Patents and Patent Applications from University of Cincinnati


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US20170074893 DEVICES AND METHODS FOR ANALYZING A BLOOD COAGULATION PROPERTY  
A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The...
US20170071210 SILVER NANOPARTICLE-ENHANCED PHOTOSENSITIZERS  
The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle...
9585870 Compositions and methods for improving lactation  
The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased PTHrP levels, resulting in the...
9581629 Sensor sleeve for health monitoring of an article  
A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode...
US20170044680 ADDITIVE MANUFACTURING BY LOCALIZED ELECTROCHEMICAL DEPOSITION  
A method of electrolytic additive manufacturing provides 3-D parts. The method can be used to form parts from particulate material in an electrolytic bath. Metal is electrolytically deposited,...
US20170035425 METHODS FOR PARTIAL DIVERSION OF THE INTESTINAL TRACT  
Devices and methods are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the...
US20170029523 STIMULATION VIA TLR4/MD-2 TO REVERSE TYPE 1 DIABETES  
Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed...
9555109 Method of inhibiting cell proliferation induced by alternatively spliced tissue factor by administering a monoclonal antibody  
Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration...
US20170016899 Methods of Detecting Influenza Virus  
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method...
US20160376654 Temporal Pediatric Sepsis Biomarker Risk Model  
Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses...
US20160376447 CORROSION RESISTANT HYBRID SILANIZED EPOXY ESTER RESINS, COATINGS AND SURFACE PRE-TREATMENT FORMULATIONS  
A self-healing coating composition for use on metals includes a polyurea, an epoxy ester unsaturated resin, a combination of amine terminated siloxane and epoxy terminated siloxane and an...
9526514 Patient-specific assemblies, jigs, and methods for a personalized total hip arthroplasty system  
A patient-specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant...
9506855 Method and system for analyzing a colorimetric assay  
Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in...
9487816 Methods of detecting influenza virus  
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method...
US20160318849 Hydrogen Peroxide-Activated Compounds as Selective Anti-Cancer Therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of hydrogen peroxide and are therefore selective anti-cancer therapeutics for...
9476149 Methods for electrospinning hydrophobic coaxial fibers into superhydrophobic and oleophobic coaxial fiber mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
US20160278653 APPARATUSES AND METHODS FOR NEUROLOGIC STATUS EVALUATION USING ELECTROMAGNEITC SIGNALS  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
US20160266100 Enhanced Capture of Magnetic Microbeads in Microfluidic Devices Using Sequentially Switched Electroosmotic Flow  
Methods of increasing the capture efficiency of a microfluidic device for a target reagent, without additional complications to the design of existing microfluidic devices, and more particularly...
US20160263151 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL INFECTION  
Compositions and methods of utilizing the same are provided for treating bacterial infections. The compositions comprise acidified nitrite in combination with an iron chelator and an antibiotic....
US20160257734 ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
9434764 Skin care compositions and methods comprising selective agonists of melanocortin 1 receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin...
US20160250252 BIOACTIVE GAS-ENCAPSULATED ECHOGENIC LIPOSOMES AND METHODS FOR TREATING CARDIOVASCULAR DISEASE  
Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio...
US20160237989 VERTICAL AXIS WIND TURBINES AND RELATED METHODS OF BRAKING  
An exemplary vertical axis wind turbine includes a support structure rotatable about a vertical turbine axis, and at least two blades each operatively coupled to the support structure and...
US20160236938 METHODS TO SUPERHEAT CARBON NANOTUBES  
A method for annealing multi-walled carbon nanotubes includes applying a high-frequency electromagnetic field to the carbon nanotubes and causing the carbon nanotubes to self-heat to a temperature...
9409975 Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
US20160220146 Water and Salt Resistant Solid Super-Acid Catalysts  
Methods for preserving catalytic activity of a PSA polymer membrane in a humid environment by immobilizing in the membrane an organic acid having a pKa greater than the pKa of the PSA polymer...
9394343 Appetite stimulating protein  
An engineered polypeptide comprising an AgRP analog with increased basic residues compared to the wild type polypeptide, wherein the polypeptide, when introduced into the CNS of a mammal,...
9394233 ROS-activated compounds as selective anti-cancer therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer...
US20160201035 Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...
9387066 Elements for versatility of a prosthetic anchor  
A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each...
US20160193190 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or...
US20160163305 Variable Bandwidth Delayless Subband Algorithm For Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors programmed to implement a delayless subband filtered-x least mean square control algorithm. The algorithm...
US20160163304 Subband Algorithm With Threshold For Robust Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors. The one or more processors implement an adaptive subband filtered reference control algorithm that applies...
US20160160220 Methods and Compositions for Treating Autoimmune Disorders by Targeting Kv1.3 Ion Channels with Functionalized Lipid-Derived Nanovesicles  
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased...
9357970 Apparatuses and methods for neurological status evaluation using electromagnetic signals  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
US20160144203 Ultrasound-Mediated Inducement, Detection, and Enhancement of Stable Cavitation  
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes...
9320472 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Apparatuses and methods for neurological status evaluation using electromagnetic signals
 
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
9314014 Compositions and methods for the storage of red blood cells  
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a...
US20160101188 NOVEL NANOCARRIER DELIVERED CANCER CHEMOTHERAPEUTIC AGENTS  
Compositions and methods for treating cancer in a subject are described herein. The composition includes modified nucleobases and nucleosides that are converted in the cell to nucleotides that are...
9297013 pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles  
Trifurcate RNA junction domains derived from phi29 pRNA are described that assemble with high affinity and that are stable in vitro and in vivo. Further expansion of trifurcated RNA domains to...
US20160083353 SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS  
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also...
9266941 Apolipoprotein AIV as an antidiabetic peptide  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20160041105 Optical Sensor  
An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition...
US20160024551 MULTI-TIERED, HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM  
A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each...
US20160008305 TREATMENT OF A DIASTOLIC CARDIAC DYSFUNCTION WITH A TRPV2 RECEPTOR AGONIST  
Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor...
9233099 Methods of treating cognitive dysfunction by modulating brain energy metabolism  
Methods for treating cognitive dysfunction by modulating brain energy metabolizm using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed.
9216171 Methods of preventing ischemic injury using peripheral nociceptive stimulation  
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and...
9211490 Electrofluidic textiles and cleaning implements using such electrofluidic textiles  
The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting,...
US20150344955 METHODS FOR DETECTION AND QUANTIFICATION OF EGFRvIII IN THE PERIPHERAL BLOOD OF GBM PATIENTS  
Methods and kits for detection and quantification of EGFRvIII in the peripheral blood for monitoring the therapy of a GBM patients.
9200037 Compounds for control of appetite  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs...