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8153360 |
Flavivirus fusion inhibitors
The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various...
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US20120027844 |
COMPOUNDS, THEIR SYNTHESES, COMPOSITIONS, AND METHODS TO TREAT CANCER
Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes....
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US20120027729 |
METHODS FOR TREATING DIABETES
Transplantation of multipotent stromal cells (MSCs) into diabetic mice lowers blood sugar, increases blood insulin levels, increases the number and size of islets, and improves renal pathology....
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US20110290998 |
TUNED SYNTHETIC DENDRIMER CALIBRANTS FOR MASS SPECTROMETRY
Provided are monodisperse synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf...
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8044292 |
Homogeneous thermoelectric nanocomposite using core-shell nanoparticles
A thermoelectric material comprises core-shell particles having a core formed from a core material and a shell formed from a shell material. In representative examples, the shell material is a...
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US20110237505 |
Compositions and Methods for Treating Obesity and Diabetes
Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin...
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8025861 |
Making electrocatalyst supports for fuel cells
Titanium oxide (usually titanium dioxide) catalyst support particles are doped for electronic conductivity and formed with surface area-enhancing pores for use, for example, in electro-catalyzed...
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8003567 |
Nanocomposite support materials
The present teachings are directed toward hexagonally patterned porous titania synthesized from a titanium isopropoxide precursor using a viscous template of surface-active agents separating...
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US20110190483 |
Stimulus-Responsive Apta Chelamers
Disclosed are apta-chelamers comprising aptamer domains tethered to rationally designed synthetic protein-binding modules, and methods of designing and making the same. Also disclosed are...
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US20110130328 |
FLAVIVIRUS FUSION INHIBITORS
The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various...
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7892515 |
Making mesoporous carbon with tunable pore size
Carbon with mesopores (about two to fifteen nanometers in average pore size) is made using sucrose as a source of carbon, and silica and phosphoric acid as templates for the mesopore structure in...
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7888039 |
Assay for transmissible spongiform encephalopathies
Provided is a novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a body fluid sample from a subject to determine whether the subject has...
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7883995 |
Method of forming stable functionalized nanoparticles
A novel top-down procedure for synthesis of stable passivated nanoparticles uses a one-step mechanochemical process to form and passivate the nanoparticles. High-energy ball milling (HEBM) can...
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7854937 |
Flavivirus fusion inhibitors
The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome...
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US20100278857 |
Dendritic Cell Binding Proteins and Uses Thereof
The present invention provides novel peptides which specifically targets and binds to dendritic cells. Also provided are fusion compositions comprising these peptides and a non-dendritic protein of...
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7824646 |
Carbon and carbon composites with highly ordered mesosize pores
Mesoporous carbon and silica containing composites are prepared based on the co-assembly of a suitable surfactant in a liquid medium. When a low molecular weight carbonizable polymer and a silica...
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7790137 |
Metal telluride nanocrystals and synthesis thereof
A process for synthesizing a metal telluride is provided that includes the dissolution of a metal precursor in a solvent containing a ligand to form a metal-ligand complex soluble in the solvent....
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7771727 |
Conjugates of therapeutic or cytotoxic agents and biologically active peptides
The invention features conjugates of therapeutic or cytotoxic agents and biologically active peptides and methods of use thereof.
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7759329 |
Method of treating human preeclampsia employing resibufagenin
A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of...
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US20100160153 |
MAKING ELECTROCATALYST SUPPORTS FOR FUEL CELLS
Titanium oxide (usually titanium dioxide) catalyst support particles are doped for electronic conductivity and formed with surface area-enhancing pores for use, for example, in electro-catalyzed...
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US20100137877 |
Combined Umbilical Cord Cutter, Clamp, and Disinfectant
Provided is a combined umbilical cord clamp, cutter, disinfectant, and data collecting system which reduces the risk of cord infections due to unsanitary birth conditions. Also provided is an...
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7716969 |
Methods and devices for simultaneously monitoring colloid particles and soluble components during reactions
A method and apparatus for continuously extracting liquid in at least two separate streams from a vessel, continuously diluting and/or conditioning a first stream in one or more stages, producing,...
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US20100021366 |
Making mesoporous carbon with tunable pore size
Carbon with mesopores (about two to fifteen nanometers in average pore size) is made using sucrose as a source of carbon, and silica and phosphoric acid as templates for the mesopore structure in...
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US20090324620 |
CONJUGATES OF THERAPEUTIC OR CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES
The invention features conjugates of therapeutic or cytotoxic agents and biologically active peptides and methods of use thereof.
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US20090306311 |
METHODS AND INSTRUMENTATION FOR DURING-SYNTHESIS MONITORING OF POLYMER FUNCTIONAL EVOLUTION
A method of monitoring the evolution of polymer and/or colloid stimuli responsiveness during synthesis of polymers and/or colloids, including postpolymerization modifications on natural and...
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US20090264362 |
Influenza virus inhibiting peptides
The present invention provides a pharmaceutical composition for the treatment or prevention of an influenza infection. The composition comprises an isolated polypeptide including a sequence of at...
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US20090227676 |
METHODS AND COMPOSITIONS FOR TREATING CANCER
Pharmaceutical compositions and kits useful for the treatment of cancer include certain alkyl esters of cystine and certain alkyl-substituted cystamine derived esters, including, for example,...
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7550423 |
Somatostatin antagonists
The invention features somatostatin antagonists having a D-amino acid at the second residue.
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US20090149378 |
GLP-1 ANALOGUES
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to...
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US20090069245 |
GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and...
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US20090047773 |
METHOD OF FORMING STABLE FUNCTIONALIZED NANOPARTICLES
A novel top-down procedure for synthesis of stable passivated nanoparticles uses a one-step mechanochemical process to form and passivate the nanoparticles. High-energy ball milling (HEBM) can...
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7491793 |
Influenza virus inhibiting peptides
The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus...
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7485460 |
Enhanced growth of adult stem cells with Dkk-1
The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
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US20080299097 |
ISOLATED POPULATION OF RAPIDLY PROLIFERATING MARROW STROMAL CELLS FOR ENHANCED IN VIVO ENGRAFTMENT
Multipotent stromal cells “MSCs” have been described as consisting of at least two populations of cells, rapidly self-renewing stem cells (RS-MSCs), and larger, slowly replicating cells (mM...
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US20080274543 |
Neuronal Cell Propagation Using Rotating Wall Vessel
The present invention provides methods of propagating transformed neurons in a simulated microgravity environment generated by a rotating wall vessel (“3-D culture”) so that the phenotype of the...
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7439071 |
Method of employing elevation of marinobufagenin in determining the presence of preeclampsia and related apparatus
A method of determining the presence of preeclampsia is provided wherein a determination is made as to whether there has been a substantial elevation in marinobufagenin which may be a blood-derived...
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7416733 |
Flavivirus fusion inhibitors
The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome...
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7408024 |
Somatostatin antagonists
The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino acid; A2...
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7381705 |
Inhibitors of hepatitis C virus
The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope...
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7378488 |
Somatostatin antagonists
The present invention is directed to a somatostatin antagonist according to formula (I), wherein A1 is an optionally substituted aromatic ∝-amino acid; A2 is an optionally substituted aromatic ∝...
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7368427 |
GLP-1 analogues
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to...
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US20080095750 |
USE OF ADIPOSE-DERIVED STEM CELLS FOR TREATMENT OF LEUKODYSTROPHIES
The present invention relates to a treatment of a leukodystrophy by administration of an adipose-derived stem cell. Specifically, the present invention relates to the treatment of Krabbe disease...
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7361493 |
Production of urokinase in a three-dimensional cell culture
Embodiments of a method for the production of human urokinase are disclosed. Also disclosed are embodiments of a cell culture well-suited for use with the disclosed method. The method involves...
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US20080090756 |
Somatostatin agonists
Claimed are a series of somatostatin agonists typically characterized by alkylation of the amide nitrogen, and uses thereof. Examples of claimed compounds are those according to formula (I),...
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US20080087314 |
Homogeneous thermoelectric nanocomposite using core-shell nanoparticles
A thermoelectric material comprises core-shell particles having a core formed from a core material and a shell formed from a shell material. In representative examples, the shell material is a...
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US20080085281 |
Inhibitors of Dkk-1
The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells. The present invention also encompasses methods and compositions for regulating the...
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US20080039580 |
Carbon and carbon composites with highly ordered mesosize pores
Mesoporous carbon and silica containing composites are prepared based on the co-assembly of a suitable surfactant in a liquid medium. When a low molecular weight carbonizable polymer and a silica...
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7326685 |
Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q,...
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US20080008623 |
Automatic sampling and dilution apparatus for use in a polymer analysis system
The present invention provides an automatic sampling and dilution apparatus for use in a polymer analysis system. The apparatus comprises (a) a primary mixing chamber; (b) a primary pump capable of...
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7312304 |
Somatostatin agonists
Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, (I) wherein A1, A2, A3, A4, A5 and Y1 are as defined in...
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