Patents and Patent Applications from University of California System


Match Document Document Title
US20180226684 ELECTROLYTE MODULATOR, FABRICATION METHODS AND APPLICATIONS OF SAME  
An electrolyte modulator usable for a metal battery includes a liquid electrolyte; and a material of metal-organic frameworks (MOFs) incorporated in the liquid electrolyte to form a MOF slurry...
US20180226682 COMPOSITE ELECTROLYTE MEMBRANE, FABRICATION METHODS AND APPLICATIONS OF SAME  
A composite electrolyte membrane usable for ionic conductor for an electrochemical device contains a support matrix adapted to function as at least one of a mechanical support, a fire retardant,...
US20180226680 IONIC GEL ELECTROLYTE, ENERGY STORAGE DEVICES, AND METHODS OF MANUFACTURE THEREOF  
An electrochemical cell includes solid-state, printable anode layer, cathode layer and non-aqueous gel electrolyte layer coupled to the anode layer and cathode layer. The electrolyte layer...
US20180224120 BURNER PLATES AND BURNER APPARATUS  
This disclosure provides systems, methods, and apparatus related to burners. In one aspect, an apparatus includes a burner body, an inlet to the burner body, a divider disposed in the burner body,...
US20180223397 TUNGSTEN TETRABORIDE COMPOSITE MATRIX AND USES THEREOF  
Disclosed herein, in certain embodiments, are composite materials, methods, tools and abrasive materials comprising a tungsten-based metal composition, a tungsten carbide, and an alloy. In some...
US20180223376 COMPOSITIONS AND METHODS FOR IDENTIFYING ANTI-CANCER, ANTI-METASTATIC AND ANTI-STRESS AGENTS  
In alternative embodiments, provided are products of manufacture, such as assays, chimeric nucleic acids and nucleic acid constructs, recombinant cells, and methods, comprising use of...
US20180223339 METHODS AND SYSTEMS FOR PHYLOGENETIC ANALYSIS  
The present invention discloses methods and systems for designing and using organism-specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting,...
US20180222915 MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE  
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or...
US20180221651 METHODS OF FABRICATING AN ELECTRODE ARRAY FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE SPINAL CORD  
In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where...
US20180221637 COMPOSITIONS COMPRISING NANOSTRUCTURES FOR CELL, TISSUE AND ARTIFICIAL ORGAN GROWTH, AND METHODS FOR MAKING AND USING SAME  
The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or...
US20180221514 NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES  
The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid...
US20180221512 NIR-CONJUGATED TUMOR-SPECIFIC ANTIBODIES AND USES THEREOF  
Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid...
US20180221435 ITCH TREATMENT USING A COMBINATION OF NEUROKININ-1, GASTRIN RELEASING PEPTIDE, AND GLUTAMATE RECEPTOR ANTAGONISTS  
Methods, and compositions are provided for inhibition of histamine and non-histamine dependent itch signal transmission or scratch behavior. In one aspect, the present invention further comprises...
US20180221331 PREVENTION OF ROSACEA INFLAMMATION  
The disclosure demonstrates the role of mast cell stabilizers in treating rosacea. The disclosure also shows the role of mast cells, cathelicidin, serine protease and/or vitamin D3 in rosacea...
US20180221330 MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT  
The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
US20180220967 WEARABLE ELECTROCHEMICAL SENSORS  
Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor...
US20180220920 NON-CONTACT TOMOGRAPHIC IMAGING AND THIN FILM SENSORS FOR SENSING PERMITTIVITY CHANGES  
Systems and methods for monitoring a change to a region of interest over time are disclosed. Exemplary embodiments may: (a) apply one or more layers of a stress-sensitive material to an object of...
10044031 Graphene oxide as a sulfur immobilizer in high performance lithium/sulfur cells  
A battery is described. The battery is composed of a graphene oxide-sulfur (GO-S) nanocomposite cathode, a separator, an anode, and an electrolyte.
10041936 Neuronal cells cultured on microparticles and methods of using same  
The present invention provides methods for culturing neuronal cells for transplantation into a subject. The methods include culturing neuronal cells with microparticles to provide a microparticle...
10041883 System and method for time-resolved fluorescence imaging and pulse shaping  
A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore...
10041063 Polypeptide display libraries and methods of making and using thereof  
Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of...
10041041 Compositions and methods for treating retinal diseases  
Disclosed herein are compositions and methods for treating, ameliorating or preventing a retinal disease or condition; improving a photopic (day light) vision; for improving correcting visual...
10040844 Proteolytic release of cell surface antigens for phage biopanning  
The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes...
10040780 Mcl-1 antagonists  
Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.
10039816 Siderophore-based immunization against gram-negative bacteria  
The present invention provides novel enterobactin-carrier protein conjugates and salmochelin-carrier protein conjugates, such as compounds of Formula (I), and salts thereof. The present invention...
10039807 bFGF-polymer conjugates, methods for making the same and applications thereof  
A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and...
10039725 Method for treating non-melanoma skin cancer by inducing UDP-glucuronosyltransferase activity using pterostilbene  
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the...
10039685 Passive power-conservative artificial knee  
A passive artificial knee comprises first and second links rotatably coupled at a knee joint, a passive compressive force generator rotatably coupled to the second link, and a release mechanism...
US20180220491 Photonic Near Infrared Heater  
A multilayer photonic stack comprising a lower plurality of alternating layers comprising at least A and B and an upper plurality of alternating layers comprising at least C and D, layer A...
US20180219269 TWO-PORT, THREE-PORT AND FOUR-PORT NON-RECIPROCAL DEVICES WITH SEQUENTIALLY SWITCHED DELAY LINES (SSDL)  
Sequentially-Switched Delay Line (SSDL) can realize passive, nonmagnetic and non-reciprocal components for electromagnetic waves over ultra-wideband through the breaking of the time-reversal...
US20180217143 BIOMARKERS AND METHODS FOR ASSESSING PSORIATIC ARTHRITIS DISEASE ACTIVITY  
Provided herein are biomarkers and methods for generating scores useful for assessing psoriatic arthritis (PsA) disease activity in subjects previously diagnosed with PsA. The invention also...
US20180217094 Isoelectric Focusing Arrays and Methods of Use Thereof  
Isoelectric focusing devices configured for multiplex separation of sample components of interest in a polymeric separation medium are provided. Also provided are methods of using the devices as...
US20180216160 Sequencing of Nucleic Acids via Barcoding in Discrete Entities  
Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods...
US20180216156 COMPOSITIONS AND METHODS FOR MODULATING ABHD2 ACTIVITY  
The present disclosure provides compositions and methods of modulating abhydrolase domain-containing protein-2 (ABHD2). The present disclosure provides methods of identifying agents that modulate...
US20180216113 METHODS FOR REDUCING PROTEOTOXICITY  
The present disclosure provides methods of reducing protein misfolding and/or aggregation in a cell. The present disclosure provides methods of treating diseases and disorders associated with...
US20180216097 SYSTEM FOR CONTINUOUS MUTAGENESIS IN VIVO TO FACILITATE DIRECTED EVOLUTION  
A system for continuous mutagenesis to facilitate directed evolution, the system including DNA polymerases carrying the novel K54E point mutation, and other point mutations including I709N, A759R,...
US20180216094 REVERSAL AGENTS FOR FXIa INHIBITORS  
The disclosure provides compositions and methods for counteracting the effects of direct activated Factor XI (FXIa) inhibitors in a subject by administering a variant of FXIa.
US20180216079 GENERATION OF HUMAN iPS CELLS BY A SYNTHETIC SELF-REPLICATIVE RNA  
The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.
US20180216076 Methods and Compositions for Producing Pancreatic Beta Cells  
Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of...
US20180216003 CO-DOPED CORE/SHELL NANOCRYSTALS FOR VISIBLE LIGHT EMISSION  
In various embodiments the present disclosure provides a core/shell nanocrystal comprising a core and a shell formed on the core, wherein the core/shell nanocrystal is co-doped with at least one...
US20180215783 BIOORTHOGONAL REACTION OF AN AMINE N-OXIDE AND A BORON AGENT  
Methods for chemoselective modification of a target molecule comprising an amine N-oxide in a biological sample are provided. Aspects of the methods include selectively reacting the amine N-oxide...
US20180215773 HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS  
Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe...
US20180215666 STRUCTURAL COMPOSITE MATERIALS  
The disclosure features methods of forming composite materials, and the composite materials formed by such methods. The methods include forming a mixture that includes a binder material and a...
US20180214571 LIPOSOME LOADED WITH MAGNETIC MICROPARTICLES FOR TARGETED DELIVERY OF STEM CELLS  
Compositions and methods are provided for delivery of stem cells to a targeted tissue. A population of stem cells, including for example a regenerative stem cell population, is bound to magnetic...
US20180214339 Methods, Devices and Systems for Orthoptics  
Provided herein is an orthoptic method of improving depth-perception in an individual. Devices, systems and kits for performing the present method are also provided.
US20180214194 SYSTEMS, METHODS, AND MEDIA FOR WIRELESS RADIO FREQUENCY LESIONING  
Systems, methods, and media for wireless radio frequency lesioning are provided. In some embodiments, a system for wireless radio frequency comprises: a wireless radiofrequency device, comprising:...
US20180214046 FOCUSED RECORDING AND STIMULATION ELECTRODE ARRAY  
Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode...
US20180214023 OPTICAL COHERENCE TOMOGRAPHY DEVICE FOR CHARACTERIZATION OF ATHEROSCLEROSIS WITH A 1.7 MICRON SWEPT LASER SOURCE  
An OCT system with a swept light source centered around 1.7 μm for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 μm swept...
10036885 Ultra-fast mechanical shutter  
An electro-mechanical shutter is described. The fast operation is based on a coil operated via a current, where the coil can move within a set of magnets to provide opening and closing of a...
10036699 Parallel flow cytometer using radiofrequency multiplexing  
An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission...