Patents and Patent Applications from Thomas Jefferson University


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US20190351255 HEAD NECK IMMOBILIZATION WRAP  
An immobilization apparatus having at least one or more straps that engage a surface; wherein at least one of the straps comprises a force gauge to determine the amount of force applied to a...
US20190350468 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20190330532 HIGH TEMPERATURE BIO-CHAR CARBONIZATION AND MICRON GRINDING AND CLASSIFICATION FOR INCLUSION INTO MASTER BATCH POLYMERIZATION  
A thermal process for carbonizing hemp and reducing particle size, mechanically, by grinding or milling said carbonized hemp materials to generate a precise particle size hemp char and combining...
US20190330443 NANOCOMPOSITE HEMP  
A composite material comprising a polymer and a carbonized hemp filler, wherein the carbonized hemp filler is produced by carbonizing hemp at a temperature of at least 1100 C to produce a char;...
US20190330305 PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF  
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a...
US20190328678 NANOSPUN HEMP-BASED MATERIALS  
An antibacterial composite material comprising at least 10% of a hemp oil, said hemp oil comprising CBD at a concentration of at least 10 mg/ml and a polymer formed by a process wherein said hemp...
US20190313923 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20190307345 SIGNAL PROCESSING METHOD FOR DISTINGUISHING AND CHARACTERIZING HIGH-FREQUENCY OSCILLATIONS  
A device and a signal processing method that can be used with a device to recognize and distinguish a physiological high-frequency oscillation (HFO) from a pathological high-frequency oscillation....
US20190298184 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
10414814 Tumor-selective CTLA-4 antagonists  
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins...
10413200 Implantable vital sign sensor  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20190276395 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE  
Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive...
US20190264212 INHIBITING MICRORNA TO PREVENT DEVELOPMENT OF ESSENTIAL HYPERTENSION  
Therapeutic compositions and methods of treatment of the central nervous system, specifically towards hypertension comprising administration of a therapeutic comprising an anti-miR-135a, an...
US20190249262 LEVERAGING THE PRESENCE OR ABSENCE OF MIRNA ISOFORMS FOR RECOMMENDING THERAPY IN CANCER PATIENTS  
A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a...
US20190240164 Delivery Compositions, and Methods of Making and Using Same  
This invention provides compositions comprising at least one protein nanoparticle comprising a protein and a stealth polymer. In certain embodiments, the nanoparticle further comprises a...
10364279 PD-L1 and PD-L2-based fusion proteins and uses thereof  
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a...
10357571 Development of masked therapeutic antibodies to limit off-target effects  
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope...
10357509 Methods and compositions for treating cancers using antisense  
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be...
US20190201420 METHODS OF PREVENTION OR TREATMENT FOR PATHOLOGIC THROMBOSIS OR INFLAMMATION  
The present disclosure relates to methods of affecting platelet activation by the use of a PC-TP inhibitor. The PC-TP inhibitor can be administered to a subject in need thereof in order to prevent...
10335043 Implantable vital sign sensor  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20190192503 NOVEL METHODS OF TREATING A NEURODEGENERATIVE DISEASE IN A MAMMAL IN NEED THEREOF  
The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of...
US20190169245 CTLA4-BINDING PROTEIN PEPTIDE-LINKER MASKS  
Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding...
10292954 Composition and method for muscle repair and regeneration  
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a...
US20190135944 CELL BASED ANTI-CANCER COMPOSITIONS WITH REDUCED TOXICITY AND METHODS OF MAKING THE SAME  
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed....
US20190126043 IMPLANTABLE LIVING ELECTRODES AND METHODS FOR USE THEREOF  
In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the...
US20190125011 TEMPERATURE SENSITIVE SURGICAL FACE MASK FOR IDENTIFYING AT RISK PATIENTS AND REDUCING VIRAL INFECTION  
A disposable face mask that changes color as an indicator of fever to provide hospitals with a quick and inexpensive method for triaging infected patients while limiting exposure to others.
10266488 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase  
Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive...
10265339 Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory M2 monocytes  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
10258615 Methods of treating a neurodegenerative disease in a mammal in need thereof  
The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of...
US20190099618 TUMOR BED IMPLANT FOR MULTIMODALITY TREATMENT OF AT RISK TISSUE SURROUNDING A RESECTION CAVITY  
A device having a biocompatible polymer as a body and regularly spaced radiation seeds and regularly spaced magnetic materials disposed of within the body of the biocompatible polymer, or...
US20190099196 PUNCH TOOLS  
A tissue punch including a barrel defining a first open end, a second open end, and inner diameter, an outer diameter, and a lumen there through. A piston is at least partially disposed within the...
US20190062785 MULTIVALENT VACCINES FOR RABIES VIRUS AND CORONOVIRUSES  
The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus,...
10206942 Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory M2 monocytes  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
10202463 Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same  
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed....
US20190032111 FOUR-LEAF CLOVER QRT-PCR: AN EFFICIENT AND CONVENIENT METHOD FOR SELECTIVE QUANTIFICATION OF MATURE TRNA  
A method for quantifying individual mature tRNA species, comprising: incubating mature tRNA in a buffer to remove the amino acids from the 3′ end; annealing a DNA/RNA stem-loop adapter; ligating...
10172907 Compositions comprising β-arrestin 1 and methods of use thereof for therapeutic modulation of aldosterone levels in heart disease  
The invention concerns the contribution of elevated levels of circulating alsosterone to heart disease and other hyperaldosteronic conditions. Since activation of β-arrestin 1(βarr1) by the...
US20180370910 ANTIVIRAL AGENTS FOR AMANTADINE-RESISTANT INFLUENZA A  
An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating...
US20180353567 TREATMENT OF CARDIOVASCULAR DISEASE WITH COMPOUNDS THAT PROMOTE SELECTIVE INTERACTION OF THE B2-ADRENERGIC RECEPTOR WITH B-ARRESTIN  
A pharmaceutical composition and methods of administering the same for treatment of cardiovascular disease comprising a pepducin having a sequence SEQ ID No. 1, wherein said composition stimulates...
US20180320183 FUNCTIONAL TRANSFER tRNA-APTAMER MOLECULES  
The present invention provides functional aptamer-comprising tRNA molecules, useful in the study of tRNA and ribosomal activity.
US20180303976 COVALENT MODIFICATION OF DECELLULARIZED ALLOGENEIC GRAFTS WITH ACTIVE PHARMACEUTICALS  
A functionalized tissue having covalently bound antibiotics and methods for producing the functionalized tissue having bound antibiotics comprising; providing a tissue having a sufficient number...
US20180303830 CANCERS EXPRESSING CCR5 AND METHODS OF TREATMENT OF SAME  
Embodiments disclosed herein provide for methods of treating cancer and detecting CCR5 on circulating tumor cells and uses thereof based upon the same.
US20180297996 NON-SELECTIVE PROTEASE ACTIVATED RECEPTOR 4 ALA120THR ISOFORM ANTAGONIST  
A substance of Formula (I) for use as a medicament for the treatment of cardiovascular diseases, wherein R is nitrogen or carbon; R1 is selected from the group consisting of a hydrogen, a...
10085987 MCT protein inhibitor-related prognostic and therapeutic methods  
This invention provides a method of identifying one or more subgroups of cancer patients that are likely to benefit from treatment with a monocarboxylate transporter (MCT) protein inhibitor...
US20180271894 METHODS AND COMPOSITIONS FOR TREATING CANCERS AND ENHANCING THERAPEUTIC IMMUNITY BY SELECTIVELY REDUCING IMMUNOMODULATORY M2 MONOCYTES  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
US20180256625 METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE  
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be...
US20180251830 DUMBBELL- PCR: A METHOD TO QUANTIFY SPECIFIC SMALL RNA VARIANTS WITH A SINGLE NUCLEOTIDE RESOLUTION AT TERMINAL SEQUENCES  
A method for specifically and efficiently quantify the expression of targeted RNA variants with specific terminal sequences suitable to identify multiple isoforms bearing complex heterogeneity in...
US20180235996 Methods and Compositions for Treating Cancers and Enhancing Therapeutic Immunity by Selectively Reducing Immunomodulatory M2 Monocytes  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
US20180221527 INGSANITATION METHOD AND SYSTEM  
A sanitation system may include a sink, a sanitation material dispenser for dispensing material such as soap, and a dryer for either dispensing dryer material such as paper towels or providing...
US20180215806 TUMOR-SELECTIVE CTLA-4 ANTAGONISTS  
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins...
US20180214573 GENE THERAPIES FOR NEURODEGENERATIVE DISORDERS TARGETING GANGLIOSIDE BIOSYNTHETIC PATHWAYS  
A composition of matter comprising an adeno-associated virus (AAV) or other human compatible virus, encoding the gene for Sialidase Neu3, B3Galt4, St3Gal2, or combinations thereof, and a neuron...