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Patents and Patent Applications from University of California System


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US20150216939 METHODS OF TREATING MILD BRAIN INJURY  
The present technology generally is directed to methods for treating mild brain injury and other neurological disorders in a subject. The methods can include administering to the subject an...
US20150216829 Compounds and Methods for Modulating Vascular Injury  
Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators...
US20150216684 DUAL ROTATIONAL STENT APPARATUS AND METHOD FOR ENDOVASCULAR TREATMENT OF ANEURYSMS  
A coaxial stent system is described in which an inner treatment stent is configured to be coaxially positioned inside an outer anchoring stent. The outer anchoring stent is adapted for insertion...
9099641 Systems and methods for implementing magnetoelectric junctions having improved read-write characteristics  
Embodiments of the invention implement MEJs having improved read-write characteristics. In one embodiment, an MEJ includes: ferromagnetic fixed and free layers, a dielectric layer interposed...
9098773 System and method of detecting objects in scene point cloud  
A system and method of detecting one or more objects in a three-dimensional point cloud scene are provided. The method includes receiving a three-dimensional point cloud scene, the...
9098764 Image-based barcode reader  
Barcode decoding bypassing binarization is provided which relies on deformable templates to makes use of all the gray level information of each pixel in the barcode image. Parameterization of the...
9097848 III-V photonic integration on silicon  
Photonic integrated circuits on silicon are disclosed. By bonding a wafer of HI-V material as an active region to silicon and removing the substrate, the lasers, amplifiers, modulators, and other...
9097707 Photoreactive regulator of protein function and methods of use thereof  
The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that...
9097676 Device and methods of detection of airborne agents  
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including...
9096902 Genetic barcodes  
Herein are described multicolor FISH probe sets termed “genetic barcodes” targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells....
9096859 Microbial conversion of plant biomass to advanced biofuels  
The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into alcohols or branched-chain...
9096647 Simplified one-pot synthesis of [18F]SFB for radiolabeling  
A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody)...
9096532 Pyrazole inhibitors of COX-2 and sEH  
The present invention provides compounds and compositions, e.g., a series of compounds wherein a 1,5-biarylpyrazole group is conjugated to a urea group by a non-cleavable covalent chain, that are...
9095852 Multilayer high density microwells  
A multilayer well device includes a first substrate comprising an array of wells having a first pattern disposed therein and a second substrate comprising an array of wells having a second...
9095579 Protection and treatment against influenza infection  
Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the...
9095414 Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea  
The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure,...
US20150214486 FIELD-EFFECT TRANSISTORS BASED ON MACROSCOPICALLY ORIENTED POLYMERS  
Methods and materials for preparing organic semiconducting layers include, for example, one used in an organic semiconductor device including a substrate with a nano structured surface and an...
US20150212119 SYSTEMS AND METHODS FOR ANALYZING BUILDING OPERATIONS SENSOR DATA  
Systems and methods are disclosed for analyzing building sensor information and decomposing the information therein to a more manageable and more useful form. Certain embodiments integrate...
US20150211979 FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING  
Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and...
US20150211077 Methods and Systems for Determining a Likelihood of Adverse Prostate Cancer Pathology  
The present disclosure provides methods that find use in determining a likelihood of adverse prostate cancer pathology in a subject. The methods generally involve detection of one or more...
US20150211037 POLYPEPTIDES FOR USE IN THE DECONSTRUCTION OF CELLULOSE  
Hydrolysis and degradation of cellulose-containing biomass by use of a polypeptide having cellulase activity is provided. Also provided are polypeptides having cellulase activity, such as archaeal...
US20150210592 REACTIVE LIMESTONE AS A STRATEGY TOWARDS SUSTAINABLE, LOW-CARBON CEMENTS  
A manufacturing process of a “low cement content” concrete includes: (1) forming a cementitious mixture by combining a cement, a carbonate source, and an aluminous source; and (2) curing the...
US20150209586 INTEGRATED NANOWIRE ARRAY DEVICES FOR DETECTING AND/OR APPLYING ELECTRICAL SIGNALS TO TISSUE  
An integrated nanowire device includes a first array of nanowires having a first set of characteristics and a second array of nanowires having a second set of characteristics. A processor is...
US20150209514 SYSTEM AND METHOD FOR CLOSED-LOOP PATIENT-ADAPTIVE HEMODYNAMIC MANAGEMENT  
A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with...
US20150209409 USES OF IL-12 IN HEMATOPOIESIS  
Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the...
US20150209361 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer  
A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that...
US20150209335 METHODS AND SMALL MOLECULE THERAPEUTICS COMPRISING FUSED ELPS  
This disclosure provides a novel compositions and methods to deliver small molecule therapeutics using genetically engineered protein polymers connected to the ‘cognate’ human protein target of...
US20150209084 METHOD AND DEVICE FOR RESTABILIZATION WITH AXIAL ROTATION OF THE ATLANTOAXIAL JUNCTION  
An apparatus for stabilizing an atlantoaxial junction while allowing for axial rotation in cases of acquired ligamentous injury or fracture of the dens.
9093818 Nanopillar optical resonator  
Monolithically integrated optical resonators are disclosed. An optical resonator may be a nanopillar optical resonator that is formed directly on a substrate and promotes a helically-propagating...
9093248 Triboelectric X-ray source  
An x-ray source for generating x-rays with at least one narrow energy band includes an enclosing vessel, a first contact arranged with a first contact surface in the enclosing vessel, a second...
9090865 Systems and methods for particle classification and sorting  
A particle analysis system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a...
9090860 Process for creating shape-designed particles in a fluid  
A method for producing particles includes providing a relief template having a surface relief pattern adapted to impart structure to a plurality of particles while they are under production;...
9090589 Specific nNOS inhibitors for the therapy and prevention of human melanoma  
Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other...
9089698 Method and apparatus for optogenetic treatment of blindness including retinitis pigmentosa  
An apparatus for in vivo electroporating a plasmid into a retina of any eye includes a first electrode with a first polarity of voltage placed in contact with a cornea of the eye, a second...
9089677 Transcutaneous multimodal delivery system (TMDS)  
A transcutaneous multimodal delivery device for drug delivery and the methods of making and using the same are provided.
9089667 Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery  
A step-design cannula and delivery system for chronic delivery of therapeutic substances into the brain using convention-enhanced delivery of therapeutic substances and which effectively prevents...
9089600 Systems and methods for in vitro and in vivo imaging of cells on a substrate  
Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging...
9089531 GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes  
In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the...
9089498 Multifunctional nanoparticle designs and applications  
Methods, structures, devices and systems are disclosed for fabricating and implementing nanoparticles with hollow core and sealable holes. In one aspect, a nanoparticle device can includes a shell...
9089315 Methods and devices for adjunctive local hypothermia  
Devices and methods for using adjunctive cooling to promote recovery of function following pelvic surgery include a uretral catheter and a cryogenic cautery device. A system for producing chilled...
9089269 System and method for reconstructing cardiac signals associated with a complex rhythm disorder  
System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the...
US20150207990 MONOCENTRIC LENS DESIGNS AND ASSOCIATED IMAGING SYSTEMS HAVING WIDE FIELD OF VIEW AND HIGH RESOLUTION  
Methods, systems, and devices are disclosed for capturing and forming large high quality images using monocentric optical imaging. In one aspect, an optical imaging system includes an optical...
US20150207171 THIN FILM ELECTROLYTE BASED 3D MICRO-BATTERIES  
Embodiments of a 3D micro-battery structure are disclosed. The 3D micro-battery structure includes an electrode micro-structure and a thin film electrolyte. The electrode micro-structure includes...
US20150207106 HIGH EFFICIENCY ORGANIC LIGHT EMITTING DEVICES  
A method for producing high efficiency organic light emitting devices, that have an organic semiconductor active layer sandwiched between electrodes where at least one of the electrodes is a film...
US20150207060 MAGNETIC AND ELECTRICAL CONTROL OF ENGINEERED MATERIALS  
Methods, systems, and devices are disclosed for controlling the magnetic and electrical properties of materials. In one aspect, a multi-layer structure includes a first layer comprising a...
US20150205090 METHODS FOR OPTICAL AMPLIFIED IMAGING USING A TWO-DIMENSIONAL SPECTRAL BRUSH  
An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode...
US20150204887 HUMAN MYELOID DERIVED SUPPRESSOR CELL CANCER MARKERS  
Provided herein are methods for determining the presence of cancer (malignant versus benign), monitoring the progression of cancer, monitoring cancer relapse, monitoring the response to cancer...
US20150204860 BIOMOLECULAR DETECTION TEST STRIP DESIGN  
Described here are a device and a method for detecting the presence of a biomarker using the device, wherein the device comprises (a) a substrate comprising a plurality of electrodes; (b) a...
US20150204773 HIGH THROUGHPUT LENS-FREE THREE-DIMENSIONAL TRACKING OF SPERM  
A system for three dimensional imaging of motile objects includes an image sensor and a sample holder disposed adjacent to the image sensor. A first illumination source is provided and has a first...
US20150203884 METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS  
The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.