Patents and Patent Applications from University of California System


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US20180116541 System and Method for Monitoring and Treating Arrhythmia and Cardiac Function via the Intrinsic Cardiac Nervous System  
The present invention includes systems and methods for measuring, monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system. The systems and methods compare...
US20180116525 FLEXIBLE, NON-INVASIVE REAL-TIME HEMATOMA MONITORING SYSTEM USING NEAR-INFRARED SPECTROSCOPY  
NIRS systems including fully-printed LEDs and PDs operating in the NIR spectrum are provided that provide conformal adherence to a patient's head and efficient measurement of near-infrared...
US20180116141 HAPLOID INDUCTION  
Mutations in CENH3 have been identified that are useful for generating haploid progeny.
RE46817 Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores  
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
9960447 Polymer network single ion conductors  
The disclosure provides for polymer networks that can effectively conduct single ion electrolytes.
9958185 Solar thermal concentrator and method of forming same  
A concentrator tube comprises a reflector portion having two walls; and an aperture closing an opening to the reflector portion. The aperture and the reflector portion extend longitudinally. The...
9957509 Synthetic gene clusters  
Methods for making synthetic gene clusters are described.
9957403 Aqueous dispersion of hydrophobically modified pigment particles  
The present invention relates to a composition comprising a) a stable aqueous dispersion of inorganic pigment particles hydrophobically modified with covalently bonded polysiloxane or silyl...
9956743 Superhydrophobic and superoleophobic nanosurfaces  
Devices, systems and techniques are described for producing and implementing articles and materials having nano-scale and microscale structures that exhibit superhydrophobic, superoleophobic or...
9956551 Nano-to-nano Fe/ppm Pd catalysis of cross-coupling reactions in water  
In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle...
9955886 Focused recording and stimulation electrode array  
Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode...
9955879 System for analysis of complex rhythm disorders  
A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals...
US20180115070 BULK ACOUSTIC WAVE MEDIATED MULTIFERROIC ANTENNAS  
An antenna apparatus utilizing bulk acoustic wave (BAW) resonances to transfer dynamic strain across multiple layers, which include piezoelectric layers coupled to magnetostrictive material...
US20180114637 MAGNETICALLY TUNABLE PHOTONIC CRYSTALS BASED ON ANISOTROPIC NANOSTRUCTURES  
A method is disclosed of forming magnetically tunable photonic crystals comprising: synthesizing one or more precursory nanoparticles with anisotropic shapes; coating the one or more anisotropic...
US20180114096 MACHINE LEARNING TO PROCESS MONTE CARLO RENDERED IMAGES  
A method of rendering an image includes Monte Carlo rendering a scene to produce a noisy image. The noisy image is processed to render an output image. The processing applies a machine learning...
US20180113123 SHRINK ELECTRODE  
A sensor including a flexible substrate, a conductor disposed on the flexible substrate, and a hydrophilic surface coating disposed on the conductor. The flexible substrate and the conductor form...
US20180113112 Methods of Diagnosing Post-Operative Complications Using Serum Nitric Oxide Levels  
Disclosed herein are methods of using serum nitric oxide levels to diagnose subjects as having or likely to develop a post-operative complication.
US20180112200 COMPOSITIONS AND METHODS FOR GENERATING ANTIGENS, ANTIBODIES, AND IMMUNOTHERAPEUTIC COMPOSITIONS AND METHODS  
In some aspects, the invention relates to compositions and methods of generating antigens, wherein the antigen is a biomolecule that is modified by a reactive oxygen species or a reactive nitrogen...
US20180112170 SIEVE SYSTEM AND METHODS FOR CELL MEDIA EXCHANGE  
Methods and systems for cell media exchange wherein media maybe aspirated without also aspirating cells and wherein removal and re-plating of cells is not necessarily required. For example, the...
US20180112034 SUBSTITUTED POLYESTERS BY THIOL-ENE MODIFICATION: RAPID DIVERSIFICATION FOR THERAPEUTIC PROTEIN STABILIZATION  
Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6,...
US20180112003 CAR T-CELL THERAPY DIRECTED TO LHR FOR THE TREATMENT OF SOLID TUMORS  
Provided herein are novel anti-LHR chimeric antigen receptor (CAR), cells or compositions comprising the same, vector or plasmid encoding anti-LHR CAR, and methods for producing the same, or using...
US20180112002 MODULATORS OF ROR1-ROR2 BINDING  
Provided herein are, inter alia, methods of identifying agents that are capable inhibiting the binding (e.g., coupling) between a ROR1 protein and a ROR2 protein. By interfering with ROR1-ROR2...
US20180111955 THIOSACCHARIDE MUCOLYTIC AGENTS  
There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective...
US20180111263 METHOD AND APPARATUS FOR HUMAN ARM SUPPORTING EXOSKELETON  
An arm supporting exoskeleton comprises a shoulder base coupled to an arm link mechanism. The arm link mechanism comprises a proximal link and a distal link configured to rotate relative to each...
US20180111262 METHOD AND APPARATUS FOR HUMAN ARM SUPPORTING EXOSKELETON  
An arm supporting exoskeleton comprises a shoulder base coupled to an arm link mechanism. The arm link mechanism comprises a proximal link and a distal link configured to rotate relative to each...
US20180110866 POLYMERIC ANTIBIOTICS  
The disclosure provides, inter alia, polymeric antibiotic compounds such as modified chitosans and methods of use thereof.
US20180110784 SYNTHETIC TLR4 AND TLR7 LIGANDS TO PREVENT, INHIBIT OR TREAT LIVER DISEASE  
Methods of using TLR7 conjugates or TLR4 ligands, or a combination thereof, to treat fibrosis are provided.
US20180110757 METHODS OF TREATING PRURITIS AND PAIN  
The present disclosure provides compositions and methods for treating pruritis and for treating certain types of pain.
US20180110727 CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS  
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal,...
US20180110632 MECHANISM FOR EFFICIENT DONNING AND DOFFING OF AN EXOSKELETON  
A manual apparatus of the present disclosure enables quick connection and disconnection of an exoskeleton leg from a remaining body of an exoskeleton. The apparatus comprises a cavity defined by a...
US20180110492 ENCAPSULATED GAS OR PARTIAL VACUUM CONTRAST MATERIAL  
The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium...
9953246 Feature-preserving noise removal  
A noise removal method includes receiving in a de-noising system multiple noisy copies of a target image; providing the noisy copies as input data to the de-noising system in a training phase, and...
9952453 Broadband metacoaxial optical nanoantennas based on plasmonic modes  
Techniques, systems, and devices are disclosed for implementing nanostructures in the optical domain that highly localize the incident electromagnetic field to with a large spectral range from the...
9952216 Brain-specific enhancers for cell-based therapy  
Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to...
9951912 Tunable white light based on polarization sensitive light-emitting diodes  
A lighting apparatus for emitting polarized white light, which includes at least a first light source for emitting primary light comprised of one or more first wavelengths and having a first...
9951354 Production of β-phellandrene using genetically engineered cyanobacteria  
The present invention provides methods and compositions for producing β-phellandrene hydrocarbons from cyanobacteria.
9951345 Host cells and methods for producing diacid compounds  
The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more...
9951118 Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors  
The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling HIV replication and is an important part of the ultimate failure to eradicate the virus. Disclosed...
9951107 Vault complexes  
The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to...
9951097 Antibacterial compounds targeting isoprenoid biosynthesis  
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by...
9950715 Air-coupled ultrasonic inspection of rails  
In some example implementations, there is provided a method. The method may include generating, by an air-coupled transducer, a first ultrasonic guided wave to cause the generated ultrasonic...
9950341 Systems and methods for fabricating spiral coils with atomized bioactive coatings  
Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via...
9950001 Polynucleotides having bioreversible groups  
The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge-neutralizing...
9949927 Bis-polymer lipid-peptide conjugates and nanoparticles thereof  
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can...
US20180109339 SYSTEM AND METHOD OF OCCUPANCY ESTIMATION UTILIZING TRANSMITTED SIGNALS  
A method estimating number of occupants in a region includes receiving at one or more receiving unit a signal or signals transmitted from one or more transmitting units, wherein the transmitting...
US20180108964 INTEGRATED ANTENNAS AND PHASED ARRAYS WITH MODE-FREE ELECTROMAGNETIC BANDGAP MATERIALS  
A multifunctional electromagnetic structure is presently disclosed. Said structure is a true electromagnetic bandgap (“EBG”) material, with both surface and leaky waves suppressed from the whole...
US20180108510 STABLE SUPPORT FILMS FOR ELECTRON MICROSCOPY  
This disclosure provides systems, methods, and apparatus related to arrangements including electron microscopy grids. In one aspect an arrangement includes an electron microscopy grid. The...
US20180106729 IMAGING PLATFORM BASED ON NONLINEAR OPTICAL MICROSCOPY FOR RAPID SCANNING LARGE AREAS OF TISSUE  
A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm2 (without stitching adjacent FOVs) at speeds of 10 frames/second...
US20180106724 OPTICAL SENSING WITH CRITICALLY COUPLED PLANAR WAVEGUIDE WITH OPTIONAL INTEGRATION OF LAYERED TWO-DIMENSIONAL MATERIALS  
An optical sensing system includes a planar optical waveguide having a first surface for detection and a second surface for coupling light. The optical sensing system includes a functional layer...
US20180105802 Viral Targeting with Knottins  
The use of targeting knottin polypeptides provides a means of selectively infecting target cells presenting species bound by the knottins. The targeted viruses may be used as cytotoxic agents, for...