Patents and Patent Applications from University of California System


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US20170337466 Deep Learning Neural Network Classifier Using Non-volatile Memory Array  
An artificial neural network device that utilizes one or more non-volatile memory arrays as the synapses. The synapses are configured to receive inputs and to generate therefrom outputs. Neurons...
US20170336486 MRI RECEIVER COIL PROVIDING AN ENHANCED SIGNAL-TO-NOISE RATIO  
A Magnetic Resonance Imaging (MRI) receiver includes a receiver coil on a substrate. The receiver coil includes one or more capacitors. The construction of the capacitors allows for the use of...
US20170335397 METHOD AND DEVICE FOR DIAGNOSING ORGAN INJURY  
The present disclosure relates to methods of collecting exosomes and microvesicles (EMV) from urine and isolating corresponding mRNA in order to diagnose and treat acute kidney injury (AKI). In...
US20170335374 METHODS AND COMPOSITIONS FOR IDENTIFICATION OF SOURCE OF MICROBIAL CONTAMINATION IN A SAMPLE  
Herein are described 1058 different bacterial taxa that were unique to either human, grazing mammal, or bird fecal wastes. These identified taxa can serve as specific identifier taxa for these...
US20170335012 Antibodies Specific for Urokinase-Type Plasminogen Activator and Methods of Use Thereof  
The present disclosure relates to antibodies specific for urokinase-type plasminogen activator (uPA). According to certain embodiments, the anti-uPA antibody specifically binds to the active form...
US20170334981 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR  
Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging...
US20170334823 METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS USING AMINE CATALYSTS  
Provided herein are methods for producing ketone(s) from the condensation of methyl ketone(s) and alcohol(s) in the presence of an amine catalyst and a metal catalyst. Such amine catalysts may be...
US20170334747 SYSTEM AND METHOD FOR FLEXIBLE LOW-ENERGY MEMBRANE-BASED LIQUID PURIFICATION  
A membrane process unit (MPU) is configured to receive a feed stream, subject the feed stream to membrane purification to generate a product stream and a concentrate stream, and subject the...
US20170333571 Targeted Delivery Platform for Delivery of Therapeutics  
The present disclosure provides a targeted delivery platform for delivery of a therapeutic molecule to a target cell. The targeted delivery platform includes a complex that includes the...
US20170333552 COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING  
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon...
US20170333528 METHODS AND COMPOSITIONS FOR MODULATING MYOFIBROBLAST ACTIVITIES  
The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof
US20170333484 METHODS OF TREATING ISCHEMIC SPASTICITY  
The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an...
US20170333468 MIR-214 AS A DIAGNOSTIC AND PROGNOSTIC BIOMARKER SPECIFIC FOR ULCERATIVE COLITIS AND A MIR-214 INHIBITOR FOR TREATMENT OF SAME  
The invention provides a method for detection and monitoring of ulcerative colitis (UC) or UC-related dysplasia in a subject that comprises assaying a specimen from the subject for miR-214, PTEN,...
US20170333450 COMPOSITIONS AND METHODS FOR TREATING HIV-ASSOCIATED COGNITIVE DYSFUNCTION  
The present invention provides methods comprising treating and/or preventing cognitive dysfunction in subjects infected with HIV by administering an antioxidant inflammation modulator (AIM). The...
US20170333427 MULTI-DRUG THERAPIES FOR TUBERCULOSIS TREATMENT  
The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
US20170333373 Glutarate Compounds for Treating Ischemia-Reperfusion Injuries  
Disclosed herein are methods of preventing, inhibiting, reducing, or treating ischemia and reperfusion injury to tissues with glutarate compounds such as α-ketoglutarate.
US20170333360 SPRAY DRY METHOD FOR ENCAPSULATION OF BIOLOGICAL MOIETIES AND CHEMICALS IN POLYMERS CROSS-LINKED BY MULTIVALENT IONS FOR CONTROLLED RELEASE APPLICATIONS  
Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A...
US20170332917 NON-INTRUSIVE PORTABLE SLEEP APNEA ASSESSMENT SYSTEM  
A method of sleep apnea diagnosis includes providing interrogatories at a user interface; receiving responses to the interrogatories at the user interface; receiving blood pressure measurement...
US20170332910 MODIFIED PARAMAGNETIC NANOPARTICLES FOR TARGETED DELIVERY OF THERAPEUTICS AND METHODS THEREOF  
Described herein is a method of inducing vascular inflammation using modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The...
9825321 Self-biased and sustainable microbial electrohydrogenesis device  
A hybrid photoelectrochemical and microbial fuel cell device is provided that includes a single-chamber photoelectrochemical device having an n-type TiO2 photoanode and a Pt counter electrode in...
9824889 CVD silicon monolayer formation method and gate oxide ALD formation on III-V materials  
Methods for depositing silicon include cycling dosing between 1 and 100 cycles of one or more first chlorosilane precursors on a III-V surface at a temperature between 300° C. and 500° C. to form...
9824789 Method for producing nanowire-polymer composite electrodes  
A method for producing flexible, nanoparticle-polymer composite electrodes is described. Conductive nanoparticles, preferably metal nanowires or nanotubes, are deposited on a smooth surface of a...
9824181 Bambam: parallel comparative analysis of high-throughput sequencing data  
The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder....
9823457 Multiplane optical microscope  
This disclosure provides systems, methods, and apparatus related to optical microscopy. In one aspect, an apparatus includes a sample holder, a first objective lens, a plurality of optical...
9823254 Reversible chemoenzymatic labeling of native and fusion carrier protein motifs  
Provided herein, inter alia, are methods and compositions for removing a phosphopantethiene analog moiety from an ACP-phosphopantetheine conjugate thereby providing Apo-ACP proteins.
9823247 Methods and devices for integrating analyte extraction, concentration and detection  
Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a...
9822403 Chip-based droplet sorting  
A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or...
9822373 Mutant cells for protein secretion and lignocellulose degradation  
The present disclosure provides mutant cells for the secretion of proteins and for the degradation of lignocellulosic biomass. Methods for the use of these cells are also provided. Specifically,...
9822309 High carbon concentration biomass and biosolids slurry preparation using a hydro-thermal pretreatment  
Provided is a process where the biomass and bisolids are hydrothermally treated under a reductive gas. Using this process a high carbon content pumpable mixture of biomass and biosolid slurry is...
9822068 Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments  
Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
9821012 Chimeric antigen receptor and methods of use thereof  
The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure...
9820955 GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes  
In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the...
9820692 Wearable electrochemical sensors  
Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor...
9820653 Methods, systems, and devices for imaging microscopic tumors  
An imager for in vivo viewing of diseased tissue by way of fluorescently conjugated molecules. A generally planar imaging surface with a microlens array. The imager may be modular, such that a...
US20170331168 ULTRA-WIDE BAND CIRCULATORS WITH SEQUENTIALLY-SWITCHED DELAY LINE (SSDL)  
A passive circulator utilizing sequentially-switched delay lines (SSDL) in which delay line sections are sequentially turned on and off to achieve non-reciprocity to provide rejection/separations...
US20170331023 THERMOELECTRIC MATERIALS BASED ON TETRAHEDRITE STRUCTURE FOR THERMOELECTRIC DEVICES  
Thermoelectric materials based on tetrahedrite structures for thermoelectric devices and methods for producing thermoelectric materials and devices are disclosed.
US20170329575 FINE-GRAINED ANALOG MEMORY DEVICE BASED ON CHARGE-TRAPPING IN HIGH-K GATE DIELECTRICS OF TRANSISTORS  
A fine-grained analog memory device includes: 1) a charge-trapping transistor including a gate and a high-k gate dielectric; and 2) a pulse generator connected to the gate and configured to apply...
US20170328889 SYSTEMS AND METHODS OF DISEASE MODELING USING STATIC AND TIME-DEPENDENT HYDROGELS  
Provided are methods and devices for the selection and regulation of the mechanical properties of substrates or tissue microenvironments as a technique to model disease progression in tissues....
US20170328194 AUTOENCODER-DERIVED FEATURES AS INPUTS TO CLASSIFICATION ALGORITHMS FOR PREDICTING FAILURES  
The invention relates to using autoencoder-derived features for predicting well failures (e.g., rod pump failures) using a machine learning classifier (e.g., a Support Vector Machine (SVMs))....
US20170327969 PLANAR NONPOLAR GROUP III-NITRIDE FILMS GROWN ON MISCUT SUBSTRATES  
A nonpolar III-nitride film grown on a miscut angle of a substrate. The miscut angle towards the <000-1> direction is 0.75° or greater miscut and less than 27° miscut towards the <000-1>...
US20170327633 COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS  
Provided herein are compositions and methods of making high density nucleic acid polymers.
US20170327448 METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS USING AMINE CATALYSTS  
Provided herein are methods for producing α,β-unsaturated ketones from the condensation of methyl ketones in the presence of an amine catalyst. Such amine catalysts may be supported, for example,...
US20170327389 METHODS OF MAKING METAL-OXIDES AND USES THEREOF FOR WATER TREATMENT AND ENERGY APPLICATIONS  
The disclosure provides relates to compositions and methods for water treatment. It also addresses a method for synthesizing TiO2 (and other metal oxides) with or without dopants. This method...
US20170326544 Composite Separators For Blood Collection Tubes  
Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein. In some aspects, the separator...
US20170326164 BOVINE MILK OLIGOSACCHARIDES  
Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
US20170326114 COGNITIVE FUNCTION  
Provided herein, inter alia, are compounds useful in improving cognitive function, memory and learning in both healthy and diseased subjects.
US20170326093 TARGETING K-RAS-MEDIATED SIGNALING PATHWAYS AND MALIGNANCY BY PROSTRATIN  
The present invention provides method of treating a K-Ras-expressing cancer in a subject comprising administering to the subject a therapeutic amount of prostratin or a prostratin analog, or a...
US20170325724 NON-INVASIVE AND WEARABLE CHEMICAL SENSORS AND BIOSENSORS  
A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly...
US20170325709 METHOD FOR IMPROVED DYNAMIC CONTRAST ENHANCED IMAGING USING TRACER-KINETIC MODELS AS CONSTRAINTS  
Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of DCE-MRI data. The method is flexible in handling any TK model, does not rely on tuning of...
US20170325705 SYSTEM FOR MOTOR REHABILITATION OF A PARETIC LIMB IN STROKE PATIENTS  
A system or method for motor rehabilitation of a paretic limb including: a first plurality of sensors for registering brain neurosignals;a body-actuator;a hybrid brain machine interface for...