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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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8999132 Desalination and purification system  
A liquid electrolyte can be desalinated and purified using a system that includes a first electrode and a configuration selected from (a) a second electrode and at least one distinct ion-selective...
8997711 Fuel management system for variable ethanol octane enhancement of gasoline engines  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
US20150095841 SYSTEMS AND METHODS FOR COMPOSABLE ANALYTICS  
Systems, methods, and computer readable medium are provided for a composable analytics environment. A graphical module repository is provided that consists of a plurality of graphical modules that...
US20150094255 Lectin Conjugates for Mucin Hydration  
The invention provides, inter alia, conjugates of a hydratable polymer (such as PEG, polyethylene glycol) and a lectin (such as wheat germ agglutinin, WGA), compositions comprising these...
US20150093794 CELLULAR PRODUCTION OF GLUCARIC ACID  
The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate...
US20150093745 OPTOELECTRONIC DETECTION SYSTEM  
The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir...
US20150091061 PASSIVATION TECHNIQUE FOR WIDE BANDGAP SEMICONDUCTOR DEVICES  
A method of protecting a semiconductor structure from water and a semiconductor structure formed by the method. The semiconductor structure includes a wide-bandgap semiconductor material in which...
8994688 Flat panel display with integral touch screen  
There are disclosed display devices with integral touch screens and methods for operating display panels. A display panel may include a plurality of pixels, each pixel controlled by a...
8993745 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
8993233 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8992985 Core-shell magnetic particles and related methods  
The invention provides core-shell magnetic particles comprising a magnetic core and a functional shell, methods for making same, methods of separation using same, methods for using same, and...
8992466 Controlled needle-free transport  
A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with...
US20150087991 APPLICATION SPECIFIC INTEGRATED CIRCUIT WITH COLUMN-ROW-PARALLEL ARCHITECTURE FOR ULTRASONIC IMAGING  
An ultrasonic imaging system is described in which a column-row-parallel architecture is provided at the circuit level of an ultrasonic transceiver. The ultrasonic imaging system can include a N×M...
US20150087055 ANALOG AND MIXED-SIGNAL COMPUTATION AND CIRCUITS IN LIVING CELLS  
Provided herein are molecular analog gene circuits that exploit positive and negative feedback to implement logarithmically linear sensing, addition, subtraction, and scaling thus enabling...
US20150086668 Extruder Feed System  
Extruder feed system. The system includes a pair of spaced-apart, internally and oppositely threaded rotatable elements for receiving and engaging a plastic filament material. An electric motor...
US20150086599 Self Assembled Films for Protein and Drug Delivery Applications  
Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and...
US20150086565 CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
US20150086516 Methods, Compositions, and Devices to Induce Mobilization and Recruitment of Progenitor Cells  
Methods, compositions and systems are provided for mobilizing and recruiting progenitor, progenitor-like cells, and/or stem cells to a target site, such as an in vivo site in a patient in need of...
US20150083032 Combustion System  
Combustion system. The system includes a combustor generating a combustion gas and a splitter for receiving the combustion gas and dividing the combustion gas into first and second gas streams. A...
US20150082582 Methods and Apparatus for Robotic Zipper  
A robotic zipper system for joining and separating zipper halves of a zipper tape. A chassis retains an actuator that drives a zipper slide geometry along the zipper tape to join or separate the...
8989303 Digital transmitter  
An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to...
8988754 Optical phased arrays with evanescently-coupled antennas  
An optical phased array formed of a large number of nanophotonic antenna elements can be used to project complex images into the far field. These nanophotonic phased arrays, including the...
8987217 Modified saponins for the treatment of fungal infections  
Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
8986999 Virus/nanowire encapsulation within polymer microgels for 2D and 3D devices for energy and electronics  
Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during...
8986988 Cell rolling separation  
The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and...
8986848 Coatings  
A hydrophilic coating can be applied to virtually any surface to produce a long-lasting, durable antifog effect. The coating includes a molecular-level blend of hydrophilic polymers. The coating...
8986814 Superhydrophobic surfaces  
Surfaces having a hierarchical structure—having features of both microscale and nanoscale dimensions—can exhibit superhydrophobic properties and advantageous condensation and heat transfer...
8986809 Methods and apparatus for digital composites  
In exemplary implementations of this invention, a digital material comprising many discrete units is used to fabricate a sparse structure. The units are reversibly joined by elastic connections....
8986780 Method and apparatus for depositing LED organic film  
The disclosure relates to a method for depositing an organic film layer on a substrate. In one implementation a method to deposit organic film by generating vaporized organic particles; streaming...
US20150082468 INVERSE PATTERNING PROCESS FOR THREE-DIMENSIONAL MULTI-COMPARTMENTAL MICRO-ORGANIZATION OF MULTIPLE CELL TYPES  
The invention features an “inverse patterning” or “Intaglio-Void/Embed-Relief Topographic (In VERT) molding” manufacturing process for generating high-resolution three-dimensional (3D)...
US20150081393 PRODUCT PROMOTION OPTIMIZATION SYSTEM  
A system that determines promotional pricing for a product and for an objective function receives a non-linear time-dependent optimization problem for the product, where the non-linear problem...
US20150080847 MEDICAMENT, METHOD, AND DRUG DELIVERY DEVICE FOR TREATMENT OF OVARIAN CANCER  
Drug delivery devices, medicaments, and methods are provided for the intraperitoneal treatment of ovarian cancer. An implantable device for drug delivery includes an elongated, flexible device...
US20150080405 COMPOUNDS, COMPOSITIONS AND METHODS OF AGELASTATIN ALKALOIDS  
The present invention, among other things, provides compounds, compositions and methods for treatment of cancer. In some embodiments, the present invention provides methods for treating blood...
US20150080234 Cell Patterning  
The present disclosure provides technologies for achieving cell patterning, as well as patterned cell arrays achieved with such technologies. Provided apparatus and methods are useful in a variety...
US20150079681 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20150079645 MICROBIAL ENGINEERING FOR THE PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES  
Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to...
US20150079282 Conductive Polymer Films Grafted on Organic Substrates  
One aspect of the invention relates to a linker-free, one-step method of grafting polymer films onto organic substrates, and the films obtained by such a method. In certain embodiments, the...
US20150079113 MENA AND ALPHA5 INTEGRIN INTERACTION  
Methods are provided for treating invasion of a tumor or metastasis of a tumor in a subject comprising administering to the subject an agent which inhibits the interaction of Mena with an alpha5...
US20150076632 METHOD AND APPARATUS FOR RELEASE-ASSISTED MICROCONTACT PRINTING OF MEMS  
The disclosure provides methods and apparatus for release-assisted microcontact printing of MEMS. Specifically, the principles disclosed herein enable patterning diaphragms and conductive...
US20150075989 DEVICES AND METHODS USING POROUS MEMBRANES FOR OIL-WATER EMULSION SEPARATION  
The invention provides methods and devices that use membranes to separate oil/water mixtures. The methods and devices have a wide range of applications, including deep seep oil exploration, oil...
8983874 Method and system for micropayment transactions  
A micropayment system and method is presented for a payor U to establish payment to payee M for a transaction T, which typically has a very low value TV. The micropayment scheme minimizes the...
8983581 System and method for large field of view, single cell analysis  
A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical...
8983198 Compressive sensing with local geometric features  
Methods and apparatuses for compressive sensing that enable efficient recovery of features in an input signal based on acquiring a few measurements corresponding to the input signal. One method of...
8983019 Superwetting surfaces for diminishing leidenfrost effect, methods of making and devices incorporating the same  
Textured surface for increasing Leidenfrost temperature. The texture comprises of surface features over multiple length scales—from micro to nanoscale—wherein the features at each length scale...
8983011 Cross technology interference cancellation  
In one aspect, a method for mitigating an effect of an interfering radio signal at a multiple antenna receiver includes forming an estimate of a relationship of the interfering signal among...
8982450 Methods and apparatus for broadband frequency comb stabilization  
Feedback loops can be used to shift and stabilize the carrier-envelope phase of a frequency comb from a mode-locked fibers laser or other optical source. Compared to other frequency shifting and...
8982363 Method and apparatus to determine depth information for a scene of interest  
Depth information about a scene of interest is acquired by illuminating the scene, capturing reflected light energy from the scene with one or more photodetectors, and processing resulting...
8981086 Phosphine-ligated palladium sulfonate palladacycles  
Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described...
8980926 2-aminoindole compounds and methods for the treatment of malaria  
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the...
8978535 Articulating protective system for resisting mechanical loads  
Articulating protective systems for resisting mechanical loads and related methods are generally described. The protective structures described herein can incorporate one or more features that...