Patents and Patent Applications from Northwestern University


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US20180193639 DEVICES FOR MATERIAL DELIVERY, ELECTROPORATION, SONOPORATION, AND/OR MONITORING ELECTROPHYSIOLOGICAL ACTIVITY  
The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the...
US20180193484 NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER  
Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (BBB) and is thus effective in the...
10017728 Methods for making ribosomes  
A platform for preparing a sequence defined biopolymer in vitro is disclosed. The platform includes a ribosome-depleted cellular extract ribosomal RNAs prepared by in vitro transcription and...
10016499 Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same  
The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the...
US20180188205 SYSTEM AND METHOD FOR ELECTRICAL CHARACTERIZATION OF ELECTRICAL MATERIALS  
Systems and methods can provide a fast and accurate way to measure conductivity and Hall effect, such that transient conductivities, transient carrier densities or transient mobilities can be...
US20180187189 Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications  
Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
US20180183423 System and Method for Anti-Ambipolar Heterojunctions from Solution-Processed Semiconductors  
Van der Waals heterojunctions are extended to semiconducting p-type single-walled carbon nanotube (s-SWCNT) and n-type film that can be solution-processed with high spatial uniformity at the wafer...
US20180180814 PROBE APPARATUS FOR MEASURING DEPTH-LIMITED PROPERTIES WITH LOW-COHERENCE ENHANCED BACKSCATTERING  
Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information...
10007341 Touch interface device and method for applying lateral forces on a human appendage  
A touch interface device includes a touch surface configured to be engaged by an object, first and second actuator assemblies operably connected to the touch surface, and a controller operably...
US20180170878 PHOTOCROSSLINKING REAGENTS AND METHODS OF USE THEREOF  
Provided herein are photocrosslinking reagents, crosslinkable proteins displaying photocrosslinking groups, crosslinked protein-protein complexes, and methods of use thereof.
US20180169040 MICROTUBULE POLYMERIZATION MODULATORS FOR TREATING LMNA-RELATED DILATED CARDIOMYOPATHY  
Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated...
US20180168808 Annuloplasty Ring For Receiving A Replacement Valve  
An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing...
10002998 Tin selenide single crystals for thermoelectric applications  
Thermoelectric materials and thermoelectric cells and devices incorporating the thermoelectric materials are provided. Also provided are methods of using the cells and devices to generate...
10002964 System and method for threshold logic with electrostatically formed nanowire transistors  
An electrostatically formed nanowire transistor, includes a source, a drain, and multiple gates surrounding a doped silicon region. The gates include a top gate, a bottom gate, and side gates. The...
US20180164657 OPTICAL QUANTIFICATION OF INTERFACIAL CHARGE STATES  
Methods of generating second harmonic generation (SHG) signals from interfaces formed with, or formed over, a noncentrosymmetric material, e.g., α-quartz, are provided. The methods make use of the...
US20180164447 CHALCO-PHOSPHATE-BASED HARD RADIATION DETECTORS  
Methods and devices for detecting incident radiation, such as incident x-rays or gamma-rays, are provided. The methods and devices use high purity, high quality single-crystals of inorganic...
9997272 Modular supramolecular approach for co-crystallization of donors and acceptors into ordered networks  
Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A...
9997271 Supramolecular networks with electron transfer in two dimensions  
Organic charge-transfer (CT) co-crystals in a crossed stack system are disclosed. The co-crystals exhibit bidirectional charge transfer interactions where one donor molecule shares electrons with...
9994935 Magnesium alloys having long-period stacking order phases  
Magnesium alloys comprising a long period stacking order (LPSO) phase having an 14H-i or an 18R-i structure are provided. The alloys comprise magnesium as a majority element, a first alloying...
9994817 Use of ligands for the programmed cell death receptor conjugated to solid supports for cultivating human regulatory T cells  
Disclosed are methods for isolating, cultivating, and/or cells including regulatory T cells (Tregs). The methods typically include cultivating cells including Tregs in a culture media comprising a...
9994766 Photoluminescent compounds  
Materials comprising an A/M/X compound are provided. An A/M/X compound is a compound comprising one or more A moieties, one or more M atoms and one or more X atoms, where the A moieties are...
9993449 (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma  
Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
US20180158621 CARBONACEOUS NANOPARTICLES, METHODS OF MAKING SAME AND USES THEREOF  
Compositions of carbonaceous nanoparticle fabrication and their use for electrode materials in supercapacitors are provided. The supercapacitor includes a first electrode having a first substrate...
US20180155295 CXCR4 CHEMOKINE RECEPTOR MODULATORS  
Provided herein are small molecule modulators of CXCR4 activity (e.g., agonists, antagonists, inverse agonists, partial agonists), and methods of use thereof (e.g., for the treatment of disease).
US20180154045 COMPOSITIONS AND METHODS FOR URINARY BLADDER REGENERATION  
The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells...
US20180154009 INJECTABLE THERMORESPONSIVE POLYELECTROLYTES  
Provided herein are compositions, devices, and systems comprising thermoresponsive, biodegradable elastomeric materials, and methods of use and manufacture thereof.
US20180153928 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME  
Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal...
US20180153853 INHIBITION OF CANCER CELL MOTILITY  
Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies...
US20180153839 COMPOSITIONS AND METHODS TO REDUCE PHARMACEUTICAL-INDUCED TOXICITY  
Provided herein are compositions and methods to reduce toxicity resulting from pharmaceutical treatment, that can lead to increased risk of developing Parkinson's disease (PD) and/or acceleration...
9987242 Treatment of Levodopa-induced Dyskinesias  
Provided herein are compositions and methods for the treatment and prevention of levodopa-induced dyskinesias (LID). In particular, M4 muscarinic receptor (M4R) positive allosteric modulators...
9986924 Implantable biomedical devices on bioresorbable substrates  
Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to...
US20180151515 SYSTEM AND METHOD FOR STRIPLINE ELECTRODES FOR THIN-FILM CHARACTERIZATION  
Systems and methods provide a device for characterizing a thin film, including a conducting or insulating substrate, an active layer on the conducting or insulating substrate to be characterized,...
9981968 Substituted pyrrolo[2,3-d]pyrimidines for the treatment of cancer and proliferative disorders  
Disclosed are substituted pyrrolo[2,3-d]pyrimidine compounds. The disclosed compounds are shown to be useful in inhibiting the growth of cancer cell lines and treating cancer and cell...
9980992 Lactobacillus with decreased lipoteichoic acid to reduce inflammatory responses  
Methods and compositions for treating or preventing inflammatory disorders are provided. The compositions of the invention comprise a recombinant bacterium genetically modified to decrease the...
9980976 Use of REDD1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists  
Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression and activity. The disclosed methods...
US20180145271 FLASHING RATCHETS  
Provided herein are flashing ratchets that produce transport based on the oscillating application of regularly-spaced, asymmetric potentials. In particular, devices are provided that transport...
US20180143293 FORWARD ACOUSTIC SCATTERING BASED DOUBLE-TRANSMITTER AND DOUBLE-RECEIVER NETWORKING TARGET DETECTION SYSTEM AND METHOD THEREOF  
The present invention relates to a forward acoustic scattering based double-transmitter and double-receiver networking target detection system and method thereof. Two transmitting ends and two...
US20180134581 Metal-Organic Frameworks for Adsorption of Liquid Phase Compounds  
The present invention provides for the use of a metal-organic framework (MOF) in removing particular chemical species or compounds, in particular oxy-anions, from a liquid or liquid stream. In...
US20180133711 MINIMALLY-INVASIVE COLLECTION SYSTEM FOR COLLECTING BIOLOGICAL SAMPLES FOR QUANTIFYING HEAVY METALS, OTHER TOXICANTS, PATHOGENS, AND BIOMARKERS  
Disclosed are devices, kits, compositions, and methods for collecting, transporting, and detecting toxicants, pathogens, and biomarkers in a biological sample. The devices, kits, compositions and...
US20180132756 MEDICAL EVALUATION SYSTEM AND METHOD USING SENSORS IN MOBILE DEVICES  
A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device...
9972799 Gate-tunable p-n heterojunction diode, and fabrication method and application of same  
A method of fabricating a diode includes forming a first semiconductor layer having a first portion and a second portion extending from the first portion on a substrate; forming first and second...
9971239 Silica polymer pen lithography  
Provided here are hard transparent polymer pen arrays, methods of printing indicia using the same, and methods of preparing the same.
9969905 Transient liquid phase (TLP) bonding of nickel based alloys by forming an aluminum-titanium coating and subsequent heat treatment  
Certain aspects of the invention provides a transient liquid phase (TLP) bonding structure, including Ni based alloys and a TLP bonded layer formed by pack cementation on the Ni based alloys using...
9969759 Duplex-selective organometallic DNA intercalators  
Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
9968642 Compositions and methods for treatment of pain  
The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or...
US20180129863 HIGH THROUGHPUT PARTIAL WAVE SPECTROSCOPIC MICROSCOPY AND ASSOCIATED SYSTEMS AND METHODS  
The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular,...
US20180128909 METHOD FOR OBTAINING HORIZONTAL LONGITUDINAL CORRELATION OF DEEP-SEA GREAT-DEPTH SOUND FIELD  
The present invention relates to a method for obtaining horizontal longitudinal correlation of a deep-sea great-depth sound field. Two testing positions with the same depth and different distances...
US20180128812 COMPOSITIONS AND METHODS FOR IDENTIFYING METABOLICALLY ACTIVE AGENTS  
The present invention relates to cells with altered cell cycle control. In particular, the present invention provides cells with altered cell cycle control and uses of such cells to identify...
US20180127833 CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS  
The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field...
US20180125990 MATERIALS FOR TISSUE REGENERATION  
Provided herein are materials for the promotion of tissue regeneration, and methods of promoting tissue regeneration and wound healing therewith. In particular, materials displaying...