Patents and Patent Applications from Tufts University


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US20180050109 SHAPE MEMORY SILK MATERIALS  
The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better...
US20180044643 NON-NEUROINVASIVE VIRUSES AND USES THEREOF  
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
US20180043315 TWO-LAYER NANOFILTRATION MEMBRANES  
A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a...
US20180036453 TISSUE-ENGINEERED SILK ORGANS  
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of...
US20180036434 PHOTOLUMINESCENT NANOPARTICLES AND THEIR USES IN DETECTION OR QUANTIFICATION OF SINGLET OXYGEN  
A composition, as well as methods using the composition, for detection or quantification of a molecule at a singlet state (e.g., singlet oxygen). The composition includes one or more...
9878054 Polypeptide and lipophilic moiety conjugate compositions, formulations, and uses related thereto  
In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of...
9868755 Reagent-controlled stereoselective glycosylation  
Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups.
US20180001278 ZWITTERIONIC COPOLYMERS FOR FOULING RESISTANT FILTRATION MEMBRANES  
A graft copolymer including zwitterionic repeat units and hydrophobic repeat units, in which the zwitterionic repeat units constitute 2-60 wt % of the graft copolymer and each of the hydrophobic...
US20170370709 Imaging System To Characterize Dynamic Changes In Cell And Particle Characteristics  
An imaging system for a biological sample includes a sample container having at least one biological cell that is in contact with an interface surface of a container interface. The imaging system...
US20170366809 MAXIMUM ENTROPY QUANTIZATION OF LINK STATE  
An approach to communication of a quantized value includes communicating one or more parameters characterizing a distribution of the values, and then repeatedly quantizing values according to the...
US20170362310 VHH BASED BINDING ANTIBODIES FOR ANTHRAX AND BOTULINUM TOXINS AND METHODS OF MAKING AND USING THEREFOR  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition...
9839646 Small molecule enhancer for dendritic cell cancer vaccines  
Disclosed is a method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that inhibits a plurality of mammalian DASH serine...
9834616 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
US20170338551 SYSTEM METHOD AND APPARATUS INCLUDING HYBRID SPIRAL ANTENNA  
A spiral antenna device includes a plurality of generally polygonal loops. The polygonal loops have respective side counts that decrease progressively as a function of the loop's radial distance...
US20170333461 PEPTIDOMIMETIC INHIBITORS OF POST-PROLINE CLEAVING ENZYMES  
Disclosed are inhibitors of post-proline cleavage enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In...
US20170333351 METHODS AND COMPOSITIONS FOR PREPARING A SILK MICROSPHERE  
Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all...
US20170320040 METHODS AND KITS FOR REMOVING ORGANIC POLLUTANTS FROM A CONTAMINATED SAMPLE  
Methods and kits for the removal of organic contaminants from contaminated samples are generally provided. In some embodiments, the methods and kits comprise a surfactant and adsorbent particles.
US20170319609 FAP-Activated Therapeutic Agents, and Uses Related Thereto  
Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful...
9809838 Methods for determining the concentration of an analyte in solution  
Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment,...
9808557 Tubular silk compositions and methods of use thereof  
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily...
9802374 Biopolymer sensor and method of manufacturing the same  
A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer...
US20170296696 CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
US20170276669 PRECISE ESTIMATION OF GLOMERULAR FILTRATION RATE FROM MULTIPLE BIOMARKERS  
The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate...
US20170266236 Devices For Wound Healing  
The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.
9767774 Synthesizer with cymbal actuator  
An apparatus for making music includes a cymbal, an acoustic transducer, a signal-processing system that receives a first signal from the acoustic transducer and that generates a second signal...
9765022 Disulfide compounds for delivery of pharmaceutical agents  
A compound of formula the following formula: (I). In this formula, moieties A, B, X, R1, R2, and R3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a...
US20170258889 COMPOSITIONS AND METHODS FOR STABILIZATION OF ACTIVE AGENTS  
Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of...
US20170258781 ATRIAL SPECIFIC ANTIARRHYTHMICS FOR USE IN TREATING OR PREVENTING ATRIAL FIBRILLATION  
The invention relates to methods and compositions for treating or preventing atrial fibrillation.
9761789 Silk-based piezoelectric materials  
The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.
9757400 Peptidomimetic inhibitors of post-proline cleaving enzymes  
Disclosed are inhibitors of post-proline cleavage enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In...
US20170252424 Methods and compositions for vaccinating a subject for a sexually transmitted pathogen  
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly...
9750760 Uridine diphosphate derivatives, prodrugs, compositions and methods for treating neurodegenerative disorders  
This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of...
US20170246255 Stable Analogs of Peptide and Polypeptide Therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
9744220 Compositions and methods for treating inflammatory diseases  
The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor...
US20170242550 DRIFTING KEYBOARD  
A keyboard entry system for use in a touch screen display in which a user touches the display to move a keyboard on the display. The user moves the keyboard until a desired key lies under a fixed...
9737697 Endovascular cerebrospinal fluid shunt  
An endovascular implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends, a one-way valve located at the...
9737696 Endovascular cerebrospinal fluid shunt  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
9737556 FAP-activated therapeutic agents, and uses related thereto  
Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful...
9731052 Methods for stepwise deposition of silk fibroin coatings  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
US20170226155 Smart Pro-Drugs of Serine Protease Inhibitors  
The present invention relates to prodrugs of protease inhibitors, such as inhibitors of the proteosome, DPP IV, FAPα and the like. These“pro-inhibitors” are activated, i.e., cleaved, by an...
9725452 Substituted indoles and pyrroles as RIP kinase inhibitors  
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical...
US20170218339 MICROPHYSIOLOGIC METHODS AND COMPOSITIONS  
The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 μm and 100 μm thick, inclusive, contacting the silk...
US20170218228 Three Dimensional Printing of Bio-Ink Compositions  
3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in...
9720095 System and method for wireless collaborative verification of global navigation satellite system measurements  
Systems and methods are disclosed herein for verifying the quality of global navigation satellite system (GNSS) measurements. The system includes a GNSS receiver, a wireless communications device,...
US20170209676 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
US20170209535 Compositions, methods and kits for treating complement related disorders  
Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55...
US20170204169 METHODS, COMPOSITIONS AND KITS FOR TREATING A SUBJECT USING A RECOMBINANT HETEROMULTIMERIC NEUTRALIZING BINDING PROTEIN  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
US20170202915 Lymphangiogenesis inhibitors for cancer and for graft survival  
Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate...
US20170200909 3D GRAPHENE TRANSISTOR  
A field effect transistor having a channel that comprises three-dimensional graphene foam. The subject matter of the invention concerns a three dimensional field-effect transistor having a channel...
US20170196505 PREDICTIVE INSTRUMENT TO IDENTIFY PATIENTS FOR USE OF PHARMACOLOGICAL CARDIAC METABOLIC SUPPORT  
A purpose-made predictive instrument for the administration of cardiac metabolic support for acute coronary syndromes (ACS, which include unstable angina and acute myocardial infarction) that...