Patents and Patent Applications from Stanford University


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US20150141846 SYSTEM AND METHOD USEFUL FOR SARCOMERE IMAGING VIA OBJECTIVE-BASED MICROSCOPY  
Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to...
US20150140665 Site-Specific Integration of Transgenes into Human Cells  
Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in...
US20150139262 Photonic micro-structured vacuum-ultraviolet radiation source based on solid-state frequency conversion  
A coherent extreme ultraviolet (XUV) radiation source is provided that includes a non-linear optical conversion material solid substrate disposed for nonlinear conversion of infrared (IR) coherent...
US20150136214 Solar cells having selective contacts and three or more terminals  
Junction-less solar cells having three or more terminals are provided. Electron- and hole-selective contacts and interfaces are used in combination with two or more absorber layers having...
US20150133390 Identification of New Therapeutic Uses for Known Therapeutic Agents  
Methods for identifying new therapeutic activities for known therapeutic agents, as well as systems for practicing the same, are provided. Aspects of the invention further include are methods and...
US20150133387 Modulation of Synaptogenesis  
Soluble proteins, e.g. Hevin, can trigger synapse formation; and other soluble proteins, e.g. SPARC antagonize this activity. Such proteins are synthesized in vitro and in vivo by astrocytes....
US20150133317 IDENTIFICATION OF POLYNUCLEOTIDES ASSOCIATED WITH A SAMPLE  
Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two...
US20150132774 FLUORESCENT PROTEIN VOLTAGE SENSORS FOR MEASURING MEMBRANE POTENTIAL AND IMAGING HIGH-FREQUENCY NEURONAL ELECTRICAL ACTIVITY  
Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity are disclosed. In particular, the invention relates to engineered...
US20150132331 Influenza Vaccine Constructs  
Vaccine compositions and methods of producing and using the same are provided, which compositions comprise a modified HA stem domain in a trimeric configuration.
US20150132231 SURFACE FUNCTIONALIZATION OF SUPERPARAMAGNETIC NANOPARTICLES FOR BIOLOGICAL ENCAPSIDATION  
Method and compositions are provided that relate to superparamagnetic nanoparticles, including IONP with small diameter and high transverse relaxivity, that are stable in an aqueous environment....
9029015 High rate, long cycle life electrochemical energy storage devices  
An electrochemical energy storage device includes a cathode, an anode, and an electrolyte disposed between the cathode and the anode. The anode includes a capacitive material as a majority...
9028391 Apparatus and methods for treating pulmonary hypertension  
A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate...
US20150126861 WEARABLE ULTRASONIC DEVICE FOR CIRCULATING TUMOR CELL DETECTION  
An apparatus for detecting circulating tumor cells is provided. A support system for mounting on a patient is provided. An imaging system is attached to the support system. The imaging system...
US20150126622 Blood Biomarkers for Necrotizing Enterocolitis  
Necrotizing Enterocolitis (NEC) biomarkers, NEC biomarker panels, and methods for obtaining a NEC signature for a sample are provided. Also provided are methods, compositions, and kits for making...
US20150126532 Identification of Stabilizers of Multimeric Proteins  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are...
US20150125890 IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS  
Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or...
US20150123105 OFF-CENTER SPIN-COATING AND SPIN-COATED APPARATUSES  
Various aspects of the instant disclosure are directed to methods and to apparatuses involving spin-coating and spin-coated materials. As may be implemented in connection with one or more...
9025456 Speculative reservation for routing networks  
Aspects relate to methods, devices and manufacturing relating to routing networks including a method for routing data units. The data units are individually routable through a routing network. A...
9025157 System and method for measuring perturbations using a slow-light fiber Bragg grating sensor  
An optical device, a method of configuring an optical device, and a method of using a fiber Bragg grating is provided. The optical device includes a fiber Bragg grating, a narrowband optical...
9023084 Systems and methods for stabilizing the motion or adjusting the position of the spine  
Systems and methods for stabilizing or adjusting the position of at least one spinal motion segment, such as a posterior element distraction system. The system includes an implantable member...
US20150119694 Simultaneous attenuation and activity reconstruction for Positron Emission Tomography  
A method of PET image reconstruction is provided that includes obtaining intra-patient tissue activity distribution and photon attenuation map data using a PET/MRI scanner, and implementing a...
US20150118831 Method of Fabricating Thin, Freestanding, Single Crystal Silicon Sheet  
A method of forming a free-standing silicon film that includes providing a Si substrate, depositing a layered structure on the Si substrate, where the layered structure includes a Si device layer...
US20150118704 METHOD FOR DELIVERY OF SMALL MOLECULES AND PROTEINS ACROSS THE CELL WALL OF ALGAE USING MOLECULAR TRANSPORTERS  
The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular...
US20150118157 Compounds and Methods of Making Compounds  
Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIGS. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2′, 4′, and...
9019482 Optical device with fiber Bragg grating and narrowband optical source  
In certain embodiments, an optical device and a method of use is provided. The optical device includes a fiber Bragg grating having a substantially periodic refractive index modulation along a...
9018603 Pluridirectional very high electron energy radiation therapy systems and processes  
A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using...
9018579 Atom interferometry having spatially resolved phase  
In an atom interferometer, improved results are obtained by configuring the interferometer to have a baseline fringe pattern, in combination with spatially resolved measurements at the...
9018179 Methods and compositions for RNAi mediated inhibition of gene expression in mammals  
Methods and compositions are provided for modulating, e.g., reducing, expression of a target sequence in mammals and mammalian cells. In the subject methods, an effective amount of an RNAi agent,...
9017675 Humanized and chimeric monoclonal antibodies to CD47  
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating...
9014988 Apparatus and method for determining microscale interactions based on compressive sensors such as crystal structures  
Techniques for determining values for a metric of microscale interactions include determining a mesoscale metric for a plurality of mesoscale interaction types, wherein a value of the mesoscale...
9014231 Vertical cavity surface emitting laser nanoscope for near-field applications  
A vertical cavity surface emitting laser (VCSEL) nanoscope is provided. The VCSEL nanoscope combines a VCSEL with a nano-scale aperture using a support member to separate the aperture from the...
9012087 Device and electrode having nanoporous graphite with lithiated sulfur for advanced rechargeable batteries  
Methods, systems and devices are implemented in connection with rechargeable batteries. One such device includes a cathode that has lithiated sulfur. The device also includes a porous structure...
9011914 Hetero-assembled hydrogels  
A two-component, molecular-recognition gelation strategy that enables cell encapsulation without the need for environmental triggers is provided. The two components, which in one example contain...
9011882 Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof  
The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or...
9011817 Compounds and methods of making compounds  
Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIGS. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2′, 4′, and...
9011346 Systems and methods for monitoring the circulatory system  
In accordance with embodiments of the present disclosure, a ballistocardiogram (BCG) sensor is used to detect heart and vascular characteristics of a user, and provide a BCG output indicative of...
US20150105456 Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof  
The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The...
US20150104828 Levels and/or Sustainability of DNA-based Gene Expression  
The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to...
US20150104793 NON-INVASIVE FETAL GENETIC SCREENING BY DIGTAL ANALYSIS  
The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample....
US20150103315 i-DDrOP: Interfacial Dewetting and Drainage Optical Platform  
An interfacial dewetting and drainage optical platform (i-DDrOP) is provided which is an instrument that can quantify drainage and dewetting processes of in vitro model tear films covering contact...
US20150102830 ELECTRO-DIFFUSION ENHANCED BIO-MOLECULE CHARGE DETECTION USING ELECTROSTATIC INTERACTION  
According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width...
US20150102465 Material quality, suspended material structures on lattice-mismatched substrates  
Suspended structures are provided using selective etch technology. Such structures can be protected on all sides when the selective undercut etch is performed, thereby providing excellent control...
9008378 Arrangement and imaging of biological samples  
High-resolution three-dimensional imaging of a specimen is facilitated. According to an example embodiment of the present invention, a series of very thin slices from a specimen are serially and...
9005619 Methods for enhancing anti-tumor antibody therapy  
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by...
9005100 Apparatus and methods for treating pulmonary hypertension  
A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate...
US20150099655 Methods and Compositions for Providing a Preeclampsia Assessment  
Preeclampsia markers, preeclampsia marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided. These compositions and methods find use in a...
US20150099187 LARGE-VOLUME-CHANGE LITHIUM BATTERY ELECTRODES  
A battery electrode material includes: 1) primary particles formed of an electrochemically active material; and 2) a secondary particle defining multiple, discrete internal volumes, wherein the...
US20150099150 ELECTROCHEMICAL SYSTEMS AND METHODS FOR HARVESTING HEAT ENERGY  
Electrochemical systems for harvesting heat energy, and associated electrochemical cells and methods, are generally described.
9002428 Methods for detecting abnormalities and degenerative processes in soft tissue using magnetic resonance imaging (MRI)  
The present invention provides methods to detect degenerative processes and abnormalities in soft tissues at high spatial resolution, high signal-to-noise ratio and short scanning times, based on...
9001923 Performance prediction in communication systems  
Methods and apparatus, including computer program products, are provided performance prediction. In one aspect there is provided a method. The method may include receiving information including...