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Patents and Patent Applications from University of California System


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8764666 Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging  
An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation...
US20140180998 EFFICIENT SEARCHING OF STATIONARY DATASETS  
A saliency function is computed to indicate the saliency of each of a plurality of data points in a dataset. For each local maximum in the saliency function, a segment of the dataset is inserted...
US20140180399 MESH ENCLOSED TISSUE CONSTRUCTS  
Described is a heart valve leaflet manufactured from a mesh material. The mesh material may have an ability to capture circulatory/stationary/migratory cells of the body to become biologically...
US20140180395 BIOACTIVE SPIRAL COIL COATING  
An endovascular spiral coil coating and methods of making and using the same.
US20140180361 NEUROSTIMULATOR  
A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each...
US20140180085 Renal Injury Inhibiting Devices, Systems, and Methods Employing Low-Frequency Ultrasound or Other Cyclical Pressure Energies  
Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often...
US20140180065 FIDUCIARY MARKERS AND METHODS OF PLACEMENT  
The invention relates to the field of radiation oncology, specifically the use of novel radio-opaque fiduciary markers which resist migration within tissues, which may be implanted in the body and...
US20140180052 NEURAL RECORDING SYSTEM  
A neuron recording system was provided. By using the gain-boosted topology, the amplifier input impedance can be increased while simultaneously reducing the noise. The system can be configured to...
US20140179616 PEPTIDES THAT STIMULATE SUBCUTANEOUS ADIPOGENESIS  
Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis and uses thereof are provided.
US20140179598 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE  
Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof.
US20140179046 SEMICONDUCTOR NANOCRYSTAL PROBES FOR BIOLOGICAL APPLICATIONS AND PROCESS FOR MAKING AND USING SUCH PROBES  
A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals...
US20140178865 RAPID, MASSIVELY PARALLEL SINGLE-CELL DRUG RESPONSE MEASUREMENTS VIA LIVE CELL INTERFEROMETRY  
A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change...
US20140178450 Compositions and Methods for Tissue Repair with Extracellular Matrices  
Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing...
US20140178354 Salinosporamides and Methods of Use Thereof  
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
US20140178348 Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies  
Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for...
US20140178346 CELLULAR COMPOSITIONS FOR TISSUE ENGINEERING  
Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or...
US20140177327 VOLTAGE-CONTROLLED MAGNETIC ANISOTROPY (VCMA) SWITCH AND MAGNETO-ELECTRIC MEMORY (MERAM)  
Voltage controlled magnetic tunnel junctions and memory devices are described which provide efficient high speed switching of non-volatile magnetic devices at high cell densities. Implementations...
US20140175579 METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY  
A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block...
US20140175546 PLASMONICALLY ENHANCED ELECTRO-OPTIC DEVICES AND METHODS OF PRODUCTION  
A plasmonically enhanced electro-optic device includes a dielectric layer; a plurality of nanopillars arranged in a periodic array such that each nanopillar has a protruding portion that extends...
US20140174992 DYNAMIC EQUILIBRIUM SEPARATION, CONCENTRATION, AND MIXING APPARATUS AND METHODS  
Particles are separated, concentrated, or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal...
US20140174189 DROPLET-BASED CAPACITIVE PRESSURE SENSOR  
A pressure sensing apparatus which utilizes an electrolytic droplet retained between a first and second sensing electrode within a housing. Contact between the electrolyte droplet and the...
8762070 Systems, devices and methods to deliver biological factors or drugs to a subject  
A method, computer implemented method and associated apparatus for the management of diabetes comprises utilizing zone model predictive control (Zone-MPC) to control delivery of an insulin or...
8761860 MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs  
An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and...
8761243 Technique to enable efficient adaptive streaming and transcoding of video and other signals  
A method is described for efficiently determining total end-to-end distortion of a pre-compressed data stream, such as video streams or other media streams, at the time of delivery over a...
8761218 Aluminum gallium nitride barriers and separate confinement heterostructure (SCH) layers for semipolar plane III-nitride semiconductor-based light emitting diodes and laser diodes  
A semipolar plane III-nitride semiconductor-based laser diode or light emitting diode, comprising a semipolar Indium containing multiple quantum wells for emitting light, having Aluminum containing...
8759632 Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof  
The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present...
8759492 Engineered red-shifted channelrhodopsin variants  
The invention provides engineered red-shifted channelrhodopsin variants. In some embodiments, the channelrhodopsin variants are characterized by improved membrane trafficking, expression, and/or...
8759444 Conjugated polymers for use in homogeneous and solid state assays  
Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample....
