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Patents and Patent Applications from University of California System


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9072792 Peptides whose uptake by cells is controllable  
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A...
9072732 Indication for use of niacin (nicotinic acid) for treatment and reversal of fatty liver disease  
Niacin prevents and/or reverses the development of experimental hepatic steatosis, deposition of triglycerides in liver and serum of individuals, deposition of total cholesterol in liver and serum...
9072709 Enhancement of bone morphogenic protein (BMP) retention with BMP binding peptide (BBP)  
The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates...
US20150187443 SYSTEMS AND METHODS FOR FORMING AND MAINTAINING A HIGH PERFORMANCE FRC  
Systems and methods that facilitate the formation and maintenance of new High Performance Field Reversed Configurations (FRCs). An FRC system for the High Performance FRC (HPF) includes a central...
US20150185486 HOLOGRAPHIC IMAGING ELEMENT OPERABLE TO GENERATE MULTIPLE DIFFERENT IMAGES OF AN OBJECT  
This disclosure provides systems, methods, and apparatus related to imaging elements. In one aspect, a system includes an electromagnetic radiation source, a detector, and an imaging element. The...
US20150185239 OXIDATIVE BIOMARKERS IN PREDICTING RISK OF STROKE, TRANSIENT ISCHEMIC ATTACK (TIA) AND PERIPHERAL ARTERIAL DISEASE (PAD)  
Provided herein are compositions and methods for examining the progression, regression or risk of individuals for having a stroke, transient ischemic attack or peripheral artery disease.
US20150184163 DIAGNOSTIC AND SCREENING METHODS FOR ATOPIC DERMATITIS  
The present disclosure provides methods for identifying agents that are candidate agents for treating atopic dermatitis. The present disclosure provides methods for diagnosing atopic dermatitis....
US20150184133 Modified bacterium useful for producing an organic molecule  
The present invention provides for a genetically modified host cell or bacterium capable of producing an organic molecule, wherein the bacterium is capable of using hydrogen sulfide as an electron...
US20150184125 MOLECULES WITH EFFECTS ON CELLULAR DEVELOPMENT AND FUNCTION  
This invention relates to methods to stabilize and/or improve the function of parenchymal cells. Also provided are systems of co-cultures of hepatocyte-stabilizing non-parenchymal cells used in...
US20150182539 PREGNANCY HORMONE COMBINATION FOR TREATMENT OF AUTOIMMUNE DISEASES  
The present invention relates to pregnancy hormone combinations and methods of treatment for autoimmune diseases having at least two hormonal components, a pregnancy hormone (such as estriol), and...
US20150182255 Transseptal Access Device and Methods  
The present invention relates to systems and methods for accessing the left heart of a subject. For example, the invention includes a percutaneous inter-ventricular transseptal technique for...
9071204 Digital polar and ZVS contour based hybrid power amplifier  
A power amplifier (PA) which improves dynamic range of previous ZVS contour-based power amplifier architectures is presented. The inventive circuit combines ZVS contour-based power amplification...
9069031 Piezoelectrically actuated magnetic-field sensor  
A magnetic-field sensor that provides an output signal in response to an external magnetic field is described. This magnetic-field sensor includes a pair of cantilevers separated by a horizontal...
9068972 GFP mutagenesis amplification: use of a fluorescence-antibiotic resistance fusion dual reporter construct to provide quantitative and highly sensitive detection of mutations  
A reversion mutation assay that is unique in providing a quantitative readout for mutagenesis. This assay is based on the creation of a functional GFP-β-lactamase fusion protein as a reporter...
9068280 Droplet bilayer formation using throughput liquid handling techniques  
The invention relates to methods and devices for forming and measuring lipid bilayers, for example, by joining lipid monolayers that self-assemble at the interface of aqueous and organic phases...
9067064 Optimization process for volumetric modulated arc therapy  
Systems, techniques, and processes are disclosed for implementing aperture-based optimization techniques. In one aspect, a method performed by an aperture-based radiation treatment system includes...
9066900 Interferon-β production modulating listeria strains and methods for using same  
Mutant Listeria bacteria that modulate interferon-B production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR...
9066855 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders  
Disclosed herein are thermoreverisble gel compositions containing a multiparticulate glutamate receptor antagonist, and methods for the treatment of otic diseases or conditions through...
US20150177560 ELECTRONIC DISPLAYS USING OPTICALLY PUMPED LUMINESCENT SEMICONDUCTOR NANOCRYSTALS  
A multicolor electronic display is based on an array of luminescent semiconductor nanocrystals. Nanocrystals which emit tight of different colors are grouped into pixels. The nanocrystals are...
US20150177458 BONDING OF HETEROGENEOUS MATERIAL GROWN ON SILICON TO A SILICON PHOTONIC CIRCUIT  
A method of fabricating a heterogeneous semiconductor wafer includes depositing a III-V type semiconductor epitaxial layer on a first wafer having a semiconductor substrate. The first wafer is...
US20150177262 AMYLOID BINDING AGENTS  
There are provided compounds and methods for the detection of amyloids and treatment of diseases related to amyloids including Alzheimer's disease and other related amyloid-based neurodegenerative...
US20150176005 MODULATION OF ENHANCER RNA MEDIATED GENE EXPRESSION  
Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many...
US20150175993 NOVEL SYNZYMES  
Novel synthetic catalytic structures or “synzymes,” e.g., synthetic polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic some of the...
US20150175965 NOVEL METHODS TO REGENERATE HUMAN LIMBAL STEM CELLS  
The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which...
US20150175964 Methods and Compositions for the Rapid Production of Retinal Pigmented Epithelial Cells from Pluripotent Cells  
The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell...
US20150175962 GENERATING HEPATOCYTES  
Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and...
US20150174197 Peptoids Useful for the Mineralization of Apatite  
The present invention provides for a bio-mimetic polymer capable of catalyzing or mineralizing calcium ion and phosphate ions into an apatite.
US20150174076 MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS  
Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active...
US20150173929 CONTROLLABLE PASSIVE ARTIFICIAL KNEE  
An exoskeleton (100) adapted to be coupled to a lower extremity of a person includes a thigh link (102), a shank link (104) and a knee joint (106) allowing flexion and extension between the thigh...
US20150173824 TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION  
A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the...
9065093 Controlled porosity in electrodes  
Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries,...
9065002 Shallow-trench-isolation (STI)-bounded single-photon avalanche photodetectors  
Techniques and apparatus for using single photon avalanche diode (SPAD) devices in various applications.
9064678 Vacuum photosensor device with electron lensing  
A scalable vacuum photosensor configured to simplify mass production with a housing having an evacuated first side at an ultrahigh vacuum and a second side which does not require high vacuum. The...
9064312 Augmented reality using projector-camera enabled devices  
An augmented reality scene may be registered onto an arbitrary surface. A camera may capture an image of the arbitrary surface. The camera may analyze the surface geometry of the arbitrary...
9063363 Electronic displays using optically pumped luminescent semiconductor nanocrystals  
A multicolor electronic display is based on an array of luminescent semiconductor nanocrystals. Nanocrystals which emit light of different colors are grouped into pixels. The nanocrystals are...
9063352 Telescopic contact lens  
Techniques, systems and apparatus are described for implementing a telescopic contact lens. In one aspect, a telescopic contact lens includes an inner lens including optical apertures and aspheric...
9063204 Increasing the perfusion signal to noise ratio (SNR) in velocity selective arterial spin labeling (VSASL) in magnetic resonance imaging  
Techniques, systems computer program products are disclosed increasing tagging efficiency in velocity selective arterial spin labeling using multiple velocity selective saturation modules. In one...
9063133 Methods and devices for biomolecular arrays  
Provided herein are methods of assembling high density biomolecular arrays. The disclosed methods and devices combine a photolithographic step with the assembly of particles conjugated to...
9063125 Compositions comprising cells expressing cold- and menthol-sensitive receptor (CMR1) polypeptides  
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
9063124 Method for identifying compounds that modulate a T2R taste receptor  
The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic...
9062985 Efficient K-nearest neighbor search in time-dependent spatial networks  
The class of k Nearest Neighbor (k NN) queries in spatial networks has been studied in the literature. Existing approaches for k NN search in spatial networks assume that the weight of each edge...
9062353 Electrically conductive polymer electrodes with incorporated viruses  
Grafting M13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The...
9062323 Identification and use of KRP mutants in wheat  
The invention provides a wheat cell, part, tissue culture or whole plant comprising at least one disrupted KRP gene of the present invention. The present invention also provides methods of...
9062107 Methods for enhancing bacterial cell display of proteins and peptides  
Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display...
9062073 Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor  
Provided herein are benzopyrimido-pyrrolo-oxazine-dione (BPO) compounds and pyrimido-pyrrolo-quinoxalinedione (PPQ) compounds, and compositions comprising these compounds, that inhibit cystic...
9061912 Methods of fabrication of graphene nanoribbons  
Methods of fabricating graphene nanoribbons include depositing a catalyst layer on a substrate. A masking layer is deposited on the catalyst layer. The masking layer and the catalyst layer are...
9061071 Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels  
Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety,...
9061048 Cyclic di-AMP induction of type I interferon  
Methods of modulating type-I interferon production in a cell are provided. Aspects of the methods include modulating cytosolic cyclic di-adenosine monophosphate (c-di-AMP) activity in the cell in...
9060714 System for detection of body motion  
Methods for classifying aggregated data in a distributed sensor system are provided and illustrated with a wearable motion sensor network. The classification is operated in a distributed fashion...
US20150171326 SYSTEMS AND METHODS FOR INTEGRATING A SINGLE DNA MOLECULE INTO A MOLECULAR ELECTRONIC DEVICE  
The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“SWNTs”) and integrating a single nucleic acid...