Patents and Patent Applications from Tufts University


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US20160009643 DISULFIDE COMPOUNDS FOR DELIVERY OF PHARMACEUTICAL AGENTS  
A compound of formula the following formula: (I). In this formula, moieties A, B, X, R1, R2, and R3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a...
US20160008309 USE OF TRANS-PALMITOLEATE IN IDENTIFYING AND TREATING METABOLIC DISEASE  
The present invention provides for a novel lipokine, trans-C16:ln 7-palmitoleate, which also serves as a biomarker for metabolic status. More specifically, low concentrations of trans-C16:ln...
US20160000857 Method of Regulating Glucose Metabolism, and Reagents Related Thereto  
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinenmia,...
9227993 Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders  
This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or...
US20150374802 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES  
The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor...
US20150368417 SILK-BASED NANOIMPRINTING  
Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled...
US20150366514 COHERENT HEMODYNAMICS SPECTROSCOPY AND MODEL BASED CHARACTERIZATION OF PHYSIOLOGICAL SYSTEMS  
A method for inferring characteristics of a physiological system includes measuring one or more physiological signals in the physiological system and inferring characteristics of the physiological...
9216813 Inflatable and rigidizable support element  
The present invention provides novel inflatable and rigidizable support elements, and methods of manufacture and use thereof. In particular, the present invention provides inflatable and...
US20150361429 METHODS AND COMPOSITIONS FOR TARGETING IMMUNOGLOBULINS  
The present invention relates to compositions and methods for targeting immunoglobulins and immunoglobulin-producing plasma cells. In particular, the present invention provides nucleic acid based...
9212142 Niacin mimetics, and methods of use thereof  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
US20150353612 NUCLEIC ACIDS ENCODING PEPTIDES FOR TREATING WOUNDS, ANTI-ANGIOGENIC COMPOUNDS AND USES THEREOF  
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides...
9199067 Endovascular cerebrospinal fluid shunt  
An endovascular implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends, a one-way valve is located at...
9193708 Non-flushing niacin analogues, and methods of use thereof  
One aspect of the present invention relates to substituted pyridines and pharmaceutially acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the...
9192646 Soft protease inhibitors and pro-soft forms thereof  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
US20150328266 Use of Bifidobacterium Animalis for Treating or Preventing Body Weight Gain and Insulin Resistance  
Provided is the use of Bifidobacterium animalis subsp. lactis strain CNCM I-2494 for decreasing diet-induced body weight gain and improving diet-induced insulin resistance in a subject.
US20150320782 Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor  
Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, such that composition includes a pharmaceutically suitable carrier or...
US20150307728 BIOPOLYMER-BASED INKS AND USE THEREOF  
The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
US20150299795 CANCER-ASSOCIATED GERM-LINE AND SOMATIC MARKERS AND USES THEREOF  
The invention provides methods and compositions for identifying subjects, including canine subjects, having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects...
US20150297646 Use of a Lactobacillus rhamnosus strain for reducing weight gain and/or insulin resistance  
Provided are the use of Lactobacillus rhamnosus strain CNCM 1-3690 for reducing diet-induced weight gain and/or diet-induced insulin resistance, and treating disorders resulting therefrom, such as...
9163055 Methods for treating glaucoma using uridine diphosphate derivatives  
This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of...
US20150291848 DIAZONIUM SALT MODIFICATION OF SILK POLYMER  
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk...
9157113 Self-encoding sensor with microspheres  
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
US20150284741 Methods, tip assemblies and kits for introducing material into cells  
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce...
US20150283298 SILK-BASED FABRICATION TECHNIQUES TO PREPARE HIGH STRENGTH CALCIUM PHOSPHATE CERAMIC SCAFFOLDS  
The disclosure provides ceramic materials comprising calcium phosphate material and silk and processes and methods for preparing and uses thereof.
US20150273021 COMPOSITIONS AND METHODS FOR SUSTAINED DELIVERY OF GLUCAGON-LIKE PEPTIDE (GLP-1) RECEPTOR AGONIST THERAPEUTICS  
The present invention is directed to silk-based drug delivery compositions or compositions for sustained delivery of therapeutic agent(s), such as glucagon-like peptide (GLP-1) receptor agonists,...
US20150272903 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS  
The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale...
US20150267187 Designer Ubiquitin Ligases for Regulation of Intracellular Pathogenic Proteins  
The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes an antibody fragment that is specific for a toxin active fragment, wherein the toxin active...
US20150265647 URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF  
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs...
9142787 Silk transistor devices  
The invention relates to ecosustainable and biocompatible, low cost, ambient friendly electronic and optoelectronic devices, such as transistors and light-emitting transistors, made with silk...
US20150258199 METHOD FOR SILK FIBROIN GELATION USING SONICATION  
This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after...
9132197 Silk fibroin materials and use thereof  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...
US20150243041 SYSTEMS AND METHODS FOR IMAGE AND VIDEO SIGNAL MEASUREMENT  
An image/video may be analyzed to determine quality of its attributes, including local, global and pixel colorfulness, sharpness, and contrast to obtain an image quality measure. Invented quality...
US20150238617 SILK RESERVOIRS FOR SUSTAINED DELIVERY OF ANTI-CANCER AGENTS  
The present invention on directed to silk-based drug delivery compositions for sustained delivery of drugs, e.g., for cancer therapy, and methods of their use for treatment.
US20150233905 METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION  
Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection...
US20150231311 METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
9108955 Heterocyclic inhibitors of necroptosis  
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by...
9102916 Tissue-engineered silk organs  
This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of...
9102756 Stable analogs of peptide and polypeptide therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20150216990 Polypeptide and Lipophilic Moiety Conjugate Compositions, Formulations, and Uses Related Thereto  
In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of...
9095420 Endovascular stent  
An intravascular stent is provided for treatment of an aneurysm in a vessel wall of a cranial blood vessel. The stent includes at least one a flow-shaping member including a flow-facing surface...
9090833 Converting biomass to gaseous fuel hydrocarbons  
A method for producing a C1-5 hydrocarbon from a solution containing a C2-6 carboxylic acid or a C2-6 carboxylate which is derived from biomass by contacting the solution with a solid catalyst to...
US20150204853 MODULATORS OF ION TRANSPORT PROTEINS OR ION CHANNELS AND METHODS OF IDENTIFYING AND USING SAME  
Described herein are materials and methods for measuring intracellular ion concentrations, materials and methods for identifying modulators of intracellular ion concentrations, modulators if...
US20150203887 HOMOPOLYMER MEDIATED NUCLEIC ACID AMPLIFICATION  
According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-dedicated ligation. The methods, in some embodiments, comprise adding a first...
US20150202351 DYNAMIC SILK COATINGS FOR IMPLANTABLE DEVICES  
Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
US20150202304 ENCAPSULATION OF IMMISCIBLE PHASES IN SILK FIBROIN BIOMATERIALS  
Embodiments of various aspects described herein relates to compositions and methods for encapsulation and/or stabilization of oil, lipid, hydrophobic and/or lipophilic compounds in a silk-based...
US20150202292 ELECTROCHEMICALLY DEGRADABLE POLYMERS  
The present invention discloses polymeric materials that incorporate a modified quinone moiety, either to cross-link the polymer or as a monomeric unit of the polymer These polymeric materials can...
US20150202218 Broad Spectrum Inhibitors of the Post Proline Cleaving Enzymes for Treatment of Hepatitis C Virus Infections  
Disclosed are methods of treating, inhibiting, or preventing a viral infection in a mammal in need thereof by administering a therapeutically or prophylactically effective amount of an inhibitor...
9084840 Concentrated aqueous silk fibroin solution and use thereof  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
US20150197778 TRIGLYCERIDE PRODUCTION IN E. COLI  
A recombinant E. coli cell including nucleic acid sequences that encode phosphatidic acid phosphatase (PGP) and diacylglycerol acyltransferase (DGAT). Upon expression of the PGP and DGAT, the cell...
US20150196741 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to...