Patents and Patent Applications from Tufts University


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US20120077807 NIACIN MIMETICS, AND METHODS OF USE THEREOF  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
US20120077779 Inhibitors of Fibroblast Activation Protein Alpha  
Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic...
US20120076771 SURFACE MODIFICATION OF SILK FIBROIN MATRICES WITH POLY(ETHYLENE GLYCOL) USEFUL AS ANTI-ADHESION BARRIERS AND ANTI-THROMBOTIC MATERIALS  
The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be...
US20120070427 VORTEX-INDUCED SILK FIBROIN GELATION FOR ENCAPSULATION AND DELIVERY  
The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk...
US20120064518 Methods, tip assemblies and kits for introducing material into cells  
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce...
US20120058117 NEUROPILIN-1 INHIBITORS  
The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies,...
8129141 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
US20120052124 SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY  
The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making...
8124580 Apolipoprotein A1 mimetics and uses thereof  
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
US20120045863 MICROPLASMA GENERATOR AND METHODS THEREFOR  
A low-temperature, atmospheric-pressure microplasma generator comprises at least one strip of metal on a dielectric substrate. A first end of the strip is connected to a ground plane and the...
8119622 7-phenyl-substituted tetracycline compounds  
7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the...
8114412 T. cruzi-derived neurotrophic agents and methods of use therefor  
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
US20120035403 CONVERTING BIOMASS TO GASEOUS FUEL HYDROCARBONS  
A method includes providing a solution containing a C2-6 carboxylic acid or a C2-6 carboxylate that is derived from biomass; and contacting the solution with a solid catalyst to form a C1-5...
US20120034291 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS  
The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale...
8106225 Methods of preparing substituted tetracyclines with transition metal-based chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states....
US20120016209 FETAL ECG MONITORING  
A method for fetal monitoring includes acquiring electrical signals from a set of electrodes, for example, a set of surface electrodes applied to a maternal abdominal region. The electrical...
US20120016033 Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof  
Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH)...
8093217 Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers  
Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of...
US20120004120 SELF-ENCODING SENSOR WITH MICROSPHERES  
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
US20110319398 INHIBITION OF YOPS TRANSLOCATION  
The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of...
US20110310384 METHODS AND SYSTEM FOR CONFOCAL LIGHT SCATTERING SPECTROSCOPIC IMAGING  
The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in...
US20110301127 METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
8071722 Silk biomaterials and methods of use thereof  
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer,...
US20110293685 SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE  
The methods and compositions described herein relate to novel 3-dimensional porous scaffolds useful for tissue re-generation, enhancement, or tissue repair. Electrospinning or other methods are...
US20110285991 CHEMICAL/BIOLOGICAL SENSOR EMPLOYING SCATTERED CHROMATIC COMPONENTS IN NANO-PATTERNED APERIODIC SURFACES  
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting”...
US20110280847 METHODS AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORE GERMINATION AND OUTGROWTH  
Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C. difficile cells. The methods and...
US20110275788 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
US20110275538 MEASUREMENT OF BIOLOGICAL TARGETS  
An integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each...
US20110272348 IRON-MEDIATED REMEDIATION WITHIN NONAQUOUS PHASE LIQUID  
The present invention relates to remediation of hazardous waste sites. In particular, the present invention relates to compositions and methods for remediation of environmental contaminants in...
8053387 Catalyst having metal in reduced quantity and reduced cluster size  
The invention contemplates a method of making a catalytic material, and uses of the material. The catalytic material is made by depositing catalytic metals, such as gold or platinum, on substrate...
8048867 9-substituted minocycline compounds  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20110262971 Genetically Modified E. coli Strains for Producing Erythromycin  
Genetically modified E. coli strains capable of producing erythromycins, particularly erythromycin A.
US20110251105 METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS  
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered...
US20110251095 MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE  
An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix...
US20110245173 Long-Acting GLP-1 Derivatives, and Methods of Treating Cardiac Dysfunction  
The present invention generally provides polypeptide analogues of GLP-‘(9-34) and GLP-1 (9-36) that have increased in vivo half-lives resulting from reduced susceptibility to proteolytic enzymes....
8030094 Self-encoding sensor with microspheres  
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
US20110230747 IMPLANTABLE BIOMEDICAL DEVICES ON BIORESORBABLE SUBSTRATES  
Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to...
US20110223153 MODIFIED SILK FILMS CONTAINING GLYCEROL  
The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50%...
US20110218142 Inhibitors of Dipeptidylpeptidase IV  
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using...
8012951 7-N-substituted phenyl tetracycline compounds  
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
8012711 Methods of screening for compounds that reduce microbial resistance to fluoroquinolones  
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
US20110206772 POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE  
The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a...
7998997 Inhibitors of fibroblast activation protein alpha  
Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic...
US20110195852 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION  
Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment,...
7994121 Stable analogs of peptide and polypeptide therapeutics  
The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
US20110172519 SYSTEMS, DEVICES AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
US20110172311 Compounds For Treating Human Papillomavirus  
Methods and compositions for treating human papillomavirus infections are described.
US20110172149 Method of Regulating Glucose Metabolism, and Reagents Related Thereto  
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia,...
US20110171239 pH INDUCED SILK GELS AND USES THEREOF  
This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called...
US20110158980 METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY  
Described herein are methods for treating obesity or promoting weight loss using agents that alter pyruvate flux in an adipocyte. Methods are provided for administering an agent or combination of...