphatase activity can improve β-adrenergic responsiveness.
9113559 Pressure reconfigured electromagnetic devices  
A reconfigurable electromagnetic device includes a first and second planar layer having facing surfaces. One of the surfaces includes one or more micro-trenches. The area between the two surfaces...
US20150225658 METHOD OF EXTRACTING LIPIDS FROM TRAP GREASE WITH WASTE COOKING OIL  
Describe are methods of extracting the lipid fraction from trap grease using vegetable oil, such as vegetable oils sourced from waste cooking oil. The method includes mixing a volume of vegetable...
9081171 Spectrum-modulated smart windows  
Methods, systems, devices and/or apparatuses are provided that selectively reflect the infrared spectrum independent of other regions of the solar spectrum in order to actively manage solar heat...
US20150182591 METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV  
Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include...
US20150164986 METHOD OF TREATING TYPE I DIABETES USING APOLIPOPROTEIN AIV  
Methods for treating type one diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type one diabetes mellitus are disclosed, including combination...
9051394 Apolipoprotein AIV as an antidiabetic peptide  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...