Patents and Patent Applications from University of California System


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9938350 Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof  
Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates...
9938263 Gamma-secretase modulators  
There are provided, inner alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since all of the major AB peptide variants,...
9938238 Anti-auxin compounds  
Provided herein are methods and compositions for controlling auxin responses in plants.
9938204 Intermolecular C-H silylation of unactivated arenes  
Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene...
9938157 Interzeolite transformation and metal encapsulation in the absence of an SDA  
Provided is a method of encapsulating a metal in a zeolite. The method comprises inserting a metal precursor into a parent zeolite, and then converting the parent zeolite to a zeolite having a...
9937556 Templated synthesis of metal nanorods in silica nanotubes  
A method of preparing a metal nanorod. The method includes seeding a metal nanoparticle within the lumen of a nanotube, and growing a metal nanorod from the seeded metal nanoparticle to form a...
9937141 Carcinoma diagnosis and treatment, based on ODC1 genotype  
The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular...
9937129 Materials and methods for delivering compositions to selected tissues  
This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or...
9936923 System and methods for generating predictive combinations of hospital monitor alarms  
Systems and methods are disclosed for monitoring data associated with a plurality of physiological characteristics of a patient, comprising: the methods include generating a set of super-alarm...
US20180097486 Switched Capacitor House of Cards Power Amplifier  
A circuit topology including stacked power amplifiers (e.g., class D PA cells) in a ladder arranged in a house-of-cards topology such that the number of stacked-domains follows a decaying...
US20180097249 MATERIALS FOR HIGH-PERFORMANCE AQUEOUS ORGANIC REDOX FLOW BATTERIES  
Quinones and related compounds for use in flow batteries are provided. Many of these compounds are found to mitigate the effects of crossover in a flow battery. Other structure for improving...
US20180096796 PEROVSKITE-BASED OPTOELECTRONIC DEVICE EMPLOYING NON-DOPED SMALL MOLECULE HOLE TRANSPORT MATERIALS  
An optoelectronic device includes a first electrode, a second electrode spaced apart from the first electrode, a photoactive layer that includes an organic-inorganic hybrid perovskite material...
US20180095003 OPTICAL FREQUENCY MEASUREMENT AND CONTROL USING DUAL OPTICAL-FREQUENCY COMBS  
A dual-comb optical-frequency comb generator includes a tunable comb-generating laser, a coarse-comb generator, a fine-comb generator, a second harmonic generator, a coarse-comb offset...
US20180094871 Two-Phase Cooling Devices with Low-Profile Charging Ports  
A two-phase cooling device, including a predetermined amount of at least one working fluid, a cavity formed from at least one of a metal structure or a metal alloy structure, at least one opening...
US20180094325 SOLID TUMOR METHYLATION MARKERS AND USES THEREOF  
Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the...
US20180094012 NICKEL-BASED CATALYSTS FOR C=O REDUCTION AND OXYGEN EVOLUTION  
A compound having formula I that is useful for C═O reduction is provided: wherein: M is a transition metal; X1, X2 are each independently a counterion; and R1, R2, R3 are each independently H,...
US20180093967 POTENT GAMMA-SECRETASE MODULATORS  
Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for...
US20180093960 METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND  
This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting...
US20180093454 CONTINUOUS PRODUCTION OF EXFOLIATED 2D LAYERED MATERIALS BY COMPRESSIVE FLOW  
Described herein are methods for continuous production of an exfoliated two-dimensional (2D) material comprising passing a 2D material mixture through a convergent-divergent nozzle, the 2D...
US20180092987 HOLLOW SILICA NANOSPHERES AND METHODS OF MAKING SAME  
The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene transfer.
US20180092845 ENZYME-RESPONSIVE NANOPARTICLES  
Described herein, inter alia, are compositions and methods for using block copolymers and polymeric micelles for treating myocardial infarction, cardiomyopathy, or heart failure in a subject in...
US20180092781 TELEMEDICAL WEARABLE SENSING SYSTEM FOR MANAGEMENT OF CHRONIC VENOUS DISORDERS  
A telemedical interface pressure monitoring system is provided for intermittent or continuous monitoring of the pressure that occurs at the interface between the body and a support surface such as...
9935243 Multistep deposition of zinc oxide on gallium nitride  
A method for fabricating a Zinc Oxide (ZnO) conductive film on a semiconductor material, including depositing a doped ZnO seed layer on a diode, wherein the ZnO seed layer forms an electrical...
9933502 Cardiac MRI curvilinear tagging  
A preparation sequencing system and methods are disclosed for generating curvilinear taglines of altered magnetization in an imaging plane of an NMR image. A preparation sequencing module is...
9933434 Therapeutic antibodies against ROR-1 protein and methods for use of same  
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such...
9932635 Method for exosomal biomarker detection by electric field-induced release and measurement  
The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of...
9932601 Inhibition of Snl6 expression for biofuel production  
The invention provides compositions and methods for inhibiting the expression of the gene Snl6 in plants. Plants with inhibited expression of Snl6 have use in biofuel production, e.g., by...
9932598 Metabolic engineering of microbial organisms  
Microbial strains with desirable carbohydrate productions characteristics and methods of making and using the same are provided herein.
9932391 Proteins with repetitive bacterial-IG-like (Big) domains present in Leptospira species  
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and...
9932383 Cold- and menthol-sensitive receptor (CMR1)  
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
9932359 Organic electroluminescent materials and devices  
A compound having a structure according to wherein Y is a carbene moeity coordinated to a trivalent copper atom Cu is disclosed. In Formula I, L1, L2, and L3 are three monodentate ligands. In...
9931634 High throughput DNA damage quantification of human tissue with home-based collection device  
Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also...
9931573 Optimal patrol strategy for protecting moving targets with multiple mobile resources  
The following information may be read from a memory system: an identification of each of multiple moving targets that are each expected to move in accordance with a schedule of when and where the...
9931508 Neurostimulator devices using a machine learning method implementing a gaussian process optimization  
Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord;...
9931419 Methods and compositions for liposomal formulation of antigens and uses thereof  
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These...
9931379 Oxyntomodulin analogs and methods of making and using same  
Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable...
9931332 Compositions and methods for treating primary effusion lymphoma  
Methods for treating primary effusion lymphoma (PEL) are provided. The methods include administering to a patient in need thereof an effective amount of an immunomodulatory compound. Suitable...
9930877 Microfabricated surfaces for the physical capture of insects  
Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the...
US20180090768 HOLEY GRAPHENE FRAMEWORK COMPOSITES FOR ULTRA-HIGH RATE ENERGY STORAGE AND METHODS OF PREPARING SUCH COMPOSITES  
A method of forming an electrode material includes: (1) loading an electrochemically active material onto graphene sheets; (2) combining the electrochemically active material-loaded graphene...
US20180088645 DIGITAL SIGNAL TRANSITION COUNTERS FOR DIGITAL INTEGRATED CIRCUITS  
A digital integrated circuit comprising may include a digital sensor circuit that converts binary bit patterns of wires in a sub-circuit over a given time into a single integer value that...
US20180087034 Controlled Induction of Human Pancreatic Progenitors Produces Functional Beta-Like Cells  
Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The...
US20180087029 Methods of Culturing Retinal Pigmented Epithelium Cells, Including Xeno-Free Production, RPE Enrichment, and Cryopreservation  
The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells...
US20180086796 USE OF Cyt1Aa AS BROAD SPECTRUM TARGETING DOMAIN FOR INSECTICIDAL PROTEINS WITH BASIC RESEARCH AND BIOTECHNOLOGY APPLICATIONS  
A chimeric protein comprising a cytolytic δ-endotoxin portion and a heterologous polypeptide portion is provided. Nucleic acids encoding the chimeric protein are also provided. In some cases, the...
US20180086787 ESTROGEN RECEPTOR MODULATORS  
Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
US20180086782 Guanidinoglycoside-mediated liposome-based delivery of therapeutics  
This disclosure relates to the incorporation of amphiphilic guanidinylated aminoglycosides (e.g., neomycin) into liposomal assemblies, which contain entrapped therapeutics. The lysosome is...
US20180086746 HETEROATOM CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS  
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed...
US20180086718 Diarylhydantoin Compounds  
The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
US20180085750 MICROFLUIDIC ASSISTED PERFUSION DEVICES  
The disclosure provides for microfluidic devices comprising patterned hydrogels with embedded cells or microtissues.
US20180085744 POLYMERIC MATERIALS FOR ELECTROCHEMICAL CELLS AND ION SEPARATION PROCESSES  
Polymers of intrinsic microporosity are provided herein. Disclosed polymers of intrinsic microporosity include modified polymers of intrinsic microporosity that include negatively charged sites or...
US20180085731 COMBINATION OF ISOLATED INDIVIDUAL ENHANCEMENTS OF X-RAY RADIATION EFFECT BY NANOMATERIALS  
The present disclosure relates to methods of combining chemical enhancement and physical enhancement to produce a combined synergistic total enhancement, and more specifically to methods of...