Patents and Patent Applications from Penn State University


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US20180193802 A Method of Magnetically Aligning and Crystallizing Membrane Proteins  
The disclosure describes a method of forming highly ordered membrane protein crystals. The forming process is done in the presence of a magnetic field to exploit the diamagnetic anisotropy of the...
10020115 High temperature dielectric materials, method of manufacture thereof and articles comprising the same  
Disclosed herein is a dielectric composite comprising an organic polymer that has a glass transition temperature greater than or equal to about 250° C.; and a dielectric filler present in an...
10019658 Identifying visual storm signatures from satellite images  
Satellite images from vast historical archives are analyzed to predict severe storms. We extract and summarize important visual storm evidence from satellite image sequences in a way similar to...
10017803 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing...
US20180185549 Nanostructure Surface Coated Medical Implants and Methods of Using the Same  
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a...
US20180185456 Glucose Oxidase Compositions As A Neonate Anticonvulsant  
Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in...
10013477 Accelerated discrete distribution clustering under wasserstein distance  
Computationally efficient accelerated D2-clustering algorithms are disclosed for clustering discrete distributions under the Wasserstein distance with improved scalability. Three first-order...
10010504 Compositions and methods including celecoxib and plumbagin relating to treatment of cancer  
The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and...
US20180180580 BIOCHEMICAL SENSING USING MICROBUBBLES ON A CHIP USING WHISPERING GALLERY MODE RESONANCE  
A sensing and analysis system on a chip for sensing and analyzing chemical or biological analytes includes a chromatography column having an inlet and an outlet formed on the chip for temporal...
US20180177904 RADIO FREQUENCY TREATMENT TO PHYTOSANITIZE WOOD PACKAGING MATERIALS USED IN INTERNATIONAL SHIPPING  
A method for treating wood packaging materials using Radio Frequency heating includes the steps of heating wood packaging materials using RF heating and applying a pressure before the heating or...
US20180172425 HIGH DEFINITION OPTICAL COHERENCE TOMOGRAPHY IMAGING FOR NON-INVASIVE EXAMINATION OF HERITAGE WORKS  
A high-speed, high-definition optical coherence tomography (OCT) imaging system for non-invasive examination of an artwork in a macroscopic scale includes a high-speed, large field-of-view OCT...
US20180168731 INDIVIDUALIZED PREOPERATIVE PLANNING SYSTEM AND METHOD  
An individualized preoperative planning system for fracture fixation constructs provides fracture assessment before automatically performing finite element simulations to generate biomechanics...
US20180168682 Bedside Stereotactic Ultrasound Guidance Device, System and Method  
The present invention provides fixation devices, locking assemblies, and methods for using the same. The fixation devices of the invention are capable of accurate insertion of medical devices by...
10000781 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing...
9999603 Compositions and methods including leelamine and arachidonyl trifluoromethyl ketone relating to treatment of cancer  
The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including...
US20180162910 DE NOVO STRUCTURAL PROTEIN DESIGN FOR MANUFACTURING HIGH STRENGTH MATERIALS  
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites...
9995875 Method and apparatus for producing crystalline cladding and crystalline core optical fibers  
We provide methods and apparatus for preparing crystalline-clad and crystalline core optical fibers with minimal or no breakage by minimizing the influence of thermal stress during a liquid phase...
US20180155239 SWITCHABLE LIQUID REPELLENT AND ACTIVE WATER HARVESTING SURFACE  
A substrate with a switchable surface has been developed that can rapidly switch its surface character such as between two distinct liquid-repellent modes: (1) a superhydrophobic mode and (2) a...
9988313 Process for production of graphene/silicon carbide ceramic composites  
We provide a method for the in situ development of graphene containing silicon carbide (SiC) matrix ceramic composites, and more particularly to the in situ graphene growth within the bulk ceramic...
US20180150719 AUTOMATICALLY COMPUTING EMOTIONS AROUSED FROM IMAGES THROUGH SHAPE MODELING  
Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. Through experimental...
US20180148688 CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS WITH SMALL MOLECULE COCKTAIL  
Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that...
US20180147604 SLIPPERY ROUGH SURFACES  
Substrates having a textured surface that can maintain or improve droplet mobility in both the Cassie and Wenzel states include a textured surface and a conformal lubricant layer thereover. The...
US20180142184 MULTI-SURFACTANT SYSTEMS  
Multi-surfactant systems where two or more surfactant molecules are coupled to control the spatial distribution of polar groups of the combined surfactant molecules are disclosed. The system can...
9976939 3D laser ablation tomography  
A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system...
9974783 Methods and compositions for treatment of epithelial wounds  
The invention relates to treatment of epithelial wounds. In particular, the invention relates to methods and formulations for treating epithelial wounds based on application of an opioid...
9966232 Ultra-high speed anisotropic reactive ion etching  
A system and method for reactive ion etching (RIE) system of a material is provided. The system includes a plasma chamber comprising a plasma source and a gas inlet, a diffusion chamber comprising...
9963751 Compositions and methods for identifying agents to reduce hepatitis B virus covalently closed circular DNA  
Provided are compositions and methods for identifying test agents as candidate for use in reducing hepatitis B virus (HBV). The methods involve a) introducing at least one test agent into...
9962475 Percutaneous heart pump  
Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes...
