Patents and Patent Applications from Mount Sinai School of Medicine of NYU


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9719067 Generation of anterior foregut endoderm from pluripotent cells  
The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such...
9597377 Stable formulations of purified proteins  
This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and...
US20170051348 POOLED ADAPTER STRATEGY FOR REDUCING BIAS IN SMALL RNA CHARACTERIZATION  
Modified nucleic acid adapters are provided that collectively provide a mixture of nucleotides at the 3′ end of 5′ adapters and at the 5′ end of 3′ adapters such that at least one adapter in each...
US20160375056 METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS  
The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a...
9487825 Pooled adapter strategy for reducing bias in small RNA characterization  
Modified nucleic acid adapters are provided that collectively provide a mixture of nucleotides at the 3′ end of 5′ adapters and at the 5′ end of 3′ adapters such that at least one adapter in each...
US20160168535 GENERATION OF ANTERIOR FOREGUT ENDODERM FROM PLURIPOTENT CELLS  
The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such...
US20160113962 GROWTH CONTROL OF ORAL AND SUPERFICIAL ORGANISMS USING GALLIUM COMPOUNDS  
The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a...
9321772 Substituted pyrazolo[3,4-D]pyrimidines and uses thereof  
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
9303044 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders  
The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B,...
US20160068823 CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF  
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses...
9249190 Method of suppressing gene transcription through histone lysine methylation  
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a...
9234170 Generation of anterior foregut endoderm from pluripotent cells  
The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such...
US20150352148 METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS  
The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a...
US20150299700 EMBEDDED CHIMERIC PEPTIDE NUCLEIC ACIDS AND USES THEREOF  
The present invention relates to an ecPNA having the general structure: H2N—X—B—Y—COOH and uses thereof, wherein X is A or C and Y is A or C with the proviso that when X is A, Y is C, and when X...
US20150258129 Method for Increasing the Activity of Lysosomal Enzymes  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
9062122 Targeting the Rosa26 gene in human embryonic stem cells  
The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the...
US20150132330 INFLUENZA VIRUS VACCINES AND USES THEREOF  
Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising modified glycosylation sites and...
US20150064284 METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS  
The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a...
8961962 Acid ceramidase and mammalian cell survival  
The present invention relates to methods of promoting the survival of cells by treating the cells with acid ceramidase. A kit for promoting ex vivo cell survival is also disclosed, as is a method...
US20150017649 COMPOSITIONS AND METHODS FOR DETECTING NOONAN SYNDROME  
Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange...
8895077 Methods for preventing or treating infectious diseases caused by extracellular microorganisms, including antimicrobial-resistant strains thereof, using gallium compounds  
The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a...
US20140328758 USE OF FSH RECEPTOR LIGANDS FOR DIAGNOSIS AND THERAPY OF CANCER  
The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed...
US20140287494 MESENDODERM AND MESODERM CELL POPULATIONS  
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are...
US20140287015 CERAMIDASE AND CELL DIFFERENTIATION  
The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated...
8841322 Method for increasing the activity of lysosomal enzymes  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
US20140273209 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140243357 SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF  
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
8808992 SHOC2 mutations causing noonan-like syndrome with loose anagen hair  
The present invention is directed to methods of diagnosing Noonan-like syndrome with loose anagen hair comprising detecting a mutation in SHOC2 gene. One specific diagnostic mutation disclosed is...
US20140213578 TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS  
Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and...
US20140206718 Method of enhancing lysosomal alpha-Galactosidase A  
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.
8784776 Use of FSH receptor ligands for diagnosis and therapy of cancer  
The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed...
US20140193520 GROWTH CONTROL OF ORAL AND SUPERFICIAL ORGANISMS USING GALLIUM COMPOUNDS  
The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a...
US20140178307 METHODS AND ASSAYS FOR TREATING SUBJECTS WITH SHANK3 DELETION, MUTATION OR REDUCED EXPRESSION  
Methods and assays are disclosed for treating subjects with 22q13 deletion syndrome or SHANK3 deletion or duplication, mutation or reduced expression, where the methods comprise administering to...
US20140170163 MONOCLONAL ANTIBODIES AGAINST INFLUENZA VIRUS GENERATED BY CYCLICAL ADMINISTRATION AND USES THEREOF  
Provided herein are methods of producing neutralizing monoclonal antibodies, by cyclical immunization, that cross-react with strains of Influenza virus of the same subtype or different subtypes....
8748171 Cell population enriched for endoderm cells  
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are...
8722402 Artificial immune system: methods of use  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140113006 METHODS OF DETERMINING WHETHER THE WNT SIGNALING PATHWAY IS UPREGULATED IN A TUMOR  
The invention demonstrates that canonical Wnt signaling is activated in certain primary tumors and tumor cell lines in the absence of ?-catenin or APC mutations and that inhibition of such...
8703503 Methods and compositions for inhibition of BCL6 repression  
Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods or blocking corepressor binding to the BCL6 lateral groove. Additionally,...
8691762 Methods and assays for treating subjects with SHANK3 deletion, mutation or reduced expression  
Methods and assays are disclosed for treating subjects with 22q13 deletion syndrome or SHANK3 deletion or duplication, mutation or reduced expression, where the methods comprise administering to...
US20140086869 METHODS AND COMPOSITIONS FOR TREATING TUMORS USING MYELOID DERIVED SUPPRESSOR CELLS  
Compositions and methods for diagnosing and treating tumors using myeloid derived suppressor cells (MDSCs) are provided. More particularly, the compositions contain labeled MDSCs or MDSCs in...
8673314 Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof  
Provided herein are methods of producing neutralizing monoclonal antibodies, by cyclical immunization, that cross-react with strains of Influenza virus of the same subtype or different subtypes....
US20140072969 Differential Diagnosis Of Cancer And Other Conditions Based On Expression Of p63  
This invention relates to methods of distinguishing among various types of differentiated and undifferentiated epithelial carcinomas, and non-epithelial carcinomas, by detecting the presence of...
US20140051725 Method For Increasing The Activity Of Lysosomal Enzymes  
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
US20140046226 REHABILITATIVE TRAINING DEVICES FOR USE BY STROKE PATIENTS  
According to one embodiment, a rehabilitative training device for use with a stroke patient includes a first component that is operatively coupled to a first body part (unaffected body part) of...
US20140045797 Bisphosphonate-Prostatic Acid Phosphatase Inhibitor Conjugates To Treat Prostate Cancer Bone Metastasis  
The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for...
US20140044678 CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF  
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses...
8633221 Method of enhancing lysosomal α-galactosidase A  
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.
8591881 Chimeric Newcastle disease viruses and uses thereof  
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses...
US20130287739 SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE  
The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.
8568980 Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia  
The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates...