Patents and Patent Applications from Oregon Health and Science University


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US20170350887 CMV GLYCOPROTEINS AND RECOMBINANT VECTORS  
This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues...
US20170348433 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES  
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human...
US20170333009 INSTRUMENTS USED IN COLLECTING FLUID SAMPLES  
Disclosed are instruments used in collecting fluid samples from a subject such as, for example, aqueous humor samples. The instrument involves a linear actuator that, when engaged by the user via...
US20170332929 Method and System to Access Inapparent Conduction Abnormalities to Identify Risk of Ventricular Tachycardia  
A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to...
9820998 Use of bisphosphonates as HIV/AIDS adjunctive treatment  
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an...
US20170319060 SYSTEMS AND METHODS TO COMPENSATE FOR REFLECTANCE VARIATION IN OCT ANGIOGRAPHY  
Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to...
9808485 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
9805145 Composite simulation modeling and analysis  
An aspect of combining simulation models includes a processor configured to process information relating to a plurality of simulated models. The processor collects the information to be processed...
9805143 Composite simulation modeling and analysis  
An aspect of handling a plurality of simulated models includes receiving from a first simulation model a stream of source data and determining data processing compatibility between the simulation...
US20170307610 COMPOUNDS THAT BIND DYSTROGLYCAN AND USES THEREOF  
Disclosed herein are methods and compositions involved in identifying cells that lack apico-basal polarity as well as methods and compositions involved in selectively delivering payload molecules...
US20170298042 VMAT INHIBITORY COMPOUNDS  
Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and...
9790509 5′-triphosphate oligoribonucleotides  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20170290526 TELECENTIVE SPIROMETER  
Systems and methods to encourage a patient to use an incentive spirometer (IS) device according to the schedule prescribed by a clinician are described. The systems and methods for a...
9783823 Cytomegalovirus vectors enabling control of T cell targeting  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
9776349 System for controlling the closing speed of valve gated nozzles  
Systems and methods for controlling the closing speed of valve gated nozzles are disclosed. In one embodiment, a hot runner have a valve gated nozzle including a valve stem movable between an open...
US20170268007 5'-TRIPHOSPHATE OLIGORIBONUCLEOTIDES  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20170262984 Methods, Systems, and Apparatuses for Quantitative Analysis of Heterogeneous Biomarker Distribution  
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of...
9759725 Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins  
The present disclosure provides methods for determining the effectiveness of a cancer therapy, as well as methods for increasing the effectiveness of that therapy and determining a prognosis for a...
US20170253879 APTAMER-RNAi THERAPEUTIC COMPOSITIONS  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORγ2 is described herein. Pharmaceutical compositions comprising the...
9751897 Derivatives of Bodipy  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170233444 RTEF-1 VARIANTS AND USES THEREOF  
Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1...
US20170233414 DERIVATIVES OF BODIPY  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170231560 SYSTEMS AND APPARATUS FOR MEASURING A BIOACTIVE AGENT EFFECT  
Apparatus and systems are described that include physical media related to accepting at least one attribute associated with an individual from a licensed health care provider and/or presenting an...
9734834 Comfort noise generation  
A system for generating comfort noise for a stream of frames carrying an audio signal includes frame characterizing logic configured to generate a set of filter parameters characterising the...
US20170226182 PD-1 MODULATION AND USES THEREOF FOR MODULATING HIV REPLICATION  
Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs...
US20170220850 SYSTEM FOR INTERPRETATION OF IMAGE PATTERNS IN TERMS OF ANATOMICAL OR CURATED PATTERNS  
Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it...
9720792 Information theoretic caching for dynamic problem generation in constraint solving  
Computer-implemented techniques are disclosed for verifying circuit designs using dynamic problem generation. A device under test (DUT) is modeled as part of a test bench where the test bench is a...
9717782 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
US20170209687 DEEP BRAIN ELECTRODE PLACEMENT AND STIMULATION BASED ON BROWN ADIPOSE TISSUE TEMPERATURE  
Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a...
9715368 Computerized information and display apparatus with rapid convergence algorithm  
A computerized information and display apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, touch screen input and...
US20170204195 ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF  
Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an...
9710225 Computerized information and display apparatus with automatic context determination  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and speech input apparatus, touch...
9709972 Computerized information and display apparatus with remote environment control  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and first wireless interface, radio...
US20170196957 RECOMBINANT T CELL RECEPTOR LIGAND COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CANCER  
Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the...
9701650 Derivatives of sobetirome  
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
US20170188930 ANIMATION-BASED AUTISM SPECTRUM DISORDER ASSESSMENT  
Systems and methods for quantitative assessment of autism spectrum disorder based on detected responses of a subject to displayed animations are disclosed. In one example approach, a method for...
9699119 Determining transmission rates when transmitting parallel data streams from a wireless station of a wireless network  
A wireless station (STA) of a wireless network transmits parallel data streams. The STA maintains transmission profiles, each corresponding to a respective data stream of parallel data streams. A...
9695410 Isolated high affinity entities with T-cell receptor like specificity towards native complexes of MHC class II and glutamic acid decarboxylase (GAD) autoantigenic peptides  
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural...
US20170182089 ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND  
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury...
US20170173169 CROSS-LINKED POLYMER MODIFIED NANOPARTICLES  
Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small...
9683239 Aptamer-RNAi therapeutic compositions  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORγ2 is described herein. Pharmaceutical compositions comprising the...
US20170169590 SYSTEMS AND METHODS TO REMOVE SHADOWGRAPHIC FLOW PROJECTIONS IN OCT ANGIOGRAPHY  
Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is...
US20170169565 OPTICAL COHERENCE TOMOGRAPHY GLAUCOMA DETECTION BASED ON RETINAL VESSEL RELIEF HEIGHT  
Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach,...
9677088 Adeno associated virus plasmids and vectors  
Disclosed herein are adeno associated viral plasmids and viral vectors. Also disclosed are methods of using adeno associated viral vectors.
US20170160171 MULTIPLEX IMMUNOHISTOCHEMISTRY IMAGE CYTOMETRY  
Immunohistochemical (IHC) techniques that enable the sequential evaluation of at least seven biomarkers in one formalin-fixed paraffin-embedded (FFPE) tissue section are disclosed. The methods...
US20170152476 HUMAN PLURIPOTENT STEM CELLS PRODUCED BY SOMATIC CELL NUCLEAR TRANSFER  
Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.
US20170146519 STING AGONISTS AND METHODS OF SELECTING STING AGONISTS  
Disclosed are small molecules capable of activating the type I interferon (IFN) response by way of the transcription factor IFN regulatory factor 3 (IRF3) were identified. A high throughput in...
US20170146517 COMPOUNDS AND METHODS USED IN ASSESSING MONO-PARP ACTIVITY  
Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify...
US20170145517 METHODS OF DETECTING CANCERS SENSITIVE TO CABOZANTINIB  
The emergence of resistance to targeted therapy is a recurrent clinical challenge and requires development and validation of secondary agents with improved activity. Accompanied by experimental...
US20170144974 ACRIDONE COMPOUNDS  
A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat...