Patents and Patent Applications from University of California System


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9901648 Stabilization of biomolecules using sugar polymers  
Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to...
9901285 Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue  
NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue...
US20180053626 ION BEAM MILL ETCH DEPTH MONITORING WITH NANOMETER-SCALE RESOLUTION  
A method for measuring conductance of a material real-time during etching/milling includes providing a fixture having a socket for receiving the material. The socket is attached to a printed...
US20180052425 DEVICE AND METHOD FOR NANOPARTICLE SIZING BASED ON TIME-RESOLVED ON-CHIP MICROSCOPY  
A method for the label-free sizing of small, nanometer-sized objects such as particles includes a hand-held, portable holographic microscope that incorporates vapor condensation of nanolenses and...
US20180052155 Assay Devices and Methods  
An assay device including a loading zone for a sample that may contain an analyte, an activator in communication with the loading zone from which at least one activator is displaced by presence of...
US20180052137 Cephalopod Proteins as Proton Conductors  
The disclosed invention relates to novel materials and associated methods for conducting protons, such materials comprising cephalopod proton-conducting proteins such as reflectins. The protonic...
US20180051347 METHODS FOR IMMUNOTHERAPY-BASED TREATMENT AND ASSESSMENT OF CANCER  
Disclosed herein are methods of treating or assessing cancer in a subject wherein it has been determined whether the cancer comprises a loss of function mutation or disruption in an immune...
US20180051320 DEPLETION OF ABUNDANT SEQUENCES BY HYBRIDIZATION (DASH)  
Among other things, this disclosure describes a method comprising: cleaving a plurality of target sequences in an adaptor-tagged sequencing library using population of reprogrammed nucleic...
US20180051316 DETECTION OF NUCLEIC ACID POLYMERASE CONFORMATIONAL CHANGES USING A NANOTUBE  
The invention provides methods and compositions for detecting a change in a nucleic acid polymerase conformation involving contacting a nucleic acid polymerase non-covalently attached to a single...
US20180051253 METHODS OF PREVENTING AND REVERSING STEM CELL AGING  
Methods of preventing and reversing stem cell aging including the step of activating the mitochondrial unfolded protein response in a stem cell are described. Further described are methods of...
US20180050932 Methods of Removing Perchlorate from Water and Vessels and Systems for Practicing the Same  
Provided are methods of removing perchlorate from water. The methods include contacting water suspected of containing perchlorate with a cationic material. The cationic material includes one or...
US20180050500 SYSTEMS AND METHODS FOR ADDITIVE MANUFACTURING TO ENCAPSULATE TRANSFORMATIVE COLLOIDAL SUSPENSIONS  
The present disclosure relates to a method of forming an energy absorbing three dimensional (3D) structure. The method involves forming an outer shell for the 3D structure from a shell material,...
US20180049853 ULTRASONIC SCALER WITH LASER THERAPY CAPABILITY  
An ultrasonic device with laser therapy capability, and more particularly, but not exclusively, to ultrasonic scaler with laser therapy capability.
US20180049411 GENERATION OF AN INDUCIBLE PERICYTE-SPECIFIC CRE MOUSE MODEL  
Pericytes are mural cells of brain capillaries that degenerate in multiple neurological disorders. Pericytes regulate neurovascular functions, but their role in the adult brain and disease is...
US20180049364 PRECISION CROP PRODUCTION-FUNCTION MODELS  
Systems, apparatuses, and methods as described herein relate to analyzing plant nutrient-yield relationships and identifying optimum plant fertilization strategies to improve individual plant...
9899693 Microstructured cathode for self-regulated oxygen generation and consumption  
A fuel cell is disclosed with a self-regulated oxygen supply used in conjunction with a self-pumping fuel supply (e.g., a self-pumping anode). The cathode side of the fuel cell includes a gas...
9899450 Memristors and method for fabricating memristors  
There are disclosed memristors and memristor fabrication methods. A memristor may include a stack of four functional elements including, in sequence, a first electrode, a barrier layer, an...
9897592 Methods for identifying arthropod repellents and attractants, and compounds and compositions identified by such methods  
Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided...
9897532 Method and device for high throughput cell deformability measurements  
A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow...
9896725 Real-time, label-free detection of macromolecules in droplets based on electrical measurements  
A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in...
9896700 Engineered recombinant enzymes for methane oxidation  
Provided herein are soluble engineered polypeptides for oxidizing hydrocarbons, and methods of use, manufacture, and design thereof. In particular, soluble, polypeptides capable of oxidizing...
9896532 Deactivation of urushiol and method of treatment and prevention of contact dermatitis  
The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to...
9896481 Modified mini-hepcidin peptides and methods of using thereof  
Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.
9896437 Diarylhydantoin compounds  
The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
9895454 Metal oxide catalyzed radiofluorination  
Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent...
9895433 Interferon-β production modulating listeria strains and methods for using same  
Mutant Listeria bacteria that modulate interferon-β production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR...
9895396 Citrate containing beverage  
Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may...
9895373 Substituted pyrazolo[3,4-D]pyrimidines and uses thereof  
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
9895104 Method and device for reference point indentation without a reference probe  
The device performs reference point indentation without a reference probe. The indentation distance is measured relative to the instrument which remains substantially stationary during the impact...
US20180048811 PATTERNED-ILLUMINATION SYSTEMS ADOPTING A COMPUTATIONAL ILLUMINATION  
A method and apparatus for increasing sample image resolution using patterned illumination. An array of optical emitters is selectively activated as a programmable light source, directed to a...
US20180048187 FLUX-ENHANCED ENERGY HARVESTING FROM CURRENT-CARRYING CONDUCTORS  
An apparatus for harvesting power from a current carrying conductor without electrically contacting the conductor is provided. The apparatus employs a coil with core and flux concentrators of high...
US20180047985 SOLVATED GRAPHENE FRAMEWORKS AS HIGH-PERFORMANCE ANODES FOR LITHIUM-ION BATTERIES  
A lithium-ion battery includes: 1) an anode; 2) a cathode; and 3) an electrolyte disposed between the anode and the cathode and including lithium ions. The anode includes a graphene framework film...
US20180047887 Multi-stage thermoelectric generator monolithically integrated on a light absorber  
A solar-powered thermoelectric generator is provided that includes a solar collector, a light absorbing and heat generating element having an elongated shape, where a first end of the light...
US20180047520 FABRICATION OF ENHANCED SUPERCAPACITORS USING ATOMIC LAYER DEPOSITION OF METAL OXIDE ON NANOSTRUCTURES  
A method to a fabricate high surface area, high performance supercapacitor includes include applying a metal layer to at least a portion of a nanostructure; after applying the metal layer,...
US20180046752 PATHWAY RECOGNITION ALGORITHM USING DATA INTEGRATION ON GENOMIC MODELS (PARADIGM)  
The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
US20180046751 PATHWAY RECOGNITION ALGORITHM USING DATA INTEGRATION ON GENOMIC MODELS (PARADIGM)  
The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.
US20180045938 FILTER ARRAY BASED ULTRAFAST COMPRESSIVE IMAGE SENSOR  
An apparatus for compressive sensing may include a filter array, a detector, and a reconstruction engine. The filter array may be configured to generate a first illumination pattern in response to...
US20180045675 SINGLE-CELL INTRACELLULAR NANO-PH PROBES  
Disclosed is a method and device for sensing pH in a single living cell. The device is constructed for directing a nano-sized probe to pierce a single cell and extract accurate pH measurements in...
US20180045590 Mechanisms of local stress sensing in multifunctional polymer films using fluorescent tetrapod nanocrystals  
Nanoscale stress-sensing can be used across fields ranging from detection of incipient cracks in structural mechanics to monitoring forces in biological tissues. We demonstrate how tetrapod...
US20180044733 Circulatory MicroRNAs (miRNAs) as Biomarkers for Diabetic Retinopathy (DR) and Age-Related Macular Degeneration  
The present disclosure provides methods that find use in determining a likelihood of having or developing diabetic retinopathy (DR) in a subject. Such methods generally include detection of one or...
US20180044700 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION  
The present disclosure provides compositions and methods of site-specific modification of a target DNA, or a protein associated with a target DNA, in a eukaryotic cell. The present disclosure...
US20180044628 Method for Biofilm Control and Treatment  
The invention provides a novel method for controlling and/or treating the growth of biofilms by promoting growth of the periphery cells and/or increasing nutrient consumption by the periphery...
US20180044382 Electron Spin Labeled Ice Binding Compounds Used For Carrying Paramagnetic Centers For Dynamic Nuclear Polarization  
Spin-labeled ice binding compounds (IBCs) including ice binding proteins (IBPs) or antifreeze proteins (AFPs) and their analogs may carry paramagnetic centers for dynamic nuclear polarization...
US20180044278 COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF INFLAMMATORY, DEGENERATIVE, AND NEURODEGENERATIVE DISEASES  
This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative...
US20180043183 Radiotherapy Utilizing the Entire 4PI Solid Angle  
In various embodiments, methods and devices are provided for generating a radiotherapy treatment plan for a subject to be implemented on a radiotherapy device. In certain embodiments the methods...
US20180043083 Magnetic Filtration Devices and Methods Related Thereto  
In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.
US20180043058 MESH ENCLOSED TISSUE CONSTRUCTS  
A heart valve leaflet including a thermoplastic polyurethane (TPU) mesh material that has a stiffness that is comparable to a native heart valve leaflet, such that it functionally mimics a native...
US20180042993 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING DAMAGE TO THE HEART  
Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (MI) resulting from harmful fibrotic remodeling, thereby improving...
US20180042963 CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF  
The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure...
US20180042900 Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone  
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.