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Patents and Patent Applications from Stanford University


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US20140161786 Therapeutic compositions and related methods  
The present invention generally relates to therapeutic compositions for the treatment of mammalian disease and related methods. It more specifically relates to compositions comprising peptides for...
8750652 Microfluidic waveguide detector  
A microfluidic detection device is provided that includes a planar waveguide, or an ion-exchange planar waveguide, a microfluidic channel disposed on the planar waveguide, a light source, such as a...
8748904 Low loss nano-aperture  
Low loss optical apertures are provided. A silicon intermediate layer sandwiched between a metal aperture layer and a dielectric layer has been found to offer a good combination of low optical loss...
8748404 DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus  
A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further...
8748354 RNA interactome analysis  
A method of sample analysis is provided. In certain cases, the method comprises: a) cross-linking the contents of a cell using a heat stable crosslinking agent to produce cross-linked...
8748338 Polysulfide-rubber-coated activated carbon (PSR-AC) as a multi-sorbent for mercury and polychlorinated biphenyls (PCBS)  
A toxin immobilization particle and method of fabrication is provided that includes a polysulfide-rubber polymer coated activated carbon particle that provides enhanced toxin adsorption. A porous...
US20140155329 Long-Acting Peptide Analogs  
Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo.
US20140154673 PROBES OF RNA STRUCTURE AND METHODS FOR USING THE SAME  
Methods for obtaining structural data from RNA in a sample, and RNA probes for performing the same, are provided. Methods of reversibly modifying RNA is a sample, in vitro or in vivo, and...
8741860 Modulation of T cell signaling threshold and T cell sensitivity to antigens  
MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the ...
8741839 Polypeptides targeting vascular endothelial growth factor receptor-2 and αvβ3 integrin  
Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as...
US20140148880 Upconversion of Light for Use in Optogenetic Methods  
Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths into the visible light spectrum. Also...
US20140148351 Prediction of Clinical Outcome in Hematological Malignancies Using a Self-Renewal Expression Signature  
Methods, compositions, and kits are provided for providing a diagnosis, a prognosis, or a prediction of responsiveness to a therapy for a patient with a hematological malignancy. In practicing the...
US20140148346 METHODS OF IDENTIFYING AND CLASSIFYING ORGANOHALIDE-RESPIRING BACTERIA  
Briefly described, embodiments of the present disclosure relate to methods and systems for identifying and classifying taxa of organohalide-respiring bacteria, including methods and systems for...
8735609 Bryostatin analogues, synthetic methods and uses  
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or improved recognition domains are disclosed, including methods of preparing and...
8735286 Deposition-free sealing for micro- and nano-fabrication  
A method for sealing through-holes in a material via material diffusion, without the deposition of a sealant material, is disclosed. The method is well suited to the fabrication and packaging of...
8735096 Optical control of protein activity and localization by fusion to photochromic protein domains  
Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent...
US20140142437 SYSTEMS AND METHODS FOR MONITORING HEART FUNCTION  
Characteristics of a user's heart are detected. In accordance with an example embodiment, a ballistocardiogram (BCG) sensor is used to detect heart characteristics of a user, and provide a BCG...
US20140141449 Autoantibody Biomarkers for IGA Nephropathy  
Aspects of the present invention include methods for diagnosing and monitoring IgAN in a subject. In practicing one aspect of the subject methods, a sample from a subject is analyzed for the...
US20140141061 Use of WNT Agents to Prevent Hypoxic Injury  
Methods and compositions are provided for the therapeutic use of Wnt proteins or Wnt agonists in protecting tissue from the adverse effects of hypoxia.
US20140140930 NON-PEPTIDIC QUENCHED FLUORESCENT IMAGING PROBES  
Methods and materials for the imaging of cells and tissues containing active proteases such as cathepsin are disclosed. The present materials include activity based probes that bind to an enzyme...
US20140140514 Fully Homomorphic Encryption Method Based On A Bootstrappable Encryption Scheme, Computer Program And Apparatus  
A method includes encrypting information in accordance with an encryption scheme that uses a public key; encrypting a plurality of instances of a secret key, each being encrypted using at least one...
US20140138612 FULLERENE-DOPED NANOSTRUCTURES AND METHODS THEREFOR  
Nanostructures are doped to set conductivity characteristics. In accordance with various example embodiments, nanostructures such as carbon nanotubes are doped with a halogenated fullerene type of...
8731844 System and method for selecting a multiparameter reagent combination and for automated fluorescence compensation  
The invention provides a system and method for selecting an optimal multimarker reagent combination for the identification and/or quantification of molecules in or on cells with or without...
8729486 MODFET active pixel X-ray detector  
Detection of ionizing radiation with modulation doped field effect transistors (MODFETs) is provided. There are two effects which can occur, separately or together. The first effect is a direct...
8729067 Pharmacological treatment of cognitive impairment  
Methods for treating an individual to improve cognitive function are provided. In the subject methods, an effective amount of a noncompetitive GABAA ionophore blocker is administered to the...
8729040 Cell line, system and method for optical control of secondary messengers  
A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for...
8728793 Amphipathic alpha-helical peptide compositions as antiviral agents  
The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a...
US20140135797 POSITIONING APPARATUS AND METHOD OF USE  
A positioning system having a base, a manually movable end effector and a first joint interposed between the base and the end effector is disclosed. The first joint may comprise a proximal portion...
US20140135563 PLURIDIRECTIONAL VERY HIGH ELECTRON ENERGY RADIATION THERAPY SYSTEMS AND PROCESSES  
A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using...
US20140135358 Use of FK506 for the Treatment of Pulmonary Arterial Hypertension  
A method of reducing pulmonary arterial hypertension in a mammal that employs FK506 is provided. In certain embodiments, the method comprises administering FK506 to a mammal having pulmonary...
US20140134733 CHEMICALLY DEFINED PRODUCTION OF CARDIOMYOCYTES FROM PLURIPOTENT STEM CELLS  
Methods are provided for producing a cardiomyocyte population from a mammalian pluripotent stem cell population. Aspects of the methods include using a Wnt signaling agonist and antagonist, each in...
US20140134613 Direct Molecular Diagnosis of Fetal Aneuploidy  
Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses...
US20140134167 Transforming growth factor-beta (TGF-beta) antagonists for use in treating pain  
Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-β antagonist. In some embodiments, a TGF-β antagonist is a m...
US20140134145 METHOD TO INDUCE AND EXPAND THERAPEUTIC ALLOANTIGEN-SPECIFIC HUMAN REGULATORY T CELLS IN LARGE-SCALE  
Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25− T...
US20140133740 INTELLIGENT PART IDENTIFICATION FOR USE WITH SCENE CHARACTERIZATION OR MOTION CAPTURE  
A variety of methods, systems, devices and arrangements are implemented for use with motion capture. One such method is implemented for identifying salient points from three-dimensional image data....
US20140133279 Energy Harvesting  
As may be implemented in accordance with one or more embodiments, an apparatus and/or method involves a plurality of transducer elements that convert energy waves conveyed via a multi-directional...
US20140131769 SILICON-COMPATIBLE COMPOUND JUNCTIONLESS FIELD EFFECT TRANSISTOR  
The present invention provides a silicon-compatible compound junctionless field effect transistor enabled to be compatible to a bulk silicon substrate for substituting an expensive SOI substrate,...
US20140131023 STRUCTURES FOR RADIATIVE COOLING  
Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a...
US20140130597 GYROSCOPE UTILIZING TORSIONAL SPRINGS AND OPTICAL SENSING  
A gyroscope and a method of detecting rotation are provided. The gyroscope includes a structure configured to be driven to move about a drive axis. The structure is further configured to move about...
8725726 Scoring documents in a linked database  
A method assigns importance ranks to nodes in a linked database, such as any database of documents containing citations, the world wide web or any other hypermedia database. The rank assigned to a...
8722017 Fluorescent magnetic nanoprobes, methods of making, and methods of use  
Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.
8721858 Non-focusing tracers for indirect detection in electrophoretic displacement techniques  
A novel method for visualizing electrokinetic process zones (e.g., for isotachophoresis (ITP)) is provided. We introduce negligibly small concentrations of a fluorophore that is not focused by...
8721521 Imaging and evaluating embryos, oocytes, and stem cells  
Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or...
US20140130214 MONOLITHIC INTERFEROMETRIC ATOMIC FORCE MICROSCOPY DEVICE  
A fiber-facet AFM probe enabling high-resolution, high sensitivity measurement of a sample surface is presented. AFM probes in accordance with the present invention include an optically resonant...
US20140130213 INTERFEROMETRIC ATOMIC-FORCE MICROSCOPY DEVICE AND METHOD  
A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes...
US20140128935 IMPLANTED CARDIAC DEVICE FOR DEFIBRILLATION  
An implantable medical device for delivering electrical cardiac therapy includes a first implantable housing containing a battery. There is also a second implantable housing separate from the first...
US20140126666 EXPLOITING SPATIAL DEGREES OF FREEDOM IN MULTIPLE INPUT MULTIPLE OUTPUT (MIMO) RADIO SYSTEMS  
Methods and apparatuses, including computer program products, are provided for determining the null-space for a channel between a transmitter and an unintended receiver. In one aspect there is...
8717489 Variable imaging arrangements and methods therefor  
Various approaches to imaging involve selecting directional and spatial resolution. According to an example embodiment, images are computed using an imaging arrangement to facilitate selective...
8716462 Levels and/or sustainability of DNA-based gene expression  
The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to...
8716447 Optically-based stimulation of target cells and modifications thereto  
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule...