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Patents and Patent Applications from University of Cincinnati


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8693081 Electrofluidic imaging film, devices, and displays, and methods of making and using the same  
A device and method of making and using the same. The device includes first and second substrates that are spaced to define a fluid space. Polar and non-polar fluids occupy the fluid space. A first...
8685368 Polyamides for nucleic acid delivery  
A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without...
8673844 Method of inhibiting progression of type 1 diabetes by administering soluble CD137  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20140054067 PRESSURE RECONFIGURED ELECTROMAGNETIC DEVICES  
A reconfigurable electromagnetic device includes a first and second planar layer having facing surfaces. One of the surfaces includes one or more micro-trenches. The area between the two surfaces...
US20140030150 FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS  
A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic...
US20140018385 Identification Of PCNA Targeting Compounds For Cancer Therapy And PCNA Function Regulation  
Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include...
US20140005107 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20130344763 Methods for Electrospinning Hydrophobic Coaxial Fibers into Superhydrophobic and Oleophobic Coaxial Fiber Mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
8600069 Multi-channel active noise control system with channel equalization  
A multiple error filtered-x least mean square (MEFxLMS) algorithm using a channel equalization virtual secondary path for an active noise control/cancellation (ANC) system for treating noise in a...
8563328 Fiber-optic biosensor and biosensing methods  
A method for biosensing that includes passing, via convective flow, a sample believed to contain one or more target biomarkers through a microfluidic channel and over the surface of an optical...
8557300 Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite  
Methods for treating bacterial respiratory tract infections in an individual comprise administering a therapeutic amount of nitrite composition having a pH of less than 7, and in specific...
US20130239467 METHOD OF EXTRACTING LIPIDS FROM TRAP GREASE WITH WASTE COOKING OIL  
Describe are methods of extracting the lipid fraction from trap grease using vegetable oil, such as vegetable oils sourced from waste cooking oil. The method includes mixing a volume of vegetable...
US20130233081 EMBEDDED OR CLIP-ON DEVICE FOR HEALTH MONITORING OF AN ARTICLE  
A sensor (10, 80) for monitoring health of an associated article (A) (e.g., a fluid connector) including a sensing element (12, 84, 86) disposed along a length of an outer surface of the associated...
8530160 G-protein coupled receptor kinase-5 polymorphism  
The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of...
US20130230542 ROS-Activated Compounds as Selective Anti-Cancer Therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer...
8527223 Methods and systems for energy prognosis  
In one embodiment, a method for managing an industrial process wherein a processor transforms electronic data into an energy prognosis is provided. An energy related test signal including effective...
8524683 Method for decreasing cardiac using a nucleic acid molecule encoding a variant phosphatase inhibitor-1  
The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (I-1). In particular, the I-1 mutant forms comprise altered phosphorylation sites of...
8518320 Methods for electrospinning hydrophobic coaxial fibers into superhydrophobic and oleophobic coaxial fiber mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
US20130215492 ELECTROWETTING DEVICES ON FLAT AND FLEXIBLE PAPER SUBSTRATES  
Electro wetting devices and methods. The electro wetting device 10 includes a grounded electrode 14 on one side of a paper substrate 12. A dielectric layer 16 and a hydrophobic film 20 are...
US20130214677 Nearly Index-Matched Luminescent Glass-Phosphor Composites For Photonic Applications  
A light emitting device is described. The light emitting device includes a base; a light emitting diode supported by the base; a first layer spaced apart from the light emitting diode and including...
US20130203769 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC, or upstream or...
8501478 Trehalose click polymers for delivery of biologically active molecules  
Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click...
US20130189276 METHOD INHIBITING CELL PROLIFERATION INDUCED BY ALTERNATIVELY SPLICED TISSUE FACTOR  
Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration...
US20130186399 ACOUSTIC PRESSURE INDUCERS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA  
Acoustic pressure inducers and methods for treating obstructive sleep apnea are disclosed. In one embodiment, an acoustic pressure inducer includes an actuator housing having an orifice, a tube...
US20130183743 Microbial Fuel Cell  
Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be...
8484048 Automated system and method for prioritization of waiting patients  
The present invention provides an automated triage system performs a computerized method that includes the steps of: (1) for plurality of patients, gathering medical factor(s) associated with each...
