Patents and Patent Applications from University of California System


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9382584 Methods and systems for direct sequencing of single DNA molecules  
The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine,...
9382553 Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound  
The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP...
9382387 Rapid self-assembly of block copolymers to photonic crystals  
The invention provides a class of copolymers having useful properties, including brush block copolymers, wedge-type block copolymers and hybrid wedge and polymer block copolymers. In an...
9382230 Methods and compositions for modulating Ire1, SRC and ABL activity  
Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the...
9381355 Ultra-high photosensitivity vertical nanowire arrays for retinal prosthesis  
A prosthetic retina for implantation in an eye having a defective retina is formed from an array of nanowires having a predetermined spatial distribution, density, size and shape implanted in...
9381236 Interferon-β production modulating listeria strains and methods for using same  
Mutant Listeria bacteria that modulate interferon-β production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR...
9381185 Methods of inducing sedation  
The present invention provides methods of inducing sedation in a subject by administering an effective amount of a compound or a mixture of compounds according to Formula I. Compounds of Formula I...
9380950 Methods for detecting biological rhythm disorders  
A method of detecting a cause of a heart rhythm disorder includes collecting data corresponding to activation onset time of each heart activation at multiple locations of the heart and generating...
US20160192459 HOUSEHOLD APPLIANCE THAT DYNAMICALLY CONTROLS SPECTRAL ILLUMINATION TO ENHANCE WAY-FINDING AND DARK-ADAPTATION  
The disclosed embodiments relate to a household appliance (such as a refrigerator, stove, microwave, toaster, oven, dishwasher, clothes washer and clothes dryer) that includes exterior and/or...
US20160190030 SELF-LIMITING CHEMICAL VAPOR DEPOSITION AND ATOMIC LAYER DEPOSITION METHODS  
Methods for depositing silicon on a semiconductor or metallic surface include cycling dosing of silane and chlorosilane precursors at a temperature between 50° C. and 300° C., and continuing...
US20160189803 FORMATION OF A FIELD REVERSED CONFIGURATION FOR MAGNETIC AND ELECTROSTATIC CONFINEMENT OF PLASMA  
A system and method for containing plasma and forming a Field Reversed Configuration (FRC) magnetic topology are described in which plasma ions are contained magnetically in stable, non-adiabatic...
US20160189044 Traffic Prediction Using Real-World Transportation Data  
Real-time high-fidelity spatiotemporal data on transportation networks can be used to learn about traffic behavior at different times and locations, potentially resulting in major savings in time...
US20160187350 CLEAVABLE PROBES FOR ISOTOPE TARGETED GLYCOPROTEOMICS AND METHODS OF USING THE SAME  
Methods for producing isotopically-labelled peptides are provided. Aspects of the method include: contacting a sample including a metabolically tagged protein with a cleavable probe to produce a...
US20160187346 PYRITE SHRINK-FILM LAMINATE AS A HYDROXYL RADICAL GENERATOR  
Disclosed are hydroxyl radial generating devices, comprising: a substrate layer; and a pyrite layer configured to produce hydroxyl radicals. Another aspect relates to a method for producing a...
US20160185862 CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF  
The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure...
US20160185723 C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE  
The present invention provides compositions and methods for the selective C—H fluorination of nitrogen-containing heteroarenes with AgF2, which has previously been considered too reactive for...
US20160184824 HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS  
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated...
US20160184596 MINIMALLY INVASIVE IMPLANTABLE BRAIN STIMULATION DEVICES AND METHODS FOR IMPLANTING SAME  
A brain stimulation device includes: a threaded head portion; a needle portion connected to the threaded head portion; at least one wireless power source arranged in proximity to the threaded head...
US20160184478 SOLUBILIZATION OF ANTIGEN COMPONENTS FOR REMOVAL FROM TISSUES  
The present invention relates to methods for removing antigens from tissues by sequentially destabilizing and/or depolymerizing cytoskeletal components and removing and/or reducing water-soluble...
US20160184461 FUNCTIONALIZED MAGNETIC NANOPARTICLES AND USE IN IMAGING AMYLOID DEPOSITS AND NEUROFIBRILLARY TANGLES  
The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure...
US20160184394 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20160184365 PLACENTA-DERIVED MULTIPOTENT STEM CELLS  
This disclosure provides isolated cells and compositions comprising one or more isolated cell(s) as described herein. In one aspect, the isolated cell is a pre-term placenta-derived stem cell...
US20160184349 Citrate Containing Beverage  
Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may...
US20160183840 Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties  
A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating...
US20160183778 MINIMALLY OBSTRUCTIVE COMPACT SPECULUM  
Medical instruments, particularly structurally-adjustable speculums and retractors for obstetrical and gynecological operations, procedures, and examinations, including a minimally obstructive...
PP26871 Peach tree named ‘Kader’  
A new peach variety (Prunus persica) designated as ‘Kader’ is provided. ‘Kader’ forms attractive, high quality fruit that matures approximately six to ten days earlier than that of the ‘Andross’...
9379422 Hydrogen-treated semiconductor metal oxides for photoelectrical water splitting  
A method of electrode hydrogenation for photoelectrochemical (PEC) water oxidation is provided that includes annealing a PEC electrode in air, and annealing the PEC electrode in hydrogen to form a...
9379335 Benzodipyrrolidones and their polymers: synthesis and applications for organic electronics and optoelectronics  
Disclosed is the synthesis of benzodipyrrolidone and their polymers and small molecules for electronic and optoelectronic applications. Also disclosed are devices that incorporate such polymers...
9377426 Selective nanoscale asymmetric gas sensors  
A selective nanoscale asymmetric gas sensor is disclosed, the sensor including a first electrode having a Schottky-type contact to a nanoengineered transducer with a barrier height between energy...
9377002 Electrodes for multi-point ignition using single or multiple transient plasma discharges  
A device for providing ignition of a fuel-air mixture using a transient plasma discharge is provided. The device includes an anode coupled to receive a voltage; and a cathode disposed in proximity...
9376728 Useful halophilic, thermostable and ionic liquids tolerant cellulases  
The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a Halorhabdus utahensis...
9376691 Fusion proteins useful for producing pinene  
The present invention provides for a modified host cell comprising a heterologous pinene synthase (PS), or enzymatically active fragment or variant thereof, and optionally a geranyl pyrophosphate...
9376662 Increasing cell culture population doublings for long-term growth of finite life span human cell cultures  
Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human...
9376516 Porous polymer structures and methods and articles relating thereto  
A porous polymer structure may be formed by cooling a substrate to a temperature at or below a freezing point of a monomer, wherein the monomer is capable of free-radical polymerization; exposing...
9376481 Methods of promoting CNS neuronal repair by inhibiting LRP-1  
This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein...
9376423 PKC-epsilon inhibitors  
The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I or II or a stereoisomer, tautomer, racemic, metabolite, pro- or pre-drug, salt, hydrate, or...
9375313 Intramyocardial patterning for global cardiac resizing and reshaping  
Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into...
9375156 System for analysis of complex rhythm disorders  
A system to detect a cause of a complex rhythm disorder in a human heart includes a plurality of sensors disposed spatially in relation to the heart, where the signals generated by the sensors are...
9374950 System and methods for monitoring leaf temperature for prediction of plant water status  
An apparatus and system for monitoring plant leaves to determine plant water needs and an automated variable-rate irrigation management system which can implement precision irrigation by taking...
US20160182102 CHANNELIZED ACTIVE NOISE ELIMINATION (CANE) FOR BIT STREAM RF TRANSMITTERS  
A band pass filter is implemented utilizing Channelized Active Noise Elimination (CANE) in combining Finite Impulse Response (FIR) filtering into a radio frequency (RF) transmitter, or...
US20160181506 PIEZOELECTRIC NANOPARTICLE-POLYMER COMPOSITE STRUCTURE  
Methods, systems, and devices are disclosed for implementing a stretchable nanoparticle-polymer composite foams that exhibit piezoelectric properties. In one aspect, a nanoparticle-polymer...
US20160181407 METHOD TO FABRICATE QUANTUM DOT FIELD-EFFECT TRANSISTORS WITHOUT BIAS-STRESS EFFECT  
Disclosed herein are embodiments of a method to form quantum dot field-effect transistors (QD FETs) having little to no bias-stress effect. Bias-stress effect can be reduced or eliminated through,...
US20160179751 VIARIABLE STRUCTURE REGRESSION  
Embodiments of a computer implemented method of generating a variable structure regression model. The method includes receiving data input including historical data, an output variable, a...
US20160179599 DATA PROCESSING FRAMEWORK FOR DATA CLEANSING  
A computer-implemented method for reconstructing data includes receiving a selection of one or more input data streams at a data processing framework. The method can include determining existence...
US20160179008 DNA DOUBLE-WRITE/DOUBLE BINDING IDENTITY  
This disclosure relates to DNA double-write/double binding identity, and the design and use of DNA double-write materials and methods in processes and systems for macro, micro, and...
US20160178879 SYSTEM AND METHOD FOR SOLAR ENERGY CAPTURE AND RELATED METHOD OF MANUFACTURING  
A system and method of capturing solar energy, and related method of manufacturing, are disclosed. In at least one embodiment, the system includes a first lens array having a plurality of lenses,...
US20160178645 DIAGNOSTIC AND MONITORING SYSTEM FOR HUNTINGTON'S DISEASE  
The invention provides assays that identify Huntington's disease and monitor the progression and severity of conditions associated with variant Huntingtin protein (Httn). In particular, the...
US20160178584 METHODS FOR DIAGNOSING AND ASSESSING KIDNEY DISEASE  
The technology relates in part to methods for identifying the presence of kidney disease, determining the level of kidney disease, or the progression of kidney disease, in a subject that has or...
US20160177398 DNA Methylation Biomarkers for Bladder Cancer  
A method for the prediction, prognosis and/or diagnosis of bladder cancer or bladder cancer recurrence in a subject, the method includes: providing a test sample from the subject; measuring DNA...
US20160177375 METHODS AND SYSTEMS FOR DETECTING BIOLOGICAL COMPONENTS  
Methods for the detection of components from biological samples are provided. In certain aspects, the methods may be used to detect and/or quantify specific components in a biological sample, such...