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Patents and Patent Applications from University of California System


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8828383 Nanocarriers with multi-photon response elements  
Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to...
8828378 Targeted vectors for cancer immunotherapy  
This invention provides compositions and methods for treating cancer. More specifically this invention is directed to a targeted retroviral vector comprising a cytokine gene that can be...
8828302 Preparation and use of nanowrinkles  
Provided are methods of preparing a textured surface on a thermoplastic material that include treating the material with a plasma and subsequently shrinking the substrate to induce formation of...
8826726 Gas sensor  
A gas sensor is described which incorporates a sensor stack comprising a first film layer of a ferromagnetic material, a spacer layer, and a second film layer of the ferromagnetic material. The...
US20140250553 SENSOR FOR LOW FORCE-NOISE DETECTION IN LIQUIDS  
The embodiments described herein provide a sensor. In an exemplary embodiment, the sensor includes (1) a resonator, (2) a probe attached to the resonator, and (3) an encasement that encases the...
US20140249620 ULTRA-LOW FRACTIONAL AREA COVERAGE FLOW DIVERTER FOR TREATING ANEURYSMS AND VASCULAR DISEASES  
A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an...
US20140249614 THIN FILM VASCULAR STENT AND BIOCOMPATIBLE SURFACE TREATMENT  
A vascular implant, comprising a sheet comprising thin film nickel titanium (NiTi), wherein the sheet has at least one super-hydrophilic surface having a water contact angle of less than...
US20140249444 BURST SUPPRESSION MONITOR FOR INDUCED COMA  
Methods and systems for monitoring subjects, analyzing EEG data, and maintaining subjects at desired sedation states using automatic processing systems to determine a mean burst suppression...
US20140249236 Salivary mRNA Profiling, Biomarkers and Related Methods and Kits of Parts  
A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva...
US20140249193 MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT  
The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
US20140249140 Nerve Agent Antidotes  
The present invention includes compositions that are useful in treating, ameliorating, or preventing nerve agent poisoning. The present invention also includes methods of preventing, treating or...
US20140248711 APPARATUS AND METHOD FOR ELECTRICAL DETECTION OF OLIGONUCLEOTIDES THROUGH PORE BLOCKADES  
Systems and methods for specific nucleic acid (NA) sequence detection that do not rely on polymerase chain reaction (PCR) for target sequence amplification and do not require any special reagents...
US20140248633 LEUKEMIA STEM CELL TARGETING LIGANDS AND METHODS OF USE  
The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection...
US20140248333 COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES  
In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or...
US20140248289 Methods and Compositions for the Treatment of Respiratory Conditions Via NKG2D Inhibition  
Methods and compositions for the treatment of respiratory conditions are provided. Aspects of the subject methods include administering to the subject a composition comprising an inhibitor of...
US20140248278 ANTI-CD22 ANTIGEN BINDING MOLECULES TO TREAT LUNG CANCER AND PROSTATE CANCER  
This invention provides methods for preventing, reducing, delaying or inhibiting the proliferation and/or growth and/or metastasis of lung cancers and prostate cancer that express or overexpress...
US20140248218 ROS-SENSITIVE FLUORESCENT PROBES  
Herein are provided, inter alia, compositions including boronic esters, which in the presence of H2O2, provide for the detection of ROS compounds such as endogenous H2O2 and methods of using the...
US20140248212 NON-IMMUNOGENIC POSITRON EMISSION TOMOGRAPHY REPORTER GENE SYSTEMS  
Embodiments of the invention include a PET/SPECT reporter gene system that uses enhanced non-immunogenic versions of a human mitochondrial thymidine kinase 2 expressed in cytoplasm to...
US20140247115 NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY BIOMETRICS  
Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a...
8825466 Modification of annotated bilingual segment pairs in syntax-based machine translation  
Systems and methods for automatically modifying an annotated bilingual segment pair are provided. An annotated bilingual segment pair (“Pair”) may be modified to generate improved translation rul...
8824707 Acoustic substrate  
A micromachined microphone or speaker embedded within, or positioned on top of, a substrate suitable for carrying microelectronic chips and components. The acoustic element converts sound energy...
8823526 Method of assessing human fall risk using mobile systems  
A method for determining the motive instability of an individual using foot pressure, foot speed and foot direction data collected from sensors on shoes. The sensed data is used to determine the...
8823154 Encapsulation architectures for utilizing flexible barrier films  
An article and method of using spacer layer regions is provided, containing a gas compound, to reduce gas permeation through barrier films overlying a substrate comprising creating a spacer layer...
8822618 Microcapsule and methods of making and using microcapsules  
An embodiment of a microcapsule includes a shell surrounding a space, a liquid within the shell, and a light absorbing material within the liquid. An embodiment of a method of making microcapsules...
8822042 Luminescent cyclometallated iridium(III) complexes having acetylide ligands  
The present invention relates to phosphorescent (triplet-emitting) organometallic materials. The phosphorescent materials of the present invention comprise Ir(III)cyclometallated alkynyl complexes...
8821884 Compositions and methods using MD-2 mutants and chimeric proteins  
The invention provides compositions and methods for the targeted bacteriostatic and antibacterial agents and for treatment of sepsis caused by infectious diseases, such as bacterial and fungal...
8821408 Data mining system for noninvasive intracranial pressure assessment  
Systems and methods are described for noninvasively assessing an intracranial pressure of a patient. Some embodiments include providing a simulation model with a measured arterial blood pressure of...
8820325 Bymixer apparatus and method for fast-response, adjustable measurement of mixed gas fractions in ventilation circuits  
Bymixer devices and methods for sampling or obtaining data from mixed respiratory gases in a ventilation circuit. Respiratory gasses from a plurality of consecutive breaths become mixed within a...
US20140245490 FERTILIZATION AND FRUIT SIZE  
Plants having modulated expression of a HAF or BEE polypeptide and which modulate aspects of plant fertility, such as parthenocarpy, fertilization efficiency, and/or fruit size, are described....
US20140244982 PERFORMING STENCIL COMPUTATIONS  
A method and apparatus for performing stencil computations efficiently are disclosed. In one embodiment, a processor receives an offset, and in response, retrieves a value from a memory via a...
US20140244552 GLOBAL MODEL FOR FAILURE PREDICTION FOR ARTIFICIAL LIFT SYSTEMS  
Methods and systems for predicting failures in an artificial lift system are disclosed. One method includes extracting one or more features from a dataset including time sampled performance of a...
US20140244217 APPARATUS AND METHOD FOR IMPROVED OPTICAL DETECTION OF PARTICLES IN FLUID  
A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at...
US20140243425 CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF  
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual...
US20140243357 SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF  
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
US20140243356 USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT  
The present invention provides methods of identifying an agent that modulates an oncogenic signaling pathway in a biological sample by generating a translational profile of gene translational...
US20140243189 DIRECT ASSEMBLY OF HYDROPHOBIC NANOPARTICLES TO MULTIFUNCTION STRUCTURES  
A process that allows convenient production of multifunctional composite particles by direct self-assembly of hydrophobic nanoparticles on host nanostructures containing high density surface thiol...
US20140242712 FLUORESCENCE DETECTION OF POISON OAK OIL  
The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to...
US20140242649 Hybrid organic-inorganic system for producing biofuels  
The present invention provides for a system for converting CO2 and H2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more...
US20140242598 MULTIPLEX PCR-BASED TESTING OF CUTANEOUS SQUAMOUS CELL CARCINOMA AND PSEUDOEPITHELIOMATOUS HYPERPLASIA AND METHODS FOR DISTINGUISHING THE SAME  
Methods for differentiating squamous cell carcinoma from pseudoepitheliomatous hyperplasia in a biological sample using KRT9 and C15orf48, methods of using differentially expressed genes as...
US20140242590 FLT3 MUTATIONS ASSOCIATED WITH DRUG RESISTANCE IN AML PATIENTS HAVING ACTIVATING MUTATIONS IN FLT3  
The invention provides methods and compositions for identifying acute myeloid leukemia (AML) patients that have an increased likelihood of a relapse following treatment with AC 220.
US20140242123 SACCHARIDE-PEPTIDE HYDROGELS  
The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or...
US20140242031 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The...
US20140241596 Apparatus and Method for Capturing a Vital Vascular Fingerprint  
A method using optical coherence tomography to capture the microvascular network of the superficial layer of the finger skin for the purpose of fingerprint authentication and liveness detection. At...
US20140241366 Comprehensive Multipath Routing for Congestion and Quality-of-Service in Communication Networks  
A packet routing method includes computing, for each source node in the data network and each destination node in the data network, a set of multiple routes providing a full range of performance...
US20140239249 RAPID BIOLOGICAL SYNTHESIS PROCESS TO PRODUCE SEMICONDUCTING CHALCOGENIDE NANOSTRUCTURES FOR TRANSISTOR OR SOLAR CELL APPLICATIONS  
The process disclosed herein produces macroscopic quantities of semiconducting arsenic sulfide nanofibers within one to three days. The process is biotically influenced by the bacteria Shewanella...
US20140238858 DIELECTROPHORESIS AND ELECTRODEPOSITION PROCESS FOR SELECTIVE PARTICLE ENTRAPMENT  
A method of creating a structure on an electrode includes exposing an electrode to a solution containing a polymerizable monomer and particles and applying an AC voltage to the electrode so as to...
US20140238013 VANADIUM DIOXIDE MICROACTUATORS  
This disclosure provides systems, methods, and apparatus related to vanadium dioxide microactuators. In one aspect, a method includes depositing a vanadium dioxide layer on a sacrificial layer...
8817891 Milli-meter-wave-wireless-interconnect (M2W2-interconnect) method for short-range communications with ultra-high data rate capability  
A millimeter wave wireless (M2W2) interconnect is used for transmitting and receiving signals at millimeter-wave frequencies for short-range wireless communication with high data rate capability....
8817629 Method for routing-assisted traffic monitoring  
A method for routing-assisted traffic monitoring includes providing a set of flows, each flow having an associated ingress routing device and an associated egress routing device. A controller...
8816325 Scalable quantum computer architecture with coupled donor-quantum dot qubits  
A quantum bit computing architecture includes a plurality of single spin memory donor atoms embedded in a semiconductor layer, a plurality of quantum dots arranged with the semiconductor layer and...