Patents and Patent Applications from Tufts University


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US20130158131 SILK FIBROIN MATERIALS AND USE THEREOF  
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin...
US20130156844 METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
8466106 Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds and uses thereof  
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides...
US20130150292 Soft Protease Inhibitors and Pro-Soft Forms Thereof  
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active...
US20130149373 Compositions, methods and kits for modeling, diagnosing, and treating complement disorders  
Systems, compositions, methods, and kits for identifying potential therapeutic agents for treatment of complement based ocular diseases are provided herein. The methods and kits include a...
8460879 Methods and arrays for target analyte detection and determination of target analyte concentration in solution  
Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection...
8460878 Methods and arrays for detecting cells and cellular components in small defined volumes  
Arrays of single cells and methods of producing an array of single cells are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single cell capture, detection...
US20130144038 CRYSTAL STRUCTURE OF A MarR FAMILY POLYPEPTIDE  
The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
US20130143953 Compositions, kits and methods for treatment of complement-related disorders  
Methods, compositions and kits for regulating complement activity or treating a complement activity disorder in a subject using soluble, membrane-independent CD59 protein, methods of assaying...
US20130137102 Methods and kits for modulating tumor invasiveness and metastatic potential  
Methods and kits for evaluating invasive potential and metastatic potential of cancers by assessing Tiam1 expression levels in fibroblasts in the microenvironments surrounding tumors are provided.
8450316 Niacin mimetics, and methods of use thereof  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
8440627 G protein coupled receptor agonists and antagonists and methods of use  
The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in...
8440191 Clearance of abnormal IGA1 in IGA1 deposition diseases  
The present invention relates to proteins which specifically bind to IgA1 and which have been modified to comprise either O- or N-linked glycans. The invention encompasses methods for decreasing...
8437551 Devices and methods for restoring low-resolution text images  
A system that extracts text from an image includes a capture device that captures the image having a low resolution. An image segmentation subsystem partitions the image into image segments. An...
US20130108614 WOUND HEALING PEPTIDES AND METHODS OF USE THEREOF  
The current invention relates to methods and compositions for the treatment of wounds in a mammalian subject. Particularly, the invention relates to novel polypeptides and encoding nucleic acids...
8426217 Self-encoding sensor with microspheres  
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
8420884 Models of malignant brain cancer, and therapeutic siRNAs against oncogenic signaling pathways, and methods and kits for uses therefor  
Methods for screening compounds to treat an oncological disorder regulated through a tumor-inducing pathway are provided. The compounds are administered to non-human animal subjects having a...
8414903 Escherichia coli mutants and methods of use thereof  
The present invention provides methods and compositions for production of gram-negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by...
8411914 Systems and methods for spatio-temporal analysis  
High resolution time sequences of 3D images that show the dynamics of a time varying changes are provided. The 3D time series of images representing an object that include time varying changes may...
8410053 Methods for treating autoimmune disorders, and reagents related thereto  
The invention generally relates to improved methods for treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple...
8394736 Treating catalysts  
A method includes contacting a catalyst including a metal having an average particle size of approximately one nanometer or greater with SO2; and reducing the average particle size of the metal.
US20130060008 METHOD FOR SILK FIBROIN GELATION USING SONICATION  
This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after...
US20130058962 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
8389480 G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8377971 Non-flushing niacin analogues, and methods of use thereof  
One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the...
8377841 Catalyst having metal in reduced quantity and reduced cluster size  
The invention contemplates a method of making a catalytic material, and uses of the material. The catalytic material is made by depositing catalytic metals, such as gold or platinum, on substrate...
US20130040838 METHODS FOR IDENTIFYING THE PRESENCE OF A BICUSPID AORTIC VALVE  
The present invention features a method for identifying a subject with a bicuspid aortic valve (BAV) by detecting one or more single nucleotide polymorphisms (SNPs) present in one or more...
US20130039986 Silk-Based Ionomeric Compositions  
Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can...
US20130035548 FIBER OPTIC INTUBATING DEVICE  
A fiberoptic intubating device is provided which permits visualization of the vocal cords and automatic deployment of an endotracheal tube into the trachea upon visualization. The device includes...
US20130029943 Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries  
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states....
8361617 Silk fibroin materials and use thereof  
The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk...
US20130023440 Polynucleotides Associated With Age-Related Macular Degeneration and Methods for Evaluating Patient Risk  
The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an...
8357655 Wound healing peptides and methods of use thereof  
Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial...
US20130018273 SYSTEMS AND METHODS FOR ANALYSIS OF FETAL HEART RATE DATA  
The present invention relates to systems and methods for analyzing fetal heart rate data. In particular, the present invention provides electronic rulers for use in analyzing fetal heart rate data.
8354501 Methods for stepwise deposition of silk fibroin coatings  
The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any...
8354378 G protein coupled receptor antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8349326 Methods and systems for multi-antibody therapies  
The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each...
US20120325965 INFLATABLE AND RIGIDIZABLE SUPPORT ELEMENT  
The present invention provides novel inflatable and rigidizable support elements, and methods of manufacture and use thereof. In particular, the present invention provides inflatable and...
8339597 Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces  
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting”...
8338776 Optical array device and methods of use thereof for screening, analysis and manipulation of particles  
Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A device parcels a light source into many...
US20120316632 Retrievable covered stent for bifurcation aneurysms  
A retrievable covered stent has a self-expandable covered stent on the distal end and is particularly useful for occluding the neck of an aneurysm located in the vicinity of bifurcations or...
US20120310250 DEVICE FOR ASSISTING CESAREAN DELIVERIES  
A catheter device for facilitating release of a structure lodged within a body cavity includes a flexible catheter and carrier configured to mount the catheter to a finger. The catheter includes a...
US20120308611 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
8324182 Humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration  
Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential...
8324172 G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same  
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
8318669 Method of regulating glucose metabolism, and reagents related thereto  
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of...
8318668 Stabilized GLP-1 analogs  
Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of...
US20120296256 ENDOVASCULAR CEREBROSPINAL FLUID SHUNT  
An implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space. The device includes a shunt having opposed first and second ends. A one-way valve is located at...
US20120295346 METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR  
The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein....
US20120291335 Fish Livewell and Padding System Therefor  
This invention provides a livewell for storing and/or transporting live fish, and an insert for a livewell, including a padding system that is disposed between at least one wall of the tank one or...