Patents and Patent Applications from University of California System


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US20170022487 SYNTHETIC CATALYTIC MIMICS OF ESTERASES, LIPASES OR DESATURASES  
Novel synthetic catalytic structures or “synzymes,” e.g., fatty acid modified polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic...
US20170022384 Aqueous Dispersion of Hydrophobically Modified Pigment Particles  
The present invention relates to a composition comprising a) a stable aqueous dispersion of inorganic pigment particles hydrophobically modified with covalently bonded polysiloxane or silyl...
US20170022244 BONE-SELECTIVE OSTEOGENIC OXYSTEROL BISPHOSPHONATE ANALOGS  
Oxysterol-bisphosphonate and oxysterol-alendronic acid compounds, compositions including them, and methods using them for the treatment of bone disorders.
US20170022135 METHODS FOR AMELIORATING AND PREVENTING CENTRAL NERVOUS SYSTEM INFLAMMATION  
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated...
US20170021056 PEPTIDE AMPHIPHILE BIOMATERIALS FOR NERVE REPAIR  
Provided herein are compositions comprising aligned peptide amphiphile biomaterials, methods of generating such alignment, and their use in nerve repair applications. In particular, peptide...
US20170021013 D-AMINO ACID DERIVATIVE-MODIFIED PEPTIDOGLYCAN AND METHODS OF USE THEREOF  
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using...
US20170020798 HESPERIDIN-CONTAINING COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISORDERS  
Compositions and methods for treating aged skin or skin otherwise suffering from abnormal epidermal barrier function are disclosed, where the compositions include hesperidin.
US20170020387 OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM WITH PHASE-SENSITIVE B-SCAN REGISTRATION  
This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan...
US20170020140 Synergy-Based Biocontrol of Plant Pathogens  
Methods and compositions are provided for control of pathogenic fungal or oomycetous infection.
9554348 Timing synchronization of wireless networks  
A single wireless slave node may be in a timing virtual network (TVN) with neighboring wireless slave nodes. The single wireless slave node may store information indicative of the identity, link...
9551722 Amyloid binding agents  
There are provided compounds and methods for the detection of amyloids and treatment of diseases related to amyloids including Alzheimer's disease and other related amyloid-based neurodegenerative...
9551667 Method for amplification-free nucleic acid detection on optofluidic chips  
An optofluidic platform is constructed so as to comprise a planar, liquid-core integrated optical waveguides for specific detection of nucleic acids. Most preferably, the optical waveguides...
9551088 Method for growing group III-nitride crystals in supercritical ammonia using an autoclave  
A method of growing high-quality, group-III nitride, bulk single crystals. The group III-nitride bulk crystal is grown in an autoclave in supercritical ammonia using a source material or nutrient...
9550980 Composition and methods for the production of L-homoalanine  
Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral...
9550827 Methods for ameliorating and preventing central nervous system inflammation  
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated...
9550803 Method to improve antiviral activity of nucleotide analogue drugs  
An amino acid conjugate of a cyclic or acyclic nucleoside phosphonate is provided. In some cases, the amino acid conjugate is a tyrosine alkyl amide phosphonate ester conjugate of a cyclic or...
9549954 Method and composition for inducing human pluripotent stem cells  
The present invention provides a fibromodulin (FMOD) reprogrammed (FReP) cell and a method of making therefor, a culture medium therefor, and a supernatant thereof, and methods of making and using...
9549905 Treatment of inflammatory and infectious skin disorders  
Disclosed herein is a composition comprising of resveratrol and/or derivatives thereof and/or functionally related compounds and benzoyl peroxide and/or derivatives thereof and/or functionally...
9549684 System and method for reconstructing cardiac signals associated with a complex rhythm disorder  
Reconstruction of cardiac information representing a complex rhythm disorder is facilitated by assigning activation onsets to non-discernible beats in low confidence signals based upon time...
9549509 GLK genes for improved fruit quality  
The present invention provides methods for improving fruit quality in plants that have low or reduced levels of Golden2-like (GLK) activity in the green fruit (e.g., cultivated tomato). The...
US20170019178 NONLINEARITY CANCELLATION IN FIBER OPTIC TRANSMISSION BASED ON FREQUENCY-MUTUALLY-REFERENCED CARRIERS  
A system and method for mitigating nonlinearity in an optical communication link with multiple carriers uses mutual frequency referencing to stabilize at least a portion of the multiple carriers....
US20170018725 FLEXIBLE ORGANIC TRANSISTORS WITH CONTROLLED NANOMORPHOLOGY  
An organic device, including semiconducting polymers processed from a solution cast on one or more dielectric layers on a substrate; and electrical contacts to the semiconducting polymers, wherein...
US20170018205 PHYSICAL DEFORMABLE LUNG PHANTOM WITH SUBJECT SPECIFIC ELASTICITY  
A system and method to integrate computational fluid dynamics (CFD) and radiotherapy data for accurate simulation of spatio-temporal flow and deformation in real human lung is presented. The...
US20170017879 MEMRISTIVE NEUROMORPHIC CIRCUIT AND METHOD FOR TRAINING THE MEMRISTIVE NEUROMORPHIC CIRCUIT  
A neural network is implemented as a memristive neuromorphic circuit that includes a neuron circuit and a memristive device connected to the neuron circuit. An input voltage is sensed at a first...
US20170017877 MEMRISTIVE NEUROMORPHIC CIRCUIT AND METHOD FOR TRAINING THE MEMRISTIVE NEUROMORPHIC CIRCUIT  
A neural network is implemented as a memristive neuromorphic circuit that includes a neuron circuit and a memristive device connected to the neuron circuit. A conductance balanced voltage pair is...
US20170017581 Communication Efficient Secret Sharing  
Methods for distributed storage in accordance with embodiments of the invention enable secret sharing. One embodiment includes encoding source data using an encoding system to produce a plurality...
US20170016885 COMPOSITIONS AND METHODS FOR MEASURING CELLULAR MECHANICAL STRESS  
Provided are compositions and methods employing cells encapsulated within and attached to a hydrogel, e.g., for measuring mechanical strain and/or stress of the cell and for investigating the...
US20170016877 APPARATUS AND METHOD FOR ELECTRICAL DETECTION OF OLIGONUCLEOTIDES THROUGH PORE BLOCKADES  
Systems and methods for specific nucleic acid (NA) sequence detection that do not rely on polymerase chain reaction (PCR) for target sequence amplification and do not require any special reagents...
US20170016742 METHOD OF FABRICATING MICRO-GLASSBLOWN GYROSCOPES  
A method of making a Coriolis vibratory gyroscope with a three dimensional mushroom resonator element includes defining a cavity in a substrate wafer; bonding a cap wafer onto the substrate over...
US20170016040 CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS  
The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing...
US20170016034 Host cells and methods for producing diacid compounds  
The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an α,ω-dicarboxylic acids (DCAs) and/or mono-methyl ester...
US20170016016 AGENTS FOR ENHANCEMENT OF PRODUCTION OF BIOFUEL PRECURSORS IN MICROALGAE  
We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and...
US20170015990 HYBRID POLYKETIDE SYNTHASES  
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell...
US20170015730 POLYPEPTIDE COMPOSITIONS WITH TYPE VII COLLAGEN FIBRONECTIN TYPE III-LIKE REPEATS AND TREATMENT METHODS FOR WOUND CLOSURE AND HEALING  
Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a...
US20170015714 Synthetic Polypeptide Having A Xylose Import Activity  
This disclosure provides methods and compositions related to microbial gene expression. In one aspect, a synthetic polypeptide having a xylose import activity.
US20170014817 DEHYDROGENATION OF NEAT FORMIC ACID  
A formic acid decomposition catalyst system includes metal-ligand complexes having formula 1: wherein M is a transition metal; R1, R2 are independently C1-6 alkyl groups; o is 1, 2, 3, or 4; R3...
US20170014803 USE OF MANGANESE OXIDE AND ACTIVATED CARBON FIBERS FOR REMOVING A PARTICLE, VOLATILE ORGANIC COMPOUOND OR OZONE FROM A GAS  
The present invention provides for a device for reducing a volatile organic compound (VOC) content of a gas comprising a manganese oxide (MnOx) catalyst. The manganese oxide (MnOx) catalyst is...
US20170014630 SITE SPECIFIC DEEP BRAIN STIMULATION FOR ENHANCEMENT OF MEMORY  
The various embodiments described herein include methods, devices, and systems for enhancement of memory. In one aspect, a method includes: (1) implanting intracranial electrodes in a patient,...
US20170014460 INHIBITION OF HYPOXIA-INDUCIBLE FACTOR ACTIVITY WITH CARICA PAPAYA EXTRACTS  
An extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed is used as an inhibitor of HIF to effectively block...
US20170014399 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES  
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
9546193 Compositions and methods for 18F-fluorodeoxyglycosylamines  
Various compositions and methods for Quasi-Amadori products and derivatives thereof are contemplated in which a halogenated carbohydrate is reacted with a primary amino group of an affinity...
9545461 Anti-microbial peptides and methods of use thereof  
The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.
9545422 Methods of inducing photosensitivity by targeting channelrhodopsin-2 and halorhodopsin to subcellular regions of retinal ganglion cells  
The present disclosure provides neuromodulators, nucleic acid encoding thereof, and compositions thereof for endowing visual processing abilities to neuronal cells. The present disclosure further...
US20170012614 CURRENT-MODE CLOCK DISTRIBUTION  
Current-mode signaling for a one-to-many clock signal distribution providing significantly less dynamic power use and improved noise immunity compared to traditional VM signaling schemes.
US20170011763 DATA STORAGE DEVICES AND METHODS WITH FREQUENCY-SHAPED SLIDING MODE CONTROL  
A data storage device includes a disk, a head, a microactuator, a coarse actuator, and a servo controller. The microactuator is configured to position the head relative to the disk. The coarse...
US20170010483 BROADBAND METACOAXIAL OPTICAL NANOANTENNAS BASED ON PLASMONIC MODES  
Techniques, systems, and devices are disclosed for implementing nanostructures in the optical domain that highly localize the incident electromagnetic field to with a large spectral range from the...
US20170009274 SEQUENCING OF NUCLEIC ACIDS VIA BARCODING IN DISCRETE ENTITIES  
Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods...
US20170008915 ACID, SOLVENT, AND THERMAL RESISTANT METAL-ORGANIC FRAMEWORKS  
The disclosure provides for thermal, solvent, and/or acid resistant metal organic frameworks and the use of these frameworks in devices and methods for gas separation, gas storage, and catalysis....
US20170007831 TRANSCUTANEOUS SPINAL CORD STIMULATION: NONINVASIVE TOOL FOR ACTIVATION OF LOCOMOTOR CIRCUITRY  
This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering...
US20170007737 AMELOGENIN-CHITOSAN HYDROGEL FOR DENTIN HYPERSENSITIVITY  
A method to regrow a protective layer over exposed/demineralized dentin that includes a step of identifying a subject having exposed/demineralized dentin. The demineralized dentin is contacted...