Patents and Patent Applications from Massachusetts Institute of Technology MIT


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9718709 Multi-stage membrane distillation process  
Portions of a feed liquid are passed through respective condensers and liquid-liquid heat exchangers. The feed liquid is then heated and injected into a first feed-liquid containment chamber,...
9717749 Production of stable non-polyadenylated RNAs  
The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3′ terminal stabilizing triple...
US20170214861 RAPID AND PRECISE OPTICALLY MULTIPLEXED IMAGING  
Described herein are devices and methods for uniquely encoding one or more channels of an optically multiplexed imaging system rapidly and precisely to improve the system's efficiency and...
US20170214472 APPARATUS AND METHODS FOR RECONFIGURABLE OPTICAL RECEIVERS  
An optical receiver includes a cascade of optical filtering elements, each of which selects spectral components from incoming optical signals at a wavelengths aligned to filter passbands. The...
US20170212405 APPARATUS AND METHODS FOR SINGLE PHOTON SOURCES  
A photon source to deliver single photons includes a storage ring resonator to receive pump photons and generate a signal photon and an idler photon. An idler resonator is coupled to the storage...
US20170212059 Methods and apparatus for imaging of near-field objects with microwave or terahertz radiation  
An imaging system images near-field objects with focused microwave or terahertz radiation. Multiple antennas emit microwave or terahertz radiation, such that the radiation varies in frequency over...
US20170211977 DEVICES AND METHODS FOR SENSING TARGETS USING PHOTOTHERMAL SPECKLE DETECTION  
A device, and corresponding method, can include a pump light source configured to be modulated at a pump modulation and to irradiate a target specimen. The device can also include a probe light...
US20170211142 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
US20170211061 NOVEL RECOMBINASES AND TARGET SEQUENCES  
The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine...
US20170209846 METHODS AND SYSTEMS FOR CARRYING OUT A PH-INFLUENCED CHEMICAL AND/OR BIOLOGICAL REACTION  
The present invention generally relates to methods and systems for carrying out a pH-influenced chemical and/or biological reaction. In some embodiments, the pH-influenced reaction involves the...
9714941 Bio-sensing nanodevice  
The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding...
9714379 Highly luminescent semiconductor nanocrystals  
A method of making a semiconductor nanocrystal can include contacting an M-containing compound with an X donor having the formula X(Y(R)3)3, where X is a group V element and Y is a group IV element.
9714265 Mutagenic nucleoside analogs and uses thereof  
The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs are expected to show multiple tautomerism and may increase the mutation of an RNA and/or DNA (be...
9713873 Continuum style manipulator actuated with phase change media  
A continuum style manipulator is actuated by jammable media within an envelope of a module, which is also actuated by a tensile element, such as a cable and spooler motor. Multiple modules may be...
9713808 Highly Z-selective olefin metathesis  
The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.
US20170208695 Sleeved Coaxial Printed Circuit Board Vias  
A printed circuit board, and a method of fabricating the printed circuit board is disclosed. The printed circuit board includes at least one coaxial via. A hollow via is disposed in the printed...
US20170208399 NORMALIZING SIGNAL ENERGY FOR SPEECH IN FLUCTUATING NOISE  
An approach to audio processing aims to improve intelligibility by amplifying time segments of an input signal when the level of the signal falls below a long-term average level of the input...
US20170208274 METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE IMAGING  
When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital...
US20170204399 GENOMICALLY-ENCODED MEMORY IN LIVE CELLS  
Aspects of the present disclosure provide synthetic-biology platforms for in vivo genome editing, which enable the use of live cell genomes as “tape recorders” for long-term recording of event...
US20170204367 Cell Rolling Separation  
The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and...
US20170204075 AMINOALCOHOL LIPIDOIDS AND USES THEREOF  
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting...
US20170204015 ALKALI METAL ION SOURCE WITH MODERATE RATE OF ION RELEASE AND METHODS OF FORMING  
An alkali metal ion source with a moderate rate of release of the ion (e.g. potassium) is formed by a method that includes: 1) combining an particulate ore that contains at least one of an alkali...
US20170203966 DIHYDROGEN TETRAMETAPHOSPHATE, ITS DERIVATIVES, AND PREPARATION THEREOF  
Dihydrogen metaphosphate can be synthesized via protonation, and can react with a dehydrating agent to afford tetrametaphosphate anhydride. A monohydrogen tetra-metaphosphate organic ester can be...
