Patents and Patent Applications from Oregon Health and Science University


Match Document Document Title
10473667 Methods apparatuses and systems for detecting and quantifying phosphoproteins  
Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and...
US20190330632 COMPOSITIONS AND METHODS USED IN DIAGNOSING AND TREATING COLORECTAL CANCER  
Disclosed are methods of treating colorectal cancer that involve administering a composition comprising an effective amount of miR-451a to cells in the colorectal cancer and further treating the...
10457682 Small molecules that bind MR1  
Disclosed are small molecules and pharmaceutical compositions comprising them that can be used in treating diseases associated with the major histocompatibility complex (MHC) molecule MR1.
US20190309264 Three Dimensional Bioprinted Tumor Models for Drug Testing  
Described are three-dimensional, engineered, biological cancer models, methods of producing the same, and methods of identifying a therapeutic agent for cancer in an individual utilizing the...
US20190300883 MICRORNA INHIBITORS AS ANTI-CANCER THERAPEUTICS  
MicroRNA inhibitors as anti-cancer therapeutics are described. The microRNA inhibitors can inhibit microRNA-15a and can mimic the effects of higher dose radiation at lower doses. Other benefits...
10428118 Human cytomegalovirus comprising exogenous antigens  
Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes,...
10426331 Automated quantification of nonperfusion in the retina using optical coherence tomography angiography  
Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of...
US20190292545 5'-TRIPHOSPHATE OLIGORIBONUCLEOTIDES  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20190292519 GENERATION OF HUMAN OOCYTES  
Methods are provided of generating functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT)...
US20190292136 Tert-AMINE CORE-BEARING ACYRLAMIDES AND ADHESIVE FORMULATIONS  
The present invention provides tertiary amine core-bearing acrylamides and their use in adhesive formulations, particularly including dental adhesives.
US20190290717 COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY  
A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of...
US20190285291 HIGH EFFICIENCY SCALABLE STRUCTURE  
A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that...
US20190276845 NON-TOXIC HSV VECTORS FOR EFFICIENT GENE DELIVERY APPLICATIONS AND COMPLEMENTING CELLS FOR THEIR PRODUCTION  
In one embodiment, the invention provides a herpes simplex virus (HSV) vector that does not express toxic HSV genes in non-complementing cells and which comprises a genome comprising one or more...
US20190274928 ENTERAL FEEDING TUBE HOUSING AND FIXATION DEVICES  
Enteric feeding tube housings configured to secure a feeding tube to the body are disclosed. The housing includes a disc having a hole configured to accommodate the feeding tube and two or more...
US20190271592 MULTISPECTRUM SUPER RESOLUTION MICROSCOPY  
Devices, systems, reagents, and methods for the performance of multi-spectrum super resolution microscopy are disclosed.
10398772 Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy  
Compositions including a therapeutically effective amount of an HIV immunogen in combination with an agent that stimulates the Ras pathway, wherein the agent is not an aluminum salt, are...
10392649 Biosensors that detect NAD+  
A polypeptide biosensor that detects free NAD+ is disclosed. The polypeptide comprises a first fragment from an NAD+ dependent DNA ligase acetylation domain, a second fragment from the NAD+...
10392356 Derivatives of sobetirome  
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
US20190255079 COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES CHARACTERIZED BY INSUFFICIENT PANTOTHENATE KINASE ACTIVITY  
Methods and pharmaceutical compositions for use in treating diseases associated with insufficient activity of the pantothenate kinase enzyme (e.g., CASTOR diseases) are disclosed. The methods and...
US20190254533 SYSTEMS AND METHODS FOR TRACKING NEURO-DEVELOPMENT DISORDERS  
A system captures a baby's physical characteristics taken on two or more specified days since birth and sensor input from a device capturing a rhythm produced by the baby's nervous system on at...
US20190240025 Methods for creating sinus-matched aortic valves  
Methods for generating aortic heart valve leaflets are disclosed wherein the aortic sinus surfaces (the inner surfaces of the sinuses of Valsalva) are used as a template to generate geometric...
10363421 Electrode placement and stimulation based on brown adipose tissue temperature  
Systems and methods for spinal cord electrode placement and spinal cord stimulation their use for treatment of conditions such as obesity are disclosed. In one example approach, during placement...
US20190211356 CMV GLYCOPROTEINS AND RECOMBINANT VECTORS  
Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of...
US20190210950 DERIVATIVES OF SOBETIROME  
Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and...
10342745 Methacrylamide compounds  
New methacrylate compounds are disclosed as well as compositions comprising the methacrylate compounds and thiourethane oligomers. These compositions can be used in, for example, dental composites.
10335048 High-resolution metabolic neuroimaging  
Provided herein are methods and apparatuses for determining a level of cellular metabolic activity for a region of interest in order to detect and map on-going gliovascular unit metabolic activity...
US20190194348 TREATMENT OF THERAPY-RESISTANT HER-2 POSITIVE BREAST CANCER  
This invention concerns the treatment of HER-2 positive breast cancer cells by mediating the signal of GRB7 using an anti-HER-1 antibody, such as panitumumab.
US20190192125 DEVICE FOR ANATOMICAL SENSING SYSTEM-GUIDED ENDORECTAL PROSTATE BIOPSY  
An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, a mid...
US20190192060 DEVICE AND METHOD FOR BLOOD VOLUME MEASUREMENT  
Disclosed are a method, device and system for determining total circulating blood volume (BV) using a minimally invasive technique.
10327635 Systems and methods to compensate for reflectance variation in OCT angiography  
Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to...
10327631 Post-processing reduction of fixed pattern artifacts and trigger jitter in swept-source optical coherence tomography  
Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information...
US20190175721 SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA)...
US20190175531 SOBETIROME IN THE TREATMENT OF MYELINATION DISEASES  
Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath...
10316334 Cytomegalovirus vectors enabling control of T cell targeting  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
10316075 Recombinant polypeptides comprising MHC class II α1 domains  
Recombinant polypeptides comprising a DRα1 domain, an antigenic peptide, and a linker sequence are disclosed. The linker sequence comprises a first glycine-serine spacer, a thrombin cleavage site...
US20190167100 SYSTEMS AND METHODS TO REMOVE SHADOWGRAPHIC FLOW PROJECTIONS ON OCT ANGIOGRAPHY  
Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is...
10299887 Atmospheric non-thermal gas plasma method for dental surface treatment  
The provision of dental restorations can be improved by generating a cold atmospheric plasma inside the mouth of the patient and then applying that cold atmospheric plasma onto a dental...
US20190153539 EVALUATION OF MANTLE CELL LYMPHOMA AND METHODS RELATED THERETO  
The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the...
US20190150729 SYSTEMS AND METHODS FOR AUTOMATED WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at...
10297262 Comfort noise generation  
A system for generating comfort noise for a stream of frames carrying an audio signal includes frame characterizing logic configured to generate a set of filter parameters characterising the...
US20190142835 INHIBITION OF AUTOPHAGY USING PHOSPHOLIPASE A2 INHIBITORS  
Provided are methods and pharmaceutical combinations utilizing a phospholipase A2 inhibitor for the inhibition of treatment-induced autophagy.
10285580 Video endoscope  
A video endoscope comprises a shaft comprising a rigid, proximal-side section and a distal section that is laterally deflectable in a plane from the central longitudinal axis of the shaft. A...
US20190135871 RECOMBINANT ADENO-ASSOCIATED VIRAL VECTORS  
Disclosed are adeno-associated viral vectors and plasmids encoding the same. Also disclosed are methods of using adeno-associated viral vectors to deliver a protein of interest to the subject. The...
US20190134235 18F-FNDP FOR PET IMAGING OF SOLUBLE EPOXIDE HYDROLASE (sEH)  
Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed.
US20190111126 SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA  
The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that....
US20190106495 METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS  
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the β2-microglobulin (B2M) level in the mammal in a manner sufficient...
10251550 Systems and methods for automated segmentation of retinal fluid in optical coherence tomography  
Disclosed herein are methods and systems for the identification and characterization of fluid accumulation in the retina using OCT imaging. The disclosed methods and systems are directed to the...
US20190099479 RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF  
The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor...
US20190085315 METHODS FOR ENHANCING THE EFFICIENCY OF GENE EDITING  
The present invention provides methods of increasing the efficiency of genome editing.
10231619 Systems and methods to remove shadowgraphic flow projections in OCT angiography  
Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is...