Patents and Patent Applications from University of Chicago


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US20180104232 METHODS FOR DETERMINING PROGNOSIS FOR BREAST CANCER PATIENTS  
Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a patient determined to be...
9944992 Methods and compositions related to T-cell activity  
Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of...
9944982 Surface chemistry and deposition techniques  
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface...
US20180102660 MATERIALS FOR USE WITH AQUEOUS REDOX FLOW BATTERIES AND RELATED METHODS AND SYSTEMS  
Described herein are redox flow batteries comprising a first aqueous electrolyte comprising a first type of redox active material and a second aqueous electrolyte comprising a second type of redox...
US20180098947 PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE  
Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing...
9937199 Materials and methods for preventing and treating anastomotic leaks  
Materials and methods for preventing and treating anastomotic leaks are disclosed. Data establishes that pathogenic microbes interfere with establishing epithelial cell barriers in anastomoses...
US20180094283 System for the Production of Methane From CO2  
A method of converting CO2 gas produced during industrial processes comprising contacting methanogenic archaea with the CO2 gas under suitable conditions to produce methane.
US20180092761 BIOMIMETIC AND VARIABLE STIFFNESS ANKLE SYSTEM AND RELATED METHODS  
A cam system for an assistive device and related methods are disclosed. The cam system may comprise a cam profile and a cam follower. The cam profile has a curved outer edge comprising a concave...
US20180087016 CHAMBER FOR IMAGING CELLS AND METHOD OF USE THEREOF  
One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a...
9927706 Atomic layer chemical patterns for block copolymer assembly  
Provided herein are methods of directed self-assembly (DSA) on atomic layer chemical patterns and related compositions. The atomic layer chemical patterns may be formed from two-dimensional...
US20180080030 COMPOSITIONS AND METHODS FOR CORRECTING LIMB GIRDLE MUSCULAR DYSTROPHY TYPE 2C USING EXON SKIPPING  
The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients...
US20180073062 COMPOSITIONS AND METHODS FOR IDENTIFYING ENDOGENOUS DNA-DNA INTERACTIONS  
Provided herein are compositions and methods for identifying endogenous DNA-DNA interactions. In particular, compositions and methods are provided for performing Capture of Associated Targets on...
9916958 Alkali semi-metal films and method and apparatus for fabricating them  
Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as,...
9914847 Resin composition for forming a phase-separated structure, and method of producing structure containing phase-separated structure  
A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (IL) having a cation moiety and an anion moiety, the energy of...
US20180066031 ENZYMATICALLY-CLEAVABLE PEPTIDE AMPHIPHILES  
Provided herein are enzymatically-cleavable peptide amphiphiles and methods of use thereof.
US20180066030 MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE  
Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i) having a mutation in the dendritic cell...
9911584 Batch production of microchannel plate photo-multipliers  
In-situ methods for the batch fabrication of flat-panel micro-channel plate (MCP) photomultiplier tube (PMT) detectors (MCP-PMTs), without transporting either the window or the detector assembly...
9907850 Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20180046763 Detection and Visualization of Temporal Events in a Large-Scale Patient Database  
A method for detecting temporal events includes accessing a non-relational database storing patient encounter information for a plurality of encounters and patients. The stored encounter...
US20180046565 AUTOMATICALLY DETECTING DISTRIBUTED CONCURRENCY ERRORS IN CLOUD SYSTEMS  
A method for detecting distributed concurrency errors in a distributed cloud computing system includes tracing operations that access objects in functions involving inter-process messaging,...
US20180044385 METHODS AND COMPOSITIONS INVOLVING PROTEIN G VARIANTS  
Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the Fab region of an antibody. Methods include using the polypeptides for...
9889446 Device and method for pressure-driven plug transport and reaction  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20180038968 POSITRON-EMISSION TOMOGRAPHY DETECTOR SYSTEMS BASED ON LOW-DENSITY LIQUID SCINTILLATORS AND PRECISE TIME-RESOLVING PHOTODETECTORS  
TOF-PET detector systems, and methods for imaging photon-emitting samples using the detector systems, are provided. The TOF-PET detector systems use large-area photodetectors with extremely high...
