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Patents and Patent Applications from University of California System


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US20140288170 META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS  
The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that...
US20140288150 DENDRONIZED POLYMERS FOR NUCLEIC ACID DELIVERY  
The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.
US20140288115 COMPOSITIONS AND METHODS FOR TREATING BRAIN CANCER  
It is discovered that noscapine is effective in treating temozolomide (TMZ)-resistant brain cancer. Provided are compositions and methods of treating brain cancer patients, in particular those that...
US20140288097 USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT  
The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an...
US20140288096 P13 KINASE ANTAGONISTS  
The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
US20140288087 NICHE TARGETING OF QUIESCENT CANCER STEM CELLS  
The disclosure provides methods for determining the self-renewal potential of a cancer stem cell (CSC), or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting...
US20140288000 DUAL REACTIVITY POTENT KUNITZ INHIBITOR OF FIBRINOLYSIS  
Compositions and methods are disclosed that relate to novel plasmin-inhibiting polypeptides that are structural variants of a human TFPI-2 Kunitz-type proteinase first inhibitor domain (KD1). The...
US20140287994 PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX  
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and...
US20140287961 ARRAY FOR DETECTING MICROBES  
The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a...
US20140287957 ISOTOPIC LABELING FOR THE MEASUREMENT OF GLOBAL PROTEIN LEVELS AND TURNOVER IN VIVO  
An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the...
US20140287497 Methods of Modulating Cold Sensory Perception  
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
US20140287426 ANTIBODY AND ANTIBODY MIMETIC FOR VISUALIZATION AND ABLATION OF ENDOGENOUS PROTEINS  
Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein...
US20140287389 SYSTEMS AND METHODS FOR REAL-TIME ADAPTIVE THERAPY AND REHABILITATION  
Virtual reality-based adaptive systems and methods are disclosed for improving the delivery of physical therapy and rehabilitation. The invention comprises an interactive software solution for...
US20140286865 SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM  
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active...
US20140286367 NANOPILLAR PHOTONIC CRYSTAL LASERS  
A nanopillar photonic crystal laser includes a plurality of nanopillars and a support structure in contact with at least a portion of each of the nanopillars. Each nanopillar has an axial dimension...
US20140285272 Computer Aided Fabrication Systems  
A technique for implementing an clock tree distribution network having a clock buffer and a plurality of LC tanks that each take into \consideration local capacitance distributions and conductor...
US20140285061 THERMOMECHANICAL CYCLE FOR THERMAL AND/OR MECHANICAL ENERGY CONVERSION USING PIEZOELECTRIC MATERIALS  
A system for generating electrical energy includes a thermal source, an electric field source, a stress source, a piezoelectric component, and a cycle controller coupled to the thermal source, the...
US20140284207 FILTERS FOR BLOCKING MACROPARTICLES IN PLASMA DEPOSITION APPARATUS  
This disclosure provides systems, methods, and apparatus related to blocking macroparticles in deposition processes utilizing plasmas. In one aspect, an apparatus includes a cathode, a substrate...
8842901 Compact automated semen analysis platform using lens-free on-chip microscopy  
A compact and light-weight lens-free platform to conduct automated semen analysis is disclosed. The device employs holographic on-chip imaging and does not require any lenses, lasers or other bulky...
8842688 Reducing cabling complexity in large-scale networks  
High speed switching networks can be created with a minimum of cabling complexity using pod switches that are connected to a core switch array. Each pod switch can include line cards arranged in...
8842118 Automated image replacement using deformation and illumination estimation  
A method which makes it possible to replace a reference pattern (aka texture) on a video of clothing is described. For example, a video of a T-shirt with the text “UCLA” could be edited to say “UC...
8841739 Systems and methods for implementing magnetoelectric junctions  
Embodiments of the invention implement DIOMEJ cells. In one embodiment, a DIOMEJ cell includes: an MEJ that includes, a ferromagnetic fixed layer, a ferromagnetic free layer, and a dielectric layer...
8841691 Light emitting diode structure utilizing zinc oxide nanorod arrays on one or more surfaces, and a low cost method of producing such zinc oxide nanorod arrays  
A method of fabricating a Light Emitting Diode with improved light extraction efficiency, comprising depositing a plurality of Zinc Oxide (ZnO) nanorods on one or more surfaces of a III-Nitride...
8841471 Open metal organic frameworks with exceptional surface area and high gas storage capacity  
The disclosure provides metal organic frameworks comprising exception porosity.
8841350 Method for inducing UDP-glucuronosyltransferase activity using pterostilbene  
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the...
8841258 Methods to accelerate tissue and wound healing rates and reduce swelling and scar formation  
The present disclosure serves to reduce the healing time of tissue wounds, including those formed during surgery, whether necessary or elective (including cosmetic surgery), by providing a...
8841170 Methods for scribing of semiconductor devices with improved sidewall passivation  
A method of singulating semiconductor devices in the close proximity to active structures by controlling interface charge of semiconductor device sidewalls is provided that includes forming a...
8841116 Inline-injection microdevice and microfabricated integrated DNA analysis system using same  
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including...
8841072 Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores  
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
8840816 Making nanocrystalline mesoporous spherical particles  
Spherical particles of one or more elemental metals and carbon are prepared from a precursor in the form of a metal oleate. The metal oleate precursor is dispersed in a liquid vehicle and aerosol...
8840688 Chemical protection of metal surface  
An electrochemical cell includes an anode having a metal material having an oxygen containing layer. The electrochemical cell also includes a cathode and an electrolyte. The anode includes a...
US20140281243 MULTIPLE-CORE COMPUTER PROCESSOR  
A multi-core computer processor including a plurality of processor cores interconnected in a Network-on-Chip (NoC) architecture, a plurality of caches, each of the plurality of caches being...
US20140279944 SQL QUERY TO TRIGGER TRANSLATION FOR MAINTAINING CONSISTENCY OF CACHE AUGMENTED SQL SYSTEMS  
An SQL query-to-procedure translation system may be used in connection with a relational database management system (RDBMS) that is augmented by a cache and a cache management system that manages...
US20140279818 GAME THEORY MODEL FOR PATROLLING AN AREA THAT ACCOUNTS FOR DYNAMIC UNCERTAINTY  
Game theory models may be used for producing a strategy and schedule for patrolling an area like a rail transportation system. In some instances, the model may account for events that cause a...
US20140277765 HUMAN-BUILDING INTERACTION FRAMEWORK FOR PERSONALIZED COMFORT DRIVEN SYSTEM OPERATIONS IN BUILDINGS  
A computer data processing system may provide control information for controlling how an environmental control system controls an environment within a building. The computer data processing system...
US20140277629 POLYHEDRAL PHYSICAL AND ATHLETIC TRAINING MODULE, METHODS OF MAKING AND USING THE SAME, AND COACHING AND TRAINING SYSTEMS INCLUDING THE SAME  
A training module, training system, and methods of monitoring physical activity and making a training module are disclosed. The training module includes a compressible article having a polyhedral...
US20140277414 PERCUTANEOUS HEART VALVE DELIVERY SYSTEMS  
Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment...
US20140277293 METHODS FOR IN VITRO INHIBITION OF FIBROBLAST PROLIFERATION  
Methods for LED generated low-level light therapy (LLLT) in the red, blue, and IR ranges are described to effectively inhibit fibroblast proliferation in vitro without altering viability, and may...
US20140277273 SYSTEMS AND METHODS FOR SELECTIVELY MIGRATING CELLS USING ELECTRIC FIELDS  
Systems and methods are provided for migrating cells implanted or endogenous in tissue. The system may include first and second delivery electrodes configured for insertion in tissue and a direct...
US20140276152 SYSTEM AND METHOD TO IDENTIFY SOURCES ASSOCIATED WITH BIOLOGICAL RHYTHM DISORDERS  
A system and method of identifying a driver of a source associated with a heart rhythm disorder are disclosed. Data is accessed from a plurality of sensors representing biological activity in the...
US20140276148 NEWBORN HEART RATE MONITOR  
A newborn heart rate monitor is disclosed comprising a sensor integrated into a clamp configured to clamp onto the umbilical cord of a newborn infant. The sensor is configured to detect radial...
US20140276008 IMAGING SYSTEM AND METHOD FOR FLUORESCENCE GUIDED SURGERY  
Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection...
US20140275774 Delivery Catheter  
A catheter device is useful in a procedure in which an injectable material or device is injected into a tissue of a patient. In one implementation, for example, the catheter device is useful in...
US20140275773 Delivery Catheter for Injecting a Substrate into a Tissue  
A catheter device is useful in a procedure in which an injectable material or device is injected into a tissue of a patent. In one implementation, for example, the catheter device is useful in...
US20140275532 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
US20140274972 Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone  
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.
US20140274959 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
US20140274876 CARIES RISK TEST FOR PREDICTING AND ASSESSING THE RISK OF DISEASE  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
US20140274700 MOLECULES THAT INDUCE DISEASE RESISTANCE AND IMPROVE GROWTH IN PLANTS  
Described herein are methods and compositions for enhancing pathogen immunity in plants and improving plant growth.
US20140274699 MOLECULES THAT INDUCE DISEASE RESISTANCE IN PLANTS  
Described herein are methods and compositions for enhancing pathogen immunity in plants and improving plant growth.