Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20160328635 Substrate Pre-Scanning for High Throughput Microscopy  
Non-uniformities in substrate thickness and surface topography contribute significantly to the need for auto-focusing on a sample deposited thereon. These auto-focusing needs can be reduced or...
US20160327737 METHOD OF FORMING AN INTEGRATED CIRCUIT AND RELATED INTEGRATED CIRCUIT  
A method (100) of forming an integrated circuit is disclosed. The method comprises: (i) forming at least a pair of optoelectronic devices from at least a first wafer material arranged on a...
US20160327471 T-PEEL TEST FIXTURE  
T-peel test fixture for a vertical test machine. The test fixture includes an upper grip for holding an arm of a peel specimen that has a hangover tail and a lower grip for holding the other arm...
US20160326546 GENERATION OF LAYERED TRANSCRIPTIONAL CIRCUITRY USING CRISPR SYSTEMS  
Provided herein, in some embodiments, are modular transcriptional architectures and methods for regulated expression of guide RNAs in cells, such as human cells, which are based on Clustered...
US20160326535 METABOLIC FLUX BIOSENSOR  
Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the production of metabolites and/or end products...
US20160326431 ONE-POT METHOD FOR PREPARING CORE-SHELL NANOCRYSTALS  
A method for preparing a core-shell nanocrystal can include mixing an M-containing precursor solution, an X-containing precursor solution, and an acid or alcohol in an inert atmosphere at a first...
US20160326295 BROAD WAVELENGTH RANGE CHEMICALLY TUNABLE PHOTONIC MATERIALS  
The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths...
US20160325505 Micro-Pillar Methods and Apparatus  
A computer produces a digital model that efficiently describes a dense array of many micro-pillars. The digital model achieves this efficiency by describing an entire micro-pillar with only a few...
US20160325429 MODULAR ANGULAR-MOMENTUM DRIVEN MAGNETICALLY CONNECTED ROBOTS  
A modular robotic system that includes a plurality of self-configuring robots. Each self-configuring robot includes a frame structure having a plurality of cylindrical bonding magnets positioned...
US20160324793 MODIFIED ALGINATES FOR CELL ENCAPSULATION AND CELL THERAPY  
Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The...
US20160324206 Fused Deposition Model Cold Slurry Printer  
Fused deposition model printer system. The system prints cold slurry substances and includes a source of a cold slurry substance with a print platform supported for at least three axes of motion...
9491859 Grid arrays with enhanced fatigue life  
Reliability is improved for the mechanical electrical connection formed between a grid array device, such as a pin grid array device (PGA) or a column grid array device (CGA), and a substrate such...
9491389 Focal plane array processing method and apparatus  
A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer...
9490330 Controlling GaAsP/SiGe interfaces  
Initiation conditions and strain techniques are described that enable forming high quality GaAsP semiconductor material on an SiGe semiconductor material with low threading defect density....
9488974 Method and apparatus for pulse-modulated feedback control  
A control system and method for controlling a plant based on feedback is described. In some embodiments, the control system uses pulse-modulated (PM) control to overcome friction stickiness.
9488613 Systems, devices and methods for multiplexed diagnostics  
Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary...
9488386 Concentrated solar power system receiver  
Systems and methods for concentrating and storing solar energy are provided. A solar energy receiver for use with the systems and methods may include a container for holding a solar absorption...
9487808 Rapid assembly of multiple arbitrary length DNA fragments  
Aspects herein relate to composition, and related methods, for isolating and assembling DNA molecules without intermediate cloning steps.
9486589 Automated method for simultaneous bubble detection and expulsion  
A method and apparatus for detecting and removing air from a syringe containing a volume of liquid and a volume of gas is described. The method includes moving a piston in the syringe to expel gas...
US20160321519 ASSISTED SURVEILLANCE OF VEHICLES-OF-INTEREST  
A computer-implemented image processing method includes accessing image data representing a plurality of images of a plurality of vehicles and reading a data model representing a predefined...
US20160320837 Methods and Apparatus for Retinal Retroreflection Imaging  
A video camera captures images of retroreflection from the retina of an eye. These images are captured while the eye rotates. Thus, different images are captured in different rotational positions...
US20160319464 METHODS AND SYSTEMS FOR MANUFACTURING A TABLET  
Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example,...
US20160318048 ELECTRICALLY-DRIVEN FLUID FLOW AND RELATED SYSTEMS AND METHODS, INCLUDING ELECTROSPINNING AND ELECTROSPRAYING SYSTEMS AND METHODS  
Systems and methods in which the flow of fluid is electrically driven, including electrospinning and electrospraying systems and methods, are generally described.
US20160317796 TRIGGERABLE SHAPE MEMORY INDUCTION DEVICES  
In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions...
US20160317677 DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR HBV AND VIRAL DISEASES AND DISORDERS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20160317612 ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA NEUTRALIZATION  
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus...
US20160317079 System And Method For Measuring Skin Movement And Strain And Related Techniques  
Described herein are systems and techniques for a motion capture system and a three-dimensional (3D) tracking system used to record body position and/or movements/motions and using the data to...
9484489 Engineered band gaps  
An optoelectronic device as well as its methods of use and manufacture are disclosed. In one embodiment, an optoelectronic device includes first and second semiconducting atomically thin layers...
9483021 Methods and apparatus for holographic animation  
In an illustrative implementation of this invention, an animated holographic display is created as follows: Multiple HPO holograms in the shape of horizontal strips are recorded on an H2 medium....
9482622 Methods and apparatus for surface classification  
In illustrative implementations of this invention, light sources illuminate a surface with multi-spectral, multi-directional illumination that varies in direction, wavelength, coherence and...
9481713 Self-assembling peptides incorporating modifications and methods of use thereof  
The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for...
9481582 Nanocrystal synthesis  
A method of preparing monodisperse MX semiconductor nanocrystals can include contacting an M-containing precursor with an X donor to form a mixture, where the molar ratio between the M containing...
9480404 Method for imaging biomaterial erosion in vivo  
A method for imaging the erosion of a biomaterial is disclosed. More specifically, the present invention provides a method for imaging a labeled biomaterial so that the erosion of the biomaterial...
US20160313425 MICRO MAGNETIC RESONANCE RELAXOMETRY  
A low-cost and bench-top magnetic resonance relaxometer can be used for ex-vivo biochemical stress tests on plasma/erythrocytes, enabling deep-phenotyping of an individual's oxidative status,...
US20160312273 HiC: Method of Identifying Interactions Between Genomic Loci  
The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or...
US20160311727 ALKALI METAL ION SOURCE WITH MODERATE RATE OF ION RELEASE AND METHODS OF FORMING  
An alkali metal ion source with a moderate rate of release of the ion (e.g. potassium) is formed by a method that includes: 1) combining an particulate ore that contains at least one of an alkali...
9479771 Using multiple transform/subband representations for video encoding  
A method of encoding a sequence of video frames, comprising receiving a sequence of video frames, encoding at least a first portion of the sequence of frames using the first type of...
9478429 Removable templates for directed self assembly  
A sacrificial-post templating method is presented for directing block copolymer (BCP) self-assembly to form nanostructures of monolayers and bilayers of microdomains. The topographical post...
9478403 Method and apparatus for a porous electrospray emitter  
An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or...
9478229 Methods and apparatus for recording impulsive sounds  
Loud sounds with fast rise times, like gunfire and explosions, can cause noise-induced hearing loss (NIHL). Unfortunately, current models do not adequately explain how impulsive sounds cause NIHL,...
9476981 Optical phased arrays  
An optical phased array formed of a large number of nanophotonic antenna elements can be used to project complex images into the far field. These nanophotonic phased arrays, including the...
9476768 Two-dimensional fourier transform spectrometer  
The present invention relates to a system and methods for acquiring two-dimensional Fourier transform (2D FT) spectra. Overlap of a collinear pulse pair and probe induce a molecular response which...
9474717 Vaccine nanotechnology  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune...
9474634 Peripheral neural interface via nerve regeneration to distal tissues  
At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a...
US20160307659 Coherent Electron and Radiation Production Using Transverse Spatial Modulation and Axial Transfer  
Coherent electronic current is generated by generating and transmitting an electron bunch along a longitudinal axis. The electron bunch is then directed onto a target, wherein the target imparts a...
US20160307376 HYBRID SENSOR-ENABLED ELECTRIC WHEEL AND ASSOCIATED SYSTEMS, MULTI-HUB WHEEL SPOKING SYSTEMS, AND METHODS OF MANUFACTURING AND INSTALLING WHEEL SPOKES  
Embodiments of hybrid sensor-enabled and autonomous electric wheels can include a plurality of systems and devices integrated into a single compact hub unit that can be retrofitted into numerous...
US20160305939 STOCHASTIC ARRANGEMENT OF REAGENTS IN CLUSTERS - STARC  
The invention, in some aspects relates to compositions and methods for imaging biological systems and physiological activity and conditions in cells.
US20160305856 ITERATIVE EXPANSION MICROSCOPY  
The present invention leverages the techniques for expansion microscopy (ExM) to provide improved high-throughput super-resolution whole-organ imaging methodology to image protein architectures...
US20160304952 IN SITU NUCLEIC ACID SEQUENCING OF EXPANDED BIOLOGICAL SAMPLES  
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy...
US20160304861 SPATIAL MULTIPLEXING FOR MULTISIGNAL CELLULAR IMAGING  
The invention, in some aspects, relates to methods, systems, and components of a high-content, single-cell resolution, spatial multiplex cell imaging system.