Patents and Patent Applications from Stanford University


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9949752 Systems and methods for endoluminal valve creation  
The present application pertains generally to medical systems and methods for creation of an autologous tissue valves within a mammalian body. In some embodiments, a system for creating an...
9946835 Method and system for the use of biomarkers for regulatory dysfunction in disease  
Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These...
9944982 Surface chemistry and deposition techniques  
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface...
9944911 High affinity Sirp-alpha reagents and methods of using  
High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the...
9944630 Dithiolane carbonate monomers and polymers thereof  
1,2-Diothiolane monomers are disclosed, as are polymers and hydrogels comprising the polymers. Processes for preparing the monomers, polymers and compositions are also disclosed. The monomers have...
US20180101255 Methods for multi-touch ultrasonic touchscreens  
A method of multi-touch detection on a touchscreen by imparting Lamb waves inside a touchscreen, using a first ultrasound transducer having a polarization direction positioned to excite lowest...
US20180100865 PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF  
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of...
9939501 Iterative minimization procedure with uncompressed local SAR estimate  
A method for providing an image of a subject in a magnetic resonance imaging MRI system with parallel transmission (pTx) is provided. A localizer scan of the subject is provided. Body anatomy is...
9939376 Method for calibration-free scanned-wavelength modulation spectroscopy for gas sensing  
A method of calibration-free scanned-wavelength modulation spectroscopy (WMS) absorption sensing is provided by obtaining absorption lineshape measurements of a gas sample on a sensor using...
9938579 Biomarker panel for diagnosis and prediction of graft rejection  
Methods are provided for monitoring a subject having a graft for an acute rejection (AR) response, e.g., to predict, to diagnose, and/or to characterize an AR response. In practicing the subject...
US20180094139 2,7-DISUBSTITUTED CEPHALOSPORIN DERIVATIVES AS BETA-LACTAMASE SUBSTRATES AND METHODS FOR THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS  
β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.
US20180093265 Electropermanent magnet activated microfluidic droplet size modulation  
An active microfluidic droplet generation device includes a droplet generation junction joining at least one continuous phase channel for carrying a ferrofluid, and a dispersed phase channel for...
9935208 Energy storage device with large charge separation  
High density energy storage in semiconductor devices is provided. There are two main aspects of the present approach. The first aspect is to provide high density energy storage in semiconductor...
9932607 Site-specific integration of transgenes into human cells  
Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in...
9931522 Methods and systems for beam intensity-modulation to facilitate rapid radiation therapies  
Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and...
US20180086896 BIOMIMETIC, MOLDABLE, SELF-ASSEMBLED CELLULOSE SILICA-BASED TRIMERIC HYDROGELS AND THEIR USE AS VISCOSITY MODIFYING CARRIERS IN INDUSTRIAL APPLICATIONS  
The present invention provides moldable, fully scalable cellulose silica-based hydrogels for use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical...
US20180085570 DEVICE AND METHOD FOR POSITIONING AN ELECTRODE IN TISSUE  
A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and...
9928338 Method and system for phasing individual genomes in the context of clinical interpretation  
The present disclosure presents a unified system to phase a personal genome for downstream clinical interpretation. In an embodiment, an initial phasing is generated using public datasets, such as...
9928150 System and method for testing a logic-based processing device  
A method of operating a test device for a logic-based processing device includes the steps of providing an original set of test instructions, generating one or more Quick Error Detection (QED)...
9927435 Multisite biosensor and associated method  
A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test...
9925308 Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use  
The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is...
US20180082840 Metal oxide-resistive memory using two-dimensional edge electrodes  
Improved resistive random access memory (RRAM) devices are provided that use a 2-D electrode as the SET electrode to take up a variable amount of oxygen from an oxide material, thereby providing a...
US20180080770 OPTICAL SYSTEM AND METHOD UTILIZING A LASER-DRIVEN LIGHT SOURCE WITH WHITE NOISE MODULATION  
An optical system is provided having a laser configured to generate light having a first laser spectrum with a first linewidth, a waveform generator configured to produce a noise waveform, and an...
9923111 Illumination and radiative cooling  
Aspects of the present disclosure are directed to providing and/or controlling electromagnetic radiation. As may be implemented in accordance with one or more embodiments, an apparatus includes a...
9921283 Methods for detecting abnormalities and degenerative processes in soft tissue using magnetic resonance imaging  
The present invention provides methods to detect degenerative processes and abnormalities in soft tissues at high spatial resolution, high signal-to-noise ratio and short scanning times, based on...
9920300 Induction of germ cells from pluripotent cells  
Methods and compositions are provided for promoting germ cell differentiation from pluripotent cells, and for identifying agents that modulate germ cell differentiation.
9918964 Reducing platelet activation, aggregation and platelet-stimulated thrombosis or blood coagulation by reducing mitochondrial respiration  
It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more...
US20180073942 Capacitive Force/Torque Sensor  
A capacitive force sensor is provided that includes a first support layer and a second support layer, a dielectric layer disposed between the first support layer and the second support layer,...
US20180071540 Wireless Midfield Systems and Methods  
Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target...
US20180071079 METHODS OF TREATING A MUSCULOSKELETAL TISSUE INTERFACE INJURY USING DECELLULARIZED COMPOSITE TISSUE BIOSCAFFOLDS  
Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.
US20180070870 Autonomous Sweat Extraction and Analysis Using a Fully-Integrated Wearable Platform  
A device for on-demand sweat extraction and analysis is realized as a printed circuit comprising a microcontroller, an iontophoresis circuit, a sensing circuit, and an electrode array having...
9913826 Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are...
US20180068178 Real-time Expression Transfer for Facial Reenactment  
A computer-implemented method for tracking a human face in a target video includes obtaining target video data of a human face; and estimating parameters of a target human face model, based on the...
US20180067126 PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF  
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of...
US20180067038 DEVICES AND METHODS FOR HIGH-THROUGHPUT SINGLE CELL AND BIOMOLECULE ANALYSIS AND RETRIEVAL IN A MICROFLUIDIC CHIP  
Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a...
9909180 Measurement and comparison of immune diversity by high-throughput sequencing  
High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global...
9909167 On-slide staining by primer extension  
A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the...
9908918 Cyan-excitable orange-red fluorescent proteins and bioluminescent resonance energy transfer systems  
Engineered orange-red fluorescent proteins with enhanced fluorescent properties, obtained by mutagenesis of mNeptune2, are disclosed. In particular, the invention relates to engineered orange-red...
9908266 Mold fabrication method for gecko-inspired adhesives  
A method of forming synthetic dry adhesives is provided that includes using a combined wedge indenting and orthogonal machining process to form tapered mold cavities in a mold, filling the tapered...
9907929 Method and device for monitoring and treating sleep disorders and sleep-related conditions  
Methods and apparatus for monitoring, diagnosing, and treating sleep disorders such as sleep terrors are provided, which may include any number of features. One feature is an apparatus configured...
9907471 Visualization of heart wall tissue  
Various aspects of the instant disclosure are directed to imaging tissue. As may be implemented in accordance with one or more embodiments, aspects of the present disclosure are directed to...
9903262 Stoichiometric high-temperature direct-injection compression-ignition engine  
A neat-fuel direct-injected compression ignition engine having a thermal barrier coated combustion chamber, an injection port injects fuel that satisfies a stoichiometric condition with respect to...
9902957 Amphipathic co-oligomers for the delivery of siRNA  
Co-oligomer compounds, complexes of the same with polyanions, such as siRNAs, and methods for using the same are provided. the delivery of polynucleotides, into a cell. The subject co-oligomers...
US20180052162 METHOD TO DETECT THE ONSET AND TO MONITOR THE RECURRENCE OF CHRONIC GRAFT VERSUS HOST DISEASE IN TRANPLANTATION PATIENTS  
The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises...
9897394 Subsurface thermal energy storage of heat generated by concentrating solar power  
Techniques for subsurface thermal energy storage of heat generated by concentrating solar power enable smoothing of available energy with respect to daily and/or seasonal variation. Solar thermal...
US20180043062 Customized load-bearing and bioactive functionally-graded implant for treatment of osteonecrosis  
An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical...
US20180043040 IMAGING TUMOR GLYCOLYSIS BY NON-INVASIVE MEASUREMENT OF PYRUVATE KINASE M2  
The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphen yl)sulfonyl)piperazine ([18F]DASA-23) probe that can...
9891213 Granulocyte-based methods for detecting and monitoring immune system disorders  
Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen. Methods are also provided for determining and monitoring a subject's...
9889087 Intranasal delivery of β2-adrenergic receptor agonists for improving cognition in humans with down syndrome and compositions therefor  
A method of improving cognition in a patient with Down syndrome, which entails intranasally administering one or more β2-ADR agonists or pharmaceutically-acceptable salts of either or both to the...
9889046 Skin treatment devices and methods with pre-stressed configurations  
Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a...