Patents and Patent Applications from University of California System


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US20180201958 GLUCOSE METABOLISM WITH MOLECULAR PURGE VALVE  
Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.
US20180201681 ANTI-CD83 ANTIBODIES AND USE THEREOF  
The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.
US20180201655 ALLOPHYCOCYANIN ALPHA-SUBUNIT EVOLVED LABELING PROTEINS (smURFPs)  
The invention provides evolved red-shifted smURFPs. In some embodiments, the smURFPs are characterized by a) increased Fluorescence of smURFP as compared to infrared FPs IFP1.4 and iRFP713; b)...
US20180201627 ORGANOBORON COMPOUNDS AND METHODS OF MAKING ORGANOBORON COMPOUNDS  
Embodiments of the present disclosure provide for methods of making an organoboron compound, organoboron compounds, and the like.
US20180200947 SLA ADDITIVE MANUFACTURING USING FROZEN SUPPORTS OF NON-SLA MATERIAL  
Methods and apparatuses for additive manufacturing using stereolithography (“SLA”) materials. The apparatus includes a platform for holding an assembly of SLA resin layers. The apparatus also...
US20180200717 Devices for Separating Constituents in a Sample and Methods for Use Thereof  
Devices for separating constituents (e.g., cells) in a fluid sample are provided. The device includes a microfluidic conduit configured to carry a flow of a fluid sample and includes two or more...
US20180200677 HEMOLYSIS-FREE BLOOD PLASMA SEPARATION  
A simple and robust on-chip blood plasma separation device is provided. The device is configured to integrate with downstream detection modules and provides sample-to-answer microfluidic POC...
US20180200526 IMPLANTABLE ANTENNA FOR PHYSIOLOGICAL MONITORING OR STIMULATION OF TISSUE  
An antenna for use in living tissue and designed to at least one of receive or transmit signals includes a conductive ground plane. The antenna further includes a first conductive patch having at...
US20180200312 Methods and Compositions for Enhancing Memory and/or Reducing Fear and/or Pain of a Host by Administering a Probiotic  
The present invention provides for a probiotic composition designed to enhance memory and/or reduce fear and/or pain of a host, the probiotic composition comprising viable or live cells of one or...
US20180200244 METHODS OF IMPROVING CELL-BASED THERAPY  
Provided are methods for improving cell-based therapies by co-administration with an agent that increases the production and or levels of epoxygenated fatty acids, as well as kits, stents and...
US20180200151 ENTERAL FAST ACCESS TRACT PLATFORM SYSTEM  
A gastrointestinal administration device comprising an elongated tube or track, an anchor and a channel, which allows the proximal end of the tube or track to be wholly secured inside the mouth...
US20180200135 EXOSKELETON LEGS TO REDUCE FATIGUE DURING REPETITIVE AND PROLONGED SQUATTING  
A leg support exoskeleton is strapped on as a wearable device to support its user during squatting and/or lunging. The exoskeleton includes a knee joint connected to a first link and a second...
US20180199613 AUTOMATED STRAWBERRY ORIENTING AND CAPPING MACHINE  
An automated apparatus for removing the tops (calyx) of strawberries as they move along a conveyor belt having a plurality of concave-shaped slotted rollers which operate to orient the calyx of...
10027362 Wireless wearable big data brain machine interface  
A wireless wearable high data throughput (big data) brain machine interface apparatus is presented. An implanted recording and transmitting module collects neural data from a plurality of...
10027306 Non-reciprocal, tunable notch amplifying RF front-ends based on distributedly modulated capacitors (DMC)  
A tunable notch filter/amplifier based on the non-reciprocal operation of distributedly modulated capacitors (DMC) formed for an RF front end. In one embodiment within the DMC is formed into a...
10026899 Active materials for electro-optic devices and electro-optic devices  
Tandem electro-optic devices and active materials for electro-optic devices are disclosed. Tandem devices include p-type and n-type layers between the active layers, which are doped to achieve...
10026338 Embedded motion sensing technology for integration within commercial ultrasound probes  
An ultrasound system including an ultrasound machine and an ultrasound probe. The ultrasound probe includes an ultrasound transducer, ultrasound circuitry, a six degree of freedom (6-DOF) sensor,...
10025952 Obfuscation of sensitive human-perceptual output  
The present invention includes a system and method for defending against unwanted observations of the information conveyed by electronic devices. The system allows users to access sensitive...
10024858 Portable blood count monitor  
This disclosure describes the development of a sample preparation, measurement, and analysis method that permits accurate characterization of red blood cells, platelets, and white blood cells,...
10024819 Microfluidics with wirelessly powered electronic circuits  
Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device...
10023903 Saliva collection, processing, stabilization, and storage method  
Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and...
10023588 Compositions and methods for treating cancer  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
10023581 Modified cytotoxins and their therapeutic use  
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or...
10022565 External beam radiotherapy and imaging with radioactive isotope  
A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body...
10022450 Regulation of specific spinal neurons regulating pain transmission via chimeric toxins  
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the...
10022097 Direct patlak estimation from list-mode PET data  
A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data...
US20180199161 RECEIVED SIGNAL STRENGTH TRANSFORMATION METHOD TO ACHIEVE BETTER INDOOR RADIO FREQUENCY LOCALIZATION  
A method for localizing a mobile device in a physical space based on radio signals received from transmitters in the physical space includes a step of transforming a received signal strength...
US20180198322 WIRELESS POWER TRANSFER DEVICE AND METHOD WITH DUAL-FREQUENCY OPERATION  
A method and device for wireless power transfer provide the ability for concurrent power transfer on two widely separated bands. A wireless power transmitting device includes two coils...
US20180196193 MICRO-PLATE READER FOR ELISA TESTING  
A micro-plate reader for use with a portable electronic device having a camera includes an opto-mechanical attachment configured to attach/detach to the portable electronic device and includes an...
US20180195229 SELF-CALIBRATING AUTOMATIC CONTROLLER TO DETERMINE END OF CYCLE AND TRACK DRYER CYCLE EFFICIENCY  
An apparatus and method for controlling the drying cycle in a clothes dryer. The dryer controller measures differences between air inlet temperature and temperature of an air outlet, drum, and/or...
US20180195205 Hierarchically Controlled Inside-Out Doping of Mg Nanocomposites for Moderate Temperature Hydrogen Storage  
A nickel-doped Mg nanocrystals encapsulated by molecular-sieving reduced graphene oxide (rGO) layers is disclosed. Dual-channel doping, which combines external (rGO strain) and internal (Ni...
US20180195126 COMPOSITIONS AND METHODS FOR DETERMINING GENETIC POLYMORPHISMS IN THE TMEM216 GENE  
In alternative embodiments, the invention provides nucleic acid sequences that are genetic polymorphic variations of the human TMEM216 gene, and TMEM216 polypeptide encoded by these variant...
US20180194825 Combination Immunotherapy  
The invention is based on the disclosure provided herein that secondary lymphoid organ chemokine (SLC) inhibits the growth of syngeneic tumors in vivo. Thus, the invention provides a method of...
US20180194807 ANTIGENIC PEPTIDES AND USES THEREOF FOR DIAGNOSING AND TREATING AUTISM  
The present invention provides peptides that specifically bind to maternal autoantibodies that are generated in the mother or potential mother against one or more endogenous polypeptide antigens...
US20180194740 DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE  
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
US20180194722 INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME WITH IMPROVED ORAL BIOAVAILABILITY AND THEIR USE AS MEDICAMENTS  
Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
US20180194064 SURFACE PROJECTION TOOL FOR MULTI-AXIS ADDITIVE MANUFACTURING  
Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an...
US20180193836 MICROFLUIDIC IN SITU LABELLING ON STABLE INTERFACES  
A method of trapping constituents of interest in a fluid sample flowing through a microfluidic channel by vibrating an interface of the fluid sample and a gas occupying a lateral channel adjacent...
US20180193357 ANTICONVULSANT ACTIVITY OF STEROIDS  
The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
US20180193295 GABA AGONISTS IN THE TREATMENT OF DISORDERS ASSOCIATED WITH METABOLIC SYNDROME AND GABA COMBINATIONS IN TREATMENT OR PROPHYLAXIS OF TYPE I DIABETES  
In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the...
US20180193268 FUSOGENIC LIPOSOME-COATED POROUS SILICON NANOPARTICLES  
The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic...
US20180192651 THERMAL VOLATILIZATION OF ORCO AGONISTS  
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting)...
10019516 System and method for fuzzy ontology matching and search across ontologies  
A computer implemented method of matching ontologies is disclosed. The method includes, for each pair of entities of a first ontology and a second ontology, wherein each pair of entities includes...
10017821 Biomarkers for diagnosing ischemia  
The present invention provides methods and compositions for diagnosing and predicting the occurrence of ischemia. For example, the present invention provides methods and compositions for...
10017757 Cellular libraries of peptide sequences (CLiPS) and methods of using the same  
The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and...
10017551 Peptides having reduced toxicity that stimulate cholesterol efflux  
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and...
10017528 Controlled synthesis of polymeric perylene diimide and applications thereof  
Perylene diimide phosphoramidite derivatives and methods for polymerization of perylene diimide phosphoramidite derivatives and applications thereof are provided. Compounds comprise at least an...
10016601 Pulse generator for cranial nerve stimulation  
A system for trigeminal nerve stimulation includes a pulse generator, which includes a user control configured to receive a user adjustment and a microcontroller configured to receive electric...
10016498 D-amino acid derivative-modified peptidoglycan and methods of use thereof  
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using...
10016490 Multiple-enzyme nanocomplexes  
Provided are nanocomplexes having at least two different enzymes and a polymeric network anchored to at least one of the enzymes. In some embodiments, the activities of the enzymes catalyze a...