Patents and Patent Applications from Temple University


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US20180200343 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION  
A method of treating a subject having or at risk for having a virus infection, by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated...
US20180193356 METHODS AND COMPOSITIONS FOR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS  
A method for the treatment of an individual suffering from non-alcoholic steatohepatitis is provided comprising administering to the individual in need of such treatment an effective amount of a...
US20180185307 Use of Short Chain Fatty Acids in Cancer Prevention  
The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the...
10005219 Robotic electroprosessing system and method  
The present invention includes a robotic system for the enhanced automation, manipulation, and control of electroprocessing in two or three dimensions. In one embodiment, the system includes a...
US20180169195 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION  
A method of treating a subject having or at risk for having a virus infection, by administering to the subject a therapeutically effective amount of a composition comprising a vector encoding a...
US20180169194 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION  
A method of treating a subject having a retroviral infection, by administering to the subject a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated...
US20180169193 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION  
Methods of inactivating a proviral DNA genome or a DNA genome integrated into the genome of a host cell latently infected with a retrovirus, by treating the host cell with a composition comprising...
9989539 Method for detecting injury to the brain  
Provided is a method for detecting injury to the brain comprising: a) determining the level of a tight junction (TJ) protein in exosomes isolated from a test sample from a subject, wherein the TJ...
9981020 Methods and compositions for RNA-guided treatment of HIV infection  
A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly...
US20180140682 GENE EDITING METHODS AND COMPOSITIONS FOR ELIMINATING RISK OF JC VIRUS ACTIVATION AND PML (PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY) DURING IMMUNOSUPPRESSIVE THERAPY  
A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least...
9975879 Beta lactams as modulators of glutamate uptake and methods for use thereof  
Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve...
US20180111893 POLYCATIONIC AMPHIPHILES AND POLYMERS THEREOF AS ANTIMICROBIAL AGENTS AND METHODS USING SAME  
The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes novel polymers of polycationic amphiphilic compounds...
US20180105867 METHODS OF SPECIFICALLY LABELING NUCLEIC ACIDS USING CRISPR/CAS  
Provided herein are methods of detecting a target nucleic acid sequence. In one embodiment, the method includes contacting genomic DNA with a guide RNA having a portion complementary to the target...
9933435 Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein  
Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a...
9925248 Methods and compositions for RNA-guided treatment of HIV infection  
A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly...
US20180073019 TAT-INDUCED CRISPR/ENDONUCLEASE-BASED GENE EDITING  
Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a core region and a TAR region of a HIV...
US20180073018 COMPOSITIONS AND METHODS FOR SPECIFIC REACTIVATION OF HIV LATENT RESERVOIR  
The present invention relates to compositions and methods for reactivation of HIV in vivo or in vitro. latently infected cell. In one embodiment, the present invention uses the CRISPR/Cas9 system...
9903871 Stabilized peptide fragments from nucleoredoxin X1 and uses thereof  
An embodiment of the invention relates to the use of stabilized cancer peptide fragments derived from “redoxin proteins” selected from the group consisting of thioredoxin; peroxiredoxin-1, 2 and...
9901639 Bone marrow origin progenitor cell or endothelial progenitor cell in combination with DNMT1 gene therapy for vascular repair in metabolic disease  
The present invention provides an isolated population of bone marrow-derived endothelial progenitor cells (EPCs) and uses thereof for the treatment of vascular diseases.
US20180049761 Infusion Catheter and Method of Use  
An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen...
US20180016262 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE  
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
US20180016261 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE  
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
US20180015152 Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway  
The present invention provides compositions and methods for treating or preventing a disease or disorder associated with endothelial activation, inflammation or atherogenesis, including but not...
US20180008641 Use of MicroRNA 375 in Augmenting Stem Cell Based and Endogenous Ischemic Tissue Repair  
The present invention relates to compositions and methods useful for treating ischemic injury. In one embodiment, the present invention uses an inhibitor of miR-375 in a cell to enhance its survival.
US20180008565 Use of Short Chain Fatty Acids in Cancer Prevention  
The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the...
US20180000970 RNA GUIDED ERADICATION OF HERPES SIMPLEX TYPE I AND OTHER RELATED HERPESVIRUSES  
The present invention relates to compositions and methods for the inhibition of the infectivity of a herpesvirus. In certain embodiments, the compositions and methods provide a CRISPR-associated...
