Patents and Patent Applications from Stanford University


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US20180017518 Nanogrid electrochemical sensor for detection of biochemical species by electrochemical impedance spectroscopy  
Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic...
US20180016601 Methods for Modulating Genome Editing  
Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or...
9871183 Electrostrictive element  
The present invention provides an electrostrictive element capable of preventing breakdown of a dielectric film. An electrostrictive element 1 includes a dielectric film 2 composed of an...
9869648 High density grids  
An X-ray data collection grid device is provided that includes a magnetic base that is compatible with robotic sample mounting systems used at synchrotron beamlines, a grid element fixedly...
US20180008643 Vivo Iron Labeling of Stem Cells and Tracking these Labeled Stem Cells after their Transplantation  
Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (MSCs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (MR) imaging. The...
9865789 Device and method for thermoelectronic energy conversion  
A thermoelectronic energy converter device (100) comprises an electron emitter (11) being adapted for a temperature-dependent release of electrons (1), an electron collector (21) being adapted for...
9864190 Confocal microscope, system and method therefor  
Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments,...
9863959 Protein binding domains stabilizing functional conformational states of GPCRS and uses thereof  
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of...
9863939 Analyte detection with magnetic sensors  
Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a...
9863057 Coated substrate apparatus and method  
A coated substrate is formed with aligned objects such as small molecules, macromolecules and nanoscale particulates, such as inorganic, organic or inorganic/organic hybrid materials. In...
9861834 Station parameter optimized radiation therapy (SPORT): a novel scheme for treatment planning and delivery in radiation therapy  
A method of radiation therapy planning and delivery is provided that includes introducing a demand metric, using a volumetric modulation arc therapy system, to select a spatially optimized and...
9861272 Apparatus, systems, and methods for performing laparoscopic surgery  
Apparatus, systems, and methods for laparoscopic abdominal surgery are disclosed. For example, a system or kit is provided for performing a procedure within a surgical space within a patient's...
US20180002760 Molecular Analysis using a Magnetic Sifter and Nanowell System  
A method for identification of circulating tumor cells (CTCs) in a blood sample uses magnetic enrichment and a nanowell assay. The CTCs are magnetically labeled with cancer cell markers conjugated...
US20180002375 PROTEASE-ACTIVATED CONTRAST AGENTS FOR IN VIVO IMAGING  
Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases...
9859097 Vacuum tube electron microscope  
A permanently sealed vacuum tube is used to provide the electrons for an electron microscope. This advantageously allows use of low vacuum at the sample, which greatly simplifies the overall...
9858691 Statistical data acquisition model for GPU based MLEM joint estimation of tissue activity distribution and photon attenuation map from PET data  
We provide improved maximum likelihood expectation maximization (MLEM) joint estimation of emission activity and photon attenuation from positron emission tomography (PET) data. Lines of response...
9857868 Method and system for ergonomic touch-free interface  
With the advent of touch-free interfaces such as described in the present disclosure, it is no longer necessary for computer interfaces to be in predefined locations (e.g., desktops) or...
9857446 Robust self-navigating MRI using large coil arrays  
A method for providing at least one motion corrected magnetic resonance imaging (MRI) image of an object in an MRI system with an array of a plurality of receiving coils is provided. At least one...
9856469 AAV capsid proteins for nucleic acid transfer  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are...
9856448 Devices and methods for long-term intracellular access  
Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be...
9855421 Device and method for positioning an electrode in tissue  
A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and...
9850483 Methods and systems for analysis of single cells  
Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and...
9849198 Discrete imaging of hepatic oxidative and nitrosative stress with two-channel nanoparticles for in vivo drug safety screening  
Encompassed are embodiments of activatable nanoprobes useful for in vivo longitudinal imaging of drug hepatotoxicity with oxidative and nitrosative stress as the safety biomarkers. Both H2O2 and...
