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US20120130164 |
MAGNETIC BASED DEVICE FOR RETRIEVING A MISPLACED ARTICLE
A device for locating and retrieving a misplaced foreign body that has metallic characteristics includes a shaft connected to a handle and a retrieval tool that is coupled to the shaft and moves...
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US20120115158 |
METHOD TO DETERMINE EMBRYO AND OOCYTE QUALITY BASED ON CERAMIDASE
The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells,...
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US20120114613 |
DEFINITIVE ENDODERM CELL POPULATIONS
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful...
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8158605 |
Azacytidine analogues and uses thereof
The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O);R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of...
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US20120082688 |
In Vitro Generation of Myeloid Derived Suppressor Cells
The invention relates to methods of isolating, culturing, and differentiating myeloid derived suppressor cells (MD-SCs) from embryonic stem (ES) cells and hematopoietic stem cells (HSCs). In...
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8137676 |
Genetically engineered equine influenza virus and uses thereof
The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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8124101 |
Genetically engineered swine influenza virus and uses thereof
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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US20120041175 |
NOVEL AUTOGRAPHY REGULATORS ATG14L AND RUBICON
The present invention provides for up- and down-regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel...
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US20120039841 |
T-Helper Cell Type 17 Lineage-Specific Adjuvants, Compositions and Methods
The present invention relates to compositions and methods for the modulation of TN 17 responses. The invention provides compositions for the induction of TN 17 responses containing a TLR agonist...
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US20120037165 |
SPINAL SHIELD IMPLANT AND TREATMENT OF SPINAL METASTASES
A radiation shield for use in treating spinal metastatic disease is formed of a body that is configured to surround the spinal cord and includes a section that can be axially extended for...
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US20120028912 |
Methods of modulating bromodomains
The present invention features compounds useful for and methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods for treating HIV infection...
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8106033 |
Composition and methods for the treatment of proliferative diseases
Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group...
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8097283 |
Methods and compositions for imaging
The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at...
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8057803 |
Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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US20110275955 |
TISSUE SAMPLING TOOL
A sampling tool for isolating and collecting a tissue biopsy includes a hollow sampling cylinder that includes a first end and an opposing second end. The first end being a sharpened, annular...
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US20110256101 |
SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE
The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.
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8030013 |
Methods and compositions for the diagnosis for early hepatocellular carcinoma
Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A,...
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8012490 |
Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents
The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by...
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US20110212061 |
Mesoderm and Definitive Endoderm Cell Populations
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful...
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US20110189266 |
CORTICOSTEROID MICROVESICLES FOR TREATMENT OF CARDIOVASCULAR DISEASES
The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle-forming phospholipids, and a corticosteroid in water soluble...
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7960128 |
TRP8, a transient receptor potential channel expressed in taste receptor cells
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells...
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7960127 |
TRP8, a transient receptor potential channel expressed in taste receptor cells
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells...
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7955849 |
Method of enriching a mammalian cell population for mesoderm cells
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful...
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US20110123511 |
Method of Suppressing Gene Transcription Through Histone Lysine Methylation
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a...
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7947460 |
Method for diagnosis and therapy of hazelnut-induced systemic reaction
The present invention is directed to methods for predicting or diagnosing a hazelnut-induced systemic reaction, and for methods for treating such a reaction.
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7947307 |
Methods and compositions for imaging
The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical...
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7939057 |
Methods and compositions for modulating the mobilization of stem cells
Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral...
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US20110105423 |
COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUS REPLICATION AND USES THEREOF
The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention...
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7935525 |
Inhibition of ATF2 activity to treat cancer
The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation,...
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US20110088695 |
PROTECTIVE SHEATH FOR USE WITH VENTILATION BAG
In accordance with one embodiment of the present invention, a protective sheath for use with a manual ventilation bag that is associated with an anesthesia apparatus includes a sheath body that is...
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7919276 |
ZA loops of bromodomains
The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides a binding partner for the bromodomain. In addition,...
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US20110076765 |
METHOD FOR INCREASING THE ACTIVITY OF LYSOSOMAL ENZYMES
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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US20110071443 |
REHABILITATIVE TRAINING DEVICES FOR USE BY STROKE PATIENTS
According to one embodiment, a rehabilitative training device for use with a stroke patient includes a first component that is operatively coupled to a first body part (unaffected body part) of the...
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US20110071043 |
Methods For Characterizing Antibody Binding Affinity And Epitope Diversity in Food Allergy
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects,...
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US20110070203 |
MESENDODERM AND MESODERM CELL POPULATIONS
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful...
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US20110065672 |
BISPHOSPHONATE-PROSTATIC ACID PHOSPHATASE INHIBITOR CONJUGATES TO TREAT PROSTATE CANCER BONE METASTASIS
The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for...
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US20110059899 |
Kruppel-like factor 6 (KLF6), a tumor suppressor protein, and diagnostics, therapeutics, and screening based on this protein
The present invention relates to identification of tumor suppressor activity of a protein, KLF6 (KLF6), and to related diagnostic and therapeutic compositions and methods. The discovery of this...
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US20110059851 |
SHOC2 Mutations Causing Noonan-Like Syndrome With Loose Anagen Hair
The present invention is directed to methods of diagnosing Noonan-like syndrome with loose anagen hair comprising detecting a mutation in SHOC2 gene. One specific diagnostic mutation disclosed is...
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7888066 |
Methods for identifying substances for the treatment of Alzheimer's disease
The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also...
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7884067 |
Peptides derived from cadherin and methods of use thereof
The present invention provides polypeptides and peptides derived from cadherin. The polypeptides and peptides are useful in a method of inhibiting amyloid deposition and a method of inhibiting...
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7879977 |
Methods and reagents for decreasing clinical reaction to allergy
It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T cell) binding sites, can be modified to be less allergenic by modifying the IgE binding sites....
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US20110022355 |
Network Characterization, Feature Extraction and Application to Classification
Methods, systems and apparatus for characterizing networks are presented. For example, a method of characterizing a network represented by a plurality of nodes and a plurality of edges is provided....
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US20110020802 |
NUCLEIC ACIDS, METHODS AND KITS FOR THE DIAGNOSIS OF DYT6 PRIMARY TORSION DYSTONIA
The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to...
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US20100316572 |
USE OF FSH RECEPTOR LIGANDS FOR DIAGNOSIS AND THERAPY OF CANCER
The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed...
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US20100310451 |
ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a...
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7833774 |
Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such...
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7812033 |
Method for increasing the activity of acid-β-galactosidase
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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US20100249184 |
INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION
The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound...
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7803982 |
T1R3 transgenic animals, cells and related methods
The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with...
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7799326 |
Methods and compositions for cathespin k complex-mediated disorders
Methods and compositions for the amelioration of symptoms mediated by the collagenolytic activity of cathepsin K complex are provided. Methods of specifically modulating the collagenolytic activity...
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