Patents and Patent Applications from Tufts University


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US20170276669 PRECISE ESTIMATION OF GLOMERULAR FILTRATION RATE FROM MULTIPLE BIOMARKERS  
The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate...
US20170266236 Devices For Wound Healing  
The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.
9767774 Synthesizer with cymbal actuator  
An apparatus for making music includes a cymbal, an acoustic transducer, a signal-processing system that receives a first signal from the acoustic transducer and that generates a second signal...
9765022 Disulfide compounds for delivery of pharmaceutical agents  
A compound of formula the following formula: (I). In this formula, moieties A, B, X, R1, R2, and R3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a...
US20170258889 COMPOSITIONS AND METHODS FOR STABILIZATION OF ACTIVE AGENTS  
Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of...
US20170258781 ATRIAL SPECIFIC ANTIARRHYTHMICS FOR USE IN TREATING OR PREVENTING ATRIAL FIBRILLATION  
The invention relates to methods and compositions for treating or preventing atrial fibrillation.
9761789 Silk-based piezoelectric materials  
The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.
9757400 Peptidomimetic inhibitors of post-proline cleaving enzymes  
Disclosed are inhibitors of post-proline cleavage enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In...
US20170252424 Methods and compositions for vaccinating a subject for a sexually transmitted pathogen  
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly...
9750760 Uridine diphosphate derivatives, prodrugs, compositions and methods for treating neurodegenerative disorders  
This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of...
US20170246255 Stable Analogs of Peptide and Polypeptide Therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
9744220 Compositions and methods for treating inflammatory diseases  
The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor...
US20170242550 DRIFTING KEYBOARD  
A keyboard entry system for use in a touch screen display in which a user touches the display to move a keyboard on the display. The user moves the keyboard until a desired key lies under a fixed...
9737697 Endovascular cerebrospinal fluid shunt  
An endovascular implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends, a one-way valve located at the...
9737696 Endovascular cerebrospinal fluid shunt  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
9737556 FAP-activated therapeutic agents, and uses related thereto  
Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful...
9731052 Methods for stepwise deposition of silk fibroin coatings  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
US20170226155 Smart Pro-Drugs of Serine Protease Inhibitors  
The present invention relates to prodrugs of protease inhibitors, such as inhibitors of the proteosome, DPP IV, FAPα and the like. These“pro-inhibitors” are activated, i.e., cleaved, by an...
9725452 Substituted indoles and pyrroles as RIP kinase inhibitors  
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical...
US20170218339 MICROPHYSIOLOGIC METHODS AND COMPOSITIONS  
The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 μm and 100 μm thick, inclusive, contacting the silk...
US20170218228 Three Dimensional Printing of Bio-Ink Compositions  
3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in...
9720095 System and method for wireless collaborative verification of global navigation satellite system measurements  
Systems and methods are disclosed herein for verifying the quality of global navigation satellite system (GNSS) measurements. The system includes a GNSS receiver, a wireless communications device,...
US20170209676 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
US20170209535 Compositions, methods and kits for treating complement related disorders  
Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55...
US20170204169 METHODS, COMPOSITIONS AND KITS FOR TREATING A SUBJECT USING A RECOMBINANT HETEROMULTIMERIC NEUTRALIZING BINDING PROTEIN  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
US20170202915 Lymphangiogenesis inhibitors for cancer and for graft survival  
Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate...
US20170200909 3D GRAPHENE TRANSISTOR  
A field effect transistor having a channel that comprises three-dimensional graphene foam. The subject matter of the invention concerns a three dimensional field-effect transistor having a channel...
US20170196505 PREDICTIVE INSTRUMENT TO IDENTIFY PATIENTS FOR USE OF PHARMACOLOGICAL CARDIAC METABOLIC SUPPORT  
A purpose-made predictive instrument for the administration of cardiac metabolic support for acute coronary syndromes (ACS, which include unstable angina and acute myocardial infarction) that...
9701646 Small molecule inhibitors of PI3-kinase signaling  
Provided are certain 1,2,3-triazole and 1,2,3-triazole dimer analogs of DM-PIT-1 which are second-generation selective non-phosphoinositide small molecule inhibitors of...
9694082 pH induced silk gels and uses thereof  
This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called...
US20170184578 METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
US20170184484 TARGET ANALYTE SENSORS UTILIZING MICROSPHERES  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
9691873 Transient devices designed to undergo programmable transformations  
The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus....
US20170179121 INTEGRATED CIRCUIT WITH MULTI-THRESHOLD BULK FINFETS  
A method for manufacturing a FinFET having a fm that has a fm body includes selecting a desired electrical performance parameter, selecting a base dimension of the fin, identifying a combination...
US20170173161 COMPOSITIONS AND METHODS FOR OCULAR DELIVERY OF A THERAPEUTIC AGENT  
Embodiments of various aspects described herein are directed to silk-based compositions for ocular delivery of at least one active agent, e.g., at least one therapeutic agent and methods of using...
US20170172417 System and Method for Measuring Phase Delay and Amplitude of a Near Infra-Red Signal in Animal Tissue  
A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate...
US20170159104 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION  
Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment,...
US20170156356 BIOPOLYMER-BASED PRESERVATION OF PERISHABLE PRODUCTS  
Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
9664667 Digital quantification of single molecules  
The present disclosure, among other things, methods and systems for digital quantification of single molecule analytes.
9662314 Compounds and methods for the treatment of muscular disease, and related screening methods  
Disclosed are methods of treating a muscle disease and improving normal muscle function by administering a therapeutically effective amount of an isoprenoid antibiotic. Also disclosed are methods...
9655993 Tissue-engineered silk organs  
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of...
US20170128476 FAP-Activated Therapeutic Agents, and Uses Related Thereto  
Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful...
9642994 Endovascular cerebrospinal fluid shunt  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
US20170119901 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO  
Disclosed are prodrugs of therapeutic or imaging agents, which prodrugs are selectively cleaved by fibroblast activating protein (FAP) to release the agents. Upon cleavage by FAP of the FAP...
US20170116971 SYNTHESIZER WITH CYMBAL ACTUATOR  
An apparatus for making music includes a cymbal, an acoustic transducer, a signal-processing system that receives a first signal from the acoustic transducer and that generates a second signal...
9629921 Smart pro-drugs of serine protease inhibitors  
The present invention relates to prodrugs of protease inhibitors, such as inhibitors of the proteosome, DPP IV, FAPα and the like. These“pro-inhibitors” are activated, i.e., cleaved, by an...
US20170107264 FREEZE-DRIED POWDER OF HIGH MOLECULAR WEIGHT SILK FIBROIN, PREPARATION METHOD THEREFOR AND USE THEREOF  
The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution,...
9623147 Concentrated aqueous silk fibroin solution and use thereof  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
9610333 Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines  
Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the...
US20170087279 Radioactive Monolayer Surface Coating  
Disclosed are compositions including a film enriched with a radioisotope relative to its natural abundance, wherein the film has a thickness of one to ten atomic or molecular layers, decay of the...