8759392 Amides as inhibitors of human secreted phospholipase A2  
Methods and compounds useful for inhibiting a phoshpolipase A2 are provided, the methods comprising contacting the phoshpolipase A2 with a compound having the structure A, or pharmaceutically...
8759296 Bone morphogenic protein binding peptide  
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which...
8759116 Identification of objects using plasmon resonant particles  
A method and apparatus for identifying an object having a pattern of plasmon resonant particles (PREs) distributed in or on the object are disclosed. In the method, a field containing the pattern...
8759006 PSCA: prostate stem cell antigen and distinguishing androgen receptor negative prostate cancer from benign prostatic hyperplasia  
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade...
8758948 Iron-air rechargeable battery  
Embodiments include an iron-air rechargeable battery having a composite electrode including an iron electrode and a hydrogen electrode integrated therewith. An air electrode is spaced from the iron...
8758778 Polymeric nano-carriers with a linear dual response mechanism and uses thereof  
The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to...
8758653 Molecular optimization of multiply-functionalized mesostructured materials  
A material and method for producing mesostructured materials with multiple functionalities that are independently adjustable and collectively optimizable is provided. The method uses a series of...
US20140172763 Neural Processing Unit  
The subject matter disclosed herein provides methods, apparatus, and articles of manufacture for neural-based processing. In one aspect, there is provided a method. The method may include reading,...
US20140171779 METHOD FOR DEEP BRAIN STIMULATION TARGETING BASED ON BRAIN CONNECTIVITY  
Due to the lack of internal anatomic detail with traditional magnetic resonance imaging, preoperative stereotactic planning for the treatment of tremor usually relies on indirect targeting based on...
US20140171455 Reduction of Microglia-Mediated Neurotoxicity by Kv1.3 Inhibition  
Methods for deterring microglia-mediated neurotoxicity in a human or non-human animal subjects comprising the step of inhibiting or blocking the intermediate-conductance calcium-activated potassium...
US20140170647 Compositions and Methods for Analyzing Immobilized Nucleic Acids  
The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in...
US20140170483 METHOD FOR THE PREPARATION OF GRAPHENE/SILICON MULTILAYER STRUCTURED ANODES FOR LITHIUM ION BATTERIES  
Multilayer structures with alternating graphene and Si thin films were constructed by a repeated process of filtering liquid-phase exfoliated grapheme film and subsequent coating of amorphous Si...
US20140170204 Multilayer Thin Film Drug Delivery Device and Methods of Making and Using the Same  
Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as...
US20140170183 D-Amino Acid Derivative-Modified Peptidoglycan and Methods of Use Thereof  
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using...
US20140170162 PRESERVATION OF THE NEUROMUSCULAR JUNCTION (NMJ) AFTER TRAUMATIC NERVE INJURY  
The invention relates to treatment and/or prevention of nerve injury. In one embodiment, the present invention provides a method of preserving the neuromuscular junction (NMJ) in an individual by...
US20140170140 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROMYELITIS OPTICA  
The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with...
US20140169085 VOLTAGE-CONTROLLED MAGNETIC MEMORY ELEMENT WITH CANTED MAGNETIZATION  
A memory cell including information that is stored in the state of a magnetic bit (i.e. in a free layer, FL), where the FL magnetization has two stable states that may be canted (form an angle)...
US20140167868 Power-efficient multi-frequency resonant clock meshes  
Power-efficient resonant clock meshes and multiple frequency resonant clock distribution networks.
US20140167759 NMR BOREHOLE LOGGING DEVICE AND METHOD OF USE  
This disclosure provides systems, methods, and apparatus related to depth well logging. In one aspect, an apparatus includes a radio frequency (RF) coil and a magnetic field sensing device. The...
US20140167059 PEC ETCHING OF (20-2-1) SEMIPOLAR GALLIUM NITRIDE FOR EXTERNAL EFFICIENCY ENHANCEMENT IN LIGHT EMITTING DIODE APPLICATIONS  
A method of performing a photoelectrochemical (PEC) etch on an exposed surface of a semipolar {20-2-1} III-nitride semiconductor, for improving light extraction from and for enhancing external...
US20140167002 ORGANIC SMALL MOLECULE SEMICONDUCTING CHROMOPHORES FOR USE IN ORGANIC ELECTRONIC DEVICES  
Small organic molecule semi-conducting chromophores containing a pyridalthiadiazole, pyridaloxadiazole, or pyridaltriazole core structure are disclosed. Such compounds can be used in organic...
US20140166485 ELECTROADSORPTION AND CHARGE BASED BIOMOLECULE SEPARATION AND DETECTION IN POROUS SENSORS  
Electroadsorption and charged based biomolecule separation, concentration and detection with porous biosensors. In preferred embodiments, a potential is applied to a porous electrode to separate...