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Patents and Patent Applications from University of California System


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US20150038351 Gene Signatures That Predispose Or Protect Individuals From Low-Dose Radiation Induced Breast Cancer Or Are Associated with Disease-Free Survival  
A method for identifying sensitivity to low-dose ionizing radiation and cancer patient prognosis. Several predictor panels of genes that are predictive for increased or decreased susceptibility for...
US20150037845 THERMOPHILIC MUTANTS OF TRICHODERMA REESEI ENDOGLUCANASE I  
The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to...
US20150037789 SYSTEMIC GENOTOXICITY AS BLOOD MARKER FOR ALLERGIC INFLAMMATION  
The invention provides a method for detection of allergic inflammation in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An...
US20150037766 CONVEX EQUILATERAL POLYHEDRA WITH POLYHEDRAL SYMMETRY  
A new class of polyhedron is constructed by decorating each of the triangular facets of an icosahedron with the T vertices and connecting edges of a “Goldberg triangle.” A unique set of int...
US20150037370 DIATOM-BASED VACCINES  
This invention provides diatom-based vaccines.
US20150037369 Methods of Transforming a Listeria  
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many...
US20150037364 ADENOVIRUSES AND THEIR USE  
Baboon Adenovirus (BaAdV)-2/4 and BaAdV-3 are disclosed herein. BaAdV-2/4 and BaAdV-3 polynucleotide, polypeptides and antibodies that specifically bind BaAdV-2/4 and/or BaAdV-3 are disclosed....
US20150037320 TREATMENT OF MACROPHAGE-RELATED DISORDERS  
The present invention provides a method of treating a macrophage related disease comprising administering to a subject in need thereof an effective amount of an oxidative agent or an...
US20150036337 LASER-DRIVEN WHITE LIGHTING SYSTEM FOR HIGH-BRIGHTNESS APPLICATIONS  
A high-power, high-brightness lighting system for large venue lighting, which includes a laser diode as the excitation source and one or more phosphor materials placed at a remote distance from the...
US20150035110 PYROELECTRIC ALUMINUM NITRIDE MEMS INFRARED SENSOR WITH SELECTIVE WAVELENGTH INFRARED ABSORBER  
A MEMS sensor for detecting electromagnetic waves in a particular frequency range is provided. In a preferred embodiment, the MEMS sensor comprises a bottom substrate layer; a first electrode layer...
US20150034881 ELECTRONICALLY CONDUCTIVE POLYMER BINDER FOR LITHIUM-ION BATTERY ELECTRODE  
A family of carboxylic acid group containing fluorene/fluorenon copolymers is disclosed as binders of silicon particles in the fabrication of negative electrodes for use with lithium ion batteries....
8948427 Hearing aid fitting procedure and processing based on subjective space representation  
A system for hearing assistance devices to assist hearing aid fitting applied to individual differences in hearing impairment. The system is also usable for assisting fitting and use of hearing...
8947123 Wave dynamic differential logic  
Wave Dynamic Differential Logic (WDDL) is provided, wherein a differential logic stage is pre-charged or pre-discharged by a previous logic stage, such as, for example, a previous SDDL stage, a...
8946455 Semi-synthetic small molecules for the treatment parasitic disease  
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping...
8946454 Chemical framework compositions and methods of use  
The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.
8946408 Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source  
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides using fluorescent light.
8946391 Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition  
The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to...
8946379 Bladder cancer specific ligand peptides  
The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for...
8946165 Compounds for reversing and inhibiting protein aggregation, and methods for making and using them  
The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for...
8945858 Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory  
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and...
8945722 Materials and architectures for efficient harvesting of singlet and triplet excitons for white light emitting OLEDs  
The present invention relates to organic light emitting devices (OLEDs), and more specifically to OLEDS that emit light using a combination of fluorescent emitters and phosphorescent emitters for...
8945604 Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication  
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device...
8945602 Porous photonic crystals for drug delivery to the eye  
A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores...
8945595 Insect repellent and attractants  
The disclosure provides compounds useful as insect repellents and compositions comprising such repellents. The disclosure further provides insect traps.
8945502 Patterned, dense and high-quality SWNTs arrays  
An electronics component is disclosed herein. The electronics component include a substrate and a plurality of single-walled carbon nanotubes (SWNTs) formed on said substrate, wherein said...
8945482 System, method and device for tissue-based diagnosis  
The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising...
8944799 Techniques for sensing material flow rate in automated extrusion  
An extrusion construction system may include an extrusion nozzle, a channeling element coupled to the extrusion nozzle and to a source of construction material, the channeling element configured to...
US20150033371 HAIR FOLLICLE STEM CELLS AND METHODS OF USE SAME  
The disclosure provides isolated hair follicle stem cells (hfSC) having inactivated BMP signaling, which are discovered to express keratin 15. Also provided are hfSC that have constitutively...
US20150032990 Scalable and Parameterized VLSI Architecture for Compressive Sensing Sparse Approximation  
Systems and methods for implementing a scalable very-large-scale integration (VLSI) architecture to perform compressive sensing (CS) hardware reconstruction for data signals in accordance with...
US20150032034 APPARATUS AND METHOD FOR QUANTIFYING STABILITY OF THE KNEE  
A wireless motion sensor platform comprising MEMS inertial sensors and accompanying software for classification of diverse motion characteristics and kinematics of patient anatomy at high...
US20150031881 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF  
This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases....
US20150031871 RNA-Mediated Gene Modulation  
An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene. Also disclosed are a composition comprising a chemokine and an isolated RNA of...
US20150031855 Methods for Enhancing Bacterial Cell Display of Proteins and Peptides  
Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display...
US20150031725 COMPOSITIONS AND METHODS FOR TREATING CANCER  
Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
US20150031625 TARGETED VECTORS FOR CANCER IMMUNOTHERAPY  
This invention provides compositions and methods for treating cancer. More specifically this invention is directed to a targeted retroviral vector comprising a cytokine gene that can be...
US20150031024 ENZYMATIC PREPARATION OF 10 BASE TO 50 KB DOUBLE-STRAND DNA REAGENT FOR SEQUENCING WITH A NANOPORE-POLYMERASE SEQUENCING DEVICE  
The invention herein disclosed provides for devices, reagents, and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme,...
US20150030678 Methods and Compositions for Treating Wounds and Reducing the Risk of Incisional Hernias  
Provided are methods and compositions for treating a wound in a subject. The methods include applying a pharmaceutical composition that includes a first precursor material agent including...
US20150030600 Antibodies for Botulinum Neurotoxins  
The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those...
US20150028265 CONJUGATED POLYMERS FOR ELECTRONIC DEVICES  
A conjugated polymer for electronic devices can include a repeated unit having the structure of formula (I)
US20150027957 Collection Tubes Apparatus, Systems, and Methods  
Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the...
US20150026967 CHEMICAL PROTECTION OF METAL SURFACE  
An electrochemical cell includes an anode having a metal material having an oxygen containing layer. The electrochemical cell also includes a cathode and an electrolyte. The anode includes a...
8943080 Systems and methods for identifying parallel documents and sentence fragments in multilingual document collections  
Systems, computer programs, and methods for identifying parallel documents and/or fragments in a bilingual collection are provided. The method for identifying parallel sub-sentential fragments in a...
8940918 Amyloid binding agents  
There are provided compounds and methods for the detection of amyloids and treatment of diseases related to amyloids including Alzheimer's disease and other related amyloid-based neurodegenerative...
8940871 Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting  
The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate,...
8940866 Detection of degradative enzymes and biomolecules in bodily fluids  
Provided herein are compositions useful in detecting degradative enzymes and biomolecules in bodily fluid samples.
8940705 Method of treating disease and selectively modulating transcriptional regulation by a glucocorticoid receptor by administering aclacinomycin and dexamethasone  
The invention relates to assays to detect selective gene regulation by ligand dependent transcription factors. The invention also relates to selective modulators of the glucocortocoid receptor for...
8940506 High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins  
The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of...
8940491 Genotoxicity as a biomarker for inflammation  
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated...
8940313 Tyrosine-based prodrugs of antiviral agents  
A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of...
8940298 High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection  
The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis,...