Patents and Patent Applications from University of California System


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9910044 Methods for identifying arthropod repellents based on modulation of specific ionotropic receptors, and compounds and compositions identified by such methods  
Provided herein are screening methods for identifying arthropod repellent compounds based on modulation of ionotropic receptors, including an Ir40a receptor, an Ir93a receptor and an Ir25a...
9909985 Multiple superimposed interface pattern porous microstructure multi layer biosensing method  
A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest....
9909188 Methods and compositions involving lincRNA and leukemia  
The instant disclosure relates to the finding that lincRNA expression is associated with particular cytogenetic abnormalities and is related to disease pathogenesis of certain cancers. Long...
9909172 Non-thermal cycling for polymerase chain reaction  
Techniques, systems, and devices are disclosed for non-thermal cycling of polymerase chain reaction (PCR). In one aspect, a method for cycling PCR includes receiving an electrolytic fluid...
9909128 Splice modulating oligonucleotides that inhibit cancer  
A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit...
9909098 Methods of tissue-based diagnosis  
The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue...
9908848 Amide derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors  
Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein...
9907961 Artificial cardiac pacemaker device assembly  
The present invention provides a fully intrathoracic artificial pacemaker. The pacemaker is of sufficiently compact size to allow for implantation of both the electrode and the power source within...
9907958 High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury  
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal...
9907876 Switchable gas and liquid release and delivery devices, systems, and methods  
Methods, systems, and devices are disclosed for implementing switchable dispensing and/or delivery of scented substances. In one aspect, a device includes a cartridge structured to include one or...
9907856 Carboxymethylcellulose-peptide conjugates and methods for using the same  
Provided are compositions for repairing an injured tissue. The composition includes carboxymethylcellulose conjugated to an extracellular matrix derived peptide, and a methylcellulose. Also...
9907544 Minimally obstructive retractor for vaginal repairs  
This application presents minimally-obstructive and structurally-adjustable retractors for vaginal repairs, which afford an open work area of desirable size and enhanced visualization for a...
9907515 Health monitoring system  
A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous...
US20180062159 DEVICES COMPRISING CARBON-BASED MATERIAL AND FABRICATION THEREOF  
Energy storage devices are disclosed. In some embodiments, the energy storage devices comprise a positive electrode comprising a carbon-based material comprising porous carbon sheet(s)....
US20180061066 HIGH CONTENT SCREENING WORKFLOWS FOR MICROSCOPE IMAGING  
Disclosed herein are systems methods for high content screening for microscope imaging. In some embodiments, the system comprises: a microscope; and a processor configured to implement: a slide...
US20180059633 SYSTEM AND APPARATUS FOR AND METHODS OF CONTROL OF ENERGY USE IN A BUILDING  
This disclosure provides systems, methods, and apparatus related to energy management in a building. In one aspect, a method includes providing a plurality of apparatus. Each apparatus of the...
US20180059153 METHODS, SYSTEMS, AND DEVICES FOR IDENTIFYING COMPUTATIONAL OPERATIONS BASED ON POWER MEASUREMENTS  
Disclosed herein are methods, systems, and devices for identifying computational operations based on power measurements. Disclosed herein are systems that may include a phase measurement unit...
US20180059078 GENERATION AND ANALYSIS OF CHEMICAL COMPOUND LIBRARIES  
Various samples are generated on a substrate. The samples each includes or consists of one or more analytes. In some instances, the samples are generated through the use of gels or through vapor...
US20180059051 HIGH PERFORMANCE CHEMICAL AND BIO SENSORS USING METAL OXIDE SEMICONDUCTORS  
Electrochemical and bio sensors using metal oxide semiconductors and method of making the same are described herein. The sensor includes a gate electrode, a dielectric layer over the gate...
US20180057839 THERAPEUTIC COMPOSITIONS COMPRISING TRANSCRIPTION FACTORS AND METHODS OF MAKING AND USING THE SAME  
The present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected of having liver fibrosis. The...
US20180057805 IONIC LIQUID-TOLERANT CELLULASE ENZYMES  
The present invention provides ionic liquid-tolerant cellulases and method of producing and using such cellulases. The cellulases of the invention are useful in saccharification reactions using...
US20180057801 RED-SHIFTED LUCIFERASE-LUCIFERIN PAIRS FOR ENHANCED BIOLUMINESCENCE  
A bioluminescent protein is provided that includes a substituted luciferase polypeptide having amino acid substitutions at positions 21 and 166, and with one or more additional amino acid...
US20180057800 CHLAMYDOMONAS VIOLAXANTHIN DE-EPOXIDASE ENZYME AND ITS USES  
This disclosure provides Chlamydomonas violaxanthin de-epoxidase (CVDE) gene, polypeptides, and variants thereof as well as host cells that are genetically modified to express a CVDE polypeptide...
US20180057538 POTENT AND HIGHLY SOLUBLE PEGYLATED COMPSTATIN PEPTIDES  
The disclosure provides for highly soluble PEGylated compstatin peptides, which exhibit high binding affinities for complement and therapeutic efficacy in vitro. The disclosure further provides...
US20180057483 Novel RAD51 Inhibitors and Uses Thereof  
The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also...
US20180057417 Compositions and methods useful for enhancing the microbial conversion of nitrate into ammonium  
The present invention provides for methods of and compositions for enhancing microbial conversion of nitrate into ammonium. The methods and compositions alter the end products of microbial nitrate...
US20180056294 INTEGRATED SYSTEM FOR ISOLATION AND EMULSIFICATION OF PARTICLES AND CELLS  
A system for isolating and emulsifying particles or cells within droplets includes a microfluidic trapping device having an inlet and an outlet and one or more channels disposed between the inlet...
US20180056288 High Definition Microdroplet Printer  
Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of...
US20180055950 NEURONAL SPECIFIC TARGETING OF CAVEOLIN EXPRESSION TO RESTORE SYNAPTIC SIGNALING AND IMPROVE COGNITIVE FUNCTION IN THE NEURODEGENERATIVE BRAIN AND MOTOR FUNCTION IN SPINAL CORD  
The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding...
US20180055882 FUNCTIONAL IMMUNOPHENOTYPING OF LEUKOCYTES IN HUMAN TISSUES  
Methods of detecting surface markers on T-cells from skin samples are provided. T-cells can be isolated from skin samples for example using single density centrifugation. The percentage of CD8+...
US20180055765 POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE  
A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores...
US20180055752 TOPICAL COMPOSITIONS TO REDUCE HAIR GROWTH  
This document relates to materials and methods for topical administration of sulfonylureas to inhibit, reduce, or prevent hair growth the topical composition being formulated for application to...
US20180055709 Human Machine Interfaces for Lower Extremity Orthotics  
A system and method by which movements desired by a user of a lower extremity orthotic is determined and a control system automatically regulates the sequential operation of powered lower...
US20180055405 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS  
An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and...
US20180055032 ODORS FOR PSYLLID TRAPPING, REPELLING AND CONTROL  
The disclosure provides methods and compositions for modifying psyllid behavior. In addition, the disclosure provides methods and volatile odorants useful for repelling or attracting psyllids.
US20180055022 STERILE MALE INSECTS THAT SIGNIFICANTLY REDUCE LIFESPAN AND EGG-PRODUCTION OF MATED WILD-TYPE FEMALE INSECTS  
Provided herein are methods of generating sterile male insects. The methods include generating a insect stock comprising females with two X chromosomes each having the same centromere with male...
PP28994 Male pistachio tree named ‘Famoso’  
A new male pistachio tree (Pistacia vera L.) designated as ‘Famoso’, particularly characterized by mid- to late-season flowering time, is provided. The male pistachio tree ‘Famoso’ is further...
9906262 All-analog and hybrid radio interference cancellation using cables, attenuators and power splitters  
A radio interference cancellation device that cancels self-interference from a transmitter to a receiver that includes a 2N-way RF power splitter having an input and 2N outputs, a power combiner...
9905239 Methods of decoding speech from the brain and systems for practicing the same  
Provided are methods of decoding speech from the brain of a subject. The methods include detecting speech production signals from electrodes operably coupled to the speech motor cortex of a...
9903855 Assays for screening for or identifying an agent or molecule that can block or inhibit AVB3 integrin from forming a complex with KRAS  
In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing or preventing Growth Factor Inhibitor resistance in a cell, or, a method for increasing...
9903854 Self-powered blood coagulation chip for INR value and hematocrit determination  
A point-of-test diagnostic chip that is capable of simultaneous evaluation of blood coagulation time (INR Value) and hematocrit level. A finger prick volume of blood is placed at the inlet of the...
9903804 Real-time label-free high-throughput cell screening in flow  
A label-free imaging-based flow cytometer that measures size and cell protein concentration simultaneously is disclosed. Cell protein concentration adds a parameter to cell classification that...
9903035 Devices, systems and methods for coating surfaces  
The present disclosure provides devices, systems and methods with applicability in the coating of surfaces, in particular three-dimensional surfaces, via anodization reactions. For example, the...
9902964 Growth arrested cells useful for producing compounds  
The present invention provides for a genetically modified host cell in a growth-arrested state producing an antibiotic.
9902781 Antibodies for botulinum neurotoxins  
The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those...
9902780 Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins  
This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The...
9902058 Multimodal dynamic robotic systems  
Robotic systems include a frame or body with two or more wheels rotatably mounted on the frame or body and a motor for driving each wheel. A system controller generates a signal for actuating each...
9901923 Mobile molecular diagnostics system with wireless communication  
A mobile, self contained molecular diagnostics system is provided with a microfluidic chip, detection apparatus and an integrated or wireless control interface and imager. The system provides...
9901815 Devices, systems, and methods for monitoring, classifying, and encouraging activity  
Devices, methods, and systems for monitoring, classifying and encouraging activity through the use of an accelerometer or other sensor in a toy or other accessory (such as a backpack or watch)...
9901687 Implantable drug-delivery devices, and apparatus and methods for refilling the devices  
In various embodiments, a needle is employed in refilling drug-delivery devices.