Patents and Patent Applications from Rutgers The State University of NJ


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US20170356034 ASSAYS FOR RESISTANCE TO ECHINOCANDIN-CLASS DRUGS  
Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to...
US20170355956 COMPOSITIONS FOR INCREASING SURVIVAL OF MOTOR NEURON PROTEIN (SMN) LEVELS IN TARGET CELLS AND METHODS OF USE THEREOF FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY  
Compositions for altering splicing activity of the DcpS gene and increasing SMN protein expression in target cells are provided. Also disclosed are methods of use of such compositions for the...
US20170355706 METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER  
The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds,...
9840533 Compositions and methods for altering second messenger signaling  
The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as...
9839634 Antibacterial agents: combination of a rifamycin and a switch region inhibitor  
It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2)...
US20170351973 QUANTIFYING CREATIVITY IN AUDITORY AND VISUAL MEDIUMS  
This present disclosure describes a novel computational method for assessing fee creativity of human-generated and machine-generated creative products, such as paintings, sculptures, poetry,...
US20170344706 SYSTEMS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISORDERS  
Systems and methods for data compression which facilitate the diagnosis and treatment of neurodevelopmental and neurodegenerative disorders. The methods comprise performing the following...
US20170340261 SYSTEM AND METHOD FOR MEASURING PHYSIOLOGICALLY RELEVANT MOTION  
A system for measuring and monitoring physiologically relevant motion of a subject includes at least a motion sensor to measure movement of the subject and produce a series of movement data...
9828400 Iridium pincer complex for alkane dehydrogenation process  
Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex and iridium pincer complexes. In the dehydrogenation reactions, hydrogen that is...
9828310 Catalyst complex and use thereof in alkane oligomerization  
Provided is a Group 9 novel metal catalyst complex further comprising a ketone-containing cocatalyst. The metal catalyst complex is useful in generating olefins from alkanes with great efficiency....
US20170334952 METHODS AND KITS FOR THE DIAGNOSIS OF CANCER THROUGH DETECTION OF HUMAN ENDOGENOUS RETROVIRUS ENV (HERV-WL)  
The present invention relates to methods and kits for diagnosis of cancer in a subject by detecting human endogenous retrovirus env (HERV-WL) polypeptides.
US20170334870 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE  
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through...
US20170333067 TRANSECTION DEVICE  
A transection device including a hollow tubular body extending from a proximal end to a distal end. A plurality of stabilizing members extend from the distal end of the tubular body and define a...
US20170332674 Chlorine Dioxide Gas Releasing Package Label Insert for Enhancing Microbial Safety of Food  
Disclosed herein are chlorine dioxide releasing package label/inserts to be used inside a package or in an outer plastic bag containing several individual packages, the package label/insert...
9822151 Chemically modified graphene  
This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.
9822108 Antimicrobial agents  
The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of...
US20170321258 DETECTION OF DRUG RESISTANT MYCOBAC TUBERCULOSIS  
This invention relates to nucleic acids, reagents and methods for detecting Rifampicin-resistant Mycobacterium tuberculosis in a sample from a subject. In one aspect, the invention provides...
US20170321198 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems...
US20170319612 INHIBITION OF NONSENSE MEDIATED MRNA DECAY BY DRUGS THAT PREVENT HYPUSINATION OF EUKARYOTIC INITIATION FACTOR 5A  
Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is...
US20170319516 NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER  
2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.
9809626 Antibacterial agents: salinamide derivatives  
The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth,...
9808954 Composition of a timber formulation comprising Cu salts and organic cyclic ingredients for the preservation of timber for decks  
This invention relates to a composition, a process for producing a composition, a timber formulation, a process for producing a timber formulation, a construction comprising the timber formulation...
9804167 Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs  
Disclosed is a method for predicting the optimal amounts of radiopharmaceutical and/or chemotherapy agents to administer to a patient, by determining the level of saturation of the therapeutic...
9802971 Alkane dehydrogenation process  
Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex. In the dehydrogenation reactions, hydrogen that is co-formed during the process must...
9796773 Neutralizing antibodies that bind to the HIV-1 Env V2 critical neutralization domain  
This invention features polypeptides, variants thereof, and fragments thereof useful in eliciting an immune response (e.g., neutralizing antibodies) against a broad spectrum of HIV-1 isolates. The...
US20170299596 MTOR KINASE MUTATIONS AND METHODS OF USE THEREOF  
Certain embodiments of the invention provide a method of detecting the presence of a biomarker associated with resistance to an mTOR kinase inhibitor in a subject, comprising determining the...
9789194 Graft copolymer polyelectrolyte complexes for drug delivery  
Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the...
9784914 Waveguide superlattices for high density photonics integrations  
An apparatus and method for transmitting a plurality of light signals is disclosed. The apparatus includes a splitter configured to split an incoming light signal into a plurality of light...
9782495 Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines  
The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M....
9782432 Polymers and methods thereof for wound healing  
Certain embodiments of the invention provide a copolymer having a backbone, wherein the backbone comprises a) one or more units that comprise a group that will yield a biologically active agent...
US20170280729 BACTERIA WITH 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID (ACC) DEAMINASE FOR PROMOTING TURFGRASS GROWTH  
Compositions and methods for enhancing turfgrass quality and resistance to adverse abiotic conditions are disclosed.
9775907 Cochleates made with soy phosphatidylserine  
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred...
US20170273293 Dispensers and Methods of Use Thereof for Dispensing Solid Mosquito Larvicides and Other Materials of Interest  
Dispenser devices suitable for use on unmanned aerial vehicles are described having utility for dispensing solid larvicides to difficult to reach insect habitats.
9770470 Closed system separation of adherent bone marrow stem cells for regenerative medicine applications  
A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with...
9770465 Inherently radiopaque polymeric products for embolotherapy  
Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
9765196 Inorganic ionomers made from minerals  
Inorganic polymers are produced from silicate (—Si—O—) and/or phosphonate (—P—O—) bonds, commonly found in rocks and glass, to create new polymeric materials for rubbers, fibers, and plastics....
9763968 Hydrogel formulation for dermal and ocular delivery  
Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for...
9761493 Thin epitaxial silicon carbide wafer fabrication  
Techniques for fabricating thin epitaxial SiC device wafers are described. A bulk SiC wafer is used to provide a seed layer of a thin layer of SiC for epitaxially growing SiC. The seed layer is...
9758794 HCV E2 construct compositions and methods  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
9757499 Biomaterial and methods of use thereof for the prevention of post-operative adhesions  
Biofunctional films and methods of use thereof for the prevention of post-operative adhesions are disclosed.
9752192 Compositions and methods for diagnosing autism  
Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related...
US20170247747 Polymerase Chain Reaction Primers and Probes for Mycobacterium Tuberculosis  
The present invention relates to novel primers and sloppy molecular beacon and molecular beacon probes for amplifying segments from different genes in Mycobacterium tuberculosis for identifying...
US20170246351 Biocompatible Textile Sleeves to Support and Guide Muscle Regeneration and Methods of Use Thereof  
A biocompatible sleeve designed to encase an assembly of small 3D muscles that have been cultured in vitro. The sleeve is formed from polymer fibers in such a way that pushing the two ends of the...
US20170246128 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE  
The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering...
US20170245505 HERBAL ESSENTIAL OIL FOR BIOMATERIAL PRESERVATION  
Compositions and methods for inhibiting the decomposition of agricultural products are provided. A composition comprises a breathable sachet of cyclodextrin-encapsulated plant essential oils, such...
9746350 Manual manipulation apparatus  
A manual manipulation apparatus including a frame assembly, at least one handle associated with frame assembly, a mounting structure configured for mounting of a computer device relative to the...
9744528 Metallorganocatalysis for asymmetric transformations  
A ligand having the structure or its enantiomer; (I) wherein: each one of Ra, Rb, Rc and Rd is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH2NH; *CH(CH3)NH(C*,R);...
US20170243486 VEHICULAR INFORMATION SYSTEMS AND METHODS  
Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes...
PP28311 Cornus kousa tree designated ‘Rutpink’  
A new Cornus kousa cultivar that is clearly distinguished by its floriferous display of showy, dark-pink floral bracts, attractive dark-green foliage, high level of winter hardiness, and tolerance...
9732378 Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency  
The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the...