Patents and Patent Applications from Medical College of Georgia Research Institute


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9447166 Compositions and methods for the intracellular disruption of VEGF and VEGFR-2 by intraceptors  
The present invention provides an intraceptor that interacts with and decreases activity of with VEGF and/or a VEGFR for the treatment of angiogenesis-related conditions. The present invention...
US20150152413 Composition and Method for In Vivo and In Vitro Attenuation of Gene Expression Using Double Stranded RNA  
Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.
9044431 Methods of treating stroke using stem cell-like menstrual blood cells  
A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of...
8591537 Surgical appratus for cutting tissue  
A system of separating a membrane from underlying tissue. The system includes a separation member operable to separate the membrane from the tissue and a cutting element in communication with the...
8524228 Netrin-1 compositions and methods of use thereof  
Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to...
8461114 Methods and compositions for modulating ErbB2 activity  
Modulating the interaction between ErbB2 and Erbin is an effective method for treating one or more symptoms of ErbB2-mediated disorders. It has been discovered that Erbin stabilizes ErbB2 in vivo...
8435947 Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity  
Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a...
8431392 Shortened Alk1 regulatory fragment  
Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or...
US20120329860 Uses of Beta-Nicotinamide Adenine Dinucleotide  
The present invention provides methods for treating inflammation in the lungs of a subject in need of such treatment, comprising the step of administering an effective amount of a composition...
US20120288472 REGULATION OF T CELL-MEDIATED IMMUNITY BY TRYPTOPHAN  
A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment...
8309534 Compositions comprising a GPR109 ligand for treating disorders of the digestive tract and/or cancer  
Pharmaceutical compositions containing an effective amount of a ligand for GPR109 to decrease intracellular cAMP levels of a subject in combination with an effective amount of a DNA methyl...
8287923 Compositions and methods for treating immune disorders  
Green tea polyphenol compositions and methods of their use are provided. Certain aspects provide methods for modulating expression of one or more autoantigens using the disclosed green tea...
8236765 Ganglioside epitopes for treating guillain-barre syndrome  
Disclosed are compositions and methods for treating Guillain-Barré syndrome (GBS) in a subject that involves neutralizing specific pathogenic anti-glycolipid antibodies in the circulation of the...
8216787 Biomarker for successful aging without cognitive decline  
Methods and compositions for determining whether a subject will age without developing cognitive decline are provided. An exemplary method includes detecting one or more allelic variants in a gene...
8211864 Compositions and methods for the intracellular disruption of VEGF and VEGFR-2 by intraceptors  
The present invention provides an intraceptor that interacts with and decreases activity of with VEGF and/or a VEGFR for the treatment of angiogenesis-related conditions. The present invention...
8198265 Regulation of T cell-mediated immunity by tryptophan  
A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment....
US20120142750 INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS  
The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.
US20120141998 ANTIGEN-PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS FOR ENHANCING OR REDUCING IMMUNE TOLERANCE  
The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase...
US20120115785 ENDOTHELIAL NITRIC OXIDE SYNTHASE ANTAGONISTS AND USES THEREOF FOR INHIBITING OXYGEN TOXICITY  
Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a...
8169216 System and method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces  
A method for synthesizing crossing ADC distributions via reassembly of multiple k-spaces is disclosed. The method includes the steps of scanning a test object having a plurality of anisotropic...
8134363 Test object for use with diffusion MRI and system and method of synthesizing complex diffusive geometries using novel gradient directions  
A test object for use with diffusion MRI and a system and methods of synthesizing complex diffusive geometries. The test object, which includes anisotropic structures, can be used to monitor DTI...
8098068 Systems and methods for parametric mapping for correction of noise-based systematic bias of DTI metrics, using a DTI mapping phantom  
A system and method for minimizing, if not completely eliminating, the systematic bias present in an MR system used for DTI is disclosed. A test object or “phantom” of the present invention is...
US20120009271 METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION  
Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present...
US20110305713 METHODS AND COMPOSITIONS TO ENHANCE VACCINE EFFICACY BY REPROGRAMMING REGULATORY T CELLS  
The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining LNs, where it can potently activate Foxp3 regulatory T...
US20110300241 ORAL CARE COMPOSITIONS FOR TREATING XEROSTOMIA  
Disclosed herein are oral care compositions for promoting salivary flow. Thus, also disclosed are methods of treating and preventing xerostomia. The oral care compositions can contain all-natural...
8058612 Microirradiators and methods of making and using same  
Improved radiation devices and their associated fabrication and applications are described herein. The microirradiators generally include a non-radioactive conducting electrode, an insulating...
US20110268710 METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS  
A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of...
US20110245339 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS  
Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB0,+ are provided. The...
7994784 Systems and methods for rescaling image intensities with diffusion MRI to synthesize complex diffusive geometries  
A method for scaling MR signal intensity after noise has been removed is disclosed. Because the signal in a DTI series varies with the apparent diffusivity in the direction of an applied gradient,...
7985586 Oligodendrocyte precursor cell composition and methods of use  
The present invention provides a cell culture enriched for sphingolipid enhances neural stem cells (SENSe), particularly oligodendrocyte precursor cells (ODPCs), that do not form teratomas after...
US20110136894 Shortened Alk1 Regulatory Fragment  
Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or...
US20110135672 HLA-G COMPOSITIONS AND METHODS OF USE THEREOF  
It has been discovered that HLA-G dimers are potent ligands of ILT2 and ILT4 on immune cells and enhance signal transduction through ILT2 and ILT4. Enhanced signal transduction through ILT-2,...
US20110135572 COMPOSITIONS AND METHODS FOR DIAGNOSING LATE-ONSET ALZHEIMER'S DISEASE  
Genetic markers for late-onset Alzheimer's disease (AD) within the TRPC4AP gene locus are provided. The genetic markers include single nucleotide polymorphisms (SNPs) and haplotypes. Methods and...
US20110131669 GANGLIOSIDE EPITOPES FOR TREATING GUILLAIN-BARRE SYNDROME  
Disclosed are compositions and methods for treating Guillain-Barré syndrome (GBS) in a subject that involves neutralizing specific pathogenic anti-glycolipid antibodies in the circulation of the...
US20110124720 COMPOSITIONS AND METHODS FOR TREATING IMMUNE DISORDERS  
Green tea polyphenol compositions and methods of their use are provided. Certain aspects provide methods for modulating expression of one or more autoantigens using the disclosed green tea...
US20110123590 Selective Expansion of Regulatory T Cells  
Methods for expanding regulatory T cells in vitro are provided. It has been discovered that regulatory T cells can be expanded in vitro by culturing a mixed population of lymphocytes on planar...
7938643 Use of integrating sphere technology to provide uniform, high-intensity light, and wavelength mixing from light emitting diodes  
An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be...
US20110047631 HEAT SHOCK PROTEIN DEFICIENCIES AS MODEL SYSTEMS FOR BRAIN PATHOLOGY AND CANCER  
The invention provides non-human transgenic animals as models of neurodegenerative brain pathology, including, but not limited to, Alzheimer's disease (AD), and cancer. The non-human transgenic...
7888325 Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA  
Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.
7879791 Regulation of T cell-mediated immunity by tryptophan  
A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment....
US20100324064 NOVEL ANALOGS OF CHOLINE FOR NEUROPROTECTION AND COGNITIVE ENHANCEMENT IN NEURODEGENERATIVE DISORDERS  
The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease,...
US20100316990 Biomarkers for HPV-Induced Cancer  
Biomarkers that correlate with progression to neoplasia in human papillomavirus (HPV) induced cancer, for example cervical cancer have been identified. These biomarkers can be used to diagnosis or...
US20100311804 USE OF INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE IN COMBINATION WITH OTHER THERAPEUTIC MODALITIES  
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic...
7847069 Antibodies against SUMO4 polypeptides  
Antibodies selectively directed against SUM04 polypeptides are provided. The antibodies are useful research tools and further in the diagnosis and treatment of Type 1 diabetes.
US20100305184 INHIBITORS OF THE ATB(0,+) TRANSPORTER AND USES THEREOF  
The present invention includes inhibitors of the amino acid transporter ATB0,+ and methods of uses thereof.
US20100304388 Biomarker For Successful Aging Without Cognitive Decline  
Methods and compositions for determining whether a subject will age without developing cognitive decline are provided. An exemplary method includes detecting one or more allelic variants in a gene...
US20100297160 High Molecular Weight Amyloid Beta As a Carrier for the Oral Delivery of Vaccine Antigens  
Compositions and methods are provided for stabilizing polypeptide antigens such as amyloid-beta (Aβ) to produce vaccines for oral delivery. One embodiment provides an immunogenic polypeptide...
US20100291077 Methods and Compositions for Modulating ERBB2 Activity  
Modulating the interaction between ErbB2 and Erbin is an effective method for treating one or more symptoms of ErbB2-mediated disorders. It has been discovered that Erbin stabilizes ErbB2 in vivo...
US20100287627 Transgenic Zebrafish Models for Neurodegenerative Diseases  
The present invention relates to zebrafish models for neurodegenerative disorders that allow screening of compounds for their ability to protect and/or regenerate neurons in vivo in a whole...
US20100278907 Immunogenic Compositions Containing Ceramide and Methods of Use Thereof  
Immunogenic compositions containing ceramide or ceramide analogs for treating or reducing the risk of developing one or more symptoms of a disease or disorder associated with ceramide-induced cell...
Matches 1 - 50 out of 160 1 2 3 4 >