Patents and Patent Applications from Temple University


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US20170349628 Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications  
The present invention provides a novel cell penetrating peptide that transports proteins into cells and/or into nuclei and a pharmaceutical containing the peptide.
US20170347915 Magnetometer Surgical Device  
A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned...
9828458 Silica particles coated with β-cyclodextrin for the removal of emerging contaminants from wastewater  
Provided is a silica particle coated with β-cyclodextrin, wherein said cyclodextrin is attached to said silica particle via at least one crosslinking agent and/or at least one copolymer. Also...
US20170333572 RNA GUIDED ERADICATION OF HUMAN JC VIRUS AND OTHER POLYOMAVIRUSES  
The present invention includes methods and compositions for elimination of polyomaviruses, such as John Cunningham Virus (JVC), from host cells, and the treatment of polyomavirus related diseases,...
US20170332911 APPARATUS AND METHOD FOR SURFACE AND SUBSURFACE TACTILE SENSATION IMAGING  
A tactile sensor, computer readable medium, methods of using and manufacturing the tactile sensor, and methods and apparatuses for processing the information generated by the tactile sensor. The...
9814756 Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium  
A method for treatment of a subject having an inflammatory disease of the epithelium comprising the step of administering an amount of a composition comprising an isolated bacterial amyloid...
9802924 5-hydroxytryptamine receptor 7 activity modulators and their method of use  
Pharmaceiiticai compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
9795642 Enterococcus faecalis bacteriophage and uses thereof  
Bacteriophages are provided that infect strains of Enterococcus faecalis, an opportunistic bacterial pathogen that causes human disease. Also provided are methods of treating Enterococcus faecalis...
US20170298037 Novel 5-Hydroxytryptamine Receptor 7 Activity Modulators and Their Method of Use  
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
US20170290806 PCSK9 Inhibitors and Methods of Use Thereof  
The present invention relates to compositions and methods for treating lipid disorders in a subject. In one embodiment, the compositions of the present invention can be used to inhibit protease...
9763894 Inflammation therapy  
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
US20170253814 REMOVAL OF IRON CONTAMINANTS FROM HYDROCARBON OILS AND AQUEOUS BY-PRODUCTS OF OIL AND GAS RECOVERY/PRODUCTION  
Iron contaminants are removed from hydrocarbon oils, and from produced water or flowback water by-products of oil and gas production, by treatment of such liquids with a composition comprising a...
US20170246139 SYNERGISTIC COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS  
Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein...
9730961 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
9724304 Nanospheres for therapeutic agent delivery  
Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or...
US20170204151 Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for Treating Diseases and Disorders  
Isolated mesenchymal stem cells, which produce mRNA encoding TSG-6 protein or a biologically active fragment, derivative, or analogue thereof in an amount of at least a first preselected amount,...
US20170203009 Biomimetic Scaffold for Regenerative Dentistry  
The present invention relates to biomimetic scaffolds, methods for making the same, and methods for using the same. The scaffolds comprise a plurality of graded or tapered microchannels that...
9693999 Small molecule RNase inhibitors and methods of use  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
9688715 Synthetic pGpG analogs, methods of preparation and methods of use  
The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, and L are as defined herein. Methods for preparing compounds of Formula I are also...
9687816 Method of regeneration of beta-cyclodextrin based adsorbent-coated silica with ozone  
The present invention relates to systems and methods for regenerating β-cyclodextrin (β-CD) adsorbent after it has been used in a water decontamination process. The regeneration process of the...
US20170179524 Soft-Solid Crystalline Electrolyte Compositions And Methods For Producing The Same  
The present invention relates to compositions comprising ionic compounds surrounded by organic matrices, and methods for producing such compositions. In various embodiments, the compositions of...
US20170176408 Detection of HIV-1-Associated Neurocognitive Disorders  
Provided is a method of detecting mild neurocognitive disturbance (MNCD) or HIV associated dementia (HAD) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine...
US20170174734 DR6 Receptor Mediates the Leukemia Differentiation Activity of Angiocidin: A Potent Anti-Tumor Peptide  
The present invention provides compositions and methods of treating cancer by inducing the cellular differentiation activity of angiocidin.
9680182 Solid polymer electrolyte composition for lithium ion battery  
A composition suitable as a solid polymer electrolyte for a lithium ion battery comprises a mixture of polyoctahedral silsesquioxane-phenyl7(BF3Li)3 and a poly(ethylene oxide).
US20170145385 Mesenchymal Stem Cells Derived From Induced Pluripotent Stem Cells  
A method of producing mesenchymal stem cells from induced pluripotent stem cells in which induced pluripotent stem cells are cultured in the presence of a TGF-βinhibitor an in an atmosphere...
9652696 Apparatus and method for surface and subsurface tactile sensation imaging  
A tactile sensor, computer readable medium, methods of using and manufacturing the tactile sensor, and methods and apparatuses for processing the information generated by the tactile sensor. The...
US20170128525 Administration of Angiocidin for the Treatment of Cancer  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth...
9622995 Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)  
Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke...
US20170078584 OPTICAL DYNAMIC IMAGING SYSTEM  
The dynamic positioning of sensors, which exploit the mechanical and physiological changes in tissues, can significantly increase the performance in characterization of tumors. Here, we disclose...
9585380 SSAT mRNA translation repression and activation  
The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has...
US20170042820 Calcium Alginate Dosage Formulations, and Methods of Making and Using Thereof  
An alginate and stearic acid composition is described, including methods of molding it into tablets further comprising a drug, and methods of controlling the drug release from the tablets.
US20170016066 BAG3 AS A TARGET FOR THERAPY OF HEART FAILURE  
Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for...
US20170014878 Method Of Remediation Of Organic Toxins Using Supported Lipid Bilayer Nanoparticles  
The present invention relates to methods and compositions for water treatment and environmental remediation using nanoparticle supported lipid bilayers (NP-SLBs). In one embodiment, the NP-SLBs...
US20170014355 CANNABINOID RECEPTOR TREATMENTS  
The present invention includes methods and compositions for treating a transplant recipient by administration of a CB2 receptor agonist either alone or in combination with one or more active...
9545428 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
9526758 Administration of angiocidin for arresting the growth of a tumor cell  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth...
US20160367967 Method of Regeneration of Beta-Cyclodextrin Based Adsorbent-Coated Silica With Ozone  
The present invention relates to systems and methods for regenerating β-cyclodextrin (β-CD) adsorbent after it has been used in a water decontamination process. The regeneration process of the...
9517230 Small molecule RNase inhibitors and methods of use  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20160343483 Non-Joulian Magnetostrictive Materials and Method of Making the Same  
The invention relates to non-Joulian magnetostriction (NJM) materials comprising transition metals, such as iron alloy magnets with non-Joulian magnetostriction (NJM). The invention also relates...
9464062 Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators  
Pharmaceutical compositions of the invention comprise disubstituted oxazolidin-2-ones derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
US20160278375 BISCATIONIC AND TRISCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS  
The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and...
US20160262384 POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS  
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The...
US20160257672 FUNCTIONALIZED FURAN-2-SULFONAMIDES EXHIBITING ENDOTHELIAL LIPASE INHIBITION  
The present invention relates to pharmaceutical compositions comprising furan-2-sulfonamide derivatives. The present invention further relates to methods of treatment of diseases or conditions...
US20160250300 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION  
A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly...
US20160242413 POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS  
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The...
US20160235789 Bone Marrow Origin Progenitor Cell or Endothelial Progenitor Cell in Combination with DNMT1 Gene Therapy for Vascular Repair in Metabolic Disease  
The present invention provides an isolated population of bone marrow-derived endothelial progenitor cells (EPCs) and uses thereof for the treatment of vascular diseases.
US20160229841 NOVEL BETA LACTAMS AS MODULATORS OF GLUTAMATE UPTAKE AND METHODS FOR USE THEREOF  
Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve...
9408856 Topical steroidal formulations  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
9402853 Topical steroidal formulations  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
US20160214303 Robotic Electroprosessing System and Method  
The present invention includes a robotic system for the enhanced automation, manipulation, and control of electroprocessing in two or three dimensions. In one embodiment, the system includes a...