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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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8709483 System for targeted delivery of therapeutic agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
8708965 Scalable parallel gene therapy injector array  
A scalable parallel injector array has a support structure for holding injector tubes in a spatial pattern in order to enable delivery of fluidic materials simultaneously to a group of specific...
8708923 Wearable system for monitoring physiological signals  
A wearable system for monitoring a plurality of physiological signals is provided. The wearable system includes at least one sensor producing the physiological signals associated with a patient. A...
8708696 Swirl-counter-swirl microjets for thermoacoustic instability suppression  
Combustor. The combustor includes an axially symmetric tube along with means for introducing fuel and air into the tube. A swirler is disposed within the tube to impart rotation in a first...
8707913 Fuel management system for variable ethanol octane enhancement of gasoline engines  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
8707789 Pressure measuring syringe  
A syringe having an internal pressure gauge comprises a syringe barrel; a piston within the barrel; a spring coupled to the piston at a first position of the spring, the spring having a second...
US20140114193 ULTRASOUND SCANNING SYSTEM  
A force-controlled ultrasound imaging device uses a linear drive system to maintain a suitable contact force with a subject. A combination of hardware and software limits on travel for the linear...
US20140113871 Modification of Peptides via SNAr Reactions of Thiols with Fluorinated Aromatics  
Disclosed are compounds and methods relating to a chemical transformation for the conjugation of unprotected peptide biomolecules via a SNAr process between highly fluorinated aryl moieties and...
US20140113019 SYSTEM FOR PASSIVE ALIGNMENT OF SURFACES  
Passive stamp alignment system. The system includes a stamp supported by a stamp holder resting on three balls affixed to a top platform. A bottom platform supports a substrate to be aligned with...
US20140109895 METALLIC COMPOSITE PHASE-CHANGE MATERIALS AND METHODS OF USING THE SAME  
Metallic composite phase-change materials and methods of using are disclosed. In some embodiments, a thermal energy storage module is provide that included one or more phase change alloys having a...
RE44856 Tactile sensor using elastomeric imaging  
A tactile sensor includes a photosensing structure, a volume of elastomer capable of transmitting an image, and a reflective skin covering the volume of elastomer. The reflective skin is...
8705604 Method and apparatus for complex in-phase/quadrature polyphase nonlinear equalization  
Complex polyphase nonlinear equalizer (cpNLEQs) mitigate nonlinear distortions generated by complex in-phase/quadrature (I/Q) time-interleaved analog-to-digital converters (TIADCs). Example cpNLEQs...
8704314 Mechanical memory transistor  
A mechanical memory transistor includes a substrate having formed thereon a source region and a drain region. An oxide is formed upon a portion of the source region and upon a portion of the drain...
8704198 Efficient high-harmonic-generation-based EUV source driven by short wavelength light  
Extreme ultraviolet radiation is generated based on high-order harmonic generation. First, a driver pulse is generated from a drive laser. Second, the infrared driver pulse is passed through a...
8703811 Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase  
Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured...
8703623 Fabrication technique for gallium nitride substrates  
A semiconductor arrangement is provided that includes one or more substrate structures. One or more nitride-based material structures are used in fabricating nitride-based devices. One or more...
8701927 Nanoparticle thin-film coatings for enhancement of boiling heat transfer  
A superhydrophilic thin film is formed on a metal surface of a boiler vessel to alter the wettability and roughness of the surface, which, in turn, changes the boiling behavior at the surface. The...
US20140108185 Methods and Apparatus for Knowledge Processing System  
In exemplary implementations of this invention, a knowledge processing system performs decentralized knowledge acquisition from human experts. The system may store the acquired knowledge in a...
US20140107839 HIGH EFFICIENCY, SMOOTH ROBOT DESIGN  
An underwater robot includes a body, a propeller connected to an end of the body, a controller, and first and second actuation units that output jets of fluid. The propeller propels the robot, and...
US20140107666 ROBOTIC APPARATUS  
A robotic apparatus has eight actuators (M0-M7) and a linkage (LINK 0-LINK 5) that actuates an end effector. Three serial macro freedoms have large ranges of motion and inertias. Four serial micro...
US20140107326 METHODS INVOLVING GRAPHENE AND FUNCTIONALIZED GRAPHENE  
Embodiments relating to the synthesis and processing of graphene molecules are provided. In some cases, methods for the electrochemical expansion and/or functionalization of graphene molecules are...
US20140105960 HYDROGELS FOR TISSUE REGENERATION  
Provided herein are hydrogels and hydrogel-forming compositions that are useful for, among others, tissue regeneration in vivo. Methods for generating such hydrogels, for example, from such...
US20140103224 HIGHLY COMPACT MULTI-OPTICAL-JUNCTION OPTICAL FLOWCELL AND FLEXIBLY DEPLOYABLE OPTICAL SENSING ASSEMBLIES AND SYSTEMS FOR IN-SITU REAL-TIME SPECTROSCOPIC MEASUREMENTS  
A highly compact multi-optical-junction optical flowcell includes a housing having an internal channel, to which a plurality of source optical signal modules can be coupled, e.g., in a peripheral...
US20140102539 FUNCTIONALIZED NANOSTRUCTURES AND RELATED DEVICES  
Embodiments described herein provide functionalized carbon nanostructures for use in various devices, including photovoltaic devices (e.g., solar cells). In some embodiments, carbon nanostructures...
US20140101986 Method for Preparing a Slurry of Pulverized Solid Material in Liquid or Supercritical Carbon Dioxide  
Method for making a slurry of a pulverized solid in liquid or supercritical carbon dioxide. The method includes making a water-pulverized solid slurry at ambient pressure and pressurizing the...
8700166 Coding for visual prostheses  
A visual prostheses codes visual signals into electrical stimulation patterns for the creation of artificial vision. In some examples, coding of the information uses image compression techniques,...
8700144 Electrode stimulator with energy recycling and current regulation  
A system and method for stimulating an electrode is provided. The stimulator includes a sensor circuit configured to couple to the at least one electrode of a medical device to measure a power...
8699248 Power converter with capacitive energy transfer and fast dynamic response  
A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or...
8698496 Method for two-dimensional correlation magnetic resonance spectroscopy  
Methods for low-power in vivo localized multi-dimensional correlated magnetic resonance spectroscopy (“MRS”) are provided. Low-power adiabaticity is achieved, generally, using gra...
8698338 Offshore energy harvesting, storage, and power generation system  
A system for harvesting, storing, and generating energy, that includes floating structure supporting machinery to extract energy from wind, waves, surface generators, or currents. At least one...
8697359 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
US20140099729 Methods and Apparatus for Artificial Olfaction  
In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this...
US20140099549 High-capacity positive electrode active material  
This disclosure provides a positive electrode active lithium-excess metal oxide with composition LixMyO2 (0.6≦y≦0.85 and 0≦x+y≦2) for a lithium secondary battery with a high reversible capacit...
US20140099522 Low-Temperature Liquid Metal Batteries for Grid-Scaled Storage  
An electrochemical cell and its method of operation includes an electrolyte having a binary salt system of an alkali hydroxide and a second alkali salt. The anode, cathode, and electrolyte may be...
US20140099289 Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair  
Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding...
8693837 High resolution near field scanning optical microscopy  
An optical fiber including a surface including a non-covalent multilayer including a light-absorbing material can be used to develop fluorescence microscopy with a lateral resolution of about 5 nm...
8692747 LED array with photodetector  
Embodiments of the present invention provide for an array, and corresponding method of forming an array, that includes a plurality of light emitting devices. The light emitting devices are disposed...
8692575 Asynchronous logic automata  
A family of self-timed, charge-conserving asynchronous logic elements that interact with their nearest neighbors permits design and implementation of circuits that are asynchronous at the bit...
8692176 Focal plane array processing method and apparatus  
A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer...
8691464 Three dimensional single-chamber fuel cells  
The present invention relates to single chamber fuel cells and systems and methods associated with the same. Architectures and materials that allow for high performance, enhanced fuel utilization,...
8691203 Method comprising contacting tissue with a cross-linkable polyester prepolymer  
The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a...
8691151 Opto-fluidic architecture for particle manipulation and sorting  
This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to...
8689726 Automated layer by layer spray technology  
The present invention comprises an automated apparatus capable of spray depositing polyelectrolytes via the LbL mechanism with minimal or no human interaction. In certain embodiments, the apparatus...
US20140095003 Electric Vehicle and Method of Battery Set-Point Control  
A method includes utilizing navigation data from a navigation system to segment a route to be travelled by a travelling vehicle into segments each having a road grade different than neighboring...
US20140094399 BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF  
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially ...
US20140094372 COMPACTLY-INTEGRATED OPTICAL DETECTORS AND ASSOCIATED SYSTEMS AND METHODS  
Compactly-integrated electronic structures and associated systems and methods are provided. Certain embodiments relate to the ability to integrate nanowire-based detectors with optical components.
US20140093911 METHOD AND APPARATUS FOR IMAGE-BASED PREDICTION AND SORTING OF HIGH-PERFORMING CLONES  
A method of predictive identification and separation of high-performing cells from a mixed population of cells includes distributing cells belonging to the mixed population to a plurality of open...
US20140093575 STABLE LAYER-BY-LAYER COATED PARTICLES  
Systems and methods for coating a particle core with a layer-by-layer film are disclosed.
US20140091409 APPLICATIONS OF CONTACT-TRANSFER PRINTED MEMBRANES  
The disclosed embodiments provide sensitive pixel arrays formed using solvent-assisted or unassisted release processes. Exemplary devices include detectors arrays, tunable optical instruments,...
US20140090686 METHODS AND APPARATUS FOR CONCENTRATING PHOTOVOLTAICS  
Provided in one embodiment is an article, comprising: a substrate comprising silicon; and a plurality of solar cells disposed over the substrate, wherein at least one of the plurality of the solar...