Patents and Patent Applications from University of Cincinnati


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US20170172484 COMBINATORIAL SENSING OF SWEAT BIOMARKERS USING POTENTIOMETRIC AND IMPEDANCE MEASUREMENTS  
A wearable sweat sensor device (1) may include a plurality of sensors (150, 160, 170, 180) capable of measuring a plurality of ion-selective biomarker potentials and a mechanism that analyzes a...
9682066 Methods of treating primary brain tumors by administering letrozole  
The present disclosure relates to the field of cancer treatment, and more specifically to the field of treatment of primary malignant brain tumors. Provided herein are methods of treating primary...
9678072 Synthetic ligands for the differentiation of closely related toxins and pathogens  
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1...
9675820 Ultrasound-mediated inducement, detection, and enhancement of stable cavitation  
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes...
US20170162881 MULTI-FUNCTIONAL POROUS CARBON-SUPPORTED MICROPOROUS INORGANIC MEMBRANES FOR REDOX FLOW BATTERIES  
A separator for a redox flow battery includes a support layer having a first side, and a zeolite layer formed on the first side of the support layer. The support layer includes a porous substrate...
9669203 Methods of enhancing delivery of drugs using ultrasonic waves and systems for performing the same  
Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include...
9655752 Methods for making magnesium biodegradable stents for medical implant applications  
Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic...
US20170135594 Non-Invasive Detection of Spreading Depolarization Using Scalp Electroencephalography  
Non-invasive electroencephalogram (EEG)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one...
US20170128418 COMPOSITIONS AND METHODS FOR IMPROVING LACTATION  
The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased PTHrP levels, resulting in the...
9625705 Dosing and sealing of fluid-based elctro-optical devices and displays  
A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate;...
US20170100102 ADVANCED SWEAT SENSOR ADHESION, SEALING, AND FLUIDIC STRATEGIES  
A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220)...
US20170095233 DEVICES WITH REDUCED SWEAT VOLUMES BETWEEN SENSORS AND SWEAT GLANDS  
A sweat sensor device (400c) for sensing sweat on the skin (12) includes one or more sweat sensors (420) and a volume-reducing component that provides a volume-reduced pathway (480) for sweat...
US20170095184 SWEAT MONITORING AND CONTROL OF DRUG DELIVERY  
The concentration of an administered compound, such as a drug (D), in an organ or a bodily fluid, such as blood, is determined directly through detecting the drug (D) or its metabolites (DM) in...
US20170095183 VERTICAL-FLOW ELECTRONIC BIO-CHEMICAL SENSING DEVICES  
An electronic sweat sensor (300) includes a plurality of porous substrates (310, 312), each porous substrate (310, 312) having an electrically conductive surface (320, 322). The porous substrates...
US20170074893 DEVICES AND METHODS FOR ANALYZING A BLOOD COAGULATION PROPERTY  
A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The...
US20170071210 SILVER NANOPARTICLE-ENHANCED PHOTOSENSITIZERS  
The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle...
9585870 Compositions and methods for improving lactation  
The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased PTHrP levels, resulting in the...
9581629 Sensor sleeve for health monitoring of an article  
A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode...
US20170044680 ADDITIVE MANUFACTURING BY LOCALIZED ELECTROCHEMICAL DEPOSITION  
A method of electrolytic additive manufacturing provides 3-D parts. The method can be used to form parts from particulate material in an electrolytic bath. Metal is electrolytically deposited,...
US20170035425 METHODS FOR PARTIAL DIVERSION OF THE INTESTINAL TRACT  
Devices and methods are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the...
US20170029523 STIMULATION VIA TLR4/MD-2 TO REVERSE TYPE 1 DIABETES  
Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed...
9555109 Method of inhibiting cell proliferation induced by alternatively spliced tissue factor by administering a monoclonal antibody  
Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration...
US20170016899 Methods of Detecting Influenza Virus  
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method...
US20160376654 Temporal Pediatric Sepsis Biomarker Risk Model  
Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses...
