Patents and Patent Applications from University of California System


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US20180186867 PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES  
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and...
US20180186630 Graphene Oxide/Metal Nanocrystal Multilaminates the Atomic Limit for Safe, Selective Hydrogen Storage  
Various embodiments of the invention describe an environmentally stable, and exceptionally dense hydrogen storage (6.5 wt % and 0.105 kg H2/L in the total composite, 7.56 wt % in Mg) using...
US20180185814 NANOSTRUCTURED COMPOSITES FOR GAS SEPARATION AND STORAGE  
The disclosure provides nanostructured composites of graphene derivatives and metal nanocrystals for gas storage and gas separation.
US20180185642 ACCESSING SPINAL NETWORK TO ENABLE RESPIRATORY FUNCTION  
In various embodiments, methods are provided for improving, and/or regulating, and/or restoring respiration in a subject with a respiratory deficiency. In certain embodiments the methods involve...
US20180185549 Nanostructure Surface Coated Medical Implants and Methods of Using the Same  
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a...
US20180185415 RETROVIRAL VECTORS CONTAINING A REVERSE ORIENTATION HUMAN UBIQUITIN C PROMOTER  
In certain embodiments a recombinant retroviral vector is provided where the vector comprises a human ubiquitin C (UBC) promoter operably linked to a transgene where the promoter and the transgene...
US20180185309 METHODS AND COMPOSITIONS FOR TREATING NEPHROPATHY  
Provided are compositions and methods for improving podocyte and kidney function and glucose homeostasis in diabetic and pre-diabetic states.
US20180185303 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER  
A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer...
10012674 Nanoantenna scanning probe tip, and fabrication methods  
The invention provides a nanoantenna scanning probe tip for microscropy or spectroscopy. The nanoantenna scanning probe tip includes a sharp probe tip covered with a contiguous film of...
10010933 Magnetically controlled casting process for multistructural materials  
The disclosure provides a method to produce solid materials displaying structural ordering which can be controlled through a wide range of sizes and shapes. The process involves casting a medium,...
10010713 Nerve stimulation device for treating or reducing paralysis  
Disclosed herein is a method of treating a disease, comprising: (a) implanting an array of electrodes on one or more targeted nerves and/or targeted muscles; and (b) treating the disease by...
10010666 Balloon catheter method for reducing restenosis via irreversible electroporation  
Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The...
10010629 Compositions and methods for in vivo imaging  
The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
10010595 Live recombinant booster vaccine against tuberculosis  
Embodiments of the invention comprise an improved vaccine for generating an immune response and preventing or treating mycobacterial diseases such as tuberculosis in humans and animals....
10010525 Methods of inducing anesthesia  
The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The...
US20180182565 METHODS, DEVICES AND SYSTEMS FOR ACTIVATED CARBON SUPERCAPACITORS WITH MACROPOROUS ELECTRODES  
Energy storage devices comprising carbon-based electrodes and/or redox electrolytes are disclosed herein. In some embodiments, the carbon-based electrodes comprise laser-scribed activated carbon...
US20180180689 SPECIALIZED DIAMOND MATERIALS FOR NMR APPLICATIONS  
Polarizable diamond materials and methods for obtaining nuclear magnetic resonance spectra of samples external to the diamond materials are described. The diamond materials can include 12C, 13C,...
US20180180612 MONOCYTE INTEGRIN BASED MICROFLUIDIC ASSAY FOR EVALUATING CORONARY DISEASES  
A diagnostic system for assessing cardiovascular health is provided that incorporates a microfluidic platform and sensors that capture inflammatory monocytes. The portable microfluidic platform...
US20180180595 CELL LINES MUTANT FOR PATCHED 1 AND PATCHED 2 AND METHODS OF USE THEREOF  
The present disclosure provides a genetically modified cell, wherein the cell is genetically modified such that it does not produce functional Ptch1 and Ptch2 protein. The present disclosure...
US20180180573 GAS DETECTION SYSTEMS AND METHODS USING GRAPHENE FIELD EFFECT TRANSISTORS  
A gas detection system for selectively detecting one or more gases from a mixture of gases includes a gas sensor that includes at least one graphene field effect transistor (GFET). The GFET...
US20180180325 HIGH TEMPERATURE SYNTHESIS FOR POWER PRODUCTION AND STORAGE  
Thermochemical energy storage (TCES) for concentrating solar power (CSP) systems provides higher energy density than sensible energy storage systems. An ammonia-based TCES system dissociates...
US20180179579 METHODS OF PRODUCING NUCLEIC ACID LIBRARIES AND COMPOSITIONS AND KITS FOR PRACTICING SAME  
Aspects of the present disclosure include methods of producing nucleic acid libraries. In certain aspects, the methods include producing tagged primer extension products, and contacting aliquots...
US20180179576 HOMOGENEOUS ENTROPY-DRIVEN BIOMOLECULAR ASSAY (HEBA)  
A method for detecting an analyte in a sample includes the steps of binding a first catalytic precursor to the analyte at a first epitope and binding a second catalytic precursor to the analyte at...
US20180179512 Novel self-photosensitized nonphotosynthetic microorganism  
The present invention provides for a genetically modified microorganism capable of photosynthesizing an organic compound from carbon dioxide, wherein the microorganism comprises a semiconductor...
US20180177786 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER  
A method of treating prostate cancer in a subject with biochemically recurrent prostate cancer is provided. The method includes administering to a subject in need thereof an effective amount of a...
US20180177765 Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone  
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.
US20180177729 G PROTEIN-COUPLED RECEPTORS INCORPORATED INTO REHYDRATED POLYMER VESICLES RETAIN FUNCTIONALITY  
A G Protein Coupled Receptor (GPCR) is incorporated in polymeric giant unilamellar protein vesicles (pGUPs). By utilizing an agarose rehydration technique, the GPCR is inserted in the biased,...
US20180177724 SITE-TARGETED NANO-LIPOSOMAL NITROGLYCERIN THERAPEUTICS  
The disclosure provides for nanoliposomal formulations comprising nitroglycerin, methods of making the formulations, and methods of use thereof.
US20180177562 STEREOTACTIC DEVICE FOR IMPLANTATION OF PERMANENT IMPLANTS INTO A RODENT BRAIN  
Stereotactic systems and implantation methods that can be designed for use with a specific species and further customized for use with an individual within the species are provided. The...
US20180177558 PRECISION INJECTOR/EXTRACTOR FOR ROBOT-ASSISTED MINIMALLY-INVASIVE SURGERY  
According to some embodiments of the invention, a surgical robot includes a robot arm having an end effector, the end effector comprising a needle assembly. The surgical robot further includes a...
US20180177543 METHOD AND DEVICE FOR ELECTROCHEMICAL THERAPY OF SKIN AND RELATED SOFT TISSUES  
A method of altering skin tissue includes creating an electrochemical reaction in the tissue, wherein the electrochemical reaction occurs while avoiding electro-thermal damage to the tissue.
US20180177428 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS  
An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and...
10009038 Wideband Nyquist VCO-based analog-to-digital converter  
An analog-to-digital converter may convert an analog signal into digital codes representative of the changing level of the analog signal. An analog high pass filter may receive and continuously...
10008683 Flexible organic transistors with controlled nanomorphology  
An organic device, including semiconducting polymers processed from a solution cast on one or more dielectric layers on a substrate; and electrical contacts to the semiconducting polymers, wherein...
10006911 Methods and devices for integrating analyte extraction, concentration and detection  
Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a...
10006085 Nanostructured arrays on flexible polymer films  
The present invention relates to nanocones and nanomaterials. In one embodiment, the present invention provides a method of fabricating an array of nanostructures on a flexible film, comprising...
10006033 Recombinant microorganisms having a methanol elongation cycle (MEC)  
Provided are microorganisms that catalyze the synthesis of chemicals and biochemicals from a methanol, methane and/or formaldehyde. Also provided are methods of generating such organisms and...
10005838 Milk fat globule epidermal growth factor 8 regulates fatty acid uptake  
Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. The method comprises administering an antagonist of integrin αvβ3 or αvβ5 to...
10005745 Amyloid targeting agents and methods of using the same  
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced...
10005735 Inhibitors of RPN11  
Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and...
10005248 Method and kit for forming plastic lenses from molds formed on surface with varied wettability  
This disclosure provides a monolithic mold including a plurality of lens forming features that can be used to simultaneously form a plurality of lenses with different sizes and shapes. The mold...
10004775 Inhibition of hypoxia-inducible factor activity with carica papaya extracts  
An extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed is used as an inhibitor of HIF to effectively block...
10004751 Compositions and methods for treating Dengue virus infection  
The present disclosure provides methods of treating a flavivirus infection, and compositions for use in the methods.
US20180175456 NOVEL HIGH VOLTAGE 10, 11, AND 12-VERTEX CARBORANE AND BORANE ELECTROLYTES, THEIR USE IN RECHARGABLE BATTERIES, AND PROCESSES FOR THEIR PREPARATION  
The present disclosure provides electrolytes for an electrochemical device. In some embodiments, these electrolytes are Mg salts comprising 10- vertex or 12-vertex carborane anions. The present...
US20180175297 Screen Printing Systems and Techniques for Creating Thin-Film Transistors Using Separated Carbon Nanotubes  
A method of fabricating a thin film transistor, the method includes applying a first ink containing metallic particles to a first screen mask, and using the first screen mask to deposit the first...
US20180172683 METHODS FOR ANALYZING THE INTERACTION BETWEEN A TARGET PROTEIN AND A LIGAND  
Provided is a method for simultaneously determining both [L]0 and Kd values of a ligand for a target protein. In one embodiment, the present technology involves performing quantitative equilibrium...
US20180171385 ALKB -FACILITATED RNA METHYLATION SEQUENCING (ARM-SEQ)  
In various embodiments, the invention teaches methods for detecting ribonucleic acid (RNA) molecules that contain certain chemical modifications using sequencing technologies. These modified RNAs...
US20180171363 PRODUCTION OF BETA-PHELLANDRENE USING GENETICALLY ENGINEERED PHOTOSYNTHETIC MICROORGANISMS  
The present invention provides methods and compositions for producing β-phellandrene hydrocarbons from a photosynthetic microorganism such as cyanobacteria.
US20180171342 FUSION CONSTRUCTS AS PROTEIN OVER-EXPRESSION VECTORS  
This invention provides compositions and methods for providing high product yield of transgenes expressed in cyanobacteria and microalgae.
US20180171331 METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS IN AN ARRAY  
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask that protects regions of interest...