Patents and Patent Applications from Temple University


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6090580 Interferon responsive transcript (IRT-1)  
An isolated transcribed nucleotide sequence, termed interferon Responsive Transcript -1 (IRT-1), encodes a deduced 132 amino acid basically-charged protein. The invention is directed to IRT-1...
6090411 Monolithic tablet for controlled drug release  
A swellable hydrophillic matrix tablet that delivers drugs in a controlled manner over a long period of time and is easy to manufacture. More specifically, the drug is disposed in a matrix...
5989849 Antisense of oligonucleotides to c-kit proto-oncogene and in vitro methods  
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-kit gene. These "antisense" oligonucleotides are hybridizable...
5985565 Chronic fatigue syndrome diagnosis  
Chronic fatigue syndrome is diagnosed through detection of an about 30 kDa RNase L molecule under native conditions in cellular extracts of RNase L-containing cells such as peripheral blood...
5945125 Controlled release tablet  
A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60% of a water swellable polymer and a lubricant. The water swellable polymer...
5878749 Non-invasive methods and apparatus for in vivo measurement of intra-variceal pressure and wall tension  
A method for evaluating a varix, including the steps of: (a) placing a system for observing whether the varix is open or closed into a region adjacent to the varix; (b) placing a system for...
5863905 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof  
Optically active antiviral compounds having the formula ##STR1## wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1,...
5808233 Amorphous-crystalline thermocouple and methods of its manufacture  
A thermocouple formed of a length of a single composition having first solid phase section adjoining a second solid phase section, and a transition therebetween. One method of making such...
5801247 Process for the enantioselective synthesis of hydroxypyrrolidines from amino acids and products thereof  
The present invention relates to processes for the enantioselective synthesis of hydroxypyrrolidines from amino acids. An amino methyl ester is used as the starting material. The ester is reacted...
5789261 Solid phase immunoassay  
Solid supports for solid phase immunoassays comprise polyethyleneimine-coated negatively charged polymeric materials. The combination of negatively-charged polymer support and polyethyleneimine...
5783212 Controlled release drug delivery system  
The present invention pertains to a controlled release pharmaceutical tablet having at least three layers, two barrier layers and one drug layer. The two barrier layers erode more quickly than the...
5770693 Calpain-inhibiting peptide analogs of the kininogen heavy chain  
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by...
5741248 Fluorochemical liquid augmented cryosurgery  
A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic...
5707352 Pulmonary delivery of therapeutic agent  
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
5700785 3'-deoxy or 3'-O-substituted-2',5'-oligoadenylates as antiviral agents  
Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective therapeutic agents, particularly against HIV infection....
5686113 Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses  
An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic...
5665370 Compositions containing cockroach aggregation pheromones, their production and uses  
An insecticidal product comprises a solid substrate impregnated with sterile cockroach aggregation pheromones, a sterile insecticidal composition comprises a solvent extract of the product, which...
5663294 Calpain-inhibiting peptide analogs of the kininogen heavy chain  
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by...
5652222 Selective inhibition of leukemic cell proliferation by bcr-abl antisense oligonucleotides  
Leukemias characterized by the presence of the Philadelphia chromosome and the expression of the hybrid bcr-abl gene are treated with antisense oligonucleotides complementary to a target sequence...
5643889 Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof  
A cholesterol-cordycepin conjugate having the formula ##STR1## wherein: n is an integer from 1 to 8; R1 is selected from the group of consisting of T, T' and Y; T is ##STR2## T' is ##STR3## where...
5643758 Production and purification of a protein fused to a binding protein  
Methods and products are provided for producing and/or purifying virtually any hybrid polypeptide molecule employing recombinant DNA techniques. More specifically, a DNA fragment coding for a...
5641747 Treatment of osteopetrotic diseases  
Bone resorption by osteoclast cells is promoted by activated vitamin D-binding factor, thereby providing an effective treatment for osteopetrosis. Conversely, inflammation-mediated bone loss is...
5635385 Multi-unit ribozyme inhibition of oncogene gene expression  
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles...
5590651 Breathable liquid elimination analysis  
The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory...
5582580 Direct manual cardiac compression device  
A heart massager for substernal heart massage is disclosed. The heart massager has a heart-contacting member having a surface which is at least partially concave for contacting the heart,...
5571074 Inflatable and expandable direct manual cardiac compression device  
A heart massager for substernal heart massage is disclosed. The heart massager utilizes a heart-contacting member adapted for insertion into a thoracic cavity for directly contacting the heart and...
5562608 Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation  
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
5556840 2',5'-phosphorothioate oligoadenylates as anitiviral agents  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internecleotide...
5550111 Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof  
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate...
5532340 Tumor suppressor protein PRB2, related gene products, and DNA encoding therefor  
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
5517656 Multicomputer system and method  
A multicomputer system and method for automatic sequential-to-parallel program partition, scheduling and execution. The plurality of computer are connected via a uni-directional slotted ring...
5490986 Encapsulated perfluorocarbons  
An artificial blood substitute comprising Lewis acid--Lewis base salt film microcapsule having a perfluorocarbons encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine,...
5472945 Modulation of blood pressure and inhibition of platelet activation with kininogen fragment  
The release of bradykinin into the circulatory system is potentiated by administration of a polypeptide having an amino acid sequence corresponding to domain 3 of the human kininogen heavy chain....
5457049 Tumor suppressor protein pRb2, related gene products, and DNA encoding therefor  
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
5444156 Monoclonal antibodies to human plasma prekallikrein  
Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein,...
5444052 Amphotericin B composition with enhanced fungal activity  
Fungal infections are treated by administering a combination of (a) amphotericin B, and (b) a glycerol ether selected from the group consisting of (i) HOCH2 CHOHCH2 OR, (ii) HOCH2 CH(OR1)CH2 OH,...
5437864 Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor  
This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody...
5429123 Process control and apparatus for ventilation procedures with helium and oxygen mixtures  
A process is provided for controlling a ventilation procedure wherein a heliox ventilation system passes a breathing medium through at least a portion of a patient's pulmonary pathways. In this...
5427916 Method for predicting the effectiveness of antineoplastic therapy in individual patients  
The effectiveness of selected antineoplastic agents may be determined in individual patients by comparing the level of expression of one or more selected growth-regulated genes in neoplastic cells...
5412979 Method and apparatus for dissolution testing of a dosage form  
An apparatus and method determines the dissolution of a drug from a dosage form, most particularly a swellable dosage form. An inert, transparent cylindrical vessel having a hemispherical bottom...
5405939 2',5'-phosphorothioate oligoadenylates and their covalent conjugates with polylysine  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide...
5401506 Stabilized insect nematode compositions  
An insecticidal composition comprising a first composition having an effective amount of at least one species of entomopathogen distributed in a matrix. A second composition selected from...
5381534 System for automatically generating efficient application - customized client/server operating environment for heterogeneous network computers and operating systems  
A high level virtual computer in a heterogeneous hardware and software environment. A user specifies the hardware and software configuration of a virtual computer employing multiple coarse grain...
5380646 Thrombus detection using radiolabelled disintegrins  
Radiolabelled polypeptides derived from the Viperidae disintegrins are provided as well as a method for the detection of venous and arterial thrombi, pulmonary emboli and tumors or abscesses that...
5350359 Control, treatment and/or diagnosis of physiological conditions with degassed perfluorocarbon liquid  
This invention pertains to the use of a degassed perfluorocarbon ("PFC") liquid as a method of removing gas emboli from parts of a patient's internal anatomy. Moreover, the invention can be used...
5347028 Highly functionalized polycyclosiloxanes and their polymerization into thermally reversible living rubbers  
A composition curable to a thermally reversible rubber comprises (i) a strong acid catalyst having a pKa of less than about -9, (ii) at least one polycyclosiloxane containing at least one...
5336667 Method for inhibiting the ahesion of platelet with alboaggregins: platelet agonists which bind to platelet membrane glycoprotein IB  
A family of proteins are provided which may be purified from snake venom. Each protein binds to the 45 kDa N-terminal domain of human platelet glycoprotein Ib, thereby inhibiting the binding of...
5335650 Process control for liquid ventilation and related procedures  
A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes a breathing liquid through at least a portion of a patient's pulmonary pathways. In this...
5330836 Functionalized silica particle and use thereof for cross-linking silicones  
Particulate fillers containing Si-OH groups are functionalized by treatment with a silica bonding agent. The treated particles are effectively polyfunctional, and may be used to prepare highly...
5298589 Highly functionalized polycyclosiloxanes and their polymerization into thermally reversible living rubbers  
A composition curable to a thermally reversible rubber comprises (i) a strong acid catalyst having a pKa of less than about -9, (ii) at least one polycyclosiloxane containing at least one...