9855225 Cannabinoid receptor treatments  
The present invention includes methods and compositions for treating a transplant recipient by administration of a CB2 receptor agonist either alone or in combination with one or more active...
US20170349628 Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications  
The present invention provides a novel cell penetrating peptide that transports proteins into cells and/or into nuclei and a pharmaceutical containing the peptide.
US20170347915 Magnetometer Surgical Device  
A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned...
9828458 Silica particles coated with β-cyclodextrin for the removal of emerging contaminants from wastewater  
Provided is a silica particle coated with β-cyclodextrin, wherein said cyclodextrin is attached to said silica particle via at least one crosslinking agent and/or at least one copolymer. Also...
US20170333572 RNA GUIDED ERADICATION OF HUMAN JC VIRUS AND OTHER POLYOMAVIRUSES  
The present invention includes methods and compositions for elimination of polyomaviruses, such as John Cunningham Virus (JVC), from host cells, and the treatment of polyomavirus related diseases,...
US20170332911 APPARATUS AND METHOD FOR SURFACE AND SUBSURFACE TACTILE SENSATION IMAGING  
A tactile sensor, computer readable medium, methods of using and manufacturing the tactile sensor, and methods and apparatuses for processing the information generated by the tactile sensor. The...
9814756 Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium  
A method for treatment of a subject having an inflammatory disease of the epithelium comprising the step of administering an amount of a composition comprising an isolated bacterial amyloid...
9802924 5-hydroxytryptamine receptor 7 activity modulators and their method of use  
Pharmaceiiticai compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
9795642 Enterococcus faecalis bacteriophage and uses thereof  
Bacteriophages are provided that infect strains of Enterococcus faecalis, an opportunistic bacterial pathogen that causes human disease. Also provided are methods of treating Enterococcus faecalis...
US20170298037 Novel 5-Hydroxytryptamine Receptor 7 Activity Modulators and Their Method of Use  
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of...
US20170290806 PCSK9 Inhibitors and Methods of Use Thereof  
The present invention relates to compositions and methods for treating lipid disorders in a subject. In one embodiment, the compositions of the present invention can be used to inhibit protease...
9763894 Inflammation therapy  
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
US20170253814 REMOVAL OF IRON CONTAMINANTS FROM HYDROCARBON OILS AND AQUEOUS BY-PRODUCTS OF OIL AND GAS RECOVERY/PRODUCTION  
Iron contaminants are removed from hydrocarbon oils, and from produced water or flowback water by-products of oil and gas production, by treatment of such liquids with a composition comprising a...
US20170246139 SYNERGISTIC COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS  
Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein...
9730961 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
9724304 Nanospheres for therapeutic agent delivery  
Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or...
US20170204151 Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for Treating Diseases and Disorders  
Isolated mesenchymal stem cells, which produce mRNA encoding TSG-6 protein or a biologically active fragment, derivative, or analogue thereof in an amount of at least a first preselected amount,...
US20170203009 Biomimetic Scaffold for Regenerative Dentistry  
The present invention relates to biomimetic scaffolds, methods for making the same, and methods for using the same. The scaffolds comprise a plurality of graded or tapered microchannels that...
9693999 Small molecule RNase inhibitors and methods of use  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
9688715 Synthetic pGpG analogs, methods of preparation and methods of use  
The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, and L are as defined herein. Methods for preparing compounds of Formula I are also...
9687816 Method of regeneration of beta-cyclodextrin based adsorbent-coated silica with ozone  
The present invention relates to systems and methods for regenerating β-cyclodextrin (β-CD) adsorbent after it has been used in a water decontamination process. The regeneration process of the...
US20170179524 Soft-Solid Crystalline Electrolyte Compositions And Methods For Producing The Same  
The present invention relates to compositions comprising ionic compounds surrounded by organic matrices, and methods for producing such compositions. In various embodiments, the compositions of...
US20170176408 Detection of HIV-1-Associated Neurocognitive Disorders  
Provided is a method of detecting mild neurocognitive disturbance (MNCD) or HIV associated dementia (HAD) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine...
US20170174734 DR6 Receptor Mediates the Leukemia Differentiation Activity of Angiocidin: A Potent Anti-Tumor Peptide  
The present invention provides compositions and methods of treating cancer by inducing the cellular differentiation activity of angiocidin.