Patents and Patent Applications from Thomas Jefferson University


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US20180201939 METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE  
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be...
10022506 Hypodermic injection device incorporated in a case for a portable electronic device  
A hypodermic injection device configured to be attached to a portable electronic device is disclosed herein. The hypodermic injection device can be an auto-injector for delivering a dose of an...
10022372 Caveolin-1 related methods for treating glioblastoma with temozolomide  
This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temoxolomide to be glioblastoma...
10022134 Angled craniotome and minimal plating system for improved cosmesis and structural integrity of craniotomies  
In accordance with one embodiment, a device for performing an angled craniotome includes an elongate handle, a footplate, a stem, and an elongate cutting bit. The elongate handle extends in a...
US20180185445 EFFECT OF HEMOPEXIN THERAPY AFTER INTRACEREBRAL HEMORRHAGE  
A method for providing perihematomal protection to a patient after suffering an ICH comprising administering an effective amount of Hx to said patient to increase serum concentrations to between...
US20180180594 E2F REPORTER MELANOMA CELLS  
A modified melanoma cell line capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.
US20180180593 MEASURING FREQUENCY OF PATHOGEN-SPECIFIC T CELLS IN PERIPHERAL BLOOD  
A method for detecting and quantifying of the frequency of T cells to multiple antigenic peptide epitopes comprising: measuring intracellular Ca2+ signaling in individual T cells that are labeled...
9988403 Compositions and methods for treating cancer with aberrant lipogenic signaling  
The technology described herein relates to dimethyl boronate esters of the following formula for the treatment of cancers expressing abnormally high levels of SREBP1:
US20180148512 FUSION PROTEINS THAT FACILITATE CANCER CELL DESTRUCTION  
Provided is a fusion protein comprising a polypeptide component that blocks binding of CD47 to SIRP alpha and a polypeptide that binds to and triggers a TRAIL receptor or Fas. Also provided is a...
US20180125399 LONG-TERM IMPLANTABLE MONITORING SYSTEM & METHODS OF USE  
Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The...
9950097 Multifunctional chitosan grafted surfaces and uses thereof  
The invention relates to a multifunctional chitosan grafted surface. Specifically, the invention relates to a chitosan modified with a quaternary ammonium salt (CH-Q) grafted surface that provides...
US20180079821 Fusion Proteins for Modulating Regulatory and Effector T Cells  
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. The proteins of the invention are useful in...
US20180072799 ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS  
A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy...
US20180057561 PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF  
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a...
9889192 Immunization with rabies virus vector expressing foreign protein antigen  
An immune response in a subject is elicited by a regiment comprising immunization with an attenuated recombinant rabies virus encoding at least one foreign protein antigen, and booster...
9884067 Androgen receptor down-regulating agents and uses thereof  
The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds...
9880150 E2F reporter melanoma cells  
A method of using a modified melanoma cell capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in...
9873747 Fusion proteins that facilitate cancer cell destruction  
Provided is a fusion protein comprising a polypeptide component that blocks binding of CD47 to SIRP alpha and a polypeptide that binds to and triggers a TRAIL receptor or Fas. Also provided is a...
US20180000784 PAR4 INHIBITOR THERAPY FOR PATIENTS WITH PAR4 POLYMORPHISM  
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to...
US20180000762 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION  
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a...
US20170360821 TREATMENT AND PREVENTION OF THROMBOSIS USING AN ANTI-MIR  
Disclosed are anti-miR compositions and methods of use of the same for treatment of or reducing the occurrence of thrombosis and thrombosis related diseases and disorders by reducing platelet...
US20170360312 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
9834610 Fusion proteins for modulating regulatory and effector T cells  
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention...
9814413 Long-term implantable monitoring system and methods of use  
Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The...
US20170314076 SPECIFIC EXPRESSION OF HALF-TRNA IN CANCERS  
The present invention relates to systems, devices and methods for diagnosing cancer. In various embodiments, the present invention provides a method for quantifying a 5′-htRNA; a method for...
9789087 PAR4 inhibitor therapy for patients with PAR4 polymorphism  
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to...
9789074 Composition and method for muscle repair and regeneration  
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a...
9777055 Engineered antibody for inhibition of fibrosis  
A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy...
US20170268071 COMPOSITIONS AND METHODS OF USING TRANSFER RNAS (tRNAs)  
The present invention includes a method for analyzing tRNA fragments. In one aspect, the present invention includes Sa method of identifying a subject in need of therapeutic intervention to treat...
9750758 Compositions and methods for treating cancer with aberrant lipogenic signaling  
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high levels of SREBP1. Exemplary pinacolyl...
9750757 Methods of prevention or treatment for pathologic thrombosis or inflammation  
The present disclosure relates to methods of affecting platelet activation by the use of a PC-TP inhibitor. The PC-TP inhibitor can be administered to a subject in need thereof in order to prevent...
D795156 Wiper blade ornament  
US20170218074 DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS: APPLICATION TO ANTI-EGFR ANTIBODIES  
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope...
US20170175123 Diagnosis And Treatment Of Cancers With MicroRNA Located In Or Near Cancer-Associated Chromosomal Features  
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell...
US20170166593 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT LIPOGENIC SIGNALING  
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high levels of SREBP1.
9662405 Method of treating cancer by administering chimeric antigen receptor comprising anti-GCC antibody  
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the...
9657082 PD-L1 and PD-L2-based fusion proteins and uses thereof  
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a...
9629560 Implantable vital sign sensor  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170088597 INTERLEUKIN-15 SUPERAGONIST SIGNIFICANTLY ENHANCES GRAFT-VERSUS-TUMOR ACTIVITY  
The invention features therapies using an IL-15-based superagonist complex to effectively treat subjects with cancer.
US20170065188 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170065186 IMPLANTABLE VITAL SIGN SENSOR  
An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through,...
US20170056565 ANTIBIOTIC DRUG RELEASE SHEATH  
An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is...
US20170056430 Methods and Compositions for Treating Cancers and Enhancing Therapeutic Immunity by Selectively Reducing Immunomodulatory M2 Monocytes  
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the...
US20170049869 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
9574206 Engineered biomass with increased oil production  
The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified...
US20170035734 PAR4 INHIBITOR THERAPY FOR PATIENTS WITH PAR4 POLYMORPHISM  
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to...
US20170009295 NOVEL HUMAN MIRNAS FOR USE IN DIAGNOSIS, PROGNOSIS, AND THERAPY OF HUMAN CONDITIONS AND DISEASES  
Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of...
US20170001955 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase  
Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive...
US20160362688 COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS  
The present invention provides compositions and methods of making and using microRNA inhibitors. In a particular embodiment, the invention features compositions and methods useful for the...
US20160347846 FUSION PROTEINS FOR MODULATING REGULATORY AND EFFECTOR T CELLS  
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention...