Patents and Patent Applications from Tufts University


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7094806 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
7094206 System for measuring respiratory function  
The present invention relates to a system for measuring respiratory function of living organisms. More particularly, signals indicative of the change in lung volume, defined as active and passive...
US20060167114 Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors  
NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in...
US20060166946 Methods of preparing substituted tetracyclines with transition metal-based chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods...
US20060166274 G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
US20060159837 Method for forming inorganic coatings  
The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an...
7078381 Method of regulating glucose metabolism, and reagents related thereto  
The present invention provides methods and compositions for modifying glucose metabolism and treating Type II diabetes in an animal, along with modifying metabolism of a peptide hormone in an...
7067681 Methods of preparing substituted tetracyclines with transition metal-based chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods...
US20060128565 Catalyst having metal in reduced quantity and reduced cluster size  
The invention contemplates a method of making a catalytic material, and uses of the material. The catalytic material is made by depositing catalytic metals, such as gold or platinum, on substrate...
7062385 Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air  
The present invention generally relates to nucleic acid-based sensors and methods for detecting volatile analytes. More particularly, this invention relates to nucleic acid-based optical sensors,...
7060676 T. cruzi-derived neurotrophic agents and methods of use therefor  
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
US20060106293 Optical imaging and oximetry of tissue  
Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of...
7047055 Fetal pulse oximetry  
A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a...
US20060100274 Therapeutic avenanthramide compounds  
Methods and compositions are disclosed for reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present...
7026136 Methods of reducing microbial resistance to drugs  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
US20060073483 Electro-optical nucleic acid-based sensor array and method for detecting analytes  
The present invention is directed to methods of detection, identification and monitoring of vapor phase analytes by using sensor arrays comprising fluorophore labeled nucleic acids, dried onto a...
US20060073151 Inhibitors of extracellular Hsp90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
US20060069030 Apolipoprotein A1 mimetics and uses thereof  
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
7011946 In vivo assay for identification of antimicrobial agents  
The present invention provides novel in vivo assay systems and methods of using these assays systems to identify compounds that affect microbial cell division. The present invention further...
US20060035817 Use of galectin-3 and galectin-7 to promote the re-epithelialization of wounds  
Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3...
6999657 High density optical data storage  
A data storage apparatus includes an array of optical fibers. The array has a first end and a second end. The first end of the array includes multiple optical fiber ends, each optical fiber end...
6994992 Androgen-induced suppressor of cell proliferation and uses thereof  
The invention provides novel AS3 nucleic acid sequences, AS3 polypeptides, anti-AS3 antibodies, and methods for modulating cell proliferation and detecting compounds that modulate cell...
6991939 Optical array device and methods of use thereof for screening, analysis and manipulation of particles  
Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A multi-channel device parcels a light source...
US20060015950 Nuclear transfer embryo formation method  
A nuclear transfer embryo is formed by destabilizing microtubules of an oocyte, whereby essentially all endogenous chromatin collects at a second polar body during meiosis of an oocyte. The oocyte...
US20060013543 Electro-optical stimulation/measurement  
An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the...
6985763 Method for measuring venous oxygen saturation  
A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced...
6982132 Rechargeable thin film battery and method for making the same  
A rechargeable, stackable, thin film, solid-state lithium electrochemical cell, thin film lithium battery and method for making the same is disclosed. The cell and battery provide for a variety...
US20050287169 Methods of use of genes of pyridoxal 5'-phosphate biosynthesis in Bacillus subtilis: avirulent strains for vaccines, and methods for identification of antibacterial agents  
Methods and compositions comprising a pathogenic bacterial strain having a non-reverting mutation in a pdx gene encoding an enzyme involved in pyridoxal-5′-phosphate synthesis are provided, for...
US20050261165 Methods of reducing microbial resistance to drugs  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
US20050260706 Silk biomaterials and methods of use thereof  
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer,...
6967021 Use of Galectin-3 to promote the re-epithelialization of wounds  
Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3...
US20050251901 Chest wall protector  
A chest wall protector comprises a shell made of a relatively hard, rigid material, a cushion attached to the shell such that the cushion is disposed between the shell and a thoracic wall of a...
US20050250855 Compounds for treating human papillomavirus  
Methods and compositions for treating human papillomavirus infections are described.
US20050250744 Pharmaceutically active compounds and methods of use thereof  
The invention includes new substituted tetracycline-type compounds that exhibit significant antibacterial activity, including against both gram-positive and gram-negative bacteria. It has been...
US20050239892 Therapeutic avenathramide compounds  
Methods and compositions are disclosed for reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present...
US20050227219 Method for suppression or reversing of cellular aging  
A method is provided for growing young cells that reduces and/or reverses age-related processes that would otherwise occur in those cells, and also compositions for growing cells in such a method.
US20050226774 Total organic carbon (toc) analyzer  
The invention disclosed is a total organic carbon (TOC) analyzer comprised of an electrochemical cell comprising a diamond-film electrode (2) doped with boron or other conductivity including...
6952060 Electromagnetic linear generator and shock absorber  
An electromagnetic linear generator and regenerative electromagnetic shock absorber is disclosed which converts variable frequency, repetitive intermittent linear displacement motion to useful...
6951827 Controlling surface chemistry on solid substrates  
By exposing precursor molecules traveling in a molecular beam to a narrow bandwidth laser beam (hu) tuned to a vibrational resonance frequency of the molecules and aimed orthogonal to the...
6951215 Drug delivery device for animals  
The invention features a drug delivery device which contains a cup-shaped body for enclosing a single external nare of a mammal but does not extend into the nostril of the mammal. The device is...
US20050215532 Tetracycline compounds for treatment of cryptosporidium parvum related disorders  
Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related...
US20050203027 Inhibitors of dipeptidylpeptidase IV  
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
US20050196317 Self-encoding sensor with microspheres  
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
6936118 Process of forming a composite coating on a substrate  
Precursor-based methods for the production of metal-matrix composite (MMC) coatings on steel and aluminum substrates for improved wear, corrosion and oxidation resistance have been made. Wire and...
US20050187198 Methods of preparing substituted tetracyclines with transition metal-based chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states....
US20050148551 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
US20050144663 Methods for cloning animals  
The present invention pertains to methods for cloning animals. In particular, the invention includes methods of cloning an animal by combining a genome from an activated donor cell with an...
US20050143353 13-Substituted methacycline compounds  
13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
US20050136075 Compositions and methods for bacterial immunity and secretion of proteins  
Attenuated strains of Gram negative bacteria carrying a mutation in one or more ysc genes or homologs are provided, as are methods of use for immunization against infection with a pathogenic...
US20050136062 Treatment of IgA1 deposition diseases  
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a...