Patents and Patent Applications from University of California System


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9435043 Oxygen evolution reaction catalysis  
An Oxygen Evolution Reaction (OER) catalyst includes a metal oxide that includes oxygen, cerium, and one or more second metals. In some instances, the cerium is 10 to 80 molar % of the metals in...
9435021 Co-deposition methods for the fabrication of organic optoelectronic devices  
A method for fabricating an OLED by preparing phosphorescent metal complexes in situ is provided. In particular, the method simultaneously synthesizes and deposits copper (I) complexes in an...
9434930 Method of producing dicer  
The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure...
9433686 Methods for treating castration resistant prostate cancer and metastasis by reducing B-cell number and/or function  
The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises...
9433219 Fungi antagonistic to xylella fastidiosa  
The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.
US20160254567 ELECTROLYTE STRUCTURE FOR METAL BATTERIES  
An electrolyte structure includes a metal organic framework (MOF) material defining a plurality of pores. Anions are bound to respective metal atoms of the MOF material. The bound anions are...
US20160254141 COPOLYMER FORMULATION FOR DIRECTED SELF-ASSEMBLY, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME  
Disclosed herein is a pattern forming method comprising providing a substrate devoid of a layer of a brush polymer; disposing upon the substrate a composition comprising a block copolymer...
US20160252517 BIOMOLECULAR INTERACTION DETECTION DEVICES AND METHODS  
Methods, systems, and devices are disclosed for detecting molecular interactions. In one aspect, a device includes a substrate formed of an electrically insulative material, the substrate...
US20160252514 METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS  
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell...
US20160252494 MICROSCALE MICROPATTERNED ENGINEERED IN VITRO TISSUE  
The disclosure provides an in vitro culture systems. The invention provides methods and systems useful for developing in vitro an engineered tissue, method of using the tissue and compositions...
US20160252471 NANOPARTICLE ASSISTED SCANNING FOCUSING X-RAY FLUORESCENCE IMAGING AND ENHANCED TREATMENT  
The present disclosure provides systems and methods for providing irradiation energy, imaging, and detecting X-ray fluorescence from a volume in a sample. The present disclosure further relates to...
US20160251718 Endometriosis Classifier  
The present disclosure provides methods and compositions that are useful for diagnosing the presence or absence of endometriosis and the severity of endometriosis in a subject. The methods and...
US20160251672 Modified plants and methods for producing modified lignin by modulating expression of acyltransferases  
The present invention provides for novel compositions and methods of producing modified lignin by modulating expression of acyltransferases.
US20160251539 COPOLYMER FORMULATION FOR DIRECTED SELF-ASSEMBLY, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME  
Disclosed herein is a pattern forming method comprising disposing upon a substrate a composition comprising a block copolymer; where the block copolymer comprises a first polymer and a second...
US20160251538 COPOLYMER FORMULATION FOR DIRECTED SELF-ASSEMBLY, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME  
Disclosed herein is a composition comprising a block copolymer; where the block copolymer comprises a first polymer and a second polymer; where the first polymer and the second polymer of the...
US20160251508 COPOLYMER FORMULATION FOR DIRECTED SELF-ASSEMBLY, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME  
Disclosed herein is a composition comprising a block copolymer; where the block copolymer comprises a first polymer and a second polymer; where the first polymer and the second polymer of the...
US20160250618 METAL-ORGANIC FRAMEWORKS WITH A HIGH DENSITY OF HIGHLY CHARGED EXPOSED METAL CATION SITES  
The disclosure provides for Metal-Organic Frameworks comprising M2(m-dobdc)-based cores, and methods of use thereof, including gas separation, gas storage, sensing, and other applications...
US20160250330 SCINTILLATOR NANOCRYSTAL-CONTAINING COMPOSITIONS AND METHODS FOR THEIR USE  
There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
US20160250211 AURORA KINASE INHIBITORS  
Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein.
US20160249976 BLADDER DENERVATION FOR TREATING OVERACTIVE BLADDER  
A device and method for transvaginal or transrectal treatment of a bladder pathology. The device includes an elongate body that includes a longitudinal axis, a handle at one end of the body, a...
9431919 Biomedical implant with a monolithic timing control based rectifier for multivoltage for biomedical applications  
A biomedical implant is provided for simultaneously generating multiple voltages for digital and analog circuits. Two AC voltages induced from an external single AC source located externally to...
9431201 Micromechanical resonant switches and charge pumps  
A circuit of N micromechanical resonant switches (resoswitches) is presented, which mimics a Dickson charge pump to amplify an input voltage to an output voltage of N plus 1 times the input...
9429428 Environmentally robust micro-wineglass gyroscope  
A method for fabricating an environmentally robust micro-wineglass gyroscope includes the steps of stacking and bonding of at least an inner glass layer and an outer glass layer to a substrate...
9428806 Apparatus and method for electrical detection of oligonucleotides through pore blockades  
Systems and methods for specific nucleic acid (NA) sequence detection that do not rely on polymerase chain reaction (PCR) for target sequence amplification and do not require any special reagents...
9428773 Methods of producing acetoin and 2,3-butanediol using photosynthetic microorganisms  
The present disclosure provides recombinant cyanobacteria having acetolactate synthase activity and acetolactate decarboxylase activity, as well as recombinant cyanobacteria having acetolactate...
9428726 Modified host cells with efflux pumps  
The present invention provides for a modified host cell comprising a heterologous expression of an efflux pump capable of transporting an organic molecule out of the host cell wherein the organic...
9428561 Polypeptide-polymer conjugates and methods of use thereof  
The present invention provides polypeptide-polymer conjugates. A subject polypeptide-polymer conjugate is useful in a variety of applications, which are also provided.
9428465 Acid ceramidase inhibitors and their use as medicaments  
The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds....
9427728 Use of manganese oxide and activated carbon fibers for removing a particle, volatile organic compound or ozone from a gas  
The present invention provides for a device for reducing a volatile organic compound (VOC) content of a gas comprising a manganese oxide (MnOx) catalyst. The manganese oxide (MnOx) catalyst is...
9427472 Controlled release compositions for modulating free-radical induced damage and methods of use thereof  
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an...
9427312 Accommodating intraocular composite lens and related methods  
An implantable intraocular lens and methods of manufacturing them provide a target degree of optical accommodation. In various embodiments, the lens includes at least one internal optic, an outer...
9427291 Orthodontic appliance with snap fitted, non-sliding archwire  
An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may...
9427147 Directional optical coherence tomography systems and methods  
An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence...
US20160248951 CELLSCOPE APPARATUS AND METHODS FOR IMAGING  
An improved system and methods for enhancing the imaging of cameras included with wireless mobile devices, such as cellular phone or tablets. The imaging system includes a releasable optical...
US20160248084 DURABLE CARBON-COATED LI2S CORE-SHELL MATERIALS FOR HIGH PERFORMANCE LITHIUM/SULFUR CELLS  
The disclosure provides methods for producing uniformly sized lithium sulfide materials which are coated with one or more durable and conductive carbon shells that impede the polysulfide shuttle....
US20160247593 CONDUCTIVE OPEN FRAMEWORKS  
The disclosure relates generally to materials that comprise conductive covalent organic frameworks. The disclosure also relates to materials that are useful to store and separate gas molecules and...
US20160247312 PHYSICS-BASED HIGH-RESOLUTION HEAD AND NECK BIOMECHANICAL MODELS  
Systems and methods are shown for developing physics-based high resolution biomechanical head and neck deformable models for generating ground-truth deformations that can be used for validating...
US20160246919 PREDICTIVE OPTIMIZATION OF NETWORK SYSTEM RESPONSE  
A system includes a drug database, a disease gene database, and a network model describing a physiological or biological network. The network model receives drug data from the drug database...
US20160245822 MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS TO FACILITATE STRUCTURAL ANALYSIS OF PROTEINS AND PROTEIN COMPLEXES, AND METHOD OF USING SAME  
Novel cross-linking compounds that can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of proteins and protein...
US20160244435 EXPANDED THERAPEUTIC POTENTIAL IN NITROHETEROARYL ANTIMICROBIALS  
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to imidazole, thiazole, and furan derivatives and...
US20160243285 METHODS OF MAMMALIAN RETINAL STEM CELL PRODUCTION AND APPLICATIONS  
The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a...
US20160243281 HYALURONIC ACID AND ALGINATE HYDROGEL COMPOSITION  
A hydrogel composition comprising an alginate polymer and a hyaluronic acid polymer is a useful polymer scaffold for mammalian tissue engineering. To enable cell adhesion, adhesion peptides may be...
US20160243262 ENZYME-ENCAPSULATED NANOPARTICLE PLATFORM  
Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an...
US20160243250 TREATING INFLAMMATION USING LLP2A-BISPHOSPHONATE CONJUGATES AND MESENCHYMAL STEM CELLS  
The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an...
US20160243208 FUSION MOLECULE BASED ON NOVEL TAA VARIANT  
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines...
US20160243194 PUMA PROTEIN EXPRESSION VECTOR AND USE THEREOF IN GENE THERAPY  
The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector...
US20160243149 NOVEL ANTI-VIRAL THERAPEUTIC  
Anti-viral therapeutics for use in viral targets having VPg unlinkase activity, including the broad class of picornaviruses, and therapeutic methods directed at suppression of such activity are...
US20160243135 Compositions and Methods for Modification of Biomolecules  
The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be...
US20160243028 Auris Formulations for Treating Otic Diseases and Conditions  
Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and...
US20160242994 METHODS OF DIAGNOSING AND TREATING NEONATAL REVERSION TO FETAL CONSCIOUSNESS  
This invention provides methods of diagnosing and treating syndromes of reversion to fetal consciousness in a neonate.