Patents and Patent Applications from Medical College of Wisconsin Research Foundation


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US20170300622 SYSTEMS AND METHODS FOR ESTIMATING HISTOLOGICAL FEATURES FROM MEDICAL IMAGES USING A TRAINED MODEL  
Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of...
US20170281737 UNIVERSAL PLATFORM FOR TARGETING THERAPIES TO TREAT NEUROLOGICAL DISEASES  
The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment,...
9778272 Methods and kits for measuring von Willebrand factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
US20170276691 Methods and Kits for Measuring Von Willebrand Factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
US20170275313 MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF  
The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
9720253 Method and apparatus for limiting growth of eye length  
Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the...
US20170185072 SYSTEM AND METHOD FOR FABRICATING ELECTROMAGNETIC FIELD ENHANCING OBJECTS FOR MAGNETIC RESONANCE IMAGING  
Systems and methods for designing and fabricating three-dimensional objects with precisely computed material compositions for use in enhancing electromagnetic fields for magnetic resonance imaging...
9678089 Methods and kits for measuring von Willebrand factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
US20170114411 HIGHLY SENSITIVE TRANSPLANT REJECTION SURVEILLANCE USING TARGETED DETECTION OF DONOR SPECIFIC CELL FREE DNA  
Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
US20170106006 Neuroprotection by Mitochondria-Targeted Metformin  
The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide...
US20170080055 Hematopoitetic Growth Factor Proteins and Analogs Thereof and Angiotensin Converting Enzyme Inhibitors for Treatment of Radiation Exposure  
Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute...
US20170056021 Detection and Treatment of Abnormal Upper Esophageal Sphincter Functionality  
An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal...
US20170044627 Six-Gene Biomarker of Survival and Response to Platinum Based Chemotherapy in Serious Ovarian Cancer Patients  
Described herein are methods of predicting the risk of developing ovarian cancer recurrence of a subject comprising the steps of detecting the expression levels of at least four of the six genes...
9526449 Detection and treatment of abnormal esophageal sphincter functionality  
An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal...
US20160364466 METHODS AND APPARATUS FOR ENHANCED DATA STORAGE BASED ON ANALYSIS OF DATA TYPE AND DOMAIN  
In some embodiments, an apparatus includes a data management module implemented in at least one of a memory or a processor. The data management module is configured to associate a different...
9511072 Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases  
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE...
US20160340642 METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS  
Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell...
US20160333083 TARGETING CLPTM1L FOR TREATMENT AND PREVENTION OF CANCER  
Provided herein are therapeutic agents having specificity for human CLPTM1 L polypeptide, including therapeutic agents comprising one or more CLPTM1 L-targeting agents, compositions comprising...
US20160310761 ADAPTIVE REPLANNING BASED ON MULTIMODALITY IMAGING  
Systems and methods directed to adaptive radiotherapy planning are provided. In some aspects, provided system and method include producing synthetic images from magnetic resonance data using...
9427147 Directional optical coherence tomography systems and methods  
An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence...
9422318 Epoxyeicosatrienoic acid analogs and methods of making and using the same  
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension...
9414766 Method for simultaneous multi-slice magnetic resonance imaging using single and multiple channel receiver coils  
A method for reconstructing a plurality of images depicting a subject from image data that is simultaneously acquired from a corresponding plurality of slice locations with a magnetic resonance...
US20160229900 ENGINEERED CXCL12 ALPHA LOCKED DIMER POLYPEPTIDE  
The present invention provides a novel CXCL12-α2 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders,...
US20160222121 METHODS FOR TREATING HEMATOLOGIC CANCERS  
The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA-4. In one embodiment, an inhibitor of PD-1 or...
US20160166205 MOTION TRACKING SYSTEM FOR REAL TIME ADAPTIVE IMAGING AND SPECTROSCOPY  
This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is...
9346871 Engineered CXCL12 alpha locked dimer polypeptide  
The present invention provides a novel CXCL12-α2 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders,...
US20160095605 COMPRESSION DEVICE AND PRESSURE SENSOR FOR TREATMENT OF ABNORMAL UPPER ESOPHAGEAL SPHINCTER FUNCTIONALITY  
A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter...
9265789 Targeting CLPTM1L by RNA interference for treatment and prevention of cancer  
Provided herein are compositions for reducing CLPTM1L expression in a cell as well as methods for using such compositions to treat or prevent cancer in a subject. In particular, compositions...
US20150361152 MONOMERIC CXCL121 PEPTIDE AND METHODS OF SYNTHESIS AND USE THEREOF  
The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and...
9198595 Reagents and methods for modulating cone photoreceptor activity  
The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.
US20150336916 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME  
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension...
US20150293200 Methods for Generating Imaging Biomarkers Based on Diffusion Tensor Imaging of the Spinal Cord  
Systems and methods for producing imaging biomarkers that indicate a tissue state in the nervous system of a subject based on diffusion tensor imaging (“DTI”) of the subject's spinal cord or brain...
9138175 Motion tracking system for real time adaptive imaging and spectroscopy  
This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is...
9127027 Epoxyeicosatrienoic acid analogs and methods of making and using the same  
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension...
US20150227793 MOTION TRACKING SYSTEM FOR REAL TIME ADAPTIVE IMAGING AND SPECTROSCOPY  
This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is...
US20150219677 Methods and Kits for Measuring Von Willebrand Factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
9076212 Motion tracking system for real time adaptive imaging and spectroscopy  
This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is...
US20150185214 METHODS AND KITS FOR MEASURING VON WILLEBRAND FACTOR  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
US20150160313 SYSTEM AND METHOD FOR DIRECT RADIO FREQUENCY PHASE CONTROL IN MAGNETIC RESONANCE IMAGING  
Described here are systems and methods for improved magnetic resonance imaging (“MRI”} using a radio frequency (“RF”} system that establishes a Larmor frequency using a clock signal generated by...
9046535 Methods and kits for measuring von willebrand factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having...
US20150137811 SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGING USING HIGHLY ACCELERATED PROJECTION IMAGING  
A method for highly accelerated projection imaging (“HAPI”) is provided. In this method, conventional linear gradients are used to obtain coil sensitivity-weighted projections of the object being...
US20150086477 HIGHLY SENSITIVE SURVEILLANCE USING DETECTION OF CELL FREE DNA  
Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
D724225 Compression device  
8962600 Neuroprotective compounds and their use  
Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.
8937039 Peptide-based peroxidase inhibitors and methods of using same  
The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox...
US20150015846 Directional Optical Coherence Tomography Systems and Methods  
An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence...
US20140371723 Rapid Access Vitreal Injection Guide  
Embodiments of the invention provide an injection guide for stabilizing an injection site located on an ocular structure during an intravitreal injection. The injection guide includes a first...
US20140329811 Methods of Modulating Cell Proliferation and Cyst Formation in Polycystic Kidney and Liver Diseases  
The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE...
US20140324400 Gesture-Based Visualization System for Biomedical Imaging and Scientific Datasets  
Three-dimensional visualization of biomedical datasets in an immersive visual environment includes creating a finite element mesh patient specific three-dimensional mode. Points from the finite...
US20140314750 Six-Gene Biomarker of Survival and Response to Platinum Based Chemotherapy in Serious Ovarian Cancer Patients  
Described herein are methods of predicting the risk of developing ovarian cancer recurrence of a subject comprising the steps of detecting the expression levels of at least four of the six genes...
Matches 1 - 50 out of 176 1 2 3 4 >