Patents and Patent Applications from Ohio State University


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10080899 Systems and methods for treating autonomic instability and medical conditions associated therewith  
One aspect of the present disclosure relates to a closed-loop therapy system for treating autonomic instability or a medical condition associated therewith in a subject. The therapy delivery...
US20180264017 CARBORANE COMPOUNDS AND METHODS OF USE THEREOF  
Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ERβ) agonists. In some examples, the compounds can be selective ERβ...
10076666 Systems and methods for treating post-traumatic stress disorder  
One aspect of the present disclosure relates to a closed loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing...
US20180262277 DATA DELIVERY USING ACOUSTIC TRANSMISSIONS  
Systems, methods, and computer program products for delivering information to an individual, group, or device. The information is carried by audio signals beyond the audible frequency range of...
US20180259604 LOW FIELD MAGNETIC RESONANCE IMAGING (MRI) SCANNER FOR CARDIAC IMAGING  
A low-cost magnetic resonance imaging (MRI) apparatus that may be used for, e.g., Cardiac MRI (CMR). CMR is a clinical imaging tool that can investigate a wide range of cardiac conditions by...
10074814 Germanane analogs and optoelectronic devices using the same  
The present invention provides novel two-dimensional van der Waals materials and stacks of those materials. Also provided are methods of making and using such materials.
US20180254463 ACTIVE MEMBRANE WITH CONTROLLED ION-TRANSPORT  
A membrane is provided that includes a membrane substrate defining a plurality of pores to allow ion transport therethrough; an ion-doped conductive polymer disposed on a surface of the membrane...
10066027 Protein production systems and methods thereof  
Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and...
10065037 Systems for treating post-traumatic stress disorder  
One aspect of the present disclosure relates to a closed-loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing...
US20180246178 SYSTEMS AND METHODS FOR ESTIMATING COMPLEX B1+ FIELDS OF TRANSMIT COILS OF A MAGNETIC RESONANCE IMAGING (MRI) SYSTEM  
Systems and methods for estimating complex transmit field B1+ a transmit coil of a magnetic resonance imaging (MRI) system in both k-space and image domains are described herein. Estimating...
US20180245186 TITANIUM ALLOYS FOR ADDITIVE MANUFACTURING  
Disclosed are titanium alloys for use in additive manufacturing that comprise a titanium material and a beta eutectoid stabilizer. The beta eutectoid stabilizer can be present in an effective...
US20180243228 NANOPARTICLE BASED VACCINE STRATEGY AGAINST SWINE INFLUENZA VIRUS  
Disclosed herein are methods and compositions for treating or preventing swine influenza in a subject.
10063063 Harmonic harvester for improved RF-to-DC rectifying efficiency  
A harmonic harvesting circuit design for harvesting un-rectified AC power contained in the fundamental and harmonic frequencies at the output of conventional rectifying circuits.
10059733 Gemcitabine analogs  
Gemcitabine analogs, including monophosphorylated analogs, are described herein and are suitable for use in pharmaceutical compositions, kits and treatment methods. The treatment methods include...
US20180237941 METHODS FOR FORMING NANOWIRE PHOTONIC DEVICES ON A FLEXIBLE POLYCRYSTALLINE SUBSTRATE  
An example method of forming a photonic device is described herein. The method can include providing a flexible polycrystalline substrate, and growing a nanowire heterostructure on the flexible...
US20180237519 BIVALENT ANTIBODY DIRECTED AGAINST NKG2D AND TUMOR ASSOCIATED ANTIGENS  
A polypeptide is disclosed that binds tumor-associated antigens (TAA) on the surface of cancer cells and a NKG2D receptor. The NKG2D receptor is expressed on the surfaces of killer cells such as...
US20180231581 CANTILEVER FOR ATOMIC FORCE MICROSCOPY  
A cantilever system for use in an atomic force microscope (AFM) is disclosed. The cantilever system comprises a base cantilever portion and a paddle connected to the base cantilever portion with...
10048261 Proteomics based diagnostic detection method for chronic sinusitis  
The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic...
US20180226154 SYSTEM AND METHOD FOR SEGMENTATION AND AUTOMATED MEASUREMENT OF CHRONIC WOUND IMAGES  
Disclosed are systems and methods for automated monitoring of the size, area or boundary of chronic wound images. The disclosure includes use of a probability map that measures the likelihood of...
US20180223283 ANTISENSE FINGERLOOP RNAS AND USES THEREOF  
The present disclosure relates to chimeric antisense nucleotides and methods for modulating protein expression levels and/or RNA stability from at least two target mRNAs in a cell simultaneously.
US20180221859 OXYGEN CARRYING MATERIALS AND METHODS FOR MAKING THE SAME  
A method for producing an oxygen carrying material may include forming a mixture that includes powders of active mass precursor, support material precursor, and inert structure precursor, and...
US20180220970 SYSTEMS AND METHODS FOR DELIVERING AN IMPLANTABLE DEVICE  
The delivery system may include, for example, an outer catheter having a distal tip and an inner support member, such as an inner catheter, disposed within the outer catheter. The inner support...
10039833 Drug delivery system to increase bioavailability  
Drug delivery systems and compositions, comprising a glidant, that increase the bioavailability of biopharmaceutic class II, III, or IV active agents, and methods of making the same, are provided.
US20180208997 METHODS, COMPOSITIONS, AND DEVICES UTILIZING MicroRNA TO DETERMINE PHYSIOLOGICAL CONDITIONS  
Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their...
US20180208993 HIGHLY SENSITIVE METHODS FOR DETECTING BTK RESISTANCE MUTATIONS IN RNA AND DNA  
Disclosed is a highly sensitive mutation-specific quantitative polymerase chain reaction (PCR) assay to detect BTK mutations in B cells.
US20180207202 METHODS FOR MOBILIZING HEMATOPOIETIC STEM CELLS  
Disclosed are methods of mobilizing hematopoietic cells in a subject by administering to the subject a combination of Flt3 ligand (FLT3L) and a cell adhesion inhibitor. Also disclosed are methods...
10030273 MicroRNA expression in human peripheral blood microvesicles and uses thereof  
The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein.
10030045 Primers and methods for nucleic acid amplification  
A primer and method for amplification of a target nucleic acid, the primer adapted to conform into a conformation that dissociates from a complementary strand of DNA duplex. The conformation may...
10028933 Compositions and methods for inhibiting the growth of multi-drug resistant microbes  
Compositions and methods for preventing and treating infection with multi-drug resistant bacteria with AR-13 alone or in combination with antibiotics are provided.
US20180202543 SYSTEM AND METHOD FOR SIMULTANEOUS LOAD TRANSFER AND SPEED SYNCHRONIZATION IN GEARSHIFTS INVOLVING MULTIPLE ACTIVELY CONTROLLED CLUTCHES IN AUTOMATIC TRANSMISSIONS  
This invention pertains to the field of power transmission. Machines using a power transmission mechanism for transmission of the mechanical power produced by a source (engine (2), electric motor,...
US20180200416 SYSTEMS AND METHODS FOR MECHANICAL DISPLACEMENT OF AN ESOPHAGUS  
An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a...
10022693 Systems and methods for partial or complete oxidation of fuels  
A system used for converting multiple fuel feedstocks may include three reactors. The reactor system combination can be so chosen that one of the reactors completely or partially converts the fuel...
10022342 Methods and compositions for treating multiple myeloma  
Methods and compositions for sensitizing multiple myeloma cells to treatment with IMiDs are provided. Aspects include methods of administering AR-42 and an IMiD (e.g., lenalidomide, pomalidomide)...
US20180195127 MIRNA BIOMARKERS FOR RADIATION BIODOSIMETRY  
Disclosed herein are miRNA biomarkers and methods for measuring exposure of a mammalian subject to ionizing radiation using a cell-free biological sample. Also disclosed are dosimeters and methods...
US20180194831 METHODS AND COMPOSITIONS RELATING TO ANTI-NUCLEOLIN RECOMBINANT IMMUNOAGENTS  
Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind nucleolin (NCL). Also disclosed are treating and diagnosing diseases using single...
10018697 Method for estimating a GRAPPA reconstruction kernel  
A method for improving the signal-to-noise ratio (SNR) of TGRAPPA. The SNR of the ACS lines is proportional to the condition number of the GRAPPA kernel encoding equations. Therefore, the GRAPPA...
10016656 Automatically adjustable treadmill control system  
Systems and methods are described for automatically adjusting the speed of a treadmill system. The system periodically receives outputs from the range sensor indicative of the position of a user...
10016599 Devices, systems, and methods for treating obstetric and gynecological disorders  
One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery...
US20180187238 SELECTIVE MEDIA AND USES THEREOF  
The present embodiments provide for media useful for selection and enrichment of Salmonella species. In a particular embodiment, the medium is a minimal medium that includes fructose-asparagine as...
US20180185502 IMMOBILIZATION OF BIOMOLECULES BY SELF-ASSEMBLED NANOSTRUCTURES  
Disclosed are nanostructures such as carboxysomes that encapsulate RubisCO and carbonic anhydrase to provide a protected environment to maximize CO2 assimilation. Conditions are disclosed were...
US20180185469 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME  
Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.
US20180185334 COMPOSITIONS AND METHODS FOR INHIBITING LEISHMANIA  
Compositions and methods for inhibiting Leishmaniasis using AIs are provided. Aspects provide compositions and methods for administering AIs alone or in combination with other compounds to...
10012986 Method for autonomously parking a motor vehicle for head-in, tail-in, and parallel parking spots  
A method for autonomously parking a motor vehicle in various types of parking spots includes the steps of receiving a map of a parking area, locating the motor vehicle within the parking area,...
10010847 Circulating fluidized bed with moving bed downcomers and gas sealing between reactors  
A system and process for carrying out one or more chemical reactions are provided and include one or more chemical reactors having particulate solids forming a bed therein, and a gas stripping...
US20180181555 REWRITING FORMS FOR CONSTRAINED INTERACTION  
The innovation describes and discloses methods and systems that improve system performance for technical communication systems by providing transformed forms from input form attributes and a...
US20180171326 GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF THE METASTATIC POTENTIAL OF CANCER CELLS  
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of...
10000521 Substituted gemcitabine bicyclic amide analogs and treatment methods using same  
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical...
US20180158577 SUPERCONDUCTING WIRES AND METHODS OF MAKING THEREOF  
Disclosed herein are superconducting wires. The superconducting wires can comprise a metallic matrix and at least one continuous subelement embedded in the matrix. Each subelement can comprise a...
US20180154555 AGILE TOOLING  
A system and manufactures are provided that augment various manufacturing processes by combining skinning techniques, for example from additive manufacturing methods, with modular substructures in...
US20180153658 ANATOMICAL ARTICULATOR FOR DENTAL DIAGONOSTIC METHOD AND PROSTHETIC RECONSTRUCTION  
An anatomical articulator for modeling a temporomandibular joint includes a lower base portion comprising at least one upright support. A set of replica condyles produced from digital data...