Patents and Patent Applications from University of Chicago


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US20170298362 ANTI-TUMOR THERAPY  
Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or...
9790504 Anti-tumor therapy  
Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or...
9782607 Systems and methods for radiation treatment planning using combined imaging and treatment dose  
Systems and methods for radiation treatment planning that integrate the MV therapeutic radiation dose imparted to a subject together with the kV imaging radiation dose imparted to a subject during...
US20170281668 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS  
The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a...
9777271 Antisense polynucleotides to induce exon skipping and methods of treating dystrophies  
Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or...
US20170278687 BATCH PRODUCTION OF MICROCHANNEL PLATE PHOTO-MULTIPLIERS  
In-situ methods for the batch fabrication of flat-panel micro-channel plate (MCP) photomultiplier tube (PMT) detectors (MCP-PMTs), without transporting either the window or the detector assembly...
US20170273954 METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS  
Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic....
US20170268036 OLIGONUCLEOTIDE-MEDIATED QUANTITATIVE MULTIPLEXED IMMUNOASSAYS  
Methods and compositions for quantitative immunoassays are provided, in which ligand-conjugated probes are used to label samples and ligand-surfaced microspheres are used as quantitative reference...
US20170268001 RNAS WITH TUMOR RADIO/CHEMO-SENSITIZING AND IMMUNOMODULATORY PROPERTIES AND METHODS OF THEIR PREPARATION AND APPLICATION  
Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or...
US20170261949 APPARATUS AND METHOD FOR OPTIMIZING QUANTIFIABLE BEHAVIOR IN CONFIGURABLE DEVICES AND SYSTEMS  
An apparatus and method are provided to perform constrained optimization of a constrained property of an apparatus, which is complex due to having several components, and these components are...
US20170261835 SEMICONDUCTOR SYSTEM WITH TRANSITIONAL METAL IMPURITY FOR QUANTUM INFORMATION PROCESSING  
Methods and devices are disclosed for implementing quantum information processing based on electron spins in semiconductor and transition metal compositions. The transition metal electron orbitals...
US20170258909 USE OF OPIOID ANTAGONISTS TO ATTENUATE ENDOTHELIAL CELL PROLIFERATION AND MIGRATION  
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that...
US20170254817 BIOMARKERS IN NASAL EXHALED BREATH  
A method of diagnosing or assessing risk of a tauopathy in a person is disclosed. The method may comprise collecting a nasal sample of exhaled breath from the person's nose, analyzing the nasal...
US20170252336 USE OF OPIOID ANTAGONISTS TO ATTENUATE ENDOTHELIAL CELL PROLIFERATION AND MIGRATION  
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that...
US20170240767 RESIN COMPOSITION FOR FORMING A PHASE-SEPARATED STRUCTURE, AND METHOD OF PRODUCING STRUCTURE CONTAINING PHASE-SEPARATED STRUCTURE  
A resin composition for forming a phase-separated structure, including a block copolymer, and an ion liquid containing a compound having a cation moiety and an anion moiety, the anion moiety being...
US20170240766 RESIN COMPOSITION FOR FORMING A PHASE-SEPARATED STRUCTURE, AND METHOD OF PRODUCING STRUCTURE CONTAINING PHASE-SEPARATED STRUCTURE  
A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (IL) having a cation moiety and an anion moiety, the cation...
US20170232440 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20170231903 NANOPARTICLES FOR PHOTODYNAMIC THERAPY, X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF  
Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays and/or scintillation. Optionally, the photo sensitizer or...
US20170226090 INDOLINE SULFONAMIDE INHIBITORS OF DAPE AND NDM-1 AND USE OF THE SAME  
Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from...
US20170222724 ULTRAFAST ALL-OPTICAL MODULATION OF THE VISIBLE AND INFRARED SPECTRUM WITH NANOROD ARRAYS  
Disclosed herein is a method of optical modulation, the method comprising irradiating an optical switch with a control beam at a first control time and irradiating the optical switch with a signal...
US20170218055 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A  
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for...
US20170216409 MODULATION OF LAMININ ALPHA-4 IN THE PREVENTION, TREATMENT, AND MANAGEMENT OF METABOLIC SYNDROMES  
The disclosure provides methods of preventing or treating metabolic syndrome in a subject by administering an effective amount of an inhibitor of laminin α4 expression, laminin α4 activity, or both.
9717725 Use of opioid antagonists  
Embodiments of the invention provide methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration,...
US20170202832 USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGRESSION  
Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a...
9711201 Reconfigurable and writable magnetic charge crystals  
Artificial ices enable the study of geometrical frustration by design and through direct observation. It has, however, proven difficult to achieve tailored long-range ordering of their diverse...
9701738 Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease  
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for...
9696729 Microfluidic system  
The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
US20170182486 METAL-ORGANIC FRAMEWORKS CONTAINING NITROGEN-DONOR LIGANDS FOR EFFICIENT CATALYTIC ORGANIC TRANSFORMATIONS  
Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were...
US20170182066 METHODS AND COMPOSITIONS RELATED TO GLUCOCORTICOID RECEPTOR ANTAGONISTS AND BREAST CANCER  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other...
9687502 Methods and compositions for treating mammalian nerve tissue injuries  
To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane...
US20170174629 USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING  
The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose...
US20170173572 CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS  
Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then...
US20170166652 Chimeric Antigen Receptors Recognizing Cancer-Specific TN Glycopeptide Variants  
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different...
9675602 Use of opioid antagonists to attenuate endothelial cell proliferation and migration  
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that...
9675592 Methods and compositions for bacteria infections  
Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic....
9675446 Prosthetic implant for medialization thyroplasty  
Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the...
9672638 Spectral X-ray computed tomography reconstruction using a vectorial total variation  
An apparatus and method of reconstructing a computed tomography (CT) image using multiple datasets of projective measurements, wherein the method of image reconstruction favors spatial...
9669036 Modulation of reactivation of a latent virus  
The disclosure relates to methods of controlling the state of a virus (lytic or lysogenic) in an individual, such as a method of reactivating a latent virus in an individual, comprising...
9663818 Oligonucleotide-mediated quantitative multiplexed immunoassays  
Methods and compositions for quantitative immunoassays are provided, in which ligand-conjugated probes are used to label samples and ligand-surfaced microspheres are used as quantitative reference...
9662390 Use of opioid antagonists to attenuate endothelial cell proliferation and migration  
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that...
9662325 Use of opioid antagonists to attenuate endothelial cell proliferation and migration  
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that...
US20170145108 CHIMERIC ANTIGEN RECEPTORS RECOGNIZING CANCER-SPECIFIC TN GLYCOPEPTIDE VARIANTS  
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different...
US20170137484 METHODS AND COMPOSITIONS FOR CANCER THERAPY USING MUTANT LIGHT MOLECULES WITH INCREASED AFFINITY TO RECEPTORS  
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse...
US20170110720 GRAPHENE-COATED METAL OXIDE SPINEL CATHODES  
Disclosed herein are graphene-coated lithium manganese oxide spinels cathodes for high-performance batteries Li-ion batteries and methods for making thereof. A single-layer graphene coating is...
9625588 Use of flat panel microchannel photomultipliers in sampling calorimeters with timing  
Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of...
9623116 Antibody-light fusion products for cancer therapeutics  
Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and...
9623032 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other...
9617215 Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging  
The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose...
9613442 Image reconstruction from limited or incomplete data  
A system and method are provided for reconstructing images from limited or incomplete data, such as few view data or limited angle data or truncated data generated from divergent beams. The method...
9611510 Composition and methods related to modification of 5-methylcytosine (5-mC)  
The present invention relates to methods and compositions for detecting, evaluating, and/or mapping 5-methyl-modified and/or 5-hydroxylmethyl-modified cytosine bases within a nucleic acid molecule.