Patents and Patent Applications from Northwestern University


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US20170293009 MAGNETIC BARCODE IMAGING  
Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance...
US20170291817 Purification of Carbon Nanotubes Via Selective Heating  
The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein...
US20170290944 Promotion of Wound Healing  
The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local...
9786845 Optical discs as low-cost, quasi-random nanoimprinting templates for photon management  
Methods of patterning a layer of a photonic device are provided using stamps or masks derived from pre-written optical media discs. One method comprises pressing a stamp on a surface of a layer of...
9783858 Altered microbiome of chronic pelvic pain  
Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels...
9783855 Cancer screening by detection of ultrastructural and molecular markers  
The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field...
9783525 Map kinase modulators and uses thereof  
The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further...
9783500 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition  
Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
US20170289707 HEARING ASSISTANCE DEVICE CONTROL  
A hearing assistance device may be a hearing aid worn on a person or a mobile device. The hearing assistance device may perform a hearing assistance algorithm based on signal processing...
US20170283467 PROGRAMMABLE POLYPEPTIDE AND NUCLEIC ACID NANOPARTICLES  
Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery of the nucleic acids into cells.
US20170281798 Synthetic Scaffolds for Metastasis Detection  
Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest...
US20170281680 Scaffold Delivery of Immune Suppressors and Transplant Material for Control of Transplant Rejection  
The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular...
9780791 Emitter-coupled spin-transistor logic  
A switch comprising a spin-transistor and a first control wire. The spin-transistor is configured so that when a magnetic field applied to the spin-transistor is less than a threshold value, the...
US20170275278 Mammalian and Bacterial Nitric Oxide Synthase Inhibitors  
Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of...
US20170269755 HAPTIC DEVICE WITH CONTROLLED TRACTION FORCES  
A haptic device comprising a substrate having a surface, a first actuator that modulates a friction experienced by a user's finger touching the substrate surface, a second actuator that oscillates...
US20170269172 Group III-V Ferromagnetic/Non-magnetic Semiconductor Heterojunctions and Magnetodiodes  
Ferromagnetic Group III-V semiconductor/non-magnetic Group III-V semiconductor heterojunctions, with a magnetodiode device, to detect heterojunction magnetoresistance responsive to an applied...
9766551 Heat actuated and projected lithography systems and methods  
In accordance with an embodiment of the disclosure, a method of patterning can include dividing an image into a set of frame sections; determining a tip pattern for a respective portion of an...
9765934 Thermally managed LED arrays assembled by printing  
Provided herein are electronic devices including arrays of printable light emitting diodes (LEDs) having device geometries and dimensions providing enhanced thermal management and control relative...
9765278 Energy efficient, temporary shear thinning siloxane lubricants and method of using  
A method of using energy-efficient lubricant compositions to reduce wear between two surfaces exposed to a high shear condition is provided. The lubricant compositions comprise polysiloxane base...
9765055 Intramolecular hydrogen-bonded nitric oxide synthase inhibitors  
Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
US20170260587 SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS  
Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and...
US20170260192 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS  
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are...
US20170260165 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase  
Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.
US20170258880 PEPTIDE CONJUGATED PARTICLES  
The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for...
US20170258870 LIMP-2 BASED PEPTIDES AND RELATED USES  
Disclosed are LIMP-2 peptides, LIMP-2 polypeptides, variants thereof, and pharmaceutical compositions comprising the LIMP-2 peptides, LIMP-2 polypeptides, or variants thereof. The disclosed...
9758507 Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors  
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
9757475 Templated nanoconjugates  
The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
9757255 Vacuum pump systems for prosthetic limbs and methods of using the same  
Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a...
US20170254817 BIOMARKERS IN NASAL EXHALED BREATH  
A method of diagnosing or assessing risk of a tauopathy in a person is disclosed. The method may comprise collecting a nasal sample of exhaled breath from the person's nose, analyzing the nasal...
US20170253581 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS  
Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be...
US20170253486 Stable Aqueous Dispersions of Optically and Electronically Active Phosphorene  
Methods for the preparation of few-layer phosphorene, compositions thereof and related devices fabricated therefrom.
9750845 Biodegradable nanocomposites with enhanced mechanical properties for soft tissue engineering  
The present invention is directed to a novel poly(diol citrates)-based nanocomposite materials created using completely biodegradable and biocompatible polymers that may be used in tissue...
US20170249014 INTERFACES AND METHODS OF DIGITAL COMPOSITION AND EDITING OF TEXTURES FOR RENDERING ON TACTILE SURFACES  
This disclosure provides designer interfaces that present condensed representations of texture functions, the representations displaying selected control points that manipulate the...
9749745 Low noise differential microphone arrays  
A differential microphone array includes a number (M) of microphone sensors for converting sound to a number of electrical signals, and a processor, operably coupled to the microphone sensors, to...
US20170239202 (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma  
Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
9738966 Chemically pure zero-valent iron nanofilms from a low-purity iron source  
Methods of forming chemically pure metal films are provided. The methods use electron beam deposition at a high mean deposition rate to form high purity metal films on deposition substrates. By...
9738665 Metallated metal-organic frameworks  
Porous metal-organic frameworks (MOFs) and metallated porous MOFs are provided. Also provided are methods of metallating porous MOFs using atomic layer deposition and methods of using the...
US20170232109 PROTEIN/OLIGONUCLEOTIDE CORE-SHELL NANOPARTICLE THERAPEUTICS  
The present disclosure is directed to core-shell nanoparticles, compositions comprising core-shell nanoparticles, and methods of their use.
9733746 Touch interface device having an electrostatic multitouch surface and method for controlling the device  
A touch interface device includes a touch surface, a first electrode, and a second electrode. The first electrode is coupled with the touch surface. The first electrode also configured to receive...
9732392 Modular sensor architecture for cell based biosensors  
The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting...
9732037 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors  
Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
US20170229742 PROTECTIVE CATHODE COATINGS FOR LITHIUM-ION BATTERIES  
Cathode coatings for lithium ion batteries, cathodes coated with the coatings, and lithium ion batteries incorporating the coated cathodes are provided. The coatings, which are composed of binary,...
US20170227947 AUTOMATED TOOLPATH GENERATION METHOD FOR DOUBLE SIDED INCREMENTAL FORMING  
An automated method for generating toolpaths in double sided incremental forming (DSIF) operations is disclosed which uses a geometrically constructed map to build a structure of all the geometric...
US20170224239 CYCLE LENGTH ITERATION FOR THE DETECTION OF ATRIAL ACTIVATIONS FROM ELECTROGRAM RECORDINGS OF ATRIAL FIBRILLATION  
A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the...
9728773 Electrode material comprising graphene-composite materials in a graphite network  
A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact...
9728636 System and method for threshold logic with electrostatically formed nanowire transistors  
An electrostatically formed nanowire transistor, includes a source, a drain, and multiple gates surrounding a doped silicon region. The gates include a top gate, a bottom gate, and side gates. The...
9725475 Arsenoplatin anti-cancer agents  
Disclosed herein are conjugates that include a ligand, and a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently...
US20170222724 ULTRAFAST ALL-OPTICAL MODULATION OF THE VISIBLE AND INFRARED SPECTRUM WITH NANOROD ARRAYS  
Disclosed herein is a method of optical modulation, the method comprising irradiating an optical switch with a control beam at a first control time and irradiating the optical switch with a signal...
US20170218174 IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE USING COMPOUNDS INCLUDING TRIHYDROXYPHENYL GROUPS  
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound...
US20170218135 VIOLOGEN-BASED ROTAXANES  
Disclosed herein are nanoactuating rotaxanes comprising a threading component, the threading component comprising a oligoviologen, and at least two macrocylic components, wherein the oligoviologen...