Patents and Patent Applications from Tufts University


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US20190343137 Biopolymer-Based Preservation of Perishable Products  
Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
10464361 Silk water lithography  
The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and...
10447358 System, method and apparatus for multi-input multi-output communications over per-transmitter power-constrained channels  
A multipath communication system forms a complex weighted compound signal for transmission through a channel environment wherein the compound signal includes a complex variable weighted compound...
US20190309009 URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS  
This disclosure relates to uridine di phosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or...
US20190300860 Innervated Artificial Intestine Compositions  
The present invention provides, among other things, compositions including a plurality of enterocytes, a plurality of fibroblasts, a plurality of Goblet cells, a plurality of Paneth cells, a...
US20190298234 System and Method of Using a Tooth Antenna  
This disclosure provides a dielectric sensor configured to detect a physiological variable within a subject. The dielectric sensor having at least one split-ring resonator configured to be...
US20190293655 METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION  
Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection...
US20190292688 Biomimetic Mechanical Tension Driven Fabrication of Nanofibrillar Architecture  
This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a...
US20190282731 Enzymatically Crosslinked Compositions  
In some embodiments, the present disclosure provides compositions including silk fibroin and a phenol-containing polymer, wherein at least one tyrosine group of the silk fibroin is covalently...
US20190279402 Methods and Systems for Human Imperceptible Computerized Color Transfer  
The present disclosure includes systems and methods for color transfer. The method includes receiving a target image, and determining dominant source colors. The method further includes...
US20190277940 MOBILE NETWORK LOCALIZATION  
A method localizes a first agent in a network including a number of agents, the number of agents including a number of mobile agents and one or more beacons located at known locations. The method...
US20190270822 ANTIBODY-CONJUGATED NANOPARTICLES AND MEDICAL USES THEREOF  
An antibody-conjugated nanoparticle, 50 to 1000 nm in size, containing an anti-Mullerian hormone receptor II (AMHRII) antibody that is conjugated to a nanocomplex formed of a lipid-based delivery...
US20190263999 MACROPOROUS CHITOSAN-POLYACRYLAMIDE HYDROGEL MICROSPHERES AND PREPARATION THEREOF  
Disclosed is a macroporous polymeric hydrogel microsphere that contains polyacrylamide and chitosan. The hydrogel microsphere, having a diameter of 50-250 μm and an average pore size of 1-60 nm,...
US20190262781 FABRICATION OF FILTRATION MEMBRANES  
Disclosed is a method of preparing a filtration membrane. The method includes providing a copolymer solution by dissolving a statistical copolymer in a mixture of a co-solvent and a first organic...
10396173 Transient devices designed to undergo programmable transformations  
The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus....
US20190255181 Silk Powder Compaction for Production of Constructs with High Mechanical Strength and Stiffness  
The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
US20190247803 Biomimetic Multilayer Compositions  
The present invention provides, inter alia, compositions including at least one pliable layer comprising a plurality of silk fibroin nanofibrils, and at least one rigid layer comprising a...
10381719 System method and apparatus including hybrid spiral antenna  
A spiral antenna device includes a plurality of generally polygonal loops. The polygonal loops have respective side counts that decrease progressively as a function of the loop's radial distance...
US20190240288 NANOCOMPLEXES FOR DELIVERY OF SAPORIN  
A nanocomplex, of particle size 50 nm to 1000 nm, containing saporin and a lipid-like compound, in which saporin binds to the lipid-like compound via non-covalent interaction or covalent bonding....
10364441 Methods tip assemblies and kits for introducing material into cells  
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce...
US20190225675 METHODS, COMPOSITIONS AND KITS FOR TREATING A SUBJECT USING A RECOMBINANT NEUTRALIZING BINDING PROTEIN  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
10351617 Compositions, kits and methods for treatment of complement-related disorders  
Methods, compositions and kits for regulating complement activity or treating a complement activity disorder in a subject using soluble, membrane-independent CD59 protein, methods of assaying...
US20190209525 DASH INHIBITORS, AND USES RELATED THERETO  
Disclosed are potent immuno-DASH inhibitors, and their use in the treatment of cell proliferative diseases.
US20190205488 MIS-SPECIFIED MODEL SUPPLEMENTATION  
Methods and systems for generating output of a simulation model in a simulation system are described. In an example, a processor may retrieve observed output data from a memory. The observed...
10335519 Dynamic silk coatings for implantable devices  
Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
US20190187331 Patterned Silk Inverse Opal Photonic Crystals with Tunable, Geometrically Defined Structural Color  
The present disclosure relates to patterned photonic crystals. Provided photonic crystals are large scale silk inverse opals with tunable, geometrically defined structural color. Provided photonic...
US20190177560 Biopolymer-Based Inks and Use Thereof  
The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
US20190175785 SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY  
The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making...
US20190175548 COMPOSITIONS AND METHOD FOR TREATING AND PREVENTING MALNUTRITION  
Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and...
10314938 Concentrated aqueous silk fibroin solution and use thereof  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
US20190169374 COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS  
The present disclosure relates to remediation of contaminated environmental sites. In particular, the present disclosure relates to passive control compositions and their use in remediation.
10285702 Bioresorbable biopolymer anastomosis devices  
A bioresorbable drug-eluting biopolymer suture-free blood vessel anastomosis devices can be deployed to join two blood vessels and resorbed by the body over a predetermined time period after the...
US20190135882 Methods and Systems for Designing and/or Characterizing Soluble Lipidated Ligand Agents  
The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each...
US20190133752 An Artificial Silk Based Innervated Cornea  
In some embodiments, the present invention provides tissue compositions including a first silk scaffold comprising a plurality of epithelial cells, a second silk scaffold comprising a plurality of...
10280204 Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same  
A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound...
10272138 Methods of generating anti-inflammatory stem cells  
The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor...
10271561 Biopolymer-based preservation of perishable products  
Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
US20190111412 FABRICATION OF MACROPOROUS POLYMERIC HYDROGEL MICROPARTICLES  
A polymeric hydrogel microparticle that contains polyacrylamide and chitosan, the chitosan uniformly incorporated in a polyacrylamide matrix. The microparticle, having a coefficient variation of 0...
US20190110688 System and Method for Measuring Phase Delay and Amplitude of an Optical Signal in Animal Tissue  
A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate...
10261089 Methods and arrays for target analyte detection and determination of target analyte concentration in solution  
Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection...
US20190105488 PROGRAMMABLE HYDROGEL IONIC CIRCUITS FOR BIOLOGICALLY MATCHED ELECTRONIC INTERFACES  
The present disclosure relates to programmable hydrogel ionic circuits having properties that are advantageous for use in biological systems. In particular, provided herein are programmable...
10254900 Drifting keyboard  
A keyboard entry system for use in a touch screen display in which a user touches the display to move a keyboard on the display. The user moves the keyboard until a desired key lies under a fixed...
US20190099459 Methods and compositions for preventing infection by a Vibrio species  
Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the...
10245248 FAP-activated therapeutic agents, and uses related thereto  
Disclosed are prodrugs of therapeutic or imaging agents, which prodrugs are selectively cleaved by fibroblast activating protein (FAP) to release the agents. Upon cleavage by FAP of the FAP...
10241026 Target analyte sensors utilizing microspheres  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
US20190085140 SILK-BASED NANOIMPRINTING  
Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled...
US20190083462 PREVENTION OF NSAID ENTEROPATHY WITH MICROBIOTA-DERIVED TRYPTOPHAN-METABOLITE  
This disclosure relates to methods and compositions for addressing conditions of dysbiosis and/or inflammation, such as enteropathy, associated with administration of non-steroidal...
10233219 Methods and systems for designing and/or characterizing soluble lipidated ligand agents  
The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each...
10226509 Lymphangiogenesis inhibitors for cancer and for graft survival  
Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate...
US20190055279 NOVEL POLYPEPTIDES WITH IMPROVED PROTEOLYTIC STABILITY, AND METHODS OF PREPARING AND USING SAME  
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the...