Patents: Medical College of Georgia Research Institute

Patents and Patent Applications from Medical College of Georgia Research Institute

Matches 1 - 50 out of 101

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Match	Document	Document Title
1	US20120115785	ENDOTHELIAL NITRIC OXIDE SYNTHASE ANTAGONISTS AND USES THEREOF FOR INHIBITING OXYGEN TOXICITY Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a ...
2	8169216	System and method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces A method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces is disclosed. The method includes the steps of scanning a test object having a plurality of anisotropic...
3	8134363	Test object for use with diffusion MRI and system and method of synthesizing complex diffusive geometries using novel gradient directions A test object for use with diffusion MRI and a system and methods of synthesizing complex diffusive geometries. The test object, which includes anisotropic structures, can be used to monitor DTI...
4	8098068	Systems and methods for parametric mapping for correction of noise-based systematic bias of DTI metrics, using a DTI mapping phantom A system and method for minimizing, if not completely eliminating, the systematic bias present in an MR system used for DTI is disclosed. A test object or “phantom” of the present invention is sca...
5	US20120009271	METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present...
6	US20110305713	METHODS AND COMPOSITIONS TO ENHANCE VACCINE EFFICACY BY REPROGRAMMING REGULATORY T CELLS The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining LNs, where it can potently activate Foxp3 regulatory T...
7	US20110300241	ORAL CARE COMPOSITIONS FOR TREATING XEROSTOMIA Disclosed herein are oral care compositions for promoting salivary flow. Thus, also disclosed are methods of treating and preventing xerostomia. The oral care compositions can contain all-natural...
8	US20110268710	METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of...
9	US20110245339	PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB0,+ are provided. The...
10	7994784	Systems and methods for rescaling image intensities with diffusion MRI to synthesize complex diffusive geometries A method for scaling MR signal intensity after noise has been removed is disclosed. Because the signal in a DTI series varies with the apparent diffusivity in the direction of an applied gradient,...
11	US20110136894	Shortened Alk1 Regulatory Fragment Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or 100%...
12	US20110135672	HLA-G COMPOSITIONS AND METHODS OF USE THEREOF It has been discovered that HLA-G dimers are potent ligands of ILT2 and ILT4 on immune cells and enhance signal transduction through ILT2 and ILT4. Enhanced signal transduction through ILT-2, ILT-4...
13	US20110135572	COMPOSITIONS AND METHODS FOR DIAGNOSING LATE-ONSET ALZHEIMER'S DISEASE Genetic markers for late-onset Alzheimer's disease (AD) within the TRPC4AP gene locus are provided. The genetic markers include single nucleotide polymorphisms (SNPs) and haplotypes. Methods and...
14	US20110131669	GANGLIOSIDE EPITOPES FOR TREATING GUILLAIN-BARRE SYNDROME Disclosed are compositions and methods for treating Guillain-Barré syndrome (GBS) in a subject that involves neutralizing specific pathogenic anti-glycolipid antibodies in the circulation of the ...
15	US20110124720	COMPOSITIONS AND METHODS FOR TREATING IMMUNE DISORDERS Green tea polyphenol compositions and methods of their use are provided. Certain aspects provide methods for modulating expression of one or more autoantigens using the disclosed green tea...
16	US20110123590	Selective Expansion of Regulatory T Cells Methods for expanding regulatory T cells in vitro are provided. It has been discovered that regulatory T cells can be expanded in vitro by culturing a mixed population of lymphocytes on planar cell...
17	7938643	Use of integrating sphere technology to provide uniform, high-intensity light, and wavelength mixing from light emitting diodes An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be...
18	US20110047631	HEAT SHOCK PROTEIN DEFICIENCIES AS MODEL SYSTEMS FOR BRAIN PATHOLOGY AND CANCER The invention provides non-human transgenic animals as models of neurodegenerative brain pathology, including, but not limited to, Alzheimer's disease (AD), and cancer. The non-human transgenic...
19	7888325	Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.
20	7879791	Regulation of T cell-mediated immunity by tryptophan A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment....
21	US20100324064	NOVEL ANALOGS OF CHOLINE FOR NEUROPROTECTION AND COGNITIVE ENHANCEMENT IN NEURODEGENERATIVE DISORDERS The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease,...
22	US20100316990	Biomarkers for HPV-Induced Cancer Biomarkers that correlate with progression to neoplasia in human papillomavirus (HPV) induced cancer, for example cervical cancer have been identified. These biomarkers can be used to diagnosis or...
23	US20100311804	USE OF INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE IN COMBINATION WITH OTHER THERAPEUTIC MODALITIES The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic...
24	7847069	Antibodies against SUMO4 polypeptides Antibodies selectively directed against SUM04 polypeptides are provided. The antibodies are useful research tools and further in the diagnosis and treatment of Type 1 diabetes.