US20170202462 SYSTEMS AND METHODS FOR SPECTROSCOPY OF BIOLOGICAL TISSUE  
The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In...
9712771 Digital readout method and apparatus  
Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. Such an array is particularly...
9712501 Packet header randomization  
A system and method for the randomization of packet headers is disclosed. A controller is used to provide random values, also referred to as nonces, that replace the source and destination...
9711594 Improving linearity in semiconductor devices  
A field effect transistor that has a source, a drain, a gate and a semiconductor region. The semiconductor region has a source access region between the gate and the source, a drain access region...
9711254 Toroidal bending magnets for hadron therapy gantries  
Toroidal superconducting magnets can be used as lightweight rotating bending magnets in hadron therapy gantries. The toroidal bending magnets are self-shielded and do not require ferromagnetic...
9710917 Methods and apparatus for refractive flow measurement  
An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video...
9709567 Compositions and methods for diagnosing and/or treating influenza infection  
The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding...
9709479 Method and apparatus for tracking cell identity  
A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads...
9709440 Methods and apparatus for spectrometry using multimode interference in a tapered spiral-shaped waveguide  
Multimode interference can be used to achieve ultra-high resolving powers (e.g., Q>105) with linewidths down to 10 pm at 1500 nm and a broad spectroscopy range (e.g., 400-2400 nm) within a...
9708965 Optimized fuel management system for direct injection ethanol enhancement of gasoline engines  
Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. It is preferred that the direct...
9708648 HiC: method of identifying interactions between genomic loci  
The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or...
9708184 Microspheres including nanoparticles  
A microparticle can include a central region and a peripheral region. The peripheral region can include a nanoparticle, such as a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor...
9707313 Biocompatible adhesive materials and methods  
Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive...
US20170200966 METAL SULFIDE ELECTRODES AND ENERGY STORAGE DEVICES THEREOF  
The present invention generally relates to energy storage devices, and to metal sulfide energy storage devices in particular. Some aspects of the invention relate to energy storage devices...
US20170200700 Interconnect Structures for Assembly of Multi-Layer Semiconductor Devices  
A multi-layer semiconductor device includes at least two semiconductor structures, each of the at least two semiconductor structures having first and second opposing surfaces and including a first...
US20170200648 METHOD OF MANUFACTURING A SUBSTRATE  
A method of manufacturing a substrate is disclosed. The method comprises: providing a first semiconductor substrate, which includes an at least partially processed CMOS device layer and a layer of...
US20170199402 METHOD FOR FORMING MAGNETO-OPTICAL FILMS FOR INTEGRATED PHOTONIC DEVICES  
Methods for forming magneto-optical films for integrated photonic devices and integrated photonic devices incorporating same are described. An optical isolator or any nonreciprocal photonic...
US20170198307 METHODS FOR TARGETED MODIFICATION OF GENOMIC DNA  
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting...
US20170198269 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
US20170198217 SYNTHESIS OF NANOCRYSTALS  
A nanocrystal composition can include a nanocrystal and an outer layer including a ligand bound to the nanocyrstal, wherein the ligand includes a norbornene group and a carboxyl group.
US20170198007 METHODS FOR IDENTIFICATION OF SITES FOR IGG CONJUGATION  
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and...
US20170197187 EMULSIONS BY CONDENSATION  
Nanoscale emulsions can be made by means of condensing a liquid vapor onto another liquid. The precise size, chemical composition, and density of emulsions may be controlled through varying the...
US20170196938 CARRIER-FREE BIOLOGICALLY-ACTIVE PROTEIN NANOSTRUCTURES  
The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other...
9705854 Cryptography and key management device and architecture  
A method for operating a secure device having a plurality of mutually exclusive circuit zones, including a first circuit zone having a first level of security and a second circuit zone having a...
9705167 Lithium ion conducting protective film and method of use  
A lithium ion conducting protective film is produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the...
9704959 Enhancement-mode transistors with increased threshold voltage  
A field effect transistor that has a source, a drain, a gate, a semiconductor region, and a dielectric region. The dielectric region is located between the semiconductor region and the gate....
9704685 Pyrolyzed porous carbon materials and ion emitters  
Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described.