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8183048 |
Assay for screening/ranking antioxidants based on their effects on membrane sterol lateral organization
A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of...
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US20120122987 |
TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35)
Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke...
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8173023 |
Method and apparatus for treatment of a fluid
An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the...
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US20120108504 |
LEPTIN AGONIST AND METHODS OF USE
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance,...
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8156954 |
Method for reduction of crude oil viscosity
The present invention relates to a method for reducing the viscosity and facilitating the flow of petroleum-based fluids. The method includes the step of applying an electric field of sufficient...
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8143453 |
Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, su...
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8143428 |
Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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8143213 |
Effect of TULA on HIV
A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a fragment of TULA containing a UBA domain, a...
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US20120024044 |
SYSTEMS AND METHODS FOR DETECTING CONCEALED NUCLEAR MATERIAL
Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of...
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8106033 |
Composition and methods for the treatment of proliferative diseases
Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group...
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US20120021130 |
METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL
This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of...
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US20120017467 |
ORTHOTIC SHOE AND INSOLE ASSEMBLIES
An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via...
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US20110294698 |
PROCESS FOR IDENTIFYING DRUGS FOR TREATING GASTROESOPHAGEAL REFLUX
Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to...
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8067461 |
3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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US20110288021 |
ADMINISTRATION OF ANGIOCIDIN FOR THE TREATMENT OF CANCER
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest...
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8059816 |
Secret sharing technique with low overhead information content
An apparatus and method for sharing a secret comprising the steps of generating a first random matrix, generating a first projection matrix from the first random matrix, and determining a first...
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8058313 |
Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
α,β-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1, R2, M1, M2, L, E1, E2, Q1, Q2 and n are as defined herein, are u...
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US20110274611 |
PURIFICATION OF SINGLE WALLED CARBON NANOTUBES BY DYNAMIC ANNEALING
A method for removing impurities from carbon nanotubes is described. Impurities may be removed from the carbon nanotubes by exposing the carbon nanotubes to a temperature, and controlling the...
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US20110251614 |
LOCKING ROD FUSION DEVICE
A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a...
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8034011 |
Thoracic stabilizer
A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and...
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US20110184171 |
ACYLATION OF HINDERED AMINES AND FUNCTIONALIZED BIS-PEPTIDES OBTAINED THEREBY
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures...
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7981674 |
Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation
The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding...
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US20110162646 |
PROCESS FOR TRANSIENT AND STEADY STATE DELIVERY OF BIOLOGICAL AGENTS TO THE LUNG VIA BREATHABLE LIQUIDS
The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering...
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7932242 |
Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
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7909031 |
Process for transient and steady state delivery of biological agents to the lung via breathable liquids
The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering...
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US20110031122 |
METHOD FOR DETECTING DISEASE MARKERS
Disease specific markers, in particular cancer markers, can be detected by electrophoretically separating proteins and protein complexes from a biological sample on a protein binding polymeric...
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US20110015124 |
LEPTIN AGONIST AND METHODS OF USE
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related...
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US20100323951 |
ANTIBACTERIAL PEPTIDES ACTIVE IN SYSTEMIC INFECTIONS
Antimicrobial peptides of the formula are provided: X1—X2—PrO—X3—X4—PrO-Arg-Pro-Tyr-Leu-Pro-X5-Pro-Arg
-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino gro...
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US20100321767 |
METHODS AND DEVICES FOR GENERATION OF BROADBAND PULSED RADIATION
Methods and apparatus for non-collinear optical parametric ampliffication (NOPA) are provided. Broadband phase matching is achieved with a non-collinear geometry and a divergent signal seed to...
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US20100305059 |
COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is...
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US20100291687 |
AN ASSAY FOR SCREENING/RANKING ANTIOXIDANTS BASED ON THEIR EFFECTS ON MEMBRANE STEROL LATERAL ORGANIZATION
A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of...
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US20100291595 |
BLOOD MONOCYTE CD163 EXPRESSION AS A BIOMARKER IN HIV-1 INFECTION AND NEUROAIDS
The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting...
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US20100284921 |
TARGETED NANOPARTICLES FOR INTRACELLULAR CANCER THERAPY
This invention provides constructs comprising a targeting member immobilized on a detectable particulate, in which binding of the targeting member to a target structure on a surface of a cancer...
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US20100204673 |
OBESITY CONTROLLING METHOD
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7744889 |
Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
αβ-Unsaturated sulfoxides of Formula I: are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
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7737109 |
Obesity controlling method
A method of controlling obesity by physically narrowing the lumen of the pylorus One embodiment includes injection of a bio-compatible bulking or stiffening material into the pyloric sphincter area...
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US20100136036 |
UNCONVENTIONAL ANTIGEN TRANSLATED BY A NOVEL INTERNAL RIBOSOME ENTRY SITE ELICITS ANTITUMOR HUMORAL IMMUNE REACTIONS
The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the...
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US20100036395 |
METHOD AND APPARATUS OF ENDOSCOPIC SUTURING
An adjustable suture assembly is provided that may be employed in various surgical procedures to draw and/or hold tissue and/or muscle together. The suture assembly may include a suture lock or...
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US20100028368 |
SULFIDE, SULFOXIDE AND SULFONE CHALCONE ANALOGUES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF
Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of...
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US20100024783 |
ELECTRIC-FIELD ASSISTED FUEL ATOMIZATION SYSTEM AND METHODS OF USE
An apparatus (100) for reducing the size of fuel particles injected into a combustion chamber is disclosed. The apparatus includes fuel line (110), a first metallic mesh (114) disposed within the...
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US20100012122 |
OPEN-CIRCUIT LIQUID VENTILATOR
An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable liquid...
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US20100008505 |
Secret sharing technique with low overhead information content
An apparatus and method for sharing a secret comprising the steps of generating a first random matrix, generating a first projection matrix from the first random matrix, and determining a first...
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7635561 |
Methods of diagnosing, prognosing and treating breast cancer
The protein pRb2/p130 represses expression of the ER-α gene. Blocking pRb2/p130 expression or altering ER-α gene methylation to alter pRb2/p130 complex binding allows transcriptional activity of t...
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US20090304736 |
NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA
The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame...
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US20090281066 |
Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones
Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
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US20090275650 |
3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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7612039 |
Method of cell growth inhibition with agnoprotein
The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the...
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7608578 |
Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7598232 |
Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2,R3, R4, R5, R6, R7, g, M, y, a, b, d,...
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7595347 |
Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone c...
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