Patents and Patent Applications from University of California System


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9328140 Modified mini-hepcidin peptides and methods of using thereof  
Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.
9328129 Peptidomimetic inhibitors of PSMA  
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2)...
9328024 Application of high toughness, low viscosity nano-molecular resin for reinforcing pothole patching materials in asphalt and concrete base pavement  
Described herein are methods of improving the durability of concrete by the infusion of the concrete with a low-viscosity oligomeric solution, and subsequent curing of the oligomeric solution to...
9327036 DNA-cell conjugates  
The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The...
9327016 Enzymes and methods for cleaving N-glycans from glycoproteins  
Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the...
9326995 Oxides for wound healing and body repair  
The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride,...
US20160118099 MAGNONIC HOLOGRAPHIC MEMORY AND METHODS  
An electronic device using an array of magnetic wave guides is shown. In one example a memory device is shown that utilizes spin waves and a magnet storage element that interacts with the spin...
US20160117541 MUT FINGERPRINT ID SYSTEM  
MEMS ultrasound fingerprint ID systems are provided. Aspects of the systems include the capability of detecting both epidermis and dermis fingerprint patterns in three dimensions. Also provided...
US20160116394 Ferrofluid droplets as in situ mechanical actuators and rheometers in soft materials and biological matter  
Presented herein are methods of using ferrofluid droplets as mechanical actuators that work across length scales of nanometers to millimeters. These novel actuators and methods of using them can...
US20160116357 DROPLET-BASED CAPACITIVE PRESSURE SENSOR  
A pressure sensing apparatus which utilizes an electrolytic droplet retained between a first and second sensing electrode within a housing. Contact between the electrolyte droplet and the...
US20160115549 Diagnosing and Monitoring CNS Malignancies Using MicroRNA  
The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
US20160115500 MODIFIED PYR/PYL RECEPTORS ACTIVATED BY LIGANDS  
Modified PYR/PYL receptors activated by orthogonal ligands are provided.
US20160115436 DIGITAL MICROFLUIDIC PLATFORM FOR CREATING, MAINTAINING AND ANALYZING 3-DIMENSIONAL CELL SPHEROIDS  
The invention provides a microfluidic system for forming and/or analyzing multi-cellular spheroids in a hanging drop cell culture. Embodiments of the invention include microfluidic (DμF) systems...
US20160115242 ANTI-CSPG4 FUSIONS WITH INTERFERON FOR THE TREATMENT OF MALIGNANCY  
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that...
US20160115239 CD138-TARGETED INTERFERON DEMONSTRATES POTENT APOPTOTIC AND ANTI-TUMOR ACTIVITIES  
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that...
US20160115220 PROTEOLYTIC RELEASE OF CELL SURFACE ANTIGENS FOR PHAGE BIOPANNING  
The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes...
US20160115211 COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS  
The invention provides pharmaceutical compounds and formulations comprising nucleic acids and polypeptides for regulating (including upregulating or inhibiting) the expression of ApoA-1 Binding...
US20160115143 METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS  
The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to produce the fuels, gasoline additives,...
US20160114322 PARALLELIZED SAMPLE HANDLING  
Provided herein are methods, compositions, and devices for the parallel handling of samples, such as cells or other biological samples. The methods, compositions, and devices are suited for...
US20160114189 SYSTEM AND METHOD FOR DOSE VERIFICATION AND GAMMA RAY IMAGING IN ION BEAM THERAPY  
This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive...
US20160113969 Ameliorating Nervous Systems Disorders  
The present disclosure provides methods for the treatment of a mammal having a neurological condition, disease, or injury. The methods involve increasing the number of functional GABAergic...
US20160113941 METHODS AND SYSTEMS OF TREATING WOUNDS  
The invention generally relates to methods for treating and/or reducing the severity of a wound in a subject. Provided are wound therapies combining low level light therapy (LLLT) and a nitric...
US20160113887 HALOGENATED ETHER COMPOUNDS AND METHODS OF INDUCING ANESTHESIA  
A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of...
US20160113587 ARTIFACT REMOVAL TECHNIQUES WITH SIGNAL RECONSTRUCTION  
Methods, systems, and devices are disclosed for removing non-stationary and/or non-stereotypical artifact components from multi-channel signals. In one aspect, a method for processing a signal...
9325884 Cellscope apparatus and methods for imaging  
An improved system and methods for enhancing the imaging of cameras included with wireless mobile devices, such as cellular phone or tablets. The imaging system includes a releasable optical...
9325333 Fast frequency estimator  
In one aspect, the invention provides a method implemented by an analog hardware circuit for fast frequency estimation. The analog circuit may be implemented a main oscillator circuit block [100],...
9324985 Block copolymer battery separator  
The invention herein described is the use of a block copolymer/homopolymer blend for creating nanoporous materials for transport applications. Specifically, this is demonstrated by using the block...
9324403 Voltage-controlled magnetic anisotropy (VCMA) switch and magneto-electric memory (MERAM)  
Voltage controlled magnetic tunnel junctions and memory devices are described which provide efficient high speed switching of non-volatile magnetic devices at high cell densities. Implementations...
9323397 In-air ultrasonic rangefinding and angle estimation  
An apparatus for determining location of a moveable object in relation to an input device includes an array of one or more piezoelectric micromachined ultrasonic transducer (pMUT) elements and a...
9322042 Thermostable cellulases, and mutants thereof, capable of hydrolyzing cellulose in ionic liquid  
The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition...
9322010 Fusion molecule based on novel TAA variant  
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines...
9321990 Systems and methods for identifying and disrupting cellular organelles  
This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous...
9321866 Polymer monoliths for solvent exchange in continuous flow microfluidic device  
The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow...
9321813 Methods and compositions for cytomegalovirus IL-10 protein  
The present invention provides methods and compositions for treating and/or preventing a cytomegalovirus infection in a subject, comprising administering to the subject an effective amount of a...
9321811 Further novel anti-parasitic compounds  
A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease.
9321772 Substituted pyrazolo[3,4-D]pyrimidines and uses thereof  
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
9321743 Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase  
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA,...
9320736 Zinc chelating agents for depleting XIAP and sensitizing tumor cells to apoptosis  
The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for...
US20160111747 Self-biased and Sustainable Microbial Electrohydrogenesis Device  
A hybrid photoelectrochemical and microbial fuel cell device is provided that includes a single-chamber photoelectrochemical device having an n-type TiO2 photoanode and a Pt counter electrode in...
US20160111721 VOLTAGE-RESPONSIVE COATING FOR LITHIUM-SULFUR BATTERY  
A sulfur-containing electrode with a surface layer comprising voltage responsive material. The electrode is used in a lithium-sulfur or silicon-sulfur battery.
US20160111619 HIGH PERFORMANCE HIGH TEMPERATURE THERMOELECTRIC COMPOSITES WITH METALLIC INCLUSIONS  
The present invention provides a composite thermoelectric material. The composite thermoelectric material can include a semiconductor material comprising a rare earth metal. The atomic percent of...
US20160111072 MULTIFERROIC TRANSDUCER FOR AUDIO APPLICATIONS  
A multiferroic transducer for an electrical stringed-instrument pickup comprising an upper layer and lower layer of magnetostrictive material and a middle layer of piezoelectric or ferroelectric...
US20160110911 FIBER TRACTOGRAPHY USING ENTROPY SPECTRUM PATHWAYS  
A method for fiber tractography processes multi-shell diffusion weighted MRI data to identify fiber tracts by calculating intravoxel diffusion characteristics from the MRI data. A transition...
US20160109726 CONTACT LENS WITH METERED LIQUID SYSTEM  
A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are...
US20160109454 DISEASE-ASSOCIATED ANTIGENS AND METHODS OF USE THEREOF  
The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides...
US20160109258 CONTINUOUS MODE REVERSAL FOR REJECTING DRIFT IN GYROSCOPES  
A vibratory gyroscope system is described which utilizes a mechanical resonator having a first mode of vibration and an associated first natural frequency, and a second mode of vibration having an...
US20160108883 CARPET OF WAVE ENERGY CONVERSION (CWEC)  
A carpet of wave energy conversion (CWEC) device mechanically couples an absorber carpet to one or more energy converters, thereby allowing for wave energy extraction from passing waves. The...
US20160108364 PLURIPOTENT HUMAN ADIPOSE ADULT STEM CELLS: ISOLATION, CHARACTERIZATION AND CLINICAL IMPLICATIONS  
Methods for the efficient isolation and use of pluripotent adipose-derived stem cells (PASCs) are provided. In certain embodiments the methods involve providing an adipose tissue sample from which...
US20160108044 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND CARDIOMYOPATHY  
Disclosed herein inter alia are compositions and methods useful in the treatment neurodegenerative diseases and cardiomyopathy, and for modulating the activity of PINK1.
US20160108007 SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS  
The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.