Patents and Patent Applications from Tufts University


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9132197 Silk fibroin materials and use thereof  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...
US20150243041 SYSTEMS AND METHODS FOR IMAGE AND VIDEO SIGNAL MEASUREMENT  
An image/video may be analyzed to determine quality of its attributes, including local, global and pixel colorfulness, sharpness, and contrast to obtain an image quality measure. Invented quality...
US20150238617 SILK RESERVOIRS FOR SUSTAINED DELIVERY OF ANTI-CANCER AGENTS  
The present invention on directed to silk-based drug delivery compositions for sustained delivery of drugs, e.g., for cancer therapy, and methods of their use for treatment.
US20150233905 METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION  
Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection...
US20150231311 METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
9108955 Heterocyclic inhibitors of necroptosis  
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by...
9102916 Tissue-engineered silk organs  
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of...
9102756 Stable analogs of peptide and polypeptide therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20150216990 Polypeptide and Lipophilic Moiety Conjugate Compositions, Formulations, and Uses Related Thereto  
In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of...
9095420 Endovascular stent  
An intravascular stent is provided for treatment of an aneurysm in a vessel wall of a cranial blood vessel. The stent includes at least one a flow-shaping member including a flow-facing surface...
9090833 Converting biomass to gaseous fuel hydrocarbons  
A method for producing a C1-5 hydrocarbon from a solution containing a C2-6 carboxylic acid or a C2-6 carboxylate which is derived from biomass by contacting the solution with a solid catalyst to...
US20150204853 MODULATORS OF ION TRANSPORT PROTEINS OR ION CHANNELS AND METHODS OF IDENTIFYING AND USING SAME  
Described herein are materials and methods for measuring intracellular ion concentrations, materials and methods for identifying modulators of intracellular ion concentrations, modulators if...
US20150203887 HOMOPOLYMER MEDIATED NUCLEIC ACID AMPLIFICATION  
According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-dedicated ligation. The methods, in some embodiments, comprise adding a first...
US20150202351 DYNAMIC SILK COATINGS FOR IMPLANTABLE DEVICES  
Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
US20150202304 ENCAPSULATION OF IMMISCIBLE PHASES IN SILK FIBROIN BIOMATERIALS  
Embodiments of various aspects described herein relates to compositions and methods for encapsulation and/or stabilization of oil, lipid, hydrophobic and/or lipophilic compounds in a silk-based...
US20150202292 ELECTROCHEMICALLY DEGRADABLE POLYMERS  
The present invention discloses polymeric materials that incorporate a modified quinone moiety, either to cross-link the polymer or as a monomeric unit of the polymer These polymeric materials can...
US20150202218 Broad Spectrum Inhibitors of the Post Proline Cleaving Enzymes for Treatment of Hepatitis C Virus Infections  
Disclosed are methods of treating, inhibiting, or preventing a viral infection in a mammal in need thereof by administering a therapeutically or prophylactically effective amount of an inhibitor...
9084840 Concentrated aqueous silk fibroin solution and use thereof  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
US20150197778 TRIGLYCERIDE PRODUCTION IN E. COLI  
A recombinant E. coli cell including nucleic acid sequences that encode phosphatidic acid phosphatase (PGP) and diacylglycerol acyltransferase (DGAT). Upon expression of the PGP and DGAT, the cell...
US20150196741 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...
9080172 Targeting p63 to re-activate dormant reserve stem cells in olfactory epithelium  
Disclosed herein is a method for activating a dormant epithelial stem cell, or population thereof, to a state of multipotency comprising, reducing the level of ΔNp63 in the cell(s). The dormant...
9074302 Methods of making drawn silk fibers  
The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is...
US20150183841 HIGH MOLECULAR WEIGHT SILK FIBROIN AND USES THEREOF  
Provided herein relates to high molecular weight silk-based materials, compositions comprising the same, and processes of preparing the same. The silk-based materials produced from high molecular...
9068987 Inhibitors of extracellular HSP90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
9068282 System and method for making biomaterial structures  
A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is...
US20150174256 SILK POWDER COMPACTION FOR PRODUCTION OF CONSTRUCTS WITH HIGH MECHANICAL STRENGTH AND STIFFNESS  
The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
US20150173621 Imaging Fluorescence or Luminescence Lifetime  
Among other things, devices for use in fluorescence or luminescence lifetime imaging are described. The devices include integrated complementary metal-oxide semiconductor (CMOS) chips that include...
US20150165092 METHODS OF PRODUCING AND USING SILK MICROFIBERS  
Provided herein relates to methods for preparing micron range silk fibers (or silk microfibers) and compositions comprising a micron range silk fiber (or a silk microfiber). The micron range silk...
US20150164117 ENCAPSULATION OF FRAGRANCE AND/OR FLAVORS IN SILK FIBROIN BIOMATERIALS  
Embodiments of various aspects described herein relates to compositions and methods for encapsulation and/or stabilization of odor-releasing substances (e.g., fragrances) and/or flavoring...
US20150157684 Soft Protease Inhibitors and Pro-Soft Forms Thereof  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
US20150151525 PAINT-ON APPROACH FOR FABRICATION OF ELECTRICALLY ACTIVE STRUCTURES  
A method of making an electrically active structure includes applying a backplane onto a substrate, applying a paint layer onto said backplane, applying a stencil layer on said paint layer,...
US20150151221 METHOD AND DEVICE FOR THE CONCENTRATION OF MULTIPLE MICROORGANISMS AND TOXINS FROM LARGE LIQUID TOXINS  
A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl...
US20150150993 SILK MICROSPHERES AND METHODS FOR SURFACE LUBRICATION  
Provided herein relates to compositions and methods for lubrication of a surface. The surface amenable to the compositions and methods described herein can be a non-biological surface, a...
9044424 Methods of regulating glucose metabolism, and reagents related thereto  
The present invention provides methods for modification and regulation of glucose metabolism by administering to an animal a therapeutically effective amount of an inhibitor of dipeptidylpeptidase...
9040585 Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof  
Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH)...
9040073 Silk polymer-based adenosine release: therapeutic potential for epilepsy  
The invention provides formulations comprising adenosine in a silk fibroin-based, sustained-release delivery system. The formulations provide sustained, focal release of adenosine at therapeutic...
US20150123670 IN SITU SENSING OF COMPOUNDS  
The disclosure features systems and methods for detecting organic compounds that include: (a) a transfer line; (b) a probe connected to a first end of the transfer line, the probe including an...
9023352 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
US20150114077 SHEAR SENSOR ARRAY  
The present disclosure relates to shear sensor arrays. In particular, the present disclosure relates to a floating element shear stress sensor array on a chip that is calibrated to high shear...
9017991 Methods tip assemblies and kits for introducing material into cells  
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce...
9016875 All-protein implantable, resorbable reflectors  
The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk...
US20150112612 DIGITAL QUANTIFICATION OF SINGLE MOLECULES  
The present disclosure, among other things, methods and systems for digital quantification of single molecule analytes.
US20150104390 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS  
The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk...
9006972 Microplasma generator and methods therefor  
A low-temperature, atmospheric-pressure microplasma generator comprises at least one strip of metal on a dielectric substrate. A first end of the strip is connected to a ground plane and the...
US20150099870 Glycosylation Reactions Using Phenyl(trifluoroethyl)iodonium Salts  
Provided are methods for the preparation of glycosylation products, including those represented by formula I: Sugar-O—R′ I comprising the step of combining R′—OH, a glycosyl sulfide glycosyl donor...
US20150099787 Non-Flushing Niacin Analogues, and Methods of Use Thereof  
One aspect of the present invention relates to substituted pyridines and pharmaceutially acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the...
US20150094303 Niacin Mimetics, and Methods of Use Thereof  
Disclosed are heterocyclylalkyl-substituted and heteroaralkyl-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian...
US20150093384 Methods and systems for multi-antibody therapies  
The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each...
US20150086605 MULTI-LAYER BIOMATERIAL FOR TISSUE REGENERATION AND WOUND HEALING  
The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some...
8986380 Multilayered silk scaffolds for meniscus tissue engineering  
Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each...