Patents and Patent Applications from University of California System


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US20180125803 METHODS OF INHIBITING PAIN  
Provided are methods and compositions for preventing, reducing, mitigating and treating pain, particularly neuropathic pain by the combined administration of an agent that increases EETs and an...
US20180125425 HYPERTONICITY MEASURING DEVICE AND METHOD  
A hypertonicity measuring device comprises at least one wearable item. The hypertonicity measuring device comprises at least one communication pathway. The at least one communication pathway is...
9967463 Method for camera motion estimation and correction  
A motion estimation and correction system and methods are shown comprising: an image acquisition device configured to acquire an image via scanning an image frame over a period of time, an...
9965586 Noise reduction methods for nucleic acid and macromolecule sequencing  
Methods, systems, and devices are disclosed for processing macromolecule sequencing data with substantial noise reduction. In one aspect, a method for reducing noise in a sequential measurement of...
9964967 System and method for control performance monitoring  
A method for monitoring a control of a parameter of one or more devices or systems in an oil or gas production site includes receiving process data, the process data being a result of the control...
9963699 Methods for modulating C9ORF72 expression  
Disclosed herein are methods for reducing expression of C90RF72 mRNA and protein in an animal with C90RF72 specific inhibitors. Such methods are useful to treat, prevent, or ameliorate...
9963689 Cas9 crystals and methods of use thereof  
The present disclosure provides atomic structures of Cas9 with and without polynucleotides bound thereto. Also provided is a computer-readable medium comprising atomic coordinates for Cas9...
9963356 Alkali metal hafnium oxide scintillators  
The present invention provides for a composition comprising an inorganic scintillator comprising an alkali metal hafnate, optionally cerium-doped, having the formula A2HfO3:Ce; wherein A is an...
9962465 Amelogenin-chitosan hydrogel for dentin hypersensitivity  
A method to regrow a protective layer over exposed/demineralized dentin that includes a step of identifying a subject having exposed/demineralized dentin. The demineralized dentin is contacted...
9962432 Minimizing intestinal dysfunction  
Techniques are disclosed for treating or reducing symptoms associated with abdominal dysfunction or ileus following surgery or other abdominal episode by treating the area with a combination of...
9962395 Compositions and methods for maintaining cognitive function  
Provided are methods for reducing the progression of cognitive decline in a post-menopausal woman using a continuous regimen of estrogen in combination with periodic administration of a progestogen.
9962142 Ultrasound-based volumetric particle tracking method  
The disclosure relates to method of processing three-dimensional images or volumetric datasets to determine a configuration of a medium or a rate of a change of the medium, wherein the method...
US20180123479 Robust single-phase DC/AC inverter for highly varying DC voltages  
A single-phase DC/AC inverter has a single-phase inverter bridge with binary switches connected to an RLC low-pass filter. Digital control logic in a control circuit (or in a microcontroller)...
US20180123251 PERIODICALLY RIPPLED ANTENNA  
A periodically-rippled patch antenna structure with metal coated trenches only along one in-plane direction or in two perpendicular in-plane directions on a dielectric substrate and ground plane...
US20180123138 HIGH PERFORMANCE TRANSITION METAL-DOPED Pt-Ni CATALYSTS  
An electrode material includes a catalyst support and Pt—Ni nanostructures affixed to the catalyst support. The Pt—Ni nanostructures are doped with at least one dopant M.
US20180122916 NANOLAMINATE STRUCTURE, SEMICONDUCTOR DEVICE AND METHOD OF FORMING NANOLAMINATE STRUCTURE  
The present disclosure provides a method of forming a nanolaminate structure. First, a pre-treatment is performed on a semiconductor substrate, in which the semiconductor substrate includes SiGe....
US20180121590 MICROFLUIDICS PLANAR PLACEMENT AND ROUTING ALGORITHM  
A method of developing a physical design layout of microfluidic system chip can include receiving a planarized graph of a netlist including vertices representing microfluidic components. The...
US20180120300 Mitochondrial Apoptotic Sensor  
Mitochondria are central to the intrinsic apoptotic pathway of programmed cell death. Commitment to cell death occurs upon mitochondrial outer membrane permeabilization, and dysregulation of this...
US20180119292 HYBRID PHOTO-ELECTROCHEMICAL AND PHOTO-VOLTAIC CELLS  
This disclosure provides systems, methods, and apparatus related to a hybrid photo-electrochemical and photo-voltaic cell. In one aspect, device includes a substrate comprising a semiconductor, a...
US20180119223 EXONIC SPLICING ENHANCERS AND EXONIC SPLICING SILENCERS  
Compounds and methods for regulation of exonic splicing enhancers and exonic splicing silencers. Compounds include polynucleotides targeted to aberrant exonic splicing enhancers and exonic...
US20180119176 Heterologous Pathway to Produce Terpenes  
Cells comprising a heterologous metabolic pathway are configured to produce a terpene product containing non-multiples of five carbon, particularly wherein the pathway comprises heterologous...
US20180119168 NEGATIVE REGULATOR OF PLANT IMMUNITY AGAINST NEMATODES  
The present invention provides methods of enhancing immunity to root knot nematodes in plants. The methods comprise introducing mutations into a G-LecRK-VI.13 gene or suppressing its expression in...
US20180119122 METHODS AND COMPOSITIONS FOR CELLULAR REPROGRAMMING  
Disclosed herein are methods and pharmaceutical compositions for the treatment of retinitis pigmentosa, macular degeneration and other retinal conditions by interfering with expression of genes,...
US20180118831 CAR T-CELLS FOR THE TREATMENT OF B7-H4 EXPRESSING SOLID TUMORS  
CAR cells and antibodies targeting human B7-H4 expressed on many human cancers including but not limited to breast ovarian, and renal cancers are described as a new method of cancer treatment. It...
US20180118790 Synthetic Beta-Amyloid Peptides Capable of Forming Stable Antigenic Oligomers  
Synthetic Aβ peptides, oligomers, their methods of synthesis, and their applications are provided. The Aβ peptides can form stable, soluble oligomers important for the advancement of knowledge,...
US20180117576 BIOLOGICALLY APPLICABLE WATER-SOLUBLE HETEROGENEOUS CATALYSTS FOR PARA-HYDROGEN INDUCED POLARIZATION  
A heterogeneous catalyst composition for para-hydrogen induced polarization includes ligand-capped nanoparticles dispersed in water. The ligand-capped nanoparticles include metal nanoparticles...
US20180117574 BIARYL LIGANDS FOR TRANSITION METAL-CATALYZED REACTIONS  
In one embodiment, the present application discloses ligands of the formula A, wherein the variables are as described herein, and methods for using the ligands in cross-coupling reactions in...
US20180117282 SPINAL SUBPIAL GENE DELIVERY SYSTEM  
Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near...
US20180116997 METHODS OF INDUCING ANESTHESIA  
The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The...
US20180116541 System and Method for Monitoring and Treating Arrhythmia and Cardiac Function via the Intrinsic Cardiac Nervous System  
The present invention includes systems and methods for measuring, monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system. The systems and methods compare...
US20180116525 FLEXIBLE, NON-INVASIVE REAL-TIME HEMATOMA MONITORING SYSTEM USING NEAR-INFRARED SPECTROSCOPY  
NIRS systems including fully-printed LEDs and PDs operating in the NIR spectrum are provided that provide conformal adherence to a patient's head and efficient measurement of near-infrared...
US20180116141 HAPLOID INDUCTION  
Mutations in CENH3 have been identified that are useful for generating haploid progeny.
RE46817 Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores  
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
9960447 Polymer network single ion conductors  
The disclosure provides for polymer networks that can effectively conduct single ion electrolytes.
9958185 Solar thermal concentrator and method of forming same  
A concentrator tube comprises a reflector portion having two walls; and an aperture closing an opening to the reflector portion. The aperture and the reflector portion extend longitudinally. The...
9957509 Synthetic gene clusters  
Methods for making synthetic gene clusters are described.
9957403 Aqueous dispersion of hydrophobically modified pigment particles  
The present invention relates to a composition comprising a) a stable aqueous dispersion of inorganic pigment particles hydrophobically modified with covalently bonded polysiloxane or silyl...
9956743 Superhydrophobic and superoleophobic nanosurfaces  
Devices, systems and techniques are described for producing and implementing articles and materials having nano-scale and microscale structures that exhibit superhydrophobic, superoleophobic or...
9956551 Nano-to-nano Fe/ppm Pd catalysis of cross-coupling reactions in water  
In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle...
9955886 Focused recording and stimulation electrode array  
Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode...
9955879 System for analysis of complex rhythm disorders  
A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals...
US20180115070 BULK ACOUSTIC WAVE MEDIATED MULTIFERROIC ANTENNAS  
An antenna apparatus utilizing bulk acoustic wave (BAW) resonances to transfer dynamic strain across multiple layers, which include piezoelectric layers coupled to magnetostrictive material...
US20180114637 MAGNETICALLY TUNABLE PHOTONIC CRYSTALS BASED ON ANISOTROPIC NANOSTRUCTURES  
A method is disclosed of forming magnetically tunable photonic crystals comprising: synthesizing one or more precursory nanoparticles with anisotropic shapes; coating the one or more anisotropic...
US20180114096 MACHINE LEARNING TO PROCESS MONTE CARLO RENDERED IMAGES  
A method of rendering an image includes Monte Carlo rendering a scene to produce a noisy image. The noisy image is processed to render an output image. The processing applies a machine learning...
US20180113123 SHRINK ELECTRODE  
A sensor including a flexible substrate, a conductor disposed on the flexible substrate, and a hydrophilic surface coating disposed on the conductor. The flexible substrate and the conductor form...
US20180113112 Methods of Diagnosing Post-Operative Complications Using Serum Nitric Oxide Levels  
Disclosed herein are methods of using serum nitric oxide levels to diagnose subjects as having or likely to develop a post-operative complication.
US20180112200 COMPOSITIONS AND METHODS FOR GENERATING ANTIGENS, ANTIBODIES, AND IMMUNOTHERAPEUTIC COMPOSITIONS AND METHODS  
In some aspects, the invention relates to compositions and methods of generating antigens, wherein the antigen is a biomolecule that is modified by a reactive oxygen species or a reactive nitrogen...
US20180112170 SIEVE SYSTEM AND METHODS FOR CELL MEDIA EXCHANGE  
Methods and systems for cell media exchange wherein media maybe aspirated without also aspirating cells and wherein removal and re-plating of cells is not necessarily required. For example, the...
US20180112034 SUBSTITUTED POLYESTERS BY THIOL-ENE MODIFICATION: RAPID DIVERSIFICATION FOR THERAPEUTIC PROTEIN STABILIZATION  
Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6,...
US20180112003 CAR T-CELL THERAPY DIRECTED TO LHR FOR THE TREATMENT OF SOLID TUMORS  
Provided herein are novel anti-LHR chimeric antigen receptor (CAR), cells or compositions comprising the same, vector or plasmid encoding anti-LHR CAR, and methods for producing the same, or using...