Patents and Patent Applications from University of California System


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US20180271911 INDUCED PLURIPOTENT STEM CELL DERIVED GLIAL ENRICHED PROGENITOR CELLS FOR THE TREATMENT OF WHITE MATTER STROKE  
In various embodiments methods and compositions for improving a recovery of a subject after a cerebral ischemic injury, such as white matter stroke are provided. In certain embodiments, the...
US20180271770 Compositions And Methods Of Using The Same For Decontamination Of Skin  
The present disclosure provides compositions comprising decontaminating compounds, and pharmaceutically acceptable salts thereof and methods of treating or preventing a contamination in a mammal,...
10084184 Conformal coating of nano-porous material with group IV semiconductor using nanoparticle ink  
A nanostructured composite material includes a substrate, a porous layer including a highly structured material, and a coating including nanoparticles. A method for forming the nanostructured...
10083394 Neural processing engine and architecture using the same  
A neural processing engine may perform processing within a neural processing system and/or artificial neural network. The neural processing engine may be configured to effectively and efficiently...
10083305 Method and system providing mutli-level security to gate level information flow  
A preferred method for providing multi-level security to a gate level information flow receives or specifies a security lattice having more than two security levels. The security lattice defines...
10082497 Device and method for force phenotyping of cells for high-throughput screening and analysis  
A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An...
10081835 Nucleotide sequencing using an array of independently addressable nanopores  
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods...
10081017 Method and system for ultra-high dynamic range nucleic acid quantification  
A method of quantifying nucleic acids in a sample includes generating a plurality of droplets in oil within a microfluidic device, wherein at least some of the droplets comprise a nucleic acid,...
10081005 Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers  
An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the...
10080749 Multi-drug therapies for tuberculosis treatment  
The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
10080745 Piericidin bacterial inhibitors  
Described herein are assays for identifying piericidins and piericidin compositions.
10080642 Stent with expandable foam  
A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.
US20180269052 DETECTION OF ANALYTES USING POROUS MASS SPECTROMETRY SURFACE  
The disclosure herein includes compositions and methods for ionizing targets and methods for making the compositions. In some embodiments, the compositions can include a porous substrate that has...
US20180268912 Flash Memory Array With Individual Memory Cell Read, Program and Erase  
A memory device that provides individual memory cell read, write and erase. In an array of memory cells arranged in rows and columns, each column of memory cells includes a column bit line, a...
US20180267503 SYSTEM AND METHOD FOR EXTRACTING PRINCIPAL TIME SERIES DATA  
A method for extracting a set of principal time series data of dynamic latent variables. The method includes detecting, by a plurality of sensors, dynamic samples of data each corresponding to one...
US20180267027 FLUORESCENT BIOSENSOR FOR METHYLTRANSFERASE ASSAY  
A single stranded nucleic acid biosensor for S-adenosylhomocysteine (SAH) is provided. The single stranded nucleic acid may include a SAH-binding riboswitch domain comprising a P2′ stem and a...
US20180266452 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME  
A method of forming three-dimensional shaped microparticles in a microfluidic device includes flowing a mixture of a monomer and photoinitiator in a microfluidic channel having a plurality of...
US20180266104 CONTROL SYSTEM AND METHOD FOR MITIGATING THE EFFECTS OF NATURAL HAZARDS  
An actuator includes a piston, a relief valve in fluid communication with the piston, and an input shaft for moving fluid in a chamber near the piston. The relief valve determines an amount of...
US20180265886 HYPERSENSITIVE ABA RECEPTORS  
Hypersensitive PYR/PYL polypeptides, compositions, and methods are provided.
US20180265576 ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS  
The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the...
US20180265497 PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS  
Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I′ structure: or stereoisomers,...
US20180265464 Synthetic Sphingolipid-Like Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment  
Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the...
US20180264466 POSITION-DEFINED CELL CULTURE AND CHARACTERIZATION PLATFORM  
Methods, systems, and devices are disclosed for culturing and characterizing individual cellular entities including cells organoids, or tissue. In one aspect, a device includes a first substrate...
US20180264053 MICROBIAL CONSORTIUM AND USES THEREOF  
Provided herein are, inter alia, microbial compositions and methods of using the same. The microbial compositions provided include, inter alia, therapeutically effective amounts of Lactobacillus...
US20180264004 NOVEL CHEMOIMMUNOTHERAPY FOR EPITHELIAL CANCER  
The invention provides a method for treating cancer in a subject in need thereof, wherein said subject comprises cancer tissue that ‘contains epithelial cancer cells and immunosuppressive 8 cells,...
US20180263539 WEARABLE SENSOR ARRAYS FOR IN-SITU BODY FLUID ANALYSIS  
A wearable sensing platform includes sensors and circuits to sense aspects of a user's state by analyzing bodily fluids, such as sweat and/or urine, and a user's temperature. A sensor array senses...
US20180263535 SYSTEMS AND METHODS FOR FACILITATING REHABILITATION THERAPY  
A rehabilitation system includes a portable patient workstation configured to facilitate in-home rehabilitation therapy. In some embodiments, the workstation includes a computing device and one or...
10079387 Electrical conductive polymer binder for Si alloy materials  
A Poly(1-pyrenemethyl methacrylate-co-dopamine methacrylamide) PPyDMA polymer binder has been designed and fabricated, and has demonstrated an excellent performance for silicon (Si), graphite and...
10078593 Multiple-core computer processor for reverse time migration  
A multi-core computer processor including a plurality of processor cores interconnected in a Network-on-Chip (NoC) architecture, a plurality of caches, each of the plurality of caches being...
10078023 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Plasmonic nanoparticle-based colorimetric stress memory sensor
 
The development of a stress-responsive colorimetric film that can memorize the stress it has experienced is disclosed. The system can use the plasmonic shift associated with the disassembly of...
10077445 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
 
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a...
10077300 Activatable binding polypeptides and methods of identification and use thereof  
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which...
10077260 Read-through compound prodrugs suppressing premature nonsense mutations  
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments, the compounds are of Formula Ia or a...
10077236 Azacyclic constrained analogs of FTY720  
Small molecules comprised of azacyclic constrained analogs of FTY720 are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for...
10076533 Acyclic nucleoside phosphonate diesters  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
10076532 Acyclic nucleoside phosphonate diesters  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
10076242 Systems and methods for automated classification of abnormalities in optical coherence tomography images of the eye  
Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment...
US20180261115 Enhancing Cognition in the Presence of Distraction and/or Interruption  
The present disclosure relates to methods and tools for enhancing cognition and improving well being in an individual. The methods involve presenting to an individual a task to be performed,...
US20180260603 ADJUSTABLE FINGERPRINT CAPTURING DEVICE  
An adjustable fingerprint capturing device is configured to stabilize a finger of a subject. The adjustable fingerprint capturing device comprises an imaging device(s) configured to capture an...
US20180259521 METHODS AND DEVICES FOR ANALYTE COLLECTION, EXTRACTION, CONCENTRATION, AND DETECTION FOR CLINICAL APPLICATIONS  
In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the...
US20180259480 FUNCTIONALIZED NANOPIPETTE BIOSENSOR  
Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions,...
US20180259127 GAS FUELING SYSTEMS AND METHODS WITH MINIMUM AND/OR NO COOLING  
Gaseous fueling systems and methods are provided for dispensing fuel to a vehicle or container. The distribution systems speed up the filling process and may eliminate the use of expensive cooling...
US20180258474 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE  
Disclosed are methods for polynucleotide sequencing that detect the location of selected nucleobases with greater precision. The methods can be used to determine the location and nature of...
US20180258111 Acene-based transmitter molecules for photon upconversion  
Provided herein are transmitter ligands that improve photon upconversion of near infrared light (NIR) to visible light. The presently provided ligands are complexed to semiconductor nanocrystals...
US20180256912 METHOD FOR MONITORING TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The present invention provides methods for monitoring neuropsychiatric treatment of depression and other disorders. The methods monitor the progress of neuropsychiatric treatment by examining...
US20180256726 EDIBLE OILS TO ENHANCE DELIVERY OF ORALLY ADMINISTERED STEROIDS  
The present invention relates to the formulation of steroids, including neurosteroids (e.g., allopregnanolone (ALP)) in edible oils to enhance their absorption when administered, e.g., orally or...
US20180256690 PROTECTION AND SEALING OF THE OCULAR SURFACE BARRIER BY CLUSTERIN  
A method of treating dry eye disease is provided. The method includes administering to a patient in need thereof an effective amount of a pharmaceutical composition that includes an isolated...
US20180256688 METHODS AND COMPOSITIONS FOR IMPROVED COGNITION  
Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.
US20180256509 Nanoparticle Compositions and Methods Thereof to Restore Vascular Integrity  
The present invention relates to methods for treating systemic inflammation. In certain embodiments, the method comprises administering a therapeutically effective amount of curcumin-selenium...
10075145 Phase noise measurement and filtering circuit  
Methods and apparatuses for measuring a phase noise level in an input signal are disclosed. An input signal can be delayed to generate a delayed version of the input signal. Next, a phase...