Patents and Patent Applications from Massachusetts Institute of Technology MIT


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9273307 Global transcription machinery engineering  
The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.
9272022 Compositions and methods for treating cancer and modulating stress granule formation  
The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase...
US20160056309 METHOD AND OPTOELECTRONIC STRUCTURE PROVIDING POLYSILICON PHOTONIC DEVICES WITH DIFFERENT OPTICAL PROPERTIES IN DIFFERENT REGIONS  
Method and structural embodiments are described which provide an integrated structure using polysilicon material having different optical properties in different regions of the structure.
US20160056010 SYSTEMS AND METHODS FOR PARTICLE PULSE MODULATION  
Methods and apparatus for modulating a particle pulse include a succession of Hermite-Gaussian optical modes that effectively construct a three-dimensional optical trap in the particle pulse's...
US20160055124 SYSTEMS AND METHODS FOR LOW-RANK MATRIX APPROXIMATION  
Systems and methods for generating a low-rank approximation of a matrix are provided. The various systems and methods may identify at least a first set of right singular vectors and a first set of...
US20160054520 METHOD AND STRUCTURE PROVIDING A FRONT-END-OF-LINE AND A BACK-END-OF-LINE COUPLED WAVEGUIDES  
An integrated structure and method of formation provide a lower level waveguide having a core of a first material and a higher level waveguide having a core of a second material and a coupling...
US20160052261 Methods and Apparatus for Handheld Inkjet Printer  
A handheld inkjet printer includes an inkjet print head and a tip. One or more sensors measure the position of points on a curved surface that are physically touched by the tip while the tip is...
US20160051353 High-Throughput Organ-Targeted Microinjection System  
Automatic system for efficient delivery of biologics into target organs of zebrafish larvae for high-throughput in vivo screening. The system includes a reservoir containing zebrafish larvae...
9271123 Wireless reliability architecture and methods using network coding  
Network-coding-enabled reliability architectures and techniques are provided that are capable of enhancing data transfer reliability and efficiency in next generation wireless networks. In some...
9270895 Methods and apparatus for true high dynamic range imaging  
When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital...
9270412 Permute codes, iterative ensembles, graphical hash codes, and puncturing optimization  
Described herein are new error-correction (channel) codes: permute codes, iterative ensembles of permute and spinal codes, and graphical hash codes. In one aspect, a wireless system includes an...
9269144 Method and apparatus for motion correction and image enhancement for optical coherence tomography  
Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for...
9268025 Fast transform based offset determination  
An offset estimator (e.g., a time delay, a spatial image offset, etc.) makes use of a transform approach (e.g., using Fast Fourier Transforms). The sparse nature of a cross-correlation is...
9267937 System for screening particles  
Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue...
9267908 Devices and methods for determination of species including chemical warfare agents  
The present invention generally provides devices, systems, and methods for determination of one or more analytes. The analyte may be determined by monitoring, for example, a change in an...
9267118 Methods for identifying bacterial strains that produce L-tyrosine  
The invention relates to high-throughput screens for identifying bacterial strains capable of L-tyrosine production.
9266260 Precision continuous stamp casting method for roll-based soft lithography  
Method for casting a continuous cylindrical polymer stamp. The method includes depositing a first layer of a fluid polymer on the inside of a rotatable drum and rotating the drum for a selected...
9265764 Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders  
Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this...
9265747 Platinum (IV) complexes for use in dual mode pharmaceutical therapy  
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk...
9265461 Identification techniques and device for testing the efficacy of beauty care products and cosmetics  
A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin,...
US20160046590 SONIC HEDGEHOG MODULATORS  
Sonic Hedgehog modulators and methods of use thereof are provided for.
US20160045120 SYSTEMS AND METHODS FOR SPIKE SORTING  
In a system for unsupervised spike sorting, features/dimensions suitable for clustering of the recorded spike signal data are identified, and the feature space is scaled according to the computed...
9264147 Method and apparatus for phase shift keyed optical communications  
A burst-mode phase shift keying (PSK) communications system according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical...
9263614 In-fiber filament production  
In a fiber there is provided a fiber matrix material having a fiber length; and an array of isolated in-fiber filaments that extend the fiber length. The in-fiber filaments are disposed at a...
9261496 Device for high throughput investigations of multi-cellular interactions  
Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device...
US20160044218 HIGH-RESOLUTION SURFACE MEASUREMENT SYSTEMS AND METHODS  
This disclosure provides systems, devices, and methods for capturing and measuring surface topography. This disclosure provides a high resolution retrographic sensor comprising a volume of...
US20160043800 DESIGN OF A FREE-SPACE OPTICAL COMMUNICATION MODULE FOR SMALL SATELLITES  
Communication bottlenecks, particularly in the downlink direction, are a common problem for many CubeSat developers. As described herein, a CubeSat module for a CubeSat comprises an optical...
US20160043449 RECYCLING CAR BATTERIES FOR PEROVSKITE SOLAR CELLS  
An efficient perovskite solar cells can be synthesized from used car batteries by using both the anodes and cathodes of car batteries as material sources for the synthesis of lead iodide...
US20160043270 ENGINEERED BAND GAPS  
An optoelectronic device as well as its methods of use and manufacture are disclosed. In one embodiment, an optoelectronic device includes first and second semiconducting atomically thin layers...
US20160040657 Self-Folding Machines  
A self-folding machine comprises a laminate including a flexible layer with a first side and a second side; a first rigid layer including at least one gap laminated to the first side of the...
US20160040218 Selective Purification of RNA and RNA-Bound Molecular Complexes  
Disclosed are methods for isolating a target nucleic molecule of interest from a sample. The methods include contacting a sample comprising a target nucleic molecule of interest with at least one...
US20160040212 Methods for the Detection of DNA-RNA Proximity in Vivo  
Disclosed is a method for detecting spatial proximity relationships between RNA and DNA molecules in a cell. The method includes: providing a sample of RNA and DNA wherein the RNA and fDNA have...
US20160039902 CHANNELRHODOPSIN VARIANTS AND USES THEREOF  
CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and...
US20160038632 Adaptive Drug Delivery from an Artificial Polymer Skin with Tunable Properties for Tissue Engineering  
The present invention provides, among other things, a composite device comprised of a porous polymer membrane carrying active growth factors. Composite devices are characterized by an ability to...
US20160038609 Multistage Nanoparticles  
Multistage nanostructures, e.g., for delivery of agents such as imaging agents and therapeutic agents to tumor vasculature.
US20160038415 LIPID VESICLE COMPOSITIONS AND METHODS OF USE  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
9256202 System, method and apparatus for phase-coded multi-plane microscopy  
A volume holographic imaging system enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) object. The 4D source object is illuminated to emit or scatter an optical...
9255519 Fuel management system for variable ethanol octane enhancement of gasoline engines  
Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management...
9254500 Aerosol generation for stable, low-concentration delivery  
A feed aerosol comprising detectable particles is injected into a mix-enhancing swirler. Diluting gas is also injected into the mix-enhancing swirler and mixed with the feed aerosol in a swirling...
9254496 Articles for manipulating impinging liquids and methods of manufacturing same  
This invention relates generally to an article that includes a non-wetting surface having a dynamic contact angle of at least about 90°. The surface is patterned with macro-scale features...
US20160034820 SYSTEMS AND METHODS FOR DISTRIBUTED SOLUTION OF OPTIMIZATION PROBLEMS  
A framework is presented for designing a class of distributed, asynchronous optimization algorithms realized as signal processing architectures utilizing various conservation principles. The...
US20160033485 COMPOSITIONS AND METHODS FOR CANCER DIAGNOSIS  
The present disclosure provides compositions comprising a food product, non-pathogenic microorganism, kits, methods of diagnosing a tumor in a subject, methods of quantifying the number of cancer...
US20160033212 ENHANCED FLOW BOILING HEAT TRANSFER IN MICROCHANNELS WITH STRUCTURED SURFACES  
A two-phase microchannel heat sink can be a fluid channel including a bottom wall including a superhydrophilic surface with microstructures and a side wall including a surface that is hydrophobic...
US20160032350 Microfluidic Microbe Detection and Isolation  
A method and microfluidic device useful for isolating microbes from a blood sample which includes introducing the blood sample into the sample inlet of a spiral microfluidic device; and...
US20160032288 RNA SEQUENCE-SPECIFIC MEDIATORS OF RNA INTERFERENCE  
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23...
US20160031931 SOLID PHASE PEPTIDE SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS  
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that...
US20160031837 COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF  
The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present...
US20160031824 BENZIMIDAZOLE DERIVATIVES AND USES THEREOF  
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled...
US20160030598 Reaction-Based Fluorescent Probes for Detecting Zinc  
Disclosed are compounds and methods useful in the detection of e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+....
US20160030360 MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS  
Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The...