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Patents and Patent Applications from University of California System


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US20140298543 PLANT CO2 SENSORS, NUCLEIC ACIDS ENCODING THEM, AND METHODS FOR MAKING AND USING THEM  
The invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling CO2 sensor genes. The invention provides...
US20140298539 SPATIALLY MODIFIED GENE EXPRESSION IN PLANTS  
The invention provides methods of engineering plants having lignin deposition or xylan deposition that is substantially localized to the vessels of xylem tissue in the plant. The invention also...
US20140298507 Synthetic Clonal Reproduction Through Seeds  
Clonal embryos or seeds produced by conversion of apomeiotic gametes into clonal embryos or seeds. Clonal embryos or seeds are produced by crossing a MiMe plant, as either a female or male, with an...
US20140298049 DIGITAL SIGNAL TRANSITION COUNTERS FOR DIGITAL INTEGRATED CIRCUITS  
A digital integrated circuit may include a digital data processing circuit having multiple signal lines that each go through signal transitions during operation of the digital data processing...
US20140296693 PRODUCTS OF MANUFACTURE AND METHODS USING OPTICAL COHERENCE TOMOGRAPHY TO DETECT SEIZURES, PRE-SEIZURE STATES AND CEREBRAL EDEMAS  
In alternative embodiments, the invention provides compositions, products of manufacture and medical devices, and methods, using optical coherence tomography to monitor for a physiological event...
US20140296531 Novel semi-synthetic small molecules for the treatment parasitic disease  
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping...
US20140296215 Cyanoquinoline Compounds Having Activity in Correcting Mutant-Cftr Processing and Increasing Ion Transport and Uses Thereof  
The present disclosure provides pharmaceutical compositions, pharmaceutical preparations and methods for increasing activity of a mutant cystic fibrosis transmembrane conductance regulator protein...
US20140295549 METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS BY STIMULATING ER STRESS  
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA...
US20140295517 Host Cells and Constructs Useful for Producing Pinene  
The present invention provides for a modified host cell comprising a heterologous pinene synthase (PS), or enzymatically active fragment or variant thereof, and optionally a geranyl pyrophosphate...
US20140295498 Targeted Rolling Circle Amplification  
Methods for amplifying a desired target region of a nucleic acid through rolling circle amplification with a strand-displacing polymerase are provided. Concatameric hairpin products are resolved...
US20140295485 MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY  
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or...
US20140295484 MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY  
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or...
US20140295448 SUPPRESSION OF TLA2-CpFTSY GENE EXPRESSION FOR IMPROVED SOLAR ENERGY CONVERSION EFFICIENCY AND PHOTOSYNTHETIC PRODUCTIVITY IN ALGAE  
The invention provides method and compositions to minimize the chlorophyll antenna size of photosynthesis by decreasing TLA2 gene expression, thereby improving solar conversion efficiencies and...
US20140295412 METHODS AND SYSTEMS FOR DIRECT SEQUENCING OF SINGLE DNA MOLECULES  
The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine,...
US20140295269 CONFORMAL COATING OF NANO-POROUS MATERIAL WITH GROUP IV SEMICONDUCTOR USING NANOPARTICLE INK  
A nanostructured composite material includes a substrate, a porous layer including a highly structured material, and a coating including nanoparticles. A method for forming the nanostructured...
US20140294942 ANTIVIRAL PEPTIDES EFFECTIVE AGAINST HEPATITIS C VIRUS  
In certain embodiments this invention provides novel antiviral peptide(s) that are effective against positive sense RNA viruses that have an internal ribosome entry site (IRES). The peptide(s) can...
US20140294930 STREPTOCOCCAL GlcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM  
In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A Streptococcus (GAS), Group C...
US20140294782 Reprogramming of Cellular Adhesion  
Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds,...
US20140294771 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20140294709 ALKYLAMINE FUNCTIONALIZED METAL-ORGANIC FRAMEWORKS FOR COMPOSITE GAS SEPARATIONS  
Functionalized metal-organic framework adsorbents with ligands containing basic nitrogen groups such as alkylamines and alkyldiamines appended to the metal centers and method of isolating carbon...
US20140294140 RADIOGRAPHIC PHANTOM APPARATUSES  
There is provided a radiographic phantom for inter alia mimicking specific anatomical parts in a computerized tomography scan. Methods are provided for a variety of purposes including detecting a...
US20140293683 MAGNETO-RESISTIVE EFFECT ELEMENT  
[PURPOSE] According to the invention there is provided a magneto-resistive effect element having a larger magneto-resistive ratio than in the prior art.[SOLUTION MEANS]The magneto-resistive effect...
US20140293028 MULTI VIEW SYNTHESIS METHOD AND DISPLAY DEVICES WITH SPATIAL AND INTER-VIEW CONSISTENCY  
An embodiment of the invention is a method that provides common data and enforces multiple view consistency. In a preferred embodiment, a coordinate alignment matrix is generated after initial...
US20140292517 SYSTEM AND METHODS FOR GENERATING PREDICTIVE COMBINATIONS OF HOSPITAL MONITOR ALARMS  
Systems and methods are disclosed for monitoring data associated with a plurality of physiological characteristics of a patient, comprising: the methods include generating a set of super-alarm...
US20140292420 HIGH-SPEED CMOS RING VOLTAGE CONTROLLED OSCILLATOR WITH LOW SUPPLY SENSITIVITY  
High-speed CMOS ring voltage controlled oscillators with low supply sensitivity have been disclosed. According to one embodiment, a CML ring oscillator comprises a CML negative impedance...
US20140291694 PLANAR NONPOLAR GROUP-III NITRIDE FILMS GROWN ON MISCUT SUBSTRATES  
A nonpolar III-nitride film grown on a miscut angle of a substrate, in order to suppress the surface undulations, is provided. The surface morphology of the film is improved with a miscut angle...
US20140291609 JUNCTIONLESS SEMICONDUCTOR LIGHT EMITTING DEVICES  
A junctionless light emitting device comprises a field emitter cathode, and a light emitting semi-conductor material sandwiched between an ohmic contact (OC) that faces the injected electrons and a...
US20140291296 NANOMATERIALS FABRICATED USING SPARK EROSION AND OTHER PARTICLE FABRICATION PROCESSES  
Methods, systems, and devices are disclosed for fabricating clean, oxidation-free nanoparticles of electrically conducting metals and alloys using spark erosion techniques. In one aspect, a method...
US20140290987 SOLUTION PROCESSED NANOPARTICLE-NANOWIRE COMPOSITE FILM AS A TRANSPARENT CONDUCTOR FOR OPTO-ELECTRONIC DEVICES  
An electro-optic device includes a substructure, a layer of nanowires deposited on the substructure so as to form a network of nanowires having electrically connected junctions at overlapping...
US20140290737 THIN FILM VLS SEMICONDUCTOR GROWTH PROCESS  
A composition comprising a substrate, a polycrystalline III-V semiconductor layer, and an oxide layer disposed above the polycrystalline III-V semiconductor layer is described. A growth method that...
8849581 Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity  
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or...
8847606 Method and system for assessing insulation deterioration in live underground power cables  
A method for assessing insulation deterioration in a live underground power cable may include, in one embodiment, attaching a coupling device to a live underground power cable and using the...
8847592 Techniques for magnetic particle imaging  
A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a...
8847476 Electron injection nanostructured semiconductor material anode electroluminescence method and device  
Embodiments of the invention include methods and devices for producing light by injecting electrons from field emission cathode across a gap into nanostructured semiconductor materials, electrons...
8847313 Transparent electronics based on transfer printed carbon nanotubes on rigid and flexible substrates  
Methods and devices for transparent electronics are disclosed. According to an embodiment, transparent electronics are provided based on transfer printed carbon nanotubes that can be disposed on...
8846932 Small molecules modulator of epigenetic regulation and their therapeutic applications  
Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to...
8846866 Aldehyde tags, uses thereof in site-specific protein modification  
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag...
8846770 Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders  
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an...
8846697 Purine analogs  
The present invention provides purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human...
8846643 Phosphonates with reduced toxicity for treatment of viral infections  
There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are...
8846629 Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma  
A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a...
8846572 Use of 9-beta-D-adenosine to increase crop production  
Described are compositions and methods to increase bud break in order to increase aspects of one or both of plant vegetative and reproductive growth, by use of a natural metabolite. In particular,...
8846066 Methods and related compositions for reduction of fat and skin tightening  
Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically active detergents are disclosed. The...
8845999 Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease  
Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at...
8845554 Method and apparatus for quantitative assessment of neuromotor disorders  
The present invention relates to methods and apparatus for quantitative assessment of neuromotor disorders using sensors and analyzing the data collected from the sensors to determine if a patient...
8844369 Concentration independent modulation of local micromechanics in a fibrin gel  
An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post...
US20140288643 DEVICE TO STORE AND INJECT CORNEAL GRAFT  
Devices and methods for storing and injecting a corneal tissue graft are disclosed herein. In one embodiment, an apparatus includes a tissue container and an adaptor configured to be coupled to the...
US20140288544 IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS  
A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An...
US20140288515 MICROPATTERNED TEXTILE FOR FLUID TRANSPORT  
This invention includes the implementation of several unconventional droplet manipulations on a superhydrophobic-patterned surface microfluidic platform, which may be applied to automated...
US20140288421 GAS VESICLE ULTRASOUND CONTRAST AGENTS AND METHODS OF USING THE SAME  
Provided are ultrasound imaging methods that include administering to a subject a contrast agent that includes a plurality of collapsible gas vesicles, obtaining ultrasound data of a target site of...