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8168854 |
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals...
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US20120100116 |
NEURON GENERATION, REGENERATION AND PROTECTION
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...
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US20120064039 |
Use of Guanylyl Cyclase C Agonists to Suppress Appetite
Compositions comprising a guanylyl cyclase C agonist formulated for sustained specific release of an amount effective to suppress appetite when administered orally to an individual are disclosed....
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US20120015368 |
BIOMARKERS FOR EARLY DIAGNOSIS OF SYSTEMIC TISSUE FIBROSIS
Embodiments of the invention provides methods, devices and kits for determining the likelihood of an individual having an active fibrotic condition and/or early diagnosis, and subsequently...
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8067007 |
Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
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US20110260726 |
PHASE LABELING USING SENSITIVITY ENCODING: DATA ACQUISITION AND IMAGE RECONSTRUCTION FOR GEOMETRIC DISTORTION CORRECTION IN EPI
A phase labeling using sensitivity encoding system and method for correcting geometric distortion caused by magnetic field inhomogeneity in echo planar imaging (EPI) uses local phase shifts derived...
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US20110250228 |
Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of...
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US20110244570 |
VOLUME EXCLUSION AGENT TO ENHANCE FORMATION OF EXTRACELLULAR MATRIX
A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert...
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8021838 |
Transcriptional regulation of target genes
The present invention describes a method of identifying inducible genetic regulatory sequences that can control the transcription of specific gene transcripts. Methods of using inducible genetic...
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8021658 |
Alternative splice forms of proteins as basis for multiple therapeutic modalities
Peptides or antibodies derived from alternative splice forms of proteins associated with a disease or physiologic condition are used as therapeutic or prophylactic agents. Peptides and antibodies...
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US20110206736 |
Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same
Nucleic acid molecules comprising a nucleotide sequence that encodes a chimeric protein are disclosed. The chimeric proteins comprise at least one epitope of a mucosally restricted antigen, at...
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US20110195415 |
GUANYLYL CYCLASE C QRT-PCR
Methods, kits, compositions and systems for detecting the level of GCC encoding mRNA present in a sample using quantitative (q) RT-PCR are disclosed. The methods, kits, compositions and systems may...
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US20110184019 |
Long chain N-Alkyl compounds and oxa-derivatives thereof
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16...
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US20110104050 |
Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
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US20110086064 |
COMPOSITIONS AND METHODS FOR IDENTIFYING AND TARGETING CANCER CELLS OF ALIMENTARY CANAL ORIGIN
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of...
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US20110064764 |
Attenuated Live Triple G Protein Recombinant Rabies Virus Vaccine for Pre- and Post-Exposure Prophylaxis of Rabies
The invention provides a recombinant rabies viruses comprising three copies of a mutated G gene wherein each G gene encodes a rabies virus glycoprotein having the amino acid 194 mutated to a serine...
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US20110008344 |
FUSION PARTNER CELL LINE FOR PREPARATION OF HYBRID CELLS EXPRESSING HUMAN ANTIBODIES
This invention relates to a novel fusion partner cell line that ectopically expresses IL-6 and TERT termed B5-6T, and to methods for making the B5-6T fusion partner cell line. The B5-6T fusion...
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US20110002937 |
METHOD OF MAKING HYBRID CELLS THAT EXPRESS USEFUL ANTIBODIES
This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the...
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US20100297264 |
BOWEL PURGATIVE AND USES THEREOF
The present invention is directed to a dry composition for admixture with water for oral administration to a mammal and methods of using the composition for cleansing the bowel of a mammal in need...
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US20100285480 |
TCL-1 GENE AND PROTEIN AND RELATED METHODS AND COMPOSITIONS
The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The...
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7829276 |
Methods of using CRCA-1 as a stomach and esophageal cancer marker
Screening and diagnostic reagents, kits and methods for stomach or esophageal cancer are disclosed. Compounds, compositions and methods of treating patients with stomach or esophageal cancer and...
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US20100272711 |
COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES
The present invention is directed to a pharmaceutical composition, and methods of use thereof, comprising at least one agent which target multiple adenosine receptors (AR) simultaneously in a...
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7820390 |
Methods of and kits and compositions for diagnosing colorectal tumors
In vitro methods of determining whether or not an individual has metastasized colorectal cancer cells are disclosed. In vitro methods of determining whether or not tumor cells are colorectal in...
