Patents and Patent Applications from University of California System


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9605078 Pictet-Spengler ligation for protein chemical modification  
Aldehyde- and ketone-functionalized proteins are promising new substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are...
9605031 In vitro reconstituted plant virus capsids for delivering RNA genes to mammalian cells  
The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (CCMV CP) and a ribonucleic acid, as well as methods for using such compositions. In such...
9604973 Anti-cancer polyketide compounds  
Provided herein, inter alia, are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection...
9604955 Chemical enhancement by nanomaterials under X-ray irradiation  
A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was...
9604907 Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics  
Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or...
9604056 Methods and systems for treating neurological movement disorders  
The present disclosure provides methods for reducing the clinical presentations of a neurological movement disorder in a subject. Aspects of the methods include measuring cortical local field...
9604039 Unobstructing microdevices for self-clearing implantable catheters  
A self-clearing actuator configured to be positioned in a pore providing fluid communication into a central lumen of a ventricular catheter body is described. The actuator extends into a central...
9603796 Controlled release antimicrobial compositions and methods for the treatment of otic disorders  
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual...
9603674 Method to protect the esophagus and other mediastinal structures during cardiac and thoracic interventions  
Devices and methods are disclosed for preventing injury to a target tissue in proximity to the heart. The methods may include the use a device to externally manipulate the heart to move a portion...
9603366 Use of 9-beta-D-adenosine to increase crop production  
Described are compositions and methods to increase bud break in order to increase aspects of one or both of plant vegetative and reproductive growth, by use of a natural metabolite. In particular,...
US20170084954 CATALYST AND BATTERY COMPONENTS DERIVED FROM CONDENSATION REACTIONS WITH CARBA-CLOSO-DODECABORATE AMINES  
Described herein is the fusion of two families of unique carbon-containing molecules that readily disregard the tendency of carbon to form four chemical bonds, namely N-heterocyclic carbenes...
US20170084322 FAST AND LOW-POWER SENSE AMPLIFIER AND WRITING CIRCUIT FOR HIGH-SPEED MRAM  
A fast and low-power sense amplifier and writing circuit for high-speed Magnetic RAM (MRAM) which provides the long retention times and endurance of magnetic tunnel junction (MTJ) cells, while...
US20170082635 MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS  
Provided herein is synthesis of novel mass spectrometry-cleavable cross-linking agents. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry, tandem mass...
US20170081346 MESOSCOPIC MATERIALS COMPRISED OF ORDERED SUPERLATTICES OF MICROPOROUS METAL-ORGANIC FRAMEWORKS  
The disclosure provides for MOF heterolites comprised of ordered superlattices of MOFs, the manufacture thereof, and the use of the MOF heterolites for various applications, such as gas separation...
US20170081345 METAL-ORGANIC FRAMEWORKS CHARACTERIZED BY HAVING A LARGE NUMBER OF ADSORPTION SITES PER UNIT VOLUME  
The disclosure provides for metal organic frameworks characterized by having a high number of linking moieties connected to metal clusters and a large number of adsorption sites per unit volume....
US20170080094 MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE  
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or...
US20170080088 TUMOR RADIOSENSITIZATION WITH MONOMETHYL AURISTATIN E (MMAE) AND DERIVATIVES THEREOF  
Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule...
US20170079909 Hydrogel Toxin-Absorbing or Binding Nanoparticles  
The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the...
US20170079825 TORQUE-COMPENSATING ASSISTIVE WRIST BRACES  
In one embodiment, a torque-compensating assistive wrist brace includes a hand member adapted to be provided on a user's hand, a forearm member adapted to be provided on the user's forearm, and an...
US20170079274 METHODS FOR ASSESSING REPELLANT QUALITY OF ORGANIC MATERIALS AND METHODS AND COMPOSITIONS FOR REPELLING ARTHROPODS  
The disclosure provides compounds useful as insect repellents, compositions comprising such repellents, and methods of repelling an arthropod using such compounds and compositions. The disclosure...
9602157 Full-duplex self-interference cancellation systems  
Embodiments of full-duplex self-interference cancellation systems are described. In one embodiment, a full-duplex transceiver includes a digital signal processor that processes digital signals, a...
9601789 Self-pumping membraneless fuel cell  
The present invention is directed to a device, and method of operation, for a fuel cell which uses bubble-based pumping to self-pump the fuel to the anode, and a single, common channel separating...
9601280 Micro electromagnetically actuated latched switches  
Micro-electromagnetically actuated latched miniature relay switches formed from laminate layers comprising a spring and magnet, electromagnetic coils, magnetic latching material, and transmission...
9600990 System and methods for generating predictive combinations of hospital monitor alarms  
Systems and methods are disclosed for monitoring data associated with a plurality of physiological characteristics of a patient, comprising: the methods include generating a set of super-alarm...
9599584 Imbedded chip for battery applications  
Provided are methods, systems and devices for thermodynamically evaluating electrochemical systems and components thereof, including electrochemical cells such as batteries. The present systems...
9598480 Recombinant NEL-like (NELL) protein production  
The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a non-insect secretory signal peptide.
9598404 Deoxycytidine kinase inhibitors  
Provided herein are compounds that bind to dCK and methods for treating cancer.
9598395 Premature-termination-codons readthrough compounds  
Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
9598383 Reactive oxygen species-based prodrugs  
Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.
9598340 Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds  
The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further...
9598314 Corrosion inhibiting cementitious compositions  
Provided herein is a cementitious composition comprising a photoactivator, wherein the photoactivator is capable of converting NOx to NO2— or NO3— when exposed to ultraviolet (U.V.) or visible light.
9598281 Nanopipette apparatus for manipulating cells  
Disclosed herein are methods and systems for controlled ejection of desired material onto surfaces including in single cells using nanopipettes, as well as ejection onto and into cells. Some...
9597427 Radioactive bone cement  
A target tissue can be treated with a radioisotope. Some methods for treating a target tissue with a radioisotope include determining a distance between a target tissue and a surface of a matrix...
9597372 Vault complexes for cytokine delivery  
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault...
9597370 Method for promoting hair growth  
The present disclosure relates to a method of applying a pharmaceutical composition for promoting hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes...
9597336 Therapy for treatment of chronic degenerative brain diseases and nervous system injury  
In one aspect, the present invention provides neuroactive steroids for use in the treatment of nervous system disorders, degenerative brain diseases and congenital storage diseases. In a second...
9597241 Lever-operated wheelchair  
In one embodiment, a wheelchair drive mechanism adapted to mount to a wheelchair includes a drive lever adapted to be rotated forward and rearward by a user of the wheelchair, a clutch mechanism...
9597007 Methods for the identification and targeting of brain regions and structures and treatments related thereto  
Disclosed herein are methods for identifying and targeting brain regions and brain structures. In one embodiment, a method of identifying a brain structure in a patient comprises imaging a brain...
9597006 Burst suppression monitor for induced coma  
Methods and systems for monitoring subjects, analyzing EEG data, and maintaining subjects at desired sedation states using automatic processing systems to determine a mean burst suppression...
9596855 Small molecule inhibitors of biofilm formation and the novel use of previously identified compounds for inhibition of biofilm formation and applications for drug therapy and medical device coating  
Small molecule compound having a fused heterocyclic ring structure that are substituted derivatives of the Auromomycin Chromophore having the general formula:
US20170079144 FABRICATION OF FLEXIBLE ELECTRONIC DEVICES  
Disclosed are methods for fabrication of flexible circuits and electronic devices in cost effective manner that can include integration of submicron structures directly onto target substrates...
US20170077667 QUANTUM CASCADE EXTERNAL CAVITY LASER WITH METASURFACES  
A metasurface reflector for quantum cascade lasing is disclosed. The metasurface reflector uses an array of subcavities disposed on a substrate and spaced with a sub-wavelength period. Each of the...
US20170077356 MULTISTEP DEPOSITION OF ZINC OXIDE ON GALLIUM NITRIDE  
A method for fabricating a Zinc Oxide (ZnO) conductive film on a semiconductor material, including depositing a doped ZnO seed layer on a diode, wherein the ZnO seed layer forms an electrical...
US20170077182 MEMRISTORS AND METHOD FOR FABRICATING MEMRISTORS  
There are disclosed memristors and memristor fabrication methods. A memristor may include a stack of four functional elements including, in sequence, a first electrode, a barrier layer, an...
US20170077046 PHYSICAL UNCLONABLE FUNCTIONS THROUGH LOCALLY ENHANCED DEFECTIVITY  
A physical unclonable function (PUF) includes multiple logic gates and multiple random signal generation circuits connected to the logic gates, wherein, in at least a subset of the logic gates,...
US20170076637 CALCIFIED POLYMERIC VALVE AND VESSELS FOR VALVE-IN-VALVE APPLICATIONS  
Described is a group of polymeric calcific heart valves with different levels of calcification that can be used for research and development studies related to transcatheter heart valve...
US20170076488 PRECOMPUTING DATA FOR AN INTERACTIVE SYSTEM HAVING DISCRETE CONTROL INPUTS  
A computer-implemented method includes accessing a plurality of sets of outputs for an interactive animation, with each set of outputs being associated with a different sequence of a plurality of...
US20170076448 IDENTIFICATION OF INFLAMMATION IN TISSUE IMAGES  
Systems and methods are provided for identifying markers for inflammation in a tissue image. The tissue image is captured as an image of a histology slide. Subcellular structures in the tissue...
US20170074849 A TEST STRIP FOR MELAMINE DETECTION  
Described here is a test strip for detection of melamine, comprising: a support configured for capillary flow of a fluid sample from a first end of the support to a second end of the support that...
US20170074746 METHODS FOR DETECTION, MARKING AND SEALING LEAKS IN PIPES OR DUCTS  
A system and method for remote detection, marking and/or sealing leaks in pipe or duct networks are provided. Aerosolized sealant particles that have a surface tackiness that diminishes over time...