US20130134992 SENSOR SLEEVE FOR HEALTH MONITORING AN ARTICLE  
A sensor sleeve (10) for use in detecting a failure in an article (18) (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer (12) that separates two electrode layers (14, 16). As...
8450364 Use of equol for treating androgen mediated diseases  
Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in...
8450108 Surgical device for skin therapy or testing  
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin,...
8449657 Continuous droplet generator devices and methods  
Continuous droplet generators and methods are provided. In one embodiment, a continuous droplet generator includes an outer housing that defines a working liquid reservoir configured to maintain a...
8435627 Multifunctional nanocoatings with mixed nanoparticles and process for fabricating same  
Embodiments of a coated substrate comprise a substrate (100) with a multi-functional multi-layer nanoparticle coating (105) having a thickness of up to about 500 nm thereon. The nanoparticle...
US20130101610 Therapeutic Uses of CD137 in Treating Autoimmune Disease  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20130095503 SERUM SPLA2-IIA AS DIAGNOSIS MARKER FOR PROSTATE AND LUNG CANCER  
Kits for assessing lung cancer in patients with solitary pulmonary nodules and methods for assessing lung cancer. The kit includes reagents for detection and/or quantification of serum secretory...
US20130092543 ELECTROFLUIDIC TEXTILES AND CLEANING IMPLEMENTS USING SUCH ELECTROFLUIDIC TEXTILES  
The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting,...
8420616 MAT II beta subunit RNAi and therapeutic methods using same  
The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods and...
US20130073223 Turbine-To-Turbine Prognostics Technique For Wind Farms  
Methods and systems for predicting an end of life of a wind turbine component including receiving environmental conditions indicative of natural surroundings of wind turbines within a wind turbine...
8387724 Rotary drill bit with nozzles designed to enhance hydraulic performance and drilling fluid efficiency  
A rotary drill bit having one or more fluid nozzles is provided. Each nozzle may include interior surfaces designed to optimize hydraulic performance and efficiency of fluid flowing through the...
US20130053824 Handheld Devices For Dilating Tissue  
Embodiments of handheld devices for dilating tissue along the paranasal sinuses include a handle assembly that includes a grip portion, an inflation mechanism, and a digital actuation member...
US20130046021 METHODS OF TREATING CARDIOMYOPATHY, SYSTOLIC CARDIAC DYSFUNCTION AND THE SYMPTOMS OF CONGESTIVE HEART FAILURE WITH PROBENECID  
Described herein are inventions is directed to methods of treating a cardiac dysfunction and symptoms of cardiac dysfunction in a subject that includes administering an amount of probenecid...
8372966 Oligonucleotide decoys and methods of use  
The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers...
8354267 Microbial fuel cell  
Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be...
US20120296512 METHOD AND SYSTEM FOR ELECTRIC VEHICLE BATTERY PROGNOSTICS AND HEALTH MANAGEMENT  
A system for managing mobility of an electrically-powered vehicle. The system includes a monitoring module comprising a plurality of sensors. Each of the plurality of sensors is configured to sense...
8308927 Electrofluidic textiles and cleaning implements using such electrofluidic textiles  
The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting,...
US20120276552 SERUM SPLA2-IIA AS DIAGNOSIS MARKER FOR PROSTATE AND LUNG CANCER  
Methods for diagnosing prostate cancer and lung cancer are disclosed. The methods include obtaining a biological sample from a subject, determining a level of serum secretory phospholipase A2-IIA...
8301406 Methods for prognosing mechanical systems  
A method of prognosing a mechanical system to predict when a failure may occur is disclosed. Measurement data corresponding to the mechanical system is used to extract one or more features by...
US20120271167 Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same  
Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include...
US20120270927 Polyamides For Nucleic Acid Delivery  
A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without...
8279166 Display apparatus comprising electrofluidic cells  
A display apparatus is described comprising a plurality of electrofluidic chromatophore (EFC) pixel cells. Each pixel cell comprises a fluid holder for holding a polar fluid and a non-polar fluid...
8278060 Use of VEGF-D in the diagnosis of lymphangioleiomyomatosis (LAM) disease  
Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided.
US20120245211 Methods of Treating Cognitive Dysfunction by Modulating Brain Energy Metabolism  
Methods for treating cognitive dysfunction by modulating brain energy metabolism are discussed.