Patents and Patent Applications from University of Chicago


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10049772 System and method for creation, operation and use of a clinical research database  
In a method, a user at a client device may be provided with a user interface having user interactive controls, including a control to enable selection from among a plurality of disease groups....
10047377 Methods for modulating KLHL1 levels, methods for modulating current activity in T-type calcium channels, molecules therefor, and methods for identifying molecules therefor  
Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject...
10047149 Compositions and methods related to antibodies to Staphylococcal protein A  
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for...
10036069 Biomarkers for assessing idiopathic pulmonary fibrosis  
Disclosed are methods are kits for evaluating predicting whether an individual IPF has slowly or rapidly progressive IPF.
10034939 Synergistic combination of immunologic inhibitors for the treatment of cancer  
In some embodiments, the methods involve the use of a combination of at least two of the following: an inhibitor of indoleamine-2,3-dioxygenase (IDO), an inhibitor of the PD-L1/PD-1 pathway, an...
US20180208884 METHOD AND SYSTEM FOR CONVERTING ELECTRICITY INTO ALTERNATIVE ENERGY RESOURCES  
A method of using electricity to produce methane includes maintaining a culture comprising living methanogenic microorganisms at a temperature above 50° C. in a reactor having a first chamber and...
US20180208678 METHODS AND COMPOSITION FOR MODIFYING ENZYMES  
Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies...
US20180201937 INHIBITORS OF CACNA1A/ALPHA1A SUBUNIT INTERNAL RIBOSOMAL ENTRY SITE (IRES) AND METHODS OF TREATING SPINOCEREBELLAR ATAXIA TYPE 6  
The invention provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject an IRES inhibitor in an amount...
US20180193838 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20180193837 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20180193363 METHODS AND COMPOSITIONS FOR PROTECTION OF CELLS AND TISSUES FROM COMPUTED TOMOGRAPHY RADIATION  
Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of...
10017765 Inhibitors of CACNA1A/ALPHA1A subunit internal ribosomal entry site (IRES) and methods of treating spinocerebellar ataxia type 6  
The disclosure provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject an IRES inhibitor in an amount...
US20180179574 SYSTEMS AND METHODS FOR CHARACTERIZATION OF HYPERTRIGLYCERIDEMIA  
Provided herein are systems (e.g., reagents, devices, etc.) and methods for characterization of hypertriglyceridemia (HTG) in a subject. In particular, systems and methods, are provided for...
US20180170992 CAR T CELLS RECOGNIZING CANCER-SPECIFIC IL 13Ra2  
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13Rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy...
US20180154362 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20180153796 NANOPARTICLES FOR PHOTODYNAMIC THERAPY, X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RADIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF  
Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation....
9991444 Surface-modified organic semiconductors  
Surface-modified organic semiconductors and methods for making surface-modified organic semiconductors are disclosed. More particularly, surface-modified thin films are provided, the...
US20180147250 SYNTHETIC SUBSTRATES FOR ENZYMES THAT CATALYZE REACTIONS OF MODIFIED CYSTEINES AND RELATED METHODS  
Synthetic probes for detecting the activity of enzymes that catalyze reactions of post-translationally modified cysteine residues are described. The probes include “turn-on” probes that include a...
US20180144934 COMPOSITIONALLY MATCHED MOLECULAR SOLDERS FOR SEMICONDUCTORS  
Chalcogenidometallates of group IIB, IV and V elements and, particularly, alkali metal-containing chalcogenidometallates of cadmium, lead and bismuth are provided. Also provided are methods of...
US20180144469 REPORTING TOOL WITH INTEGRATED LESION STAGER  
A device and method integrates a lesion stager in a reporting tool. The method includes receiving a user input. The user input is image data including at least one variable value. The variable...
US20180140265 RADIATION THERAPY SYSTEM AND METHODS OF USE THEREOF  
One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a...
US20180134796 IL13Ra2 Binding Agents and Use Thereof in Cancer Treatment  
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13Rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy...
US20180133184 METHOD FOR TREATING IDIOPATHIC PULMONARY FIBROSIS  
Aspects of the disclosure relate to a method for treating idiopathic pulmonary fibrosis (IPF) in a patient with N-acetylcysteine (NAC) comprising administering NAC to a patient after a sample from...
US20180132756 MEDICAL EVALUATION SYSTEM AND METHOD USING SENSORS IN MOBILE DEVICES  
A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device...
9972089 Contrast medium uptake time computation using magnetic resonance imaging  
A computing device determines a contrast medium uptake time using magnetic resonance imaging data. Image data constructed from data generated by a magnetic resonance imaging (MRI) machine of a...
9968933 Device and method for pressure-driven plug transport and reaction  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
9968668 Staphylococcal coagulase antigens and methods of their use  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20180127676 NANO-ADDITIVES ENABLED ADVANCED LUBRICANTS  
The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to...
US20180122648 Method of Forming Topcoat for Patterning  
Disclosed is a method for the fabrication of polymeric topcoat via initiated chemical vapor deposition (iCVD) or photoinitiated chemical vapor deposition (piCVD) in conjunction with directed...
9957316 Weight loss by inhibition of gastrokine  
Gastrokine-1 (Gkn-1) is a stomach protein that protects the gastrointestinal (GI) tract and has properties to manipulate smooth muscle contraction, prevent NSAID-induced ulceration of the...
US20180112270 C-CBL MUTATIONS AND USES THEREOF  
The present invention relates generally to the fields of molecular biology and growth factor regulation. The invention concerns methods and compositions useful for diagnosing and treating human...
US20180104232 METHODS FOR DETERMINING PROGNOSIS FOR BREAST CANCER PATIENTS  
Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a patient determined to be...
9944992 Methods and compositions related to T-cell activity  
Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of...
9944982 Surface chemistry and deposition techniques  
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface...
US20180102660 MATERIALS FOR USE WITH AQUEOUS REDOX FLOW BATTERIES AND RELATED METHODS AND SYSTEMS  
Described herein are redox flow batteries comprising a first aqueous electrolyte comprising a first type of redox active material and a second aqueous electrolyte comprising a second type of redox...
US20180098947 PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE  
Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing...
9937199 Materials and methods for preventing and treating anastomotic leaks  
Materials and methods for preventing and treating anastomotic leaks are disclosed. Data establishes that pathogenic microbes interfere with establishing epithelial cell barriers in anastomoses...
US20180094283 System for the Production of Methane From CO2  
A method of converting CO2 gas produced during industrial processes comprising contacting methanogenic archaea with the CO2 gas under suitable conditions to produce methane.
US20180092761 BIOMIMETIC AND VARIABLE STIFFNESS ANKLE SYSTEM AND RELATED METHODS  
A cam system for an assistive device and related methods are disclosed. The cam system may comprise a cam profile and a cam follower. The cam profile has a curved outer edge comprising a concave...
US20180087016 CHAMBER FOR IMAGING CELLS AND METHOD OF USE THEREOF  
One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a...
9927706 Atomic layer chemical patterns for block copolymer assembly  
Provided herein are methods of directed self-assembly (DSA) on atomic layer chemical patterns and related compositions. The atomic layer chemical patterns may be formed from two-dimensional...
US20180080030 COMPOSITIONS AND METHODS FOR CORRECTING LIMB GIRDLE MUSCULAR DYSTROPHY TYPE 2C USING EXON SKIPPING  
The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients...
US20180073062 COMPOSITIONS AND METHODS FOR IDENTIFYING ENDOGENOUS DNA-DNA INTERACTIONS  
Provided herein are compositions and methods for identifying endogenous DNA-DNA interactions. In particular, compositions and methods are provided for performing Capture of Associated Targets on...
9916958 Alkali semi-metal films and method and apparatus for fabricating them  
Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as,...
9914847 Resin composition for forming a phase-separated structure, and method of producing structure containing phase-separated structure  
A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (IL) having a cation moiety and an anion moiety, the energy of...
US20180066031 ENZYMATICALLY-CLEAVABLE PEPTIDE AMPHIPHILES  
Provided herein are enzymatically-cleavable peptide amphiphiles and methods of use thereof.
US20180066030 MUTANT HSP70i TO PREVENT AUTOIMMUNE DISEASE  
Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i) having a mutation in the dendritic cell...
9911584 Batch production of microchannel plate photo-multipliers  
In-situ methods for the batch fabrication of flat-panel micro-channel plate (MCP) photomultiplier tube (PMT) detectors (MCP-PMTs), without transporting either the window or the detector assembly...
9907850 Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20180046763 Detection and Visualization of Temporal Events in a Large-Scale Patient Database  
A method for detecting temporal events includes accessing a non-relational database storing patient encounter information for a plurality of encounters and patients. The stored encounter...