Patents and Patent Applications from Penn State University


Match Document Document Title
US20170290965 HEART ASSIST DEVICE WITH EXPANDABLE IMPELLER PUMP  
An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed...
9783678 High density membrane protein membranes  
Embodiments of the invention provide methods for preparing high density membrane protein membranes by slow, controlled removal of detergent from mixtures of detergent, block copolymers and...
9775932 Nanostructure surface coated medical implants and methods of using the same  
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a...
US20170274100 Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells in Vivo  
Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal...
9765121 De novo structural protein design for manufacturing high strength materials  
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites...
US20170263946 CARBON-BASED NANOSTRUCTURE MEMBRANES  
The disclosure features methods for preparing a carbon nanostructure-based membranes, the methods including initiating self-assembly of a plurality of carbon nanostructures by suspending the...
US20170260151 Novel Selenazolidine and Thiazolidine Compounds for Treating Cancer and Other Diseases  
The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a...
9760805 Identifying visual storm signatures from satellite images  
Satellite images from vast historical archives are analyzed to predict severe storms. We extract and summarize important visual storm evidence from satellite image sequences in a way similar to...
9757699 Spatiotemporal control of chemical microenvironment using oscillating microstructures  
Apparatuses and methods for generating a chemical gradient within a flow channel include providing at least one bubble support structure within the flow channel. A bubble support structure helps...
9757021 Global and semi-global registration for image-based bronchoscopy guidance  
Two system-level bronchoscopy guidance solutions are presented. The first incorporates a global-registration algorithm to provide the physician with updated navigational and guidance information...
US20170253648 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2  
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
US20170253646 Functional Peptide Analogs of PEDF  
The invention provides compositions and methods relating to bioactive peptide analogs of PEDF.
US20170252079 BONE REPAIR SYSTEM AND METHOD  
A bone repair system and method for percutaneously fixing a first bone segment to a second bone segment, such as rib bone segments, in a body of a patient include drilling a first hole through the...
US20170250442 Nanofilled Solid Polymer Electrolytes  
Embodiments of the disclosure relate to solid electrolytes comprising nanowhiskers. More particularly, embodiments of the disclosure relate to solid electrolytes comprising PEO6LiX crystalline...
US20170250433 AMMONIA-BASED THERMOELECTROCHEMICAL SYSTEMS AND METHODS  
Thermally regenerative ammonia-based battery systems and methods of their use to produce electricity are provided according to aspects described herein in which ammonia is added into an anolyte to...
9748019 Single phase lead-free cubic pyrochlore bismuth zinc niobate-based dielectric materials and processes for manufacture  
Both single phase lead-free cubic pyrochlore bismuth zinc niobate (BZN)-based dielectric materials with a chemical composition of Bi1.5Zn(0.5+y)Nb(1.5−x)Ta(x)O(6.5+y), with 0≦x<0.23 and 0≦y<0.9...
9744282 Smart tip LVAD inlet cannula  
Embodiments of the invention provide a left ventricular assist device (LVAD) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide...
US20170239373 GENERATING GABAergic NEURONS IN BRAINS  
This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid...
9737075 Synergistic benzoxaborole-containing anti-fungicidal composition  
An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are (is) separately controllable by a...
US20170233819 Method and Therapeutic Use of PIGN and Other Genes or Gene Products That PIGN Interacts With for Prognosis and Treatment of Hematological Neoplasias  
The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan...
US20170232439 SEPARATION OF LOW-ABUNDANCE CELLS FROM FLUID USING SURFACE ACOUSTIC WAVES  
An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided....
9733465 Waveguides for enhanced total internal reflection fluorescence microscopy  
Evanescently-coupled planar waveguides for enhancing total internal reflection fluorescence microscopy are disclosed. The waveguides include multiple thin layers of one or more materials on a...
9733125 Resonator enhanced raman spectroscopy  
Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal...
9730975 Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair  
Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via...
US20170226342 COMPOSITIONS AND METHODS RELATED TO PROTEINS CAPABLE OF REVERSIBLE TRANSITION TO A MELT  
Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (SRT) protein and a plasticizer or a solvent to obtain a mixture of the SRT...
US20170224690 SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY AND TUMOR CELLS AS AN ANTICANCER THERAPY  
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a...
9727802 Automatic, computer-based detection of triangular compositions in digital photographic images  
An intelligent system detects triangles in digital photographic images, including portrait photography. The method extracts a set of filtered line segments as candidate triangle sides and/or...
