Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20170352771 Systems, Methods, and Apparatus for Concentrating Photovoltaic Cells  
A photovoltaic (PV) apparatus includes a substrate having a first substrate surface and a second substrate surface. A cavity fabricated in the substrate extends from the first substrate surface...
US20170352538 Systems and Methods for Fabricating Single-Crystalline Diamond Membranes  
A buffer layer is employed to fabricate diamond membranes and allow reuse of diamond substrates. In this approach, diamond membranes are fabricated on the buffer layer, which in turn is disposed...
US20170351293 Apparatus and Methods for Optical Neural Network  
An optical neural network is constructed based on photonic integrated circuits to perform neuromorphic computing. In the optical neural network, matrix multiplication is implemented using one or...
US20170349950 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF  
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell...
US20170349914 DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF CRISPR SYSTEMS AND COMPOSITIONS FOR GENOME EDITING AS TO HEMATOPOIETIC STEM CELLS (HSCs)  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20170349894 ESCORTED AND FUNCTIONALIZED GUIDES FOR CRISPR-CAS SYSTEMS  
The present invention generally relates to CRISPR systems or complexes, such as those with an escorted guide RNA.
US20170349884 Production of Differentiated Enteroendocrine Cells and Insulin Producing Cells  
A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a...
US20170349650 IMMUNOGLOBULINS WITH REDUCED AGGREGATION  
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such...
US20170348431 DRUG DELIVERY POLYMERS AND USES THEREOF  
Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are...
US20170348176 High Performance Free Rolling Cable Transmission  
A mechanical transmission, tethered actuation system, an autonomous ankle exoskeleton design and method of their use employing a cable, pulleys and associated pulley housings to change angular...
9839073 Multifunctional CNT-engineered structures  
Various applications for structured CNT-engineered materials are disclosed herein. In one application, systems are disclosed, wherein a structured CNT-engineered material forms at least part of an...
9837953 Metallic dielectric photonic crystals and methods of fabrication  
A metallic-dielectric photonic crystal is formed with a periodic structure defining a plurality of resonant cavities to selectively absorb incident radiation. A metal layer is deposited on the...
9837237 Pyrolyzed porous carbon materials and ion emitters  
Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described.
9835885 Systems, methods, and apparatus for sensitive thermal imaging  
The high-pixel-count uncooled thermal imaging arrays disclosed herein have liquid crystal (LC) microcavity transducers separate from the read-out integrated circuit (ROIC). The transducer converts...
9835363 Evaporative heat transfer system  
Evaporative heat transfer system. The system includes a substrate and a plurality of substantially parallel, spaced-apart ridges extending from the substrate forming vertical liquid manifolds...
9834747 Methods and apparatus for transplantation of nucleic acid molecules  
In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some...
US20170346283 Systems and Methods for Modular DC Microgrids with Control of Loads  
The systems and methods described herein are directed towards a microgrid having modular power management units to control and regulate power to maintain a stable energy environment and provide...
US20170344699 WATER-SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF  
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
US20170343553 CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
US20170342077 DIAZENE DIRECTED MODULAR SYNTHESIS OF COMPOUNDS WITH QUATERNARY CARBON CENTERS  
Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are...
US20170341316 COMPOSITE ARTICLES COMPRISING NON-LINEAR ELONGATED NANOSTRUCTURES AND ASSOCIATED METHODS  
The present disclosure relates to composite articles comprising non-linear elongated nanostructures and associated systems and methods. In certain embodiments, collections of carbon nanotubes or...
US20170341034 GRAPHENE OXIDE MEMBRANES AND RELATED METHODS  
Membranes comprising graphene oxide sheets and associated filter media and methods are provided. In some embodiments, a membrane may comprise graphene oxide sheets that have undergone one or more...
US20170341010 COMPOSITIONS COMPRISING METAL ORGANIC FRAMEWORKS FOR THE UPTAKE OF COMPOUNDS AND RELATED METHODS  
Compositions and methods for adsorption of a species (e.g., ammonia, water, a halogen) comprising metal organic frameworks (MOFs) are generally provided. In some embodiments, a MOF comprises a...
9831722 Wireless non-radiative energy transfer  
Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a...
9831682 Efficient near-field wireless energy transfer using adiabatic system variations  
Disclosed is a method for transferring energy wirelessly including transferring energy wirelessly from a first resonator structure to an intermediate resonator structure, wherein the coupling rate...
9829728 Method for forming magneto-optical films for integrated photonic devices  
Methods for forming magneto-optical films for integrated photonic devices and integrated photonic devices incorporating same are described. An optical isolator or any nonreciprocal photonic...
9829379 Two-dimensional spectroscopy system and two-dimensional spectroscopic analysis method  
A two-dimensional (2D) spectroscopy system and a 2D spectroscopic analysis method are disclosed. The 2D spectroscopy system includes: a light transmission delayer configured for forming a...
9828251 Silica aerogels and their preparation  
Silica aerogels with improved properties are disclosed together with methods for synthesizing such aerogels. The improved properties include lower thermal conductivity (better insulating...
9827007 Tissue collection needle  
A tissue collection needle with a hollow interior provides two opposing tips with beveled edges on facets that drive tissue toward the hollow interior where the tissue can be gathered and severed...
US20170339431 System and Method for Providing Real-Time Super-Resolution for Compressed Videos  
A real-time system and method for displaying video on a display are disclosed. Received compressed video data is decoded to produce an uncompressed first video frame, a first frame syntax element,...
US20170338943 DNA ENCRYPTION TECHNOLOGIES  
In some aspects, the instant disclosure relates to the multiplexed encryption of information on nucleic acid molecules. In some aspects, the instant disclosure relates to a method of secure...
US20170338122 Methods and Apparatus for Variable Selectivity Atomic Layer Etching  
A method of fabricating a microelectronic device, such as a high electron mobility transistors (HEMT), is disclosed. In some examples, the method comprises placing a masked semiconductor sample...
US20170336482 Systems, Apparatus, and Methods of Nonlinear Terahertz (THz) Magnetic Resonance Measurement  
A nonlinear terahertz (THz) spectroscopy technique uses a sample illuminated by two THz pulses separately. The illumination generates two signals BA and BB, corresponding to the first and second...
US20170336102 Enhanced Thermal Stability on Multi-Metal Filled Cermet Based Spectrally Selective Solar Absorbers  
A spectrally selective solar absorber is described and comprises a substrate, double cermet layers comprising multi-metal nanoparticles embedded in a dielectrics matrix, and double antireflection...
US20170335411 CORRECTING CROSSTALK IN BIOLOGICAL SYSTEMS  
Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.
US20170335406 METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS  
Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
US20170335334 DNA CLOAKING TECHNOLOGIES  
The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid...
US20170333887 CATALYSTS FOR METATHESIS REACTIONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS  
The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical...
US20170333405 CONVERGENT AND ENANTIOSELECTIVE TOTAL SYNTHESIS OF COMMUNESIN ANALOGS  
A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I): or a pharmaceutically...
US20170333348 MASS PRODUCTION AND SIZE CONTROL OF NANOPARTICLES THROUGH CONTROLLED MICROVORTICES  
Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such...
US20170333304 Hydrogel Particles, Compositions, and Methods  
Hydrogel particles are provided that include a crosslinked polymer and a drug conjugated to the crosslinked polymer. The hydrogel particles may include a pH sensitive moiety and a redox sensitive...
US20170332933 DEEP BRAIN SOURCE IMAGING WITH M/EEG AND ANATOMICAL MRI  
A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from...
9825659 Digital matching of a radio frequency antenna  
A matching technique that may be used with electrically small antennas uses one or more digital circuit blocks connected in a feedback arrangement configured to tune the transfer function response...
9825545 Switched-capacitor split drive transformer power conversion circuit  
A split drive transformer (SDT) and use of such a transformer in a power converter is described. The power converter includes a power and distributor circuit configured to receive one or more...
9823250 Crystal structures of human Torsin-A and methods of determining and using the same  
A protein composition including TorsinA or TorsinA mutant, LULL1, and a nanobody obtained by immunization using TorsinA and LULL1 is used to grow complex crystals, and three dimensional structures...
9822467 Methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species  
The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In...
9822372 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
9821042 Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness  
The invention relates to methods of protecting against chronic stress in a subject and treating stress sensitive disorders in a subject by antagonizing ghrelin or ghrelin receptor.
9820636 Layered medium for three-dimensional imaging  
The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums,...
US20170331990 Methods and Apparatus for Optical Fiber Imaging  
An open-ended, incoherent bundle of optical fibers transmits light from a nearby scene. A camera captures images of the back end of the fiber bundle. Because the fiber bundle is incoherent, the...