Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20170002266 PREPARATION OF NANORODS  
A method of preparing a core-shell nanorod can include growing a shell of a core-shell nanorod (M1X1)M2X2 in a solution through a slow-injection of M2 precursor solution and X2 precursor solution,...
US20170000899 RECEPTOR-TARGETED NANOPARTICLES FOR ENHANCED TRANSCYTOSIS MEDIATED DRUG DELIVERY  
Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric...
US20170000888 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS  
Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can...
9538056 High-resolution surface measurement systems and methods  
This disclosure provides systems, devices, and methods for capturing and measuring surface topography. This disclosure provides a high resolution retrographic sensor comprising a volume of...
9537759 Multi-path data transfer using network coding  
Techniques, devices, systems, and protocols are disclosed herein that relate to data transfer between communication nodes via multiple heterogeneous paths. In various embodiments, network coding...
9537473 Digitally assisted analog dynamic range enhancer  
A circuit for expanding a dynamic range. In one embodiment, the circuit includes: a transducer generating a signal current on an output terminal in response to a physical quantity, the signal...
9536698 Systems and methods for particle pulse modulation  
Methods and apparatus for modulating a particle pulse include a succession of Hermite-Gaussian optical modes that effectively construct a three-dimensional optical trap in the particle pulse's...
9533167 System and method for manipulation of devices using magnetic fields  
A system and method for manipulating devices, such as a medical implant arranged within a subject, is provided. For non-invasive manipulation of a medical implant, a subject having a...
9532956 PH sensitive biodegradable polymeric particles for drug delivery  
The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles...
US20160380481 WIRELESS NON-RADIATIVE ENERGY TRANSFER  
Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a...
US20160380404 METHOD AND APPLICATIONS OF THIN-FILM MEMBRANE TRANSFER  
The disclosure relates to method and apparatus for micro-contact printing of micro-electromechanical systems (“MEMS”) in a solvent-free environment. The disclosed embodiments enable forming a...
US20160377631 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF  
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell...
US20160376293 NICKEL PRE-CATALYSTS AND RELATED COMPOSITIONS AND METHODS  
Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.
US20160376150 CONDUCTIVE AEROGEL  
Electrically conductive aerogel and methods of making the same are disclosed. A solution is provided. The solution is cured to form a polymer. The polymer is carbonized to form the conductive aerogel.
US20160375149 IN VIVO TARGETING OF CELLS WITH LIGAND-CONJUGATED PARTICLES  
The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest over a period of time.
US20160375006 USES OF PARALOG-SELECTIVE INHIBITORS OF GSK3 KINASES  
The present disclosure provides methods of using GSK3α-selective inhibitors for treating Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual...
9530965 Conductive polymer films grafted on organic substrates  
One aspect of the invention relates to a linker-free, one-step method of grafting polymer films onto organic substrates, and the films obtained by such a method. In certain embodiments, the...
9530763 Monolithic integration of CMOS and non-silicon devices  
A method includes attaching a partially processed CMOS wafer to a second wafer to produce a combined wafer. The second wafer comprises a first region including a material different from silicon....
9529590 Processor for large graph algorithm computations and matrix operations  
A node processor and method for performing matrix operations includes storing, in memory, non-zero matrix elements of a first sparse matrix, non-zero matrix elements of a second sparse matrix, and...
9529150 Waveguide formation using CMOS fabrication techniques  
Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon...
9528817 Systems and methods for phase measurements  
Preferred embodiments of the present invention are directed to systems for phase measurement of biological materials which can be applied to the fields of, for example, cellular physiology and...
9528145 Rare earth spatial/spectral barcodes for multiplexed biochemical testing  
Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals...
9528144 Rare earth spatial/spectral microparticle barcodes for labeling of objects and tissues  
Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission...
9528082 Modular platform for multi-tissue integrated cell culture  
The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of...
9527741 Compositions comprising enhanced graphene oxide structures and related methods  
Embodiments described herein generally relate to compositions comprising a graphene oxide species. In some embodiments, the compositions advantageously have relatively high oxygen content, even...
9526800 Cancer-related extracellular matrix signatures and related methods and products  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
9526702 Vaccine nanotechnology  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune...
US20160372300 Systems and Methods for Particle Pulse Modulation  
Methods and apparatus for modulating a particle pulse include a succession of Hermite-Gaussian optical modes that effectively construct a three-dimensional optical trap in the particle pulse's...
US20160370474 SYSTEM AND METHOD TO IMPROVE IMAGE QUALITY OF EMISSION TOMOGRAPHY WHEN USING ADVANCED RADIONUCLIDES  
A method and system for acquiring a series of medical images includes a plurality of detectors configured to be arranged to acquire gamma rays emitted from a subject as a result of an advanced...
US20160370374 GLYCOMIC PATTERNS FOR THE DETECTION OF DISEASE  
This invention relates, in part, to methods and products for the detection of cancer, such as prostate cancer or multiple myeloma. This invention also relates, in part, to methods and products for...
US20160370356 PAPER-BASED IMMUNOASSAY WITH POLYMERIZATION-BASED SIGNAL AMPLIFICATION  
Disclosed herein are paper-based immunoassays useful for the detection of analytes, kits for the same and methods of using the same.
US20160367946 DYE SENSITIZED PHOTOACTIVE SURFACES  
Upon light irradiation, a dye sensitized photoactive surfaces can undergo hydrophobic to hydrophilic conversion in both in air and oil environments.
US20160367755 SYSTEM AND METHOD FOR NEUROENDOCRINE CONTROL  
The present invention relates to systems and methods for detecting and regulating neuroendocrine control. The systems involve measurement of real time pulsatile endocrine hormone levels in a...
US20160367693 Selective Arylation of Dichalcogenides in Biomolecules  
Disclosed are chemical transformations for the conjugation of unprotected peptide biomolecules. The processes feature several significant advantages over existing methods of peptide modification,...
US20160367686 ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF  
Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a...
9525330 Electropermanent magnet-based motors  
An electropermanent linear actuator has a stator, forcer, drive circuitry, and feedback control mechanism. The stator includes at least one electropermanent magnet with a coil that passes current...
9525071 Flexible high-voltage thin film transistors  
A flexible high-voltage thin-film transistor includes a gate electrode, a source electrode, a drain electrode, a dielectric layer, and a flexible semiconductor layer. The flexible semiconductor...
9523152 Metallic dielectric photonic crystals and methods of fabrication  
A metallic-dielectric photonic crystal is formed with a periodic structure defining a plurality of resonant cavities to selectively absorb incident radiation. A metal layer is deposited on the...
US20160366724 MULTIFUNCTIONAL CNT-ENGINEERED STRUCTURES  
Various applications for structured CNT-engineered materials are disclosed herein. In one application, systems are disclosed, wherein a structured CNT-engineered material forms at least part of an...
US20160365216 PYROLYZED POROUS CARBON MATERIALS AND ION EMITTERS  
Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described
US20160364521 METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR  
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a...
US20160361109 METHODS FOR INDUCING ELECTROPORATION AND TISSUE ABLATION  
The invention encompasses a method of inducing a high permeability state in a cell membrane and a method for ablating a target tissue wherein the method comprises applying an electroporation pulse...
9517030 Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties  
A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to...
US20160359118 [2.2]Paracyclophane-Derived Donor/Acceptor-Type Molecules for OLED Applications  
Disclosed are [2.2]paracyclophane-derivative compounds and related polymers that are useful as stable, efficient, blue-light emitting compounds for OLED applications.
US20160358077 SYSTEM AND METHOD FOR QUANTIFYING AND PRESENTING INFORMATION REPRESENTATIVE OF TECHNOLOGICAL IMPROVEMENTS IN A TARGET TECHNOLOGICAL DOMAIN BASED ON PATENT METRICS  
Embodiments are disclosed herein for quantifying and presenting information representative of technological improvements in a technological domain based on patent metrics that may include...
US20160356890 Methods and Apparatus for Three-Dimensional (3D) Imaging  
A method of imaging a scene includes estimating multiple three-dimensional (3D) representations, each of which corresponds to a respective portion of the scene. Neighboring portions of the scene...
US20160355918 ACTIVATED ALUMINUM FUEL  
Aluminum can be used as a fuel source when reacted with water if its native surrounding oxide coating is penetrated with a gallium-based eutectic. When discrete aluminum objects are treated in a...
US20160355849 METHODS FOR CONVERSION OF FOOD WASTE TO CHEMICAL PRODUCTS  
Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and...
US20160355797 SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of...
US20160355796 COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to...