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Patents and Patent Applications from University of California System


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9045507 Coumarin-based amino acids for use in enzyme activity and substrate specificity assays  
The design, synthesis, and utilization of a novel coumarin-based amino acid and its fluorinated derivatives for use in enzyme activity and substrate specificity assays are described. The synthesis...
9045474 Compounds and compositions for mitigating tissue damage and lethality  
Embodiments of the present invention provide compounds and compositions thereof, which are effective for mitigating tissue damage or lethality induced by an agent, and methods of making and using...
9045401 Methods for treating or ameliorating a melanoma and killing melanoma cells  
The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and...
9045387 Oxidative homo-coupling reactions of aryl boronic acids using a porous copper metal-organic framework as a highly efficient heterogeneous catalyst  
The disclosure provides methods for the use of open metal frameworks to catalyze coupling reactions.
9044611 Systems and methods for selectively migrating cells using electric fields  
Systems and methods are provided for migrating cells implanted or endogenous in tissue. The system may include first and second delivery electrodes configured for insertion in tissue and a direct...
9044514 Lipid-peptide-polymer conjugates and nanoparticles thereof  
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer...
9044018 Mitigation of alternate bearing  
Described are compositions and methods to mitigate alternate bearing of perennial crops by use of a natural metabolite. In particular, the present disclosure provides a natural metabolite in the...
9044007 Device and method for ambient storage of fresh/frozen tissue sections via desiccation  
The present invention discloses a method for storing and preserving previously sectioned, snap-frozen, and desiccated biological tissue samples at ambient conditions. Also disclosed are devices...
US20150150156 METHODS AND COMPOSITIONS FOR REDUCING GENE EXPRESSION IN PLANTS  
The present disclosure relates to recombinant methyltransferases that epigenetically silence gene expression and to methods of using such proteins for reducing the expression of genes in plants.
US20150149495 DATA REDUCTION METHODS, SYSTEMS, AND DEVICES  
Systems, methods, and apparatus are disclosed herein for data pattern detection and data reduction. Devices include an input port configured to receive data values that include a plurality of data...
US20150148801 MICRO-BIPOLAR ENDOSCOPIC ENDONASAL CAUTERY DEVICE  
A bipolar electrosurgical forceps device having a handle at the proximal end and forceps jaws at the distal end is described. These two ends are connected via an elongated tubular section that...
US20150148667 METHOD AND SYSTEM FOR IN VIVO HYDROGEN PEROXIDE DETECTION WITH ULTRASOUND  
A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound...
US20150148649 SYSTEMS AND METHODS FOR OBTAINING RHEOLOGICAL PROPERTIES OF VISCOELASTIC MATERIALS  
Systems and methods are disclosed for obtaining rheological properties of viscoelastic medium, and in particular, in-vivo evaluation of body fluid such as the vitreous. The system includes a...
US20150148549 DISPOSABLE WORLD-TO-CHIP INTERFACE FOR DIGITAL MICROFLUIDICS  
The present disclosure sets forth incorporating microfluidic chips Interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact,...
US20150148387 METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE  
Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to...
US20150148314 SERINIQUINONES, MELANOMA-SPECIFIC ANTICANCER AGENTS  
There are provided, inter alia, derivatives of seriniquinone and methods useful for the treatment of cancer, and in particular treatment of melanoma and prostate cancer.
US20150147810 ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS  
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be...
US20150147283 Methods for limiting development of a skin wound  
The present invention provides methods for limiting development of skin wounds, and also for treatment of one or more of erythemas, blisters, rashes, pruritis, contact dermatitis, psoriasis,...
US20150147281 CARIES RISK TEST FOR PREDICTING AND ASSESSING THE RISK OF DISEASE  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
US20150144558 SLOW DIALYSATE ADAPTOR APPARATUS FOR INTERMITTENT HEMODIALYSIS  
A system and method for providing slow dialysate flow with an intermittent hemodialysis delivery (IHD) system are disclosed. The system includes a dialysate slow-flow fluid pump having an outlet...
US20150144142 Device and Method for Correcting Obstructive Sleep Apnea  
An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is...
US20150144013 Instrumentation to Dry-Deliver SLMP Particles to the Lithium-Ion Electrode  
An embodiment of the invention describes an calendaring apparatus comprising a roller press comprising a first roller and a second roller, a static electricity generator, a motor drive system in...
US20150143823 System and Method for Solar Powered Thermal Management and Transport  
A refrigeration system for vaccine storage and/or transportation includes an inner chassis. One or more vertical lift carriages are positioned in the inner chassis and can house a plurality of...
US20150143784 CROSSFLOW FILTRATION PARTICLE SEPARATOR  
A form of crossflow filtration particle separator which receives a particle laden moving fluid surrounded by a clear moving fluid at a proximal end, and separates the particles into a collection...
9043163 Systems and methods for analyzing building operations sensor data  
Systems and methods are disclosed for analyzing building sensor information and decomposing the information therein to a more manageable and more useful form. Certain embodiments integrate...
9043159 Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity  
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or...
9040626 Nanofibers and morphology shifting micelles  
The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
9040327 Al(x)Ga(1-x)N-cladding-free nonpolar III-nitride based laser diodes and light emitting diodes  
A method for fabricating AlxGa1-xN-cladding-free nonpolar III-nitride based laser diodes or light emitting diodes. Due to the absence of polarization fields in the nonpolar crystal planes, these...
9040326 High light extraction efficiency nitride based light emitting diode by surface roughening  
A III-nitride light emitting diode (LED) and method of fabricating the same, wherein at least one surface of a semipolar or nonpolar plane of a III-nitride layer of the LED is textured, thereby...
9040282 Producing dicarboxylic acids using polyketide synthases  
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention...
9040266 Cell-based systems for production of methyl formate  
Disclosed is a process in which a recombinant organism, such as a yeast, expressing a heterologous S-adenosylmethionine (SAM)-dependent methyl halide transferase (MHT) protein is combined with a...
9039834 Non-polar gallium nitride thin films grown by metalorganic chemical vapor deposition  
Non-polar (11 20) a-plane gallium nitride (GaN) films with planar surfaces are grown on (1 102) r-plane sapphire substrates by employing a low temperature nucleation layer as a buffer layer prior...
9039213 Light concentration apparatus, systems and methods  
An optical device is disclosed including: a non-imaging secondary concentrator having an entry aperture and an exit aperture, and configured to receive light focused by a primary focusing element...
9039171 Aerated contact lens assembly  
A contact lens assembly includes a proximal layer formed from a gas-permeable material, a distal layer with an optical element, an air cavity disposed between the proximal layer and the distal...
US20150142465 PATHWAY RECOGNITION ALGORITHM USING DATA INTEGRATION ON GENOMIC MODELS (PARADIGM)  
A patient sample specific dynamic pathway map is constructed on the basis of measured patient data and a probabilistic pathway model that is based on attributes for pathway elements, wherein some...
US20150142398 METHODS FOR A MULTI-SCALE DESCRIPTION OF THE ELECTRONIC STRUCTURE OF MOLECULAR SYSTEMS AND MATERIALS AND RELATED APPLICATIONS  
A method for simulating a molecular system involving partitioning the system into a plurality of subsystems at the level of one-particle basis functions and applying different mean-field levels of...
US20150142336 PREDICTING THE INFLUENCE OF MINERAL ADDITIONS ON REACTION AND PROPERTY DEVELOPMENT IN CEMENTITIOUS MIXTURES  
A mechanical property of a cementitious mixture is predicted by: (1) receiving user input characterizing a mixture of a cement and a mineral addition, the user input corresponding to at least one...
US20150141950 COMPOSITIONS AND METHODS FOR REDUCING EDEMA  
The invention provides compositions and methods for the treatment and/or reversal of an edema, e.g., including a central nervous system (CNS) edema, e.g., a brain or a spinal edema, edema in a...
US20150141879 Device, System and Method for Reducing Headache Pain  
A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit...
US20150141876 METHOD FOR PROVIDING DIRECTIONAL THERAPY TO SKELETAL JOINTS  
An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or...
US20150141392 SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY  
The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including...
US20150141250 USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION  
Described are compositions and methods to increase bud break in order to increase aspects of one or both of plant vegetative and reproductive growth, by use of a natural metabolite. In particular,...
US20150140663 IN VITRO RECONSTITUTED PLANT VIRUS CAPSIDS FOR DELIVERING RNA GENES TO MAMMALIAN CELLS  
The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (CCMV CP) and a ribonucleic acid, as well as methods for using such compositions. In such...
US20150140644 TREATMENT OF LEAF TISSUE FOR THE RECOVERY OF INTERSTITIAL RECOMBINANT PROTEINS BY THE APPLICATION OF CELL WALL DEGRADING ENZYMES  
The present disclosure relates to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue, and increasing the yield of recovery of an...
US20150140609 Anti-alpha(v)beta(6) Antibodies  
Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Q...
US20150140427 Nanoporous Silicon Network Thin Films as Anodes for Lithium Ion Batteries  
Various embodiments of the invention describe nanoporous silicon (Si) network thin films with controllable porosity and thickness that are fabricated by a robust and scalable electrochemical...
US20150140059 NOVEL OXYSTEROL ANALOGUE, OXY149, INDUCES OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBITS ADIPOGENESIS  
This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable...
US20150140008 USES OF CXCL17, A NOVEL CHEMOKINE MARKER OF HUMAN LUNG AND GASTROINTESTINAL DISEASE  
A method of treating a disease associated with increased levels of chemokine CXCL17. The method includes administering to a subject in need of such treatment a therapeutically effective amount of...
US20150139994 COMPOSITIONS AND METHODS FOR PREVENTING ALLOGENEIC IMMUNE REJECTION  
The present invention provides methods for preventing the allogeneic immune rejection of allogeneic cells, such as cells derived from human Embryonic Stem Cells (hESCs), without suppressing the...
US20150139981 ENZYMATIC MODIFICATION OF ANTI-AQP4 AUTOANTIBODY FOR MODULATING NEUROMYELITIS OPTICA  
Provided herein is a method of treating neuromyelitis optica (NMO) in an animal or human subject comprising administering to the subject a composition comprising a therapeutically effective amount...