Patents and Patent Applications from University of Cincinnati


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9320472 Apparatuses and methods for neurological status evaluation using electromagnetic signals  
In one embodiment, a neurological status evaluation apparatus includes a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna...
9314014 Compositions and methods for the storage of red blood cells  
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a...
US20160101188 NOVEL NANOCARRIER DELIVERED CANCER CHEMOTHERAPEUTIC AGENTS  
Compositions and methods for treating cancer in a subject are described herein. The composition includes modified nucleobases and nucleosides that are converted in the cell to nucleotides that are...
9297013 pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles  
Trifurcate RNA junction domains derived from phi29 pRNA are described that assemble with high affinity and that are stable in vitro and in vivo. Further expansion of trifurcated RNA domains to...
US20160083353 SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS  
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also...
9266941 Apolipoprotein AIV as an antidiabetic peptide  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20160041105 Optical Sensor  
An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition...
US20160024551 MULTI-TIERED, HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM  
A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each...
US20160008305 TREATMENT OF A DIASTOLIC CARDIAC DYSFUNCTION WITH A TRPV2 RECEPTOR AGONIST  
Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor...
9233099 Methods of treating cognitive dysfunction by modulating brain energy metabolism  
Methods for treating cognitive dysfunction by modulating brain energy metabolizm using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed.
9216171 Methods of preventing ischemic injury using peripheral nociceptive stimulation  
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and...
9211490 Electrofluidic textiles and cleaning implements using such electrofluidic textiles  
The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting,...
US20150344955 METHODS FOR DETECTION AND QUANTIFICATION OF EGFRvIII IN THE PERIPHERAL BLOOD OF GBM PATIENTS  
Methods and kits for detection and quantification of EGFRvIII in the peripheral blood for monitoring the therapy of a GBM patients.
9200037 Compounds for control of appetite  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs...
9180454 Electrowetting and electrofluidic devices with laplace barriers and related methods  
Electrowetting and electrofluidic devices and methods. The device includes a hydrophobic channel formed between first and second substrates and a polar fluid and a non-polar fluid contained in the...
US20150309099 SENSOR SLEEVE FOR HEALTH MONITORING OF AN ARTICLE  
A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode...
US20150309022 Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens  
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1...
US20150306189 Compositions and Methods for Inducing Liver Regeneration by Administering Hepatocyte-Derived Exosomes  
A pharmaceutical composition containing (1) a therapeutically effective amount of hepatocyte-derived exosomes; and (2) a pharmaceutically-acceptable carrier is provided. Also provided herein is a...
US20150299251 Skin Care Compositions and Methods Comprising Selective Agonists of Melanocortin 1 Receptor  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin...
US20150297667 PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS OF USE COMPRISING SELECTIVE AGONISTS OF MELANOCORTIN 1 RECEPTOR  
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are...
US20150293347 ELECTROFLUIDIC DISPLAY AND METHODS FOR MAKING  
A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters...
US20150293346 DOSING AND SEALING OF FLUID-BASED ELECTRO-OPTICAL DEVICES AND DISPLAYS  
A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate;...
US20150292023 Materials and Methods Related to NSAID Chemoprevention in Colorectal Cancer  
Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In...
US20150290300 Materials and Methods Useful for Treating Glioblastoma  
The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when...
US20150283005 DEVICES AND METHODS FOR DIRECTING A MEDICAL FABRIC INTO A PORTION OF THE BODY  
A device (10) for directing a medical fabric (28) into a portion of a body. An elongated housing (12) having a distal end (16) and an opening (22) at the distal end (16). A supply of medical...
US20150274621 Homogeneous Hydrogenation of Esters Employing a Complex of Iron as Catalyst  
The homogeneous hydrogenation of organic carbonyls, especially esters, under relatively mild conditions using iron hydrido-borohydride catalyst complexes having amino-phosphine pincer ligands. The...
US20150252095 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
US20150246125 Methods and Compositions for Suppressing IgE-Mediated Anaphylaxis  
Methods for suppressing IgE-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the...
9122005 Electrowetting retroreflector devices, systems, and methods  
Switchable retroreflector devices that are modulated via electrowetting. The devices include an electrically-conductive polar fluid and a non-polar fluid that is immiscible with the polar fluid....
9114148 Modulating phosphatase activity in cardiac cells  
Expression of a phosphatase inhibitor in heart cells can be used to treat cardiac disorders, e.g., heart failure. Decreasing phosphatase activity can improve β-adrenergic responsiveness.
9113559 Pressure reconfigured electromagnetic devices  
A reconfigurable electromagnetic device includes a first and second planar layer having facing surfaces. One of the surfaces includes one or more micro-trenches. The area between the two surfaces...
US20150225658 METHOD OF EXTRACTING LIPIDS FROM TRAP GREASE WITH WASTE COOKING OIL  
Describe are methods of extracting the lipid fraction from trap grease using vegetable oil, such as vegetable oils sourced from waste cooking oil. The method includes mixing a volume of vegetable...
9081171 Spectrum-modulated smart windows  
Methods, systems, devices and/or apparatuses are provided that selectively reflect the infrared spectrum independent of other regions of the solar spectrum in order to actively manage solar heat...
US20150182591 METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV  
Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include...
US20150164986 METHOD OF TREATING TYPE I DIABETES USING APOLIPOPROTEIN AIV  
Methods for treating type one diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type one diabetes mellitus are disclosed, including combination...
9051394 Apolipoprotein AIV as an antidiabetic peptide  
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include...
9045516 Synthetic ligands for the differentiation of closely related toxins and pathogens  
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1...
US20150137414 Catalyst Composition and Method for Growing Spinable Carbon Nanotube Arrays  
A method of forming an array of aligned, uniform-length carbon nanotubes on a planar surface of a substrate employing a composite catalyst layer of iron and cobalt. The carbon nanotubes have...
US20150129140 ENERGY EFFICIENT SHADING SYSTEMS FOR WINDOWS  
A shading assembly configured to have a first selectable state that is transmissive to more than 40% of solar light and reflects more than 35% of solar heat, a second selectable state that blocks...
US20150126433 GROWTH FACTORS FOR THE TREATMENT OF MYCOBACTERIAL INFECTION  
Described herein are novel methods and kits for treating mycobacterium infections with KGF. The methods include administering an amount of KGF effective to treat the mycobacterium infection. The...
US20150119437 Methods of Treating Cognitive Dysfunction by Modulating Brain Energy Metabolism  
Methods for treating cognitive dysfunction by modulating brain energy metabolism using cyclocreatine or a pharmaceutically acceptable salt thereof are discussed.
US20150112165 SWEAT SENSING WITH CHRONOLOGICAL ASSURANCE  
Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat...
US20150112164 DEVICES FOR INTEGRATED, REPEATED, PROLONGED, AND/OR RELIABLE SWEAT STIMULATION AND BIOSENSING  
A sweat sensing device includes a plurality of sweat collection pads communicating with a sensor. Each of the pads is activated by a timing circuit which allows one or more of the pads to be...
US20150105854 Methods for Making Magnesium Biodegradable Stents for Medical Implant Applications  
Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic...
US20150080784 METHOD AND DEVICE FOR TREATING A TISSUE WITH A HIGH FREQUENCY ELECTROMAGNETIC FIELD  
Methods and systems for treating a tissue with a high frequency electric field to activate MAPK/ERK pathways, induce angiogenesis, induce angionenic factos such as NO and VEGF, or promote wound...
8980223 Methods of preventing ischemic injury using peripheral nociceptive stimulation  
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and...
US20150059625 LOW EMISSION FUEL PELLET  
Low emission fuel pellets are formed from fuel sources such as non-recyclable paper and plastic materials by combining sorbent(s) to the interior of the pellet as it is being formed or coating the...
8967143 Acoustic pressure inducers and methods for treatment of obstructive sleep apnea  
Acoustic pressure inducers and methods for treating obstructive sleep apnea are disclosed. In one embodiment, an acoustic pressure inducer includes an actuator housing having an orifice, a tube...
US20150057515 SWEAT SIMULATION, COLLECTING AND SENSING SYSTEMS  
Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a...
US20150055134 METHOD AND SYSTEM FOR ANALYZING A COLORIMETRIC ASSAY  
Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in...