Patents and Patent Applications from Rutgers The State University of NJ


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10024800 Gold nanostar substrates for SERS sensing in the femtomolar regime  
The invention relates to Raman spectroscopy-based sensing technique. More particularly, the invention relates to a surface enhanced Raman spectroscopy (SERS) composite and methods of its use and...
10023521 Process and intermediates for preparing poly(anhydride-esters)  
Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of...
10018540 Clearing agent and mounting media for microscopy  
A clearing agent and mounting solution for microscopy is disclosed comprising at least trichloroethanol and/or derivatives thereof, where the refractive index of the solution is greater than or...
10017430 Alkane-alkene coupling via tandem alkane-dehydrogenation/alkene-dimerization catalyzed by pincer iridium catalyst heterogenized on solid supports  
Disclosed herein are processes for tandem alkene dehydrogenation/alkene dimerization using an iridium pincer complex catalyst on a support comprising magnesium silicates (e.g., Florisil®). The...
10016517 Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity  
The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates...
US20180185491 COCHLEATES MADE WITH SOY PHOSPHATIDYLSERINE  
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred...
US20180185355 Method of Treating Dyskinesia  
Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action μ-opioid receptor antagonist/-ϰ-opioid receptor agonists or prodrug thereof to a...
10010619 Bipartite inhibitors of bacterial RNA polymerase  
The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-α-Y (I) wherein X is an moiety that binds to the rifamycin binding site of a...
US20180179225 ANTIMICROBIAL AGENTS  
The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful...
US20180177889 TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES  
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of...
10004682 Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers  
The present invention provides methods for impregnating a porous carrier with an active pharmaceutical ingredient (“AP”), the methods comprising steps: a) dissolving at least one API in a solvent...
US20180171396 IMAGING INDIVIDUAL MRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBES  
A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding...
9999636 Insulin-mimetics as therapeutic adjuncts for bone regeneration  
Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating...
9999596 Controlled release hydrogels  
Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.
US20180167782 Tracking Service Queues Using Single-Point Signal Monitoring  
A method of tracking a service queue using a single-point signal monitor in which at least one customer carries a wireless device may include: receiving a received signal strength from the...
US20180162792 PREPARATION OF ALKYLAROMATIC COMPOUNDS  
Described herein are methods useful for preparing alkylaromatics.
9994893 Compositions and methods for functional quality control for human blood-based gene expression products  
Methods for assessing the integrity of an RNA sample from a given tissue or blood type are disclosed.
9987336 Attenuating or treating sepsis or septic shock  
Methods for attenuating or treating, or reducing the mortality of sepsis or septic shock using an ectonucleotidase such as CD39 or CD73 are provided.
US20180148408 DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS  
A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more...
9985296 Polymer-derived catalysts and methods of use thereof  
Electrocatalytic polyaniline-derived mesoporous carbon nanoparticles and methods of synthesizing and using the same are provided.
US20180142375 GROWTH OF HIGH QUALITY SINGLE CRYSTALLINE THIN FILMS WITH THE USE OF A TEMPORAL SEED LAYER  
A method of making high quality insulating single crystalline In2Se3 films by (1) depositing at least one quintuple layer (QL) of Bi2Se3 on a substrate layer at a temperature below which only the...
9974745 Encochleation methods, cochleates and methods of use  
Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and...
US20180127454 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING  
The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
US20180125894 Closed System Separation of Adherent Bone Marrow Stem Cells for Regenerative Medicine Applications  
A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with...
US20180118777 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING  
The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
US20180116945 Kojic Acid Polymers  
A controlled release system for kojic acid having improved stability has been identified. To minimize degradation, kojic acid was incorporated into a hydrolytically degradable polymer (e.g., a...
US20180116144 CATNIP CULTIVAR 'CR9'  
The invention provides seed and plants of catnip hybrid ‘CR9’. The invention thus relates to the plants, seeds, and tissue cultures of catnip hybrid ‘CR9’, and to methods for producing a catnip...
9950993 Bacterial efflux pump inhibitors  
Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
9950030 Treatment and diagnosis of ocular disease  
This invention concerns compositions and methods of treating or diagnosing ocular disease.
9949488 miRNA169 compositions and methods for the regulation of carbohydrate metabolism and flowering in plants  
Compositions and methods for modulating flowering, sugar metabolism and stress response in plants are provided.
US20180104305 TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISORDERS AND HIV  
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
9945051 Color-encoding and in-situ interrogation of matrix-coupled chemical compounds  
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of...
9943606 Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents  
Dendritic polypeptides useful for the delivery of therapeutic agents into cells are disclosed, together with their methods of preparation. These dendritic polypeptides serve as carriers of drugs,...
9938575 Compositions and methods for high-throughput nucleic acid analysis and quality control  
Methods for improved quality control of nucleic acid containing biological samples utilized in high-throughput situations such as biorepositories engaged in the collection, processing, storage,...
9938325 HIV-1 antigens with discrete conformational forms in the V1/V2 domain and methods of use thereof  
The present invention relates to a novel composition of HIV-1 Env proteins that contain structurally and immunologically distinct VI/V2 domains. Methods of isolating such proteins, and methods of...
9937933 High level platform trapdoor with built in moving slide for railway platform gap bridging  
A trapdoor assembly for use on railcars is provided. The trapdoor assembly is pivotable between an up position and a down position. In the up position, the trapdoor assembly provides access to...
9936358 Systems and methods for detecting driver phone operation using device position and orientation data  
A method for determining the position in a vehicle of a first device in communication with a microprocessor may include receiving, at the microprocessor, a first set of inertial data from at least...
9932323 Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones  
The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions...
9931361 Treatment to promote wound healing  
The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the...
9931348 Vanadium compounds as therapeutic adjuncts for cartilage injury and repair  
A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable...
US20180085738 CATALYST FOR DEHYDROGENATION REACTION OF FORMATE AND HYDROGENATION REACTION OF BICARBONATE AND PREPARATION METHOD THEREOF  
Provided is a method for preparing a catalyst for a dehydrogenation reaction of formate and a hydrogenation reaction of bicarbonate, the method including: adding a silica colloid to a...
US20180085396 INHERENTLY RADIOPAQUE POLYMERIC PRODUCTS FOR EMBOLOTHERAPY  
Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
9926261 Bacterial efflux pump inhibitors  
Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
9919998 Antibacterial agents: Nα-aroyl-N-aryl-phenylalaninamides  
The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use....
9918980 Method of treating dyskinesia  
Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action μ-opioid receptor antagonist/κ-opioid receptor agonists or prodrug thereof to a...
US20180071360 Compositions for the Treatment of Cancer, and Methods for Testing and Using the Same  
The invention relates to pharmaceutical compositions comprising leukotoxin, including methods to treat lymphoma, and methods to diagnose lymphoma. The lymphoma includes lymphoma cells expressing...
9909159 Highly selective nucleic acid amplification primers  
This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA...
9909134 RNA-Seq transcriptome analysis of spirodela dormancy without reproduction and identification of molecular targets useful for improving biomass production for industrial applications  
Compositions and methods are provided for altering carbon partitioning in biomass isolated from Duckweed.
9907832 Method for increasing interferon activity in an individual  
A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely...
9896720 Imaging individual mRNA molecules using multiple singly labeled probes  
A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding...