Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20170356477 ARTICLES AND METHODS FOR LEVITATING LIQUIDS ON SURFACES, AND DEVICES INCORPORATING THE SAME  
Methods described herein provide a way to reduce or eliminate drag and adhesion of a substance flowing over a surface by creating a vapor cushion via evaporation of a phase-changing material of or...
US20170355945 Microfluidic Device for Three Dimensional and Compartmentalized Coculture of Neuronal and Muscle Cells, with Functional Force Readout  
The present subject matter provides a microfluidic device that enables the precise and repeatable three dimensional and compartmentalized coculture of muscle cells and neuronal cells. Related...
US20170355799 BIOCOMPATIBLE COATINGS AND HYDROGELS FOR REDUCING FOREIGN BODY RESPONSE AND FIBROSIS  
Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a...
US20170354609 PHARMACEUTICAL TABLET COATING PROCESS BY INJECTION MOLDING PROCESS TECHNOLOGY  
The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g.,...
US20170354363 PHONOLOGICALLY-BASED BIOMARKERS FOR MAJOR DEPRESSIVE DISORDER  
A system and a method for assessing a condition in a subject. Phones from speech of the subject are recognized, one or more prosodic or speech-excitation-source features of the phones are...
9842721 Systems and methods for particle pulse modulation  
Methods and apparatus for modulating a particle pulse include a succession of Hermite-Gaussian optical modes that effectively construct a three-dimensional optical trap in the particle pulse's...
9842404 Methods and apparatus for refractive flow measurement with three dimensions and uncertainty  
An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video...
9841606 Optical filters with engineered birefringence  
An embodiment according to the invention provides an optical filter that combines narrow spectral bandwidth and high rejection of out-of-band radiation with a wide acceptance angle. These filters...
9841544 Device and method for luminescence enhancement by resonant energy transfer from an absorptive thin film  
Disclosed are a device and a method for the design and fabrication of the device for enhancing the brightness of luminescent molecules, nanostructures, and thin films. The device includes a...
9841186 Tunable nucleate boiling using electric fields and ionic surfactants  
A tunable boiling system includes a fluid having a solvent and an ionic surfactant in the solvent, a counter electrode disposed within the fluid, and a working electrode having a surface in...
9840713 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
9840479 Polyamine-fatty acid derived lipidoids and uses thereof  
The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of Formula (I) or (II)) and methods of preparing the lipidoids. A described lipidoid includes R—C(═O)—O—...
US20170353293 METHOD FOR TRANSIENT CHANGE DETECTION WITH ADAPTIVE SAMPLING, AND DETECTOR IMPLEMENTING THE METHOD  
A method of detecting transient changes in the distribution of a discrete time series includes: operating in a sparse mode wherein, at sniff periods successively repeated at a first rate, at most...
US20170352771 Systems, Methods, and Apparatus for Concentrating Photovoltaic Cells  
A photovoltaic (PV) apparatus includes a substrate having a first substrate surface and a second substrate surface. A cavity fabricated in the substrate extends from the first substrate surface...
US20170352538 Systems and Methods for Fabricating Single-Crystalline Diamond Membranes  
A buffer layer is employed to fabricate diamond membranes and allow reuse of diamond substrates. In this approach, diamond membranes are fabricated on the buffer layer, which in turn is disposed...
US20170351293 Apparatus and Methods for Optical Neural Network  
An optical neural network is constructed based on photonic integrated circuits to perform neuromorphic computing. In the optical neural network, matrix multiplication is implemented using one or...
US20170349950 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF  
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell...
US20170349914 DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF CRISPR SYSTEMS AND COMPOSITIONS FOR GENOME EDITING AS TO HEMATOPOIETIC STEM CELLS (HSCs)  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20170349894 ESCORTED AND FUNCTIONALIZED GUIDES FOR CRISPR-CAS SYSTEMS  
The present invention generally relates to CRISPR systems or complexes, such as those with an escorted guide RNA.
US20170349884 Production of Differentiated Enteroendocrine Cells and Insulin Producing Cells  
A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a...
US20170349650 IMMUNOGLOBULINS WITH REDUCED AGGREGATION  
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such...
US20170348431 DRUG DELIVERY POLYMERS AND USES THEREOF  
Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are...
US20170348176 High Performance Free Rolling Cable Transmission  
A mechanical transmission, tethered actuation system, an autonomous ankle exoskeleton design and method of their use employing a cable, pulleys and associated pulley housings to change angular...
9839073 Multifunctional CNT-engineered structures  
Various applications for structured CNT-engineered materials are disclosed herein. In one application, systems are disclosed, wherein a structured CNT-engineered material forms at least part of an...
9837953 Metallic dielectric photonic crystals and methods of fabrication  
A metallic-dielectric photonic crystal is formed with a periodic structure defining a plurality of resonant cavities to selectively absorb incident radiation. A metal layer is deposited on the...
9837237 Pyrolyzed porous carbon materials and ion emitters  
Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described.
9835885 Systems, methods, and apparatus for sensitive thermal imaging  
The high-pixel-count uncooled thermal imaging arrays disclosed herein have liquid crystal (LC) microcavity transducers separate from the read-out integrated circuit (ROIC). The transducer converts...
9835363 Evaporative heat transfer system  
Evaporative heat transfer system. The system includes a substrate and a plurality of substantially parallel, spaced-apart ridges extending from the substrate forming vertical liquid manifolds...
9834747 Methods and apparatus for transplantation of nucleic acid molecules  
In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some...
US20170346283 Systems and Methods for Modular DC Microgrids with Control of Loads  
The systems and methods described herein are directed towards a microgrid having modular power management units to control and regulate power to maintain a stable energy environment and provide...
US20170344699 WATER-SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF  
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
US20170343553 CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
US20170342077 DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS  
Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are...
US20170341316 COMPOSITE ARTICLES COMPRISING NON-LINEAR ELONGATED NANOSTRUCTURES AND ASSOCIATED METHODS  
The present disclosure relates to composite articles comprising non-linear elongated nanostructures and associated systems and methods. In certain embodiments, collections of carbon nanotubes or...
US20170341034 GRAPHENE OXIDE MEMBRANES AND RELATED METHODS  
Membranes comprising graphene oxide sheets and associated filter media and methods are provided. In some embodiments, a membrane may comprise graphene oxide sheets that have undergone one or more...
US20170341010 COMPOSITIONS COMPRISING METAL ORGANIC FRAMEWORKS FOR THE UPTAKE OF COMPOUNDS AND RELATED METHODS  
Compositions and methods for adsorption of a species (e.g., ammonia, water, a halogen) comprising metal organic frameworks (MOFs) are generally provided. In some embodiments, a MOF comprises a...
9831722 Wireless non-radiative energy transfer  
Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a...
9831682 Efficient near-field wireless energy transfer using adiabatic system variations  
Disclosed is a method for transferring energy wirelessly including transferring energy wirelessly from a first resonator structure to an intermediate resonator structure, wherein the coupling rate...
9829728 Method for forming magneto-optical films for integrated photonic devices  
Methods for forming magneto-optical films for integrated photonic devices and integrated photonic devices incorporating same are described. An optical isolator or any nonreciprocal photonic...
9829379 Two-dimensional spectroscopy system and two-dimensional spectroscopic analysis method  
A two-dimensional (2D) spectroscopy system and a 2D spectroscopic analysis method are disclosed. The 2D spectroscopy system includes: a light transmission delayer configured for forming a...
9828251 Silica aerogels and their preparation  
Silica aerogels with improved properties are disclosed together with methods for synthesizing such aerogels. The improved properties include lower thermal conductivity (better insulating...
9827007 Tissue collection needle  
A tissue collection needle with a hollow interior provides two opposing tips with beveled edges on facets that drive tissue toward the hollow interior where the tissue can be gathered and severed...
US20170339431 System and Method for Providing Real-Time Super-Resolution for Compressed Videos  
A real-time system and method for displaying video on a display are disclosed. Received compressed video data is decoded to produce an uncompressed first video frame, a first frame syntax element,...
US20170338943 DNA ENCRYPTION TECHNOLOGIES  
In some aspects, the instant disclosure relates to the multiplexed encryption of information on nucleic acid molecules. In some aspects, the instant disclosure relates to a method of secure...
US20170338122 Methods and Apparatus for Variable Selectivity Atomic Layer Etching  
A method of fabricating a microelectronic device, such as a high electron mobility transistors (HEMT), is disclosed. In some examples, the method comprises placing a masked semiconductor sample...
US20170336482 Systems, Apparatus, and Methods of Nonlinear Terahertz (THz) Magnetic Resonance Measurement  
A nonlinear terahertz (THz) spectroscopy technique uses a sample illuminated by two THz pulses separately. The illumination generates two signals BA and BB, corresponding to the first and second...
US20170336102 Enhanced Thermal Stability on Multi-Metal Filled Cermet Based Spectrally Selective Solar Absorbers  
A spectrally selective solar absorber is described and comprises a substrate, double cermet layers comprising multi-metal nanoparticles embedded in a dielectrics matrix, and double antireflection...
US20170335411 CORRECTING CROSSTALK IN BIOLOGICAL SYSTEMS  
Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.
US20170335406 METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS  
Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
US20170335334 DNA CLOAKING TECHNOLOGIES  
The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid...