Patents and Patent Applications from Penn State University


Match Document Document Title
US20170358090 SYSTEMS AND METHODS FOR DETECTION OF SIGNIFICANT AND ATTRACTIVE COMPONENTS IN DIGITAL IMAGES  
Systems, methods, and computer-readable media for electronically assessing a visual significance of pixels or regions in an electronic image are disclosed. A method includes receiving the...
US20170354707 CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR  
Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via...
9840583 Fluorescent polymers and applications thereof  
In one aspect, block copolymers are described herein. A block copolymer described herein, in some embodiments, comprises a first block comprising a polymer or oligomer formed from the reaction...
9839618 Compositions and methods relating to proliferative diseases  
Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an...
US20170352394 LOW POWER SENSE AMPLIFIER BASED ON PHASE TRANSITION MATERIAL  
A sense amplifier utilizes a phase transition material (PTM) in conjunction with CMOS circuits to provide a precise sensing threshold. The sense amplifier can be used in memory applications to...
US20170350779 Micromachined Bulk Acoustic Wave Resonator Pressure Sensor  
A pressure sensor includes a piezoelectric substrate having a generally planar structure and an anchor location fixing the piezoelectric substrate at the periphery of the planar structure of the...
9837710 Broadband monopole antenna using anisotropic metamaterial coating  
An antenna system is provided that includes an antenna having an elongated conducting segment, such as a metal rod. An anisotropic metamaterial surrounds the elongated conducting segment of the...
9835532 3D laser ablation tomography and spectrographic analysis  
A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system...
9833744 Membrane fouling reduction using chemical micropumps  
Provided are processes of removing particulate fouling from a filtration membrane or for preventing membrane fouling by particulate matter. A process capitalizes on reversal of a naturally...
US20170345155 MEDICAL IMAGE REPORTING SYSTEM AND METHOD  
This invention relates generally to medical imaging and, in particular, to a method and system for automatic lymph node station mapping, automatic path or route report generation. A computer-based...
9830409 Electromagnetic band gap structure and method for enhancing the functionality of electromagnetic band gap structures  
A method for making an electromagnetic band gap structure includes performing a single full wave simulation for the structure using a computer to perform the simulation, extracting a multiple port...
9817908 Systems and methods for news event organization  
Generally discussed herein are systems, apparatuses, and methods for organizing and/or searching news events. In one or more embodiments, a method can include encoding a news event based on named...
9816120 Low sequence bias single-stranded DNA ligation  
The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor...
US20170320964 Modulators of ACYL-COA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof  
Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating...
9810756 Zero- and low-field transport detection system  
A sensing apparatus for detecting and determining the magnitude of a static magnetic field has a first set of coils capable of producing a sweeping, quasi static, magnetic field when driven by a...
9810708 Automated sampling system  
The automated sampling system has a water tight case that encloses a testing instrument. In the preferred embodiment, the testing instrument is a field-portable ion chromatography instrument...
9806164 Controlled synthesis and transfer of large area heterostructures made of bilayer and multilayer transition metal dichalocogenides  
Embodiments are presented herein that provide a TMD system wherein the first layered material is made of heterobilayers or multilayers with semiconducting direct band gaps. The first layered...
9801909 Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C  
The present disclosure provides a method for killing persister cells with mitomycin C and/or cisplatin, or derivatives thereof. Recalcitrant infections are difficult to treat due to persister...
US20170304463 REGENERATING FUNCTIONAL NEURONS FOR TREATMENT OF DISEASE AND INJURY IN THE NERVOUS SYSTEM  
Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive...
US20170303542 SYNERGISTIC BENZOXABOROLE-CONTAINING ANTI-FUNGICIDAL COMPOSITION  
An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are(is) separately controllable by a...
9800094 Low power nanoelectronics  
Disclosed are low power electronic devices configured to exploit the sub-threshold swing, unidirectional tunneling, and low-voltage operation of steep slope-tunnel tunnel field-effect transistors...
US20170296719 PERCUTANEOUS HEART PUMP  
Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes...
9790323 Polymer conductor for lithium-ion batteries  
We report a new class of single-ion electrolyte including pendant lithium perfluoroethyl sulfonates. Embodiments may be based on, for example, aromatic poly(arylene ether)s, polyphenylenes, or...
9790110 Processes and treatment systems for treating high phosphorous containing fluids  
Disclosed herein are processes for treating high-P fluid involving (1) providing a high-P containing stream; (2) chemically treating the high-P stream such that a majority of dissolved P in the...
US20170290965 HEART ASSIST DEVICE WITH EXPANDABLE IMPELLER PUMP  
An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed...
9783678 High density membrane protein membranes  
Embodiments of the invention provide methods for preparing high density membrane protein membranes by slow, controlled removal of detergent from mixtures of detergent, block copolymers and...
9775932 Nanostructure surface coated medical implants and methods of using the same  
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a...
US20170274100 Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells in Vivo  
Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal...
9765121 De novo structural protein design for manufacturing high strength materials  
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites...
US20170263946 CARBON-BASED NANOSTRUCTURE MEMBRANES  
The disclosure features methods for preparing a carbon nanostructure-based membranes, the methods including initiating self-assembly of a plurality of carbon nanostructures by suspending the...
US20170260151 Novel Selenazolidine and Thiazolidine Compounds for Treating Cancer and Other Diseases  
The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a...
9760805 Identifying visual storm signatures from satellite images  
Satellite images from vast historical archives are analyzed to predict severe storms. We extract and summarize important visual storm evidence from satellite image sequences in a way similar to...
9757699 Spatiotemporal control of chemical microenvironment using oscillating microstructures  
Apparatuses and methods for generating a chemical gradient within a flow channel include providing at least one bubble support structure within the flow channel. A bubble support structure helps...
9757021 Global and semi-global registration for image-based bronchoscopy guidance  
Two system-level bronchoscopy guidance solutions are presented. The first incorporates a global-registration algorithm to provide the physician with updated navigational and guidance information...
US20170253648 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2  
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
US20170253646 Functional Peptide Analogs of PEDF  
The invention provides compositions and methods relating to bioactive peptide analogs of PEDF.
US20170252079 BONE REPAIR SYSTEM AND METHOD  
A bone repair system and method for percutaneously fixing a first bone segment to a second bone segment, such as rib bone segments, in a body of a patient include drilling a first hole through the...
US20170250442 Nanofilled Solid Polymer Electrolytes  
Embodiments of the disclosure relate to solid electrolytes comprising nanowhiskers. More particularly, embodiments of the disclosure relate to solid electrolytes comprising PEO6LiX crystalline...
US20170250433 AMMONIA-BASED THERMOELECTROCHEMICAL SYSTEMS AND METHODS  
Thermally regenerative ammonia-based battery systems and methods of their use to produce electricity are provided according to aspects described herein in which ammonia is added into an anolyte to...
9748019 Single phase lead-free cubic pyrochlore bismuth zinc niobate-based dielectric materials and processes for manufacture  
Both single phase lead-free cubic pyrochlore bismuth zinc niobate (BZN)-based dielectric materials with a chemical composition of Bi1.5Zn(0.5+y)Nb(1.5−x)Ta(x)O(6.5+y), with 0≦x<0.23 and 0≦y<0.9...
9744282 Smart tip LVAD inlet cannula  
Embodiments of the invention provide a left ventricular assist device (LVAD) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide...
US20170239373 GENERATING GABAergic NEURONS IN BRAINS  
This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid...
9737075 Synergistic benzoxaborole-containing anti-fungicidal composition  
An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are (is) separately controllable by a...
US20170233819 Method and Therapeutic Use of PIGN and Other Genes or Gene Products That PIGN Interacts With for Prognosis and Treatment of Hematological Neoplasias  
The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan...
US20170232439 SEPARATION OF LOW-ABUNDANCE CELLS FROM FLUID USING SURFACE ACOUSTIC WAVES  
An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided....
9733465 Waveguides for enhanced total internal reflection fluorescence microscopy  
Evanescently-coupled planar waveguides for enhancing total internal reflection fluorescence microscopy are disclosed. The waveguides include multiple thin layers of one or more materials on a...
9733125 Resonator enhanced raman spectroscopy  
Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal...
9730975 Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair  
Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via...
US20170226342 COMPOSITIONS AND METHODS RELATED TO PROTEINS CAPABLE OF REVERSIBLE TRANSITION TO A MELT  
Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (SRT) protein and a plasticizer or a solvent to obtain a mixture of the SRT...
US20170224690 SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY AND TUMOR CELLS AS AN ANTICANCER THERAPY  
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a...