US20170217914 Novel Triarylethylene Compounds and Methods Using Same  
The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a...
US20170216477 COMPOSITE MATERIALS  
A composite material is formed by combining an expandable polymer having a charge with another polymer having an opposite charge to produce. In particular, the composite material can be prepared...
9720998 Massive clustering of discrete distributions  
The trend of analyzing big data in artificial intelligence requires more scalable machine learning algorithms, among which clustering is a fundamental and arguably the most widely applied method....
9717833 Heart assist device with expandable impeller pump  
An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed...
9717804 Regenerating functional neurons for treatment of disease and injury in the nervous system  
Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive...
US20170209478 ENCAPSULATION AND HIGH LOADING EFFICIENCY OF PHOSPHORYLATED DRUG AND IMAGING AGENTS IN NANOPARTICLES  
Method of producing nanoparticle of drug and imaging agents are provided. The phosphorylated encapsulated drugs and imaging agents could be encapsulated at therapeutic levels, were encapsulated at...
US20170209438 A Compound For Anti-Cancer Therapy That Acts By Targeting GOF Mutant P53 And Stimulates P73 To Restore The P53 Pathway Signaling  
The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or...
9713662 Smart tip LVAD inlet cannula  
Embodiments of the invention provide a left ventricular assist device (LVAD) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide...
US20170206988 THERMOACOUSTIC ENHANCEMENTS FOR NUCLEAR FUEL RODS AND OTHER HIGH TEMPERATURE APPLICATIONS  
A nuclear thermoacoustic device includes a housing defining an interior chamber and a portion of nuclear fuel disposed in the interior chamber. A stack is disposed in the interior chamber and has...
US20170202998 ANTIMICROBIAL POLYMERS  
In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) an alkoxylated or alkenoxylated citric acid, citrate, or...
9710746 Radio frequency identification antenna apparatus  
Embodiments of an RFID tag antenna apparatus can include a ground plane, a first patch, and a second patch. The first and second patches can be positioned to define a radiating slot that is...
9708411 Modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof  
Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating...
US20170201026 ANTENNA APPARATUS AND COMMUNICATION SYSTEM  
An antenna includes a first body having a ring monopole and a second body positioned below the first body. The second body can have a plurality of notched ring resonators. A spacer can be...
9688895 Methods and materials for hydrocarbon recovery  
Crosslinked polyolefins for use in recovering or containing hydrocarbons such as hydrocarbons contained in oil, are disclosed. Advantageously, the crosslinked polyolefins absorb the hydrocarbon to...
9688152 Hybrid power and energy for robots  
Advances in robot performance have been limited by a lack of advances in the mature field of battery technology. The focus of robotic power systems must expand from the use of single energy...
US20170179853 ENERGY HARVESTING DEVICE USING ELECTROACTIVE POLYMER NANOCOMPOSITES  
An energy harvesting device includes: a first nanoporous electrode and a second nanoporous electrode, each of which is configured to which store electrical charge; a first current collector...
US20170175258 Facile Route to Templated Growth of Two-Dimensional Layered Materials  
The present invention relates to methods for fabricating a laterally-limited two-dimensional structure through template synthesis. The methods of the invention are useful in forming homogenous and...
US20170175086 PARAMYXOVIRUS VIRUS-LIKE PARTICLES AS PROTEIN DELIVERY VEHICLES  
Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety...
RE46445 NBT based lead-free piezoelectric materials for high power applications  
Piezoelectric compounds of the formula xNamBinTiO3-yKmBinTiO3-zLimBinTiO3-pBaTiO3 where (0
9685577 Light emitting diodes and photodetectors  
The present application relates generally to light emitting diodes and photodetectors as well as their methods of manufacture and use. In one exemplary embodiment, an integrated device may include...
9683514 High efficiency combustor and closed-cycle heat engine interface  
A powering system includes an engine having a first side and an interface for providing heat to the first side of the engine. The interface includes a combustor having a combustion chamber...
US20170166952 Polymer-Based Signal Amplification for Protein and Cell Detection  
The present invention relates generally to compositions, methods and kits for detection of a molecule of interest. The present invention is based, at least in part, on the design of nucleic acid...
9676844 Pharmaceutical compositions comprising DENND1A variant 2 and methods of use thereof  
Pharmaceutical compositions and methods for the treatment of DENND1 A. V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...