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7816560 |
Long chain n-alkyl compounds and oxa-derivatives thereof
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16...
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US20100247560 |
MUTANT BOTULINUM NEUROTOXIN SEROTYPE A POLYPEPTIDE AND USES THEREOF
Modified polypeptides based on the botulinum neurotoxin A heavy chain containing the double mutation Trp-Tyr->Leu-Ser in the ganglioside binding motif Ser-X-Trp-Tyr do not bind...
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US20100234241 |
DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused...
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US20100222555 |
Monoclonal antibodies that neutralize botulinum neurotoxin
This invention provides antibodies that specifically bind to botulinum neurotoxin type A (BoNT/A) and/or botulinum neurotoxin type B (BoNT/B) and the epitopes bound by those antibodies. The...
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US20100221290 |
MIXED HAPTENIZED TUMOR CELLS AND EXTRACTS AND METHODS OF TREATING OR SCREENING FOR CANCER
This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells,...
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7785817 |
Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of...
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7777005 |
Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The...
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US20100203544 |
DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER ASSOCIATED CHROMOSOMAL FEATURES
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused...
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US20100192235 |
HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA MODELED IN MOUSE BY TARGETED TCL1 EXPRESSION
Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals...
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US20100190840 |
TISSUE SPECIFIC GENE THERAPY TREATMENT
The invention provides nucleic acid segments, compositions and methods for the treatment of heart failure, vascular dysfunction, endothelial dysfunction, diabetes, [Ca2+]i regulation and NO...
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US20100173319 |
COMPOSITIONS AND METHODS FOR CANCER DIAGNOSIS AND THERAPY
The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate...
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7749715 |
TCL-1 gene and protein and related methods and compositions
The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The...
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7745114 |
Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of...
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7744870 |
ST receptor binding compounds and methods of using the same
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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US20100137365 |
Long chain N-alkyl compounds and oxa-derivatives thereof
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16...
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7728189 |
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals...
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7723035 |
Compositions and methods for cancer diagnosis and therapy
The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate...
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7723030 |
Diagnosis and treatment of cancers with microRNA located in or near cancer associated chromosomal features
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused...
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7695724 |
Recombinant rabies virus compositions
Recombinant rabies viruses in which the arginine residue of the glycoprotein (G) at amino acid position 333 is exchanged, renders these viruses nonpathogenic for immunocompetent mammals regardless...
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US20100056445 |
ADIPONECTIN FOR THE TREATMENT AND DIAGNOSIS OF ALBUMINURIA
Disclosed are methods relating to the treatment and/or prevention of kidney disorders, especially kidney disorders characterized by or involving albuminuria. Methods described include the...
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US20100048479 |
ADRENAL GRK2 ACTIVITY AS A THERAPEUTIC TARGET FOR HEART FAILURE
The present invention relates to compositions and methods for the treatment of failing hearts. More specifically, the present invention provides for the inhibition of G-protein coupled receptor...
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US20100047798 |
ADENOSINE A1 AND A3 RECEPTOR GENE SEQUENCE VARIATIONS FOR PREDICTING DISEASE OUTCOME AND TREATMENT OUTCOME
The present invention relates to methods for identify subjects for responsiveness to adenosine agonist treatment. Another aspect of the present invention relates to methods to predict a relative...
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US20100029570 |
PEPTIDE AND TREATMENT FOR HIV-1 INFECTION
A compound of the formula X1-M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X1-M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of...
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US20100029568 |
TIGHTER-BINDING C-PEPTIDE INHIBITORS OF HIV-1 ENTRY
The invention provides compositions and methods for the treatment of HIV infection, inhibition against drug-resistant strains of HIV-1 and methods of enhancing the anti-HIV potency of peptide...
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7655619 |
Insulin-associated peptides with effects on cerebral health
The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain...
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US20100021915 |
HIGH THROUGHPUT DNA SEQUENCING METHOD AND APPARATUS
The present invention relates to a method for high throughput nucleic acid sequencing using a multi-bead flow cell and pyrophosphate sequencing, a sequencer capable of performing this method, and a...
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US20100015167 |
COMPOSITIONS AND METHODS FOR IDENTIFYING AND TARGETING CANCER CELLS OF ALIMENTARY CANAL ORIGIN
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of...
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