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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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8693837 High resolution near field scanning optical microscopy  
An optical fiber including a surface including a non-covalent multilayer including a light-absorbing material can be used to develop fluorescence microscopy with a lateral resolution of about 5 nm...
8692747 LED array with photodetector  
Embodiments of the present invention provide for an array, and corresponding method of forming an array, that includes a plurality of light emitting devices. The light emitting devices are disposed...
8692575 Asynchronous logic automata  
A family of self-timed, charge-conserving asynchronous logic elements that interact with their nearest neighbors permits design and implementation of circuits that are asynchronous at the bit...
8692176 Focal plane array processing method and apparatus  
A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer...
8691464 Three dimensional single-chamber fuel cells  
The present invention relates to single chamber fuel cells and systems and methods associated with the same. Architectures and materials that allow for high performance, enhanced fuel utilization,...
8691203 Method comprising contacting tissue with a cross-linkable polyester prepolymer  
The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a...
8691151 Opto-fluidic architecture for particle manipulation and sorting  
This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to...
8689726 Automated layer by layer spray technology  
The present invention comprises an automated apparatus capable of spray depositing polyelectrolytes via the LbL mechanism with minimal or no human interaction. In certain embodiments, the apparatus...
US20140095003 Electric Vehicle and Method of Battery Set-Point Control  
A method includes utilizing navigation data from a navigation system to segment a route to be travelled by a travelling vehicle into segments each having a road grade different than neighboring...
US20140094399 BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF  
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially ...
US20140094372 COMPACTLY-INTEGRATED OPTICAL DETECTORS AND ASSOCIATED SYSTEMS AND METHODS  
Compactly-integrated electronic structures and associated systems and methods are provided. Certain embodiments relate to the ability to integrate nanowire-based detectors with optical components.
US20140093911 METHOD AND APPARATUS FOR IMAGE-BASED PREDICTION AND SORTING OF HIGH-PERFORMING CLONES  
A method of predictive identification and separation of high-performing cells from a mixed population of cells includes distributing cells belonging to the mixed population to a plurality of open...
US20140093575 STABLE LAYER-BY-LAYER COATED PARTICLES  
Systems and methods for coating a particle core with a layer-by-layer film are disclosed.
US20140091409 APPLICATIONS OF CONTACT-TRANSFER PRINTED MEMBRANES  
The disclosed embodiments provide sensitive pixel arrays formed using solvent-assisted or unassisted release processes. Exemplary devices include detectors arrays, tunable optical instruments,...
US20140090686 METHODS AND APPARATUS FOR CONCENTRATING PHOTOVOLTAICS  
Provided in one embodiment is an article, comprising: a substrate comprising silicon; and a plurality of solar cells disposed over the substrate, wherein at least one of the plurality of the solar...
RE44820 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production  
Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered...
8688438 Generating speech and voice from extracted signal attributes using a speech-locked loop (SLL)  
A speech processing system includes a plurality of signal analyzers that extract salient signal attributes of an input voice signal. A difference module computes the differences in the salient...
8687698 Using multiple transform/subband representations for video encoding  
A method of encoding a sequence of video frames, comprising receiving a sequence of video frames, encoding at least a first portion of the sequence of frames using the first type of...
8685434 Methods and compositions for the treatment of open and closed wound spinal cord injuries  
Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and...
8685323 Virus/nanowire encapsulation within polymer microgels for 2D and 3D devices for energy and electronics  
Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during...
8684595 Systems and methods for structural sensing  
Systems and methods related to the determination of one or more mechanical characteristics of a structural element are generally described. In some embodiments, a mechanical characteristic (e.g., a...
8684189 Multifunctional electroprocessed membranes  
Described is the application of layer-by-layer (LbL) electrostatic assembly techniques to electrospun nanofibers in order to fabricate novel, breathable electrospun fiber-based chemical and...
US20140088729 Powered Ankle-Foot Prosthesis  
A powered ankle-foot prosthesis, capable of providing human-like power at terminal stance that increase amputees metabolic walking economy compared to a conventional passive-elastic prosthesis. The...
US20140087953 Ultra-Light, Magnetically Shielded, High-Current, Compact Cyclotron  
A cyclotron for ion acceleration is magnetically shielded during ion acceleration by passing electrical current in the same direction through both the first and second superconducting primary...
US20140085155 GYROTROPIC METAMATERIAL STRUCTURE  
A gyrotropic metamaterial structure that include a plurality of chiral metamaterials forming one or more pairs of dipole structures. A plurality of lumped circuits are positioned between the one or...
8681837 Digital Transmitter  
An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to...
8680303 Epoxidation catalysts  
The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may...
8679782 Production of triacylglycerides, fatty acids, and their derivatives  
The invention relates to production of triacylglycerols in cells.
8678075 Heat exchangers and related methods  
Heat exchanger. The heat exchanger includes a thermal contact plate defining a cavity in fluid communication with a first pipe and a plurality of stationary elements substantially perpendicular to...
8677949 Fuel management system for very high efficiency flex fuel engines powered by methanol and gasoline  
Turbocharged or supercharged spark ignition engine. The engine includes a source of methanol for direct injection of methanol into the engine and for delivering a portion of the methanol to a...
US20140080913 Sensory-Specific Local Anesthesia and Prolonged Duration Local Anesthesia  
Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block is greatly prolonged by combining...
US20140080841 Chemical Permeation Enhancers Enhance Nerve Blockade by Toxins  
Chemical permeation enhancers (CPEs) improve access of local anesthetics to the nerve, thereby improving their performance. Surfactants, representing three CPE sub-groups: anionic, cationic, and...
US20140080775 MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant ...
US20140080766 COMPOSITIONS AND METHODS FOR MACROMOLECULAR DRUG DELIVERY  
The present invention features compositions and methods for delivering a therapeutic agent to the cytoplasm of a cell. We have developed, inter alia, a system in which two or more distinct...
US20140080698 BIOTEMPLATED INORGANIC MATERIALS  
A method of making a metal oxide nanoparticle comprising contacting an aqueous solution of a metal salt with an oxidant. The method is safe, environmentally benign, and uses readily available...
US20140080122 Optical Nanosensors Comprising Photoluminescent Nanostructures  
Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a...
US20140079776 Nanostructures for Drug Delivery  
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the...
US20140077273 MECHANICAL MEMORY TRANSISTOR  
A mechanical memory transistor includes a substrate having formed thereon a source region and a drain region. An oxide is formed upon a portion of the source region and upon a portion of the drain...
8674576 Electropermanent magnet-based motors  
An electropermanent magnet-based motor includes a stator having at least one electropermanent magnet, at least one coil around the electropermanent magnet configured to pass current pulses that...
8673591 Genetic incorporation of 3-aminotyrosine into reductases  
This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino...
8673267 Methods and products for in vivo enzyme profiling  
The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed...
US20140074408 IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS  
A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database...
US20140074253 SCAFFOLDS COMPRISING NANOELECTRONIC COMPONENTS FOR CELLS, TISSUES, AND OTHER APPLICATIONS  
The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires...
US20140073053 METHODS FOR TRANSFECTING CELLS WITH NUCLEIC ACIDS  
The present disclosure provides culture media and methods of using culture media for efficient transfection of a target cell with nucleic acid molecules. The media is capable of supporting cells in...
US20140072229 Complex-Valued Phase-Based Eulerian Motion Modulation  
In one embodiment, a method of amplifying temporal variation in at least two images includes converting two or more images to a transform representation. The method further includes, for each...
US20140072228 Complex-Valued Eulerian Motion Modulation  
In one embodiment, a method of amplifying temporal variation in at least two images includes converting two or more images to a transform representation. The method further includes, for each...
US20140072190 Linear-Based Eulerian Motion Modulation  
In one embodiment, a method of amplifying temporal variation in at least two images comprises examining pixel values of the at least two images. The temporal variation of the pixel values between...
US20140070228 SEMICONDUCTOR DEVICES HAVING A RECESSED ELECTRODE STRUCTURE  
An electrode structure is described in which conductive regions are recessed into a semiconductor region. Trenches may be formed in a semiconductor region, such that conductive regions can be...
US20140070167 Solid State Cloaking for Electrical Charge Carrier Mobility Control  
An electrical mobility-controlled material includes a solid state host material having a controllable Fermi energy level and electrical charge carriers with a charge carrier mobility. At least one...
US20140069723 METHOD AND APPARATUS FOR PENETRATING PARTICULATE SUBSTRATES  
A method or corresponding apparatus in an example embodiment of the present invention relates to penetrating a particulate substrate using a compact, lightweight, low-energy, reversible, and...