Patents and Patent Applications from Stanford University


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US20160115558 CONTROL OF METABOLIC FLUX IN CELL-FREE BIOSYNTHETIC SYSTEMS  
Methods are provided for controlling metabolic flux rate in a cell-free system comprising a complex set of enzymes, to produce a desired product of a pathway of interest. In the methods of the...
US20160115173 METHODS AND COMPOSITIONS FOR STUDYING, IMAGING, AND TREATING PAIN  
Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain,...
US20160114325 FLUORINATED PICKERING EMULSION  
Described here is a composition comprising amphiphilic silica nanoparticles, wherein the silica nanoparticles are partially fluorinated. Also described here is a method for droplet-based assay,...
US20160113489 MODULAR LENS ADAPTERS FOR MOBILE ANTERIOR AND POSTERIOR SEGMENT OPHTHALMOSCOPY  
A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging...
9326366 Intra pulse multi-energy method and apparatus based on RF linac and X-ray source  
The relative position of an RF waveform and electron bunches in a linear accelerator is controlled by appropriate control of the accelerator electronics. Thus the energy given to any particular...
9325432 Systems and methods for full-duplex signal shaping  
The current subject matter relates to a system and a method for processing signals. The system can include a transmitting antenna for transmitting a signal over a plurality of wireless spectrum...
9320832 Electrochemical disinfection of implanted catheters  
An implantable catheter is provided that may be disinfected without removal from the body of a patient, using an electrochemical method to generate an electric field on the catheter surface and...
9320724 Method of improving cognition and increasing dendritic complexity in humans with down syndrome and compositions therefor  
A method of improving cognition in a patient with Down syndrome, which entails administering one or more β2 adrenergic receptor agonists to the patient in an amount and with a frequency effective...
9320478 Dual-isotope position emitting tomography for disease evaluation  
Simultaneous dual-isotope positron emission tomography (PET) is used to improve disease evaluation. Two distinct molecular probes are simultaneously provided to the imaging target. One of the...
US20160109428 MECHANICAL BIOMARKERS FOR OOCYTE AND EMBRYO VIABILITY  
Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo...
US20160108169 EFFICIENT SYNTHESIS OF RIGID LADDER POLYMERS  
A molecule includes at least one moiety represented by: where R1, R2, R3, and R4 are independently selected from hydride group and groups different from hydride group, and X1 and X2 are bridging...
US20160107996 Mitochondrial Aldehyde Dehyrogenase-2 Modulators and Methods of Use Thereof  
The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.
US20160106435 CLOSURE DEVICE AND METHOD  
Apparatus and methods are provided for ligating a hemorrhoidal blood vessel for treatment of hemorrhoids. An exemplary apparatus includes a housing having a distal end insertable into the rectum,...
9316707 System and method of receive sensitivity correction in MR imaging  
A magnetic resonance imaging (MRI) apparatus includes a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver...
9315484 Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof  
The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The...
9314279 Systems and methods for posterior dynamic stabilization of the spine  
Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded...
9314154 System and method for providing analysis of visual function using a mobile device with display  
A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device...
9312398 Energy storage device with large charge separation  
High density energy storage in semiconductor devices is provided. There are two main aspects of the present approach. The first aspect is to provide high density energy storage in semiconductor...
9310352 Biological cell nanocavity probes  
An optical fiber is combined with a photonic crystal structure (PCS) that is optically coupled to the optical fiber. The fiber has an exposed fiber surface, and the PCS is affixed to the optical...
9309556 Direct capture, amplification and sequencing of target DNA using immobilized primers  
Certain embodiments provide a method for capturing a genomic fragment. The method may comprise: obtaining a substrate comprising a first population of surface-bound oligonucleotides and a second...
9309296 Optically-based stimulation of target cells and modifications thereto  
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule...
9309236 PI-kinase inhibitors with broad spectrum anti-infective activity  
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases,...
9308392 Materials and approaches for optical stimulation of the peripheral nervous system  
A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is...
9308209 Identification of stabilizers of multimeric proteins  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are...
9308011 Surgical device and methods  
A system and method for abdominal surgery is disclosed. The system can have one or more end effectors that can be attached to an introducer and/or tray and inserted into the abdomen through a...
US20160097050 DEVICES AND METHODS FOR DISPLAY OF ENCODED PEPTIDES, POLYPEPTIDES, AND PROTEINS ON DNA  
A novel method for displaying proteins and peptides is disclosed in which individual proteins or peptides remain associated with the DNA encoding them. Proteins or peptides can be generated by in...
9304213 X-ray position detector and implementation in a mirror pointing servo system  
An X-ray beam position and stability detector is provided having a first metal blade collinear with a second metal blade, where an edge of the first metal blade is opposite an edge of the second...
9303289 Phased genome sequencing  
The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure...
9301980 Enhancement of osteogenic potential of bone grafts  
The present invention concerns the enhancement of the osteogenic potential of bone graft by ex vivo treatment with a Wnt polypeptide, such as a liposomal Wnt polypeptide.
US20160093884 HIGH CAPACITY PRELITHIATION REAGENTS AND LITHIUM-RICH ANODE MATERIALS  
Described here is a method for making an anode of a rechargeable battery, comprising incorporating a composition comprising LixM into the anode, wherein M is a Group 14 element. Also described...
US20160091491 METHODS FOR DIAGNOSIS OF CELIAC DISEASE  
A diagnostic test for celiac disease is disclosed. In particular, the invention relates to a method of diagnosing celiac disease by detecting activated, gut-bound CD8+ alpha-beta T lymphocytes and...
US20160090624 Phased Genome Sequencing  
The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure...
9297039 Control of chemical reactions using isotachophoresis  
Isotachophoresis (ITP) is exploited to control various aspects of chemical reactions. In a first aspect, at least one of the reactants of a chemical reaction is confined to an ITP zone, but the...
9296792 Ordered flagellin array as an immunostimulant  
Bacterial flagellin protein is modified to improve adjuvant activity.
9296732 Substituted benzamides and their uses  
Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.
9296621 Doping and reduction of nanostructures and thin films through flame annealing  
A sol-flame method includes 1) forming a sol-gel precursor solution of a source of a dopant; 2) coating a nanostructure or a thin film with the sol-gel precursor solution; and 3) subjecting the...
9296174 Composite laminated structures and methods for manufacturing and using the same  
Variously configured sub-laminate modules are provided, which comprise at least a first ply and a second ply, the first ply comprising fibers extending in a first orientation, the second ply...
US20160083474 Methods for Enhancing Anti-Tumor Antibody Therapy  
Methods are provided to enhance the efficacy of antibody therapy directed to tumor cells.
US20160081984 Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin Amyloidosis and Protein-Protein Interactions  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are...
9291367 Subsurface thermal energy storage of heat generated by concentrating solar power  
Techniques for subsurface thermal energy storage of heat generated by concentrating solar power enable smoothing of available energy with respect to daily and/or seasonal variation. Solar thermal...
9290813 Biomarkers for determining an allograft tolerant phenotype  
Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression level of one or more gene in a sample from the subject,...
9289448 Compositions and methods for treating alzheimer's disease and other tauopathies  
Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or...
9289153 Joint and cartilage diagnosis, assessment and modeling  
Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a...
9287598 RF window assembly comprising a ceramic disk disposed within a cylindrical waveguide which is connected to rectangular waveguides through elliptical joints  
A high-power microwave RF window is provided that includes a cylindrical waveguide, where the cylindrical waveguide includes a ceramic disk concentrically housed in a central region of the...
9286686 Assessing the condition of a joint and assessing cartilage loss  
Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a...
9285336 Sensing platform for quantum transduction of chemical information  
A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed....
9284590 Monodisperse random coil proteins and bioconjugates thereof  
The present disclosure provides substantially monodisperse random coil polypeptides, vectors encoding the polypeptides, conjugates containing the polypeptides, methods for their preparation, and...
9284353 Mammalian codon optimized nucleotide sequence that encodes a variant opsin polypeptide derived from Natromonas pharaonis (NpHR)  
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based...
9283289 Self-quenching activatable COX-2-specific multi-modal molecular probes for diagnosis of cancers, inflammation, and immune system disorders  
Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In...
US20160072128 MANGANESE HEXACYANOMANGANATE AS A HIGH-CAPACITY POSITIVE ELECTRODE FOR RECHARGEABLE BATTERIES  
Described here is a rechargeable battery comprising (a) an electrode comprising manganese hexacyanomanganate in contact with (b) an electrolyte comprising sodium and/or potassium ions. Also...