Patents and Patent Applications from University of Cincinnati


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US20180296578 MODULATING PHOSPHATASE ACTIVITY IN CARDIAC CELLS  
Expression of a phosphatase inhibitor in heart cells can be used to treat cardiac disorders, e.g., heart failure. Decreasing phosphatase activity can improve β-adrenergic responsiveness.
US20180295840 SILVER NANOPARTICLE-ENHANCED PHOTOSENSITIZERS  
The present invention relates generally to compositions and methods of killing fungi using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle...
US20180289296 DEVICES CAPABLE OF FLUID SAMPLE CONCENTRATION FOR EXTENDED SENSING OF ANALYTES  
The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the...
10096154 Localized contour tree method for deriving geometric and topological properties of complex surface depressions based on high resolution topographical data  
Computer-implemented methods for detecting and characterizing surface depressions in a topographical landscape based on processing of high resolution digital elevation model data according to a...
US20180286505 DRUG DOSAGE ALERTS AND RELATED METHODS AND MEDIA  
Some embodiments of the invention include computer implemented methods for generating dosage alert values for a drug. Some embodiments include dosage alert values xmin and ymin for a drug, as...
10086005 Methods for suppressing allergic reactions  
A method of treating a subject suffering from an allergic disorder is provided, the method including inducing rapid desensitization to an allergen, the rapid desensitization effectuated by:...
US20180273589 Neurospora Crassa Strains with Amplified Expression of Cellulases and Production of Biofuel Therefrom  
Transgenic strains of Neurospora crassa engineered to comprise a synthetic positive feedback loop for a transcriptional activator of cellulase expression such that cellulase production is...
US20180264473 MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES  
A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14)...
US20180259517 METHODS AND COMPOSITIONS FOR THE DETECTION OF FC RECEPTOR BINDING ACTIVITY OF ANTIBODIES  
Disclosed are kits and methods for determining the presence or absence of an antibody of interest in a biological sample of a subject. In particular, the methods may detect either pathological or...
10071954 Hydrogen peroxide-activated compounds as selective anti-cancer therapeutics  
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of hydrogen peroxide and are therefore selective anti-cancer therapeutics for...
10071134 Therapeutic uses of CD137pos regulatory T cells  
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of...
US20180245155 Compositions and Methods for Identifying Genetic Predisposition to Obesity and for Enhancing Adipogenesis  
The present invention provides compositions and methods for identifying a subject as having a genetic predisposition to obesity or at risk of developing obesity. The present invention also...
US20180242971 Arteriovenous Fistula Implant Effective for Inducing Laminar Blood Flow  
A vascular implant device configured to decrease turbulence in blood flow through an arteriovenous fistula is described. The implant includes an arterial section having a straight hollow tube, a...
US20180235522 MECHANICALLY CO-LOCATED SWEAT STIMULATION AND SENSING  
The disclosed invention provides a sweat sensor device capable of high performance stimulation and sensing at the same site on the skin, by mechanically co-locating the sensing and stimulation...
US20180230229 STIMULATION VIA TLR4/MD-2 TO REVERSE TYPE 1 DIABETES  
Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed...
US20180214137 DEVICES FOR INTEGRATED, REPEATED, PROLONGED, AND/OR RELIABLE SWEAT STIMULATION AND BIOSENSING  
A sweat sensing device includes a plurality of sweat collection pads communicating with a sensor. Each of the pads is activated by a timing circuit which allows one or more of the pads to be...
US20180208992 CpG ISLAND METHYLATION PROFILE IN NON-INVASIVE ORAL RINSE SAMPLES FOR DETECTION OF ORAL AND PHARYNGEAL CARCINOMA  
There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection and palpation. Described is an improve method of detecting oral and pharyngeal cancer...
US20180169120 COMBINATION THERAPY INCLUDING SAPC-DOPS FOR THE TREATMENT OF PANCREATIC CANCER  
Disclosed herein, according to the present invention, are methods of treating pancreatic cancer comprising administering a first pharmaceutical composition comprising Saposin C and...
9999225 Silver nanoparticle-enhanced photosensitizers  
The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle...
US20180164282 METHODS OF DIAGNOSING CLOSTRIDIUM DIFFICILE INFECTION OR RECURRENCE IN A SUBJECT  
Methods are described for identifying CDI patients as well as CDI patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (PBMC)...
9987632 Microfluidic methods for passive separation of cells and particles  
A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14)...
US20180148692 Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...
US20180125395 AUGMENTED NEUROMUSCULAR TRAINING SYSTEM AND METHOD  
An augmented neuromuscular training system and method for providing feedback to a user in order to reduce movement deficits associated with injury risk, prior injury or disease pathology.
US20180119232 GRADING, STAGING, AND PROGNOSING CANCER USING OSTEOPONTIN-C  
The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade,...
US20180119150 Methods for Treating Acute Myeloid Leukemia and Nanoparticle Complexes of miR-22 Utilized Therein  
Compositions and methods for treating acute myeloid leukemia (AML) based on upregulating expression of microRNA-22 (miR-22), and a nanoparticle delivery system that utilizes FLT3-functionalized...
US20180117015 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or...
9957332 Compositions and methods for treating cocaine-related disorders  
A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human...
9951120 Method of treating diabetes using non-glycosylated apolipoprotein A-IV  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed, wherein the methods and...
9951024 Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors  
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also...
US20180100025 Compositions and Methods for Treating Cocaine-Related Disorders  
A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human...
US20180099109 Smart Oxygenation System Employing Automatic Control Using SpO2-to-FiO2 Ratio  
A system for assessing lung function in a patient is enclosed. The oxygen delivery system in the system (e.g., a ventilator or portable standalone system) preferably includes an oximeter sensor...
9938348 Stimulation via TLR4/MD-2 to reverse type 1 diabetes  
Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed...
US20180092929 Methods for Suppressing Allergic Reactions  
A method of treating a subject suffering from an allergic disorder is provided, the method including inducing rapid desensitization to an allergen, the rapid desensitization effectuated by:...
US20180085047 AUTOMATED DETECTION OF SPREADING DEPOLARIZATIONS  
Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of...
9925206 Compositions and methods for treating bacterial infection  
Compositions and methods of utilizing the same are provided for treating bacterial infections. The compositions comprise acidified nitrite in combination with an iron chelator and an antibiotic....
9921167 Optical sensor based on PFSI membrane comprising associated benzene-1,3-diol for detecting target compounds, and method thereof  
An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition...
9920113 Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
US20180066016 Pharmaceutical Compositions and Therapeutic Methods of Use Comprising Selective Agonists of Melanocortin 1 Receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are...
9911985 Inorganic microporous ion exchange membranes for redox flow batteries  
A composite structure comprising a layer of zeolite having a high silica to alumina ratio supported on a support layer acts as a separator in a redox flow battery. The zeolite can be either...
US20180049681 METHODS AND MATERIALS FOR PROLONGED SWEAT STIMULATION  
A method for stimulating and sensing sweat includes dosing a sweat stimulant to skin effective to generate sweat at a generation rate of at least 0.1 nL/min/gland for a duration of six hours or...
9895363 Methods for modulating function of proliferating cell nuclear antigen (PCNA) and treating cancer with PCNA-targeting compounds  
Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include...
US20180044738 METHOD OF DIAGNOSING BREAST CANCER, MONITORING TREATMENT OF BREAST CANCER, AND TREATING BREAST CANCER  
Described are methods of detecting circulating HOTAIR in breast cancer patients. The detection of circulating HOTAIR may aid in the treatment of triple-negative breast cancer (“TNBC”) or...
US20180042841 Echogenic Vehicle for Clinical Delivery of Plasminogen Activator and Other Fibrin-Binding Therapeutics to Thrombi  
We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group...
US20180042585 SWEAT SENSING DEVICES WITH PRIORITIZED SWEAT DATA FROM A SUBSET OF SENSORS  
A sweat sensor device for sensing at least one analyte includes a plurality of sensors for sensing said at least one analyte and for producing data. Data from a subset of said plurality of sensors...
US20180036437 Gas-Encapsulated Acoustically Responsive Stabilized Microbubbles and Methods for Treating Cardiovascular Disease  
Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a...
US20180036410 Antimicrobial Compositions of Aminoglycosidic Antibiotics and Zinc Ion Chelators Specifically Formulated for Enhanced Inhibition of Bacterial Colonization and Antibacterial Efficacy  
Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm...
US20180035928 DEVICES FOR INTEGRATED INDIRECT SWEAT STIMULATION AND SENSING  
A sweat sensing device includes at least one sweat generation unit capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit...
US20180031942 TWO PARTICLE ELECTROPHORETIC LAMINATE FOR USE WITH SMART WINDOWS WITH REDUCED DIFFRACTION  
A laminate which can serve as either a smart window or a smart mirror is formed using first and second substrates coated with transparent first and second electrodes which are separated by...
9873915 Grading, staging and prognosing cancer using osteopontin-C  
The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade,...
9868938 Methods for accelerated and enhanced cardiac differentiation of IPS cells by electrical stimulation  
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from iPSCs...