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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20140321600 METHODS AND APPARATUS FOR IN-PIXEL FILTERING IN FOCAL PLANE ARRAYS  
Digital focal plane arrays (DFPAs) with multiple counters per unit cell can be used to convert analog signals to digital data and to filter the digital data. Exemplary DFPAs include two-dimensional...
US20140320125 NON-INTRUSIVE MONITORING  
Methods and apparatus for non-intrusive monitoring by sensing physical parameters such as electric and/or magnetic fields. Such apparatus and techniques may find application in a variety of fields,...
US20140318972 DESALINATION AND PURIFICATION SYSTEM  
A liquid electrolyte can be desalinated and purified using a system that includes a first electrode and a configuration selected from (a) a second electrode and at least one distinct ion-selective...
8874404 Simulating earpiece fit based upon dynamic data  
The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements...
8871456 Probe incorporation mediated by enzymes  
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and...
8871445 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8871074 Method and apparatus for permeating flow desalination  
A water desalination system and method in accordance with the principles of the present invention employs capacitive deionization to remove ions from source water to produce deionzed and waste...
8870967 Artificial joints using agonist-antagonist actuators  
Artificial limbs and joints that behave like biological limbs and joints employ a synthetic actuator which consumes negligible power when exerting zero force, consumes negligible power when...
8869599 Leak detection system based on force transduction  
Leak detection system. A rigid body is resiliently supported within an outer cage. Structure is provided for detecting displacement of the rigid body with respect to the outer cage, the...
US20140316088 METATHESIS CATALYSTS AND METHODS THEREOF  
The present invention provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I or II. In some...
US20140315753 ENGINEERING A HETEROGENEOUS TISSUE FROM PLURIPOTENT STEM CELLS  
Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
US20140315310 RECOMBINASE-BASED LOGIC AND MEMORY SYSTEMS  
The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells.
US20140314982 GRAFTED POLYMER SURFACES FOR DROPWISE CONDENSATION, AND ASSOCIATED METHODS OF USE AND MANUFACTURE  
Presented herein are articles and methods featuring substrates with thin, uniform polymeric films grafted (e.g., covalently bonded) thereupon. The resulting coating provides significant reductions...
US20140314976 Methods and Apparatus for Shape Control  
In exemplary implementations of this invention, a shape controller controls the shape of a bladder as the bladder inflates. The shape controller includes a first set of regions and a second set of...
US20140314947 ARTICLES AND METHODS FOR ENHANCED BOILING HEAT TRANSFER  
The present disclosure provides, among other things, scale-coated surfaces, vessels with controlled deposits of scale, and associated methods for enhanced boiling heat transfer. It is presently...
US20140314865 Vaccine Nanotechnology  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune...
US20140314864 System for Targeted Delivery of Therapeutic Agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
US20140314826 NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT  
The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer...
US20140313781 Stacked Switched Capacitor Energy Buffer Circuit Architecture  
Described herein is a stacked switched capacitor (SSC) energy buffer circuit architecture and related design and control techniques.
US20140311967 POROUS MATERIALS AND METHODS INCLUDING NANOPOROUS MATERIALS FOR WATER FILTRATION  
Embodiments described herein relate to porous materials that may be employed in various filtration, purification, and/or separation applications. In some cases, the porous materials may be thin,...
US20140311507 Porous Catalytic Matrices for Elimination of Toxicants Found in Tobacco Combustion Products  
Described herein are compositions and methods for capturing carbonylic or phenolic toxicants, or converting these toxicants into less volatile compounds. The toxicants, which may be a component of...
US20140311207 THERMO-MECHANICAL PROCESS TO ENHANCE THE QUALITY OF GRAIN BOUNDARY NETWORKS IN METAL ALLOYS  
Methods to enhance the quality of grain boundary networks are described. The process can result in the production of a metal including a relatively large fraction of special grain boundaries (e.g.,...
8868163 Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal  
A method and apparatus for predicting patient outcome from a physiological segmentable signal of a patient. In one embodiment, the method comprises the steps of obtaining the physiological...
8867046 Method and apparatus for measuring a position of a particle in a flow  
A method and an apparatus of measuring a position of a particle in a flow are disclosed. An embodiment of the method comprises temporally modulating and spatially pattering an illumination beam...
8866663 Methods and apparatus for sensing organic tissue  
In exemplary implementations of this invention, a radio signal is transmitted between a transmitter and a receiver. Either the transmitter, or receiver, or both, have a directional antenna. When...
8866478 Method and processor and magnetic resonance apparatus for designing RF pulses to mitigate off-resonance effects  
In a magnetic resonance apparatus and operating method therefor, and in a processor that is programmed to design RF pulses for operating such a magnetic resonance apparatus, the RF pulses are...
8865995 Methods for high figure-of-merit in nanostructured thermoelectric materials  
Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help...
8865788 Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices  
A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred...
8865630 High-throughput platform for in-vivo sub-cellular screens on vertebrate larvae  
High throughput system for in vivo screens on vertebrate larvae. The system includes a source of vertebrate larvae in a liquid medium and loading tube means for aspirating a larva. A detector...
8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8865297 Heterogeneous surfaces  
Condensation can be an important process in both emerging and traditional power generation and water desalination technologies. Superhydrophobic nanostructures can promise enhanced condensation...
8865109 Systems and methods related to the formation of carbon-based nanostructures  
Systems and methods for the formation of carbon-based nanostructures are generally described. In some embodiments, the nanostructures may be formed on a nanopositor. The nanopositor can comprise,...
8864846 Model-based neuromechanical controller for a robotic leg  
A model-based neuromechanical controller for a robotic limb having at least one joint includes a finite state machine configured to receive feedback data relating to the state of the robotic limb...
8863556 Optoelectronic fiber codrawn from conducting, semiconducting, and insulating materials  
The invention provides techniques for drawing fibers that include conducting, semiconducting, and insulating materials in intimate contact and prescribed geometries. The resulting fiber exhibits...
US20140309388 METATHESIS CATALYSTS AND METHODS THEREOF  
The present application provides, among other things, novel compounds for metathesis reactions, and methods for preparing and using provided compounds. In some embodiments, the present invention...
US20140308711 ENZYMATIC PHOSPHOROTHIOATION OF DNA OR RNA  
This invention relates to methods, compositions, and kits for enzymatic phosphorothioation of the sugar-phosphate backbone of nucleic acids. The invention allows for phosphorothioation of...
US20140308336 LOCAL DRUG DELIVERY DEVICES AND METHODS FOR TREATING CANCER  
Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting...
US20140308234 DRUG DELIVERY POLYMER AND USES THEREOF  
Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods...
US20140307931 FULLY AUTOMATED SYSTEM AND METHOD FOR IMAGE SEGMENTATION AND QUALITY CONTROL OF PROTEIN MICROARRAYS  
A system for providing fully automated image segmentation and quality control of a protein array with no human interaction is presented. The system includes a memory and a processor configured by...
US20140306740 TIME-INTERLEAVED MULTI-MODULUS FREQUENCY DIVIDER  
Described are a multi-modulus frequency divider and event counter that are based on time-interleaved signals generated from a received signal. For the frequency divider, each time-interleaved clock...
8862520 Methods, systems and media utilizing ranking techniques in machine learning  
Methods, systems and media are taught utilizing ranking techniques in machine learning to learn a ranking function. Specifically, ranking algorithms are applied to learn a ranking function that...
8860260 High-scan rate positioner for scanned probe microscopy  
A system contains a first actuator half containing a first pair of actuator coils and a second pair of actuator coils located above the first pair of actuator coils, wherein the first pair of...
8859990 Highly compact multi-optical-junction optical flowcell and flexibly deployable optical sensing assemblies and systems for in-situ real-time spectroscopic measurements  
A highly compact multi-optical-junction optical flowcell includes a housing having an internal channel, to which a plurality of source optical signal modules can be coupled, e.g., in a peripheral...
8859456 Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications  
One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional...
8858966 Methods and compositions for the treatment of open and closed wound spinal cord injuries  
Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and...
8857410 Fuel management system for variable ethanol octane enhancement of gasoline engines  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
US20140303730 SYSTEMS AND METHODS FOR ENDOSCOPIC VERTEBRAL FUSION  
The present invention relates to systems and methods for treatment of the spine. Preferred embodiments utilize a tool system to remove tissue from the intervertebral space, a system for delivery of...
US20140303014 MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS  
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography...
US20140302370 METAL SULFIDE ELECTRODES AND ENERGY STORAGE DEVICES THEREOF  
The present invention generally relates to energy storage devices, and to metal sulfide energy storage devices in particular. Some aspects of the invention relate to energy storage devices...
US20140302261 Flexural Digital Material Construction and Transduction  
Flexural digital materials are discrete parts that can be assembled into a lattice structure to produce an actuatable structure capable of coordinated reversible spatially-distributed deformation....