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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20150035880 Methods and Apparatus for Visual Display  
In exemplary implementations of this invention, light from a backlight is transmitted through two stacked LCDs and then through a diffuser. The front side of the diffuser displays a time-varying...
8949024 Vehicle localization using surface penetrating radar  
Described are a method and a system for localization of a vehicle. The method includes the acquisition of SPR images of a subsurface region along a vehicle track. Acquired SPR images are compared...
8947516 High-resolution 3D imaging of single semiconductor nanocrystals  
A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying...
8945839 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8945393 Magnetic colloid petroleum oil spill clean-up of ocean surface, depth, and shore regions  
Method for oil removal. The method includes adding a magnetizable material, with or without appropriately selected surfactants, of order micron (having no net magnetization) or nanometer size to...
US20150032190 METHODS AND APPARATUS FOR OMNIDIRECTIONAL TISSUE ILLUMINATION  
Embodiments of the present invention include a fiber-optic tissue illuminator suitable for illuminating large areas of central and peripheral neural tissue, e.g., in a primate brain. Certain...
US20150031138 EMISSIVE COMPOSITIONS WITH INTERNAL STANDARD AND RELATED TECHNIQUES  
The present invention provides materials, devices, and methods related to determination of an analyte. In some embodiments, an analyte may be determined by monitoring, for example, a change in an...
US20150031134 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20150030661 Multilayer Films and Uses Thereof  
The invention provides, inter alia, multilayer films of alternating layers of a glycosylated polymer (e.g. a mucin) and a lectin, as well as methods of making and using these films. The films can...
US20150030659 Methods And Compositions For The Treatment Of Open And Closed Wound Spinal Cord Injuries  
Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and...
US20150030641 GLUCOSE-RESPONSIVE MICROGELS FOR CLOSED LOOP INSULIN DELIVERY  
Injectable insulin loaded microgels that are capable of modifying the amount of insulin released based on the patient's tissue glucose levels, methods for making and using these compositions have...
US20150029581 THULIUM LASER  
Stimulating emission via thulium's lasing transition from the 3H4 manifold to the 3H6 manifold yields light at wavelength of about 820 nm. Unfortunately, excited thulium ions also transition from...
US20150029505 Spark-Induced Breakdown Spectroscopy Electrode Assembly  
A spark-induced breakdown spectroscopy apparatus can have a housing with an inlet and an outlet that define an analyte flow path. A laser can define a laser pathway generally transverse to an...
US20150029058 ACCURATE TIMING DISTRIBUTION BY HIGH-FREQUENCY RADIO  
A method of obtaining an absolute time reference for a high-frequency (HF) sounding signal includes transmitting a reference signal at a first location and transmitting a sounding signal in close...
US20150028346 ALUMINUM NITRIDE BASED SEMICONDUCTOR DEVICES  
Semiconductor structures and techniques are described which enable forming aluminum nitride (AIN) based devices by confining carriers in a region of AIN by exploiting the polar nature of AIN...
US20150027529 ELECTRODES FORMED BY OXIDATIVE CHEMICAL VAPOR DEPOSITION AND RELATED METHODS AND DEVICES  
The present invention generally relates to electrodes formed by oxidative chemical vapor deposition and related methods and devices.
8941299 Light emitting device including semiconductor nanocrystals  
A light emitting device includes an electroluminescent material and semiconductor nanocrystals. The semiconductor nanocrystals accept energy from the electroluminescent material and emit light.
8941285 Nanoscale thermoelectric wave generators  
In one aspect, the present invention provides nanosized systems for generating electrical energy based on the use of a chemically reactive composition to generate a thermoelectric wave. For...
8940732 Diagnosis of autism spectrum disorders and its treatment with an antagonist or inhibitor of the 5-HT2c receptor signaling pathway  
The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and...
8940500 Methods for identifying stem cells by detecting fluorescence of cells and syncytia  
Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting...
8940361 Self-lubricating surfaces for food packaging and food processing equipment  
In certain embodiments, the invention relates to an article having a liquid-impregnated surface. The surface includes a matrix of solid features (e.g., non-toxic and/or edible features) spaced...
8939774 Methods and apparatus for three-dimensional microfabricated arrays  
In exemplary implementations of this invention, electrical connections are fabricated between two orthogonal surfaces by electroplating. The two surfaces are separated (except for the electrical...
US20150025505 Bi-Directional Motion of a Lorentz-Force Actuated Needle-Free Injector (NFI)  
The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some...
US20150025005 SELF-REGULATED PEPTIDE HYDROGEL FOR INSULIN DELIVERY  
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose...
US20150023875 System for Targeted Delivery of Therapeutic Agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
US20150023857 PIEZOELECTRIC AND ELECTRORESTRICTOR MATERIALS  
One embodiment provides a method, comprising: calculating, using at least one computer, a distance to a hull for an alloy XxY1-x in the range 0.01≦x≦0.99, where X and Y are perovskite materials;...
US20150023789 Wind Turbine Power Augmentation  
Wind power generator. The generator includes a wind turbine rotating in an aerodynamically contoured duct and capable of generating increased power by increasing the wind flow at the turbine. A...
US20150023063 Resonant Power Converters Using Impedance Control Networks And Related Techniques  
An impedance control resonant power converter (converter) operated at a fixed switching frequency includes an impedance control network (ICN) coupled between two or more inverters operated at a...
US20150021480 VISIBLE-INFRARED PLANE GRATING IMAGING SPECTROMETER  
An imaging spectrometer, covering the visible through infrared wavelengths, which disperses the light by a plane diffraction grating behind a wedged optical element. This design uses an achromatic...
8937373 Highly luminescent II-V semiconductor nanocrystals  
A population of semiconductor nanocrystals can include cores including a II-V semiconductor material, e.g., Cd3As2. The population can be monodisperse and can have a quantum yield of 20% or...
8937001 Patterning of nanostructures  
A technique for forming nanostructures including a definition of a charge pattern on a substrate and introduction of charged molecular scale sized building blocks (MSSBBs) to a region proximate...
8935960 Method and kit for stand-off detection of explosives  
A kit for detecting the presence of an explosive includes a pulsed focused energy source located at a target distance away from a substrate, the energy having a magnitude sufficient to release the...
US20150020223 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20150018665 MOLECULAR AND CELLULAR IMAGING USING ENGINEERED HEMODYNAMIC RESPONSES  
According to some aspects, the invention relates to methods and compositions for evaluation of hemodynamic responses (e.g., using molecular imaging) with high sensitivity.
US20150018220 Persistent-Mode MRI Magnet Fabricated From Reacted, Monofilamentary MgB2 Wires And Joints  
A superconducting magnet and method for making a superconducting magnet, are presented. The superconducting magnet is made by forming a coil from windings of a first wire comprising a reacted MgB2...
US20150017120 SYNERGISTIC TUMOR TREATMENT WITH EXTENDED-PK IL-2 AND ADOPTIVE CELL THERAPY  
The present invention provides a method of enhancing adoptive cell therapy (ACT) by administering an extended-pharmacokinetic (PK) interleukin (IL)-2 to a cancer subject receiving ACT, optionally...
US20150017022 SURFACE ADSORPTION VACUUM PUMPS AND METHODS FOR PRODUCING ADSORBATE-FREE SURFACES  
Methods for pumping a chamber to generate substantially adsorbate-free surfaces are described. Pumping systems for achieving a vacuum based on surface adsorption are also described.
US20150016690 METHODS AND APPARATUS FOR REFRACTIVE FLOW MEASUREMENT  
An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video...
US20150015960 Gradient SiNO Anti-Reflective Layers in Solar Selective Coatings  
A solar selective coating includes a substrate, a cermet layer having nanoparticles therein deposited on the substrate, and an anti-reflection layer deposited on the cermet layer. The cermet layer...
US20150014045 Sleeved Coaxial Printed Circuit Board Vias  
A printed circuit board, and a method of fabricating the printed circuit board is disclosed. The printed circuit board includes at least one coaxial via. A hollow via is disposed in the printed...
8933832 Digital readout method and apparatus  
Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. Such an array is particularly...
8933496 Electronically controlled squishable composite switch  
A method and apparatus for making analog and digital electronics which includes a composite including a squishable material doped with conductive particles. A microelectromechanical systems (MEMS)...
8933071 Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders  
Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for...
8933044 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
8932974 Mesostructured zeolitic materials, and methods of making and using the same  
One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for...
8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8932595 Nicotine immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
US20150011830 TIP ACTUATED DISPOSABLE ENDOSCOPE  
The present invention relates to an endoscope having a motorized assembly to control the distal end of an endoscope. Preferred embodiments can include disposable and reusable components. The...
US20150011404 Microfluidic Bubble Logic Devices  
Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices,...
US20150009706 OPTICAL STRUCTURES INCLUDING NANOCRYSTALS  
An optical structure can include a nanocrystal on a surface of an optical waveguide in a manner to couple the nanocrystal to the optical field of light propagating through the optical waveguide to...