Patents and Patent Applications from Thomas Jefferson University


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9789087 PAR4 inhibitor therapy for patients with PAR4 polymorphism  
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to...
9789074 Composition and method for muscle repair and regeneration  
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a...
9777055 Engineered antibody for inhibition of fibrosis  
A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy...
US20170268071 COMPOSITIONS AND METHODS OF USING TRANSFER RNAS (tRNAs)  
The present invention includes a method for analyzing tRNA fragments. In one aspect, the present invention includes Sa method of identifying a subject in need of therapeutic intervention to treat...
9750758 Compositions and methods for treating cancer with aberrant lipogenic signaling  
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high levels of SREBP1. Exemplary pinacolyl...
9750757 Methods of prevention or treatment for pathologic thrombosis or inflammation  
The present disclosure relates to methods of affecting platelet activation by the use of a PC-TP inhibitor. The PC-TP inhibitor can be administered to a subject in need thereof in order to prevent...
D795156 Wiper blade ornament  
US20170218074 DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS: APPLICATION TO ANTI-EGFR ANTIBODIES  
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope...
US20170175123 Diagnosis And Treatment Of Cancers With MicroRNA Located In Or Near Cancer-Associated Chromosomal Features  
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell...
US20170166593 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT LIPOGENIC SIGNALING  
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high levels of SREBP1.
9662405 Method of treating cancer by administering chimeric antigen receptor comprising anti-GCC antibody  
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the...
9657082 PD-L1 and PD-L2-based fusion proteins and uses thereof  
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a...
9629560 Implantable vital sign sensor  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170088597 INTERLEUKIN-15 SUPERAGONIST SIGNIFICANTLY ENHANCES GRAFT-VERSUS-TUMOR ACTIVITY  
The invention features therapies using an IL-15-based superagonist complex to effectively treat subjects with cancer.
US20170065188 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170065186 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170056565 ANTIBIOTIC DRUG RELEASE SHEATH  
An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is...
US20170056430 Methods and Compositions for Treating Cancers and Enhancing Therapeutic Immunity by Selectively Reducing Immunomodulatory M2 Monocytes  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
US20170049869 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
9574206 Engineered biomass with increased oil production  
The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified...
US20170035734 PAR4 INHIBITOR THERAPY FOR PATIENTS WITH PAR4 POLYMORPHISM  
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to...
US20170009295 NOVEL HUMAN MIRNAS FOR USE IN DIAGNOSIS, PROGNOSIS, AND THERAPY OF HUMAN CONDITIONS AND DISEASES  
Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of...
US20170001955 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase  
Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive...
US20160362688 COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS  
The present invention provides compositions and methods of making and using microRNA inhibitors. In a particular embodiment, the invention features compositions and methods useful for the...
US20160347846 FUSION PROTEINS FOR MODULATING REGULATORY AND EFFECTOR T CELLS  
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention...
9506065 Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features  
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell...
US20160304624 Cell-Based Anti-Cancer Compositions With Reduced Toxicity and Methods of Making and Using the Same  
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed....
US20160303107 NOVEL METHODS OF TREATING A NEURODEGENERATIVE DISEASE IN A MAMMAL IN NEED THEREOF  
The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of...
US20160287174 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20160287094 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20160271150 METHODS OF PREVENTION OR TREATMENT FOR PATHOLOGIC THROMBOSIS OR INFLAMMATION  
The present disclosure relates to methods of affecting platelet activation by the use of a PC-TP inhibitor. The PC-TP inhibitor can be administered to a subject in need thereof in order to prevent...
9447146 Guanylylcyclase C ligands  
Guanylin cyclase C compound of the inventions are disclosed. Conjugated compounds comprising guanylin cyclase C compound of the inventions conjugated to detectable or therapeutic moieties are...
9439912 Androgen receptor down-regulating agents and uses thereof  
The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds...
9429576 Compositions and methods for identifying and targeting cancer cells of alimentary canal origin  
Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
US20160216251 E2F REPORTER MELANOMA CELLS  
A modified melanoma cell line capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.
US20160215002 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT LIPOGENIC SIGNALING  
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high levels of SREBP 1.
US20160213777 Novel Delivery Compositions and Methods of Using Same  
This invention provides compositions comprising at least one protein nanoparticle comprising a protein and a non-ionic surfactant. In certain embodiments, the nanoparticle further comprises a...
9393268 Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same  
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed....
US20160192948 ANGLED CRANIOTOME AND MINIMAL PLATING SYSTEM FOR IMPROVED COSMESIS AND STRUCTURAL INTEGRITY OF CRANIOTOMIES  
In accordance with one embodiment, a device for performing an angled craniotome includes an elongate handle, a footplate, a stem, and an elongate cutting bit. The elongate handle extends in a...
US20160152711 DESIGN AND DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS: APPLICATION TO ANTI-EGFR ANTIBODIES  
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope...
US20160139132 Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm  
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate,...
US20160120457 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR VISUALIZATION OF RESECTION TARGET DURING EPILEPSY SURGERY AND FOR REAL TIME SPATIOTEMPORAL VISUALIZATION OF NEUROPHYSIOLOGIC BIOMARKERS  
The subject matter described herein relates to methods, systems, and computer readable media for visualization of a resection target during epilepsy surgery and for real time spatiotemporal...
9314439 Composition and method for muscle repair and regeneration  
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a...
US20160074389 CAVEOLIN-1 RELATED METHODS FOR TREATING GLIOBLASTOMA WITH TEMOZOLOMIDE  
This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temoxolomide to be glioblastoma...
US20160059036 SURFACTANT MICROBUBBLES AND PROCESS FOR PREPARING AND METHODS OF USING THE SAME  
The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a...
9273133 Compositions and methods for the treatment and prevention of lens fibrotic diseases  
Compositions and methods for treating fibrotic diseases are provided.
US20160041170 METHOD FOR DETECTING SHED OR CIRCULATING TUMOR CELLS IN BIOLOGICAL FLUIDS  
This invention relates to a method for detecting shed or circulating tumor cells in a biological fluid using labeled pituitary adenylate cyclase activating peptide or vasoactive intestinal peptide.
US20160038526 TREATMENT OF PROSTATE CANCER  
Prostate cancer is treated by administration of N6-benzyladenosine-5′-monophosphate or pharmaceutically acceptable salt thereof.
US20160030595 ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS  
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the...
9249194 Neuron generation, regeneration and protection  
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...