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Patents and Patent Applications from University of Cincinnati


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US20140370027 INHIBITION OF MACROPHAGE-SYNTHESIZED WNT7B TO INHIBIT TUMOR ANGIOGENESIS AND METASTASIS  
The present invention provides methods of inhibiting angiogenesis in a malignant tumor, inhibiting metastasis of a malignant tumor and of inhibiting transformation of a benign tumor to a malignant...
8912359 Bisbenzamidines for the treatment of pneumonia  
A method of combating infectious agents, such as Pneumocystis pneumonia, and a method of treating a subject in need of such treatment is disclosed. The method comprises administering to the subject...
US20140350676 ELEMENTS FOR VERSATILITY OF A PROSTHETIC ANCHOR  
A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each...
US20140315012 NANO-GRAPHENE SHEET-FILLED POLYIMIDE COMPOSITES AND METHODS OF MAKING SAME  
A composite material including a dispersion of nano-graphene sheet particles in a polyimide matrix and a method making films of the composite material are provided. The method includes forming a...
US20140308326 ANTIMICROBIAL COMPOSITIONS OF AMINOGLYCOSIDIC ANTIBIOTICS AND ZINC ION CHELATORS SPECIFICALLY FORMULATED FOR ENHANCED INHIBITION OF BACTERIAL COLONIZATION AND ANTIBACTERIAL EFFICACY  
Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm...
8852128 Computer system and method for assessing dynamic bone quality  
A computer system for assessing dynamic bone quality is provided, including a memory that stores executable instructions, a central processing unit (CPU) capable of accessing the memory and...
US20140287020 SURGICAL DEVICE FOR SKIN THERAPY OR TESTING  
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin,...
US20140276867 PATIENT-SPECIFIC ASSEMBLIES, JIGS, AND METHODS FOR A PERSONALIZED TOTAL HIP ARTHROPLASTY SYSTEM  
A patient-specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant...
US20140274887 Compounds for Control of Appetite  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs the...
US20140272942 Methods of Detecting Influenza Virus  
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method...
US20140248289 Methods and Compositions for the Treatment of Respiratory Conditions Via NKG2D Inhibition  
Methods and compositions for the treatment of respiratory conditions are provided. Aspects of the subject methods include administering to the subject a composition comprising an inhibitor of...
US20140243647 APPARATUSES AND METHODS FOR NEUROLOGICAL STATUS EVALUATION USING ELECTROMAGNETIC SIGNALS  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna coupled...
US20140235687 METHODS OF TREATING COGNITIVE DYSFUNCTION BY MODULATING BRAIN ENERGY METABOLISM  
Methods for treating cognitive dysfunction by modulating brain energy metabolism using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed.
8810882 Display pixels, displays, and methods of operating display pixels  
Electrofluidic and electrowetting display pixels, electrofluidic and electrowetting displays, and methods of operating electrofluidic and electrowetting display pixels. The pixel includes a...
US20140220009 Compositions and Methods for Treating Cocaine-Related Disorders  
A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human...
US20140208852 MEASURING WALL THICKNESS LOSS FOR A STRUCTURE  
Systems, methods and computer storage mediums accurately measure wall thickness in a region of interest included in complex curved structures. Embodiments of the present disclosure relate to...
8771243 Wound treatment system  
A wound treatment system includes a sponge including a first surface adapted to confront a wound bed of a patient, a drape in contact with a second surface of the sponge, and a vacuum source for...
8765468 Surgical device for skin therapy or testing  
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin,...
US20140179758 PRNA MUTLIVALENT JUNCTION DOMAIN FOR USE IN STABLE MULTIVALENT RNA NANOPARTICLES  
Trifurcate RNA junction domains derived from phi29 pRNA are described that assemble with high affinity and that are stable in vitro and in vivo. Further expansion of trifurcated RNA domains to...
8753602 Composite catalyst and method for manufacturing carbon nanostructured materials  
A method of forming a carbon nanotube array on a substrate is disclosed. One embodiment of the method comprises depositing a composite catalyst layer on the substrate, oxidizing the composite...
8753392 Elements for versatility of a prosthetic anchor  
A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each...
US20140154277 Pharmaceutical Compositions Comprising Soluble CD137  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20140154244 Methods of Treating Primary Brain Tumors by Administering Letrozole  
The present disclosure relates to the field of cancer treatment, and more specifically to the field of treatment of primary malignant brain tumors. Provided herein are methods of treating primary...
US20140148402 Diagnostic Assays and Methods of Treating Pneumonia, Sepsis and Systemic Inflammatory Response Syndrome  
Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The...
8729227 Compounds for control of appetite  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs the...
8693081 Electrofluidic imaging film, devices, and displays, and methods of making and using the same  
A device and method of making and using the same. The device includes first and second substrates that are spaced to define a fluid space. Polar and non-polar fluids occupy the fluid space. A first...
8685368 Polyamides for nucleic acid delivery  
A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without...
8673844 Method of inhibiting progression of type 1 diabetes by administering soluble CD137  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20140054067 PRESSURE RECONFIGURED ELECTROMAGNETIC DEVICES  
A reconfigurable electromagnetic device includes a first and second planar layer having facing surfaces. One of the surfaces includes one or more micro-trenches. The area between the two surfaces...
US20140030150 FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS  
A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic...
US20140018385 Identification Of PCNA Targeting Compounds For Cancer Therapy And PCNA Function Regulation  
Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include...
US20140005107 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20130344763 Methods for Electrospinning Hydrophobic Coaxial Fibers into Superhydrophobic and Oleophobic Coaxial Fiber Mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
8600069 Multi-channel active noise control system with channel equalization  
A multiple error filtered-x least mean square (MEFxLMS) algorithm using a channel equalization virtual secondary path for an active noise control/cancellation (ANC) system for treating noise in a...
8563328 Fiber-optic biosensor and biosensing methods  
A method for biosensing that includes passing, via convective flow, a sample believed to contain one or more target biomarkers through a microfluidic channel and over the surface of an optical...
US20130273143 METHODS OF IMPROVING CARDIAC FUNCTION AND ATTENUATING AND/OR PREVENTING CARDIAC REMODELING WITH HSP20  
Methods of improving cardiac function and/or methods for attenuating and/or prevention cardiac remodeling in an individual's heart comprising administering to an individual an effective amount of...
8557300 Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite  
Methods for treating bacterial respiratory tract infections in an individual comprise administering a therapeutic amount of nitrite composition having a pH of less than 7, and in specific...
US20130239467 METHOD OF EXTRACTING LIPIDS FROM TRAP GREASE WITH WASTE COOKING OIL  
Describe are methods of extracting the lipid fraction from trap grease using vegetable oil, such as vegetable oils sourced from waste cooking oil. The method includes mixing a volume of vegetable...
US20130233081 EMBEDDED OR CLIP-ON DEVICE FOR HEALTH MONITORING OF AN ARTICLE  
A sensor (10, 80) for monitoring health of an associated article (A) (e.g., a fluid connector) including a sensing element (12, 84, 86) disposed along a length of an outer surface of the associated...
8530160 G-protein coupled receptor kinase-5 polymorphism  
The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of...
US20130230542 ROS-Activated Compounds as Selective Anti-Cancer Therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer...
8527223 Methods and systems for energy prognosis  
In one embodiment, a method for managing an industrial process wherein a processor transforms electronic data into an energy prognosis is provided. An energy related test signal including effective...
8524683 Method for decreasing cardiac using a nucleic acid molecule encoding a variant phosphatase inhibitor-1  
The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (I-1). In particular, the I-1 mutant forms comprise altered phosphorylation sites of...
8518320 Methods for electrospinning hydrophobic coaxial fibers into superhydrophobic and oleophobic coaxial fiber mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
US20130215492 ELECTROWETTING DEVICES ON FLAT AND FLEXIBLE PAPER SUBSTRATES  
Electro wetting devices and methods. The electro wetting device 10 includes a grounded electrode 14 on one side of a paper substrate 12. A dielectric layer 16 and a hydrophobic film 20 are...
US20130214677 Nearly Index-Matched Luminescent Glass-Phosphor Composites For Photonic Applications  
A light emitting device is described. The light emitting device includes a base; a light emitting diode supported by the base; a first layer spaced apart from the light emitting diode and including...
US20130203769 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC, or upstream or...
8501478 Trehalose click polymers for delivery of biologically active molecules  
Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click...
US20130189276 METHOD INHIBITING CELL PROLIFERATION INDUCED BY ALTERNATIVELY SPLICED TISSUE FACTOR  
Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration...
US20130186399 ACOUSTIC PRESSURE INDUCERS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA  
Acoustic pressure inducers and methods for treating obstructive sleep apnea are disclosed. In one embodiment, an acoustic pressure inducer includes an actuator housing having an orifice, a tube...