Patents and Patent Applications from Medical University of South Carolina


Matches 1 - 50 out of 99 1 2 >
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9775930 Composition for modifying myocardial infarction expansion  
A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the...
US20170258961 COMPOSITION FOR MODIFYING MYOCARDIAL INFARCTION EXPANSION  
A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the...
9676738 Antifibrotic effects of oxetanyl sulfoxides  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and...
US20170107190 ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and...
US20150226685 SYSTEMS AND METHODS FOR QUANTIFYING MULTIPLE REFRACTIONS WITH DIFFRACTION ENHANCED IMAGING  
Systems and methods for detecting small angular changes in an X-ray beam caused by multiple refractions within an object. According to an aspect, a method for detecting an image of an object...
US20150203916 PLASMA ANALYTES PREDICT DIAGNOSIS AND PROGNOSIS OF THORACIC AORTIC ANEURYSM  
Disclosed are methods and materials for assessing thoracic aortic aneurysm using a combination of protein and microRNA biomarkers. The presence or levels of the biomarkers can be measured in a...
9005672 Methods of modifying myocardial infarction expansion  
A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the...
US20150017265 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION  
A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the...
8852932 Self-assembling cell aggregates and methods of making engineered tissue using the same  
A method of making engineered tissue from a plurality of cell aggregates is disclosed. A cell suspension is centrifuged. The resulting pellet is extruded through an orifice, and the extruded...
US20140274950 PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
8815556 Compositions and methods for tissue engineering, tissue regeneration and wound healing  
In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel...
US20130344588 DEVICES AND METHODS FOR CONCENTRATION AND ANALYSIS OF FLUIDS  
Disclosed are articles, compositions and methods for detecting analytes. The disclosed articled, compositions and methods increase the ease of detection and quantitation of the target analyte.
US20130338194 Predicting Atrial Fibrillation Recurrence by Protease and Protease Inhibitor Profiling  
Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling.
US20130289141 Assessing Cardiac Disease Via Detection and Measurement of MicroRNA  
Disclosed are methods and materials for assessing cardiac disease, including cardiac failure, cardiac hypertrophy, thoracic aortic aneurysm, left ventricular remodeling using microRNA levels. The...
US20130237439 SYSTEMS AND METHODS USING BIOMARKER PANEL DATA  
Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, the...
US20130236504 Delivery System for Enhancing Drug Efficacy  
Disclosed are delivery systems that can be used for treating cancer. The delivery systems include a delivery vehicle in conjunction with a chemo-adjuvant. The chemo-adjuvant can enhance the...
US20130236431 Compositions and Methods for Tissue Engineering, Tissue Regeneration and Wound Healing  
In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel...
US20130196870 SYSTEMS AND METHODS USING BIOMARKER PANEL DATA  
Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data and related medical devices and methods, amongst other things. An embodiment can include a...
US20130171236 Prevention and Treatment of Ischemia-Reperfusion Injury and Related Conditions  
Disclosed are lipids, annexin, and lipid-annexin complexes for use in the prevention and/or treatment of ischemia-reperfusion injury and reperfusion injury associated with a variety of diseases...
8409603 Compositions and methods for tissue engineering, tissue regeneration and wound healing  
In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel...
US20120245201 Isopropylphenidate for Treatment of Attention-Deficit/Hyperactivity Disorder and Fatigue-Related Disorders and Conditions  
The present invention relates to the identification of isopropylphenidate as a useful therapeutic agent in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) as well as various...
US20120220548 Compositions and methods for treatment of virus-associated cancer cells  
Compositions, methods and kits are provided for treating a cancer, tumor or pre-cancerous tissue condition resistant to a chemotherapeutic agent, the tissue condition having one or more proteins...
US20120046232 COMPOSITIONS AND METHODS FOR REDUCING RELAPSE OF ADDICTIVE BEHAVIOR  
Disclosed are methods and compositions comprising mGluR modulators and procysteine drugs. The methods and compositions can be used to treat subjects with prior addiction in order to reduce drug...
US20120035268 SPHINGO-GUANIDINES AND THEIR USE AS INHIBITORS OF SPHINGOSINE KINASE  
The presently disclosed subject matter provides compounds of the formula: (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also...
US20110306089 THERMOPHILIC METHANOGENIC CONSORTIUM FOR CONVERSION OF CELLULOSIC BIOMASS TO BIOENERGY  
A system for the efficient conversion of plant biomass to methane is provided, where the conversion includes use of a thermophilic methanogenic consortium containing a cellulolytic thermophile, an...
8058227 Method of treating fibrosis in a subject in need thereof comprising administering a composition comprising a CSD  
Disclosed are compositions and methods for the treatment of fibrosis. Also disclosed are methods of screening for agents that treat fibrosis.
US20110263664 Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer  
The disclosure relates to inhibitors of Pim-1 and/or Pim-2 protein kinase, to compositions comprising one or more inhibitors of Pim-1 and/or Pim-2 protein kinase, and to methods for treating cancer.
US20110236403 TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
US20110178162 TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
US20110177100 TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
US20110177075 TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
US20110086068 Compositions and Methods for Tissue Engineering, Tissue Regeneration and Wound Healing  
In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel...
US20110077503 Automatic MRI Quantification of Structural Body Abnormalities  
Disclosed herein are methods and systems related to the body region analysis. In some forms, the analysis relates to body region abnormalities. In some forms, the methods and systems analyze and...
US20110034559 Cell Repair And Regeneration By Suramin And Related Polysulfonated Naphthylureas  
Disclosed herein are compositions and methods for promoting the repair and regeneration of injured tissues, such as injuries resulting from ischemic damage. Also disclosed are compositions and...
US20110034419 Cardioprotective Drugs and Diagnostics for Assessing Risk of Cardiovascular Disease  
Disclosed are methods of diagnosing cardiovascular disease comprising measuring sphingolipids. Also disclosed are methods of predicting cardiovascular disease comprising measuring sphingolipids....
US20110033516 METHODS AND COMPOSITIONS FOR BONE HEALING BY PERIOSTIN  
The present invention provides methods and compositions for increasing bone production and/or decreasing bone fracture healing time in a subject, by administering an effective amount of periostin...
US20100297627 MicroRNA Diagnostics for Cancer  
Disclosed are methods for detecting breast cancer or prostate cancer by measuring levels of miR-204 and miR-510 in samples.
US20100286762 Compositions and Methods for Ameliorating Clinical Electrical Disturbances  
Disclosed are compositions and methods for the use of ACT1 peptide or other approaches to targeting the ZO-1 PDZ2 domain to treat non-injury related disturbance to electrical activation and ion...
US20100130432 Non-Natural Amino Acids and Neurotensin Analogues Thereof  
This invention relates to non-natural desamino amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin...
US20100113863 Methods and Systems for Using Transcranial Magnetic Stimulation to Enhance Cognitive Performance  
Methods and systems are provided for using transcranial magnetic stimulation (TMS) to enhance cognitive performance of at least one subject. At least one neural circuit is located in the brain of...
US20090292306 Inflatable Gastric Device and Methods Relating to the Same  
In accordance with certain embodiments of the present disclosure, a device for treatment of obesity in a patient is provided. The device comprises an inflatable material and a flexible ring-shaped...
US20090075875 PROTECTION AGAINST LUNG FIBROSIS BY UP-REGULATING THE FUNCTION OR EXPRESSION OF CAVEOLIN-1  
Disclosed are compositions and methods for the treatment of fibrosis. Also disclosed are methods of screening for agents that treat fibrosis.
US20090022817 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION  
A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the...
US20090017512 APPARATUS AND METHODS FOR THE PRODUCTION OF ETHANOL, HYDROGEN AND ELECTRICITY  
The compositions, methods and apparatus of the present invention allow the production of electricity, ethanol and hydrogen, and combinations thereof. In some embodiments, the invention provides a...
7462480 Stimulation of microbial dechlorination of polychorinated biphenyls with halogenated ethenes  
Disclosed is a method for the anaerobic microbial dechlorination of polychlorinated biphenyls (PCBs). Polyhalogenated ethenes are used to stimulate the growth and dechlorinating activity of PCB...
US20080227846 METHODS OF TREATING JUVENILE TYPE 1 DIABETES MELLITUS  
The present disclosure describes methods for treating or preventing Type 1 diabetes mellitus in juveniles, particularly in juveniles newly diagnosed with Type 1 diabetes. This prevention or...
7396659 Inhibitors of nitric oxide synthase to treat type 1 diabetes  
A method for treating type 1 diabetes in a human in need of such treatment, comprising administering to the human a biologically effective amount of at least one inhibitor of inducible nitric...
US20070185566 INTRAVASCULAR MEDICAL DEVICE  
An intravascular device comprises an inflatable member, a non-porous membrane and a lumen. The inflatable member defines a conduit therein and the inflatable member is moveable about and between a...
US20070027094 Inhibitors of nitric oxide synthase  
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory...
US20060234910 Methods for the treatment of insulin resistance and disease states characterized by insulin resistance  
The MINOR and TR3 genes are disclosed to be insulin responsive genes differentially expressed as a function of insulin resistance and Type 2 Diabetes in humans and a variety of well characterized...
Matches 1 - 50 out of 99 1 2 >