Patents and Patent Applications from Temple University


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US20150175649 SYNTHETIC pGpG ANALOGS, METHODS OF PREPARATION AND METHODS OF USE  
The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, and L are as defined herein. Methods for preparing compounds of Formula I are also...
9062103 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
9044036 Chocolate production method and apparatus  
The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery...
US20150147766 METHOD FOR DETERMINING DISEASE SEVERITY IN TAUOPATHY-RELATED NEURODEGENERATIVE DISORDERS  
A method for determining disease severity in a subject afflicted with a tauopathy-related neurodegenerative disease comprises detecting the level of a PINCH protein or isoform thereof in a test...
9040583 Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)  
Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke...
US20150140441 SOLID POLYMER ELECTROLYTE COMPOSITION FOR LITHIUM ION BATTERY  
A composition suitable as a solid polymer electrolyte for a lithium ion battery comprises a mixture of polyoctahedral silsesquioxane-phenyl7(BF3Li)3 and a poly(ethylene oxide).
US20150140127 METHOD FOR DETECTING INJURY TO THE BRAIN  
Provided is a method for detecting injury to the brain comprising: a) determining the level of a tight junction (TJ) protein in exosomes isolated from a test sample from a subject, wherein the TJ...
US20150119326 ADMINISTRATION OF ANGIOCIDIN FOR THE TREATMENT OF CANCER  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth...
9001325 Filament-based stimulated Raman detection  
In apparatus and methods of Raman spectroscopy in air, a target region is excited by a laser pump pulse exceeding the critical power for self-focusing in air and having a duration after...
8987493 Process for synthesis of silane dipeptide analogs  
The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the...
8987267 2-substituted-8-alkyl-7-OXO-7,8-dihydropyrido[2,3-D]pyrimidine-6-carbonitriles and uses thereof in treating proliferative disorders  
Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing...
8980843 Leptin agonist and methods of use  
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance,...
8980269 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8979895 Method and apparatus of endoscopic suturing  
An adjustable suture assembly is provided that may be employed in various surgical procedures to draw and/or hold tissue and/or muscle together. The suture assembly may include a suture lock or...
US20150065499 3-AMINOTHIENO[3,2-c]QUINOLINE DERIVATIVES, METHODS OF PREPARATION AND USES  
The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, and Y are as defined herein. Methods for preparing compounds of Formula...
US20150053620 WATER TREATMENT  
The present invention features compositions and methods for reducing the concentration of an endocrine disrupting agent in an aqueous solution. We describe compositions comprising various...
US20150010901 METHOD FOR DETECTING POLYOMAVIRUS REACTIVATION  
The invention provides methods of detection and monitoring of polyomavirus reactivation and active polyomavirus infections using a biological fluid sample. Also provided are methods of risk...
US20140365139 SYSTEM AND METHOD FOR ASSESSING A CONDITION OF A PATIENT WITH A CHRONIC ILLNESS  
Provided are a method and system for assessing a condition of a patient with a chronic condition. The system includes a storage device that stores a plurality of variables relating to symptoms...
8901083 Administration of angiocidin for the treatment of leukemia  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth...
8895739 Acylation of hindered amines and functionalized bis-peptides obtained thereby  
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable...
8889696 Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof  
Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions,...
US20140294843 DIAGNOSIS AND TREATMENT OF COPD  
Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a...
US20140279316 APPARATUS, METHOD, AND COMPUTER READABLE MEDIUM FOR DISPLAYING GENERAL LEDGER FUNDS IN A CHECKBOOK FORMAT  
Apparatus, computer readable medium, and a method for interacting with a user on a computer for displaying grants, the method comprising displaying grants with an icon indicating a balance of the...
8826997 Automatic reversible temperature responsive valve and fire sprinkler  
A fire sprinkler including a generally tubular body having inlet and outlet ends is disclosed. The body defines a fluid flow passage extending between the inlet and the outlet such that the outlet...
US20140234827 SSAT mRNA TRANSLATION REPRESSION AND ACTIVATION  
The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has...
US20140231352 SILICA PARTICLES COATED WITH BETA-CYCLODEXTRIN FOR THE REMOVAL OF EMERGING CONTAMINANTS FROM WASTEWATER  
Provided is a silica particle coated with β-cyclodextrin, wherein said cyclodextrin is attached to said silica particle via at least one crosslinking agent and/or at least one copolymer. Also...
8808702 Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof  
Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of...
US20140216116 SIEVED COMPOST AND HYDROGEL-BASED METHOD AND COMPOSITION FOR SEED PRIMING  
Provided is a method for seed priming comprising the steps of treating seed with a seed priming composition comprising sieved compost, hydrogel and water in a ratio of sieved...
8785395 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases  
The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that...
8778890 Leptin antagonist and methods of use  
This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used...
US20140186431 COMBINED MESENCHYMAL STEM CELL TRANSPLANTATION AND TARGETED DELIVERY OF VEGF FOR TREATMENT OF MYOCARDIAL INFARCTION  
Compositions and kits useful for the treatment of myocardial infarction comprise (i) P-selectin-targeted carriers (e.g., P-selectin-targeted liposomes, quantum dots or biodegradable nanoparticles)...
US20140086941 SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF  
The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also...
8664272 Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia  
Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1...
US20140057833 ADIPONECTIN RECEPTOR AGONISTS AND METHODS OF USE  
Short peptide mimetics of adiponectin suitable for development as pharmaceutical agonists in the treatment of cellular proliferative disorders such as cancer and atherosclerosis are provided.
US20140030735 BIOMARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE  
The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive...
US20140011206 DETERMINATION OF OOCYTE QUALITY  
A method for evaluating the quality of mammalian oocytes comprises determining the expression level of one or more of the genes ACPP, AQP11, CCDC126, CLU, CYP11 A1, CYP19A1, EGR3, FN1, FOSL2,...
US20130337077 NANOSPHERES FOR THERAPEUTIC AGENT DELIVERY  
Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or...
US20130321801 FILAMENT-BASED STIMULATED RAMAN DETECTION  
In apparatus and methods of Raman spectroscopy in air, a target region is excited by a laser pump pulse exceeding the critical power for self-focusing in air and having a duration after...
8598521 Vaporization device and method for imaging mass spectrometry  
Methods and apparatus for analyzing samples are disclosed. The samples are analyzed by vaporizing molecules from a sample in a sample area with a femtosecond laser beam under ambient conditions,...
8597605 Purification of single walled carbon nanotubes by dynamic annealing  
A method for removing impurities from carbon nanotubes is described. Impurities may be removed from the carbon nanotubes by exposing the carbon nanotubes to a temperature, and controlling the...
US20130310421 TREATMENT OF AMYLOID BETA AMYLOIDOSIS  
Provided is a method for the treatment and/or prevention of an amyloid beta amyloidosis in a subject comprising the step of administering to the subject an effective amount of a...
US20130303585 SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20130296386 SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20130273340 Self-assembly of small structures  
Small structures are formed by applying to a substrate a structural material and a layer of a sacrificial material having a lower surface energy than the structural material, to form an...
8557842 Cocaine analogs and methods of preparation and uses thereof  
The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8...
8540715 Locking rod fusion device  
A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a...
US20130237685 LINEAR ASSEMBLIES, BRANCHED ASSEMBLIES, MACROCYCLES AND COVALENT BUNDLES OF FUNCTIONALIZED BIS-PEPTIDES  
Provided is a macromolecule comprising two or more functionalized bis-peptides connected by one or more linkers, and methods of making thereof. In some embodiments, the functionalized bis-peptides...
US20130202752 CHOCOLATE PRODUCTION METHOD AND APPARATUS  
The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery...
US20130196963 TOPICAL STEROIDAL FORMULATIONS  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...
US20130196959 TOPICAL STEROIDAL FORMULATIONS  
The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula...