Patents and Patent Applications from Oregon Health and Science University


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US20180267061 Type X Collagen Assays and Methods of Use Thereof  
The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b)...
US20180263634 PERCUTANEOUS VASCULAR INJURY TREATMENT SYSTEMS AND METHODS  
The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and...
US20180263490 SYSTEMS AND METHODS FOR AUTOMATED SEGMENTATION OF RETINAL FLUID IN OPTICAL COHERENCE TOMOGRAPHY  
Disclosed herein are methods and systems for the identification and characterization of fluid accumulation in the retina using OCT imaging. The disclosed methods and systems are directed to the...
10078091 Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and LC/MS/MS workflow  
A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or...
10076246 Method and apparatus for noninvasive quantitative detection of fibrosis in normal and viable myocardium by MRI  
Embodiments provide a noninvasive quantitative method for detecting extent and/or types of fibrosis in the heart. In embodiments, information pertaining to the extent and/or types of fibrosis may...
10071027 Dental composites  
Disclosed herein are methacrylate compounds that can be used as components of dental composites. Also disclosed are dental composites comprising the compositions and thiourethane oligomers.
10070784 OCT vitrectomy probe  
Disclosed herein are vitrectomy probes configured for use with optical coherence tomography.
US20180245165 SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA  
The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
US20180242862 IN VIVO OPTICAL FLOW IMAGING  
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT...
US20180221665 ELECTRODE PLACEMENT AND STIMULATION BASED ON BROWN ADIPOSE TISSUE TEMPERATURE  
Systems and methods for spinal cord electrode placement and spinal cord stimulation their use for treatment of conditions such as obesity are disclosed. In one example approach, during placement...
US20180214160 PERCUTANEOUS VASCULAR INJURY TREATMENT SYSTEMS AND METHODS  
The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and...
10037613 Systems and methods to track vehicles proximate perceived by an autonomous vehicle  
The present disclosure provides systems and methods for tracking vehicles or other objects that are perceived by an autonomous vehicle. A vehicle filter can employ a motion model that models the...
10023538 Compounds, compositions and associated methods comprising 3-aryl quinolines  
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and...
US20180196034 Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model  
Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
10010356 Bone plates, screws and instruments  
Systems for trauma and/or joint fusion implants and instruments include transarticular screw and intra-articular washer, polyaxial screw and plate, single- and multi-level polyaxial bone clamps,...
US20180182082 SYSTEMS AND METHODS FOR REFLECTANCE-BASED PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Embodiments provide systems and methods associated with a reflectance-based projection-resolved (rbPR) optical coherence tomography angiography (OCTA) algorithm which uses optical coherence...
US20180180309 HIGH EFFICIENCY SCALABLE STRUCTURE  
A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that...
10001635 Rapid confocal microscopy to support surgical procedures  
One embodiment of techniques for confocal microscopy includes illuminating a spot on a surface of a biological sample. A first emission intensity from the spot is detected in a first range of...
9989528 Synthetic olgononucleotides for detection of nucleic acid binding proteins  
Synthetic oligonucleotides that comprise a nucleic acid binding protein binding site, PCR primer sequences, and tag sequences that do not bind to nucleic acid binding proteins, with a total length...
9984464 Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography  
Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection...
9982241 Recombinant HCMV and RHCMV vectors and uses thereof  
The recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors of this invention encode heterologous antigens, such as pathogen-specific antigens or tumor antigens, which...
US20180133321 CYTOMEGALOVIRUS VECTORS ELICITING T CELLS RESTRICTED BY MAJOR HISTOCOMPATIBILITY COMPLEX E MOLECULES  
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV....
9970059 Survival predictor for diffuse large B cell lymphoma  
The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
9962542 Deep brain electrode placement and stimulation based on brown adipose tissue temperature  
Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a...
9962407 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
US20180116669 CLIPS AND APPLICATOR FOR TISSUE CLOSURE  
Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a...
9957508 Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome  
Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the...
9939911 Computer interface for remotely controlled objects and wearable articles with absolute pose detection component  
A remotely controlled object (e.g., an aircraft) or a wearable article (e.g., virtual or augmented reality glasses) using high optical contrast features and a photodetector that detects light...
D814286 Yoke collar  
9933173 High efficiency scalable structure  
A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that...
US20180087069 CYTOMEGALOVIRUS VECTORS ENABLING CONTROL OF T CELL TARGETING  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
9926565 Aptamer-RNAi therapeutic compositions  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORĪ³2 is described herein. Pharmaceutical compositions comprising the...
9926360 Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T-cells  
The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have...
9918972 Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents  
Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate,...
9918630 Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography  
A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed....
9918627 Aqueous cell differentiation in anterior uveitis using optical coherence tomography  
Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data...
US20180066321 GENE EXPRESSION PANEL FOR BREAST CANCER PROGNOSIS  
The invention described in the application relates to a panel of gene expression markers for node-negative, ER-positive, HER2-negative breast cancer patients. The invention thus provides methods...
US20180064733 USE OF BISPHOSPHONATES AS HIV/AIDS ADJUNCTIVE TREATMENT  
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an...
US20180057472 DERIVATIVES OF SOBETIROME  
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
US20180055881 IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
9898310 Symmetrical dimensions in context-oriented programming to optimize software object execution  
A method, system, and/or computer program product optimizes execution of a computation. Multiple slots, each of which is a container for information, are defined. A coordinate tuple is defined for...
9883866 Clips and applicator for tissue closure  
Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a...
9883810 In vivo optical flow imaging  
Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split...
9881520 Virtual tool manipulation system  
In the field of virtual reality, virtual tool manipulation systems and related methods and software are described in the present disclosure. One implementation of a virtual tool manipulation...
9879020 GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma  
Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target...
US20180025495 SYSTEMS AND METHODS OF CHOROIDAL NEOVASCULARIZATION DETECTION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection...
US20180023119 SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF  
Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic...
US20180020909 AUTOMATED QUANTIFICATION OF NONPERFUSION IN THE RETINA USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of...
US20180016599 Recombinant Cytomegalovirus Vectors As Vaccines For Tuberculosis  
The present disclosure provides cytomegalovirus vectors encoding fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, cytomegalovirus...
US20180009760 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES  
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and...