Patents and Patent Applications from Oregon Health and Science University


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US20170290526 TELECENTIVE SPIROMETER  
Systems and methods to encourage a patient to use an incentive spirometer (IS) device according to the schedule prescribed by a clinician are described. The systems and methods for a...
9783823 Cytomegalovirus vectors enabling control of T cell targeting  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
9776349 System for controlling the closing speed of valve gated nozzles  
Systems and methods for controlling the closing speed of valve gated nozzles are disclosed. In one embodiment, a hot runner have a valve gated nozzle including a valve stem movable between an open...
US20170268007 5'-TRIPHOSPHATE OLIGORIBONUCLEOTIDES  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20170262984 Methods, Systems, and Apparatuses for Quantitative Analysis of Heterogeneous Biomarker Distribution  
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of...
9759725 Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins  
The present disclosure provides methods for determining the effectiveness of a cancer therapy, as well as methods for increasing the effectiveness of that therapy and determining a prognosis for a...
US20170253879 APTAMER-RNAi THERAPEUTIC COMPOSITIONS  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORĪ³2 is described herein. Pharmaceutical compositions comprising the...
9751897 Derivatives of Bodipy  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170233444 RTEF-1 VARIANTS AND USES THEREOF  
Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1...
US20170233414 DERIVATIVES OF BODIPY  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170231560 SYSTEMS AND APPARATUS FOR MEASURING A BIOACTIVE AGENT EFFECT  
Apparatus and systems are described that include physical media related to accepting at least one attribute associated with an individual from a licensed health care provider and/or presenting an...
9734834 Comfort noise generation  
A system for generating comfort noise for a stream of frames carrying an audio signal includes frame characterizing logic configured to generate a set of filter parameters characterising the...
US20170226182 PD-1 MODULATION AND USES THEREOF FOR MODULATING HIV REPLICATION  
Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs...
US20170220850 SYSTEM FOR INTERPRETATION OF IMAGE PATTERNS IN TERMS OF ANATOMICAL OR CURATED PATTERNS  
Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it...
9720792 Information theoretic caching for dynamic problem generation in constraint solving  
Computer-implemented techniques are disclosed for verifying circuit designs using dynamic problem generation. A device under test (DUT) is modeled as part of a test bench where the test bench is a...
9717782 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
US20170209687 DEEP BRAIN ELECTRODE PLACEMENT AND STIMULATION BASED ON BROWN ADIPOSE TISSUE TEMPERATURE  
Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a...
9715368 Computerized information and display apparatus with rapid convergence algorithm  
A computerized information and display apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, touch screen input and...
US20170204195 ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF  
Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an...
9710225 Computerized information and display apparatus with automatic context determination  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and speech input apparatus, touch...
9709972 Computerized information and display apparatus with remote environment control  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and first wireless interface, radio...
US20170196957 RECOMBINANT T CELL RECEPTOR LIGAND COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CANCER  
Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the...
9701650 Derivatives of sobetirome  
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
US20170188930 ANIMATION-BASED AUTISM SPECTRUM DISORDER ASSESSMENT  
Systems and methods for quantitative assessment of autism spectrum disorder based on detected responses of a subject to displayed animations are disclosed. In one example approach, a method for...
9699119 Determining transmission rates when transmitting parallel data streams from a wireless station of a wireless network  
A wireless station (STA) of a wireless network transmits parallel data streams. The STA maintains transmission profiles, each corresponding to a respective data stream of parallel data streams. A...
9695410 Isolated high affinity entities with T-cell receptor like specificity towards native complexes of MHC class II and glutamic acid decarboxylase (GAD) autoantigenic peptides  
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural...
US20170182089 ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND  
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury...
US20170173169 CROSS-LINKED POLYMER MODIFIED NANOPARTICLES  
Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small...
9683239 Aptamer-RNAi therapeutic compositions  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORĪ³2 is described herein. Pharmaceutical compositions comprising the...
US20170169590 SYSTEMS AND METHODS TO REMOVE SHADOWGRAPHIC FLOW PROJECTIONS IN OCT ANGIOGRAPHY  
Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is...
US20170169565 OPTICAL COHERENCE TOMOGRAPHY GLAUCOMA DETECTION BASED ON RETINAL VESSEL RELIEF HEIGHT  
Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach,...
9677088 Adeno associated virus plasmids and vectors  
Disclosed herein are adeno associated viral plasmids and viral vectors. Also disclosed are methods of using adeno associated viral vectors.
US20170160171 MULTIPLEX IMMUNOHISTOCHEMISTRY IMAGE CYTOMETRY  
Immunohistochemical (IHC) techniques that enable the sequential evaluation of at least seven biomarkers in one formalin-fixed paraffin-embedded (FFPE) tissue section are disclosed. The methods...
US20170152476 HUMAN PLURIPOTENT STEM CELLS PRODUCED BY SOMATIC CELL NUCLEAR TRANSFER  
Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.
US20170146519 STING AGONISTS AND METHODS OF SELECTING STING AGONISTS  
Disclosed are small molecules capable of activating the type I interferon (IFN) response by way of the transcription factor IFN regulatory factor 3 (IRF3) were identified. A high throughput in...
US20170146517 COMPOUNDS AND METHODS USED IN ASSESSING MONO-PARP ACTIVITY  
Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify...
US20170145517 METHODS OF DETECTING CANCERS SENSITIVE TO CABOZANTINIB  
The emergence of resistance to targeted therapy is a recurrent clinical challenge and requires development and validation of secondary agents with improved activity. Accompanied by experimental...
US20170144974 ACRIDONE COMPOUNDS  
A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat...
US20170143817 DENGUE VIRUS VACCINE  
Recombinant fusion proteins including a dengue virus EIII and an E2 subunit derived from a thermophilic bacterium are described. Also described are expression vectors including a polynucleotide...
US20170143809 CMV VECTORS COMPRISING MICRORNA RECOGNITION ELEMENTS  
Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid...
9650426 RTEF-1 variants and uses thereof  
Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1...
US20170119242 SYSTEMS AND METHODS FOR RETINAL LAYER SEGMENTATION IN OCT IMAGING AND OCT ANGIOGRAPHY  
Disclosed herein are methods and systems for segmenting, visualizing, and quantifying the layered structure of retina in optical coherence tomography datasets. The disclosed methods have...
9637550 Anti-fXI antibodies and methods of use  
Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of...
9636399 Anti-factor XI monoclonal antibodies and methods of use thereof  
Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an...
US20170114117 COMPOUNDS THAT BIND MACROPHAGE MIGRATION INHIBITORY FACTOR  
Recombinant polypeptides, pharmaceutical compositions comprising recombinant polypeptides, and methods of treating autoimmune and/or inflammatory diseases using the pharmaceutical compositions are...
9631180 Recombinant manganese oxidase  
Disclosed herein is a recombinant Bacillus manganese oxidase complex, including a bacterial expression vector for the expression of the complex and a method of synthesizing the complex.
US20170108232 HIGH EFFICIENCY SCALABLE STRUCTURE  
A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that...
US20170106101 METHODS INVOLVING MACROPHAGE TUMOR CELL FUSION HYBRIDS  
Methods of identifying circulating macrophage-tumor cell fusion hybrids from a subject, methods of screening test compounds for inhibition of activity of in vitro and in vivo derived...
US20170105395 NORMALIZATION OF THE ENTEROHEPATIC CIRCULATION IN ANIMALS WITH A CHIMERIC HUMANIZED LIVER  
Methods of normalizing bile acid production in a mouse engrafted with human hepatocytes by the administration of human FGF19 are disclosed. Also disclosed is a transgenic host animal, such as a...
9619875 Contrast reagent leakage correction in dynamic susceptibility contrast magnetic resonance imaging  
Disclosed are methods and systems for calculating a contrast reagent (CR) extravasation rate constant and generating a contrast reagent leakage corrected relative cerebral blood volume (rCBV)...