Patents and Patent Applications from Tufts University


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US20120275979 SULFUR-TOLERANT WATER-GAS SHIFT CATALYSTS  
A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the...
8293931 7-N-substituted phenyl tetracycline compounds  
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
8293486 Functionalization of silk material by avidin-biotin interaction  
The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of...
US20120259211 SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
US20120259091 Apolipoprotein A1 Mimetics and Uses Thereof  
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
US20120258548 REDOX SENSOR  
Provided herein are devices, methods, and uses for measuring redox potential. For example, provided herein are fiber optic redox sensors and methods of use thereof.
8285076 Methods and apparatus for visual sub-band decomposition of signals  
Methods and apparatus for image processing include performing visual sub-band decomposition of an image using human visual system characteristics to generate a plurality of sub-band decomposed...
8285070 Methods and apparatus for image restoration  
Methods and apparatus for restoration of a digital image. In one embodiment, a method for repairing a defect in a digital image to provide a restored image comprises determining a plurality of...
US20120252120 DIAZONIUM SALT MODIFICATION OF SILK POLYMER  
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk...
8278344 Heterocyclic inhibitors of necroptosis  
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by...
US20120245221 ANTI-APOPTOTIC AGENTS AND USES THEREOF  
The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm...
US20120244143 DRAWN SILK EGEL FIBERS AND METHODS OF MAKING SAME  
The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is...
8268880 Soft protease inhibitors and pro-soft forms thereof  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
US20120232004 Methods for Treating Autoimmune Disorders, and Reagents Related Thereto  
The invention generally relates to improved methods for the treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple...
US20120232000 METHODS AND COMPOSITIONS FOR PROMOTING REGENERATION BY INCREASING INTRACELLULAR SODIUM CONCENTRATION  
The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell.
US20120226120 CARDIAC MONITORING  
A device for monitoring a heart includes a lead wire having a first end and a second end, the second end in contact with tissue of the heart; a first sensor disposed along the length of the lead...
US20120223293 Biodegradable Electronic Devices  
Biodegradable electronic devices may include a biodegradable semiconducting material and a biodegradable substrate layer for providing mechanical support to the biodegradable semiconducting material.
8258120 9-substituted minocycline compounds  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
8252777 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
8242173 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs  
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of,...
US20120201780 T. CRUZI-DERIVED NEUROTROPHIC AGENTS AND METHODS OF USE THEREFOR  
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
US20120195967 SILK-BASED DRUG DELIVERY SYSTEM  
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution...
US20120190578 Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes  
The present invention is directed to systems and method for predicting risk of AMD or a susceptibility to AMD in a patient by detecting elevated serum or plasma levels of C3, CFB or CFH and other...
US20120188640 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS  
The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk...
US20120187591 SILK NANOSPHERES AND MICROSPHERES AND METHODS OF MAKING SAME  
The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions...
US20120178901 NUCLEIC ACIDS ENCODING PEPTIDES FOR TREATING WOUNDS, ANTI-ANGIOGENIC COMPOUNDS AND USES THEREOF  
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides...
US20120178677 SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
8219180 System and method employing fiber optic shape tracking  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
8216568 Combination therapy with IgA1 proteases  
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a...
US20120171770 BIOENGINEERED SILK PROTEIN-BASED NUCLEIC ACID DELIVERY SYSTEMS  
Nucleic acid transfer is achieved using a silk-based delivery system which releases nucleic acids from silk-based complexes. The silk-based complexes, which are composed, for example, of plasmid...
US20120171256 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING  
The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications...
US20120165759 WATERPROOF STRETCHABLE OPTOELECTRONICS  
Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful...
US20120165252 Method of Regulating Glucose Metabolism, and Reagents Related Thereto  
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia,...
8206940 Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression  
Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line...
8206774 Diazonium salt modification of silk polymer  
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk...
8202695 Compositions, methods and kits for repressing virulence in gram positive bacteria  
Bacterial virulence is repressed by compositions and methods for activating permanently a repressor of virulence factors. Compositions provided contain at least one non-metabolizable analog of...
8195021 Biopolymer optical waveguide and method of manufacturing the same  
A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound...
US20120136033 Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof  
Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of...
8189191 Spectroscopic imaging microscopy  
Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light...
8187616 Method for silk fibroin gelation using sonication  
This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after...
US20120130044 Stable Analogs of Peptide and Polypeptide Therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20120129255 FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION  
The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of...
US20120128562 TREATING CATALYSTS  
A method includes contacting a catalyst including a metal having an average particle size of approximately one nanometer or greater with SO2; and reducing the average particle size of the metal.
US20120123519 TUBULAR SILK COMPOSITIONS AND METHODS OF USE THEREOF  
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily...
US20120121820 FABRICATION OF SILK FIBROIN PHOTONIC STRUCTURES BY NANOCONTACT IMPRINTING  
A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution,...
US20120121706 PAR-1 Activation by Metalloproteinase-1 (MMP-1)  
Matrix metalloproteases (MMPs) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention...
8178656 Silk-based drug delivery system  
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution...
US20120115175 METHODS FOR DIAGNOSING ELEVATED RIGHT OR LEFT VENTRICULAR FILLING PRESSURE  
The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a...
US20120114629 IGA1 PROTEASE POLYPEPTIDE AGENTS AND USES THEREOF  
Polypeptide agents useful in the treatment of IgA1 deposition diseases and methods of using such polypeptide agents. Methods of screening for inhibitors of IgA1 proteases and agents that inhibit...
8168810 7-phenyl-substituted tetracycline compounds  
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...