Patents and Patent Applications from Temple University


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US20130303585 SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20130296386 SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20130273340 Self-assembly of small structures  
Small structures are formed by applying to a substrate a structural material and a layer of a sacrificial material having a lower surface energy than the structural material, to form an...
8557842 Cocaine analogs and methods of preparation and uses thereof  
The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8...
8540715 Locking rod fusion device  
A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a...
US20130237685 LINEAR ASSEMBLIES, BRANCHED ASSEMBLIES, MACROCYCLES AND COVALENT BUNDLES OF FUNCTIONALIZED BIS-PEPTIDES  
Provided is a macromolecule comprising two or more functionalized bis-peptides connected by one or more linkers, and methods of making thereof. In some embodiments, the functionalized bis-peptides...
US20130202752 CHOCOLATE PRODUCTION METHOD AND APPARATUS  
The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery...
US20130196963 TOPICAL STEROIDAL FORMULATIONS  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
US20130196959 TOPICAL STEROIDAL FORMULATIONS  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
8492564 Salvinorin derivatives and uses thereof  
The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood...
8492515 Antibacterial peptides active in systemic infections  
Antimicrobial peptides of the formula are provided: X1—X2—PrO—X3—X4—PrO-Arg-Pro-Tyr-Leu-Pro-X5-Pro-Arg-Pro-Pro-A rg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino...
US20130183317 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 AS A CANCER BIOMARKER  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8470772 Leptin agonist and methods of use  
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related...
8454937 Method and composition for the site-selective delivery using viruses encapsulated in microbubbles  
Methods and compositions for the site-selective delivery of a gene to a site within the body of an animal where virus not encapsulated within the microbubbles is inactivated, for example by...
US20130131058 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF  
Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing...
8441720 Methods and devices for generation of broadband pulsed radiation  
Methods and apparatus for non-collinear optical parametric ampliffication (NOPA) are provided. Broadband phase matching is achieved with a non-collinear geometry and a divergent signal seed to...
8431555 Topical steroidal formulations  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
US20130096335 PROCESS FOR SYNTHESIS OF SILANE DIPEPTIDE ANALOGS  
The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the...
8420333 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
US20130085076 BORRELIA BURGDORFERI BACTERIAL ANTIGEN DIAGNOSIC TEST USING POLYMERIC BAIT CONTAINING CAPTURE PARTICLES  
The invention relates to both a sensitive method for the capture and detection of low-abundance Borrelia burgdorferi (Bb) bacterial antigens allowing for the diagnosis of Lyme Disease using...
8408202 Open-circuit liquid ventilator  
An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable...
US20130070074 APPARATUS AND METHOD FOR SURFACE AND SUBSURFACE TACTILE SENSATION IMAGING  
A tactile sensor, computer readable medium, methods of using and manufacturing the tactile sensor, and methods and apparatuses for processing the information generated by the tactile sensor. The...
8375943 Process for transient and steady state delivery of biological agents to the lung via breathable liquids  
The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering...
US20130037423 Multi-Point Cellular Analysis  
Provided are devices and methods for performing multi-point analysis on biological materials, such as cells. In one embodiment, the devices simultaneously collect information related to a...
US20120329828 Cocaine Analogs and Methods of Preparation and Uses Thereof  
The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8...
8333972 Unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions  
The invention provides a novel antigen, MPD6, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′...
8333880 Method for detecting disease markers  
Disease specific markers, in particular cancer markers, can be detected by electrophoretically separating proteins and protein complexes from a biological sample on a protein binding polymeric...
US20120305773 METHODS AND SYSTEMS FOR REMOTELY DETECTING HAZARDOUS MATERIALS USING ELECTROMAGNETIC ENERGY  
Systems and methods for remotely detecting nuclear and non-nuclear materials such as chemical agents and gas-phase explosives are disclosed. Nuclear and non-nuclear materials may be detected by...
8324190 Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones  
Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
US20120269831 SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF  
Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions,...
US20120258539 USE OF NIBP POLYPEPTIDES  
Methods for regulating NF-κB activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide,...
8273538 Blood monocyte CD163 expression as a biomarker in HIV-1 infection and neuroaids  
The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises...
US20120228205 METHOD AND APPARATUS FOR TREATMENT OF A FLUID  
An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the...
US20120219570 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 AS A CANCER BIOMARKER  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
US20120183555 SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCER  
Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided....
US20120149009 VAPORIZATION DEVICE AND METHOD FOR IMAGING MASS SPECTROMETRY  
Methods and apparatus for analyzing samples are disclosed. The samples are analyzed by vaporizing molecules from a sample in a sample area with a femtosecond laser beam under ambient conditions,...
US20120142585 LEPTIN ANTAGONIST AND METHODS OF USE  
This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used...
8183048 Assay for screening/ranking antioxidants based on their effects on membrane sterol lateral organization  
A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of...
US20120122987 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35)  
Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke...
8173023 Method and apparatus for treatment of a fluid  
An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the...
US20120108504 LEPTIN AGONIST AND METHODS OF USE  
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance,...
8156954 Method for reduction of crude oil viscosity  
The present invention relates to a method for reducing the viscosity and facilitating the flow of petroleum-based fluids. The method includes the step of applying an electric field of sufficient...
8143453 Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis  
α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides,...
8143428 Heteroaryl sulfones and sulfonamides and therapeutic uses thereof  
Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
8143213 Effect of TULA on HIV  
A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a fragment of TULA containing a UBA domain, a...
US20120024044 SYSTEMS AND METHODS FOR DETECTING CONCEALED NUCLEAR MATERIAL  
Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of...
8106033 Composition and methods for the treatment of proliferative diseases  
Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group...
US20120021130 METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL  
This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of...
US20120017467 ORTHOTIC SHOE AND INSOLE ASSEMBLIES  
An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via...
US20120010219 SALVINORIN DERIVATIVES AND USES THEREOF  
The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood...