Patents and Patent Applications from University of Chicago


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US20120114686 COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) VARIANTS  
Disclosed are methods and compositions for treating or preventing a Staphylococcus bacterial infection using a non-toxigenic Protein A (SpA) variant.
8173803 Supramolecular scaffolds and methods of making the same  
Tribenzo-1,4,7-triazacyclononane and derivatives thereof having a formula (I) are disclosed. Methods of making tribenzo-1,4,7-triazacyclononane and related compounds also are disclosed.
US20120104325 Materials and Methodss for the Preparation of Nanocomposites  
Disclosed herein is an isolable colloidal particle comprising a nanoparticle and an inorganic capping agent bound to the surface of the nanoparticle, a solution of the same, a method for making the...
US20120059044 METHODS OF UTILIZING THE ARRESTIN-2/STAM-1 COMPLEX AS A THERAPEUTIC TARGET  
Methods of utilizing the arrestin-2/sTAM-1 complex as a therapeutic target. The methods include treating cells of a living organism to mediate an interaction between arrestin-2 and STAM-1 adapter...
8129144 Papilloma pseudovirus and preparation  
The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by...
8128242 Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps  
A method of manufacturing a semiconductor device able to reduce the number of manufacturing steps and attain the rationalization of a manufacturing line is disclosed. The semiconductor device is a...
8121245 Imaging system  
A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of...
8116988 Method for indexing nucleic acid sequences for computer based searching  
The present invention relates to a method for indexing nucleic acid sequences to aid computer based searching of nucleic acid sequences by indexing a nucleotide sequence by the presence of unique...
US20120028915 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES  
This invention relates to galactosylceramide compounds.
US20120014947 METHODS AND COMPOSITIONS TO REDUCE LIVER DAMAGE ASSOCIATED WITH CONDITIONS OR THERAPIES THAT AFFECT THE IMMUNE SYSTEM  
One side-effect arising from the use of antibodies against TNF receptor family members as therapeutics can be liver damage which precludes the completion of clinical trial. A novel LT-dependent...
US20110301045 Composition and Methods Related to Modification of 5-Hydroxymethylcytosine (5-hmC)  
The present invention relates generally to the field of molecular biology. More particularly, it concerns methods and compositions for detecting, evaluating, and/or mapping 5-hydroxymethyl-modified...
US20110300533 Yeast Screens for Treatment of Human Disease  
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided...
US20110287504 Method and System for Converting Electricity Into Alternative Energy Resources  
A method of using electricity to produce methane includes maintaining a culture comprising living methanogenic microorganisms at a temperature above 50° C. in a reactor having a first chamber and ...
8062885 Plant centromere compositions  
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve...
US20110274661 Attentuated Herpesvirus Encoding a Mek Pathway Polypeptide  
The disclosure provides materials and methods for the treatment of cells exhibiting a cell proliferative disorder with a herpes simplex virus having a deficiency in the expression of active ICP34.5...
8053627 Methods for treating demyelination disorders  
This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or...
US20110262477 Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
8039209 Yeast screens for treatment of human disease  
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided...
US20110250278 PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE  
Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing...
8034791 Activation of Egr-1 promoter by DNA damaging chemotherapeutics  
The present invention relates to methods of inducing expression of a polynucleotide encoding a therapeutic polypeptide, e.g., TNF-α, in a cell comprising contacting the cell with a construct ...
US20110245168 CONTROL OF GROWTH AND REPAIR OF GASTRO-INTESTINAL TISSUES BY GASTROKINES AND INHIBITORS  
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for...
8017576 Methods and compositions to treat mucositis  
Methods and compositions of AMP-18 derived peptides enablingly demonstrate that AMP-18 derived peptide compositions surprisingly reduce mucositis in mammals. Methods and peptide compositions treat...
US20110207126 CELL-BASED SCREEN FOR AGENTS USEFUL FOR REDUCING NEURONAL DEMYELINATION OR PROMOTING NEURONAL REMYELINATION  
This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or...
US20110206676 COMPOSITIONS AND METHODS RELATED TO STAPHYLOCOCCAL BACTERIUM PROTEINS  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20110200998 Prognosis and Therapy Predictive Markers and Methods of Use  
Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival...
7998739 Methods of activating NKT cells  
Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from...
US20110189774 PLANT CENTROMERE COMPOSITIONS  
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve...
7990524 Stochastic scanning apparatus using multiphoton multifocal source  
A rapid-sampling stochastic scanning multiphoton multifocal microscopy (SS-MMM) fluorescence imaging technique enables multiparticle tracking at rates upwards of 1,000 times greater than...
7989423 6″-amino-6″-deoxygalactosylceramides  
This invention relates to galactosylceramide compounds.
7989202 Plant centromere compositions  
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve...
7989116 Electrolyte utilizing a lewis acid/bronstead acid complex  
A proton conducting polymer is described herein which generally comprises a proton donating polymer and a Lewis acid. The Lewis acids may comprise one or more rare earth triflates. The proton...
US20110177963 Variation in the CHI3L1 Gene Influences Serum YKL-40 Levels, Asthma Risk and Lung Function  
The present invention is based on the discovery that a single nucleotide polymorphism (SNP) present the chitinase 3-like 1 gene (CHI3L1) encoding YKL-40 or a regulatory domain of the CHI3L1 gene,...
US20110177609 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20110177586 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20110177494 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20110176966 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20110174622 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
7983732 Method, system, and computer software product for automated identification of temporal patterns with high initial enhancement in dynamic magnetic resonance breast imaging  
A method, system, and computer software product for analyzing medical images, including obtaining image data representative of a plurality of medical images of the abnormality, each medical image...
US20110165674 NK-1 Receptor Mediated Delivery of Agents to Cells  
Provided herein are conjugates including a targeting vehicle coupled to an agent. The targeting vehicle includes a tachykinin receptor ligand and a reactive moiety. Conjugates including a...
US20110165667 Method and System for Converting Electricity Into Alternative Energy Resources  
A system to convert electric power into methane includes a reactor having a first chamber and a second chamber separated by a proton permeable barrier. The first chamber includes a passage between...
US20110160174 Method Of Treating Disorder Related To High Cholesterol Concentration  
A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits,...
US20110143963 MOLECULAR AFFINITY CLAMP TECHNOLOGY AND USES THEREOF  
The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first...
US20110142734 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20110091375 USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA  
Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed a...
US20110082106 METHODS OF ACTIVATING NKT CELLS  
Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from...
US20110081321 OMENTUM AS A SOURCE OF STROMAL/STEM CELLS AND MEDICAL TREATMENTS USING STROMAL/STEM CELLS  
Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from...
7919310 Constitutive gene expression in conjunction with ionizing radiation  
The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or...
US20110073172 Copper Complex Dye Sensitized Solar Cell  
A dye-sensitized semiconductor includes a semiconductor, and a copper(I) coordination compound comprising 2,9-dialkyl-diphenyl-1,10-phenanthrolinedisulfonate, on the semiconductor. The...
7910714 Monomeric red fluorescent proteins  
Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use.
7910543 Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors  
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for...