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Patents and Patent Applications from Stanford University


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US20130324878 Method of Sonifying Brain Electrical Activity  
A digital processor system having one or more processors and memory obtains a time-domain signal representing brain activity, the time-domain signal having a time varying signal value. The system...
US20130324707 SYNTHETIC AMPHIPHILES FOR MEMBRANE PROTEIN MANIPULATION  
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily...
US20130323281 ORDERED FLAGELLIN ARRAY AS AN IMMUNOSTIMULANT  
Bacterial flagellin protein is modified to improve adjuvant activity.
US20130323171 RADIOLABELED BBN ANALOGS FOR PET IMAGING OF GASTRIN-RELEASING PEPTIDE RECEPTORS  
Radiolabeled bombesin (BBN) analogs that bind to the gastrin-releasing peptide receptor (GRPR) represent a topic of active investigation for the development of molecular probes for positron...
8600513 Seizure prediction and neurological disorder treatment  
A prediction and stimulation system or method is provided for neurological disorders characterized by a local dysfunction in neuronal activity regulation. An array of electrodes detects neuronal...
8597717 Oriented collagen gel  
Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to...
US20130318092 Method and System for Efficient Large-Scale Social Search  
To answer search queries on a social network rich with user-generated content, it is desirable to give a higher ranking to content that is closer to the individual issuing the query. Queries occur...
US20130317575 Implantable Optical Stimulators  
Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an...
US20130317569 Optogenetic Control of Reward-Related Behaviors  
Provided herein are compositions and methods for disrupting at least one reward-related behavior in an individual through the use of light-responsive opsin proteins used to control the polarization...
US20130317553 METHODS AND SYSTEMS FOR CONSTRAINT OF SPINOUS PROCESSES WITH ATTACHMENT  
Spinal implants for limiting flexion of the spine are implanted between a superior spinous process and an inferior spinous process or sacrum. The implants include upper straps which are placed over...
US20130317088 Selective Reduction of the Deleterious Activity of Extended Tri-Nucleotide Repeat Containing Genes  
Aspects of the invention include methods of selectively reducing the deleterious activity of mutant extended trinucleotide repeat containing genes in a cell, as well as compositions used in such...
US20130316921 METHODS FOR DIAGNOSIS OF KAWASAKI DISEASE  
Methods for diagnosis of Kawasaki disease (KD) are disclosed. In particular, the invention relates to the use of biomarkers for aiding diagnosis, prognosis, and treatment of KD, and more...
US20130316397 Cell-Free Polypeptide Synthesis  
Methods, microbial strains and reaction mixtures for cell-free synthesis of polypeptides are provided. The methods of the invention utilize a reaction mixture comprising microbial cell extracts...
8592227 Hybrid quantum dot/protein nanostructure, methods of making, and methods of use thereof  
Embodiments of the present disclosure include hybrid quantum dot/protein nanostructure, hybrid quantum dot/protein nanostructure systems, methods of using hybrid quantum dot/protein nanostructures,...
8592225 Array-based bioactivated nanopore devices  
A nanopore device capable of single molecule detection is described. The nanopores are formed in thin, rigid membranes and modified by a sputtered metal that forms an overhang during application....
US20130312126 Methods and Compositions for RNAi Mediated Inhibition of Gene Expression in Mammals  
Methods and compositions are provided for modulating, e.g., reducing, coding sequence expression in mammals. In the subject methods, an effective amount of an RNAi agent, e.g., an interfering...
US20130310700 SYSTEMS AND METHODS FOR MONITORING THE CIRCULATORY SYSTEM  
In accordance with embodiments of the present disclosure, a ballistocardiogram (BCG) sensor is used to detect heart and vascular characteristics of a user, and provide a BCG output indicative of...
US20130310347 MULTI-MODALITY MOLECULAR IMAGING HIGH-THROUGHPUT ASSAY FOR IDENTIFYING HEAT SHOCK PROTEIN 90 (HSP90) INHIBITORS  
High throughput methods for identifying novel inhibitors of Hsp90 chaperone protein folding are disclosed. The inhibitors so identified disrupt the binding of p23 to either Hsp90α or Hsp90β and h...
US20130309657 DEVICES AND METHODS FOR SEPARATING PARTICLES  
Embodiments of the present disclosure provide for particle-imprinted polymer films, methods of making particle-imprinted polymer films, methods for separating particles, devices or systems for...
US20130308756 Apparatus and Method for Nanoflow Liquid Jet and Serial Femtosecond X-ray Protein Crystallography  
Techniques for nanoflow serial femtosecond x-ray protein crystallography include providing a sample fluid by mixing a plurality of a first target of interest with a carrier fluid and injecting the...
US20130307025 TRANSISTOR-BASED APPARATUSES, SYSTEMS AND METHODS  
Various aspects of the invention are directed to memory circuits and their implementation. According to an example embodiment, an apparatus includes a channel region between raised source and drain...
US20130306929 Multilayer-Stacked Phase Change Memory Cell  
A multilayer-stacked phase change memory (PCM) device is provided that includes a substrate that is electrically insulative and thermally conductive, a number (n) of PCM layers deposited on the...
8589387 Information extraction from a database  
Techniques for extracting information from a database are provided. A database such as the Web is searched for occurrences of tuples of information. The occurrences of the tuples of information...
8587311 Multi-channel breast MRI radio frequency receiver coil  
A system and method for breast imaging is disclosed. The system is constructed as a modular RF coil system for an MR imaging apparatus and includes a fitted coil former constructed to have a shape...
8586305 Profiling of cell populations  
Understanding the heterogeneity within a stem cell population remains a major impediment to the development of clinically effective cell-based therapies. Gene expression patterns exhibited by...
8586294 Detection of protein translocation by beta-galactosidase reporter fragment complementation  
Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between subcellular copartments, using at least two components that...
8585973 Nano-sensor array  
In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of...
US20130303599 IRE1ALPHA ENDONUCLEASE SPECIFIC INHIBITOR WITH CYTOTOXIC ACTIVITY  
Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and hematological malignancies, including multiple myeloma (MM). What is disclosed is STF-083010, a novel small...
US20130301488 SYSTEMS AND METHODS FOR CANCELLING INTERFERENCE USING MULTIPLE ATTENUATION DELAYS  
A wireless communication device includes, in part, at least one antenna for receiving or transmitting a signal, and a cancelation circuit adapted to cancel or reduce the self-interference signal....
US20130299707 OPTICAL COUPLING TECHNIQUE FOR CONTIGUOUS MONOLITHIC SCINTILLATION CRYSTAL DETECTORS  
Embodiments of the invention provide a high energy photon detector. A first scintillation crystal is provided. A first plurality of photosensors is on a first face of the first scintillation...
8580504 Methods and compositions for use in analyte detection using proximity probes  
Methods and compositions for detecting an analyte in a sample are provided. In practicing the subject methods, a sample is combined with at least a pair of proximity probes that each include an...
US20130297221 Method and System for Accurate Construction Of Long Range Haplotype  
In an embodiment of the present invention, a modified version of the PHASE model is implemented that is substantially more accurate than the FastPHASE model. Modifications in an embodiment of the...
US20130296430 COMPOSITIONS AND METHODS FOR TREATING AUTISM AND AUTISM SPECTRUM DISORDER  
The described invention provides a method for treating a behavioral deficit, such as irritability and stereotypic/repetitive behaviors, in a subject with autism spectrum disorder by administering a...
US20130296406 Optically-Based Stimulation of Target Cells and Modifications Thereto  
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule...
US20130296349 QUINAZOLINONE INHIBITORS OF DYNEIN  
Compounds of formula (I) in which R3 is chosen from hydrogen, cyano, nitro, acetyl and C(═O)NH2, and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl, are useful as a...
US20130295635 System for Optical Stimulation of Target Cells  
Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the...
US20130295376 Coated Biodegradable Building Article  
A composite material includes a matrix composed of a polyhydroxyalkanoate (PHA) polymer and a filler composed of particles dispersed in the matrix. The particles are composed of naturally-derived...
US20130295015 Optically-Controlled CNS Dysfunction  
Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive...
US20130294722 Practical multiply resonant photonic crystal nanocavity  
Intersecting photonic crystal structures provide overlapping cavity modes that can have widely separated resonant frequencies. These photonic crystal structures can be either 1-D photonic crystal...
US20130292788 Self-aligned Semiconductor Ridges in Metallic Slits as a Platform for Planar Tunable Nanoscale Resonant Photodetectors  
A photodetector having a ridge-in-slit geometry is provided, where a semiconductor ridge is laterally sandwiched in a metallic slit. This assembly is disposed on a layer of semiconducting material,...
8575534 Cross-strip charge multiplexing readout for differential detector arrays with capacitive row and column charge splitters  
An array of two-terminal detectors is configured to provide output signals that provide position sensitive radiation detection (e.g., outputs A and B provide vertical position and outputs C and D...
8574842 Direct molecular diagnosis of fetal aneuploidy  
Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses...
8574583 AAV capsid library and AAV capsid proteins  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
8574547 Photoacoustic probes and methods of imaging  
Embodiments of the present disclosure provide for photoacoustic probes, methods of determining the presence and location of a specific target, methods of determining the presence and location of an...
US20130289676 Methods, Systems and Devices for Optical Stimulation of Target Cells Using an Optical Transmission Element  
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one such device, target cells are stimulated using an implantable device. The...
US20130289675 Materials and Approaches for Optical Stimulation of the Peripheral Nervous System  
A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is...
US20130289669 Optical Tissue Interface Method and Apparatus For Stimulating Cells  
In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber...
US20130289386 Optogenetic Magnetic Resonance Imaging  
Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell...
US20130288917 Rapid High Resolution, High Throughput RNA Structure, RNA-Macromolecular Interaction, and RNA-Small Molecule Interaction Mapping  
Compositions and methods are provided for a rapid, high-resolution, high-throughput method for determining the intramolecular interactions between the nucleotides present in an polynucleotide, such...
US20130288365 Cell Line, System and Method for Optical-Based Screening of Ion-Channel Modulators  
A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are...