Patents and Patent Applications from Ohio State University


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9791396 Space adaptive reconstruction technique for adaptive electrical capacitance volume tomography  
A capacitance system having a capacitance sensor provides a high resolution Spatial-Adaptive Reconstruction Technique (SART) for use with Adaptive Electrical Capacitance Volume Tomography (AECVT)....
US20170291253 HYBRID STRUCTURES FOR JOINING OF METALS AND CONTINUOUS FIBER MATERIALS  
A transition structure includes a metallic portion, a fiber portion including a plurality of tows embedded within the metallic portion and extending out from the metallic portion forming a fabric,...
9783513 STAT3 inhibitors and their anticancer use  
In one aspect, the invention relates to substituted 6-amino-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamide analogs and derivatives thereof, substituted 4-amino-5H-naphtho[1,8-cd]isothiazol-5-one...
9782176 Collapsible anvil head and stapling apparatus  
Various implementations of the invention provide for a one-piece surgical stapling apparatus that includes a stapler head and an anvil head assembly. The anvil head assembly is tiltable between a...
US20170281740 SERODIAGNOSIS OF SALMON POISONING DISEASE  
Neorickettsia helminthoeca is an obligate intra-cytoplasmic bacterium that causes salmon poisoning disease (SPD), an acute, febrile, fatal disease of dogs. Disclosed are compositions and methods...
US20170281723 IMPROVED PEPTIDYL CALCINEURIN INHIBITORS  
Improved calcineurin inhibitors and methods of using these improved calcineurin inhibitors to inhibit calcineurin-NFAT signaling in cells and in subjects are disclosed.
9777920 Oxygen carrying materials  
In accordance with one embodiment of the present disclosure, an oxygen carrying material may include a primary active mass, a primary support material, and a secondary support material. The oxygen...
9777265 Non-contact method for accelerating wound healing using an electromagnetic coil to induce an electric field transverse to an axis of the wound  
A method for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The method of the present...
US20170279739 PREDICTIVE NETWORK SYSTEM AND METHOD  
A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless...
US20170275625 Methods Of Inhibiting Tumorigenesis In Colon Adenocarcinoma And Compositions Therefor  
Described herein are methods and compositions for the treatment of colon cancers.
US20170273608 IONIC BARRIER FOR FLOATING GATE IN VIVO BIOSENSORS  
An ion-sensitive sensor includes a dielectric layer comprising Al2O3 having a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic...
US20170272158 DRIVER SYSTEM WITH AN OPTICAL POWER BASED ISOLATED POWER SUPPLY  
The present invention relates to a driver system that can include an optical power based isolated power supply. The driver system can include an optical receiver that can be in communication with...
US20170269188 FOLDED TRANSDUCER ARRAY FOR COMPACT AND DEPLOYABLE WAVE-ENERGY GUIDING SYSTEM  
A wave energy guiding system is described that includes a structural substrate formed according to a folded-pattern topology including, for example, an origami-type folded-pattern topology such as...
US20170268591 DESIGNS AND MANUFACTURING METHODS FOR LIGHTWEIGHT HYPERDAMPING MATERIALS PROVIDING LARGE ATTENUATION OF BROADBAND-FREQUENCY STRUCTURE-BORNE SOUND  
A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental...
9757432 Materials and methods useful for treating glioblastorna  
The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when...
9757213 Hybrid dental implant  
The present invention provides for a hybrid dental implant having a screw body with at least one external thread, which includes an upper portion with an open ceiling configured to receive one or...
9750819 Lipid nanoparticle compositions and methods of making and methods of using the same  
Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.
9750405 Automated detection of eye alignment  
An example method for automatically measuring a subject's phoria while the subject fixates on a visual target can include capturing an image of at least one of the subject's eyes using an image...
9746654 Optical delay elements created from variations of the robert cell  
An optical delay device comprises a multi-pass optical cell including first and second facing curved mirrors defining an optical cavity. One curved mirror includes a spatially extended aperture,...
9744186 Substituted gemcitabine aryl amide analogs  
In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to substituted gemcitabine aryl amide analogs, methods of making...
US20170241817 Velocity Vector Field Mapping Using Electrical Capacitance Sensors  
The present invention provides a system and method for velocity vector field calculation at the voxel level of a multi-phase flow system using Electrical Capacitance Volume Tomography sensors.
9738709 Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease  
In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been...
US20170232501 HOT FORMING OF COOLING GALLERIES IN STEEL PISTONS  
A piston, particularly a piston for use in a diesel engine, particularly a heavy duty diesel engine, is formed from a billet of metal, such that the finished piston has a mass that is at least...
9732144 Infectious bursal disease (IBDV) vaccine compositions  
Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof.
9731134 Neuromodulatory method for treating chronic or refractory rhinitis  
One aspect of the present disclosure includes a method for treating chronic or refractory rhinitis in a subject. One step of the method includes implanting a therapy delivery system in the subject...
9731071 System and method for regulating endogenous neuromodulatory agent levels  
One aspect of the present disclosure includes a closed-loop therapy delivery system for regulating an endogenous level of a first neuromodulatory agent in a subject. The therapy delivery system...
US20170224833 SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS  
Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical...
US20170224259 MAGNETIC RESONANCE IMAGING METHOD TO NON-INVASIVELY MEASURE BLOOD OXYGEN SATURATION  
Methods for data acquisition and processing of magnetic resonance (MR) imaging to obtain the oxygen saturation (O2sat) of blood using a relationship between transverse relaxation time (T2) of...
9725716 Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease  
Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed are methods of delivering an antisense oligonucleotide to a target...
US20170218081 METHODS AND COMPOSITIONS RELATED TO ANTIBODY FRAGMENTS THAT BIND TO TUMOR-ASSOCIATED GLYCOPROTEIN 72 (TAG-72)  
Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
US20170216458 INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9  
The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example,...
9718888 Methods and compositions related to single chain antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72)  
Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
US20170211066 Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b  
Methods and compositions for the treatment of prostate associated disorders are disclosed.
US20170209838 COMPOSITE MEMBRANES FOR SEPARATION OF GASES  
Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, an inorganic layer disposed on the...
US20170209584 COMPOSITIONS FOR TARGETING MACROPHAGES AND OTHER CD206 HIGH EXPRESSING CELLS AND METHODS OF TREATING AND DIAGNOSIS  
Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.
US20170209504 PROBIOTIC FORMULATIONS AND METHODS FOR USE  
Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the...
9716312 Multiple-input multiple-output ultra-wideband antennas  
An example ultra-wideband (“UWB”) multiple-input multiple-output (“MIMO”) antenna operating across a continuous, wide-range frequency band can include a ground plane, a wideband monopole antenna...
9713625 MicroRNAs useful for treating ovarian cancer  
Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients.
US20170204269 METHOD OF ISOLATING BLUE ANTHOCYANIN FRACTIONS  
The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a...
US20170202969 COMPOUNDS AND COMPOSITIONS FOR TARGETING MACROPHAGES AND OTHER MANNOSE-BINDING C-TYPE LECTIN RECEPTOR HIGH EXPRESSING CELLS AND METHODS OF TREATING AND DIAGNOSIS USING SAME  
Provided are compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treatment and diagnosis using such compounds...
US20170202940 TRANSGENIC ALGAE FOR DELIVERING ANTIGENS TO AN ANIMAL  
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an...
9708612 Methods and compositions using miR-3151 in the diagnosis and treatment of thyroid cancer  
Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided.
9707096 Spinal fixation device  
A spinal fixation device includes a body having a first end defining an aperture, an engaging portion configured to engage a vertebral body, and an adjustment member configured to be received in...
US20170200906 GERMANANE ANALOGS AND OPTOELECTRONIC DEVICES USING THE SAME  
The present invention provides novel two-dimensional van der Waals materials and stacks of those materials. Also provided are methods of making and using such materials.
9700201 Rapid measurement of visual sensitivity  
Data is received characterizing a result of a first visual sensitivity test assessing capacity to detect spatial form across one or more different target sizes, and different contrasts. Using the...
US20170196074 LIQUID THIN-FILM LASER TARGET  
Described in this disclosure is a laser target comprised of a liquid film creation device that is configured to form a liquid laser target. Methods of forming a liquid thin-film laser target are...
US20170190743 CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF  
Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can...
9695153 Oligooxopiperazines for p53 reactivation  
The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal...
US20170184614 Methylated Peptides Derived from Tau Protein and their Antibodies for Diagnosis and Therapy of Alzheimer's Disease  
In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been...
US20170184589 PROTEOMICS BASED DIAGNOSTIC DETECTION METHOD FOR CHRONIC SINUSITIS  
The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic...