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Patents and Patent Applications from University of California System


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8679510 Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia  
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In...
8679476 Interferon-β production modulating Listeria strains and methods for using same  
Mutant Listeria bacteria that modulate interferon-B production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene,...
8678871 Electronic displays using optically pumped luminescent semiconductor nanocrystals  
A multicolor electronic display is based on an array of luminescent semiconductor nanocrystals. Nanocrystals which emit tight of different colors are grouped into pixels. The nanocrystals are...
US20140081353 PULSE GENERATOR FOR CRANIAL NERVE STIMULATION  
Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source...
US20140081257 BLADDER DENERVATION FOR TREATING OVERACTIVE BLADDER  
A device and method for transvaginal or transrectal treatment of a bladder pathology. The device includes an elongate body that includes a longitudinal axis, a handle at one end of the body, a head...
US20140081201 SYSTEM AND METHOD FOR CLOSED-LOOP PATIENT-ADAPTIVE HEMODYNAMIC MANAGEMENT  
A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with...
US20140081014 CONDUCTIVE OPEN FRAMEWORKS  
The disclosure relates generally to materials that comprise conductive covalent organic frameworks. The disclosure also relates to materials that are useful to store and separate gas molecules and...
US20140080986 REGIOREGULAR PYRIDAL[2,1,3]THIADIAZOLE PI-CONJUGATED COPOLYMERS FOR ORGANIC SEMICONDUCTORS  
A method of regioselectively preparing a pyridine-containing compound is provided. In particular embodiments, the method includes reacting halogen-functionalized pyridal[2,1,3]thiadiazole with...
US20140080896 IDENTIFICATION OF SMALL MOLECULES THAT FACILITATE THERAPEUTIC EXON SKIPPING  
This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of a small molecule selected from the...
US20140080821 PYRIMIDO-PYRROLO-OXAZINE-DIONE COMPOUND INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND USES THEREFOR  
Provided herein are benzopyrimido-pyrrolo-oxazine-dione (BPO) compounds and pyrimido-pyrrolo-quinoxalinedione (PPQ) compounds, and compositions comprising these compounds, that inhibit cystic...
US20140080209 METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND  
This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of...
US20140080198 MOLECULAR ZIPPER TWEEZERS AND SPRING DEVICES  
Techniques, structures, devices and systems are disclosed for implementing molecular zipper tweezers and springs. In one aspect, a molecular device includes three molecular components including at...
US20140080171 OPTICAL CYTOMETRY  
The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like....
US20140080084 CYCLIC INTERRUPTIVE FORCE ORTHODONTIC DEVICE AND SYSTEM  
Provided herein is a cyclic interruptive force orthodontic device and a system comprising the same. Methods of making and using the same are also provided.
US20140079775 AGENTS TO TREAT/PREVENT AMOEBIASIS  
The invention provides formulations comprising isolated lacto-N-tetraose (LNT) or galactooligosaccharides (GOS) or variants, isomers, analogs and derivatives thereof and a pharmaceutically...
US20140079668 TARGETED INTERFERONS DEMONSTRATE POTENT APOPTOTIC AND ANTI-TUMOR ACTIVITIES  
Novel chimeric moieties that show significant efficacy against cancers are provided. In certain embodiments the chimeric moieties comprise a targeting moiety attached to an interferon. In certain...
US20140079637 METHODS AND COMPOSITIONS FOR IMPROVING ANTIANGIOGENIC THERAPY WITH ANTI-INTEGRINS  
Described here are methods and compositions for treating tumors and metastases that improve anti-angiogenesis therapy. By inhibiting these mechanisms in a biological system with an anti-beta one...
US20140079571 MICROFLUIDIC OSCILLATOR PUMP  
Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an...
US20140077161 HIGH PERFORMANCE GRAPHENE TRANSISTORS AND FABRICATION PROCESSES THEREOF  
A graphene transistor includes: (1) a substrate; (2) a source electrode disposed on the substrate; (3) a drain electrode disposed on the substrate; (4) a graphene channel disposed on the substrate...
US20140076403 DIPYRIN BASED MATERIALS FOR PHOTOVOLTAICS, COMPOUNDS CAPABLE OF UNDERGOING SYMMETRY BREAKING INTRAMOLECULAR CHARGE TRANSFER IN A POLARIZING MEDIUM AND ORGANIC PHOTOVOLTAIC DEVICES COMPRISING THE SAME  
The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of...
8676303 Methods and systems for treating heart instability  
Systems and methods define an index of risk for cardiac disease by detecting cellular derangements that may lead to cardiomyopathy, heart rhythm disorders or ischemic heart disease. The markers...
8675346 Mesoporous nanocrystalline film architecture for capacitive storage devices  
A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a...
8674178 Production of cellulase enzymes in plant hosts using transient agroinfiltration  
Described herein are methods useful for producing proteins, such as enzymes, by agrofiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a cellulase, infecting...
8674134 Oligomer functionalized nanotubes and composites formed therewith  
Disclosed herein is a sequential functionalization methodology for the covalent modification of nanotubes with between one and four repeat units of a polymer. Covalent attachment of oligomer units...
8674128 Conductive organometallic framework  
The disclosure provides organometallic frameworks, catalysts and sensors. In one aspect, the organometallic framework comprises di-isocyanide group.
8674101 Nucleophilic fluorination of aromatic compounds  
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The...
8673680 Nanoneedle plasmonic photodetectors and solar cells  
The present disclosure provides a method for a catalyst-free growth mode of defect-free Gallium Arsenide (GaAs)-based nanoneedles on silicon (Si) substrates with a complementary...
8673556 Methods and apparatus for characterizing polynucleotides  
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
8673301 YKL-40 monoclonal antibody  
The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or...
US20140073981 SYSTEM AND METHOD FOR RECONSTRUCTING CARDIAC ACTIVATION INFORMATION  
An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient....
US20140073585 PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE  
Two vIRF4 (Kaposi's-sarcoma-associated-herpesvirus vIRF4) peptides, vif1, corresponding to aa202-216 of vIRF4, and vif2, corresponding to aa220-236 of vIRF4, are potent and selective HAUSP...
US20140073523 USE OF GLYCOLYTIC PATHWAYS FOR INHIBITING OR MEASURING ONCOGENIC SIGNALING  
Disclosed are methods in which glucose metabolism is correlated to oncogenesis through certain specific pathways; inhibition of certain enzymes is shown to interfere with oncogenic signaling, and...
US20140073012 ENHANCED CELLULOSE DEGRADATION  
The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. CDH-heme domain polypeptides and GH61 polypeptides and related...
US20140072975 COMPOSITIONS AND METHODS FOR DETERMINING GENETIC POLYMORPHISMS IN THE TMEM216 GENE  
In alternative embodiments, the invention provides nucleic acid sequences that are genetic polymorphic variations of the human TMEM216 gene, and TMEM216 polypeptide encoded by these variant...
US20140072955 VISUAL-SERVOING OPTICAL MICROSCOPY  
The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual...
US20140072603 IMMUNOMODULATORY MATERIALS FOR IMPLANTABLE MEDICAL DEVICES  
The present invention relates to biomaterials that interact with and regulate immune functions, as well as implantable materials and devices. In one embodiment, the present invention provides an...
US20140072580 NOVEL TARGETS FOR TREATMENT OF HYPERCHOLESTEROLEMIA  
In certain embodiments this invention this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of...
US20140072569 EMP2 ANTIBODIES AND THEIR THERAPEUTIC USES  
The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a...
US20140071732 NONVOLATILE MAGNETO-ELECTRIC RANDOM ACCESS MEMORY CIRCUIT WITH BURST WRITING AND BACK-TO-BACK READS  
Voltage controlled magneto-electric tunnel junctions (MEJ) and associated memory devices are described which provide efficient high speed switching of non-volatile magnetic random access memory...
US20140071728 READ-DISTURBANCE-FREE NONVOLATILE CONTENT ADDRESSABLE MEMORY (CAM)  
Voltage controlled magnetoelectric tunnel junction (MEJ) based content addressable memory is described which provides efficient high speed switching of MEJs toward eliminating any read disturbance...
US20140070701 ADVANCED PENNING ION SOURCE  
This disclosure provides systems, methods, and apparatus for ion generation. In one aspect, an apparatus includes an anode, a first cathode, a second cathode, and a plurality of cusp magnets. The...
US20140070344 SYSTEMS AND METHODS FOR IMPLEMENTING MAGNETOELECTRIC JUNCTIONS  
Embodiments of the invention implement DIOMEJ cells. In one embodiment, a DIOMEJ cell includes: an MEJ that includes, a ferromagnetic fixed layer, a ferromagnetic free layer, and a dielectric layer...
US20140070169 Separated Carbon Nanotube-Based Active Matrix Organic Light-Emitting Diode Displays  
A separated carbon nanotube-based active matrix organic light-emitting diode (AMOLED) device including a substrate and transistors. Each transistor includes an individual back gate patterned on the...
US20140069499 MORPHOLOGICAL AND SPATIAL CONTROL OF InP CRYSTAL GROWTH USING CLOSED-SPACED SUBLIMATION  
A new solar cell comprising a substrate, a VIB metal thin film deposited on the substrate, and a polycrystalline III-V semiconductor thin film deposited on the VIB metal thin film. A method of...
8669074 Chimeric phosphorylation indicator  
A chimeric phosphorylation indicator (CPI) as provided herein can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. Where the...
8669055 Methods and articles for strand-specific polynucleotide detection with conjugated polymers  
The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and...
8668774 Low temperature continuous circulation reactor for the aqueous synthesis of ZnO films, nanostructures, and bulk single crystals  
A method for synthesizing ZnO, comprising continuously circulating a growth solution that is saturated with ZnO between a warmer deposition zone, which contains a substrate or seed, and a cooler...
US20140068797 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION  
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a...
US20140067300 TIME STRETCH ENHANCED RECORDING SCOPE  
A time-stretched enhanced recording scope (TiSER) is described using time stretch analog-to-digital conversion in a real-time burst mode. A chirped optical signal is modulated in response to...
US20140066787 SYSTEM AND METHOD FOR RECONSTRUCTING CARDIAC ACTIVATION INFORMATION  
An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient....