Patents and Patent Applications from University of California System


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9778164 Fluidic flow cytometry devices and particle sensing based on signal-encoding  
Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and...
9777701 Carpet of wave energy conversion (CWEC)  
A carpet of wave energy conversion (CWEC) device mechanically couples an absorber carpet to one or more energy converters, thereby allowing for wave energy extraction from passing waves. The...
9777340 Compositions and methods for detecting human Pegivirus 2 (HPgV-2)  
Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and...
9777300 Hybrid organic-inorganic system for producing biofuels  
The present invention provides for a system for converting CO2 and H2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more...
9775932 Nanostructure surface coated medical implants and methods of using the same  
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a...
9775859 Methods and compositions for preventing and treating a disease related to glycan dysregulation  
Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune...
9775852 Acyclic nucleoside phosphonate diesters  
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside...
US20170279739 PREDICTIVE NETWORK SYSTEM AND METHOD  
A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless...
US20170279122 Redox-Active Supramolecular Polymer Binders Derived from Perylene Bisimide Nanowires Enable High-Rate Lithium-Sulfur Batteries  
To address the need for multi-functional binders specifically tailored for sulfur cathodes π-stacked perylene bisimide (PBI) molecules are repurposed as redox-active supramolecular binders in...
US20170278643 DEVICES AND METHODS FOR HIGH VOLTAGE AND SOLAR APPLICATIONS  
Provided herein are devices comprising one or more cells, and methods for fabrication thereof. The devices may be electrochemical devices. The devices may include three-dimensional...
US20170278261 METHOD FOR QUANTIFYING PRODUCE SHAPE  
The disclosure provides for an image processing method for quantifying produce shape. The disclosure further provides for the use of the image processing method for various applications, including...
US20170276664 EVAPORATION ON SUPERHYDROPHOBIC SURFACES FOR DETECTION OF ANALYTES IN BODILY FLUIDS  
This disclosure provides a diagnostic system including a detection zone adapted to receive a volume of biological fluid. The detection zone includes a plurality of micro-scale and nano-scale...
US20170275681 SINGLE MOLECULE RNA DETECTION  
Quantification of RNAs is one of the most essential tools to characterize cells. This tool is widely used in disease diagnosis, pharmacogenomics, and drug development. Single cell RNA fluorescent...
US20170275650 ENDOSOMAL ESCAPE DOMAINS FOR DELIVERY OF MACROMOLECULES INTO CELLS  
The disclosure provides fusion polypeptides and constructs useful for delivering diagnostics and therapeutics to cells. The fusion constructs include a protein transduction domain, a endosomal...
US20170275399 ANION-COORDINATING POLYMER ELECTROLYTES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit...
US20170275249 SMALL LIPOPEPTIDOMIMETIC INHIBITORS OF GHRELIN O-ACYL TRANSFERASE  
Compositions and methods are disclosed that relate to small molecule lipopeptidomimetic inhibitors of mammalian ghrelin O-acyl transferase (GOAT). Compounds of general Formula (I) and...
US20170274734 DETECTING RESIDUAL HOST CELL PROTEINS IN RECOMBINANT PROTEIN PREPARATIONS  
This application provides a method of using aptamers to determine the presence of HCP's in a recombinant protein preparation, and provides methods of preparing a plurality of aptamers for use in...
US20170274363 PALLADIUM HYDRIDE NANOMATERIALS  
A palladium hydride nanomaterial includes nanostructures having a chemical composition represented by the formula: My—PdxHz, where M is at least one metal different from palladium; x has a...
US20170274209 REGULATION OF AUTONOMIC CONTROL OF BLADDER VOIDING AFTER A COMPLETE SPINAL CORD INJURY  
In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a...
US20170274087 SACCHARIDE ANALOGS AND AGENTS FOR THE DIAGNOSIS AND THERAPY OF BACTERIAL INFECTIONS  
This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a...
US20170274059 Self-Antigen Displaying Nanoparticles Targeting Auto-Reactive Immune Factors and Uses Thereof  
The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the...
US20170274047 ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1. 3 POTASSIUM CHANNELS  
Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety,...
US20170273793 ASSEMBLY OF LAYERED MONETITE-CHITOSAN NANOCOMPOSITE AND ITS TRANSITION TO ORGANIZED HYDROXYAPATITE  
A multilayer structure that functions as a bone replacement material includes a plurality of organic matrix layers such that each organic matrix layer includes chitosan and a dicarboxylic acid....
US20170273594 REAL-TIME STIMULATION ARTIFACT SUPPRESSION FOR SIMULTANEOUS ELECTROPHYSIOLOGICAL ELECTRICAL STIMULATION AND RECORDING  
A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus...
US20170273578 CARDIAC PHASE-RESOLVED NON-BREATH-HOLD 3-DIMENSIONAL MAGNETIC RESONANCE ANGIOGRAPHY  
3D cine MR angiography systems and methods are disclosed for use during the steady state intravascular distribution phase of ferumoxytol. The 3D cine MRA technique enables improved delineation of...
9773986 Copper(I)-carbene complexes and organic electroluminescent devices  
Devices comprising an organic light emitting device are provided. The devices can include an anode; a cathode; and an organic layer, disposed between the anode and the cathode. The organic layer...
9773704 Method for the reuse of gallium nitride epitaxial substrates  
A method for the reuse of gallium nitride (GaN) epitaxial substrates uses band-gap-selective photoelectrochemical (PEC) etching to remove one or more epitaxial layers from bulk or free-standing...
9773663 Self-limiting and saturating chemical vapor deposition of a silicon bilayer and ALD  
Embodiments described herein provide a self-limiting and saturating Si—Ox bilayer process which does not require the use of a plasma or catalyst and that does not lead to undesirable substrate...
9773574 Systems and methods for enhancing isolation of high-temperature reactor containments  
A high-temperature containment-isolation system for transferring heat from a nuclear reactor containment to a high-pressure heat exchanger is presented. The system uses a high-temperature,...
9772554 Copolymer formulation for directed self-assembly, methods of manufacture thereof and articles comprising the same  
Disclosed herein is a pattern forming method comprising providing a substrate devoid of a layer of a brush polymer; disposing upon the substrate a composition comprising a block copolymer...
9772334 Inflammatory bowel disease markers and therapies for colitis-associated intestinal fibrosis  
Method of diagnosing and treating inflammatory bowel disease are disclosed herein. Inflammatory bowel disease can be treated and diagnosed using cathelicidin peptides and detection agents thereof....
9772280 Portable broadband diffuse optical spectroscopic imaging (DOSI) device for noninvasive tissue characterization  
A diffuse optical spectroscopic imaging (DOSI) apparatus for tissue spectroscopy measures absorption and scattering properties of tissue using multi-frequency frequency domain photon migration in...
9771625 Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer  
A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer...
9771592 Methods and compositions for treating or preventing pruritis  
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
9771428 CD47 targeted therapies for the treatment of infectious disease  
Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRPα on a host...
9770721 Continuous whole-chip 3-dimensional DEP cell sorter and related fabrication method  
A 3-dimensional PDMS cell sorter having multiple passages in a PDMS layer that follow the same path in a DEP separation region and that are in fluid communication with each other within that...
9770280 Implantable thermal treatment method and apparatus  
A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An...
9770195 Automated scratch detection system and signal processing algorithm for the study of pruritus in animals  
The invention provides a method for automated assessment of pruritus comprising detecting movement of a band located on a limb of a subject animal so as to obtain a signal associated with the...
9770169 Systems and methods for monitoring eye health  
Systems and methods for monitoring eye health. The systems and methods monitor eye health by measuring scleral strain by way of an implantable monitor, a wearable monitor configured in eyeglasses,...
US20170272171 PHASE-SENSITIVE REGENERATION WITHOUT A PHASE-LOCKED LOOP USING BRILLOUIN AMPLIFICATION  
Methods, systems, and apparatus for phase-sensitive regeneration of a signal without a phase-locked loop and using Brillouin amplification. The system for phase-sensitive regeneration includes a...
US20170271877 REAL-TIME DISAGGREGATION OF RENEWABLE ENERGY GENERATION ON AN ELECTRICITY DISTRIBUTION SYSTEM  
Techniques are described for disaggregation of renewable energy generation on an electricity distribution system. Aggregate power measurements are identified a distribution substation. Active...
US20170271093 CAPACITOR WITH ELECTRODES MADE OF AN INTERCONNECTED CORRUGATED CARBON-BASED NETWORK  
Capacitors having electrodes made of interconnected corrugated carbon-based networks (ICCNs) are disclosed. The ICCN electrodes have properties that include high surface area and high electrical...
US20170269034 TWO-CHAMBER DUAL-PORE DEVICE  
Provided is a device comprising a channel through and defined by a plurality of layers surrounding the channel, the channel connecting a first and a second chambers separated by the plurality of...
US20170268031 METHODS FOR BACTERIOPHAGE DETECTION  
Provided are methods and devices for the detection of bacteriophages.
US20170267994 Vaccine for Livestock Production Systems  
The invention relates to a live vaccine for protection against enteric bacterial infection.
US20170267768 Protein A Binding Polypeptides, Anti-EphA2 Antibodies and Methods of Use Thereof  
Provided by the present disclosure are antibodies (e.g., scFvs) that include CDRs and human framework regions that confer useful properties upon the antibodies. In certain embodiments, such...
US20170267732 COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN  
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or...
US20170267651 TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
US20170266440 FLEXIBLE AND STRETCHABLE ELECTRODES FOR GASTROINTESTINAL IMPLANTS  
A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap...
US20170266256 METHODS OF PROMOTING TISSUE HEALING AND REPAIR  
Provided herein is a method of promoting tissue repair, comprising delivering to a subject a therapeutically effective amount of fibromodulin (FMOD), FMOD polypeptide, FMOD peptide, or a variant...