Patents and Patent Applications from Northeastern University


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US20180203005 Microdroplet Based Bioassay Platform  
Platform technology involving aqueous microdroplet reaction vessels created, arrayed, and characterized by imaging microscopy in a microfluidic device are applied to a wide variety of bioassays...
US20180202024 METHOD FOR PRODUCING TITANIUM OR TITANIUM ALUMINUM ALLOYS THROUGH TWO-STAGE ALUMINOTHERMIC REDUCTION AND OBTAINING TITANIUM-FREE CRYOLITE AS BYPRODUCTS  
A method for preparing titanium or titanium aluminum alloys through two-stage aluminothermic reduction and obtaining titanium-free cryolite as byproducts. The method has the following steps: (1)...
US20180201513 REDUCTION OF METAL/SEMI-METAL OXIDES  
This invention is concerned with the reduction of metal and/or semi-metal oxides. More particularly the invention relates to a method and apparatus adapted to produce silicon by reduction of...
US20180190380 Method And System For Adaptive Scheduling Of Clinical Assessments  
Methods and systems providing adaptive assessment of a physical subject to efficiently collect assessment data and modify an assessment schedule based on the analyses. The methods and systems can...
US20180187257 BIOMOLECULAR PROCESSING PLATFORM AND USES THEREOF  
The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure...
US20180180537 METHOD FOR ANALYZING BIOLOGICAL SPECIMENS BY SPECTRAL IMAGING  
A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to...
US20180179255 HEPARIN-BINDING CATIONIC PEPTIDE SELF-ASSEMBLING PEPTIDE AMPHIPHILES USEFUL AGAINST DRUG-RESISTANT BACTERIA  
Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.
US20180171296 Dendritic Cell Generator  
Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention...
10000452 Quinolone-based compounds, formulations, and uses thereof  
Provided herein are quinolone-based compounds that can be used for treatment and/or prevention of malaria and formulations thereof. Also provided herein are methods of treating and/or preventing...
US20180165318 Storage-Optimized Data-Atomic Systems and Techniques for Handling Erasures and Errors in Distributed Storage Systems  
Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum...
9998123 Impedance calibration device for semiconductor device  
An impedance calibration device for a semiconductor device includes a process sensor that detects a process condition for the semiconductor device and outputs a process signal, a temperature...
9994890 Methods of natural product drug discovery  
Disclosed are methods of identifying compounds that suppress the growth of target cells. In certain embodiments, the methods comprise providing a panel of target cells and the panel of target...
US20180155759 Method and Device for Cultivation and Analysis of Novel Microbial Species with Unknown Growth Requirements  
The invention provides devices and methods for automatically preparing pure cultures of microbial cells under native environmental conditions. The devices and methods permit the discovery and...
US20180155675 Method for Dedifferentiating and Culturing Microbial Species  
Methods and devices useful for reprogramming microbial cells to grow under different culture conditions are provided. The methods and devices can be used to prepare cultures of new, previously...
US20180145771 METHOD AND APPARATUS FOR WIRELESS COMMUNICATIONS  
Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an...
US20180141911 Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease  
A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be...
US20180138889 Microelectromechanical Resonant Circulator  
A microelectromechanical resonant circulator device is providing, having a substrate, and at least three electrical ports supported on the substrate. At least three electromechanical resonator...
US20180135118 Pinhole Zero-Mode Waveguides  
Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible...
9968259 Systems and methods for sensing, enumerating and imaging rare cells with diffuse light  
Diffuse fluorescence flow cytometers and methods of using them include a plurality of excitation sources and a plurality of detectors, all circumferentially arranged about a space for...
US20180131008 Nitrogen-Functionalized Platinum-Iridium Electrocatalyst  
The invention provides a nitrogen-functionalized platinum-transition metal catalyst having the formula Pt-M-Nx/C (where M is a transition element such as Fe, Co, Ni, Nb, Ta, Ir, Rh, or Ru) for use...
US20180128693 STOP-START METHOD IN A MICROFLUIDIC CALORIMETER  
A method for calorimetry includes flowing a first fluid through a co-flow reactor microchannel having plural inlets and an outlet, the first fluid flowing through each of the inlets, and measuring...
US20180125798 Compounds and Methods for Modulating Serotonin Receptors in the Periphery  
This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the GI...
9965722 Optimized decision-making system and method for multiple ore dressing production indexes based on cloud server and mobile terminals  
Provided is an optimized decision-making system for multiple ore dressing production indexes based on a cloud server and mobile terminals, including mobile intelligent terminals, a cloud server, a...
9963444 N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof  
A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine...
9963353 Method for recovering alkali and aluminum in course of treatment of bayer red mud by using calcification-carbonation method  
A method for recovering alkali and aluminum during treatment of Bayer red mud using a calcification-carbonation method, including steps of mixing the Bayer red mud with calcium aluminate or with...
9962448 Compounds and methods for targeted immune system delivery  
Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also...
US20180117071 Cationic Polymers As Co-Drugs For Chemotherapeutic Agents  
A method for treating a biological cell is disclosed. The method administers a mixture of a chemotherapeutic drug and a co-drug that facilitates delivery of the chemotherapeutic drug to the...
US20180114614 Rare Earth-Free Permanent Magnetic Material  
The invention provides rare earth-free permanent magnetic materials and methods of making them. The materials can be used to produce magnetic structures for use in a wide variety of commercial...
9954512 Nano- and micro-electromechanical resonators  
A resonator including a piezoelectric plate and an interdigital electrode is provided. A ratio between a thickness of the plate and a pitch of the interdigital electrode may be from about 0.5 to...
9939370 Phase correction to compensate for reflective distortions of optical spectra  
Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed.
US20180097499 Nano- and Microelectromechanical Resonators  
A resonator includes a piezoelectric plate and interdigitated electrode(s). The interdigitated electrode includes a plurality of conductive strips disposed over a top surface of the piezoelectric...
9935608 Nano- and microelectromechanical resonators  
A resonator includes a piezoelectric plate and interdigitated electrode(s). The interdigitated electrode includes a plurality of conductive strips disposed over a top surface of the piezoelectric...
9931418 Compositions for the delivery of RNA and drugs into cells  
Provided is a co-polymer of formula A-L-D, or a pharmaceutically acceptable salt thereof, wherein A is a linear, branched or dendritic polyamine; D is a lipid; and L is a linker comprising a water...
US20180085034 PREPULSE INHIBITION OF THE ACOUSTIC STARTLE REFLEX  
A method of evaluating hearing in a subject is described. The method includes delivering a pre-pulse auditory stimulus to the subject, allowing a stimulus gap from 10 to 200 milliseconds to pass,...
9927334 Methods, compositions and devices employing alginic acid hydrogels for highly specific capture and release of biological materials  
Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the...
9926275 Allosteric modulators of the cannabinoid 1 receptor  
The present technology relates to compounds and compositions of Formulas I, II, VII, and VIII, and methods using such compounds. The compounds and compositions described herein may be used in the...
9925388 Device and method for deep transcranial magnetic stimulation  
Devices and methods for directing a magnetic field into a body party of a subject are provided. The devices include at least one electromagnetic coil, a magnetic core or yoke, and a pair of flux...
9924372 Method for sharing of unlicensed radio frequency bands by cellular LTE and WiFi networks  
A coexistence scheme enables spectrally-efficient and fair spectrum sharing between a first wireless network and a coexisting wireless network in the same frequency bands. The spectrum sharing...
9921226 Sensor system utilizing piezoelectric microcantilever coupled with resonating circuit  
An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer...
9921187 Real-time pavement profile sensing system using air-coupled surface wave  
A non-contact testing system and method using acoustic sensors and a mobile sensing system using this system and method is disclosed. The leaky surface wave is recorded with directional...
US20180071739 Platform For Liquid Droplet Formation And Isolation  
Embodiments are directed to a platform for liquid droplet generation and isolation for biochemical sensing and testing. An embodiment includes generator, fluid-exchange, and manipulator structures...
9909173 Biomolecular processing platform and uses thereof  
The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure...
9891315 Conformal and configurable millimeter-wave integrated array radar in a compact package  
The invention provides a compact, high-frequency, transmit and receive millimeter-wave radar sensor device, system, and method of use. The sensor can operate at a variety of distances, speeds, and...
US20180038815 Nanotube-Based Biosensor for Pathogen Detection  
A simple and highly sensitive single walled carbon nanotube (SWNT) sensor is provided for detection of a variety of analytes, including small molecules, macromolecules, and pathogens. The high...
US20180038001 Low Noise Ultrathin Freestanding Membranes Composed of Atomically-Thin 2D Materials  
The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal...
US20180037924 Nanofluidic Device for Isolating, Growing, and Characterizing Microbial Cells  
Nanofluidic devices and methods of the invention are capable of autonomously isolating individual microbial cells using constrictive channels and growing monocultures of the cells for automated...
US20180036237 OIL/SURFACTANT MIXTURES FOR SELF-EMULSIFICATION  
Oil-in-water emulsions with small droplet sizes can be formed without requiring either microfluidisation or heating to cause phase inversion, but rather by simple mixing of a pre-mixed composition...
US20180028442 NANOEMULSION COMPOSITIONS OF TAXOID DRUGS, AND METHODS FOR THE USE THEREOF TO TARGET CANCER CELLS AND CANCER STEM CELLS  
A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering...
9881746 Flexible and transparent supercapacitors and fabrication using thin film carbon electrodes with controlled morphologies  
Mechanically flexible and optically transparent thin film solid state supercapacitors are fabricated by assembling nano-engineered carbon electrodes in porous templates. The electrodes have...
US20180027077 Software-Defined Implantable Ultrasonic Device for Use in the Internet of Medical Things  
Implantable and wearable devices and system for transmitting signals ultrasonically through biological tissue are implemented based on an Internet of Medical Things (IoMT) platform software and...