Patents and Patent Applications from University of California System


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US20180334676 SPLICE MODULATING OLIGONUCLEOTIDES THAT INHIBIT CANCER  
A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit...
US20180334654 LABEL-FREE IDENTIFICATION OF STEM CELL-DIFFERENTIATED CELLS  
Methods are disclosed for isolation of a stem-cell derived differentiated cell, which method entails illuminating an incident light onto a plurality of stem-cell derived cells that comprise at...
US20180334498 ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS  
The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the...
US20180334497 ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS  
The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the...
US20180334482 IN VITRO ASSEMBLY OF BACTERIAL MICROCOMPARTMENTS  
The present disclosure is related to a BMC fusion protein that is capable of in vitro assembly, comprising a constituent BMC shell protein subunit and a sterically hindering protein domain that is...
US20180334431 DEOXYURIDINE TRIPHOSPHATASE INHIBITORS  
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
US20180333394 COMPOSITIONS AND METHODS EMPLOYING WOLBACHIA FTSZ AS A TARGET FOR ALBENDAZOLE SULFONE  
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.
US20180333390 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT  
The present disclosure provides compositions including a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g.,...
US20180333249 DEGRADABLE INTESTINAL ANCHOR  
An organ lengthening device comprising a spring-like structure, wherein the surface of the device is covered with micron-size anchors such as hooks, studs or wires made from a biodegradable...
10134585 Low temperature atomic layer deposition of oxides on compound semiconductors  
Surface pretreatment of SiGe or Ge surfaces prior to gate oxide deposition cleans the SiGe or Ge surface to provide a hydrogen terminated surface or a sulfur passivated (or S—H) surface. Atomic...
10134127 Method for post-processing flow-sensitive phase contrast magnetic resonance images  
A method for generating fluid flow images of a region of interest is disclosed. The method includes: scanning the region of interest to acquire a set of 4D-Flow magnetic resonance images, wherein...
10132902 Intrinsic navigation from velocity-encoding gradients in phase-contrast MRI  
A method for an object in a magnetic resonance image (MRI) system for providing at least one velocity indicative magnetic resonance image (MRI) with motion correction of the object is provided....
10132811 Salivary transcriptomic and microbial biomarkers for pancreatic cancer  
The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing...
10132807 Bioassay for the early detection of autoimmune diseases  
Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that...
10132251 Fuel sensor for a variable-blend natural gas appliance using the Wobbe Index  
A system and method for configuring parameters for a variable gaseous appliance, comprise a sensor for detecting a composition of the gaseous fuel in a fuel tank. A first set of instructions are...
10131944 Molecular adapter for capture and manipulation of transfer RNA  
The invention also encompasses novel structures and methods comprising providing a molecular adapter for capture and manipulation of transfer RNA. The adaptor is bound to a tRNA molecule. The...
10131903 Microfluidic platform for synthetic biology applications  
This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate...
10131880 Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications  
Methods for the efficient isolation and use of pluripotent adipose-derived stem cells (PASCs) are provided. In certain embodiments the methods involve providing an adipose tissue sample from which...
10131838 Compositions for cooling materials exposed to the sun  
The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment...
10131668 Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1  
Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1 using for example, substituted imidazopyrazine compounds.
10131658 Anti-alphavbeta1 integrin compounds and methods  
Provided herein, inter alia, are methods and compositions for inhibiting αvβ1 integrin and for treating fibrosis.
10131599 Fracking with CO2 for shale gas reforming to methanol  
A method of producing methanol from shale gas and CO2 by the exclusive dry CO2 fracking of shale rock by injection of gaseous CO2 at a pressure between 10 and 100 atm to extract shale gas and...
10131585 Hopanoids producing bacteria and related biofertilizers, compositions, methods and systems  
Hopanoids, hopanoids-producing nitrogen-fixing bacteria, and related formulations, systems and methods are described herein. In particular, hopanoids alone or in combination with...
10130723 TCO conjugates and methods for delivery of therapeutic agents  
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being...
10130711 Chemical structures for localized delivery of therapeutic agents  
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being...
10130388 Position guidance device with bubble level  
A position guidance system for minimally invasive medical procedures includes a medical device having a first end configured for percutaneous insertion and a second end configured to remain...
10130253 Scanning laser ophthalmoscope for real-time eye tracking and method of operating same  
A scanning laser ophthalmoscope and a method of operating a scanning laser ophthalmoscope are disclosed. The scanning laser ophthalmoscope includes a light source, a reflective optical system, an...
US20180331360 LITHIUM-EXCESS CATHODE MATERIAL AND CO-PRECIPITATION FORMATION METHOD  
A lithium-excess cathode material according to Li1+xNiaMnbCocModO2−y (0
US20180329006 DIFFUSION-RELAXATION CORRELATION SPECTROSCOPIC IMAGING  
A method for identifying and spatially mapping microenvironments using coarse-resolution correlation spectroscopic imaging includes acquiring, using a magnetic resonance imaging (MRI) scanner,...
US20180328921 FORMATION AND USE OF EMBEDDED SOLUTIONS IN NANOSCALE MATERIALS  
Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded...
US20180327778 ANIMAL MODELS FOR BRAIN INFLAMMATION AND WHITE MATTER DEGENERATION  
Provided are methods of making and using animal models for brain inflammation and white matter degeneration.
US20180327733 MONOTERPENE-PRODUCING GENETICALLY MODIFIED HOST CELLS AND METHODS OF USE OF SAME  
The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).
US20180327373 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME  
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced...
US20180327369 CFTR REGULATORS AND METHODS OF USE THEREOF  
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.
US20180327280 Methods and Compositions for Removing Fluoride from Water  
The present invention provides for a system for removing a fluoride ion from an aqueous solution, comprising: (a) an aqueous solution comprising a fluoride ion, and (b) a bauxite mineral; wherein...
US20180326577 MODULAR ROD-CENTERED, DISTRIBUTED ACTUATION AND CONTROL ARCHITECTURE FOR SPHERICAL TENSEGRITY ROBOTS  
According to some embodiments of the invention, a tensegrity robot includes a plurality of compressive members, and a plurality of tensile members connected to the compressive members to form a...
US20180326550 ACOUSTIC AND VIBRATION SENSING APPARATUS AND METHOD FOR MONITORING CUTTING TOOL OPERATION  
A universal manufacturing vise jaw plate for use on a machine tool with a vise fixture, and configured for real-time operational data collection and analysis. The vise plate comprises a...
US20180326498 METHODS TO PRODUCE ULTRA-THIN METAL NANOWIRES FOR TRANSPARENT CONDUCTORS  
The disclosure provides methods to produce ultrathin metal nanowires, the metal nanowires produced therefrom, and the use of the metal nanowires as transparent conductors.
US20180326397 ZEOLITIC IMIDAZOLATE FRAMEWORKS  
The disclosure provides for multivariant zeolitic imidazolate frameworks (ZIFs), methods of making thereof, and methods of use therefrom.
US20180326117 High Yield and High Precision Bone Graft Substitute from Stem Cells  
The invention comprises various materials and methods for the formation of bone within a patient using implanted bodies that are seeded with bone forming cells. The implants of the invention may...
US20180326033 CODON-OPTIMIZED LENTIVIRAL VECTOR FOR STEM CELL REPROGRAMMING  
The invention relates to methods and materials that can be used to product cytotoxic T cells that target cancer cells expressing the cancer-testis antigen NY ESO-1. Illustrative embodiments of the...
US20180325999 POLYPEPTIDE-POLYMER CONJUGATES AND METHODS OF USE THEREOF  
The present invention provides polypeptide-polymer conjugates. A subject polypeptide-polymer conjugate is useful in a variety of applications, which are also provided.
US20180325860 Stable Analogs of CYP450 Lipid Metabolites and Inhibitors of Soluble Epoxide Hydrolase  
This disclosure relates to methods of reducing inflammation, angiogenesis, vascular leakage and neovascularization by administering to a subject in need thereof one or more stable analogs of...
US20180325448 ARTERY MAPPER  
An artery mapper is attached over a target artery, and includes a sensor array that detects pressure changes corresponding to pulsatile flow through the artery. The signals from the sensor array...
US20180325412 Methods for Biomedical Targeting and Delivery and Devices and Systems for Practicing the Same  
The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging...
US20180325389 ASSESSING ENDOTHELIAL FUNCTION AND PROVIDING CALIBRATED UFMD DATA USING A BLOOD PRESSURE CUFF  
Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine...
US20180325373 Implantable Extracompartmental Pressure Sensor  
A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with...
10129022 Secret key for wireless communication in cyber-physical automotive systems  
A key generation technique exploiting the randomness of a wireless channel to generate secret keys to secure automotive wireless communication using symmetric cryptography is presented. Moreover,...
10128450 Organic electroluminescent materials and devices  
A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X1 and X2 are selected from alkyl, cycloalkyl, alkoxy,...
10128441 Field-effect transistors based on macroscopically oriented polymers  
Embodiments of the invention include methods and materials for preparing organic semiconducting layers, for example one used in an organic semiconductor device including a substrate with a...