Patents and Patent Applications from Tufts University


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US20180258389 METHODS OF GENERATING NEURAL STEM CELLS  
In some embodiments, the present invention provides methods including the steps of providing one or more human somatic cells, causing transient increased expression of OCT4, KLF4, SOX2, and cMYC...
US20180256697 NON-TOXIGENIC CLOSTRIDIUM DIFFICILE SPORES FOR USE IN ORAL VACCINATION  
Described are non-toxigenic Clostridium difficile strains and spores. Also described are vaccines comprising the Clostridium difficile spores. Further described are methods of preventing or...
US20180243541 SYSTEM FOR TREATING ACUTE AND CHRONIC HEART FAILURE  
Systems and methods and devices are provided for arresting or reversing the effects of myocardial remodeling and degeneration after cardiac injury, without the potential drawbacks associated with...
US20180243479 INJECTABLE, FLEXIBLE HYDROXYAPATITE-SILK FOAMS FOR OSTEOCHONDRAL AND DENTAL REPAIR  
The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are...
10058514 Silk-based scaffold platform for engineering tissue constructs  
The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described...
US20180228436 THREAD-BASED INTEGRATED FUNCTIONAL DEVICES  
A composite thread includes first and second segments joined to each other. The first segment comprises a functional segment that interacts with an environment of the thread. The second segment...
10044062 Silicone-containing ionic materials  
An ionic material that contains a crosslinked polydimethylsiloxane network and an ionic liquid and, optionally, a lithium salt. Also disclosed are a methods of preparing the above-described ionic...
10040834 Biopolymer optofluidic device and method of manufacturing the same  
A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the...
US20180217048 TARGET ANALYTE SENSORS UTILIZING MICROSPHERES  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
10035920 Biopolymer-based inks and use thereof  
The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
10034945 Silk powder compaction for production of constructs with high mechanical strength and stiffness  
The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
10022407 Use of a lactobacillus rhamnosus strain for reducing weight gain and/or insulin resistance  
Provided are the use of Lactobacillus rhamnosus strain CNCM I-3690 for reducing diet-induced weight gain and/or diet-induced insulin resistance, and treating disorders resulting therefrom, such as...
US20180188260 METHOD OF QUANTIFYING CELL PENETRATION OF A MOLECULE  
As described below, the invention provides methods for localizing and quantifying the extent to which a molecule penetrates a cell.
US20180175158 Transient Devices Designed to Undergo Programmable Transformations  
The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus....
9993527 Silk fibroin materials and use thereof  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...
US20180155666 Low Surface Energy Coatings For Mammalian Cell Culture  
A cultureware system is directed to maintaining viability of mammalian cells, and includes a disposable holding container having a cell receiver with a cell-receiving surface. The cell receiver...
9987346 Methods and compositions for vaccinating a subject for a sexually transmitted pathogen  
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly...
9987243 Use of trans-palmitoleate in identifying and treating metabolic disease  
The present invention provides for a novel lipokine, trans-C16:1n7-palmitoleate, which also serves as a biomarker for metabolic status. More specifically, low concentrations of...
9986924 Implantable biomedical devices on bioresorbable substrates  
Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to...
US20180149653 COMPOSITIONS AND METHODS FOR DIAGNOSING BREAST CANCER  
The invention provides methods and compositions for distinguishing breast cancer.
9975037 Sudoku arrays  
Provided herein is technology relating to generating a Sudoku array and particularly, but not exclusively, to methods and systems for generating a Sudoku array for a puzzle or for encrypting data.
US20180136203 METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
US20180133657 TWO-LAYER PHOTO-RESPONSIVE MEMBRANES  
A two-layer photo-responsive membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer is formed of a graft...
US20180133656 ZWITTERIONIC FIBER MEMBRANES  
A polymer fiber formed of statistical copolymers, each of which contains zwitterionic repeat units and hydrophobic repeat units, the zwitterionic repeat units constituting 20-75 wt % of the...
9969134 Nanopatterned biopolymer optical device and method of manufacturing the same  
A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a...
9968258 Imaging fluorescence or luminescence lifetime  
Devices for use in fluorescence or luminescence lifetime imaging include a chip featuring an imaging region that includes a photodetector for receiving optical signals, and a time-to-digital...
9964476 Shear sensor array  
The present disclosure relates to shear sensor arrays. In particular, the present disclosure relates to a floating element shear stress sensor array on a chip that is calibrated to high shear...
9956297 FAP-activated proteasome inhibitors for treating solid tumors  
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also...
9952148 Non-invasive optical characterization of biomaterial mineralization  
In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing...
US20180105666 FABRICATION OF MACROPOROUS MONODISPERSE HYDROGEL MICROSPHERES  
A macroporous polymeric hydrogel microsphere that contains poly(ethylene glycol), chitosan, and water. The hydrogel microsphere, having a diameter of 50-250 gm and a mesh size of 5-100 nm, is...
US20180092933 SMALL MOLECULE ENHANCER FOR DENDRITIC CELL CANCER VACCINES  
Disclosed is a method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that inhibits a plurality of mammalian DASH serine...
9936574 Waterproof stretchable optoelectronics  
Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful...
9931434 Injectable silk fibroin particles and uses thereof  
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such...
US20180091199 System, Method and Apparatus for Multi-Input Multi-Output Communications over Per-Transmitter Power-Constrained Channels  
A multipath communication system forms a complex weighted compound signal for transmission through a channel environment wherein the compound signal includes a complex variable weighted compound...
US20180088051 System And Method For Assessing Cellular Metabolic Activity  
Methods and corresponding apparatus and systems for assessing cellular metabolic activity are disclosed. In one aspect, a cell can be illuminated with optical radiation in order to cause...
US20180085386 URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE  
This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside...
9925301 Methods of producing and using silk microfibers  
Provided herein relates to methods for preparing micron range silk fibers (or silk microfibers) and compositions comprising a micron range silk fiber (or a silk microfiber). The micron range silk...
9925299 Silk-based fabrication techniques to prepare high strength calcium phosphate ceramic scaffolds  
The disclosure provides ceramic materials comprising calcium phosphate material and silk and processes and methods for preparing and uses thereof.
US20180078587 COMPOSITIONS AND METHODS FOR PREVENTING COLORECTAL CANCER  
Provided herein are compositions and methods for preventing and/or reducing the risk of colorectal cancer. In particular, provided herein are probiotic and small molecule agents and their use in...
US20180071434 SCAFFOLDS AND METHODS OF MAKING AND USING THE SAME  
The present disclosure relates to scaffolds such as protein hydrogel scaffolds. The present disclosure provides methods and technologies that permit formation of cavities within hydrogel...
9914950 Homopolymer mediated nucleic acid amplification  
According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-mediated ligation. The methods, in some embodiments, comprise adding a first...
9913855 Uridine diphosphate derivatives, prodrugs, compositions and uses thereof  
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs...
US20180055917 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES  
The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor...
US20180050109 SHAPE MEMORY SILK MATERIALS  
The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better...
US20180044643 NON-NEUROINVASIVE VIRUSES AND USES THEREOF  
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
US20180043315 TWO-LAYER NANOFILTRATION MEMBRANES  
A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a...
US20180036453 TISSUE-ENGINEERED SILK ORGANS  
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of...
US20180036434 PHOTOLUMINESCENT NANOPARTICLES AND THEIR USES IN DETECTION OR QUANTIFICATION OF SINGLET OXYGEN  
A composition, as well as methods using the composition, for detection or quantification of a molecule at a singlet state (e.g., singlet oxygen). The composition includes one or more...
9878054 Polypeptide and lipophilic moiety conjugate compositions, formulations, and uses related thereto  
In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of...
9868755 Reagent-controlled stereoselective glycosylation  
Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups.