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Patents and Patent Applications from New York University


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8987412 Hydrogen bond surrogate macrocycles as modulators of Ras  
The present invention relates to peptides having one or more stable, internally-constrained HBS α-helices, where the peptide is capable of interacting with Ras and related proteins.
8982613 Scalable orthogonal spin transfer magnetic random access memory devices with reduced write error rates  
A magnetic device includes a pinned polarizing magnetic layer having a magnetic vector parallel to a plane of the pinned polarizing magnetic layer. The magnetic device also includes a free layer,...
8980284 Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery  
This invention relates to isolated Clostridium botulinum propeptides and neurotoxins, isolated nucleic acid molecules encoding Clostridium botulinum propeptides and neurotoxins, methods of...
US20150072991 OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM  
The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
US20150072364 METHODS AND KITS FOR DIAGNOSING OSTEOARTHRITIS AND PREDICTING PROGRESSION  
This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.
US20150067923 Transgenic Plants And A Transient Transformation System For Genome-Wide Transcription Factor Target Discovery  
Plant genes regulated by transcription factors that control the gene network response to an environmental perturbation or signal are described. This class of genes responds to the perturbation of a...
US20150067288 CORRUPTING DATA STRUCTURES FOR PRIVACY PROTECTION  
Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, for storing data in both defaultable and non-defaultable memory on a unit in such a way that if a...
US20150066594 SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR DETERMINING ONE OR MORE EFFECTS OF RANKINGS ON CONSUMER BEHAVIOR  
Exemplary systems, methods and computer-accessible mediums can be provided which can receive information related to a consumer(s), and determine the search behavior of the consumer(s) based on the...
US20150065436 INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES  
The present invention relates to peptidomimetics that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Methods of using the peptidomimetics to, e.g., inhibit the H...
US20150065376 EXPRESSION CONSTRUCTS ENCODING G PROTEIN COUPLED RECEPTORS AND METHODS OF USE THEREOF  
Expression vectors comprising a first nucleic acid sequence encoding a G protein coupled receptor (GPCR), wherein the GPCR encoded thereby is expressed as a fusion protein with a first detectable...
US20150062587 HOLOGRAPHIC MICROREFRACTOMETER  
An in-line holographic microscope is used for measurements of micrometer-scale particles and associated suspending fluid medium containing the particles. The system yields heterodyne scattering...
US20150057759 MEDIAL TIBIAL PLATEAU REALIGNMENT PROCEDURE FOR MEDIAL OSTEOARTHRITIS OF THE KNEE  
A method and apparatus for correcting varus deformity comprises cutting a horizontal slot in the upper medial portion of the tibia. The slot is opened by the application of external force and a...
US20150055845 System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging  
Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and...
US20150054635 HAPTIC FORCE-FEEDBACK FOR COMPUTING INTERFACES  
Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, provide two degrees of freedom active force feedback for touchscreens or any other general...
US20150054633 Interactive Tangible Interface for Hand Motion  
Methods, systems, and apparatuses, including computer programs encoded on computer-readable media are disclosed, for receiving, from an inertial measurement unit (IMU) the motion information of an...
8961987 Immunogen comprising the HIV GP120 V3 loop in a conformation that induces broadly neutralizing antibodies  
Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens...
US20150050289 MUSCLE SPECIFIC RECEPTOR KINASE AND MODULATION THEREOF  
Agents, compositions, and medicaments that pertain to modulating the activity of muscle specific kinase receptor (MuSK) and methods and uses thereof to modulate MuSK activity are encompassed...
US20150045766 MICROELECTRODE-EQUIPPED SUBDURAL THERAPEUTIC AGENT DELIVERY STRIP  
An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the...
US20150044243 MUCOSAL IMMUNIZATION TO PREVENT PRION INFECTION  
Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic...
US20150044228 METHODS TO IDENTIFY COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE AND DIFFERENTIATIVE DISORDERS  
The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention...
US20150044189 HYBRID POLYMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF SYNTHESIZING THE SAME  
Novel hybrid polymers are disclosed that have a structure represented by the following wherein Abiotic oligomer, Polypeptide, X, Y, and R1 are as described herein. The methods to prepare the hybrid...
8951938 Combinatorial rosamine library to detect cell-state switching  
The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for...
8951597 Graded glass/ceramic/glass structures for damage resistant ceramic dental and orthopedic prostheses  
The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded...
8951519 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins  
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
8951512 Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota  
The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic...
US20150037285 METHODS FOR EFFICIENT TRANSFER OF VIABLE AND BIOACTIVE MICROBIOTA  
The present invention relates to methods for transferring gastrointestinal microbiota that preserves viability and bioactivity of the microbiota, even if fastidious, anaerobic, and non-culturable...
8945851 Quantitative assay for membrane association of proteins  
The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a...
US20150032202 Drug-Eluting Stent and Method  
A drug-eluting stent is disclosed, the stent having an outer cylindrical portion, an inner cylindrical portion disposed within and substantially coaxial with the outer cylindrical portion, a...
US20150031793 MULTIFUNCTIONAL SYNTACTIC FOAMS  
A multifunctional syntactic foam including a matrix material and hollow particles, where a first and second material property of the syntactic foam are tailored on the basis of the wall thickness...
8941196 Precessional reversal in orthogonal spin transfer magnetic RAM devices  
Orthogonal spin-torque bit cells whose spin torques from a perpendicular polarizer and an in-plane magnetized reference layer are constructively or destructively combined. An orthogonal spin-torque...
US20150018364 CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS  
The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these o...
US20150015252 Methods and Kits for Detecting Non-Luminescent or Weakly Luminescent Metals  
The invention provides methods and kits for detecting the presence of, the amount of or the concentration of a substantially non-emitting metal in a sample by a) providing a sensitizer to a...
US20150014221 COMPOSITION, METHOD, AND APPARATUS FOR CRUDE OIL REMEDIATION  
Crude oil-contaminated objects are remediated by mixing crude oil-contaminated objects with an aqueous solution including co-solvents, electrolytes, and anionic surfactants. The co-solvents are...
US20150011728 REVERSIBLY CROSSLINKED HELICAL HYDROGEN BOND SURROGATE MACROCYCLES  
The present invention relates to peptides having one or more stable, reversibly and internally-constrained HBS α-helices.
US20150011610 METHOD FOR ENHANCING REMYELINATION USING GLI1 INHIBITORS  
The invention provides a method of treatment of multiple sclerosis and other neurological disorders characterized by myelin loss or myelin deficiency by inhibiting Gli1 transcription factor. In a...
US20150011496 METHODS AND COMPOSITIONS FOR STIMULATING BONE REGENERATION  
The invention provides methods and compositions for stimulating or promoting bone regeneration or repairing bone fracture or for stimulating or increasing differentiation or activation of...
US20150011465 PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions...
US20150004157 OSTEOPONTIN ISOFORM A INHIBITORS AND METHODS OF USE  
The present invention relates to a therapeutic comprising an osteopontin isoform a (“OPNa”) inhibitor where the OPNa inhibitor blocks activity of extracellular OPNa exon 4. The OPNa inhibitor is ...
US20150000666 System and Method for Circuits to Allow CPAP to Provide Zero Pressure  
A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end,...
8922857 Optical solenoid beams  
Optical solenoid beams, diffractionless solutions of the Helmholtz equation whose diffraction -limited in-plane intensity peak spirals around the optical axis, and whose wavefronts carry an...
8921763 Extended and knotted optical traps in three dimensions  
The present invention is directed toward a system and method for projecting holographic optical traps whose intensity maxima are extended along specified paths in three dimensions with specified...
US20140378531 INHIBITION OF PATTERN RECOGNITION RECEPTORS IN PANCREATIC CANCER TREATMENT USING TLR INHIBITORS  
The disclosure herein relates to the novel finding that pattern recognition receptor activation is central to pancreatic cancer progression, and provides antagonists of pattern recognition...
US20140378336 DIAGNOSIS OF CELL PROLIFERATIVE DISEASES  
The method of the present disclosure is directed towards a method and a kit for diagnosing a cell proliferative disease. This method includes the following steps; gathering a sample from a subject,...
US20140375353 SYSTEMS, PROCESSES AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING LOGIC ENCRYPTION UTILIZING FAULT ANALYSIS  
Exemplary systems, methods and computer-accessible mediums can encrypting a circuit by determining at least one location to insert at least one gate in the circuit using a fault analysis, and...
8916609 Compounds as L-cystine crystallization inhibitors and uses thereof  
A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: R1a—[O]v-(-A-L-)m-A-[O]v—R1b I, wherein A, L, R1a, R1b, m, and v are as described her...
US20140367812 SCALABLE ORTHOGONAL SPIN TRANSFER MAGNETIC RANDOM ACCESS MEMORY DEVICES WITH REDUCED WRITE ERROR RATES  
A magnetic device includes a pinned polarizing magnetic layer having a magnetic vector parallel to a plane of the pinned polarizing magnetic layer. The magnetic device also includes a free layer,...
8911935 Mitochondria and human immunodefiency virus type 1  
Methods described herein relate to mitochondria and their role in Human immunodeficiency virus type 1 (HIV-1) infection and cell-to-cell HIV-1 transmission and compositions and methods for...
8906382 Method for treating amyloid disease  
The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.
US20140356333 NAIL STEM CELLS AND METHODS OF USE THEREOF  
The present invention is directed to an in vitro method for promoting proliferation, survival, and/or differentiation of K14+, K17+ nail stem cells (NSCs). The instant methods may be used to...
US20140350078 CONTROLLING REGULATORY T CELL FUNCTION  
The present invention relates to a method of identifying candidate compounds useful as chemotherapeutics or anti-infective compounds or anti-inflammatory drugs. This method involves providing a...