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8183225 |
Inhibition of bone resorption using medical implants containing adenosine receptor antagonists
The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a...
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8183040 |
Methods for in vitro differentiation of Th-17+cells
The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be...
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8179577 |
Three-dimensional holographic ring traps
A method and system for preparing and using three dimensional optical ring traps. The method and system includes applying a single phase hologram to be able to independently control shape and force...
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US20120116688 |
METHOD, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR BASE-CALLING AND ALIGNMENT
Exemplary methods, procedures, computer-accessible medium, and systems for base-calling, aligning and polymorphism detection and analysis using raw output from a sequencing platform can be...
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US20120116524 |
EARLY INTERVENTION KNEE IMPLANT DEVICE AND METHODS
A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end...
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US20120114613 |
DEFINITIVE ENDODERM CELL POPULATIONS
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful...
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8174742 |
System for applying optical forces from phase gradients
A system and method for creating extended optical traps for applying optical forces to a material to be manipulated for a commercial application. The system and method include applying a hologram...
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8163748 |
s-Triazine compounds, pharmaceutical compositions and method of using the same
Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
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US20120095700 |
SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING MEMBRANE PROPERTIES RELATING TO DIFFUSION
Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a...
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US20120095328 |
SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR UTILIZING CARDIAC OUTPUT TO IMPROVE MEASUREMENT OF TRACER INPUT FUNCTION IN DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING
Exemplary embodiments of method, system and computer-accessible medium according to the present disclosure can be provided for converting magnetic resonance (MR) arterial signal intensity versus...
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8158380 |
Imaging agents for protein misfolding
Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using...
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8157868 |
Implants for the treatment of osteoarthritis of the knee
A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end...
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8153863 |
Transgenic plants expressing GLK1 and CCA1 having increased nitrogen assimilation capacity
Provided herein are compositions and methods for producing transgenic plants. In specific embodiments, transgenic plants comprise a construct comprising a polynucleotide encoding CCA1, GLK1 or...
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8142779 |
Treatment of follicular lymphomas using inhibitors of the LT pathway
Therapeutic uses of inhibitors of the lymphotoxin pathway to treat tumors, specifically to treat follicular lymphomas.
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8140269 |
Methods, computer-accessible medium, and systems for generating a genome wide haplotype sequence
Methods, computer-accessible medium, and systems for generating a genome wide probe map and/or a genome wide haplotype sequence are provided. In particular, a genome wide probe map can be generated...
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US20120066782 |
QUANTITATIVE ASSAY FOR MEMBRANE ASSOCIATION OF PROTEINS
The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a...
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US20120065094 |
METHODS AND KITS FOR DIAGNOSING OSTEOARTHRITIS AND PREDICTING PROGRESSION
This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.
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US20120064150 |
BIOCOMPATIBLE MATERIALS CONTAINING STABLE COMPLEXES OF TSG-6 AND HYALURONAN AND METHOD OF USING SAME
The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene 6 protein...
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US20120062220 |
AGGREGATED SPIN-TORQUE NANO-OSCILLATORS
A nano-oscillator magnetic wave propagation system has a group of aggregated spin-torque nano-oscillators (ASTNOs), which share a magnetic propagation material. Each of the group of ASTNOs is...
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8133471 |
CLK-peptide and SLK-peptide
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
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US20120058094 |
COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS BY CHARACTERIZING AND RESTORING MAMMALIAN BACTERIAL MICROBIOTA
The present invention relates to characterizing changes in mammalian intestinal microbiota associated with associated with high-fat and low-fat diets and with diets containing...
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8129341 |
Methods for treating diabetic wounds
The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application...
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8128907 |
CSF biomarker dilution factor corrections by MRI imaging and algorithm
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
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US20120053506 |
Apparatus and Method for Periodic Fluid-Delivery/Fluid-Removal Cycles in the Cranial Subarchnoid Space to Treat Cerebral Cortical Disorders
An apparatus for treating the brain comprises an implantable fluid exchange device coupled to a control unit to periodically alternate a delivery of a therapeutic agent with a removal of...
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US20120052505 |
METHODS FOR DETECTING EMBRYONIC STEM CELLS, INDUCED PLURIPOTENT STEM CELLS, OR CELLS UNDERGOING REPROGRAMMING TO PRODUCE INDUCED PLURIPOTENT STEM CELLS
The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem...
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8124581 |
Methods for treating breast cancer using NRIF3 related molecules
Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis...
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8119421 |
Methods to identify compounds useful for the treatment of proliferative and differentiative disorders
The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention...
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US20120041727 |
METHOD, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEMS FOR SCORE-DRIVEN WHOLE-GENOME SHOTGUN SEQUENCE ASSEMBLE
Exemplary embodiments of the present disclosure relate generally to methods, computer-accessible medium and systems for assembling haplotype and/or genotype sequences of at least one genome, which...
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US20120041175 |
NOVEL AUTOGRAPHY REGULATORS ATG14L AND RUBICON
The present invention provides for up- and down-regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel...
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US20120040992 |
OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
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8112417 |
Method and system for data classification in the presence of a temporal non-stationarity
A method and system for determining a feature of a particular pattern are provided. In particular, data records are received, and predetermined patterns that are associated with at least some of...
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8110181 |
Method of treating tuberculosis with interferons
A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Al...
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US20120029331 |
IDENTIFICATION, DIAGNOSIS, AND TREATMENT OF NEUROPATHOLOGIES, NEUROTOXICITIES, TUMORS, AND BRAIN AND SPINAL CORD INJURIES USING ELECTRODES WITH MICROVOLTAMMETRY
The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a...
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US20120028369 |
QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the...
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8105572 |
Method of treating tuberculosis with interferons
A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Fu...
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8105571 |
Method of treating pulmonary disease with interferons
A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon...
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US20120021002 |
GENETICALLY ENGINEERED CLOSTRIDIAL GENES, PROTEINS ENCODED BY THE ENGINEERED GENES, AND USES THEREOF
The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide...
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8103611 |
Architectures, systems, apparatus, methods, and computer-readable medium for providing recommendations to users and applications using multidimensional data
Exemplary non-transitory computer-readable medium, method and system for providing at least one recommendation to users and applications using multidimensional data. The multidimensional data can...
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US20120010519 |
System and Method for Diagnosis and Treatment of Obstructive Sleep Apnea
A system for diagnosis and treatment of breathing disorders in a patient, comprises a flow generator supplying an air flow to an airway of a patient via a flow path, a venting arrangement moveable...
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8094318 |
Method and apparatus for determining reflectance data of a subject
An apparatus for obtaining reflectance data of an object includes a diffuser having a surface. The apparatus includes a mapping portion that affects a mapping between a light field at the object's...
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8093365 |
Biocompatible materials containing stable complexes method of TSG-6 and hyaluronan and method of using same
The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein...
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8093043 |
β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
The invention relates to modulating BimEL levels (Bcl-2-Interacting Mediator of cell death, Extra Long isoform) to sensitize cancer cells to cell death or apoptosis. In certain embodiments, the...
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8093021 |
Defective sindbis viral vectors
Disclosed herein are new defective Sindbis viral vectors made from a novel Helper plasmid, with differences in envelope proteins between JT vectors and consensus Sindbis virus sequences, and also...
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US20120004498 |
DEVICE AND METHOD FOR REDUCING TENSION AND STRESS IN A SUBJECT
The present invention relates to a sensory device for reducing tension in a subject. The device includes an elastic covering, a filling material inside the elastic covering, an openable sealed...
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US20120002851 |
System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging
Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and...
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US20120000466 |
System and Method for Improved Treatment of Sleeping Disorders using Therapeutic Positive Airway Pressure
Described is a method and system providing therapeutic positive airway pressure to a particular area of patient's airways. The system may include a flow generator and a processing arrangement. The...
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8090747 |
Method, system, computer-accessible medium and software arrangement for organization and analysis of multiple sets of data
Exemplary embodiments of system, computer-accessible medium and method can be provided for organizing or analyzing at least two sets of data. The sets of data can be organized and/or analyzed by...
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US20110318430 |
TUMOR THERAPY WITH ANTITUMOR AGENTS IN COMBINATION WITH SINDBIS VIRUS-BASED VECTORS
A method for treating malignant tumors with Sindbis viral based vectors in combination with antitumor agents and pharmaceutical formulations for use in such treatment.
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US20110318358 |
IMMUNOTHERAPY FOR CLEARING PATHOLOGICAL TAU CONFORMERS
The present invention relates to methods of treating and preventing Alzheimer's Disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies...
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8076309 |
USP47 inhibtors and methods to induce apoptosis
The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates...
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