Patents and Patent Applications from University of Cincinnati


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9868938 Methods for accelerated and enhanced cardiac differentiation of IPS cells by electrical stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...
9868786 Methods for suppressing allergic reactions  
Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid...
US20180000837 METHODS AND COMPOSITIONS FOR SUPPRESSING IGE-MEDIATED ANAPHYLAXIS  
Methods for suppressing IgE-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the...
US20170372480 Systems, Media, and Methods for Pre-Processing and Post-Processing in Additive Manufacturing  
Systems, methods, and media for pre-processing and post-processing in additive manufacturing are provided. A method includes receiving object geometry data. The method may further include...
9850705 Energy efficient shading systems for windows  
A shading assembly configured to have a first selectable state that is transmissive to more than 40% of solar light and reflects more than 35% of solar heat, a second selectable state that blocks...
US20170365094 Localized Contour Tree Method for Deriving Geometric and Topological Properties of Complex Surface Depressions Based on High Resolution Topographical Data  
Computer-implemented methods for detecting and characterizing surface depressions in a topographical landscape based on processing of high resolution digital elevation model data according to a...
US20170363563 CARBON NANOTUBE BASED REFERENCE ELECTRODES AND ALL-CARBON ELECTRODE ASSEMBLIES FOR SENSING AND ELECTROCHEMICAL CHARACTERIZATION  
A carbon nanotube-based reference electrode and an all-carbon nanotube microelectrode assembly for electrochemical sensing and specialized analytics are disclosed, along with methods of...
9845243 Composite catalyst and method for manufacturing carbon nanostructured materials  
A method of forming a carbon nanotube array substrate is disclosed. One embodiment comprises depositing a composite catalyst layer on the substrate, oxidizing the composite catalyst layer,...
US20170358400 GRAPHENE PAPER AND A PROCESS FOR MAKING GRAPHENE PAPER AND A GRAPHENE ELECTRODE  
Described are processes for making graphene pellet (GP) with a three-dimensional structure. The process includes forming a nickel pellet from nickel powder to function as a catalyst for graphene...
US20170357086 ELECTROFLUIDIC DISPLAY AND METHODS FOR MAKING  
A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters...
US20170355998 Methods and Compositions for Treating Autoimmune Disorders by Targeting Kv1.3 Ion Channels with Functionalized Lipid-Derived Nanovesicles  
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased...
US20170354808 ENHANCED ANALYTE ACCESS THROUGH EPITHELIAL TISSUE  
A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an...
US20170349553 SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS  
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also...
9837065 Variable bandwidth delayless subband algorithm for broadband active noise control system  
An active noise control (ANC) system includes a speaker and one or more processors programmed to implement a delayless subband filtered-x least mean square control algorithm. The algorithm...
9834580 Pharmaceutical compositions comprising selective peptide-based agonists of melanocortin 1 receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are...
US20170342165 COMPOSITIONS AND METHODS FOR TREATING COCAINE-RELATED DISORDERS  
Methods for treating a cocaine-related disorder in an individual de administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a...
US20170340715 Materials and Methods Useful For Treating Glioblastoma  
The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when...
9821063 Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators specifically formulated for enhanced inhibition of bacterial colonization and antibacterial efficacy  
Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm...
US20170308672 METHODS FOR DETERMINING RISK AND TREATING DISEASES AND CONDITIONS THAT CORRELATE TO WEATHER DATA  
Methods and model equations are provided for predicting a risk of a subject who experiences adverse medical events associated with the weather, of experiencing a new-onset event. Methods include...
9796121 Methods of growing carbon nanotubes and forming a carbon nanotube thread  
A method of forming an array of aligned, uniform-length carbon nanotubes on a planar surface of a substrate employing a composite catalyst layer of iron and cobalt. The carbon nanotubes have...
9795618 Methods and compositions for suppressing IgE-mediated anaphylaxis  
Methods for suppressing IgE-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the...
US20170295776 RED BLOOD CELL STORAGE SOLUTIONS, SOLUTION ADDITIVES, AND METHODS FOR IMPROVING THE STORAGE OF RED BLOOD CELLS  
Methods, additive kits and storage compositions for decreasing the deleterious effects of storage on pRBCs, for improving the aging process of stored pRBCs, and for preventing or ameliorating...
US20170292835 MEASURING WALL THICKNESS LOSS FOR A STRUCTURE  
Systems, methods and computer storage mediums accurately measure wall thickness in a region of interest included in complex curved structures. Embodiments of the present disclosure relate to...
US20170281377 METHODS FOR MAKING MAGNESIUM BIODEGRADABLE STENTS FOR MEDICAL IMPLANT APPLICATIONS  
Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic...
9777279 Methods and compositions for treating autoimmune disorders by targeting Kv1.3 ion channels with functionalized lipid-derived nanovesicles  
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased...
US20170274043 Therapeutic Uses of CD137pos Regulatory T Cells in Treating Autoimmune Diseases  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20170274042 Pharmaceutical Compositions Comprising Soluble CD137  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
9758593 Compositions and methods for treating cocaine-related disorders  
Methods for treating a cocaine-related disorder in an individual include administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and...
9757432 Materials and methods useful for treating glioblastorna  
The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when...
9753273 Electrofluidic display and methods for making  
A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters...
9751765 Methods to superheat carbon nanotubes  
A method for annealing multi-walled carbon nanotubes includes applying a high-frequency electromagnetic field to the carbon nanotubes and causing the carbon nanotubes to self-heat to a temperature...
US20170248035 ENHANCED DRY-COOLING SYSTEM AND METHOD FOR INCREASING POWER PLANT EFFICIENCY AND OUTPUT  
The presently disclosed subject matter relates to enhanced dry-cooling systems and methods. More specifically, the presently disclosed subject matter relates to enhanced dry-cooling systems for...
US20170245788 SWEAT SENSING WITH ANALYTICAL ASSURANCE  
A sweat sensor device (200) with analytical assurance includes at least one sensor (220) for detecting a first analyte, and at least one calibration medium (270) containing at least the first...
US20170239386 MAGNESIUM SINGLE CRYSTAL FOR BIOMEDICAL APPLICATIONS AND METHODS OF MAKING SAME  
A biomedical implant (16, 18) is formed from magnesium (Mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. The biomedical implant (16, 18) may be post treated to...
9732235 Corrosion resistant hybrid silanized epoxy ester resins, coatings and surface pre-treatment formulations  
A self-healing coating composition for use on metals includes a polyurea, an epoxy ester unsaturated resin, a combination of amine terminated siloxane and epoxy terminated siloxane and an...
9730980 Method of treating type I diabetes using apolipoprotein A-IV  
Methods for treating type one diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type one diabetes mellitus are disclosed, including combination...
US20170199373 DOSING AND SEALING OF FLUID-BASED ELECTRO-OPTICAL DEVICES AND DISPLAYS  
A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate;...
9689671 Measuring wall thickness loss for a structure  
Systems, methods and computer storage mediums accurately measure wall thickness in a region of interest included in complex curved structures. Embodiments of the present disclosure relate to...
US20170172484 COMBINATORIAL SENSING OF SWEAT BIOMARKERS USING POTENTIOMETRIC AND IMPEDANCE MEASUREMENTS  
A wearable sweat sensor device (1) may include a plurality of sensors (150, 160, 170, 180) capable of measuring a plurality of ion-selective biomarker potentials and a mechanism that analyzes a...
9682066 Methods of treating primary brain tumors by administering letrozole  
The present disclosure relates to the field of cancer treatment, and more specifically to the field of treatment of primary malignant brain tumors. Provided herein are methods of treating primary...
9678072 Synthetic ligands for the differentiation of closely related toxins and pathogens  
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1...
9675820 Ultrasound-mediated inducement, detection, and enhancement of stable cavitation  
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes...
US20170162881 MULTI-FUNCTIONAL POROUS CARBON-SUPPORTED MICROPOROUS INORGANIC MEMBRANES FOR REDOX FLOW BATTERIES  
A separator for a redox flow battery includes a support layer having a first side, and a zeolite layer formed on the first side of the support layer. The support layer includes a porous substrate...
9669203 Methods of enhancing delivery of drugs using ultrasonic waves and systems for performing the same  
Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include...
9655752 Methods for making magnesium biodegradable stents for medical implant applications  
Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic...
US20170135594 Non-Invasive Detection of Spreading Depolarization Using Scalp Electroencephalography  
Non-invasive electroencephalogram (EEG)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one...
US20170128418 COMPOSITIONS AND METHODS FOR IMPROVING LACTATION  
The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased PTHrP levels, resulting in the...
9625705 Dosing and sealing of fluid-based elctro-optical devices and displays  
A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate;...
US20170100102 ADVANCED SWEAT SENSOR ADHESION, SEALING, AND FLUIDIC STRATEGIES  
A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220)...
US20170100072 SWEAT SENSING DEVICE COMMUNICATION SECURITY AND COMPLIANCE  
The invention addresses confounding difficulties involving continuous sweat analyte measurement. Specifically, the present invention provides: at least one component capable of monitoring whether...