Patents and Patent Applications from Massachusetts Institute of Technology MIT


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9291565 Three dimensional scanning using membrane with optical features  
Various improvements to inflatable membranes for use in three-dimensional imaging of interior spaces are disclosed. These improvements include, among other things, equipping the inflatable...
9291549 Pathogen detection biosensor  
The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne...
9290579 Covalently immobilized protein gradients in three-dimensional porous scaffolds  
The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The...
9289946 Automated three-dimensional printer part removal  
Three-dimensional printing system with automated part removal. In one embodiment, the system includes a printing surface on which a part is made and a printing device supported for controlled...
9289506 Surface binding of nanoparticle based drug delivery to tissue  
Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as...
9289133 Methods and apparatus for determining cardiac output  
The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained...
9289120 Temporal structured-illumination motion-detection system  
The present invention provides devices and methods for detecting and tracking fast-moving-object. In one application, the present invention can be employed to detect and track fast eye movements...
US20160079592 ALUMINUM BASED ELECTROACTIVE MATERIALS  
An electroactive material including an aluminum nanoparticle core and a nanoshell surrounding the aluminum nanoparticle core as well as its methods of use and manufacture are described.
US20160079060 Patterning of Nanostructures  
A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern...
US20160076978 DEPOSITION AND IMAGING OF PARTICLES ON PLANAR SUBSTRATES  
Among other aspects, the present invention provides for the deposition of biological particles, such as cells, in a liquid, in a desired two-dimensional pattern on a planar surface of a substrate...
US20160076778 LOCALIZED THERMAL MANAGEMENT SYSTEM  
Localized thermal management system. The system includes an array of emitters of beams of infrared radiation mourned for rotation within a volumetric space. A motion tracking system determines...
US20160076061 ENGINEERING MICROBES AND METABOLIC PATHWAYS FOR THE PRODUCTION OF ETHYLENE GLYCOL  
The invention relates to recombinant cells and their use in the production of ethylene glycol.
US20160075742 HUMAN ADAPTATION OF H3 INFLUENZA  
The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention...
US20160075089 Methods and apparatus for additive manufacturing along user-specified toolpaths  
One or more input/output devices accept user-inputted path instructions that specify a set of multiple deposition paths for an extruder to travel. An actuator actuates motion of the extruder along...
US20160074812 Energy-Efficient Conductive-Gap Membrane Distillation  
Apparatus for energy-efficient conductive-gap membrane distillation includes a feed-liquid source and a distillation module. The distillation module includes a feed-liquid chamber in fluid...
US20160074538 NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING APPLICATIONS  
A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized...
9287713 Topology identification in distribution network with limited measurements  
A statistical technique is used to estimate the status of switching devices (such as circuit breakers, isolator switches and fuses) in distribution networks, using scares (i.e., limited or...
9286312 Data coreset compression  
An approach to compression of a large (n point or samples) data set has a combination of one or more desirable technical properties: for a desired level of accuracy (ε), the number of compressed...
9285290 Leak detection apparatus  
Leak detection apparatus for deployment in a pipe. The apparatus includes a carrier disposed for motion along the pipe and a detector connected to move with the carrier in an axial direction. The...
9284825 Gas-lift safety valve actuated by a sensor  
A valve actuator, valve, and method of actuation of a valve are disclosed. The valve actuator includes a shape memory alloy element attachable to a valve body, capable of use with a valve to cause...
9284570 Microbial production of natural sweeteners, diterpenoid steviol glycosides  
The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides.
9284562 Biological circuit chemotactic converters  
Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and...
9284541 Methods and compositions for protein labeling using lipoic acid ligases  
The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants...
9283242 Uses of dihydro bases  
The present invention provides pharmaceutical compositions comprising a dihydro base described herein (e.g., compound DHdC). The dihydro base may show multiple tautomerism and may increase...
9283184 Methods and compositions for localized agent delivery  
The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability....
US20160071278 Method for Mapping an Environment  
A method for mapping an environment comprises moving a sensor along a path from a start location (P0) through the environment, the sensor generating a sequence of images, each image associated...
US20160070254 Methods and Apparatus for Digital Material Skins  
A digital material skin is made of a set of discrete units with a finite set of parts and joints. The discrete units are assembled into a layer according to a regular geometry, with each of the...
US20160070161 Illuminated 3D Model  
An illuminated three-dimensional model is fabricated by importing or generating a digital dataset representing the surface of a three-dimensional source surface; producing a three-dimensional...
US20160070125 SYSTEMS, METHODS, AND APPARATUS FOR SENSITIVE THERMAL IMAGING  
The high-pixel-count uncooled thermal imaging arrays disclosed herein have liquid crystal (LC) microcavity transducers separate from the read-out integrated circuit (ROIC). The transducer converts...
US20160068899 METHODS FOR QUANTITATING DNA USING DIGITAL MULTIPLE DISPLACMENT AMPLIFICATION  
The present invention provides improved methods for detecting contamination in WGA reagents as well as improved methods for quantitating nucleic acids, such as DNA. The present invention relates...
US20160068822 RECOMBINANT VIRUS AND PREPARATIONS THEREOF  
The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making...
US20160067346 BRUSH-POLY (GLYCOAMIDOAMINE)-LIPIDS AND USES THEREOF  
The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include...
US20160067250 Methods of Reducing Kinase Inhibitor Resistance  
Methods, compounds and kits relating to treating cancer, reducing kinase inhibitor or resistance, and reducing or preventing diminished ectodomain shedding are described.
US20160067190 INJECTABLE NANO-NETWORK GELS FOR DIABETES TREATMENT  
A system for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged...
US20160066775 METHODS, SYSTEMS, AND APPARATUS FOR IMAGING SPECTROSCOPY  
Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging...
9278998 Compositions and methods for diagnosing and/or treating influenza infection  
The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding...
US20160064788 AIR SECONDARY BATTERY  
An air secondary battery has a positive electrode to which an oxygen-containing gas is supplied, a negative electrode containing a metal active material, and an electrolytic solution through which...
US20160064787 AIR SECONDARY BATTERY  
An air secondary battery has a cathode to which an oxygen-containing gas is supplied, an anode containing an active metal material, and an electrolyte interposed between the cathode and the anode....
US20160064734 SODIUM TRANSITION METAL OXIDE ELECTROACTIVE COMPOUNDS  
Embodiments related to electroactive compounds, their methods of manufacture, and use are described. In one embodiment, an electroactive compound may include Na(FeaX1-a)O2. X includes at least one...
US20160064539 SEMICONDUCTOR STRUCTURE AND RECESS FORMATION ETCH TECHNIQUE  
A semiconductor structure has a first layer that includes a first semiconductor material and a second layer that includes a second semiconductor material. The first semiconductor material is...
US20160064156 High-Performance Supercapacitors Based on Metal Nanowire Yarns  
An energy-storage device is formed from a first and a second yarn, each yarn including a plurality of nanowires including aluminum and/or a transition metal. An anode pad is in contact with the...
US20160060519 HIGHLY LUMINESCENT COLOR-SELECTIVE NANOCRYSTALLINE MATERIALS  
A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.
US20160060166 In-Fiber Particle Generation  
A fiber is provided, including a cladding material that is disposed along a longitudinal-axis fiber length. A plurality of spherical particles are disposed as a sequence along a longitudinal line...
US20160058851 USE OF ANTAGONISTS OF GHRELIN OR GHRELIN RECEPTOR TO PREVENT OR TREAT STRESS-SENSITIVE PSYCHIATRIC ILLNESS  
The invention relates to methods of protecting against chronic stress in a subject and treating stress sensitive disorders in a subject by antagonizing ghrelin or ghrelin receptor.
9274108 Self-assembly of macromolecules on multilayered polymer surfaces  
The invention is directed toward systems and methods for the formation of two dimensional monolayer structures of ordered biomacromolecules, such as viruses, atop cohesive polyelectrolyte...
9274047 Methods and apparatus for imaging of occluded objects  
An active imaging system, which includes a light source and light sensor, generates structured illumination. The light sensor captures transient light response data regarding reflections of light...
9273883 Concentrated solar power system  
Systems and methods for concentrating and storing solar energy are provided. A solar energy receiver for use with the systems and methods may include a container for holding a solar absorption...
9273307 Global transcription machinery engineering  
The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.
9272022 Compositions and methods for treating cancer and modulating stress granule formation  
The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase...
US20160056309 METHOD AND OPTOELECTRONIC STRUCTURE PROVIDING POLYSILICON PHOTONIC DEVICES WITH DIFFERENT OPTICAL PROPERTIES IN DIFFERENT REGIONS  
Method and structural embodiments are described which provide an integrated structure using polysilicon material having different optical properties in different regions of the structure.