US20180038868 BETA-CATENIN INHIBITORS IN CANCER IMMUNOTHERAPY  
Provided herein are compositions and methods for the treatment of cancer by inhibition of β-catenin or a β-catenin pathway. In particular, inhibitors of β-catenin and/or the Wnt/p-catenin...
US20180037889 ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHODS OF TREATING DYSTROPHIES  
Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or...
US20180036380 TREATMENTS FOR MIGRAINE AND RELATED DISORDERS  
Embodiments are directed to compositions and methods of treating migraine and related neurological disorders. In certain aspects, methods and compositions are for reducing cortical spreading...
US20180036318 METHODS AND COMPOSITIONS RELATED TO GLUCOCORTICOID RECEPTOR ANTAGONISM AND PROST A TE CANCER  
Methods are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer...
9885050 Molecular affinity clamp technology and uses thereof  
The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first...
US20180028553 USE OF STING AGONIST AS CANCER TREATMENT  
Methods and compositions for treating cancer by intratumorally administering a stimulator of interferon genes (STING) agonist are disclosed herein.
US20180028224 MALLET WITH RADIOLUCENT HEAD  
This disclosure includes embodiments of mallets with radiolucent heads to permit radiologic imaging of a device (e.g., needle) as the device is being positioned with the mallet, as well as methods...
US20180027808 METHODS, FORMULATIONS, AND KITS FOR BACTERIAL DEGRADATION  
Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain and at least one germinant. Methods...
9882001 Materials and methods for the preparation of nanocomposites  
Disclosed herein is an isolable colloidal particle comprising a nanoparticle and an inorganic capping agent bound to the surface of the nanoparticle, a method for making the same in a biphasic...
9877976 Methods and compositions for protection of cells and tissues from computed tomography radiation  
Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of...
9872637 Medical evaluation system and method using sensors in mobile devices  
A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device...
US20180015131 TREATMENT OF CANCER BY MANIPULATION OF COMMENSAL MICROFLORA  
Provided herein are methods of treatment and/or prevention of cancer by manipulation of commensal microflora. In particular, the amount, identity, presence, and/or ratio of microflora (e.g., gut...
US20180008594 USE OF OPIOID ANTAGONISTS  
Embodiments of the invention provide methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration,...
9861619 Antibiotic methods and compositions for bacteria infections  
Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic....
9855302 Treatment of cancer by manipulation of commensal microflora  
Provided herein are methods of treatment and/or prevention of cancer by manipulation of commensal microflora. In particular, the amount, identity, presence, and/or ratio of microflora (e.g., gut...
US20170369847 TISSUES CONTAINING SEMICONDUCTOR NANOMATERIALS AND METHODS OF PREPARING AND USING THE SAME  
Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.
US20170369536 Compositions and Methods Related to Protein A (SpA) Variants  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20170368551 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
9849174 Methods and compositions related to immunogenic fibrils  
Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any...
US20170364101 MICROFLUIDIC SYSTEM  
The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
US20170363607 AMORPHOUS, POROUS SILICON MATERIALS AND RELATED METHODS  
Provided herein are Si-based materials, methods of making the Si-based materials, and methods for using the Si-based materials. In embodiments, a silicon-based material comprises an aggregate of...
US20170362460 RESIN COMPOSITION FOR FORMING A PHASE-SEPARATED STRUCTURE, AND METHOD OF PRODUCING STRUCTURE CONTAINING PHASE-SEPARATED STRUCTURE  
A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (IL) having a cation moiety and an anion moiety, the energy of...
US20170361321 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20170360931 METHODS AND COMPOSITION FOR NEUTRALIZATION OF INFLUENZA  
Provided herein are compositions useful for neutralization of influenza virus, and methods of use and manufacture thereof. In particular, compositions comprising antibodies that are cross-reactive...
US20170355648 SYNTHESIS OF META-SUBSTITUTED [18F]-3-FLUORO-4-AMINOPYRIDINES BY DIRECT RADIOFLUORINATION OF PYRIDINE N-OXIDES  
Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic...
9839893 Device and method for pressure-driven plug transport and reaction  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20170343252 SYSTEMS AND METHODS FOR PROVIDING CONTINUOUS COOLING AT CRYOGENIC TEMPERATURES  
Systems and methods of continuous cooling at cryogenic temperatures. One exemplary aspect involves a refrigeration system that includes: a chamber adapted to hold liquid and gaseous coolant...