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Patents and Patent Applications from New York University


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8911935 Mitochondria and human immunodefiency virus type 1  
Methods described herein relate to mitochondria and their role in Human immunodeficiency virus type 1 (HIV-1) infection and cell-to-cell HIV-1 transmission and compositions and methods for...
8906382 Method for treating amyloid disease  
The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.
US20140356333 NAIL STEM CELLS AND METHODS OF USE THEREOF  
The present invention is directed to an in vitro method for promoting proliferation, survival, and/or differentiation of K14+, K17+ nail stem cells (NSCs). The instant methods may be used to...
US20140350078 CONTROLLING REGULATORY T CELL FUNCTION  
The present invention relates to a method of identifying candidate compounds useful as chemotherapeutics or anti-infective compounds or anti-inflammatory drugs. This method involves providing a...
US20140341948 ATTENUATED NEGATIVE STRAND VIRUSES WITH ALTERED INTERFERON ANTAGONIST ACTIVITY FOR USE AS VACCINES AND PHARMACEUTICALS  
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
US20140340084 APPARATUS, SYSTEMS AND METHODS WHICH ARE BASED ON MAGNETIC RESONANCE IMAGING FOR EVALUATION(S) OF RADIO FREQUENCY EMITTING DEVICE(S)  
Exemplary system, method and computer accessible medium can be provided for evaluating at least one radio frequency transmitting arrangement. For example, it is possible to receive a first...
8889850 Inhibitors of heat shock RNA  
The present invention is directed to molecules that inhibit expression or a function of a eukaryotic Heat Shock RNA (HSR1) and their use for inhibiting a stress response or stress tolerance in a cell.
8889634 Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species  
This invention discloses isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH; SEQ ID NOS: 1 and 15) and analogs thereof as well as compositions comprising CEFH peptides...
8889621 Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia  
The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and...
8889615 Methods for promoting epithelialization and healing of chronic wounds  
Compositions for antagonizing phosphorylation and subsequent degradation of glycogen synthase kinase 3 beta (GSK3β) in epidermal cells are disclosed. GSK3β phosphorylation antagonists include m...
8889426 Methods of identifying inhibitors of FGF23 binding to the binary FGFR-klotho complex for the treatment of hypophosphatemia  
The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of...
8889367 Methods and kits for diagnosing osteoarthritis and predicting progression  
This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.
US20140336661 ANATOMIC SOCKET ALIGNMENT GUIDE AND METHODS OF MAKING AND USING SAME  
This disclosure provides an anatomic socket alignment guide set, for total hip replacement arthroplasty. The guide set is created from patient-specific medical images, allowing the guide set...
US20140335126 V1V2 IMMUNOGENS  
The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
US20140334518 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING SPECIFIC ABSORPTION RATE OBTAINED BASED ON MAGNETIC RESONANCE IMAGING AND TEMPERATURE PROPERTY MEASUREMENTS  
Systems, methods and computer-accessible mediums for determining a specific absorption rate (SAR) of a radio frequency (RF) radiation on an object(s) can be provided, which can, for example...
8883745 C—glycolipids with enhanced Th-1 profile  
The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells....
8883427 Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments  
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the...
US20140330002 Specificity, Flexibility and Valence of DNA Bonds for Guided Emulsion Architecture  
A method of forming an end product by self-assembly of a first component having a patch of a linker component, such as DNA strands, cadherins, adhesive proteins and nanoparticle linkers. Such...
8877156 Contrast agents anchored by thiols on nanoparticles  
The present invention is directed toward a multivalent product including a nanoparticle with a metal, metal alloy, or metal oxide core, a plurality of non-polymerizing ligands bound to the...
8871915 Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof  
The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The...
8871899 Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices  
The present invention relates to a peptide having one or more stable, internally-constrained HBS α-helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a ...
US20140314799 METHODS, AGENTS AND PEPTIDES FOR INHIBITING MATRIX METALLOPROTEINASE-2 SIGNALING  
Screening assays and methods of using same for screening to identify modulator agents or compounds that affect matrix metalloproteinase-2 (MMP-2) mediated activation of toll-like receptor-2 (TLR-2)...
US20140314298 SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUMS OR DETERMINING NEURODEGENERATION  
Method, system and computer-accessible medium for determining at least one of axonal loss or myelin degradation can be provided. For example, it is possible to receive data based on at least one of...
8868176 Microelectrode-equipped subdural therapeutic agent delivery strip  
An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the...
8865657 Compositions and methods for inactivating or suppressing inflammatory cells  
Methods are provided for reducing the activity or function of an inflammatory cell by contacting a cell with, or administering to a subject in need thereof, an effective amount of a...
8865186 Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof  
The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide...
8865129 Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof  
The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods...
US20140310224 PREDICTING TEMPERATURE RESPONSE  
After the temperature response to a single period of heating (SAR segment) is determined, temperature increases for an arbitrary timecourse of heating is determined based upon a convolution of the...
US20140310058 Identifying Influential and Susceptible Members of Social Networks  
Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for generating a message associated with a user, wherein the user is associated with a plurality...
US20140303927 SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR DETERMINING TISSUE THERMAL PROPERTY  
An exemplary system, method and computer-accessible medium for constructing information regarding a distribution of thermal properties of an objects), can be provided. For example, data related to...
US20140302046 Immunological Targeting of Pathological Tau Proteins  
The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide...
8854363 Method and apparatus for segmenting an image in order to locate a part thereof  
A method is disclosed to automatically segment 3D and higher-dimensional images into two subsets without user intervention, with no topological restriction on the solution, and in such a way that...
US20140298498 INHIBITION OF ONCOGENIC KRAS-INDUCED GM-CSF PRODUCTION AND FUNCTION  
The present invention is directed to methods of inhibiting tumor growth in a subject. The present invention is further directed to methods of diagnosing cancer in a subject and identifying a...
US20140294793 GPR15-MEDIATED HOMING AND USES THEREOF  
The present invention is directed to in vitro methods for promoting expression of G-protein coupled receptor 15 (GPR15) on T cells, GPR15+ enriched populations of T cells generated using these...
8846609 Leukotoxin E/D as a new anti-inflammatory agent and microbicide  
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject....
US20140288178 INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION  
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to...
US20140287959 NANOREACTOR PRINTING  
Polymer Pen Lithography is used to induce bioorthogonal reactions between treated surfaces and functionalized inks create a soft matter layer. Fluorescent and redox-active inks were used to...
US20140286955 NOTCH AGONISTS FOR THE TREATMENT OF CANCER  
The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a Notch receptor...
8841428 Polynucleotide nanomechanical device that acts as an artificial ribosome and translates DNA signals into polymer assembly instructions  
A polynucleic acid nanomechanical device with a linear array of alternating PX-JX2 devices and nucleic acid multi-crossover motifs that facilitate the assembly of a nucleic acid strand and...
8841322 Method for increasing the activity of lysosomal enzymes  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
US20140283217 Methods of Affecting Plant Growth With MicroRNA  
Provided herein are compositions and methods for producing transgenic plants. In specific embodiments, transgenic plants comprise a construct comprising a polynucleotide encoding microRNA167...
US20140274916 CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial...
US20140273209 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140273003 SUPER-RESOLUTION FLUORESCENCE LOCALIZATION MICROSCOPY  
The present invention relates generally ultrasensitive assays for use in diagnostics and in methods of drug screening and personalizing therapy for an individual patient. Specifically, the present...
8835835 Biomarkers of ionizing radiation  
The present invention provides novel radiation associated markers. The radiation associated markers may be one or more of albumin, LTGF-β, or any protein or peptide listed in any one of Tables 1, ...
8835619 Heat shock proteins from Mycobacterium leprae and uses thereof  
The present invention is directed to heat shock proteins from Mycobacterium leprae as well as their encoding polynucleotides and vectors and host cells containing these polynucleotides. These heat...
8835123 Methods for detecting progenitor cells and uses thereof  
Diagnostic and therapeutic methods pertaining to diseases and disorders of the breast, uterus and ovary are encompassed herein. More particularly, diagnostic methods for early detection of...
8833368 System and method for circuits to allow CPAP to provide zero pressure  
A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end,...
US20140256594 DNA PHOTOLITHOGRAPHY WITH CINNAMATE CROSSLINKERS  
The present invention relates generally to cinnamate crosslinkers. Specifically, the present invention relates to gels, biochips, and functionalized surfaces useful as probes, in assays, in gels,...
8828413 Peptoid oligomers, pharmaceutical compositions and methods of using the same  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions...