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7635561 |
Methods of diagnosing, prognosing and treating breast cancer
The protein pRb2/p130 represses expression of the ER-α gene. Blocking pRb2/p130 expression or altering ER-α gene methylation to alter pRb2/p130 complex binding allows transcriptional activity of...
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US20090304736 |
NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA
The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame...
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US20090281066 |
Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones
Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X 1 , X 2 , R a , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , g, M, y, a, b, d, e, V, W, Z and Q...
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US20090275650 |
3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
Compounds of Formula I:
wherein R 1 , R 2 , M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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7612039 |
Method of cell growth inhibition with agnoprotein
The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the...
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7608578 |
Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7598232 |
Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X 1 , X 2 , R a , R 1 , R 2 ,R 3 , R 4 , R 5 , R 6 , R 7...
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7595347 |
Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone...
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7575858 |
Method of visualizing proteins bound to protein-binding membranes
A method of visualizing proteins bound to a protein-binding membrane is provided herein, comprising reacting proteins bound to protein-binding membranes with a compound of formula (I) wherein R a ,...
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US20090191193 |
Aryl Vinyl Sulfides, Sulfones, Sulfoxides and Sulfonamides, Derivatives Thereof and Therapeutic Uses Thereof
Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula I:
wherein Ar 1 , Ar 2 , D, G, m and n are as defined herein, salts,...
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US20090138979 |
MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONING
The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The...
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US20090124828 |
Unsaturated Sulfides, Sulfones, Sulfoxides and Sulfonamides Synthesis
α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I:
wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy...
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7482488 |
Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
Compounds useful as antiproliferative agents, radioprotective agents and cytoprotective agents, including, for example, anticancer agents, are provided according to formula I: wherein ring A, ring...
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US20090020129 |
Thoracic Stabilizer
A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and...
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US20080161252 |
Composition and Methods For the Treatment of Proliferative Diseases
Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I:
wherein R 1 is selected from the...
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US20080139635 |
Inflammation Therapy
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
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US20080070974 |
Alpha, Beta-Unsaturated Sulfones, Sulfoxides, Sulfonimides, Sulfinimides, Acylsulfonamides and Acylsulfinamides and Therapeutic Uses Thereof
α,β-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I:
wherein R 1 , R 2 , M 1 , M 2 , L, E 1 , E 2 , Q 1 , Q 2 and n are as...
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US20080063604 |
Method and composition for the site-selective gene delivery using viruses
Methods and compositions for the site-selective delivery of a gene to a site within the body of an animal where virus not encapsulated within the microbubbles is inactivated, for example by...
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US20080058290 |
Substituted Phenoxy-and Phenylthio-Derivatives for Treating Proliferative Disorders
Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
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7332161 |
Treatment of disease with antibodies against high molecular weight kininogen domain 5
Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to...
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7329641 |
Blood substitutes
The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric...
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7326326 |
System and methods for electrophoretic separation of proteins on protein binding membranes
Proteins can be rapidly separated to a high degree of resolution by electrophoresis on polymeric membranes that have high protein binding capacity. The electrophoretic separation is carried out in...
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7311521 |
Interproximal cavitation detection device and method
The present invention is direct to a device and method for diagnosis of enamel cavitation of an interproximal dental surface. And in particular, the invention is directed to a device and method for...
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US20070232649 |
Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof
Compounds of Formula I:
wherein R 1 , R 2 , M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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RE39681 |
1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula
wherein:
X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II:
wherein:
R 3 and R 4 are...
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7226904 |
Agents and methods for promoting bone growth
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively...
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7223550 |
Biosensor for defecting chemical agents
A biosensor for the identification of olfactants, including chemical and biological agents, prefumery, explosives and pharmaceuticals. The biosensors comprise robust eukaryotic cells, such as...
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US20070104756 |
Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7157719 |
Neutron source detection camera
A neutron imaging apparatus for obtaining an image of the general shape of a neutron emitting source and a bearing of the source relative to the apparatus, the apparatus comprising a chamber...
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US20060278224 |
Process for transient and steady state delivery of biological agents to the lung via breathable liquids
The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering...
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7122571 |
Substituted hydrazones as inhibitors of cyclooxygenase-2
Compounds useful as inhibitors of cyclooxygenase-2 activity have the formulae I or Ia:
wherein: Q 1 , Q 2 , n, m, X, Y and R are as defined herein.
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7101343 |
Implantable telemetric monitoring system, apparatus, and method
Systems, apparatus, and methods are disclosed for telemetrically monitoring parameters within a body of an animal such as a within a urinary bladder of a human. The system includes an implantable...
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US20060167317 |
Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
Compounds useful as antiproliferative agents, radioprotective agents and cytoprotective agents, including, for example, anticancer agents, are provided according to formula I: wherein ring A, ring...
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7056953 |
(E)-styryl sulfone anticancer agents
(E)-styryl benzylsulfones of formula I are useful as anticancer agents:
wherein R 1 , R 2 , R 3 , and R 4 are as defined herein.
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US20060115471 |
Treatment of disease with antibodies against high molecular weight kininogen domain 5
Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to...
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7053123 |
Substituted (e)-styryl benzylsulfones for treating proliferative disorders
(E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R 1 is selected from the group consisting of...
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7049603 |
Neutron source detection camera
A neutron imaging method for obtaining an image of the general shape of a neutron emitting source and a bearing of the source relative to an apparatus comprising a chamber comprising a gas with a...
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7038010 |
Agents and methods for promoting bone growth
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively...
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7033777 |
Method for detecting cockroach allergens and determining total allergen level
The present invention is directed to a method and a test kit for detecting cockroach allergens and/or determining the total allergen level. A sample from an environment in which cockroaches are...
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US20060052296 |
Method of cell growth inhibition with agnoprotein
The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the...
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US20050217997 |
Automated system for high-throughput electrophoretic separations
A cassette is disclosed for use in performing electrophoretic separations on a solid substrate. The cassette includes reservoirs for containing buffer, electrodes for receiving electrical current...
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6933128 |
Cell-based assay for screening cox-2 inhibitors
A cell-based assay is provided for screening substances for the capacity to inhibit COX-2 activity. The assay utilizes as a screening reagent a cell line which has been engineered to achieve...
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US20050130942 |
Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X 1 , X 2 , R a , R 1 , R 2 ,R 3 , R 4 , R 5 , R 6 , R 7...
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6905585 |
Automated system for high-throughput electrophoretic separations
A cassette is disclosed for use in performing electrophoretic separations on a solid substrate. The cassette includes reservoirs for containing buffer, electrodes for receiving electrical current...
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6878813 |
Human antithrombin IIIs and methods related thereto
The present invention discloses modified antithrombin III compounds and methods. The amino acid compounds of the present invention are useful in treating blood clotting disorders, as well as other...
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6869931 |
Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
Peptide analogs the high molecular weight kininogen domain 3 are potent inhibitors of angiogenesis. The peptides have the formula (a) X 1 -Asn-Asn-Ala-Thr-Phe-Tyr-Phe-Lys-X 2 , (b) X 3...
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6855735 |
Ketamine treatment of restless legs syndrome
The present invention is directed to a method for treating symptoms associated with Restless Legs Syndrome (RLS). The method includes administering to a warm-blooded animal in need of such...
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US20050032681 |
HUMAN ANTITHROMBIN IIIS AND METHODS RELATED THERETO
The present invention discloses modified antithrombin III compounds and methods. The amino acid compounds of the present invention are useful in treating blood clotting disorders, as well as other...
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6833480 |
(Z)-styrylbenzylsulfones and pharmaceutical uses thereof
Substituted (Z)-styrylbenzyl sulfones of the formulae (I, II, III, IV), pharmaceutically acceptable salts thereof, and compositions thereof are provided as cell antiproliferative agents, including,...
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6827822 |
Method and apparatus for increasing and modulating the yield shear stress of electrorheological fluids
A method for increasing and/or modulating the yield shear stress of an electrorheological fluid includes applying a sufficient electric field to the fluid to cause the formation of chains of...
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