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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20140300211 Discrete Motion System  
Discrete motion systems move relative to a lattice, using bistable mechanisms to snap between lattice locations. A discrete motion system includes a lattice having a regular configuration of...
US20140299538 Antifouling and Chlorine-Resistant Ultrathin Coatings on Reverse Osmosis Membranes  
Disclosed are methods of preparing antifouling and chlorine-resistant coatings on reverse osmosis membranes with initiated chemical vapor deposition. The coatings enhance the stability and lifetime...
US20140298945 MODULAR ANGULAR-MOMENTUM DRIVEN MAGNETICALLY CONNECTED ROBOTS  
A modular robotic system that includes a plurality of self-configuring robots. Each self-configuring robot includes a frame structure having a plurality of cylindrical bonding magnets positioned...
US20140298811 THERMAL PULSE ENERGY HARVESTING  
A device for thermal energy harvesting can use pulsed heat.
RE45176 Tactile sensor using elastomeric imaging  
A tactile sensor includes a photosensing structure, a volume of elastomer capable of transmitting an image, and a reflective skin covering the volume of elastomer. The reflective skin is...
8853384 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
8852807 Conductive lithium storage electrode  
A compound comprising a composition Ax(M′1−aM″a)y(XD4)z, Ax(M′1−aM″a)y(DXD4)z, or Ax(M′1−aM″a)y(X2D7)z, (A1−aM″a)xM′y(XD4)z, (A1−aM″a)xM′y(DXD4)z, or (A1−aM″a)xM′y(X2D7)z. In the ...
US20140296724 Method and Apparatus for Predicting Patient Outcomes from a Physiological Segmentable Patient Signal  
A method and apparatus for predicting patient outcome from a physiological segmentable signal of a patient. In one embodiment, the method comprises the steps of obtaining the physiological...
US20140295166 SYSTEMS AND METHODS FOR GROWTH OF NANOSTRUCTURES ON SUBSTRATES, INCLUDING SUBSTRATES COMPRISING FIBERS  
Systems and methods for the formation of nanostructures, including carbon-based nanostructures, are generally described. In certain embodiments, substrate configurations and associated methods are...
US20140294729 METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS  
The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and...
US20140291420 ARTICLES FOR MANIPULATING IMPINGING LIQUIDS AND METHODS OF MANUFACTURING SAME  
This invention relates generally to an article that includes a non-wetting surface having a dynamic contact angle of at least about 90°. The surface is patterned with macro-scale features ...
US20140290763 Controllable Normal Force Mechanism with Minimum Energy Consumption  
Force control system. The system includes a first pair of permanent magnets for providing a normal force on the wheel of a robot adapted for n-pipe inspections. A second pair of magnets is provided...
US20140290699 ARTICLES AND METHODS PROVIDING LIQUID-IMPREGNATED SCALE-PHOBIC SURFACES  
This invention relates generally to articles, devices, and methods for inhibiting or preventing the formation of scale during various industrial processes. In certain embodiments, a vessel is...
US20140290596 Reformer Enhanced Alcohol Engine  
Reformer-enhanced alcohol engine system. The engine system includes a spark-ignited alcohol engine having a compression ratio in the range of 13-15 and includes a turbocharger or supercharger...
8848199 Tomographic phase microscopy  
The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser...
8848006 Tensor displays  
In exemplary implementations of this invention, an automultiscopic display device includes (1) one or more spatially addressable, light attenuating layers, and (2) a controller which is configured...
8847637 Time-interleaved multi-modulus frequency divider  
Described are a multi-modulus frequency divider and event counter that are based on time-interleaved signals generated from a received signal. For the frequency divider, each time-interleaved clock...
8847068 Compositions, methods, and systems comprising poly(thiophenes)  
The present invention generally relates to compositions comprising at least one poly(thiophene) and an n-type material. The compositions can be used in a variety of applications, for example, in...
8846363 Compositions of and methods of using sulfatases from Flavobacterium heparinum  
This invention is related, in part, to sulfatase enzymes and methods of their use.
8846190 Inorganic nanowires  
Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the...
8846098 Artificial cell constructs for cellular manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
8845526 Integrated otoscope and three dimensional scanning system  
A multi-purpose device that can be used, as, among other things, an otoscope and a three dimensional scanning system is disclosed.
US20140288440 SYSTEMS AND METHODS FOR QUANTITATIVE CAPNOGRAM ANALYSIS  
Systems and methods are disclosed herein for quantitatively identifying a patient's physiological state based on one or more capnograms. One or more capnograms are acquired, each capnogram being...
US20140287997 USE OF GROWTH HORMONE OR GROWTH HORMONE RECEPTOR AGONISTS TO PREVENT OR TREAT STRESS-SENSITIVE PSYCHIATRIC ILLNESS  
The invention relates to methods for treating stress sensitive condition, particularly depression. For instance a subject having or at risk of having a stress-sensitive condition such as depression...
US20140287938 RECOMBINANT VIRUS AND PREPARATIONS THEREOF  
The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making...
US20140287509 Intracellular Delivery  
A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass...
US20140287150 CONDENSATION ON SURFACES  
A uniform external field can enhance condensation on a superhydrophobic surface. Jumping droplets on superhydrophobic surfaces accumulate a positive charge which promises the manipulation and...
US20140285084 SELF-ALIGNED GATED EMITTER TIP ARRAYS  
Methods for fabrication of self-aligned gated tip arrays are described. The methods are performed on a multilayer structure that includes a substrate, an intermediate layer that includes a...
8841818 Piezoelectric electromechanical devices  
An piezoelectric electromechanical transistor has first and second terminals formed in a semiconductor region, a gate and a piezoelectric region between the gate and the semiconductor region. The...
8841346 Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders  
The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by...
8841152 Method of lift-off patterning thin films in situ employing phase change resists  
Method for making a patterned thin film of an organic semiconductor. The method includes condensing a resist gas into a solid film onto a substrate cooled to a temperature below the condensation...
US20140280454 Method and Apparatus for Implementing Distributed Content Caching In A Content Delivery Network  
Distributed content caching is implemented in an efficient, low cost manner within a content delivery network (CDN). In various embodiments, content is identified for caching at a number of gateway...
US20140280395 Network Coded Storage With Multi-Resolution Codes  
Multi-resolution encoded files are stored on a plurality of disk drives using systematic network coded storage. In some embodiments, the stored files are used to provide video streaming services...
US20140275555 ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS  
Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g.,...
US20140275481 SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS  
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that...
US20140274988 DUAL TARGETING ANTICANCER AGENTS  
Methods, compounds, and compositions for treating a proliferative disorder or other physiological conditions via a dual targeting anticancer therapy are provided. In some embodiments, a dual...
US20140274900 USE OF ANTAGONISTS OF GROWTH HORMONE OR GROWTH HORMONE RECEPTOR TO PREVENT OR TREAT STRESS-SENSITIVE PSYCHIATRIC ILLNESS  
The invention relates to methods for treating stress sensitive condition. For instance a subject having or at risk of having a stress-sensitive condition may be treated with a growth hormone (GH)...
US20140273255 RARE EARTH SPATIAL/SPECTRAL BARCODES FOR MULTIPLEXED BIOCHEMICAL TESTING  
Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals...
US20140273246 RARE EARTH SPATIAL/SPECTRAL MICROPARTICLE BARCODES FOR LABELING OF OBJECTS AND TISSUES  
Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission...
US20140273234 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
US20140273232 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20140273231 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20140273209 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140272411 High-Pressure In-Fiber Particle Production With Precise Dimensional Control  
Herein is provided a fiber that includes a cladding material disposed along a longitudinal-axis fiber length and a plurality of discrete and disconnected high-stress domains that are disposed as a...
US20140271843 Multi-Layer Hydrogel Capsules for Encapsulation of Cells and Cell Aggregates  
Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after...
US20140271827 LIPID VESICLE COMPOSITIONS AND METHODS OF USE  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
US20140271602 NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS  
The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the...
US20140271601 CROSSLINKABLE TREHALOSE FOR THE COVALENT INCORPORATION IN HYDROGELS AND METHODS OF USE  
Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.
US20140271325 SINTERED NANOCRYSTALLINE ALLOYS  
Provided in one embodiment is a method, comprising: sintering a plurality of nanocrystalline particulates to form a nanocrystalline alloy, wherein at least some of the nanocrystalline particulates...
US20140269879 DIGITAL TRANSMITTER  
An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to...