Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20180205020 EMISSIVE COMPOUNDS AND RELATED DEVICES  
In one aspect, compositions comprising emissive compounds including polycyclic aromatic groups are provided. In some embodiments, the emissive compounds may include various moieties having...
US20180204379 System and Method for Providing Reconstruction of Human Surfaces from Orientation Data  
A system and method for reconstructing a positional contour of a variably contoured surface includes a plurality of positional sensors and a plurality of orientation sensor disposed upon the...
US20180204158 Data-Driven System for Optimal Vehicle Fleet Dimensioning and Real-Time Dispatching Based on Shareability Networks  
Real-time, point-to-point, on-demand ride dispatching system. The system provides for optimal operation including a fleet dimensioning module for determining an optimal number of vehicles in a...
US20180202935 Multifocal imaging systems and method  
In the systems and methods of the present invention a multifocal multiphoton imaging system has a signal to noise ratio (SNR) that is reduced by over an order of magnitude at imaging depth equal...
US20180202375 OPTIMIZED FUEL MANAGEMENT SYSTEM FOR DIRECT INJECTION ETHANOL ENHANCEMENT OF GASOLINE ENGINES  
Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. It is preferred that the direct...
US20180201889 DELIVERY OF MATERIALS TO ANUCLEATE CELLS  
The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system,...
US20180201658 SELECTIVE MCL-1 BINDING PEPTIDES  
Provided herein are stabilized peptides that bind Mcl-1. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include...
10028369 Particle acceleration in a variable-energy synchrocyclotron by a single-tuned variable-frequency drive  
Ions are released over time from an ion source into a beam area proximate a central axis. A radiofrequency (RF) system with a variable frequency and variable voltage accelerates the ions in...
10027399 Method for coding-based, delay-efficient data transmission  
A method, apparatus and computer program product for -based, delay-efficient data transmission for broadcasting a single file is presented. A file (f) comprised of K packets to be broadcast to a...
10024978 Travel survey systems and methods  
Systems and methods for collecting travel data include a mobile application capable of being executed on a mobile computing device and configured to monitor and log travel data related to travel...
10024860 Cancer-related extracellular matrix signatures and related methods and products  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
10024723 Detection of electromagnetic radiation using nonlinear materials  
An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate....
10023536 Suprametallogels and uses thereof  
The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and...
10022709 Process for the production of non-sintered transition metal carbide and nitride nanoparticles  
Transition metal carbide, nitride, phosphide, sulfide, or boride nanoparticles can be made by transforming metal oxide materials coated in a ceramic material in a controlled environment. The...
10022542 Low power cochlear implants  
In one aspect, the disclosure features systems for providing auditory signals to a subject. The systems include a sensor front-end circuit configured to be connected to an acoustic sensor and to...
US20180198256 Method for High-Concentration Doping of Germanium with Phosphorous  
In a method for electrically doping a semiconducting material, a layer of germanium is formed having a germanium layer thickness, while in situ incorporating phosphorus dopant atoms at a...
US20180197999 HIGH-LINEARITY TRANSISTORS  
A transistor includes a first gate-controlled region having a first threshold voltage and a second gate-controlled region in parallel with the first gate-controlled region. The second...
US20180197736 SYSTEMS AND METHODS FOR GRAPHENE BASED LAYER TRANSFER  
A graphene-based layer transfer (GBLT) technique is disclosed. In this approach, a device layer including a III-V semiconductor, Si, Ge, III-N semiconductor, SiC, SiGe, or II-VI semiconductor is...
US20180197686 LUBRICANT-IMPREGNATED SURFACES FOR ELECTROCHEMICAL APPLICATIONS, AND DEVICES AND SYSTEMS USING THE SAME  
In certain embodiments, the invention relates to an electrochemical device having a liquid lubricant impregnated surface. At least a portion of the interior surface of the electrochemical device...
US20180196058 MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS  
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography...
US20180196025 CHEMICAL SENSOR FOR HEAVY METAL DETECTION  
A chemical sensor for heavy metal detection is provided. The chemical sensor includes an inlet, a chamber in fluid communication with the inlet, and an outlet in fluid communication with the...
US20180195213 Active Woven Materials  
Active fabrics typically include a plurality of fibers. At least one of the fibers exhibits a change in length or width upon exposure to an external stimulus, such as heat, moisture, or light. The...
US20180194106 Active Lattices  
An active lattice capable of self-transforming responsive to a stimulus, such as heat or moisture, includes a plurality of links interconnected to each other at a plurality of nodes. At least a...
US20180194066 SYSTEMS AND METHODS OF MACHINE VISION ASSISTED ADDITIVE FABRICATION  
The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration...
US20180193518 Controllably Degradable Compositions and Methods  
Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an...
US20180192974 Integrated Optical Blocking Filter for Compact X-Ray Imaging Detector  
An x-ray imaging device can include an x-ray detector and an optical-blocking filter. The x-ray detector has an entrance-window surface for receiving x-rays, at least one side surface, and a back...
10017724 Engineering of a novel breast tumor microenvironment on a microfluidic chip  
A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may...
10017520 Myc modulators and uses thereof  
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating...
10017388 Dihydrogen tetrametaphosphate, its derivatives, and preparation thereof  
Dihydrogen metaphosphate can be synthesized via protonation, and can react with a dehydrating agent to afford tetrametaphosphate anhydride. A monohydrogen tetra-metaphosphate organic ester can be...
US20180190973 SYSTEMS AND METHODS OF PREPARING LITHIUM SULFUR ELECTRODE USING SACRIFICIAL TEMPLATE  
Embodiments described herein relate generally to lithium sulfur batteries and methods of producing the same. As described herein, preventing coarsening of sulfur during the well-known...
US20180188151 Method to Distinguish and Analyze White Blood Cells in the Presence of Red Blood Cells  
Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing...
US20180187186 COMPOSITIONS COMPRISING NUCLEIC ACIDS AND METHODS OF USING THE SAME  
The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or...
US20180187183 DNA MICROSCOPY  
The present invention relates to DNA microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with...
US20180187169 THIOLASE VARIANTS AND METHODS OF USE THEREOF  
Described herein are thiolase variants, cells expressing the thiolase variants, and methods of their use for the biosynthesis of desired products.
US20180187072 LIGANDS FOR SEMICONDUCTOR NANOCRYSALS  
In this invention, polyimidazole ligands (PILs) incorporating pendant imidazole moieties for nanocrystal binding and either sulfonatebetaine, carboxybetaine, or phosphocholinebetaine moieties for...
US20180185791 MITIGATING LEAKS IN MEMBRANES  
Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a...
US20180185513 NANO-FIBULAR NANOPARTICLE POLYMER-DRUG CONJUGATE FOR SUSTAINED DERMAL DELIVERY OF RETINOIDS  
Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically...
US20180185473 LIPID VESICLE COMPOSITIONS AND METHODS OF USE  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
US20180185286 POROUS MATERIALS CONTAINING COMPOUNDS INCLUDING PHARMACEUTICALLY ACTIVE SPECIES  
Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or...
10014438 Light emitting device including semiconductor nanocrystals  
A light emitting device includes a semiconductor nanocrystal and a charge transporting layer that includes an inorganic material. The charge transporting layer can be a hole or electron...
10013391 Architecture emulation in a parallel processing environment  
An integrated circuit includes a plurality of processor core. Processing instructions in the integrated circuit includes: managing a plurality of sets of processor cores, each set including one or...
10012657 Optical nanosensors comprising photoluminescent nanostructures  
Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a...
10012569 Microfluidic bubble logic devices  
Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices,...
10011817 Cell rolling separation  
The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and...
10011336 Underwater vehicle design and control methods  
Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.
10011335 Underwater vehicle design and control methods  
Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.
10010709 Composition for on-demand ultrasound-triggered drug delivery  
Injectable or implantable drug delivery systems providing on-demand ultrasound-triggered drug release and methods for controlling the release of drug in a patient are provided herein. The...
US20180184024 METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE (THDR) TIME-DELAY-AND-INTEGRATE (TDI) IMAGING  
In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic...
US20180181540 SYSTEMS AND METHODS FOR DISTRIBUTED SOLUTION OF OPTIMIZATION PROBLEMS  
A framework is presented for designing a class of distributed, asynchronous optimization algorithms realized as signal processing architectures utilizing various conservation principles. The...
US20180180811 WAVEGUIDE FORMATION USING CMOS FABRICATION TECHNIQUES  
Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon...