Patents and Patent Applications from Oregon Health and Science University


Match Document Document Title
9883866 Clips and applicator for tissue closure  
Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a...
9883810 In vivo optical flow imaging  
Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split...
9881520 Virtual tool manipulation system  
In the field of virtual reality, virtual tool manipulation systems and related methods and software are described in the present disclosure. One implementation of a virtual tool manipulation...
9879020 GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma  
Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target...
US20180025495 SYSTEMS AND METHODS OF CHOROIDAL NEOVASCULARIZATION DETECTION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection...
US20180023119 SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF  
Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic...
US20180020909 AUTOMATED QUANTIFICATION OF NONPERFUSION IN THE RETINA USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of...
US20180016599 Recombinant Cytomegalovirus Vectors As Vaccines For Tuberculosis  
The present disclosure provides cytomegalovirus vectors encoding fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, cytomegalovirus...
US20180009760 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES  
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and...
9862972 CMV glycoproteins and recombinant vectors  
Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of...
9861517 Vessel closure member, delivery apparatus, and method of inserting the member  
An apparatus which includes a closure member and delivery systems for closing vessels in the body of a patient is disclosed. In one embodiment, the closure member is a hemostatic closure member...
US20180000342 DIAGNOSTIC CLASSIFICATION OF CORNEAL SHAPE ABNORMALITIES  
Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which...
US20170369577 RECOMBINANT CD74 POLYPEPTIDES  
Disclosed are recombinant CD74 polypeptides mutated relative to the naturally occurring CD74 polypeptides with improved properties such as binding of CD74 ligands such as MIF and RTL1000 as well...
US20170368164 SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA)...
US20170362590 PHARMACEUTICAL COMPOSITIONS COMPRISING MICRORNA  
Pharmaceutical compositions comprising one or more of miR-494-3p, miR-99b-5p, and/or miR-21-3p and a pharmaceutically acceptable carrier as well as methods of using said compositions to treat...
US20170360962 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES  
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human...
9839678 Human tissue kallikrein 1 glycosylation isoforms  
Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical...
US20170350887 CMV GLYCOPROTEINS AND RECOMBINANT VECTORS  
This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues...
US20170348433 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES  
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human...
US20170333009 INSTRUMENTS USED IN COLLECTING FLUID SAMPLES  
Disclosed are instruments used in collecting fluid samples from a subject such as, for example, aqueous humor samples. The instrument involves a linear actuator that, when engaged by the user via...
US20170332929 Method and System to Access Inapparent Conduction Abnormalities to Identify Risk of Ventricular Tachycardia  
A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to...
9820998 Use of bisphosphonates as HIV/AIDS adjunctive treatment  
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an...
US20170319060 SYSTEMS AND METHODS TO COMPENSATE FOR REFLECTANCE VARIATION IN OCT ANGIOGRAPHY  
Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to...
9808485 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
9805145 Composite simulation modeling and analysis  
An aspect of combining simulation models includes a processor configured to process information relating to a plurality of simulated models. The processor collects the information to be processed...
9805143 Composite simulation modeling and analysis  
An aspect of handling a plurality of simulated models includes receiving from a first simulation model a stream of source data and determining data processing compatibility between the simulation...
US20170307610 COMPOUNDS THAT BIND DYSTROGLYCAN AND USES THEREOF  
Disclosed herein are methods and compositions involved in identifying cells that lack apico-basal polarity as well as methods and compositions involved in selectively delivering payload molecules...
US20170298042 VMAT INHIBITORY COMPOUNDS  
Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and...
9790509 5′-triphosphate oligoribonucleotides  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20170290526 TELECENTIVE SPIROMETER  
Systems and methods to encourage a patient to use an incentive spirometer (IS) device according to the schedule prescribed by a clinician are described. The systems and methods for a...
9783823 Cytomegalovirus vectors enabling control of T cell targeting  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
9776349 System for controlling the closing speed of valve gated nozzles  
Systems and methods for controlling the closing speed of valve gated nozzles are disclosed. In one embodiment, a hot runner have a valve gated nozzle including a valve stem movable between an open...
US20170268007 5'-TRIPHOSPHATE OLIGORIBONUCLEOTIDES  
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments....
US20170262984 Methods, Systems, and Apparatuses for Quantitative Analysis of Heterogeneous Biomarker Distribution  
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of...
9759725 Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins  
The present disclosure provides methods for determining the effectiveness of a cancer therapy, as well as methods for increasing the effectiveness of that therapy and determining a prognosis for a...
US20170253879 APTAMER-RNAi THERAPEUTIC COMPOSITIONS  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORγ2 is described herein. Pharmaceutical compositions comprising the...
9751897 Derivatives of Bodipy  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170233444 RTEF-1 VARIANTS AND USES THEREOF  
Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1...
US20170233414 DERIVATIVES OF BODIPY  
Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
US20170231560 SYSTEMS AND APPARATUS FOR MEASURING A BIOACTIVE AGENT EFFECT  
Apparatus and systems are described that include physical media related to accepting at least one attribute associated with an individual from a licensed health care provider and/or presenting an...
9734834 Comfort noise generation  
A system for generating comfort noise for a stream of frames carrying an audio signal includes frame characterizing logic configured to generate a set of filter parameters characterising the...
US20170226182 PD-1 MODULATION AND USES THEREOF FOR MODULATING HIV REPLICATION  
Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs...
US20170220850 SYSTEM FOR INTERPRETATION OF IMAGE PATTERNS IN TERMS OF ANATOMICAL OR CURATED PATTERNS  
Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it...
9720792 Information theoretic caching for dynamic problem generation in constraint solving  
Computer-implemented techniques are disclosed for verifying circuit designs using dynamic problem generation. A device under test (DUT) is modeled as part of a test bench where the test bench is a...
9717782 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
US20170209687 DEEP BRAIN ELECTRODE PLACEMENT AND STIMULATION BASED ON BROWN ADIPOSE TISSUE TEMPERATURE  
Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a...
9715368 Computerized information and display apparatus with rapid convergence algorithm  
A computerized information and display apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, touch screen input and...
US20170204195 ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF  
Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an...
9710225 Computerized information and display apparatus with automatic context determination  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and speech input apparatus, touch...
9709972 Computerized information and display apparatus with remote environment control  
A computerized information apparatus useful for providing information to a user via a display. In one embodiment, the apparatus comprises a processor apparatus, and first wireless interface, radio...