Patents and Patent Applications from Oregon Health and Science University


Match Document Document Title
10001635 Rapid confocal microscopy to support surgical procedures  
One embodiment of techniques for confocal microscopy includes illuminating a spot on a surface of a biological sample. A first emission intensity from the spot is detected in a first range of...
9989528 Synthetic olgononucleotides for detection of nucleic acid binding proteins  
Synthetic oligonucleotides that comprise a nucleic acid binding protein binding site, PCR primer sequences, and tag sequences that do not bind to nucleic acid binding proteins, with a total length...
9984464 Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography  
Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection...
9982241 Recombinant HCMV and RHCMV vectors and uses thereof  
The recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors of this invention encode heterologous antigens, such as pathogen-specific antigens or tumor antigens, which...
US20180133321 CYTOMEGALOVIRUS VECTORS ELICITING T CELLS RESTRICTED BY MAJOR HISTOCOMPATIBILITY COMPLEX E MOLECULES  
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV....
9970059 Survival predictor for diffuse large B cell lymphoma  
The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
9962542 Deep brain electrode placement and stimulation based on brown adipose tissue temperature  
Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a...
9962407 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
US20180116669 CLIPS AND APPLICATOR FOR TISSUE CLOSURE  
Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a...
9957508 Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome  
Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the...
9939911 Computer interface for remotely controlled objects and wearable articles with absolute pose detection component  
A remotely controlled object (e.g., an aircraft) or a wearable article (e.g., virtual or augmented reality glasses) using high optical contrast features and a photodetector that detects light...
D814286 Yoke collar  
9933173 High efficiency scalable structure  
A building may include a floor, a dome having a vent, and an internal ceiling that divides areas underneath the dome into first and second chambers. The internal ceiling may have an aperture that...
US20180087069 CYTOMEGALOVIRUS VECTORS ENABLING CONTROL OF T CELL TARGETING  
CMV vectors comprising a heterologous protein antigen, an active UL131 protein (or an ortholog thereof), and an active UL128 protein (or an ortholog thereof) but lacking an active UL130 protein...
9926565 Aptamer-RNAi therapeutic compositions  
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORĪ³2 is described herein. Pharmaceutical compositions comprising the...
9926360 Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T-cells  
The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have...
9918972 Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents  
Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate,...
9918630 Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography  
A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed....
9918627 Aqueous cell differentiation in anterior uveitis using optical coherence tomography  
Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data...
US20180066321 GENE EXPRESSION PANEL FOR BREAST CANCER PROGNOSIS  
The invention described in the application relates to a panel of gene expression markers for node-negative, ER-positive, HER2-negative breast cancer patients. The invention thus provides methods...
US20180064733 USE OF BISPHOSPHONATES AS HIV/AIDS ADJUNCTIVE TREATMENT  
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an...
US20180057472 DERIVATIVES OF SOBETIROME  
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
US20180055881 IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
9898310 Symmetrical dimensions in context-oriented programming to optimize software object execution  
A method, system, and/or computer program product optimizes execution of a computation. Multiple slots, each of which is a container for information, are defined. A coordinate tuple is defined for...
9883866 Clips and applicator for tissue closure  
Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a...
9883810 In vivo optical flow imaging  
Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split...
9881520 Virtual tool manipulation system  
In the field of virtual reality, virtual tool manipulation systems and related methods and software are described in the present disclosure. One implementation of a virtual tool manipulation...
9879020 GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma  
Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target...
US20180025495 SYSTEMS AND METHODS OF CHOROIDAL NEOVASCULARIZATION DETECTION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection...
US20180023119 SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF  
Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic...
US20180020909 AUTOMATED QUANTIFICATION OF NONPERFUSION IN THE RETINA USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of...
US20180016599 Recombinant Cytomegalovirus Vectors As Vaccines For Tuberculosis  
The present disclosure provides cytomegalovirus vectors encoding fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, cytomegalovirus...
US20180009760 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES  
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and...
9862972 CMV glycoproteins and recombinant vectors  
Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of...
9861517 Vessel closure member, delivery apparatus, and method of inserting the member  
An apparatus which includes a closure member and delivery systems for closing vessels in the body of a patient is disclosed. In one embodiment, the closure member is a hemostatic closure member...
US20180000342 DIAGNOSTIC CLASSIFICATION OF CORNEAL SHAPE ABNORMALITIES  
Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which...
US20170369577 RECOMBINANT CD74 POLYPEPTIDES  
Disclosed are recombinant CD74 polypeptides mutated relative to the naturally occurring CD74 polypeptides with improved properties such as binding of CD74 ligands such as MIF and RTL1000 as well...
US20170368164 SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA)...
US20170362590 PHARMACEUTICAL COMPOSITIONS COMPRISING MICRORNA  
Pharmaceutical compositions comprising one or more of miR-494-3p, miR-99b-5p, and/or miR-21-3p and a pharmaceutically acceptable carrier as well as methods of using said compositions to treat...
US20170360962 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES  
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human...
9839678 Human tissue kallikrein 1 glycosylation isoforms  
Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical...
US20170350887 CMV GLYCOPROTEINS AND RECOMBINANT VECTORS  
This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues...
US20170348433 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES  
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human...
US20170333009 INSTRUMENTS USED IN COLLECTING FLUID SAMPLES  
Disclosed are instruments used in collecting fluid samples from a subject such as, for example, aqueous humor samples. The instrument involves a linear actuator that, when engaged by the user via...
US20170332929 Method and System to Access Inapparent Conduction Abnormalities to Identify Risk of Ventricular Tachycardia  
A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to...
9820998 Use of bisphosphonates as HIV/AIDS adjunctive treatment  
The present invention relates to use of bisphosphonate formulations for the treatment and management of HIV/AIDS. The method of the invention comprises administering a formulation comprising an...
US20170319060 SYSTEMS AND METHODS TO COMPENSATE FOR REFLECTANCE VARIATION IN OCT ANGIOGRAPHY  
Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to...
9808485 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof  
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the...
9805145 Composite simulation modeling and analysis  
An aspect of combining simulation models includes a processor configured to process information relating to a plurality of simulated models. The processor collects the information to be processed...
9805143 Composite simulation modeling and analysis  
An aspect of handling a plurality of simulated models includes receiving from a first simulation model a stream of source data and determining data processing compatibility between the simulation...