US20170367171 Apparatus for mm-wave radiation generation utilizing whispering gallery mode resonators  
An apparatus for generating high frequency electromagnetic radiation includes a whispering gallery mode resonator, coupled to an output waveguide through a coupling aperture. The resonator has a...
US20170360965 IMMUNO-THERAPY FOR CANCER TREATMENT USING IRON OXIDE NANOPARTICLES  
An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle is administered to a tumor. Once the...
9845497 Non-invasive diagnosis of graft rejection in organ transplant patients  
The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
9844663 Device and method for positioning an electrode in tissue  
A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and...
9844607 Immuno imaging agent for use with antibody-drug conjugate therapy  
The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for in vivo detection and...
US20170358079 SYSTEMS, METHODS AND DEVICES FOR ANALYZING QUANTITATIVE INFORMATION OBTAINED FROM RADIOLOGICAL IMAGES  
An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the...
US20170354832 Trajectory Optimization in Radiotherapy Using Sectioning  
A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where...
US20170354816 Devices for delivery of electrical current to the body and related methods for therapy  
A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a...
US20170354812 DRAINAGE DEVICES AND METHODS FOR USE  
Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct. The device can have a port for withdrawing lymph fluid...
9842707 Bamboo-inspired nanostructure design for flexible, foldable and twistable energy storage devices  
A flexible all-solid state supercapacitor is provided that includes a first electrode and a second electrode, and a flexible nanofiber web, where the flexible nanofiber web connects the first...
9841481 Multislice acquisition with incoherent aliasing  
A method for producing images of a subject with a MRI system is provided. A radio frequency (RF) excitation field in combination with a slice-select magnetic gradient field along a slice-select...
9839771 Expandable guide sheath and apparatus and methods for using such sheaths  
Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is...
US20170353401 DRAGONFLY PROCESSOR INTERCONNECT NETWORK  
A multiprocessor computer system comprises a dragonfly processor interconnect network that comprises a plurality of processor nodes, a plurality of routers, each router directly coupled to a...
US20170348525 Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms  
A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects...
9835613 Rapid small volume detection of blood ammonia  
A method for measuring ammonia in a blood sample may involve positioning the blood sample in proximity with an ammonia gas sensor, generating a current with the ammonia gas sensor in response to...
9834681 2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis  
β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.
9833623 Apparatus and methods for treating pulmonary hypertension  
A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate...
9833144 Probes, methods of making probes, and methods of use  
Embodiments of the present disclosure provide for probes, methods of using the probe, methods of making the probe, method of imaging a condition (e.g., pre-cancerous tissue, cancer, or a tumor),...
US20170346013 POLYMER AND ELECTRONIC DEVICE AND ORGANIC THIN FILM TRANSISTOR INCLUDING THE SAME  
A polymer includes a first repeating unit and a second repeating unit forming a main chain, the first repeating unit including at least one first conjugated system, and the second repeating unit...
US20170340608 Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin Amyloidosis and Protein-Protein Interactions  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are...
9827005 Systems and methods for endoluminal valve creation  
The present application pertains generally to medical systems and methods for creation of an autologous tissue valves within a mammalian body. In some embodiments, a system for creating an...
9823246 Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon  
Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced...
9821159 Stimulation devices and methods  
Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a...
9820652 Multi-photon microscope having an excitation-beam array  
A two-photon imaging system capable of imaging of an image region in real time is presented. The imaging system comprises a source of excitation light that provides the excitation light as a...
US20170325697 PROBE FOR DETECTING ATHEROSCLEROSIS  
A probe device for detecting atherosclerotic plaque may include: an elongate shaft having a proximal end for coupling with a catheter and a distal end; an opening in a side of the shaft; a...
9816066 Method for delivery of small molecules and proteins across the cell wall of algae using molecular transporters  
The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular...
9815881 Method of inducing labor or treating pre-eclampsia by administering relaxin analogs  
Human relaxin analogs, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided.