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Patents and Patent Applications from University of California System


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US20140315805 LOCALLY RELEASED GROWTH FACTORS TO MEDIATE MOTOR RECOVERY AFTER STROKE  
Methods of improving recovery of a mammal after an ischemic event (e.g., stroke) are provided. In various embodiments the methods involve administering a neural growth factor (e.g., BDNF) into the...
US20140315723 Tunnel Junction Fabrication  
A method for fabricating a tunnel junction includes depositing a first electrode on a substrate, depositing a wetting layer having a thickness of less than 2 nm on the first electrode, using atomic...
US20140315308 GLUCOMANNAN SCAFFOLDING FOR THREE-DIMENSIONAL TISSUE CULTURE AND ENGINEERING  
The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also...
US20140315287 SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES  
A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a...
US20140315195 METHOD FOR EXOSOMAL BIOMARKER DETECTION BY ELECTRIC FIELD-INDUCED RELEASE AND MEASUREMENT  
The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome...
US20140314698 ALDEHYDE DEHYDROGENASE INHIBITORS AS NOVEL DEPIGMENTING AGENTS  
The present invention provides methods and compositions for reducing pigmentation.
US20140313510 MULTIPLEX FLUORESCENT PARTICLE DETECTION USING SPATIALLY DISTRIBUTED EXCITATION  
A chip-scale optical approach to performing multi-target detection is based on molecular biosensing using fiber-optic based fluorescence or light scattering detection in liquid-core waveguides....
US20140313507 OPTOFLUIDIC DEVICES AND METHODS FOR SENSING SINGLE PARTICLES  
This disclosure provides systems, methods, and apparatus related to optofluidic devices. In one aspect, an optofluidic device includes a substrate, a first nanostructure, a second nanostructure,...
US20140313310 METHODS FOR OPTICAL AMPLIFIED IMAGING USING A TWO-DIMENSIONAL SPECTRAL BRUSH  
An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode...
US20140312421 Vapor-Trapping Growth of Single-Crystalline Graphene Flowers  
A method for growing a graphene layer on a metal foil includes placing a vessel into a chemical vapor deposition chamber, the vessel having a metal foil positioned therein. The method includes...
US20140311481 Novel compositions and methods useful for ionic liquid treatment of biomass  
The present invention provides for novel compositions and methods for recycling or recovering ionic liquid used in IL pretreated cellulose and/or lignocellulosic biomass (LBM).
US20140311347 POLANILINE BASED MEMBRANES FOR SEPARATION OF CARBON DIOXIDE AND METHANE  
Various embodiments demonstrate that an in-situ polymerization enables deposition of a homogeneous polyaniline layer with a controlled thickness on top of a porous polypropylene support....
8868867 Method for reducing latency of accessing data stored in a file system on a computer storage device by caching file system permission information in the computer storage device  
Systems and methods of storage device access are provided, where the operating system copies permission and mapping information to the storage array and/or to the application program's memory. The...
8868169 Method and system for detection of biological rhythm disorders  
System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the...
8867831 Image enhancement using modulation strength map and modulation kernel  
An image enhancement system may generate a net signed fractional modulation value at each location in an image using a modulation strength map (MSM) in combination with a modulation kernel F(θ). ...
8867510 Methods and apparatus to utilize network coding in a wireless network  
Methods and apparatus to utilize network coding in a wireless network are disclosed. A disclosed example method includes receiving a first packet flow at a first node from a second node that is...
8866149 Method for the reuse of gallium nitride epitaxial substrates  
A method for the reuse of gallium nitride (GaN) epitaxial substrates uses band-gap-selective photoelectrochemical (PEC) etching to remove one or more epitaxial layers from bulk or free-standing GaN...
8866126 Anisotropic strain control in semipolar nitride quantum wells by partially or fully relaxed aluminum indium gallium nitride layers with misfit dislocations  
An epitaxial structure for a III-Nitride based optical device, comprising an active layer with anisotropic strain on an underlying layer, where a lattice constant and strain in the underlying layer...
8866063 Lens-free wide-field super-resolution imaging device  
A system for imaging objects within a sample includes an image sensor and a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor. The system further...
8865914 Fluorescent probes for detection of copper  
The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo...
8865873 Internalizing human monoclonal antibodies targeting prostate cancer cells in situ  
This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of...
8865719 Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors  
The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs and/or GABAA receptors. The invention also discloses the ...
8865708 Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase  
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are...
8865646 Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging  
The present invention relates to dietary compositions comprising reduced level of methionine, tryptophan, all amino acids, or protein, dietary compositions comprising glycerol as a substitute for...
8865469 Methods of transforming a Listeria  
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many...
8863773 Fluid metering device using free-moving piston  
A fluid metering device may meter the flow of fluid. The device may have a main chamber and a piston configured and oriented to reciprocate within the main chamber. The piston may be configured and...
US20140310837 Engineering Single-Gene-Controlled Staygreen Potential Into Plants  
The enzymes of the ACC synthase family are used in producing ethylene. Nucleotide and polypeptide sequences of ACC synthases are provided along with knockout plant cells having inhibition in...
US20140310495 COLLECTIVE MEMORY TRANSFER DEVICES AND METHODS FOR MULTIPLE-CORE PROCESSORS  
This disclosure provides systems, methods, and apparatus for collective memory transfers. A control unit may be configured to coordinate a transfer of data between a memory and processor cores. For...
US20140310467 MULTIPLE-CORE COMPUTER PROCESSOR FOR REVERSE TIME MIGRATION  
A multi-core computer processor including a plurality of processor cores interconnected in a Network-on-Chip (NoC) architecture, a plurality of caches, each of the plurality of caches being...
US20140309974 OPTIMIZATION OF INPUT PARAMETERS OF A COMPLEX SYSTEM BASED ON MULTIPLE CRITERIA  
A method of combinatorial optimization includes: (1) defining an objective function to optimize a combination of N input parameters of a complex system, wherein the objective function includes a...
US20140309579 BALLOON CATHETER METHOD FOR REDUCING RESTENOSIS VIA IRREVERSIBLE ELECTROPORATION  
Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The...
US20140309433 Cyclic Alkyl Amino Carbene (CAAC) Ruthenium Complexes as Improved Catalysts for Ethenolysis Reactions  
Described herein are compounds and methods of catalyzing ethenolysis reactions, optionally on an industrial scale. In certain embodiments, the catalysts bear cyclic alkyl amino carbene (CAAC)...
US20140309289 COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS, AND METHODS OF USE  
Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi;...
US20140309262 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES  
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
US20140309217 Controlled-Release CNS Modulating Compositions and Methods for the Treatment of Otic Disorders  
Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an...
US20140309124 METHODS FOR ASSESSING ATHEROGENESIS BY DETERMINING OXIDIZED PHOSPHOLIPID TO APOLIPOPROTEIN B RATIOS  
The present invention provides methods to analyze oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary...
US20140308769 METHOD OF IMPROVING SURFACE MORPHOLOGY OF (Ga,Al,In,B)N THIN FILMS AND DEVICES GROWN ON NONPOLAR OR SEMIPOLAR (Ga,Al,In,B)N SUBSTRATES  
A method for improving the growth morphology of (Ga,Al,In,B)N thin films on nonpolar or semipolar (Ga,Al,In,B)N substrates, wherein a (Ga,Al,In,B)N thin film is grown directly on a nonpolar or...
US20140308734 PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES  
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and...
US20140308714 DECREASED POLYSACCHARIDE O-ACETYLATION  
The disclosure relates to polypeptides and polynucleotides from multiple species related to the O-acetylation of polysaccharides in plants. The disclosure also describes plants with reduced...
US20140308686 BIOMARKER FOR ABDOMINAL AORTIC ANEURYSM  
Methods for detecting abdominal aortic aneurysm (AAA) or predisposition to AAA in a apoE subject, methods for monitoring the efficacy of treatment of AAA in a subject, and methods for evaluating...
US20140308683 Compositions and Methods for Determining Risk of a Cardiovascular Occlusive Event  
The present disclosure provides methods for assessing risk of a cardiovascular occlusive event in an individual. The methods find use in diagnostic and prognostic applications. The present...
US20140308381 CONTOUR CRAFTING EXTRUSION NOZZLES  
An automated extrusion construction system may include an extrusion nozzle configured to extrude construction material in a substantially horizontal direction against an elongated and substantially...
US20140308341 METHODS AND COMPOSITIONS FOR LIPOSOMAL FORMULATION OF ANTIGENS AND USES THEREOF  
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These...
US20140308337 Hemostatic Compositions and Methods of Use  
Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.
US20140308301 CD44 MONOCLONAL ANTIBODY FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER HEMATOLOGICAL MALIGNANCIES  
Compositions including an antibody specific for CD44 are provided. These antibodies specifically bind to hematologic malignant cells. Methods to use the CD44 antibodies to target cells expressing...
US20140308256 Methods for Use of Neural Stem Cell Compositions for Treatment of Central Nervous System Lesions  
Methods for inducing non-embryonic lesioned central nervous system neurons to survive, integrate, extend axons over long distances, induce intra-lesion ingrowth of neurons into the lesion from host...
US20140308208 CAGED COMPOUND DELIVERY AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength...
US20140306215 GENERATION OF HIGHLY N-TYPE, DEFECT PASSIVATED TRANSITION METAL OXIDES USING PLASMA FLUORINE INSERTION  
A new composition of matter is disclosed wherein oxygen vacancies in a semiconducting transition metal oxide such as titanium dioxide are filled with a halogen such as Fluorine, whereby the...
US20140305628 Device Useful as a Borehole Fluid Sampler  
The present invention provides a device comprising: (a) a proximal end of the device comprises an inner first conduit within the lumen of an outer second conduit, (b) a distal end of the device...
US20140305014 Graduation Mortarboard Display Holder  
A mortar board display holder comprises a board clip portion, a display supporter portion, and a connecting portion joining the board clip portion and the display supporter portion. The board clip...