Patents and Patent Applications from University of California System


Match Document Document Title
US20180112002 MODULATORS OF ROR1-ROR2 BINDING  
Provided herein are, inter alia, methods of identifying agents that are capable inhibiting the binding (e.g., coupling) between a ROR1 protein and a ROR2 protein. By interfering with ROR1-ROR2...
US20180111955 THIOSACCHARIDE MUCOLYTIC AGENTS  
There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective...
US20180111263 METHOD AND APPARATUS FOR HUMAN ARM SUPPORTING EXOSKELETON  
An arm supporting exoskeleton comprises a shoulder base coupled to an arm link mechanism. The arm link mechanism comprises a proximal link and a distal link configured to rotate relative to each...
US20180111262 METHOD AND APPARATUS FOR HUMAN ARM SUPPORTING EXOSKELETON  
An arm supporting exoskeleton comprises a shoulder base coupled to an arm link mechanism. The arm link mechanism comprises a proximal link and a distal link configured to rotate relative to each...
US20180110866 POLYMERIC ANTIBIOTICS  
The disclosure provides, inter alia, polymeric antibiotic compounds such as modified chitosans and methods of use thereof.
US20180110784 SYNTHETIC TLR4 AND TLR7 LIGANDS TO PREVENT, INHIBIT OR TREAT LIVER DISEASE  
Methods of using TLR7 conjugates or TLR4 ligands, or a combination thereof, to treat fibrosis are provided.
US20180110757 METHODS OF TREATING PRURITIS AND PAIN  
The present disclosure provides compositions and methods for treating pruritis and for treating certain types of pain.
US20180110727 CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS  
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal,...
US20180110632 MECHANISM FOR EFFICIENT DONNING AND DOFFING OF AN EXOSKELETON  
A manual apparatus of the present disclosure enables quick connection and disconnection of an exoskeleton leg from a remaining body of an exoskeleton. The apparatus comprises a cavity defined by a...
US20180110492 ENCAPSULATED GAS OR PARTIAL VACUUM CONTRAST MATERIAL  
The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium...
9953246 Feature-preserving noise removal  
A noise removal method includes receiving in a de-noising system multiple noisy copies of a target image; providing the noisy copies as input data to the de-noising system in a training phase, and...
9952453 Broadband metacoaxial optical nanoantennas based on plasmonic modes  
Techniques, systems, and devices are disclosed for implementing nanostructures in the optical domain that highly localize the incident electromagnetic field to with a large spectral range from the...
9952216 Brain-specific enhancers for cell-based therapy  
Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to...
9951912 Tunable white light based on polarization sensitive light-emitting diodes  
A lighting apparatus for emitting polarized white light, which includes at least a first light source for emitting primary light comprised of one or more first wavelengths and having a first...
9951354 Production of β-phellandrene using genetically engineered cyanobacteria  
The present invention provides methods and compositions for producing β-phellandrene hydrocarbons from cyanobacteria.
9951345 Host cells and methods for producing diacid compounds  
The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more...
9951118 Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors  
The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling HIV replication and is an important part of the ultimate failure to eradicate the virus. Disclosed...
9951107 Vault complexes  
The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to...
9951097 Antibacterial compounds targeting isoprenoid biosynthesis  
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by...
9950715 Air-coupled ultrasonic inspection of rails  
In some example implementations, there is provided a method. The method may include generating, by an air-coupled transducer, a first ultrasonic guided wave to cause the generated ultrasonic...
9950341 Systems and methods for fabricating spiral coils with atomized bioactive coatings  
Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via...
9950001 Polynucleotides having bioreversible groups  
The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge-neutralizing...
9949927 Bis-polymer lipid-peptide conjugates and nanoparticles thereof  
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can...
US20180109339 SYSTEM AND METHOD OF OCCUPANCY ESTIMATION UTILIZING TRANSMITTED SIGNALS  
A method estimating number of occupants in a region includes receiving at one or more receiving unit a signal or signals transmitted from one or more transmitting units, wherein the transmitting...
US20180108964 INTEGRATED ANTENNAS AND PHASED ARRAYS WITH MODE-FREE ELECTROMAGNETIC BANDGAP MATERIALS  
A multifunctional electromagnetic structure is presently disclosed. Said structure is a true electromagnetic bandgap (“EBG”) material, with both surface and leaky waves suppressed from the whole...
US20180108510 STABLE SUPPORT FILMS FOR ELECTRON MICROSCOPY  
This disclosure provides systems, methods, and apparatus related to arrangements including electron microscopy grids. In one aspect an arrangement includes an electron microscopy grid. The...
US20180106729 IMAGING PLATFORM BASED ON NONLINEAR OPTICAL MICROSCOPY FOR RAPID SCANNING LARGE AREAS OF TISSUE  
A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm2 (without stitching adjacent FOVs) at speeds of 10 frames/second...
US20180106724 OPTICAL SENSING WITH CRITICALLY COUPLED PLANAR WAVEGUIDE WITH OPTIONAL INTEGRATION OF LAYERED TWO-DIMENSIONAL MATERIALS  
An optical sensing system includes a planar optical waveguide having a first surface for detection and a second surface for coupling light. The optical sensing system includes a functional layer...
US20180105802 Viral Targeting with Knottins  
The use of targeting knottin polypeptides provides a means of selectively infecting target cells presenting species bound by the knottins. The targeted viruses may be used as cytotoxic agents, for...
US20180105743 HETEROJUNCTIONS IN HALIDE PEROVSKITE NANOSTRUCTURES  
This disclosure provides systems, methods, and apparatus related to heterojunctions in halide perovskite nanostructures. In one aspect, a nanostructure comprises a first region and a second...
US20180105565 Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
US20180105553 POLYPEPTIDES, PEPTIDES, AND PROTEINS FUNCTIONALIZED BY ALKYLATION OF THIOETHER GROUPS VIA RING-OPENING REACTIONS  
Some embodiments of the invention involve methods for introduction of various functional groups onto polypeptides, peptides and proteins by alkylation of thioether (a.k.a. sulfide) groups by ring...
US20180105441 DEVICES AND METHODS FOR REMOVING DISSOLVED IONS FROM WATER USING COMPOSITE RESIN ELECTRODES  
The present disclosure provides a device comprising or configured to comprise composite resin electrodes. Further provided are methods of using the device for selectively removing dissolved ions...
US20180104307 Targeting GIV-GEF-GI Signaling for Treating Diverse Diseases  
The invention provides cell-permeable Ga-Interacting Vesicle associated protein (GIV)-derived peptides and their use for treatment of diverse diseases. The invention further provides C-terminus of...
US20180104281 HIGH TELMERASE ACTIVITY BONE MARROW MESENCHYMAL STEM CELLS, METHODS OF PRODUCING THE SAME AND PHARMACEUTICALS AND TREATMENT METHODS BASED THEREON  
Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34+ bone marrow mesenchymal stem cells. Also...
US20180103921 METHOD FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING ANALYSIS FOR CLASSIFYING AND DIAGNOSING OF NEUROLOGICAL DISEASES  
A method of using PET imaging includes using PET images obtained using a radiotracer for the determination of the progressive course of regional brain PET activities for a progressive...
9946475 Joint rewriting and error correction in write-once memories  
Both rewriting and error correction are technologies usable for non-volatile memories, such as flash memories. A coding scheme is disclosed herein that combines rewriting and error correction for...
9945864 Disease-associated antigens and methods of use thereof  
The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides...
9945802 High throughput label free nanoparticle detection and size assay  
The present invention reports a novel microfluidic analyzer for the high-throughput, label-free measurement of particles suspended in a fluid. The present invention employs the resistive pulse...
9944982 Surface chemistry and deposition techniques  
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface...
9944967 Methods for the site-selective introduction of halogen into natural products  
Organohalides (e.g., organofluorides) represent a rapidly expanding proportion of molecules used in pharmaceuticals, diagnostics, agrochemicals, and materials. The present invention exploits the...
9944675 Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same  
Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that...
9944583 Methods for ameliorating and preventing central nervous system inflammation  
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated...
9943996 Process planning of meniscus shapes for fabricating smooth surfaces in mask image projection based additive manufacturing  
A system may produce a desired three dimensional object that includes a tank that holds a liquid that solidifies upon exposure to light; a controllable stage that controllably moves within the...
9943509 Methods, compounds, and compositions for the treatment of musculoskeletal diseases  
This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy,...
US20180102749 ULTRA-BROADBAND TRANSIMPEDANCE AMPLIFIERS (TIA) FOR OPTICAL FIBER COMMUNICATIONS  
Design of ultra broadband transimpedance amplifiers (TIA) for optical fiber communications is disclosed. In one embodiment, a TIA comprises a gm-boosted dual-feedback common-base stage, a level...
US20180101643 Systems and Methods for Predicting Glycosylation on Proteins  
The disclosed technology provides a computational prediction modeling comprising a novel algorithm for prediction of glycosylation or to optimize biopharmaceutical production of proteins of...
US20180100862 Highly Sensitive System and Methods for Analysis of Troponin  
The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis,...
US20180100854 METHODS AND DEVICES FOR INTEGRATING ANALYTE EXTRACTION, CONCENTRATION AND DETECTION  
Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a...
US20180100818 ICE NUCLEATING PARTICLE SPECTROMETER  
Methods, systems, and devices are disclosed for implementing an exemplary immersion mode ice spectrometer. In order to increase sample throughput and improve accuracy of Ice Nucleating Particle...