Patents and Patent Applications from Tufts University


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US20110152352 SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION  
The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention...
US20110152214 SILK POLYMER-BASED ADENOSINE RELEASE: THERAPEUTIC POTENTIAL FOR EPILEPSY  
This invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine, that provide for sustained, focal release of adenosine at therapeutic levels for the...
US20110150881 INHIBITORS OF EXTRACELLULAR HSP90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
US20110150775 GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS  
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
US20110138902 MEMS MICROPHONE ARRAY ON A CHIP  
The present invention relates to microelectromechanical systems (MEMS). In particular, the present invention relates to MEMS arrays for use in acoustics and other applications.
7962187 Optical imaging and oximetry of tissue  
Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of...
7960509 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
7959915 Inhibitors of extracellular Hsp90  
The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention...
US20110135697 EDIBLE HOLOGRAPHIC SILK PRODUCTS  
The present invention relates to edible silk holographic elements and methods for making the same. Edible silk holographic elements are used to label pharmaceuticals and foods, or may be...
US20110132871 SHEAR SENSORS AND USES THEREOF  
The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing.
US20110129474 Methods And Systems For Multi-Antibody Therapies  
The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each...
7949389 Fetal ECG monitoring  
A method for fetal monitoring includes acquiring electrical signals from a set of electrodes, for example, a set of surface electrodes applied to a maternal abdominal region. The electrical...
US20110118215 7,8 And 9-Substituted Tetracycline Compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
US20110118125 NEONATAL SALIVARY GENOMICS  
The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or...
US20110110922 Wound Healing Peptides and Methods of Use Thereof  
Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial...
US20110109910 NON-INVASIVE OPTICAL CHARACTERIZATION OF BIOMATERIAL MINERALIZATION  
In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing...
US20110105855 EARLY DETECTION OF COGNITION IMPAIRMENT IN ELDERLY POPULATION  
We have discovered novel methods and systems for detecting cognitive impairment in a subject by analyzing the level of xantophylls in macula lutea or red blood cell sample from the subject. We...
US20110104653 INTERACTIVE DIGITAL WORKBOOK SYSTEM AND METHOD  
A digital workbook program, method, and system include a program interface module configured to communicate with a set of applications and a workbook module configured to generate a digital...
US20110104200 Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines  
Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the...
US20110092467 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds  
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates...
US20110089315 Optical Array Device and Methods of Use Thereof for Screening, Analysis and Manipulation of Particles  
Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A device parcels a light source into many...
US20110088586 Velocity control and terrain selection for gravity moderation  
A system, method, and apparatus is described for providing a reduced or moderated gravity environment in a terrestrial payload. The system includes the evaluation of terrain to support an...
US20110086821 Tetracycline Compounds for Treatment of Cryptosporidium Parvum Related Disorders  
Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related...
US20110082305 7-Phenyl-Substituted Tetracycline Compounds  
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
US20110082108 Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes  
The present invention relates to inhibitors of post-proline cleavage enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
US20110076384 SYSTEM AND METHOD FOR MAKING BIOMATERIAL STRUCTURES  
A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is...
7914769 Compounds for treating human papillomavirus  
Methods and compositions for treating human papillomavirus infections are described.
7910706 Humanized neutralizing antibodies against hemolytic uremic syndrome  
Novel human monoclonal antibodies derived from a transgenic mouse are disclosed as well as a process for the preparation of the novel monoclonals and a therapeutic method of treating an individual...
7910096 Human neutralizing antibodies against hemolytic uremic syndrome  
Human and humanized monoclonal antibodies which binds specifically to subunit A of Shiga like toxin II have been developed which are effective to prevent or ameliorate one or more symptoms of HUS...
7910095 Humanized neutralizing antibodies against hemolytic uremic syndrome  
Novel human monoclonal antibodies derived from a transgenic mouse are disclosed as well as a process for the preparation of the novel monoclonals and a therapeutic method of treating an individual...
US20110065123 Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression  
Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line...
US20110046686 3-DIMENSIONAL SILK HYDROXYAPATITE COMPOSITIONS  
Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and...
7875649 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
US20110015136 humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration  
Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential...
7871459 Apparatus and methods for non-regenerative and regenerative hot gas desulfurization  
Disclosed is a doped cerium oxide sorbent that can effectively and regenerably remove H2S in the temperature range of about 500° C. to about 1000° C. Regenerable sorbents (e.g., ZnO, La2O3, CeO2)...
US20110008906 Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss  
Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention.
US20100331406 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS  
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of,...
7858600 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds  
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates...
US20100317570 Composition and Method for the Treatment of Diseases Affected by a Peptide Receptor  
The present invention includes peptidomimetic compound compositions and methods of making and using peptidomimetic compounds to modulate the activity of a peptide receptor for the treatment of one...
7851460 7-phenyl-substituted tetracycline compounds  
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
US20100311770 COMPOUND COMBINATIONS FOR INHIBITING CELL DIVISION AND METHODS FOR THEIR IDENTIFICATION AND USE  
The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that...
7842780 Silk fibroin materials and use thereof  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...
US20100298540 Crystal Structure of a MarR Family Polypeptide  
The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
US20100294716 Templated Native Silk Smectic Gels  
One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous...
US20100292543 Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples  
Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue...
US20100292091 MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE  
An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix...
US20100286250 FLUORINATED LIPIDS AND METHODS OF USE  
The invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell.
7829530 Method of regulating glucose metabolism, and reagents related thereto  
One aspect of the present invention relates to a method for treating Type II diabetes in an animal, comprising conjointly administering to the animal metformin and an inhibitor of...
US20100279880 SELF-ENCODING SENSOR WITH MICROSPHERES  
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
US20100279112 SILK FIBROIN MATERIALS AND USE THEREOF  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...