US20160376447 CORROSION RESISTANT HYBRID SILANIZED EPOXY ESTER RESINS, COATINGS AND SURFACE PRE-TREATMENT FORMULATIONS  
A self-healing coating composition for use on metals includes a polyurea, an epoxy ester unsaturated resin, a combination of amine terminated siloxane and epoxy terminated siloxane and an...
9526514 Patient-specific assemblies, jigs, and methods for a personalized total hip arthroplasty system  
A patient-specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant...
9506855 Method and system for analyzing a colorimetric assay  
Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in...
9487816 Methods of detecting influenza virus  
Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method...
US20160318849 Hydrogen Peroxide-Activated Compounds as Selective Anti-Cancer Therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of hydrogen peroxide and are therefore selective anti-cancer therapeutics for...
9476149 Methods for electrospinning hydrophobic coaxial fibers into superhydrophobic and oleophobic coaxial fiber mats  
Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a...
US20160278653 APPARATUSES AND METHODS FOR NEUROLOGIC STATUS EVALUATION USING ELECTROMAGNEITC SIGNALS  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
US20160266100 Enhanced Capture of Magnetic Microbeads in Microfluidic Devices Using Sequentially Switched Electroosmotic Flow  
Methods of increasing the capture efficiency of a microfluidic device for a target reagent, without additional complications to the design of existing microfluidic devices, and more particularly...
US20160263151 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL INFECTION  
Compositions and methods of utilizing the same are provided for treating bacterial infections. The compositions comprise acidified nitrite in combination with an iron chelator and an antibiotic....
US20160257734 ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
9434764 Skin care compositions and methods comprising selective agonists of melanocortin 1 receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin...
US20160250252 BIOACTIVE GAS-ENCAPSULATED ECHOGENIC LIPOSOMES AND METHODS FOR TREATING CARDIOVASCULAR DISEASE  
Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio...
US20160237989 VERTICAL AXIS WIND TURBINES AND RELATED METHODS OF BRAKING  
An exemplary vertical axis wind turbine includes a support structure rotatable about a vertical turbine axis, and at least two blades each operatively coupled to the support structure and...
US20160236938 METHODS TO SUPERHEAT CARBON NANOTUBES  
A method for annealing multi-walled carbon nanotubes includes applying a high-frequency electromagnetic field to the carbon nanotubes and causing the carbon nanotubes to self-heat to a temperature...
9409975 Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
US20160220146 Water and Salt Resistant Solid Super-Acid Catalysts  
Methods for preserving catalytic activity of a PSA polymer membrane in a humid environment by immobilizing in the membrane an organic acid having a pKa greater than the pKa of the PSA polymer...
9394343 Appetite stimulating protein  
An engineered polypeptide comprising an AgRP analog with increased basic residues compared to the wild type polypeptide, wherein the polypeptide, when introduced into the CNS of a mammal,...
9394233 ROS-activated compounds as selective anti-cancer therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer...
US20160201035 Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...
9387066 Elements for versatility of a prosthetic anchor  
A prosthetic anchor to be attached to a natural or prosthetic structure of a human or animal. The anchor includes a central layer with first and second surface. A plurality of fiber bundles, each...
US20160193190 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or...
US20160163305 Variable Bandwidth Delayless Subband Algorithm For Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors programmed to implement a delayless subband filtered-x least mean square control algorithm. The algorithm...
US20160163304 Subband Algorithm With Threshold For Robust Broadband Active Noise Control System  
An active noise control (ANC) system includes a speaker and one or more processors. The one or more processors implement an adaptive subband filtered reference control algorithm that applies...
US20160160220 Methods and Compositions for Treating Autoimmune Disorders by Targeting Kv1.3 Ion Channels with Functionalized Lipid-Derived Nanovesicles  
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased...
9357970 Apparatuses and methods for neurological status evaluation using electromagnetic signals  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
US20160144203 Ultrasound-Mediated Inducement, Detection, and Enhancement of Stable Cavitation  
Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes...