Patents and Patent Applications from University of California System


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US20180251730 COMPOSITIONS AND METHODS FOR GENERATING OLIGODENDROCYTE PRECURSORS  
The present disclosure provides a three-dimensional culture system comprising a biocompatible polymer and a combination of factors in an amount effective to induce differentiation of...
US20180251495 Skin-Penetrating Peptides and Compositions and Methods of Use Thereof  
Skin penetrating polypeptide and pharmaceutical compositions and methods of use thereof are provided. Typically, the peptides are between 3 and 100 amino acids, more preferably about 5, 6, 7, 8,...
US20180249925 LEAKAGE CORRECTION FOR DSC-PERFUSION MRI BY ACCOUNTING FOR BIDIRECTIONAL CONTRAST AGENT EXCHANGE  
A post-processing leakage correction system and method that accounts for bidirectional contrast agent transport between the intravascular and interstitial spaces that commonly occurs in angiogenic...
US20180249772 TRANSFORMABLE CLOTHING  
A transformable garment that folds and envelops the wearer with a garment body with panels that use origami folding and shape memory alloy (SMA) elements to assist to transform the garment from an...
10069095 Organic photosensitive devices with exciton-blocking charge carrier filters  
Disclosed herein are organic photosensitive devices including at least one exciton-blocking charge carrier filter. The filters comprise a mixture of at least one wide energy gap material and at...
10067119 Method for analyzing droplets  
A method for analyzing droplets is described. The droplets can be received on an outer surface region of a sampler surface disposed on a substrate, wherein the sampler surface is increasingly less...
10067031 Optical frequency measurement and control using dual optical-frequency combs  
A dual-comb optical-frequency comb generator includes a tunable comb-generating laser, a coarse-comb generator, a fine-comb generator, a second harmonic generator, a coarse-comb offset...
10066413 Automated construction of towers and columns  
A robot may extrude a tower or column. The robot may include an extrusion nozzle, a positioning system, a climbing apparatus, and a controller. The extrusion nozzle may controllably extrude...
10066223 Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea  
The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic...
10065985 Method for fully automated synthesis of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT)  
The automated synthesis of clinically relevant amounts of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes...
10065520 System for optimizing electricity use from an electric grid and related method  
A method of optimizing electricity use from an electric grid is disclosed. The method includes formulating a target load using a cost function for the electric grid, broadcasting a cost signal to...
10065322 Actively controlled microarchitectures with programmable bulk material properties  
A microarchitectured material having a plurality of interconnected unit cells in 2D or 3D configurations. The permanent interconnections to adjacent unit cells include mechanical output structures...
10064958 Nipah virus envelope pseudotyped lentiviruses and methods of their use  
The present invention relates to lentiviral particles which have been pseudotyped with Nipah virus (NiV) fusion (F) and attachment (G) glycoproteins (NiVpp-F/G). Additionally, the present...
10064914 Mitochondrial-derived peptide MOTS3 regulates metabolism and cell survival  
MOTS3 is a novel polypeptide. Methods of treating diseases such as diabetes, obesity, fatty liver, and cancer using MOTS3 and pharmaceutical compositions thereof are disclosed herein.
10064565 Multielectrode array and method of fabrication  
A multielectrode array with a fluidic channel and its method of fabrication are presented here. In accordance with various embodiments, the present invention allows for scalability,...
US20180247805 SPECTROMETRY METHOD AND SPECTROMETER DEVICE  
A spectrometer device for analysis of aerosol particles, dusts, and other microparticles and/or nanoparticles includes an electrospray ionization source supplying a particle stream to an...
US20180247722 TRANSPARENT CONDUCTORS  
The disclosure provides for transparent conductors comprised of metal-reduced graphene oxide or graphene core-shell nanowires, process of preparation thereof, and methods of use thereof.
US20180247408 System and Method for Improved Medical Images  
A method for using machine learning to perform classification of anatomical coverage of images includes acquiring a series of medical images of a subject. The method also includes automatically,...
US20180246037 Apparatus and Methods for Fluorescence Imaging Using Radiofrequency-Multiplexed Excitation  
Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light...
US20180245152 METHODS FOR DETECTION OF RNASE ACTIVITY  
Provided are compositions and methods for detecting RNase activity.
US20180245101 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION  
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a...
US20180245100 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION  
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a...
US20180244859 THERMOREVERSIBLE POLYMERS AND METHODS OF USE THEREOF  
The present disclosure provides thermoreversible polymers, hydrogel compositions comprising the thermoreversible polymers, as well as methods of making and using the thermoreversible polymers.
US20180244653 SELECTIVE ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM  
In alternative embodiments, provided are selective agonists having a high affinity for the alpha7 nicotinic acetylcholine receptor (α7 nAChR), assays for selectivity of nicotinic receptor subtype...
US20180244643 HIGHLY SENSITIVE DETECTION OF BIOMOLECULES USING PROXIMITY INDUCED BIOORTHOGONAL REACTIONS  
There provided, inter alia, reagents and methods for modulation fluorescence of a tetrazine containing compound and/or a dienophile-containing compound. There is provided a method of detecting...
