Patents and Patent Applications from Temple University


Match Document Document Title
5288490 Thrombus-targeted complexes of plasminogen activator and fibrin fragments  
Thrombolytic hybrids are formed as covalent or non-covalent complexes of fibrin fragments and plasminogen activator molecules. Native plasmin degradation fragments of fibrin or non-native fibrin...
5285794 Respiratory gas monitor  
A method and apparatus for monitoring the respiratory gas of a patient includes an adjustable volume gas mixing chamber which allows for the differences in lung capacity of patients from neonate...
5284663 Salt film encapsulated perfluorocarbons  
An artificial blood substitute comprising Lewis acid--Lewis base salt film microcapsule having a perfluorocarbon encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine...
5254654 Monodispersed polydimethylsiloxane-α,ω-diol fluids and α,ω-substituted polydimethylsiloxanes and polydimethylcyclosiloxanes prepared therefrom  
The molecular weight distribution of polydimethylsiloxane-α, ω-diol fluids is reduced by contacting the fluid with an alkaline earth metal hydride or hydroxide. Molecular weight distributions...
5247116 Acid-catalyzed process for the production of cyclosiloxanes  
Cyclosiloxanes are produced by the acid-catalyzed redistribution of siloxane bonds in polysiloxane fluids at a temperature of about 20-200° C. Little catalyst and no water or solvent is required....
5242795 TCL-5 gene rearrangement involved in T-cell leukemia and melanoma  
A gene is described which is involved in the neoplastic process of a number of different cancers. The gene, termed TCL-5, is located at chromosome 1, band 32, adjacent to the chromosome junction...
5238681 Insect bait station  
An insect bait station comprising a first compartment with a hydrated macel containing at least one species of entomopathogen and a second compartment containing a hydrated water retentive...
5229335 Ceramic materials and their synthesis by a xerogel process  
The invention provides a process for producing high phase purity ceramic materials through the utilization of organic gelling agents. The process comprises the following steps: (a) dissolving...
5228119 Multi-dimensional graphing in two-dimensional space  
A method and system for displaying a function in two dimensions where the function is made up of numerous independent variables and at least one dependent variable. A new independent variable...
5198338 Molecular probing for human T-cell leukemia and lymphoma  
A very specific area of chromosome 10, band q11 is taught to be the site of chromosome breakpoints which occur in the course of translocations. The translocation brings sequences of the T-cell...
5188897 Encapsulated 2',5'-phosphorothioate oligoadenylates  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide...
5185323 Suppression of megakaryocytopoiesis employing platelet factor 4 antimaturation factor  
Antimaturation factor (platelet factor 4 or active peptide segments thereof) is employed in the clinical treatment of coagulation disorders as an anticoagulant operating via an autoregulator...
5158536 Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids  
A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating...
5158364 Method of making and using an improved liquid crystal cumulative dosimeter container  
A method of making and using a liquid crystal cumulative dosimeter container including a resilient outer body sealed to confine a first liquid crystal composition constituent and a second liquid...
5149965 Precision radiography scaling device  
At least one radiopaque sphere of known dimensions with means for positioning same in a radiographic image field and a method for scaling radiographic images including straight AP and lateral...
5149628 Methods for detecting bcl-3 gene in human leukemias  
Bcl-3 gene sequences can be used to monitor the success of chemotherapy and to detect minimal residual disease in patients having hematopoietic malignancies. Bcl-3 sequences can also be used to...
5143709 Process for production of graphite flakes and films via low temperature pyrolysis  
Electrically conductive carbon flakes and films are prepared in high yield by the pyrolysis of cyclic aromatic hydrocarbons, optionally halogenated, in the presence of a dehydrogenating agent at...
5141744 Insecticide delivery system and attractant  
An insecticidal composition in the form of a hydrated macrogel containing at least one species of entomopathogen and a hydrated water retentive compound which acts as a water-reservoir for the...
5132117 Aqueous core microcapsules and method for their preparation  
A microcapsule comprising an aqueous core, and capsular membrane formed from the interfacial reaction product of a hydrophilic polymeric Lewis acid or salt thereof with a lipophilic Lewis base or...
5126439 Artificial DNA base pair analogues  
The present invention is directed to new artificial base pairs comprising complementary artificial purines and pyrimidines and methods of using artificial complementary base pairs.
5122115 Multilumen angiography catheter  
A multiple lumen catheter specifically adapted for selective visualization of one or the other of the coronary arteries. One lumen of the multiple lumen catheter is adapted to deliver contrast...
5112804 Pharmaceutical composition and method of intranasal administration  
A composition and method for nasal administration of pharmaceuticals utilizes glycyrrhetinic acid as an absorption enhancer. The composition comprises an effective amount of the pharmaceutically...
5110215 Container for liquid crystal cumulative dosimeter  
A container for a liquid crystal cumulative dosimeter including a resilient outer body sealed to confine a first liquid crystal composition constituent and a second liquid crystal composition...
5108420 Aperture occlusion device  
A device consisting of a wire for occluding an aperture within a body surface, such as atrial and ventricular septal defects (and the method of using such a device). The wire comprises two...
5104704 Gel-interleaved tamper-evident wrap  
A tamper evident over-wrap is disclosed which employs a multi-layered system including three overlapping layers of containment material and two interleaved layers of reactive material, at least...
5098890 Antisence oligonucleotides to c-myb proto-oncogene and uses thereof  
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-myb gene. These "antisense" oligonucleotides are hybridizable...
5093198 Adjuvant-enhanced sustained release composition and method for making  
Improved sustained-release delivery forms comprising Lewis acid-Lewis base salt microparticulate material modified by the addition of at least one additional constituent known as an "adjuvant"...
5066592 Trigramin - a platelet aggregation inhibiting polypeptide  
Trigramin, a 72-amino acid polypeptide, has the following amino acid sequence: EAGEDCDCGSPANPCCDAATCKLIPGAQCGEGLCCDQCSFIEEGTVCRIARGDDLDDYCN GRSAGCPRNPFH. The molecule is a potent inhibitor of...
5047323 Method for detecting human kininogen using monoclonal antibodies thereto  
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight...
4990498 2- and 8-azido(2'-5')oligoadenylates and antiviral uses thereof  
Compounds of the formula ##STR1## REFERENCE TO GOVERNMENT GRANT The invention described herein was made, in part, in the course of work supported by National Institutes of Health Grants GM 27210...
4978662 2-substituted trimethylpyrazine derivatives as inhibitors of platelet function  
Novel 2-substituted trimethylpyrazine derivatives of the formula: ##STR1## wherein R is alkylamino, 4-methyl-1-piperazinyl, piperidino, morpholino or 2-trimethylpyrazinepropenyl.These novel...
4975463 Ethyl(or methyl) 4-acetoxy(or propionyloxy)-5,6,7 or 8-di(or tri-)substituted-2-naphthoates  
Novel antiviral ring-substituted ethyl or methyl 4-acetoxy (or propionyloxy)-2-naphthoates are provided.
4966817 Transition-metal-carbon composites and methods for making  
Carbon-transition metal composite formed via pyrolytic decomposition of a polycyanogen in the presence of a transition metal or a salt thereof.
4963657 Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same  
Novel cell lines produce monoclonal antibody to the light chain region of human factor XII. Three such cell lines, ATCC #HB-9703 through ATCC #HB-9704, are formed by fusing SP2/0-Ag14 myeloma...
4925841 Mannich bases of spirosuccinimides  
Mannich bases of spirosuccinimides are provided having anticonvulsant, sedative and antileukemic activity. The compounds have the following formula wherein ring A is a saturated or unsaturated...
4924624 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof  
Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide...
4922897 Apparatus and method for reconstructive surgery  
A method and apparatus for the permanent surgical reconstruction of the anterior cruciate ligament in the human knee, which will stabilize the tibia and femur relative to each other and restore a...
4917892 Encapsulated topical delivery system  
Delivery system for topical application comprising a highly viscous carrier containing dissolved or dispersed and microencapsulated topically-active agents providing immediate and sustained...
4908431 Monoclonal antibodies to human kininogen and methods of preparing same  
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight...
4882272 High molecular weight kininogen assay  
An assay for functional high molecular weight kininogen in plasma is provided. A plasma sample of unknown functional high molecular kininogen content is treated to inactivate plasma protease...
4867963 Enhancement of NMR imaging of tissue by paramagnetic pyrophosphate contrast agent  
Nuclear magnetic resonance imaging of animal or human tissue is enhanced when a paramagnetic pyrophosphate compound is administered intraveneously as a contrast agent. The contrast agent is...
4866998 Medical examination table with probe holder  
A method of predicting the occurrence of deep vein thrombosis after a surgical procedure comprises monitoring changes in the internal diameter of a blood vessel using a non-invasive ultrasound...
4866030 Method of producing high temperature superconductors by a molten hydroxide process  
The present invention is directed to a method of producing metal oxides which are useful as high temperature superconductors. The method comprises the steps of: (a) mixing generally stoichiometric...
4859768 Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof  
Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective antiviral agents for pharmaceutical and agricultural use....
4818685 Method and kit for diagnosing bloom's syndrome  
A method and kit for diagnosing Bloom's syndrome are provided relying on specific monoclonal antibodies, such as ATCC HB-9311, which recognize the base excision repair pathway enzyme uracil DNA...
4808088 Pneumatic drive circuit for an artificial ventricle including systolic pressure control  
A pneumatic drive circuit for a pneumatically-driven artificial ventricle having a gas chamber and a blood chamber separated by a flexible diaphragm. The drive circuit comprises a source of...
4807482 Method and apparatus for measuring stimuli applied to a piezoelectric transducer  
A method of and apparatus for measuring a stimulus, e.g. a force, applied to a piezoelectric transducer. The method comprises sampling the output of the transducer in response to the stimulus at...
4806465 Cytoplasmic antigens of candida albicans and methods of using the same  
Two novel hybridoma cell lines, ATCC #HB-8397 and ATCC #HB-8398 produce monoclonal antibody monospecific to a single determinant shared by a set of three closely related cytoplasmic antigens of...
4797234 Production of sustained release composition from salt-form reactants  
Sustained-released delivery forms comprising the reaction product of a Lewis acid salt with a Lewis base salt at the phase interface of their respective aqueous and non-aqueous solution to form an...
4781715 Cardiac prosthesis having integral blood pressure sensor  
An integral blood pressure sensor for a cardiac prosthesis of the type having a fluid chamber and a blood chamber separated by a flexible diaphragm which is actuated by a drive fluid pulsatingly...