US20180117083 COMPOSITIONS AND METHODS FOR COMBATING BACTERIAL INFECTIONS BY KILLING PERSISTER CELLS WITH MITOMYCIN C AND/OR CISPLATIN  
The present disclosure provides a method for killing persister cells with mitomycin C and/or cisplatin, or derivatives thereof. Recalcitrant infections are difficult to treat due to persister...
9957567 Methods relating to DENND1A Variant 2 and polycystic ovary syndrome  
Provided are compositions and methods for use in polycystic ovary syndrome diagnosis (PCOS). The method involves a sample from a subject for a DENND1A Variant 2 mRNA or DENND1 A Variant 2 protein...
US20180114895 HIGH TEMPERATURE SENSORS AND TRANSDUCERS  
A high temperature piezoelectric sensor device such as a high temperature accelerometer, force sensor, pressure sensor, temperature sensor, acoustic sensor and/or acoustic transducer for use at...
9951397 Apparatus for electrical-assisted incremental forming and process thereof  
A process and apparatus for forming a sheet metal component using an electric current passing through the component. The process can include providing an incremental forming machine, the machine...
US20180100788 3D LASER ABLATION TOMOGRAPHY AND SPECTROGRAPHIC ANALYSIS  
A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system...
US20180095220 TRANSITION METAL DOPED ZINC SELENIDE OPTICAL FIBERS AND METHODS FOR MAKING THE SAME  
The invention relates to Cr2+:ZnSe core optical fibers and methods of fabricating thereof, including a hybrid physical-chemical vapor deposition reaction. The invention relates also to Cr2+:ZnSe...
9932360 Qualitative and quantitative point-of-care assays  
Disclosed herein are “equipment-free” flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous, hydrophilic media are patterned...
US20180090309 VERTICAL 2D STRUCTURES FOR ADVANCED ELECTRONIC AND OPTOELECTRONIC SYSTEMS  
The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using...
US20180088053 Luminescent Compositions And Applications Thereof  
In one aspect, methods of sensing are described herein. In some embodiments, a method of sensing comprises disposing a fluorophore in a biological environment, wherein the fluorophore comprises a...
9927263 Intrusion detection system for an undersea environment  
An intrusion detection system includes a suspended optical fiber having a neutral buoyancy and an optical time-domain reflectometer connected to the suspended optical fiber at an origin location....
US20180079869 VESICLES FORMED FROM BLOCK COPOLYMERS, AND NOVEL BLOCK COPOLYMERS  
Vesicles formed from a block copolymer comprising at least one (poly)2-C1-3alkyl-2-oxazoline block and at least one polybutadiene block; and membranes comprising such vesicles. Block copolymers...
US20180077892 TARGETED MODIFICATION OF MAIZE ROOTS TO ENHANCE ABIOTIC STRESS TOLERANCE  
The present invention relates to crop breeding. More particularly, the present invention relates to targeted modification of root to enhance abiotic stress tolerance in maize. In one aspect, the...
9923136 High temperature sensors and transducers  
A high temperature piezoelectric sensor device such as a high temperature accelerometer, force sensor, pressure sensor, temperature sensor, acoustic sensor and/or acoustic transducer for use at...
9918966 Anti-cancer compositions and methods  
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject...
9916131 Techniques and devices for performing arithmetic  
A two-operand adder circuit is provided. The two-operand adder circuit may be configured to receive a bit of a second addend, a carry-in bit, and one or more bits encoding a bit of a first addend,...
US20180064347 HANDHELD DEVICE AND MULTIMODAL CONTRAST AGENT FOR EARLY DETECTION OF HUMAN DISEASE  
Systems comprising a combination of the handheld imaging system with a nanoparticle multimodal contrast agent are disclosed. The imaging system exploits the advantages of both near-infrared...
9912045 Antenna apparatus and communication system  
An antenna includes a first body having an array of resonators; a spacer adjacent to the first body, and a second body adjacent to the spacer such that the spacer is between the first and second...
9911541 Supercapacitor  
Embodiments provide a hybrid supercapacitor exhibiting high energy and power densities enabled by a high-performance lithium-alloy anode coupled with a porous carbon cathode in an electrolyte...
US20180062447 SELF-REGULATED RECONFIGURABLE RESONANT VOLTAGE/CURRENT-MODE METHOD AND DEVICE FOR EXTENDED-RANGE INDUCTIVE POWER TRANSMISSION  
A current-based resonant power delivery (CRPD) device and method with multi-cycle switching that enables efficient inductive power transmission at large distances. The proposed CRPD switches the...
US20180056248 MEMBRANE SURFACE ACTIVATION TO ELIMINATE FOULING AND CONCENTRATION POLARIZATION IN WATER PURIFICATION SYSTEMS  
Disclosed herein is a membrane comprising a bonding layer; and an activation layer disposed on the bonding layer and in contact with it; where the activation layer comprises catalyst nanoparticles...
US20180055838 METHODS AND COMPOSITIONS FOR TREATMENT OF DERMAL AND EPIDERMAL WOUNDS  
This disclosure relates to compositions and methods for the treatment of dermal and epidermal wounds. In particular, the disclosure relates to treating dermal and epidermal wounds based on...
9904869 Automatically computing emotions aroused from images through shape modeling  
Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. Through experimental...