Patents and Patent Applications from Tufts University


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US20130040838 METHODS FOR IDENTIFYING THE PRESENCE OF A BICUSPID AORTIC VALVE  
The present invention features a method for identifying a subject with a bicuspid aortic valve (BAV) by detecting one or more single nucleotide polymorphisms (SNPs) present in one or more...
US20130039986 Silk-Based Ionomeric Compositions  
Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can...
US20130035548 FIBER OPTIC INTUBATING DEVICE  
A fiberoptic intubating device is provided which permits visualization of the vocal cords and automatic deployment of an endotracheal tube into the trachea upon visualization. The device includes...
US20130029943 Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states....
8361617 Silk fibroin materials and use thereof  
The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk...
US20130023440 Polynucleotides Associated With Age-Related Macular Degeneration and Methods for Evaluating Patient Risk  
The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an...
8357655 Wound healing peptides and methods of use thereof  
Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial...
US20130018273 SYSTEMS AND METHODS FOR ANALYSIS OF FETAL HEART RATE DATA  
The present invention relates to systems and methods for analyzing fetal heart rate data. In particular, the present invention provides electronic rulers for use in analyzing fetal heart rate data.
8354501 Methods for stepwise deposition of silk fibroin coatings  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
8354378 G protein coupled receptor antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
US20130011841 Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss  
Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention.
8349326 Methods and systems for multi-antibody therapies  
The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each...
US20120325965 INFLATABLE AND RIGIDIZABLE SUPPORT ELEMENT  
The present invention provides novel inflatable and rigidizable support elements, and methods of manufacture and use thereof. In particular, the present invention provides inflatable and...
8339597 Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces  
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting”...
8338776 Optical array device and methods of use thereof for screening, analysis and manipulation of particles  
Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A device parcels a light source into many...
US20120316632 Retrievable covered stent for bifurcation aneurysms  
A retrievable covered stent has a self-expandable covered stent on the distal end and is particularly useful for occluding the neck of an aneurysm located in the vicinity of bifurcations or...
US20120310250 DEVICE FOR ASSISTING CESAREAN DELIVERIES  
A catheter device for facilitating release of a structure lodged within a body cavity includes a flexible catheter and carrier configured to mount the catheter to a finger. The catheter includes a...
US20120308611 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
8324182 Humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration  
Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential...
8324172 G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8318669 Method of regulating glucose metabolism, and reagents related thereto  
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of...
8318668 Stabilized GLP-1 analogs  
Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of...
US20120296256 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
An implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space. The device includes a shunt having opposed first and second ends. A one-way valve is located at...
US20120295346 METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR  
The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein....
US20120291335 Fish Livewell and Padding System Therefor  
This invention provides a livewell for storing and/or transporting live fish, and an insert for a livewell, including a padding system that is disposed between at least one wall of the tank one or...
US20120283201 9-SUBSTITUTED MINOCYCLINE COMPOUNDS  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20120276132 Atoxic recombinant holotoxins of Clostridium difficile as immunogens  
Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens...
US20120275979 SULFUR-TOLERANT WATER-GAS SHIFT CATALYSTS  
A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the...
8293931 7-N-substituted phenyl tetracycline compounds  
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
8293486 Functionalization of silk material by avidin-biotin interaction  
The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of...
US20120259211 SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING  
The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of...
US20120259091 Apolipoprotein A1 Mimetics and Uses Thereof  
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
US20120258548 REDOX SENSOR  
Provided herein are devices, methods, and uses for measuring redox potential. For example, provided herein are fiber optic redox sensors and methods of use thereof.
8285076 Methods and apparatus for visual sub-band decomposition of signals  
Methods and apparatus for image processing include performing visual sub-band decomposition of an image using human visual system characteristics to generate a plurality of sub-band decomposed...
8285070 Methods and apparatus for image restoration  
Methods and apparatus for restoration of a digital image. In one embodiment, a method for repairing a defect in a digital image to provide a restored image comprises determining a plurality of...
US20120252120 DIAZONIUM SALT MODIFICATION OF SILK POLYMER  
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk...
8278344 Heterocyclic inhibitors of necroptosis  
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by...
US20120245221 ANTI-APOPTOTIC AGENTS AND USES THEREOF  
The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm...
US20120244143 DRAWN SILK EGEL FIBERS AND METHODS OF MAKING SAME  
The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is...
8268880 Soft protease inhibitors and pro-soft forms thereof  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
US20120232004 Methods for Treating Autoimmune Disorders, and Reagents Related Thereto  
The invention generally relates to improved methods for the treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple...
US20120232000 METHODS AND COMPOSITIONS FOR PROMOTING REGENERATION BY INCREASING INTRACELLULAR SODIUM CONCENTRATION  
The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell.
US20120226120 CARDIAC MONITORING  
A device for monitoring a heart includes a lead wire having a first end and a second end, the second end in contact with tissue of the heart; a first sensor disposed along the length of the lead...
US20120223293 Biodegradable Electronic Devices  
Biodegradable electronic devices may include a biodegradable semiconducting material and a biodegradable substrate layer for providing mechanical support to the biodegradable semiconducting material.
8258120 9-substituted minocycline compounds  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
8252777 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
8242173 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs  
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of,...
US20120201780 T. CRUZI-DERIVED NEUROTROPHIC AGENTS AND METHODS OF USE THEREFOR  
The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based...
US20120195967 SILK-BASED DRUG DELIVERY SYSTEM  
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution...
US20120190578 Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes  
The present invention is directed to systems and method for predicting risk of AMD or a susceptibility to AMD in a patient by detecting elevated serum or plasma levels of C3, CFB or CFH and other...