Patents and Patent Applications from Tufts University


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US20120190578 Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes  
The present invention is directed to systems and method for predicting risk of AMD or a susceptibility to AMD in a patient by detecting elevated serum or plasma levels of C3, CFB or CFH and other...
US20120188640 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS  
The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk...
US20120187591 SILK NANOSPHERES AND MICROSPHERES AND METHODS OF MAKING SAME  
The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions...
US20120178901 NUCLEIC ACIDS ENCODING PEPTIDES FOR TREATING WOUNDS, ANTI-ANGIOGENIC COMPOUNDS AND USES THEREOF  
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides...
US20120178677 SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
8219180 System and method employing fiber optic shape tracking  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
8216568 Combination therapy with IgA1 proteases  
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a...
US20120171770 BIOENGINEERED SILK PROTEIN-BASED NUCLEIC ACID DELIVERY SYSTEMS  
Nucleic acid transfer is achieved using a silk-based delivery system which releases nucleic acids from silk-based complexes. The silk-based complexes, which are composed, for example, of plasmid...
US20120171256 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING  
The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications...
US20120165759 WATERPROOF STRETCHABLE OPTOELECTRONICS  
Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful...
US20120165252 Method of Regulating Glucose Metabolism, and Reagents Related Thereto  
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia,...
8206940 Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression  
Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line...
8206774 Diazonium salt modification of silk polymer  
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk...
8202695 Compositions, methods and kits for repressing virulence in gram positive bacteria  
Bacterial virulence is repressed by compositions and methods for activating permanently a repressor of virulence factors. Compositions provided contain at least one non-metabolizable analog of...
8195021 Biopolymer optical waveguide and method of manufacturing the same  
A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound...
US20120136033 Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof  
Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of...
8189191 Spectroscopic imaging microscopy  
Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light...
8187616 Method for silk fibroin gelation using sonication  
This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after...
US20120130044 Stable Analogs of Peptide and Polypeptide Therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20120129255 FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION  
The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of...
US20120128562 TREATING CATALYSTS  
A method includes contacting a catalyst including a metal having an average particle size of approximately one nanometer or greater with SO2; and reducing the average particle size of the metal.
US20120123519 TUBULAR SILK COMPOSITIONS AND METHODS OF USE THEREOF  
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily...
US20120121820 FABRICATION OF SILK FIBROIN PHOTONIC STRUCTURES BY NANOCONTACT IMPRINTING  
A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution,...
US20120121706 PAR-1 Activation by Metalloproteinase-1 (MMP-1)  
Matrix metalloproteases (MMPs) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention...
8178656 Silk-based drug delivery system  
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution...
US20120115175 METHODS FOR DIAGNOSING ELEVATED RIGHT OR LEFT VENTRICULAR FILLING PRESSURE  
The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a...
US20120114629 IGA1 PROTEASE POLYPEPTIDE AGENTS AND USES THEREOF  
Polypeptide agents useful in the treatment of IgA1 deposition diseases and methods of using such polypeptide agents. Methods of screening for inhibitors of IgA1 proteases and agents that inhibit...
8168810 7-phenyl-substituted tetracycline compounds  
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
US20120101062 Lipase Inhibitors  
The present invention relates to inhibitors of lipases, such as inhibitors of endothelial lipase, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. The...
US20120095277 Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers  
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of...
8159288 Low power BPSK demodulator  
A low power BPSK demodulator having a simple architecture, compact design and reliable is provided. The BPSK demodulator includes a first branch (210) having a first mixer (212) and a first low...
US20120083676 FETAL ECG MONITORING  
A method for fetal monitoring includes acquiring electrical signals from a set of electrodes, for example, a set of surface electrodes applied to a maternal abdominal region. The electrical...
US20120077808 Niacin Mimetics, and Methods of Use Thereof  
Disclosed are heterocyclylalkyl-substituted and heteroaralkyl-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian...
US20120077807 NIACIN MIMETICS, AND METHODS OF USE THEREOF  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
US20120077779 Inhibitors of Fibroblast Activation Protein Alpha  
Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic...
US20120076771 SURFACE MODIFICATION OF SILK FIBROIN MATRICES WITH POLY(ETHYLENE GLYCOL) USEFUL AS ANTI-ADHESION BARRIERS AND ANTI-THROMBOTIC MATERIALS  
The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be...
US20120070427 VORTEX-INDUCED SILK FIBROIN GELATION FOR ENCAPSULATION AND DELIVERY  
The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk...
US20120064518 Methods, tip assemblies and kits for introducing material into cells  
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce...
US20120058117 NEUROPILIN-1 INHIBITORS  
The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies,...
8129141 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
US20120052124 SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY  
The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making...
8124580 Apolipoprotein A1 mimetics and uses thereof  
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
US20120046189 MARKERS RELATED TO AGE-RELATED MACULAR DEGENERATION AND USES THEREFOR  
Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers...
US20120045863 MICROPLASMA GENERATOR AND METHODS THEREFOR  
A low-temperature, atmospheric-pressure microplasma generator comprises at least one strip of metal on a dielectric substrate. A first end of the strip is connected to a ground plane and the...
8119622 7-phenyl-substituted tetracycline compounds  
7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the...
8114412 T. cruzi-derived neurotrophic agents and methods of use therefor  
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
US20120035403 CONVERTING BIOMASS TO GASEOUS FUEL HYDROCARBONS  
A method includes providing a solution containing a C2-6 carboxylic acid or a C2-6 carboxylate that is derived from biomass; and contacting the solution with a solid catalyst to form a C1-5...
US20120034291 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS  
The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale...
US20120029294 CANNULA  
A device for introducing surgical tools into a body is provided that a slotted cannula supported on a handle. The cannula is an elongate plate having a first end rigidly connected to an end of the...
8106225 Methods of preparing substituted tetracyclines with transition metal-based chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states....