25	US20100305184	INHIBITORS OF THE ATB(0,+) TRANSPORTER AND USES THEREOF The present invention includes inhibitors of the amino acid transporter ATB0,+ and methods of uses thereof.
26	US20100304388	Biomarker For Successful Aging Without Cognitive Decline Methods and compositions for determining whether a subject will age without developing cognitive decline are provided. An exemplary method includes detecting one or more allelic variants in a gene...
27	US20100297160	High Molecular Weight Amyloid Beta As a Carrier for the Oral Delivery of Vaccine Antigens Compositions and methods are provided for stabilizing polypeptide antigens such as amyloid-beta (Aβ) to produce vaccines for oral delivery. One embodiment provides an immunogenic polypeptide ...
28	US20100291077	Methods and Compositions for Modulating ERBB2 Activity Modulating the interaction between ErbB2 and Erbin is an effective method for treating one or more symptoms of ErbB2-mediated disorders. It has been discovered that Erbin stabilizes ErbB2 in vivo...
29	US20100278907	Immunogenic Compositions Containing Ceramide and Methods of Use Thereof Immunogenic compositions containing ceramide or ceramide analogs for treating or reducing the risk of developing one or more symptoms of a disease or disorder associated with ceramide-induced cell...
30	US20100266588	Breast Cancer Susceptibility Gene GT198 and Uses Thereof It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice...
31	US20100260774	Netrin-1 Compositions and Methods of Use Thereof Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to...
32	7786147	Analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease,...
33	US20100212038	TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain...
34	US20100200771	MICROIRRADIATORS AND METHODS OF MAKING AND USING SAME Improved radiation devices and their associated fabrication and applications are described herein. The microirradiators generally include a non-radioactive conducting electrode, an insulating...
35	7763251	Kits to assess the risk of tumor progression The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase...
36	7732470	Compositions and methods for the treatment of renal and cardiovascular disease Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative...
37	US20100137236	Compositions Comprising a GPR109 Ligand For Treating Disorders of the Digestive Tract and/or Cancer Pharmaceutical compositions containing an effective amount of a ligand for GPR109 to decrease intracellular cAMP levels of a subject in combination with an effective amount of a DNA methyl...
38	US20100136004	COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote...
39	US20100111943	COMPOSITIONS AND METHODS FOR INHIBITING CANCER METASTASIS It has been discovered that antagonists of acetylated heat shock proteins can inhibit or reduce tumor cell invasion or metastasis. Compositions and methods for inhibiting tumor cell invasion or...
40	US20100086618	Methods and Systems for Mineralization of Demineralized Tissue Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the...
41	US20090312778	APPARATUS FOR REMOVING PLAQUE FROM AN ARTERIAL WALL AND METHOD OF USE THEREFOR A surgical extractor including an elongated body having a handle and working tool coupled thereto. The extractor also includes at least one user operated button and at least one blade mechanically...
42	US20090267603	System and method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces A method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces is disclosed. The method includes the steps of scanning a test object having a plurality of anisotropic...
43	7598287	Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic...
44	US20090196859	Oligodendrocyte Precursor Cell Composition and Methods of Use The present invention provides a cell culture enriched for sphingolipid enhances neural stem cells (SENSe), particularly oligodendrocyte precursor cells (ODPCs), that do not form teratomas after...
45	US20090190817	Systems and methods for parametric mapping for correction of noise -based systematic bias of DTI metrics, using a DTI mapping phantom A system and method for minimizing, if not completely eliminating, the systematic bias present in an MR system used for DTI is disclosed. A test object or “phantom” of the present invention is sca...
46	US20090190816	Systems and methods for rescaling image intensities with diffusion MRI to synthesize complex diffusive geometries A method for scaling MR signal intensity after noise has been removed is disclosed. Because the signal in a DTI series varies with the apparent diffusivity in the direction of an applied gradient,...
47	7550617	Compositions and methods for the treatment of renal and cardiovascular disease Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative...
48	US20090123420	Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase The present invention provides improved treatment methods by the administration of the non-physiologic D-isomer of an IDO inhibitor.
49	US20090123388	Prodrugs of Short-Chain Fatty Acids and Treatment Methods Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB0,+ are provided. The...
50	US20090081155	Use of Inhibitors of Indoleamine-2,3-Dioxygenase in Combination with Other Therapeutic Modalities The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic...

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