Patents and Patent Applications from Tufts University


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US20120016209 FETAL ECG MONITORING  
A method for fetal monitoring includes acquiring electrical signals from a set of electrodes, for example, a set of surface electrodes applied to a maternal abdominal region. The electrical...
US20120016033 Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof  
Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH)...
8093217 Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers  
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of...
US20120004120 SELF-ENCODING SENSOR WITH MICROSPHERES  
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
US20110319398 INHIBITION OF YOPS TRANSLOCATION  
The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of...
US20110310384 METHODS AND SYSTEM FOR CONFOCAL LIGHT SCATTERING SPECTROSCOPIC IMAGING  
The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in...
US20110301127 METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
8071722 Silk biomaterials and methods of use thereof  
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer,...
US20110295277 HANDHELD SAFETY SUTURING DEVICE  
Needle-stick injuries are associated with considerable risk of morbidity for healthcare workers and patients. The present invention of a handheld surgical suturing device allows for visualization...
US20110294682 Polynucleotides Associated With Age-Related Macular Degeneration and Methods for Evaluating Patient Risks  
Disclosed are methods for diagnosing AMD or a susceptibility for AMD by identifying one or more markers associated with peripheral retinal phenotypes.
US20110293685 SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE  
The methods and compositions described herein relate to novel 3-dimensional porous scaffolds useful for tissue re-generation, enhancement, or tissue repair. Electrospinning or other methods are...
US20110285991 CHEMICAL/BIOLOGICAL SENSOR EMPLOYING SCATTERED CHROMATIC COMPONENTS IN NANO-PATTERNED APERIODIC SURFACES  
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting”...
US20110280847 METHODS AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORE GERMINATION AND OUTGROWTH  
Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C. difficile cells. The methods and...
US20110275788 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
US20110275538 MEASUREMENT OF BIOLOGICAL TARGETS  
An integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each...
US20110272348 IRON-MEDIATED REMEDIATION WITHIN NONAQUOUS PHASE LIQUID  
The present invention relates to remediation of hazardous waste sites. In particular, the present invention relates to compositions and methods for remediation of environmental contaminants in...
8053387 Catalyst having metal in reduced quantity and reduced cluster size  
The invention contemplates a method of making a catalytic material, and uses of the material. The catalytic material is made by depositing catalytic metals, such as gold or platinum, on substrate...
8048867 9-substituted minocycline compounds  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20110262971 Genetically Modified E. coli Strains for Producing Erythromycin  
Genetically modified E. coli strains capable of producing erythromycins, particularly erythromycin A.
US20110251105 METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
US20110251095 MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE  
An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix...
US20110245173 Long-Acting GLP-1 Derivatives, and Methods of Treating Cardiac Dysfunction  
The present invention generally provides polypeptide analogues of GLP-‘(9-34) and GLP-1 (9-36) that have increased in vivo half-lives resulting from reduced susceptibility to proteolytic enzymes....
8030094 Self-encoding sensor with microspheres  
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
US20110230747 IMPLANTABLE BIOMEDICAL DEVICES ON BIORESORBABLE SUBSTRATES  
Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to...
US20110223153 MODIFIED SILK FILMS CONTAINING GLYCEROL  
The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50%...
US20110218142 Inhibitors of Dipeptidylpeptidase IV  
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
8012951 7-N-substituted phenyl tetracycline compounds  
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
8012711 Methods of screening for compounds that reduce microbial resistance to fluoroquinolones  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
US20110206772 POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE  
The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a...
7998997 Inhibitors of fibroblast activation protein alpha  
Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic...
US20110195852 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION  
Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment,...
7994121 Stable analogs of peptide and polypeptide therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20110184283 SYSTEM AND METHOD OF CLINICAL TREATMENT PLANNING OF COMPLEX, MONTE CARLO-BASED BRACHYTHERAPY DOSE DISTRIBUTIONS  
A system, method, and computer program product of clinical treatment planning implements complex Monte Carlo (MC) based brachytherapy dose distributions using conventional brachytherapy treatment...
US20110184251 BONE MINERAL DENSITY RATIOS AS A PREDICTOR OF OSTEOARTHRITIS  
The present invention relates to systems, compositions, and methods for using bone mineral density ratios as a predictor of osteoarthritis. In particular, the present invention relates to...
US20110172519 SYSTEMS, DEVICES AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
US20110172311 Compounds For Treating Human Papillomavirus  
Methods and compositions for treating human papillomavirus infections are described.
US20110172149 Method of Regulating Glucose Metabolism, and Reagents Related Thereto  
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia,...
US20110171239 pH INDUCED SILK GELS AND USES THEREOF  
This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called...
US20110158980 METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY  
Described herein are methods for treating obesity or promoting weight loss using agents that alter pyruvate flux in an adipocyte. Methods are provided for administering an agent or combination of...
US20110152352 SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION  
The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention...
US20110152214 SILK POLYMER-BASED ADENOSINE RELEASE: THERAPEUTIC POTENTIAL FOR EPILEPSY  
This invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine, that provide for sustained, focal release of adenosine at therapeutic levels for the...
US20110150881 INHIBITORS OF EXTRACELLULAR HSP90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
US20110150775 GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS  
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
US20110138902 MEMS MICROPHONE ARRAY ON A CHIP  
The present invention relates to microelectromechanical systems (MEMS). In particular, the present invention relates to MEMS arrays for use in acoustics and other applications.
7962187 Optical imaging and oximetry of tissue  
Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of...
7960509 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
7959915 Inhibitors of extracellular Hsp90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
US20110135697 EDIBLE HOLOGRAPHIC SILK PRODUCTS  
The present invention relates to edible silk holographic elements and methods for making the same. Edible silk holographic elements are used to label pharmaceuticals and foods, or may be...
US20110132871 SHEAR SENSORS AND USES THEREOF  
The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing.
US20110129474 Methods And Systems For Multi-Antibody Therapies  
The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each...