Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20160030598 Reaction-Based Fluorescent Probes for Detecting Zinc  
Disclosed are compounds and methods useful in the detection of e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+....
US20160030360 MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS  
Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The...
US20160030359 Multi-Layer Hydrogel Capsules for Encapsulation of Cells and Cell Aggregates  
Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the...
9253608 Wireless reliability architecture and methods using network coding  
Network-coding-enabled reliability architectures and techniques are provided that are capable of enhancing data transfer reliability and efficiency in next generation wireless networks. In some...
9252712 Hardware-efficient signal-component separator for outphasing power amplifiers  
Described herein is a fixed-point piece-wise linear (FP PWL) approximation technique for computations of nonlinear functions. The technique results in circuit designs having relatively few and...
9252658 Level-crossing based circuit and method with offset voltage cancellation  
A level-crossing based circuit with offset voltage cancellation includes a first level-crossing detector section having a first output capacitor, wherein the first level-crossing section is...
9251565 Hyper-resolution imaging  
Methods and a computer program product for deriving a super-resolution image of a physical object by fusing cameras of multiple resolutions (spatial, temporal, or spectral), the super-resolution...
9251527 System and method for providing personalized recommendations  
A system and method for providing a personalized recommendation from a series of partial preferences is presented. A preference distribution of a population including a plurality of weighted...
9251424 Assisted video surveillance of persons-of-interest  
Methods, systems and media are described for computer-assisted video surveillance. Methods may support detection of moving persons in video frames, extraction of features of the detected moving...
9249387 Modular platform for multi-tissue integrated cell culture  
The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of...
9248421 Parallel integrated bioreactor device and method  
In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another...
US20160028403 SUPERCONDUCTING THREE-TERMINAL DEVICE AND LOGIC GATES  
A three-terminal device that exhibits transistor-like functionality at cryogenic temperatures may be formed from a single layer of superconducting material. A main current-carrying channel of the...
US20160028402 SUPERCONDUCTING THREE-TERMINAL DEVICE AND LOGIC GATES  
A three-terminal device that exhibits transistor-like functionality at cryogenic temperatures may be formed from a single layer of superconducting material. A main current-carrying channel of the...
US20160024687 Confined Lateral Growth of Crystalline Germanium Material  
There is provided a substrate with a lower growth confinement layer disposed thereon. An upper growth confinement layer is disposed above and vertically separated from the lower growth confinement...
US20160024577 Methods for Identifying Stem Cells Based on Nuclear Morphotypes  
Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions,...
US20160024572 Massively Multiplexed RNA Sequencing  
A method for parallel sequencing target RNA from samples from multiple sources while maintaining source identification is provided. The method includes providing samples of RNA comprising target...
US20160023904 STRAIN ENGINEERED MICROSTRUCTURES  
The present invention generally relates to articles comprising microstructures and methods for forming microstructures. The microstructures may be mechanically coupled to impart complex three...
US20160023403 SYSTEMS AND METHODS OF MACHINE VISION ASSISTED ADDITIVE FABRICATION  
The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration...
US20160022839 THERAPEUTIC RETROVIRAL VECTORS FOR GENE THERAPY  
Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
US20160022835 Targeted Polymeric Inflammation-Resolving Nanoparticles  
Sub-100 micron multimodal nanoparticles have four main components: 1) a target element (peptides, lipids, antibodies, small molecules, etc.) that can selectively bind to cells, tissues, or organs...
US20160022821 BIODEGRADABLE POLY (BETA-AMINO ESTERS) AND USES THEREOF  
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially...
US20160022794 SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA  
The present invention provides novel enterobactin-carrier protein conjugates and salmochelin-carrier protein conjugates, such as compounds of Formula (I), and salts thereof. The present invention...
9246310 Wavelength beam combining of quantum cascade laser arrays  
A laser source based on a quantum cascade laser array (QCL), wherein the outputs of at least two elements in the array are collimated and overlapped in the far field using an external diffraction...
9244080 Method for diagnosing allergic reactions  
The invention provides a method for multiple cytokine detection from single cells for the purpose of generating immunological profiles of diseases.
9244071 Compositions and methods for assessing cytotoxicity of single cells  
The invention provides a method of analyzing interactions between pairs of target and effector cells utilizing high-throughput screenings methods for profiling large numbers of single cells in...
9242240 Olefin metathesis catalysts and related methods  
The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to...
US20160020436 Safely Ingestible Batteries  
A battery for use in electronic devices and which is safely ingested into a body and a related method of making the battery. The battery includes an anode, a cathode and a quantum tunneling...
US20160018344 SENSOR AND METHOD OF DETECTING AN ANALYTE USING 19F NMR  
A sensor including a fluorinated receptor can be used to identify an analyte through shift in 19F NMR resonance of the receptor when the receptor interacts with the analyte.
US20160017794 Engine Reformer Systems For Lower Cost, Smaller Scale Manufacturing Of Liquid Fuels  
A reformer-liquid fuel manufacturing system that utilizes an engine to generate hydrogen-rich gas is disclosed. The engine operates at very rich conditions, such as 2.5<φ<4.0. In doing so, it...
US20160017393 DIRECTED ENDONUCLEASES FOR REPEATABLE NUCLEIC ACID CLEAVAGE  
The invention provides compositions and methods for repeatable directed endonucleases (RDEs) and methods for repeatedly, and specifically cleaving DNA offset from the RDE's DNA recognition...
US20160017283 SYSTEMS AND METHODS FOR CULTURING EPITHELIAL CELLS  
The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the...
US20160016321 Systems and Methods for Compiling Robotic Assemblies  
Systems and methods to systematize the development of machines using inexpensive, fast, and convenient fabrication processes are disclosed. In an embodiment, a robot compiler generates a...
9238716 Conjugated lipomers and uses thereof  
The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”)...
US20160014393 Methods and Apparatus for Virtual Sensor Array  
A time-of-flight camera images an object around a corner or through a diffuser. In the case of imaging around a corner, light from a hidden target object reflects off a diffuse surface and travels...
US20160014335 IMAGING SYSTEM FOR IMMERSIVE SURVEILLANCE  
Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a...
US20160013867 DEVICES AND TECHNIQUES FOR INTEGRATED OPTICAL DATA COMMUNICATION  
Devices and techniques for integrated optical data communication. A method of encoding symbols in an optical signal may include encoding a first symbol by injecting charge carriers, at a first...
US20160011175 Methods for Identifying Stem Cells by Detecting Fluorescence of Cells and Syncytia  
Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting...
US20160011135 DEVICES AND METHODS FOR DETERMINATION OF SPECIES INCLUDING CHEMICAL WARFARE AGENTS  
The present invention generally provides devices, systems, and methods for determination of one or more analytes. The analyte may be determined by monitoring, for example, a change in an...
US20160010982 Laser Speckle Photography for Surface Tampering Detection  
In one embodiment, a method comprises projecting, from a projector, a diffused on an object. The method further includes capturing, with a first camera in a particular location, a reference image...
US20160009746 TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS  
The current application describes tungsten oxo alkylidene complexes for olefin metathesis.
US20160009657 AMINE-CONTAINING LIPIDS AND USES THEREOF  
Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described....
US20160008802 HIGHLY Z-SELECTIVE OLEFIN METATHESIS  
The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.
US20160008451 NANOPARTICLE-BASED COMPOSITIONS  
Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the...
US20160007935 Methods and apparatus for measuring physiological parameters  
A sensor system includes one or more gyroscopes and one or more accelerometers, for measuring subtle motions of a user's body. The system estimates physiological parameters of a user, such as...
9236556 Polymer composite actuator and generator driven by water gradients  
Water-responsive composite materials are provided containing a polymeric matrix and a water-responsive gel integrated into the polymeric matrix. The water-responsive gel can include a polyol or an...
9234482 Ultra-high efficiency alcohol engines using optimized exhaust heat recovery  
Engine system using alcohol Rankine heat recovery where the engine heat converts alcohol into hydrogen-rich gas which is then introduced into the engine cylinders. The engine system includes a...
9233912 Devices and methods for crystallization  
The invention in some aspects relates to devices and methods for nucleating crystals under controlled conditions. In some aspects of the invention, devices and methods are provided for continuous...
9233287 Force-sensing net  
In exemplary implementations of this invention, a basketball net or flat net measures the translational kinetic energy of a ball that passes through an aperture in the net or impacts the net. The...
9233072 Adjuvant incorporation in immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
US20160006813 Sensor Platform for Context-Aware Experimental Research  
A platform for context-aware experimentation includes a housing for one or more sensors for obtaining data pertaining to an on-going experiment, a communications subsystem for transmitting data...