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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20140348857 METHODS OF DIAGNOSIS AND TREATMENT OF ENDOPLASMIC RETICULUM (ER) STRESS-RELATED CONDITIONS  
The present invention relates to methods for treating endoplasmic reticulum (ER) stress-related conditions (e.g., cancer, protein folding/misfolding disease, diabetes mellitus) and for identifying...
US20140348820 IMMUNOGLOBULINS WITH REDUCED AGGREGATION  
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such...
US20140348203 STABLE NANOCRYSTALLINE ORDERING ALLOY SYSTEMS AND METHODS OF IDENTIFYING SAME  
Provided in one embodiment is a method of identifying a stable phase of an ordering binary alloy system comprising a solute element and a solvent element, the method comprising: determining at...
US20140347676 Methods and Apparatus for Imaging of Occluded Objects  
An active imaging system, which includes a light source and light sensor, generates structured illumination. The light sensor captures transient light response data regarding reflections of light...
US20140346615 ENHANCEMENT-MODE TRANSISTORS WITH INCREASED THRESHOLD VOLTAGE  
A field effect transistor that has a source, a drain, a gate, a semiconductor region, and a dielectric region. The dielectric region is located between the semiconductor region and the gate....
US20140346197 SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT USING MECHANICAL ADVANTAGE  
Devices and methods for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir configured to contain a fluid, a first actuator...
US20140345348 ALKALI METAL ION SOURCE WITH MODERATE RATE OF ION RELEASE AND METHODS OF FORMING  
An alkali metal ion source with a moderate rate of release of the ion (e.g. potassium) is formed by a method that includes: 1) combining an particulate ore that contains at least one of an alkali...
8895721 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
8895718 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
8895308 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8894891 Copolymer-associated nanomaterial  
A nanomaterial can include an outer layer including a ligand. The ligand can include a first monomer unit including a first moiety having affinity for a surface of the nanocrystal, a second monomer...
8894679 Surgical puncture access with preload lock  
A surgical device mitigates over-puncture with a bias spring that biases a leading, cutting edge in the opposite direction of the anticipated over-puncture. An associated locking mechanism is...
8894088 Methods and apparatus for folding vehicle chassis  
In exemplary implementations of this invention, a foldable vehicle has a foldable chassis. The wheelbase (and thus the overall footprint) of the vehicle can be reduced when parking, and can be...
US20140343825 FUEL MANAGEMENT SYSTEM FOR VARIABLE ETHANOL OCTANE ENHANCEMENT OF GASOLINE ENGINES  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
US20140343495 SYSTEMS AND METHODS FOR DELIVERING DRUGS  
A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The...
US20140343139 COMPOSITIONS, METHODS, AND KITS COMPRISING PLATINUM COMPOUNDS ASSOCIATED WITH A LIGAND COMPRISING A TARGETING MOIETY  
Compositions, kits, and methods for treatment of cancers are generally provided. In some embodiments, the compositions, kits, and methods comprise a platinum (e.g., Pt(II) or Pt(IV)) compound...
US20140342247 Flexible and Implantable Glucose Fuel Cell  
A glucose fuel cell for reception into a given constrained volume of implantation in a vertebrate in which the glucose fuel cell has access to fluid containing glucose. The fuel cell includes an...
US20140341838 Biocompatible Adhesive Materials and Methods  
Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive...
US20140340569 Methods and apparatus for multi-frequency camera  
In exemplary implementations of this invention, a multi-frequency ToF camera mitigates the effect of multi-path interference (MPI), and can calculate an accurate depth map despite MPI. A light...
US20140340502 METHODS AND APPARATUS FOR REFRACTIVE FLOW MEASUREMENT WITH THREE DIMENSIONS AND UNCERTAINTY  
An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video...
US20140340085 TIME-RESOLVED MAGNETIC SENSING WITH ELECTRONIC SPINS IN DIAMOND  
A system for performing Walsh reconstruction of time dependent fields with a quantum probe that includes a diamond structure that includes nitrogen-vacancy (NV) centers for sensing magnetic and...
US20140339918 Enhanced Stacked Switched Capacitor Energy Buffer Circuit  
A stacked switched capacitor (SSC) energy buffer circuit includes a switching network and a plurality of energy storage capacitors. The switching network need operate at only a relatively low...
8891593 Peaky binning relaying scheme for wideband/low signal-to-noise ratio (SNR) wireless communications  
A method, apparatus and computer program product for a peaky binning Relaying Scheme for Wideband/Low Signal-To-Noise Ratio (SNR) Wireless Communications is presented. In a computer system having a...
8891575 Optical feedback structures and methods of making  
An optical resonator can include an optical feedback structure disposed on a substrate, and a composite including a matrix including a chromophore. The composite disposed on the substrate and in...
8889857 Phosphine-ligated palladium sulfonate palladacycles  
Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described...
8889747 Fischer Tropsch reactor with integrated organic rankine cycle  
A process for recovering heat uses a product stream from a Fischer Tropsch synthesis reactor as the coolant in the same Fischer Tropsch reactor. This stream is then used as the working fluid in an...
8889418 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8889221 Method for reducing pressure drop through filters, and filter exhibiting reduced pressure drop  
Methods for generating and applying coatings to filters with porous material in order to reduce large pressure drop increases as material accumulates in a filter, as well as the filter exhibiting...
US20140336789 CONTROLLING DYNAMICAL SYSTEMS WITH BOUNDED PROBABILITY OF FAILURE  
A computer-based method controls a dynamical system in an uncertain environment within a bounded probability of failure. The dynamical system has a state space and a control space. The method...
US20140336178 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES  
The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one...
US20140336039 ANTI-FINGERPRINT PHOTOCATALYTIC NANOSTRUCTURE FOR TRANSPARENT SURFACES  
Titania-based porous nanoparticle coatings are mechanically robust, with low haze, which exhibit short time scales for decomposition of fingerprint oils under ultraviolet light. The mechanism by...
US20140335620 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
US20140335504 HUMAN ADAPTATION OF H5 INFLUENZA  
The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also...
US20140332462 FLUX-ENHANCED HIERARCHICAL POROUS MEMBRANE FOR OIL-WATER NANOEMULSION SEPARATION  
Hierarchical porous membranes suitable for use in oil/water separation processes are provided. The membranes described herein are particularly well suited for separating trace amounts of water...
US20140332386 Method of Building Massively-Parallel Ion Concentration Polarization Separation Device  
Ion Concentration Polarization (ICP) purification devices and methods for building massively-parallel implementations of the same, said devices being suitable for separation of salts, heavy metals...
8886049 Filter-based DPSK communications system  
A filter-based method of demodulating differentially encoded phase shift keyed (DPSK) optical signals, such as commonly used binary-DPSK (DBDPSK) and quadrature DPSK (DQPSK) signals, that can...
8885926 Image and data segmentation  
Approaches to segmentation or detection of objects and their boundaries in images (or other data sets) do not rely on machine learning approaches that aim to minimize pixel-level agreement between...
8884234 Portable directional device for locating neutron emitting sources  
An apparatus for determining a direction of travel of a neutron emitted from a source includes: a chamber containing (i) nuclei that recoil upon interaction with an incoming neutron and (ii) atoms...
8883962 Zinc-responsive peptides, and methods of use thereof  
Described herein are compounds and methods useful in the detection of, e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds,...
8883047 Thermoelectric skutterudite compositions and methods for producing the same  
Compositions related to skutterudite-based thermoelectric materials are disclosed. Such compositions can result in materials that have enhanced ZT values relative to one or more bulk materials from...
US20140330018 METATHESIS CATALYSTS AND METHODS THEREOF  
The present application provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I. In some...
US20140329884 1,3,5-TRIAZINANE-2,4,6-TRIONE DERIVATIVES AND USES THEREOF  
The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds....
US20140329002 COMPOSITIONS COMPRISING ENHANCED GRAPHENE OXIDE STRUCTURES AND RELATED METHODS  
Embodiments described herein generally relate to compositions comprising a graphene oxide species. In some embodiments, the compositions advantageously have relatively high oxygen content, even...
US20140328931 NUCLEIC ACID PARTICLES, METHODS AND USE THEREOF  
The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to...
US20140327439 STABLE THREE-AXIS NUCLEAR SPIN GYROSCOPE  
An n-NV-based gyroscope is provided that includes a diamond structure implanted with a plurality of NV centers, whose nuclear spins form a spin gyroscope. A number of radio-frequency (rf) coils and...
US20140326866 METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY  
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design...
US20140326849 Superelastic Alloy Structural Geometry for Ultrahigh Mechanical Damping  
A mechanical structure is provided with a crystalline superelastic alloy that is characterized by an average grain size and that exhibits a martensitic phase transformation resulting from a...
US20140326007 COMPOSITIONS AND METHODS COMPRISING POROUS METAL ORGANIC FRAMEWORKS AND RELATED USES  
Compositions and methods comprising metal organic frameworks (MOFs) and related uses are generally provided. In some embodiments, an MOF comprises a plurality of metal ions, each coordinated with...
US20140325827 CONTROLLED INTER-MODE CROSS-TALK IN OPTICAL WAVEGUIDES  
Techniques and devices are disclosed to provide controlled inter-mode cross-talk in multimode optical waveguides. The structure of a bent multimode optical waveguide can be designed or configured...