Patents and Patent Applications from Temple University


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US20020028818 Alpha, beta-unsaturated sulfones for treating proliferative disorders  
Sulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: 1 wherein: Q1 is selected from the group consisting of (a) a phenyl radical according to...
US20020022666 Styryl sulfone anticancer agents  
Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the...
6347941 Partial dentin caries excavator  
A dental bur for use in repair of a carious lesion has a working surface including cutting elements which deflect or abrade upon encountering material having a hardness at or above a preselected...
6337091 Matrix for controlled delivery of highly soluble pharmaceutical agents  
The present invention provides a new simple polymeric matrix tablet that delivers highly soluble drugs over long periods of time and is easy to manufacture. More specifically, the drug is first...
6284726 Inhibition of angiogenesis by peptide analogs of high molecular weight kininogen domain 5  
Peptide analogs of the high molecular weight kininogen domain 5 are potent inhibitors of angiogenesis. The peptides have the formula X1 -(HGLGHGHEQQHGKGH)-X2 (I)wherein X1 is from zero to 25 amino...
6281201 Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof  
Antiviral compounds have the formula ##STR1##wherein m is zero, 1, 2 or 3; n is from 1 to 8, preferably 1, 2 or 3; most preferably 1 or 2; R is independently selected from the group consisting of...
6257889 Dental bur and method  
A dental bur for use in examining anomalies and in restoration of decayed areas of teeth with a bur head having a generally elongate conical shaped body with a base and an opposed vertex. Cutting...
6242472 Methods for the pulmonary delivery of biological agents  
Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an...
6232019 Gel electrolytes for electrochromic and electrochemical devices  
Gel electrolytes for electrochromic and electrochemical devices wherein in one embodiment polymeric gelling agents/atactic or syndiotactic, and isotactic PMMA, and a lithium salt in a suitable...
6214554 Chronic fatigue syndrome diagnosis  
Chronic fatigue syndrome is diagnosed through detection of an about 30 kDa RNase L molecule under native conditions in cellular extracts of RNase L-containing cells such as peripheral blood...
6207366 Chronic fatigue syndrome diagnosis  
Chronic fatigue syndrome is diagnosed through quantification of low and high molecular weight forms of RNase L in cellular extracts of RNase L-containing cells such as peripheral blood mononuclear...
6201154 Z-styryl sulfone anticancer agents  
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: ##STR1##wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group...
6166092 Fluorocarbon compositions for pulmonary therapy  
Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a...
6150400 Method for treating vulvar vestibulitis  
The present invention provides an improved method for treating vulvar vestibulitis in a patient, comprising applying to the vestibule or the vestibule and the vagina of a patient an effective...
RE36840 Multi-dimensional graphing in two-dimensional space  
A method and system for displaying a function in two dimensions where the function is made up of numerous independent variables and at least one dependent variable. A new independent variable...
6110500 Coated tablet with long term parabolic and zero-order release kinetics  
A tablet for the controlled release of an active pharmaceutical ingredient. The tablet comprises a core having a donut-like configuration with a cylindrical hole extending through the center of...
6106291 Selective dentin caries excavator  
A dental bur has a working surface including cutting elements which deflect or abrade upon encountering material at or above the preselected hardness corresponding to the lower limit of hardness...
6105572 Liquid ventilator  
A liquid ventilator having a dual loop, single pump configuration is disclosed. The liquid ventilator preferably utilizes two three-way valves for routing liquid from a reservoir in a regeneration...
6090580 Interferon responsive transcript (IRT-1)  
An isolated transcribed nucleotide sequence, termed interferon Responsive Transcript -1 (IRT-1), encodes a deduced 132 amino acid basically-charged protein. The invention is directed to IRT-1...
6090411 Monolithic tablet for controlled drug release  
A swellable hydrophillic matrix tablet that delivers drugs in a controlled manner over a long period of time and is easy to manufacture. More specifically, the drug is disposed in a matrix...
5989849 Antisense of oligonucleotides to c-kit proto-oncogene and in vitro methods  
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-kit gene. These "antisense" oligonucleotides are hybridizable...
5985565 Chronic fatigue syndrome diagnosis  
Chronic fatigue syndrome is diagnosed through detection of an about 30 kDa RNase L molecule under native conditions in cellular extracts of RNase L-containing cells such as peripheral blood...
5945125 Controlled release tablet  
A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60% of a water swellable polymer and a lubricant. The water swellable polymer...
5878749 Non-invasive methods and apparatus for in vivo measurement of intra-variceal pressure and wall tension  
A method for evaluating a varix, including the steps of: (a) placing a system for observing whether the varix is open or closed into a region adjacent to the varix; (b) placing a system for...
5863905 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof  
Optically active antiviral compounds having the formula ##STR1## wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1,...
5808233 Amorphous-crystalline thermocouple and methods of its manufacture  
A thermocouple formed of a length of a single composition having first solid phase section adjoining a second solid phase section, and a transition therebetween. One method of making such...
5801247 Process for the enantioselective synthesis of hydroxypyrrolidines from amino acids and products thereof  
The present invention relates to processes for the enantioselective synthesis of hydroxypyrrolidines from amino acids. An amino methyl ester is used as the starting material. The ester is reacted...
5789261 Solid phase immunoassay  
Solid supports for solid phase immunoassays comprise polyethyleneimine-coated negatively charged polymeric materials. The combination of negatively-charged polymer support and polyethyleneimine...
5783212 Controlled release drug delivery system  
The present invention pertains to a controlled release pharmaceutical tablet having at least three layers, two barrier layers and one drug layer. The two barrier layers erode more quickly than the...
5770693 Calpain-inhibiting peptide analogs of the kininogen heavy chain  
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by...
5741248 Fluorochemical liquid augmented cryosurgery  
A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic...
5707352 Pulmonary delivery of therapeutic agent  
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
5700785 3'-deoxy or 3'-O-substituted-2',5'-oligoadenylates as antiviral agents  
Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective therapeutic agents, particularly against HIV infection....
5686113 Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses  
An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic...
5665370 Compositions containing cockroach aggregation pheromones, their production and uses  
An insecticidal product comprises a solid substrate impregnated with sterile cockroach aggregation pheromones, a sterile insecticidal composition comprises a solvent extract of the product, which...
5663294 Calpain-inhibiting peptide analogs of the kininogen heavy chain  
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by...
5652222 Selective inhibition of leukemic cell proliferation by bcr-abl antisense oligonucleotides  
Leukemias characterized by the presence of the Philadelphia chromosome and the expression of the hybrid bcr-abl gene are treated with antisense oligonucleotides complementary to a target sequence...
5643889 Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof  
A cholesterol-cordycepin conjugate having the formula ##STR1## wherein: n is an integer from 1 to 8; R1 is selected from the group of consisting of T, T' and Y; T is ##STR2## T' is ##STR3## where...
5643758 Production and purification of a protein fused to a binding protein  
Methods and products are provided for producing and/or purifying virtually any hybrid polypeptide molecule employing recombinant DNA techniques. More specifically, a DNA fragment coding for a...
5641747 Treatment of osteopetrotic diseases  
Bone resorption by osteoclast cells is promoted by activated vitamin D-binding factor, thereby providing an effective treatment for osteopetrosis. Conversely, inflammation-mediated bone loss is...
5635385 Multi-unit ribozyme inhibition of oncogene gene expression  
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles...
5590651 Breathable liquid elimination analysis  
The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory...
5582580 Direct manual cardiac compression device  
A heart massager for substernal heart massage is disclosed. The heart massager has a heart-contacting member having a surface which is at least partially concave for contacting the heart,...
5571074 Inflatable and expandable direct manual cardiac compression device  
A heart massager for substernal heart massage is disclosed. The heart massager utilizes a heart-contacting member adapted for insertion into a thoracic cavity for directly contacting the heart and...
5562608 Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation  
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
5556840 2',5'-phosphorothioate oligoadenylates as anitiviral agents  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internecleotide...
5550111 Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof  
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate...
5532340 Tumor suppressor protein PRB2, related gene products, and DNA encoding therefor  
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
5517656 Multicomputer system and method  
A multicomputer system and method for automatic sequential-to-parallel program partition, scheduling and execution. The plurality of computer are connected via a uni-directional slotted ring...
5490986 Encapsulated perfluorocarbons  
An artificial blood substitute comprising Lewis acid--Lewis base salt film microcapsule having a perfluorocarbons encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine,...