Patents and Patent Applications from University of California System


Match Document Document Title
US20170116886 METHOD AND SYSTEM FOR TRAINING WITH FREQUENCY MODULATED SOUNDS TO ENHANCE HEARING  
A system and method is disclosed to enhance hearing employing a set of stimuli that collectively form a basis set for an auditory process comprising running a game engine on a processor of a...
US20170115323 NANOANTENNA SCANNING PROBE TIP, AND FABRICATION METHODS  
The invention provides a nanoantenna scanning probe tip for microscropy or spectroscopy. The nanoantenna scanning probe tip includes a sharp probe tip covered with a contiguous film of...
US20170114385 METHOD AND DEVICE FOR ISOLATING CELLS FROM HETEROGENEOUS SOLUTION USING MICROFLUIDIC TRAPPING VORTICES  
A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at...
US20170114364 Methods and Compositions for Localized Secretion of Anti-CTLA-4 Antibodies  
The present invention provides compositions and methods for effectuating the localized expression of anti-CTLA-4 antibody proximal to a target tissue in a patient.
US20170114360 TOMATO PLANTS COMPRISING TRANSGENIC EVENT BS2-X5  
The invention provides seed and plants of tomato comprising transgenic event Bs2-X5 and progeny thereof comprising this transgenic event and uses of such seeds and plants in the production of...
US20170114329 SCALABLE ORGANOTYPIC MODELS OF TUMOR DORMANCY  
Herein are described synthetic organotypic microvascular niches formed by self-assembly of stromal cells cultured endothelial cells seeded with cells of interest to model and determine dormancy...
US20170114130 ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF  
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further...
US20170114014 B-LACTAM COMPOUNDS  
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides.
US20170113046 SYSTEMS AND METHODS FOR RESTORING COGNITIVE FUNCTION  
Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial...
US20170113002 ADAPTIVE BRAIN-MACHINE INTERFACE SYSTEM FOR ANESTHESIA DELIVERY  
A system for controlling a state of anesthesia of a patient. The system includes a neural sensor configured to be coupled to a patient and generate an output signal indicative of neural activity...
US20170112899 POLYPEPTIDE-POLYMER CONJUGATES AND METHODS OF USE THEREOF  
The present invention provides polypeptide-polymer conjugates. A subject polypeptide-polymer conjugate is useful in a variety of applications, which are also provided.
US20170112634 Objective, Real-Time Acoustic Measurement and Feedback for Proper Fit and Fill of Hip Implants  
The present invention relates to a system and method for objective, real-time acoustic measurement and feedback for proper fit and fill of hip implants during total hip replacement surgery, or...
9634737 Periodic near field directors (PNFD) for short-range milli-meter-wave-wireless-interconnect (M2W2-interconnect)  
Periodic near field directors (PNFDs) are coupled to a transmitter and a receiver for a short-range millimeter wave wireless (M2W2) interconnect for transmitting and receiving radio frequency (RF)...
9632187 Modular positron emission tomography kit  
Systems and methods for a positron emission tomography (PET) kit are described. A PET detector kit may include a gantry, a plurality of PET detector modules, and an event processing device. A PET...
9632074 Compositions and methods for treating cancer and diseases and conditions responsive to cell growth inhibition  
In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing or preventing Growth Factor Inhibitor resistance in a cell, or, a method for increasing...
9632057 Ultra-sensitive gas sensors based on tellurium-single walled carbon nanotube hybrid nanostructures  
A gas sensor operable at ambient conditions, the sensor includes functionalized feather-like tellurium (Te) nanostructures on single-walled carbon nanotube (SWNTs) networks.
9631210 Methods for increasing production of 3-methyl-2-butenol using fusion proteins  
The present invention relates to methods and compositions for increasing production of 3-methyl-2-butenol in a de novo synthetic pathway in a genetically modified host cell using isopentenyl...
9631171 Microstructure biomaterials and fabrication methods therefor  
Methods and systems for fabricating a micro-structured biomaterial include printing a three-dimensional structure using polymerizing radiation modulated by a digital micromirror array to project...
9630914 Multitarget FAAH and COX inhibitors and therapeutical uses thereof  
Multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position...
9630161 Metal alloy nanoparticle synthesis via self-assembled monolayer formation and ultrasound  
Methods and assemblies for the construction of liquid-phase alloy nanoparticles are presented. Particle formation is directed by molecular self-assembly and assisted by sonication. In some...
9630008 Single channel cochlear implant artifact attenuation in late auditory evoked potentials  
Disclosed herein are embodiments of methods and systems for attenuating artifacts in single channel cochlear implants. Both high and low frequency artifacts can be attenuating using embodiments of...
9629911 Photoreactive regulator of protein function and methods of use thereof  
The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that...
9629860 Acyclic nucleoside phosphonate diesters  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
9629843 MTOR modulators and uses thereof  
The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in...
US20170110717 NANOPOROUS TIN POWDER FOR ENERGY APPLICATIONS  
A nanoporous tin is disclose, along with a method of fabrication thereof, the tin having a hierarchical nanoporous and mesoporous ligament morphology that exhibits long-term cyclability,...
US20170110714 Electrochemical deposition of refined lithium metal from polymer electrolytes  
A method for electrochemical deposition of refined lithium metal to form a lithium anode in situ in a lithium (Li) ion battery comprising providing a fully lithiated cathode, providing a metal...
US20170110338 Near-Unity Photoluminescence Quantum Yield in MoS2  
Two-dimensional (2D) transition-metal dichalcogenides have emerged as a promising material system for optoelectronic applications, but their primary figure-of-merit, the room-temperature...
US20170109881 AUTOMATED SEGMENTATION OF ORGAN CHAMBERS USING DEEP LEARNING METHODS FROM MEDICAL IMAGING  
Systems and methods are disclosed for automatically segmenting a heart chamber from medical images of a patient. The system may include one or more hardware processors configured to: obtain image...
US20170108392 DROPLET-BASED CAPACITIVE PRESSURE SENSOR  
A pressure sensing apparatus which utilizes an electrolytic droplet retained between a first and second sensing electrode within a housing. Contact between the electrolyte droplet and the...
US20170107558 Assessment Of Blood Coagulation Using An Acoustic Radiation Force Based Optical Coherence Elastography (ARF-OCE)  
An apparatus and method of using an optical coherence elastography (OCE) under acoustic radiation force (ARF) excitation includes the steps of inducing an excitation wave in a blood sample by use...
US20170107523 METHODS FOR PRODUCING MICROCOMPARTMENTS  
To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that...
US20170107519 METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
US20170107507 SINGLE CELL MICROFLUIDIC DEVICE  
Methods of non-destructively obtaining the genotype of a plant cell from a plant sample are disclosed. The plant cell is isolated from a plant cell sample using an integrated microfluidic device....
US20170107265 MET E 1 TROPOMYOSIN VARIANTS FOR USE IN ALLERGEN-SPECIFIC IMMUNOTHERAPY  
The present invention provides isolated Met e 1 polypeptides and nucleic acids encoding the isolated polypeptides that can prevent and/or alleviate an allergic response to shellfish tropomyosin....
US20170107261 Chemically Activated Nanocapsid Functionalized for Cancer Targeting  
Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of...
US20170107199 SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION  
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions...
US20170106100 CYCLODEXTRINS WITH ONE OR MORE POLY(ETHYLENE GLYCOL) UNITS, INCLUSION COMPOUNDS AND DRUG DELIVERY VEHICLES INCLUDING THE SAME, AND METHODS OF MAKING AND USING THE SAME  
A compound comprising a cyclodextrin and a monoalkoxy polyethylene glycol linked thereto through an ether bond (a “pegylated cyclodextrin”) is disclosed, as are drug delivery vehicles and...
US20170106085 COMPOSITIONS COMPRISING ANTI-CD38 ANTIBODIES AND CARFILZOMIB  
Disclosed herein are compositions and kits which comprise anti-CD38 antibodies and carfilzomib compounds. Also disclosed are methods for treating cancers, such as multiple myeloma, in subjects...
US20170106017 METHODS AND COMPOSITIONS FOR TREATMENT OF MACROPHAGE-RELATED DISORDERS  
Provided herein are methods and composition for the treatment for macrophage-related disorders, for example through the use of biomarkers for selection of responders and treatment monitoring.
US20170105673 Methods for Solubilizing Cells and/or Tissue  
Solubilizing compositions are provided. The compositions comprise at least one zwitterionic surfactant and at least one nonionic surfactant. In one embodiment, the compositions may be useful for...
US20170105653 BIO-IMPEDANCE MEASUREMENT METHOD USING BI-PHASIC CURRENT STIMULUS EXCITATION FOR IMPLANTABLE STIMULATOR  
Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and...
US20170105650 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS  
An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and...
US20170105407 COMPOSITIONS AND METHODS FOR ENHANCING RED BLOOD CELL STORAGE TIME AND SURVIVABILITY USING NITRIC OXIDE RELEASING HYBRID HYDROGEL NANOPARTICLES  
Described herein are hydrogel-based nanoparticles which release nitric oxide (NO) or other bioactive forms of NO including nitrosothiols, nitrofatty acids and dinitrogen trioxide into stored red...
9629232 Thermally actuated printed circuit board retainers  
Thermally actuated printed circuit board (PCB) retainer assemblies that utilize at least one thermally actuated element to secure a received PCB to a heat sink in accordance with embodiments of...
9628783 Method for interacting with virtual environment using stereoscope attached to computing device and modifying view of virtual environment based on user input in order to be displayed on portion of display  
A virtual reality hardware and software platform comprised of a stereoscope which attaches to a mobile touchscreen computer/tablet. The stereoscope, in which the user looks through, covers just...
9627485 Vapor-trapping growth of single-crystalline graphene flowers  
A method for growing a graphene layer on a metal foil includes placing a vessel into a chemical vapor deposition chamber, the vessel having a metal foil positioned therein. The method includes...
9625819 Photolithography on shrink film  
Provided are methods of preparing a plurality of extrusions, comprising (a) shrinking a transparent first thermoplastic material comprising a plurality of non-transparent marks, (b)...
9625387 System and method for controlling depth of imaging in tissues using fluorescence microscopy under ultraviolet excitation following staining with fluorescing agents  
The present disclosure relates to a method for analyzing tissue specimens. In one implementation the method involves obtaining a tissue sample and exposing the sample to one or more fluorophores...
9625351 Coherent dual parametric frequency comb for ultrafast chromatic dispersion measurement in an optical transmission link  
A wide-band optical frequency comb is provided to estimate an optical phase shift induced in a dispersive material. In contrast to the conventional techniques that rely on a single tunable laser...
9625320 Automatically locked homodyne detection  
Systems and techniques relating to automatically-locked homodyne detection are described. A described system includes a first nonlinear element, a filter, and second nonlinear elements. The first...