Patents and Patent Applications from University of California System


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US20170349651 PREVENTION AND TREATMENT OF SYNUCLEINOPATHIC AND AMYLOIDOGENIC DISEASE  
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such...
US20170349641 Chiral Substituted Amyloid Beta Peptides  
Aspects of the present disclosure include amyloid β (Aβ) peptides. In certain aspects, the Aβ peptides include a chiral substitution at an electrostatic cluster amino acid residue. Also provided...
US20170349561 SYNTHESIS OF NOVEL IONIC LIQUIDS FROM LIGNIN-DERIVED COMPOUNDS  
Methods and compositions are provided for synthesizing ionic liquids from lignin. Methods and compositions are also provided for treating lignin with ionic liquids.
US20170348665 LANTHANIDE-CHELATOR COMBINATORIAL BARCODING  
Disclosed herein are methods for tracking solutions, (e.g., reaction conditions in solutions). In some embodiments, the method comprises: contacting a first lanthanide-chelator complex to a first...
US20170348521 EXTRACRANIAL IMPLANTABLE DEVICES, SYSTEMS AND METHODS FOR THE TREATMENT OF MEDICAL DISORDERS  
The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically,...
US20170348337 MULTIFUNCTIONAL MEMBRANE-ACTIVE AMINOGLYCOSIDE-PEPTIDE CONJUGATES  
Compositions and methods are disclosed that relate to aminoglycoside-linker-peptide (P-L-A) conjugates having unexpectedly advantageous dual-function bactericidal properties. Encompassed compounds...
US20170348147 IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER  
An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule...
US20170347943 METHODS AND APPARATUS FOR THE ASSESSMENT OF GINGIVAL BLOOD FLOW  
Disclosed herein are methods and apparatus for diagnosing a disease in the gingival region of an individual, comprising: quantitatively measuring blood flow or changes in blood flow in the...
US20170347925 MICRONEEDLE ARRAYS FOR BIOSENSING AND DRUG DELIVERY  
Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid...
9839113 Solid media wakefield accelerators  
Systems and methods for that utilize a compressed coherent high intensity X-ray pulse to drive acceleration of particles in a solid medium laser wakefield accelerator (LWFA).
9839111 Staged Z-pinch for the production of high-flux neutrons and net energy  
A fusible target is embedded in a high Z liner, ohmically heated and then shock wave heated by implosion of an enveloping high Z liner. The target is adiabatically heated by compression, fusibly...
9838048 Channelized active noise elimination (CANE) for bit stream RF transmitters  
A band pass filter is implemented utilizing Channelized Active Noise Elimination (CANE) in combining Finite Impulse Response (FIR) filtering into a radio frequency (RF) transmitter, or...
9835840 Methods for optical amplified imaging using a two-dimensional spectral brush  
An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode...
9835624 Compositions and methods for detecting mycobacterium  
The present disclosure provides methods of detecting mycobacterium in an individual, generally involving detecting antibody to a mycobacterial lipid in a biological sample obtained from the...
9834608 Binding-triggered transcriptional switches and methods of use thereof  
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the binding-triggered transcriptional switch...
9834597 Modified FC polypeptides, FC conjugates, and methods of use thereof  
The present disclosure provides modified Fc domains having one or more attachment moieties for attaching a heterologous functional moiety; and methods of generating the modified Fc domains. The...
9833598 Venous modulation of collateral perfusion of cerebral ischemia  
A patient in whom blood diversion due to cerebral venous steal is present, and abolishment of the cerebral venous steal is indicated, is treated by increasing the cerebral venous pressure in the...
9833309 Thin film vascular stent and biocompatible surface treatment  
A vascular implant, comprising a sheet comprising thin film nickel titanium (NiTi), wherein the sheet has at least one super-hydrophilic surface having a water contact angle of less than...
9833196 Apparatus, system, and method for detecting activities and anomalies in time series data  
Activities and abnormalities in activities are detected by: (1) receiving data corresponding to measurements of an activity occurring during a time interval; (2) determining a plurality of...
9833077 Heated and cooled chair apparatus  
Articles of furniture with a system of heating and cooling that can be integrated into a building environmental control network are provided. The heating/cooling system of the article has surfaces...
US20170346541 Interleaved Training and Limited Feedback for Multiple-Antenna Systems  
A method includes the step of interleaving training and feedback stages in a transmitter and a multiplicity of antennas, wherein the transmitter trains the corresponding ones of the multiplicity...
US20170346376 ENERGY HARVESTER WITH SELF-ASSEMBLED LIQUID BEARING  
A vibration energy harvester that converts kinetic energy to electrical energy. The vibration energy harvester includes an electrically conductive coil array, a magnetic array and a self-assembled...
US20170346104 Redox-Flow Batteries Employing Oligomeric Organic Active Materials and Size-Selective Microporous Polymer Membranes  
Intermittent energy sources, including solar and wind, require scalable, low-cost, multi-hour energy storage solutions to be effectively incorporated into the grid. Redox-flow batteries offer a...
US20170344674 SYSTEM AND METHOD FOR MOLECULAR DESIGN AND SIMULATION  
A system and method for molecular design and simulation is disclosed. In one aspect, a system for simulating a molecular structure includes a processor configured to simulate the molecular...
US20170343531 ON-CHIP PLATFORM FOR SINGLE-MOLECULE ELECTRICAL CONDUCTANCE MEASUREMENTS  
A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical...
US20170342577 NANOELECTRODES FOR WATER SPLITTING  
In various embodiments, the invention teaches a method for water splitting with much higher efficiency than previous methods. By decreasing the distance between two electrodes to nanometer scale,...
US20170342505 Diagnosing and Monitoring CNS Malignancies Using MicroRNA  
The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
US20170342504 EARLY OVARIAN CANCER DETECTION DIAGNOSTIC TEST BASED ON MRNA ISOFORMS  
A method to detect ovarian cancer is provided that employs probes and/or primers to detect certain RNA isoform transcripts, as well as kits therefor.
US20170342496 METHODS FOR EVALUATING, MONITORING, AND MODULATING AGING PROCESS  
Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives,...
US20170342434 Chloroplast Expressing Colostrum or Milk Polypeptides  
Provided are chloroplasts engineered to recombinantly express mammalian colostrum and milk polypeptides photosynthetic organisms containing such chloroplasts, and compositions comprising such...
US20170342423 GENERAL SECRETORY PATHWAY (GSP) MUTANT LISTERIA SPP., AND METHODS FOR MAKING AND USING THE SAME  
General secretory pathway (GSP) mutant Listeria bacteria are provided. Aspects of the bacteria include the presence of a GSP mutation, e.g., a SecY and/or SecA mutation. Also provided are methods...
US20170342278 INFRARED FLUORESCENT COATINGS  
The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment...
US20170342063 BLOCKERS OF THE GROWTH HORMONE RECEPTOR IN DISEASE PREVENTION AND TREATMENT  
Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal...
US20170342020 MODULATORS OF THE EIF2ALPHA PATHWAY  
Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein...
US20170341946 NANOPARTICLE CAPSULES FOR PHOTONIC CRYSTAL COLOR DISPLAY IN MAGNETIC FIELD  
Described are composite photonic materials that incorporate magnetic nanoparticles inside hollow or solvent-filled nano-scale or micro-scale shells and methods of making and using such composite...
US20170341069 NANO-TO-NANO FE/PPM Pd CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER  
In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle...
US20170341063 ZEOLITIC MATERIALS HAVING ENCAPSULATED BIMETALLIC CLUSTERS  
Zeolites having highly dispersed bimetallic clusters, uniformly distributed in size and composition, encapsulated therein are disclosed. Metal encapsulation and alloying is conferred by...
US20170340900 Three-Dimensional Radiotherapy Dose Distribution Prediction  
Generating a three-dimensional radiation dose matrix for a patient for controlling the delivery of radiation dose to patients. The three-dimensional radiation dose matrix for the patient based on...
US20170340706 LOCALLY RELEASED GROWTH FACTORS TO MEDIATE MOTOR RECOVERY AFTER STROKE  
Methods of improving recovery of a mammal after an ischemic event (e.g., stroke) are provided. In various embodiments the methods involve administering a neural growth factor (e.g., BDNF) into the...
US20170340672 CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF  
The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure...
US20170340664 Citrate Containing Beverage  
Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may...
US20170340306 ABDOMINAL STATISTICS PHYSIOLOGICAL MONITORING SYSTEM AND METHODS  
An abdominal statistics system including a low profile rapidly deployable sensor element having an acoustic sensor and vibration actuator that can be conveniently attached to the abdomen of a...
US20170340229 SYSTEM AND METHOD OF IDENTIFYING SOURCES FOR BIOLOGICAL RHYTHMS  
Multiple cardiac signal pairs, each having an analysis signal and a reference signal, are selected from cardiac signals collected from a plurality of sensors associated with locations of the heart...
US20170340202 SCANNING LASER OPHTHALMOSCOPE FOR REAL-TIME EYE TRACKING AND METHOD OF OPERATING SAME  
A scanning laser ophthalmoscope and a method of operating a scanning laser ophthalmoscope are disclosed. The scanning laser ophthalmoscope includes a light source, a reflective optical system, an...
9831502 Free-standing active material/carbon nanomaterial network film as light-weight and high-power electrodes for lithium ion batteries  
An electrode includes a first free-standing carbon network, an active material deposited above the first free-standing carbon network, and a second free-standing carbon network covering the active...
9831008 Inorganic nanostructure-organic polymer heterostructures useful for thermoelectric devices  
The present invention provides for an inorganic nanostructure-organic polymer heterostructure, useful as a thermoelectric composite material, comprising (a) an inorganic nanostructure, and (b) an...
9830920 Method and apparatus for polyphonic audio signal prediction in coding and networking systems  
A method, device, and apparatus provide the ability to predict a portion of a polyphonic audio signal for compression and networking applications. The solution involves a framework of a cascade of...
9829425 Optofluidic devices and methods for sensing single particles  
This disclosure provides systems, methods, and apparatus related to optofluidic devices. In one aspect, an optofluidic device includes a substrate, a first nanostructure, a second nanostructure,...
9828797 Insulated window frame system  
The present invention provides for a window frame comprising a rigid framework cross-section comprising a truss structure.
9828695 Planar nonpolar group-III nitride films grown on miscut substrates  
A nonpolar III-nitride film grown on a miscut angle of a substrate, in order to suppress the surface undulations, is provided. The surface morphology of the film is improved with a miscut angle...