Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20160293858 OPTOELECTRIC DEVICES FABRICATED WITH DEFECT TOLERANT SEMICONDUCTORS  
Using fundamental electronic structure properties as an indicative of defect tolerance, a broad class of semiconductors containing partially oxidized cations can be identified, as well as several...
US20160290980 DETECTION OF AMINES  
A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a complex, and the complex can include a carbon nanotube that...
US20160289248 ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS  
Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g.,...
US20160289173 DEVICES AND METHODS FOR CRYSTALLIZING A COMPOUND  
The present invention generally relates to devices and methods for crystallizing a compound. In certain industries, crystallization techniques require additional filtration steps in order to...
US20160287870 LOW POWER COCHLEAR IMPLANTS  
In one aspect, the disclosure features systems for providing auditory signals to a subject. The systems include a sensor front-end circuit configured to be connected to an acoustic sensor and to...
US20160287622 COMPOSITIONS AND METHODS FOR TREATING IMMUNE AND VIRAL DISORDERS AND MODULATING PROTEIN-RNA INTERACTION  
The present invention relates to methods of treating or decreasing the likelihood of developing a disorder associated with immune misregulation, such as, an autoimmune disorder, or viral or...
9459222 Methods for deposition of materials including mechanical abrasion  
Methods described herein may be useful in the fabrication and/or screening of devices (e.g., sensors, circuits, etc.) including conductive materials. In some embodiments, a conductive material is...
9459024 Localized solar collectors  
A localized heating structure, and method of forming same, for use in solar systems includes a thermally insulating layer having interconnected pores, a density of less than about 3000 kg/m3, and...
9458989 Methods and apparatus for transparent display using up-converting nanoparticles  
Disclosed herein are transparent color displays with nanoparticles made with nonlinear materials and/or designed to exhibit optical resonances. These nanoparticles are embedded in or hosted on a...
9458509 Multiple input biologic classifier circuits for cells  
Provided herein are high-input detector modules and multi-input biological classifier circuits and systems that integrate sophisticated sensing, information processing, and actuation in living...
9458489 Microfluidics sorter for cell detection and isolation  
A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels...
9458472 Detection and destruction of cancer cells using programmed genetic vectors  
In its various embodiments, the invention provides, first, a composition comprising a vector for transfecting a cell. The vector comprises a first nucleic acid encoding an antisense agent having...
9458357 ph-sensitive sacrificial materials for the microfabrication of structures  
Methods for microfabricating composite materials and composite materials prepared there from are described herein. The sacrificial material can be etched or patterned to create a two-dimensional...
9457128 Scaffolds comprising nanoelectronic components for cells, tissues, and other applications  
The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires...
9457047 Immunomodulating compositions and methods of use thereof  
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of...
9456800 Ultrasound scanning system  
A force-controlled ultrasound imaging device uses a linear drive system to maintain a suitable contact force with a subject. A combination of hardware and software limits on travel for the linear...
US20160285650 METHODS AND APPARATUS FOR MONITORING OCCUPANCY OF WIDEBAND GHz SPECTRUM AND SENSING AND DECODING RESPECTIVE FREQUENCY COMPONENTS OF TIME-VARYING SIGNALS USING SUB-NYQUIST CRITERION SIGNAL SAMPLING  
Methods and apparatus for monitoring wideband GHz spectrum for wireless communication, and sensing and decoding respective frequency components of a time-varying signal corresponding to the...
US20160285007 ORGANIC CONDUCTIVE MATERIALS AND DEVICES  
Embodiments described herein relate to compositions including bridged bicyclic compounds such as iptycene-based structures and extended iptycene structures. In some embodiments, the compositions...
US20160284811 ELECTRONICS INCLUDING GRAPHENE-BASED HYBRID STRUCTURES  
Device are described that include a semiconductor material layer and at least one graphene-based electrode disposed over a portion of the semiconductor material layer, such that the at least one...
US20160281072 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
US20160280827 POLYMERS, HYDROGELS, AND USES THEREOF  
Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties...
US20160280693 ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF  
The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically...
US20160279630 Methods and Apparatus for Pipetting  
A pipetting system identifies and records data regarding pipetting events, including the time and well into which a pipette dispenses liquid and the volume of liquid dispensed into the well. The...
US20160279246 METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION  
Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the...
9455114 Systems and methods for particle pulse modulation  
Methods and apparatus for modulating a particle pulse include a succession of Hermite-Gaussian optical modes that effectively construct a three-dimensional optical trap in the particle pulse's...
9452198 Lectin conjugates for mucin hydration  
The invention provides, inter alia, conjugates of a hydratable polymer (such as PEG, polyethylene glycol) and a lectin (such as wheat germ agglutinin, WGA), compositions comprising these...
9451979 Method and apparatus for grafting of skin tissue  
Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality...
US20160277893 SUB-DECIMETER RADIO FREQUENCY RANGING  
A system enables a single WiFi access point to localize clients to within tens of centimeters. Such a system can bring indoor positioning to homes and small businesses which typically have a...
US20160272965 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF  
The present invention generally relates to libraries, compositions, methods, applications, kits and screens used in functional genomics that focus on gene function in a cell and that may use...
US20160272623 FORMATION OF MACROMOLECULES USING ITERATIVE GROWTH AND RELATED COMPOUNDS  
In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units...
US20160271518 Multi-Stage Bubble-Column Vapor Mixture Condenser and HDH System  
A multi-stage bubble-column vapor mixture condenser comprises at least a first stage and a second stage. Each stage includes a carrier-gas inlet and a carrier-gas outlet, as well as a condenser...
9451177 Methods and apparatus for high speed camera  
In exemplary implementations of this invention, a camera can capture multiple millions of frames per second, such that each frame is 2D image, rather than a streak. A light source in the camera...
9451141 Methods and apparatus for demultiplexing illumination  
In illustrative implementations of this invention, an imaging system includes multiple light sources that illuminate a scene, and also includes a lock-in time of flight camera. While the scene is...
9450506 Apparatus for multi-level switched-capacitor rectification and DC-DC conversion  
A voltage-step down rectifier topology suitable for integration on a die of an integrated circuit is described. In one embodiment, a switched capacitor rectifier is provided having an architecture...
9450422 Wireless energy transfer  
Disclosed is an apparatus for use in wireless energy transfer, which includes a first resonator structure configured to transfer energy non-radiatively with a second resonator structure over a...
9450421 Wireless non-radiative energy transfer  
Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a...
9450053 Photonic integrated circuits based on quantum cascade structures  
Photonic integrated circuits (PICs) are based on quantum cascade (QC) structures. In embodiment methods and corresponding devices, a QC layer in a wave confinement region of an integrated...
9449142 System and method for modeling supervisory control of heterogeneous unmanned vehicles through discrete event simulation  
A system and method for modeling supervisory control of heterogeneous unmanned vehicles through discrete event simulation is provided. Generally, the system contains a memory and a processor...
9448219 Electro-mechanical switches and methods of use thereof  
One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain...
9448066 Methods and apparatus for jammable HCI interfaces  
In exemplary implementations of this invention, a jammable structure functions as an HCI interface. A user provides input by changing the shape of a flexible layer of the jammable structure (e.g.,...
9448061 Selecting an earpiece based on dynamic data  
The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums,...
9448060 Methods and apparatus for imaging of occluded objects  
An active imaging system, which includes a light source and light sensor, generates structured illumination. The light sensor captures transient light response data regarding reflections of light...
9447378 Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes  
The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such...
9447129 Suprametallogels and uses thereof  
The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and...
9447030 Inhibitors of histone deacetylase  
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described...
9446585 Methods and apparatus for handheld inkjet printer  
A handheld inkjet printer includes an inkjet print head and a tip. One or more sensors measure the position of points on a curved surface that are physically touched by the tip while the tip is...
9446394 Z-selective ring-closing metathesis reactions  
The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.
9446031 Compositions and methods for neovascularization  
The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents...
9445994 Lipid vesicle compositions and methods of use  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
US20160270204 Phase-Lock Loop Synchronization Between Beam Orbit And RF Drive In Synchrocyclotrons  
The invention specifies the use of feedback in the radio frequency (RF) drive for a synchrocyclotron, controlling the phase and/or amplitude of the accelerating field as a means to assure optimal...