US20180244638 SMALL MOLECULES THAT ENABLE CARTILAGE REJUVENATION  
There are provided, inter alia, methods and compounds for activating a proliferative program in competent adult chondrocytes.
US20180243924 TACTILE SENSORS AND METHODS OF FABRICATING TACTILE SENSORS  
Embodiments of the present disclosure describe a tactile sensor comprising an elastomeric membrane having a channel formed therein, a liquid conductive material located in the channel, and...
US20180243740 RECONFIGURABLE MICROVALVE OPTICAL WAVEGUIDE  
An optical waveguide comprises multiple layers of solid-state material disposed on a substrate. One of the layers is a lifting-gate valve made of a high refractive index material. The device...
US20180243447 ENGINEERED B LYMPHOCYTES AND COMPOSITIONS HAVING MICRO-RNA AND METHODS FOR MAKING AND USING THEM  
Provided are engineered B lymphocytes modified to express one or several different types of microRNAs or anti-miRs where in one embodiments the lymphocytes contain multiple copy numbers of nucleic...
US20180243442 POLY(VINYL ALCOHOL) NANOCARRIERS  
The present invention provides a nanoparticle including at least one polyvinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties...
US20180243249 METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS  
Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The...
US20180243245 LRH-1 MODULATORS  
Disclosed herein are compositions and methods for modulating the liver receptor homolog-1.
US20180243120 MODULAR SEMI-ACTIVE JOINT EXOSKELETON  
Systems, methods, and apparatus provide an artificial knee. Such artificial knees may include a thigh link configured to move in unison with a thigh of the person, a shank link configured to be...
PP29623 Peach tree named ‘Vilmos’  
A new peach variety (Prunus persica) designated as ‘Vilmos’ is provided. ‘Vilmos’ forms attractive, high quality fruit that matures during the commercially important ‘Andross’ period, and...
10061085 Silicon-photonics-based optical switch  
An optical switching system comprising a switching cell having first and second fixed-position bus waveguides and a moveable shunt waveguide is disclosed. The first bus waveguide includes an input...
10060875 Metal and metal oxide co-functional single-walled carbon nanotubes for high performance gas sensors  
A method of co-functionalizing single-walled carbon nanotubes for gas sensors, which includes the steps of: fabricating single-walled carbon nanotube interconnects; synthesizing tin oxide onto the...
10059988 Methods for using a nanopore  
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods...
10059984 Salt-tolerant DNA polymerases  
Four novel sequences of type B DNA polymerases and variants and analogues thereof useful for applications involving DNA polymerization in high salt conditions.
10058855 Redox-active metal-organic frameworks for the catalytic oxidation of hydrocarbons  
The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of redox-active metals or metal ions that are linked together by a plurality of...
10058704 Systems, devices and methods for the treatment of neurological disorders and conditions  
The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other...
10058572 Placenta-derived multipotent stem cells  
This disclosure provides isolated cells and compositions comprising one or more isolated cell(s) as described herein. In one aspect, the isolated cell is a pre-term placenta-derived stem cell...
10058561 Methods and related compositions for reduction of fat and skin tightening  
Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically active detergents are disclosed. The...
10058302 Method to reduce radiation dose in multidetector CT while maintaining image quality  
A method of reducing radiation dose for a selected organ on a patient in a computed tomography (CT) scan that uses an X-ray source to scan the patient. The method comprises a computer determining...
10058262 System and method of identifying sources for biological rhythms  
In a system and method of determining regularity associated with a rhythm disorder of a heart, a derivative of a first cardiac signal at a plurality of first time points is processed against a...
US20180242343 ELECTRONIC DEVICE AND METHOD FOR SCHEDULING  
A method for performing scheduling by a first base station over a wireless communication network, and an apparatus therefor are provided. The method includes receiving first channel status...
US20180241483 LOW POWER MAGNETIC FIELD BODY AREA NETWORK  
The invention provides a body area network that uses a near magnetic field for communications. A first coil is configured to be worn on a body portion of a human. A transmitter drives the first...
US20180241039 REGENERATIVE POLYSULFIDE-SCAVENGING LAYERS ENABLING LITHIUM-SULFUR BATTERIES WITH HIGH ENERGY DENSITY AND PROLONGED CYCLING LIFE AND METHODS OF MAKING SAME  
The invention relates to a method for fabricating a regenerative polysulfide-scavenging layer (RSL). The method includes embedding nanowires or nanocrystals of metal oxides with a membrane of...
US20180241035 MICROBATTERY  
Disclosed is a microbattery having a substrate with a surface that includes an array of posts extending from the surface of the substrate to form a first electrode. An selectively-cured...
US20180240972 GROUND STATE ARTIFICIAL SKYRMION LATTICES AT ROOM TEMPERATURE  
A method for fabricating artificial skyrmions and skyrmion lattices with a stable ground state at room temperature and in the absence of magnetic fields is provided. The lattices are formed by...
US20180240896 MAGNETO-ELECTRIC LOGIC DEVICES USING SEMICONDUCTOR CHANNEL WITH LARGE SPIN-ORBIT COUPLING  
Antiferromagnetic magneto-electric spin-orbit read (AFSOR) logic devices are presented. The devices include a voltage-controlled magnetoelectric (ME) layer that switches polarization in response...