Patents and Patent Applications from Penn State University


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8183745 High frequency ultrasound transducers  
An example ultrasound device, such as a transducer array, includes a plurality of ultrasound transducers, each ultrasound transducer having a first electrode, a second electrode, a thin...
US20120115144 Detection of Extracellular Tumor-Associated Nucleic Acid in Blood Plasma or Serum  
This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease....
8175712 Homotopic conditioning of the brain stem baroreflex of a subject  
Disclosed are methods for regulating blood pressure in a subject which include administering a first induction stimulus effective to sensitize brainstem baroreflex neurons of a subject for a period...
8173825 Method of making fatty acid ester derivatives  
Fatty acid ester derivatives and a process for their production from unsaturated fatty acids are disclosed. The process comprises: a) reacting an unsaturated fatty acid or an ester thereof having...
US20120108562 THERAPEUTIC COMPOSITIONS AND METHODS  
PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.
US20120106236 TFET BASED 6T SRAM CELL  
Memory devices and methods of operation are provided. A memory device includes first and second cross-coupled inverters and first and second access transistors coupled to an input node of the...
8163976 Compositions and methods relating to transgenic plants and cellulosic ethanol production  
Transgenic lignocellulosic plants are provided according to embodiments of the present invention, the transgenic plants transformed with an expression cassette encoding a protein operably linked to...
8163505 Methods using PBK1 for identifying agents that treat metabolic disorders  
The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a...
8163347 High energy density nanocomposites and related methods of preparation  
Disclosed are metal oxide-polymer composites having a substrate comprising a metal oxide component, an aluminum oxide component, and a metallocene olefin polymerization catalyst component coupled...
8161973 Reversible vasectomy device and method  
A reversible vasectomy device includes a first and a second connector piece for attachment to the severed ends of the vas deferens. Each connector piece has an outer vas deferens attaching end, an...
8158843 Deep desulfurization of hydrocarbon fuels  
The invention relates to processes for reducing the sulfur content in hydrocarbon fuels such as gasoline, diesel fuel and jet fuel. The invention provides a method and materials for producing ultra...
US20120082351 FAST 3D-2D IMAGE REGISTRATION METHOD WITH APPLICATION TO CONTINUOUSLY GUIDED ENDOSCOPY  
Fast and continuous registration between two imaging modalities makes it possible to completely determine the rigid transformation between multiple sources at real-time or near real-time...
8137913 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of...
8136154 Hidden markov model (“HMM”)-based user authentication using keystroke dynamics  
Hidden Markov Models (“HMMs”) are used to analyze keystroke dynamics measurements collected as a user types a predetermined string on a keyboard. A user enrolls by typing the predetermined str...
US20120055217 ELECTRICAL-ASSISTED DOUBLE SIDE INCREMENTAL FORMING AND PROCESSES THEREOF  
A process for forming a sheet metal component using an electric current passing through the component is provided. The process can include providing a double side incremental forming machine, the...
8129116 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of...
US20120048783 ANALOGUE IONIC LIQUIDS FOR THE SEPARATION AND RECOVERY OF HYDROCARBONS FROM PARTICULATE MATTER  
Systems, methods and compositions for the separation and recovery of hydrocarbons from particulate matter are herein disclosed. According to one embodiment, a method includes contacting particulate...
US20120046419 METHODS AND MATERIALS FOR HYDROCARBON RECOVERY  
Crosslinked polyolefins for use in recovering or containing hydrocarbons such as hydrocarbons contained in oil, are disclosed. Advantageously, the crosslinked polyolefins absorb the hydrocarbon to...
8120770 Three-dimensional (3D) hydrodynamic focusing using a microfluidic device  
A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing...
8113069 Aerodynamic sampler for chemical/biological trace detection  
An aerodynamic sampler for sampling particles from a surface or a flowing gas stream is provided. The sampler can include an arcuate-shaped shroud having a first opening and a second opening, the...
US20120025773 METHOD OF CHARGING BATTERY AND BATTERY CHARGING CONTROL SYSTEM  
A controller in a charging control system controls a charger to heat a battery at a low temperature by pulse charging and discharging up to a desired temperature and then moves to a normal charging...
8108152 Method for redesign of microbial production systems  
A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a...
8097370 Dynamically controllable direct oxidation fuel cell systems and methods therefor  
A direct oxidation fuel cell (DOFC) system comprises at least one fuel cell assembly including a cathode and an anode with an electrolyte positioned therebetween; a source of liquid fuel in fluid...
8093487 Removable protective nose cover  
A removable protective nose cover for a submersible structure having a nose section is disclosed. The removable protective nose cover can include a plurality of shell members, each of the shell...
8093212 Methods of treating nerve-related vision disorders by an insulinomimetic agent  
This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes...
US20110318657 SILICON-AIR BATTERIES  
Silicon-oxygen batteries comprising a silicon anode as chemical fuel, an air-cathode for dissociating oxygen, and an electrolyte, and applications using the same are provided. The silicon-batteries...
8086414 Method and system for modeling cellular metabolism  
This invention relates to methods and systems for in silico or bioinformatic modeling of cellular metabolism. The invention includes methods and systems for modeling cellular metabolism of an...
8080240 Parvovirus methods and compositions for killing neoplastic cells  
According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursers, while...
US20110301930 METHOD FOR DETERMINING GENE KNOCKOUTS  
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining...
US20110299326 TFET BASED 4T MEMORY DEVICES  
A four transistor (4T) memory device is provided. The device includes a first cell transistor and a second cell transistor, the first and second cell transistors coupled to each other and defining...
8071132 Unagglomerated core/shell nanocomposite particles  
The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that...
US20110294025 SURFACE-TREATED HYDROCARBON-BASED POLYMER ELECTROLYTE MEMBRANES FOR DIRECT OXIDATION FUEL CELLS  
A proton (H+)-conducting hydrocarbon (HC)-based polymer electrolyte membrane (PEM) having first and second oppositely facing surfaces comprises a HC-based membrane with at least one...
US20110288008 ANTIBACTERIAL AND PLASMID ELIMINATION AGENTS  
Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear...
8064669 Fast 3D-2D image registration system with application to continuously guided endoscopy  
A novel framework for fast and continuous registration between two imaging modalities is disclosed. The approach makes it possible to completely determine the rigid transformation between multiple...
US20110282079 One-step catalytic conversion of biomass-derived carbohydrates to liquid fuels  
The invention relates to a method for manufacture of hydrocarbon fuels and oxygenated hydrocarbon fuels such as alkyl substituted tetrahydrofurans such as 2,5-dimethyltetrahydrofuran,...
US20110280885 CANCER IMMUNOTHERAPY  
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the a...
US20110275073 Method for detecting tumor-associated DNA in blood or blood fractions  
This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically,...
8052960 Netrin-1 as a biomarker of injury and disease  
Detection and diagnosis of injury and/or disease in a subject can be key to preventing irreversible damage and death. Methods of aiding detection and assessment of a disease or condition in a...
8052848 Ultrasonic and microwave methods for enhancing the rate of a chemical reaction and apparatus for such methods  
The invention relates generally to chemical reactions and processes, and in particular to a method for enhancing the rate of a chemical reaction and to apparatus for carrying out the method. The...
8048629 Detection of extracellular tumor-associated nucleic acid in blood plasma or serum  
This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease....
US20110252800 ALUMINIUM COMBUSTION POWER SYSTEM  
An engine that oxidizes aluminum with water to produce electrical and/or mechanical power. The engine can include a fuel made at least partly from aluminum powder that flows like liquid under high...
8034928 Fluorescence assays with improved sensitivity  
Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group...
US20110240151 FLUIDIC DEVICE  
A fluidic device having a first layer with a first layer wicking channel and a second layer extending across the first layer and having a second layer functional wicking channel. The fluidic device...
US20110239322 IN VITRO FLOWERING/SEED SET LEADING TO PARTIAL OR COMPLETE MALE STERILITY IN GRASSES  
The present invention relates to a method of manipulating plant development that allows for partial or complete male sterility in grasses.
US20110236344 Synthetic mimics of mammalian cell surface receptors: method and compositions  
The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug,...
US20110236210 EXPANDABLE IMPELLER PUMP  
An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades...
8027821 Method for determining gene knockouts  
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining...
8025297 Bellows with alternating layers of high and low compliance material for dynamic applications  
A bellows has a generally tubular elongated bellows body. The bellows body is defined by a wall generally enclosing a volume. The wall has a generally cylindrical inner surface and a generally...
US20110229972 COMPOSITIONS AND METHODS FOR MATERIAL TRANSFER INTO CELLS  
Methods for material transfer into a cell are provided according to the present invention which include electroporation of the cell in the presence of the material, such as nucleic acids, and...
US20110228809 METHODS AND APPARATUS FOR ULTRA-SENSITIVE TEMPERATURE DETECTION USING RESONANT DEVICES  
Methods, apparatus, and systems to improve thermal sensitivity of resonant circuits. One aspect utilizes tracking near-resonance complex impedance for a quartz resonator based calorimeter sensor to...