Patents and Patent Applications from University of California System


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9886493 Systems and methods for sensory and cognitive profiling  
Methods, devices, and systems are disclosed for producing cognitive and/or sensory profiles. In one aspect, a method to provide a cognitive or sensory assessment of a subject includes selecting a...
9885071 Polymer enhancement of enzymatic activity  
Provided herein are methods for enhancing enzymatic activity using certain polymers that may be optionally attached to an enzyme. The polymers may be thermally-responsive polymers, including poly...
9885059 Ultrahigh throughput microinjection device  
Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This...
9885014 Re-conditioned serum-free culture medium composition obtained by culturing mammalian cells in Fibromodulin  
The present invention provides pluripotent stem cell like (PSCL) cells or clones, a culture medium therefore, and a supernatant thereof, and methods of making and using the same.
9884070 Selective high-affinity polydentate ligands and methods of making such  
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically...
9883812 Enhanced multi-core beamformer algorithm for sensor array signal processing by combining data from magnetoencephalography  
Techniques and systems are disclosed for implementing multi-core beamforming algorithms. In one aspect, a method of implementing a beamformer technique includes using a spatial filter that...
US20180034556 SYSTEMS AND TECHNIQUES FOR COMMUNICATION USING COMBINED ORBITAL ANGULAR MOMENTUM AND MULTIPLE-INPUT-MULTIPLE-OUTPUT PROCESSING  
A system includes a transmitter with multiple transmit devices each having an OAM multiplexer that converts multiple input signals into an OAM beam. Each transmit device outputs a coaxial group of...
US20180034059 COATED SULFUR PARTICLE ELECTRODE AND METHOD  
A coated sulfur particle and methods are shown. In one example, the coated sulfur particles are used as an electrode in a battery, such as a lithium ion battery.
US20180034041 Conductive Polymer and Si Nanoparticles Composite Secondary Particles and Structured Current Collectors for High Loading Lithium Ion Negative Electrode Application  
Embodiments of the present invention disclose a composition of matter comprising a silicon (Si) nanoparticle coated with a conductive polymer. Another embodiment discloses a method for preparing a...
US20180033983 EFFICIENT AND STABLE PEROVSKITE SOLAR CELLS WITH ALL SOLUTION PROCESSED METAL OXIDE TRANSPORTING LAYERS  
An opto-electronic device includes a first electrode, a first buffer layer formed on the first electrode, and a perovskite semiconductor active layer formed on the first buffer layer. The...
US20180033977 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES  
A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X1 and X2 are selected from alkyl, cycloalkyl, alkoxy,...
US20180033971 FORMATION AND STRUCTURE OF LYOTROPIC LIQUID CRYSTALLINE MESOPHASES IN DONOR-ACCEPTOR SEMICONDUCTING POLYMERS  
Design of side chains yielding highly amphiphilic conjugated polymers is proven to be an effective and general method to access lyotropic liquid crystalline mesophases, allowing greater control...
US20180031949 HETEROGENEOUS WAVEGUIDES AND METHODS OF MANUFACTURE  
A heterogeneous waveguide is configured to achieve a nonlinear optical interaction, the waveguide including at least two materials in cross-section. The first material may or may not be poled or...
US20180031851 OPTICAL PULSE COMBINER COMPRISING DIFFRACTIVE OPTICAL ELEMENTS  
This disclosure provides systems, methods, and apparatus related to optical systems. In one aspect, an optical system includes a plurality of optical sources, a first diffractive optical element,...
US20180031585 METHODS AND COMPOSITIONS FOR IDENTIFYING NON-ALCOHOLIC FATTY LIVER DISEASE  
The disclosure provides methods for differentiating between non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. The method includes measuring eicosanoids and fatty acid levels in...
US20180030531 METHODS FOR DETERMINING GENE FUNCTIONS  
Disclosed herein are methods, systems and compositions for determining substrate specificity of an enzyme. The disclosed methods, systems and compositions can be used for identifying enzymes...
US20180030525 NANOPORE SEQUENCING OF POLYNUCLEOTIDES WITH MULTIPLE PASSES  
Disclosed are methods and materials for rereading individual single-stranded DNA or RNA molecules with a nanopore device. A single strand polymer can be passed through a nanopore in a nanopore...
US20180030497 MULTIPLE-USE RENEWABLE ELECTROCHEMICAL SENSORS BASED ON DIRECT DRAWING OF ENZYMATIC INKS  
Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or more biocompatible binders, one or more...
US20180030481 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS  
The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased...
US20180030435 MULTIPLEX CHARACTERIZATION OF MICROBIAL TRAITS USING DUAL BARCODED NUCLEIC ACID FRAGMENT EXPRESSION LIBRARY  
Disclosed herein are barcoded expression libraries comprising a plurality of expression vectors, wherein each expression vector comprises a nucleic acid fragment flanked by a first barcode and a...
US20180030042 Methods, Compounds, and Compositions for the Treatment of Angiotensin-Related Diseases  
Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases,...
US20180029980 PREPARATION OF COMPOUNDS FROM LEVULINIC ACID  
The present invention provides a method of making carboxylic acids from levulinic acid, such as succinic acid and 3-hydroxypropanoic acid, by reacting levulinic acid with an oxidant such as...
US20180029044 CONTINUOUS WHOLE-CHIP 3-DIMENSIONAL DEP CELL SORTER AND RELATED FABRICATION METHOD  
A 3-dimensional PDMS cell sorter having multiple passages in a PDMS layer that follow the same path in a DEP separation region and that are in fluid communication with each other within that...
US20180028790 SHEATH FOR MAINTAINING POSITION IN A PERICARDIAL SPACE  
The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the...
US20180028617 METHODS OF TREATING MILD BRAIN INJURY AND POST-TRAUMATIC STRESS DISORDER  
The present disclosure provides methods for treating Post-Traumatic Stress Disorder (PTSD) and other neurological disorders in a subject, comprising administering to the subject an effective...
US20180028598 Compostions for Treating Dry Eye Disease  
The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or an undesired condition that is...
US20180028499 5HT AGONISTS FOR TREATING DISORDERS  
Provided, inter alia, are methods for treating an epilepsy disorder using a 5HT receptor agonist, or a pharmaceutically acceptable salt thereof.
US20180028408 Systems And Methods For Controlling And Monitoring Medication Dispensation  
In one embodiment, a medication dispensing device of a system for controlling and monitoring medicine dispensation includes means for securely containing a medication to be dispensed to a specific...
9882108 Nanostructured layers of thermoelectric materials  
This disclosure provides systems, methods, and apparatus related to thermoelectric materials. In one aspect, a method includes providing a plurality of nanostructures. The plurality of...
9881999 Methods of fabricating nanostructures and nanowires and devices fabricated therefrom  
One-dimensional nanostructures having uniform diameters of less than approximately 200 nm. These inventive nanostructures, which we refer to as “nanowires”, include single-crystalline...
9881699 Cellular structures with interconnected microchannels  
A method for fabricating a cellular tritium breeder component includes obtaining a reticulated carbon foam skeleton comprising a network of interconnected ligaments. The foam skeleton is then...
9880246 Linear transform for diffusion MRI  
Samples of a Fourier transform of a signal may be received that are distributed in a generally spherically-shaped pattern on a surface of at least one sphere. The samples may be assembled to form...
9880238 MRI receiver coil providing an enhanced signal-to-noise ratio  
A Magnetic Resonance Imaging (MRI) receiver includes a receiver coil on a substrate. The receiver coil includes one or more capacitors. The construction of the capacitors allows for the use of...
9880173 Pyrite shrink-film laminate as a hydroxyl radical generator  
Disclosed are hydroxyl radial generating devices, comprising: a substrate layer; and a pyrite layer configured to produce hydroxyl radicals. Another aspect relates to a method for producing a...
9879322 Compositions and methods for determining genetic polymorphisms in the TMEM216 gene  
In alternative embodiments, the invention provides nucleic acid sequences that are genetic polymorphic variations of the human TMEM216 gene, and TMEM216 polypeptide encoded by these variant...
9879310 Nano/microscale vehicles for capture and isolation of target biomolecules and living organisms  
Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to...
9879224 Label-free identification of stem cell-differentiated cells  
Methods are disclosed for isolation of a stem-cell derived differentiated cell, which method entails illuminating an incident light onto a plurality of stem-cell derived cells that comprise at...
9879068 Antibodies targeting HIV escape mutants  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for...
9878137 Bioactive agent delivery devices and methods of making and using the same  
A method of preparing a substantially planar microdevice comprising a plurality of reservoirs is provided. In general, the method comprises forming a plurality of microdevices comprising a...
9878033 Immunogenic peptides for treatment of herpes simplex virus infection and conditions  
Certain embodiments of the present invention provide immunogenic compositions that comprise one or more peptides having an amino acid sequence selected from the group consisting of NLLTTPKFT and...
9878006 Treatment of obesity and obesity related disorders by pharmalogical targeting of Kv1.3 potassium channels  
Activation of brown adipose tissue, treatment of obesity and/or treatment of obesity-related disorders in human or non-human animal subjects by administering to the subject a potassium channel...
9877770 Potential driven electrochemical modification of tissue  
The present invention relates to the use of electrochemistry to control and generate specific user defined chemical reactions in regions that may be defined by electrode placement and geometry. In...
9877479 Pamoic acid blocks ethelyne signaling  
The disclosure provides methods and compositions for modulating ethylene and auxin signaling and ethylene production in plants.
US20180026422 BULK DIRECT GAP MOS2 BY PLASMA INDUCED LAYER DECOUPLING  
Bulk direct transition metal dichalcogenide (TMDC) may have an increased interlayer separation of at least 0.5, 1, or 3 angstroms more than its bulk value. The TMDC may be a bulk direct band gap...
US20180026185 FAR-INFRARED DETECTION USING WEYL SEMIMETALS  
The generation of photocurrent in an ideal two-dimensional Dirac spectrum is symmetry forbidden. In sharp contrast, a three-dimensional Weyl semimetal can generically support significant...
US20180024112 SYSTEMS AND METHODS FOR DETECTING METAL ION CONCENTRATIONS IN SUBJECTS  
A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a...
US20180024089 Nanoparticle-Based Gas Sensors and Methods of Using the Same  
Gas sensors are provided. The gas sensors include a gas sensing element having metal oxide nanoparticles and a thin-film heating element. Systems that include the gas sensors, as well as methods...
US20180024067 DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS  
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including...
US20180023137 Compositions, Devices, Systems, and Methods for Using a Nanopore  
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods...
US20180023136 Compositions, Devices, Systems, and Methods for Using a Nanopore  
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods...