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Patents and Patent Applications from New York University


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8871915 Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof  
The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The...
8871899 Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices  
The present invention relates to a peptide having one or more stable, internally-constrained HBS α-helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a ...
US20140314298 SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUMS OR DETERMINING NEURODEGENERATION  
Method, system and computer-accessible medium for determining at least one of axonal loss or myelin degradation can be provided. For example, it is possible to receive data based on at least one of...
8868176 Microelectrode-equipped subdural therapeutic agent delivery strip  
An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the...
8865657 Compositions and methods for inactivating or suppressing inflammatory cells  
Methods are provided for reducing the activity or function of an inflammatory cell by contacting a cell with, or administering to a subject in need thereof, an effective amount of a...
8865186 Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof  
The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide...
8865129 Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof  
The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods...
US20140310224 PREDICTING TEMPERATURE RESPONSE  
After the temperature response to a single period of heating (SAR segment) is determined, temperature increases for an arbitrary timecourse of heating is determined based upon a convolution of the...
US20140310058 Identifying Influential and Susceptible Members of Social Networks  
Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for generating a message associated with a user, wherein the user is associated with a plurality...
US20140303927 SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR DETERMINING TISSUE THERMAL PROPERTY  
An exemplary system, method and computer-accessible medium for constructing information regarding a distribution of thermal properties of an objects), can be provided. For example, data related to...
US20140302046 Immunological Targeting of Pathological Tau Proteins  
The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide...
8854363 Method and apparatus for segmenting an image in order to locate a part thereof  
A method is disclosed to automatically segment 3D and higher-dimensional images into two subsets without user intervention, with no topological restriction on the solution, and in such a way that...
US20140298498 INHIBITION OF ONCOGENIC KRAS-INDUCED GM-CSF PRODUCTION AND FUNCTION  
The present invention is directed to methods of inhibiting tumor growth in a subject. The present invention is further directed to methods of diagnosing cancer in a subject and identifying a...
US20140294793 GPR15-MEDIATED HOMING AND USES THEREOF  
The present invention is directed to in vitro methods for promoting expression of G-protein coupled receptor 15 (GPR15) on T cells, GPR15+ enriched populations of T cells generated using these...
8846609 Leukotoxin E/D as a new anti-inflammatory agent and microbicide  
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject....
US20140288178 INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION  
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to...
US20140287959 NANOREACTOR PRINTING  
Polymer Pen Lithography is used to induce bioorthogonal reactions between treated surfaces and functionalized inks create a soft matter layer. Fluorescent and redox-active inks were used to...
US20140286955 NOTCH AGONISTS FOR THE TREATMENT OF CANCER  
The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a Notch receptor...
8841428 Polynucleotide nanomechanical device that acts as an artificial ribosome and translates DNA signals into polymer assembly instructions  
A polynucleic acid nanomechanical device with a linear array of alternating PX-JX2 devices and nucleic acid multi-crossover motifs that facilitate the assembly of a nucleic acid strand and...
8841322 Method for increasing the activity of lysosomal enzymes  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
US20140283217 Methods of Affecting Plant Growth With MicroRNA  
Provided herein are compositions and methods for producing transgenic plants. In specific embodiments, transgenic plants comprise a construct comprising a polynucleotide encoding microRNA167...
US20140274916 CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial...
US20140273209 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140273003 SUPER-RESOLUTION FLUORESCENCE LOCALIZATION MICROSCOPY  
The present invention relates generally ultrasensitive assays for use in diagnostics and in methods of drug screening and personalizing therapy for an individual patient. Specifically, the present...
8835835 Biomarkers of ionizing radiation  
The present invention provides novel radiation associated markers. The radiation associated markers may be one or more of albumin, LTGF-β, or any protein or peptide listed in any one of Tables 1, ...
8835619 Heat shock proteins from Mycobacterium leprae and uses thereof  
The present invention is directed to heat shock proteins from Mycobacterium leprae as well as their encoding polynucleotides and vectors and host cells containing these polynucleotides. These heat...
8835123 Methods for detecting progenitor cells and uses thereof  
Diagnostic and therapeutic methods pertaining to diseases and disorders of the breast, uterus and ovary are encompassed herein. More particularly, diagnostic methods for early detection of...
8833368 System and method for circuits to allow CPAP to provide zero pressure  
A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end,...
US20140256594 DNA PHOTOLITHOGRAPHY WITH CINNAMATE CROSSLINKERS  
The present invention relates generally to cinnamate crosslinkers. Specifically, the present invention relates to gels, biochips, and functionalized surfaces useful as probes, in assays, in gels,...
8828413 Peptoid oligomers, pharmaceutical compositions and methods of using the same  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions...
US20140244035 Manipulation of Objects  
A system for manipulation of objects. The system includes N objects, where N is greater than or equal to 2 and is an integer; and a mechanism for controlling and 2D locating of the N objects. A...
US20140243531 SUPERSTRUCTURES OF DIKETOPYRROLOPYRROLE DONORS AND PERYLENEDIIMIDE ACCEPTORS FORMED BY HYDROGEN-BONDING AND PI...PI STACKING  
A quantitative model that describes the assembly of diketopyrrolopyrrole-based donors and a perylenediimide acceptor into chiral superstructures, as a result of both hydrogen bonding and...
US20140243260 CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE  
The present invention relates to an isolated chimeric protein. The isolated chimeric protein includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion from...
8815327 Graded glass/zirconia/glass structures for damage resistant ceramic dental and orthopedic prostheses  
The present invention provides a functionally graded glass/ceramic/glass sandwich system for use in damage resistant, ceramic and orthopedic prosthesis. The functionally graded...
8815118 Lock and key colloids and methods of manufacture  
A method and system for assembling building blocks of colloidal particles and also for shaping of colloids for self-assembly for manufacturing, processing and formation of compositions of matter. A...
US20140233306 BIPOLAR SPIN-TRANSFER SWITCHING  
A magnetic device includes a magnetized polarizing layer, a free magnetic layer, and a reference layer. The free magnetic layer forms a first electrode and is separated from the magnetized...
8811706 System, method and computer accessible medium for providing real-time diffusional kurtosis imaging and for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging  
Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and...
US20140229164 APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR EXPLAINING CLASSIFICATIONS OF DOCUMENTS  
Classification of collections of items such as words, which are called “document classification,” and more specifically explaining a classification of a document, such as a web-page or website. Thi...
8806456 Configuration-preserving preprocessor and configuration-preserving parser  
Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for generating a plurality of tokens from one or more source files that include source code in a...
8802722 Benzopyran compounds as melanogenesis modifiers and uses thereof  
Provided are benzopyran compounds of formula I, for example, pomiferin-3′,4′-dimethyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pig...
8802660 De novo synthesis of glucocorticoids in the epidermis and its uses and applications  
The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions...
US20140221229 GENOMIC SIGNATURES OF METASTASIS IN PROSTATE CANCER  
A method of determining the risk of metastasis of prostate cancer in a human subject who has or had prostate cancer is disclosed herein. The method is based on detecting in a prostate sample from...
US20140220159 HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION  
The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
US20140220036 METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND FOR IDENTIFYING AGENTS USEFUL FOR TREATING NEURODEGENERATIVE DISEASES  
The present invention provides methods of inhibiting a tau protein such as h-tau42 or a biologically active fragment, derivative or analog thereof, methods of treating a disease caused by a tau...
8796449 s-Triazine compounds, pharmaceutical compositions and methods of using the same  
Novel s-triazine compounds are disclosed that have a formula represented by the following: L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as...
US20140212456 TREATMENT METHODS USING ATOXIC NEUROTOXIN DERIVATIVES  
The present invention relates to a treatment method. This method involves contacting a subject with an isolated, physiologically active, atoxic derivative of a Clostridial neurotoxin. Contacting is...
US20140212413 Methods of Treating TNF-alpha-Mediated Diseases Using Chimeric TNF-alpha Antibodies  
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pa...
8791985 Tracking and characterizing particles with holographic video microscopy  
In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the...
8791121 Oligooxopiperazines and methods of making and using them  
The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
US20140206718 Method of enhancing lysosomal alpha-Galactosidase A  
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.