Patents and Patent Applications from Massachusetts Institute of Technology MIT


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7658868 Molecular actuators, and methods of use thereof  
The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result...
US20100029003 System and methods for identifying miRNA targets and for altering miRNA and target expression  
The present invention generally relates to microRNAs such as vertebrate microRNA (miRNA), for example, mammalian miRNA. Various aspects of the invention are directed to the detection, production,...
US20100027739 Phase-Contrast X-Ray Imaging  
Phase-contrast imaging is performed by directing radiation from a plurality of pinhole sources through a a phase object to be imaged, wherein the phase object includes a first composition that...
US20100025787 System and method for providing a high frequency response silicon photodetector  
A Silicon photodetector contains an insulating substrate having a top surface and a bottom surface. A Silicon layer is located on the top surface of the insulating substrate, where the Silicon...
US20100025630 COMPOSITIONS INCLUDING POLYMERS ALIGNED VIA INTERCHAIN INTERACTIONS  
The present invention provides compositions, devices and methods related to the alignment of materials including polymers. In some cases, the present invention comprises the assembly of molecules...
7656258 Magnet structure for particle acceleration  
A magnet structure for particle acceleration includes at least two coils that include a continuous path of superconducting material [e.g., niobium tin (Nb 3 Sn) having an A15-type crystal...
7655465 Methods for ex vivo propagation of somatic hair follicle stem cells  
The present invention is directed to methods for readily propagating somatic hair follicle stem cells or melanocyte stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis,...
7655445 Methods for synthesis of sulfated saccharides  
The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the...
US20100022680 Microfluidic Synthesis of Organic Nanoparticles  
The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful...
US20100022011 DETERMINATION OF EXPLOSIVES INCLUDING RDX  
The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material...
US20100021843 Inorganic Resist Sensitizer  
Methods and compositions for enhancing the sensitivity of an inorganic resist composition are disclosed. In one aspect, compositions for use with a matrix material (e.g., a lithographically...
US20100021708 Large-Area Single- and Few-Layer Graphene on Arbitrary Substrates  
A film of single-layer to few-layer graphene is formed by depositing a graphene film via chemical vapor deposition on a surface of a growth substrate. The surface on which the graphene is deposited...
US20100019764 UNIFORM MAGNETIC FIELD SPHERICAL COIL FOR MRI  
The present invention relates to a spherical design for a magnetic resonance imaging (MRI) coil to provide a compact and light-weight highly uniform magnetic field for a variety of medical imaging...
7651979 Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same  
The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity. In...
7651926 Rapid patterning of nanostructures  
A process for forming nanostructures comprises generating charged nanoparticles with an electrospray system in a vacuum chamber and introduction of the charged nanoparticles to a region proximate...
7651821 Method and system of lithography using masks having gray-tone features  
A method forms patterns on a substrate by exposing the substrate a first time and exposing the substrate a second time using a mask containing gray-tone features. The gray-tone features locally...
7651760 Superhydrophobic fibers produced by electrospinning and chemical vapor deposition  
Disclosed is a versatile method to produce superhydrophobic surfaces by combining electrospinning and initiated chemical vapor deposition (iCVD). A wide variety of surfaces, including electrospun...
7651600 Electrokinetic concentration device and methods of use thereof  
The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods, inter-alia, make use of a device...
7651475 Microneedle transport device  
A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to...
US20100016827 NEEDLE-FREE INJECTOR DEVICE WITH AUTOLOADING CAPABILITY  
A needle-free transdermal transport device includes a chamber ( 900 ) for holding the substance to be injected, a nozzle ( 910 ) in fluid communication with the chamber, and a drug reservoir ( 950...
US20100016736 Estimating Aortic Blood Pressure from Non-Invasive Extremity Blood Pressure  
Methods and a computer program product for using a circulatory measurement on an extremity of a particular subject to derive an aortic blood pressure for that subject. A model is constructed that...
US20100015130 DISC-1 PATHWAY ACTIVATORS IN THE CONTROL OF NEUROGENESIS  
The invention relates to methods of treating neurological disorders in a subject, by activating a DISC1 pathway. Methods of promoting neurogenesis in adult neural progenitor cells, enhancing nerve...
US20100015068 Methods and Compositions For Altering Biological Surfaces  
Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that...
US20100014799 Optical structures including nanocrystals  
An optical structure can include a nanocrystal on a surface of an optical waveguide in a manner to couple the nanocrystal to the optical field of light propagating through the optical waveguide to...
7649196 Light emitting device  
A light emitting device includes an optical cavity in resonance with an optical transition of a material disposed in the cavity. The device can form an exciton-polariton state.
7648739 Switchable surfaces  
A substrate having a surface with reversibly switchable properties. The surface comprises a nanolayer of a material that switches from a first conformation state to a second conformation state when...
US20100009914 METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT  
In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble...
US20100009289 RESIST SENSITIZER  
Methods and compositions for enhancing the sensitivity of a resist composition are disclosed. In one aspect, compositions for use with a matrix material (e.g., a lithographically sensitive...
US20100008901 METHODS FOR THE TREATMENT AND PREVENTION OF CANCER  
The present inventions features methods for treating or preventing cancer (e.g., cancer of the central nervous system) by administering a compound that inhibits PAK kinase activity and/or merlin...
US20100007248 ELECTROCHEMICAL METHODS, DEVICES, AND STRUCTURES  
The present invention provides devices and structures and methods of use thereof in electrochemical actuation. This invention provides electrochemical actuators, which are based, inter-alia, on an...
7647092 Systems and methods for spectroscopy of biological tissue  
The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In...
7645610 Hepatocyte precursor cell lines  
The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods...
7645263 Impedance sensor  
A transdermal transport device includes a reservoir for holding a formulation of an active principle, a needle with a bore through which the formulation is transported between the reservoir and a...
7644489 Thin membrane alignment method using patterned nanomagnets  
A passive nanomagnet alignment method is described to self-align a membrane to another surface. The membrane and the surface each have a plurality of nanomagnets patterned on it, wherein the...
US20100004624 MEASURING PROPERTIES OF AN ANATOMICAL BODY  
A medical device includes a sensor that is configured to measure a property of an outer layer of an anatomical body surface. The sensor includes a source probe configured stimulate a local surface...
US20100004195 Decoy Influenza Therapies  
The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys....
US20100003700 Optoelectronic sensor  
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where...
US20100003297 Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues  
A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment,...
US20100002739 LENS COUPLED QUANTUM CASCADE LASER  
Terahertz quantum cascade (QC) devices are disclosed that can operate, e.g., in a range of about 1 THz to about 10 THz. In some embodiments, QC lasers are disclosed in which an optical element...
US20100001256 White light emitting devices  
A white light emitting semiconductor nanocrystal includes a plurality of semiconductor nanocrystals.
7643015 Systems and methods for tracking impacts  
Surface impacts are located and characterized based on an acoustic signal produced by the impact despite the presence of signal dispersion. Acoustic signals from the surface may be compared to...
7642989 System for and method of motion and force synchronization with time delay reduction in multi-user shared virtual environments  
Systems, methods and computer-executable code stored on computer readable media for synchronizing the evolving state of a dynamic object in a shared virtual environment among a plurality of...
7642096 Liquid expansion thermometer and microcalorimeter  
A calorimeter is provided for measuring a quantity of heat. The calorimeter has a liquid constrained so as to allow expansion of the liquid solely in one dimension along a single axis such that...
7641882 Fullerenic structures and such structures tethered to carbon materials  
The fullerenic structures include fullerenes having molecular weights less than that of C 60 with the exception of C 36 and fullerenes having molecular weights greater than C 60 . Examples...
7641614 Wearable blood pressure sensor and method of calibration  
Methods and apparatus for measuring arterial blood pressure at an extremity of a subject. Arterial blood pressure is derived from a circulatory measurement performed on an extremity of a subject...
7640915 Fuel management system for variable ethanol octane enhancement of gasoline engines  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
US20090326269 Templated Monolayer Polymerization and Replication  
A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers....
US20090326177 Mesostructured Zeolitic Materials and Methods of Making and Using the Same  
One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for...
US20090322636 NOTCH ANTENNA HAVING A LOW PROFILE STRIPLINE FEED  
Described are a notch antenna and an array antenna based on a low profile stripline feed. The notch antenna includes a planar dielectric substrate having upper and lower surfaces. Each surface has...
7638751 Multi-element optical detectors with sub-wavelength gaps  
A multi-element optical detector includes a plurality of optical detector elements capable of producing an output signal having information about the state of an incident electromagnetic radiation...