Patents and Patent Applications from Massachusetts Institute of Technology MIT


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9382960 Beam-based nonlinear spring  
Nonlinear spring. In one embodiment, the spring includes two opposed curved surfaces curving away from one another. A flexible cantilever member is disposed between the two opposed curved surfaces...
9382281 Nickel pre-catalysts and related compositions and methods  
Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.
9382210 Articles and methods comprising persistent carbenes and related compositions  
Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g.,...
9381642 Wearable robot assisting manual tasks  
A wearable robotic system assists a wearer in performing manual tasks. One or more robotic arms are mounted to a wearer, and an sensor monitors the orientation(s) (e.g., position and movement) of...
9381528 Articles for manipulating impinging liquids and methods of manufacturing same  
This invention relates generally to an article that includes a non-wetting surface having a dynamic contact angle of at least about 90°. The surface is patterned with macro-scale features...
9381477 Microfluidic synthesis of organic nanoparticles  
The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful...
9381253 Drug delivery polymer and uses thereof  
Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods...
US20160190943 Switched-Capacitor Split Drive Transformer Power Conversion Circuit  
A split drive transformer (SDT) and use of such a transformer in a power converter is described. The power converter includes a power and distributor circuit configured to receive one or more...
US20160190855 ADAPTIVE CONTROL OF WIRELESS POWER TRANSFER  
A method for wireless power transfer adapts to changing configuration of receivers, including changes in number of, location and/or orientation of, magnetic coupling to, and load of circuits...
US20160190558 SULFUR NANOSPONGE CATHODE FOR LITHIUM-SULFUR BATTERY AND METHODS OF MANUFACTURE THEREOF  
The present invention is directed to lithium-sulfur batteries exhibiting a high capacity, high cycle life with low production cost and improved safety.
US20160187578 In-Fiber Filament Production  
In a fiber there is provided a fiber matrix material having a fiber length. A circumferential array of in-fiber filaments extend the fiber length. Each filament in the array is separated from...
US20160187536 NON-VOLATILE PHOTONIC MATERIAL AND PRODUCTION METHOD OF THE SAME  
A photonic material capable of reflecting part of the light rays in a wavelength region from near-ultraviolet light to near-infrared light. The photonic material contains a block copolymer...
US20160187323 SYSTEM FOR SCREENING PARTICLES  
Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue...
US20160186213 DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors...
US20160186163 ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS  
The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
9380221 Methods and apparatus for light field photography  
In exemplary implementations of this invention, a light field camera uses a light field dictionary to reconstruct a 4D light field from a single photograph. The light field includes both angular...
9377447 Methods and apparatus for artificial olfaction  
In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this...
9376623 Compositions including polymers aligned via interchain interactions  
The present invention provides compositions, devices and methods related to the alignment of materials including polymers. In some cases, the present invention comprises the assembly of molecules...
9375160 Systems and methods for model-based estimation of cardiac output and total peripheral resistance  
The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in...
US20160181987 Phase-Switched Impedance Modulation Amplifier  
Described is a phase-switched phase-switched, impedance modulation amplifier (PSIM). The PSIM has an input that can be coupled to a source and an output that can be coupled to a load. The PSIM...
US20160181986 TUNABLE MATCHING NETWORK WITH PHASE-SWITCHED ELEMENTS  
Described is a phase-switched tunable impedance matching network (PS-TMN). The PS-TMN has an input that can be coupled to a source and an output that can be coupled to a load. The PS-TMN includes...
US20160181458 Cross-Talk Suppression in Geiger-Mode Avalanche Photodiodes  
An avalanche photodiode detector is provided with a substrate including an array of avalanche photodiodes. An optical interface surface of the substrate is arranged for accepting external input...
US20160178597 Systems and Methods Related to Optical Nanosensors Comprising Photoluminescent Nanostructures  
Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.
US20160176933 MUTANT CHANNELRHODOPSINS WITH ALTERED ION SELECTIVITY  
The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.
US20160176128 Extremely Compliant Yet Tough Hydrogel Systems as Ultrasound Transmission Agents  
Method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy....
US20160175491 Local Drug Delivery Devices and Methods for Treating Cancer  
Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting...
US20160175483 Hydrogels for Vocal Cord and Soft Tissue Augmentation and Repair  
The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation,...
US20160175462 DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
9374020 Stacked switched capacitor energy buffer circuit architecture  
Described herein is a stacked switched capacitor (SSC) energy buffer circuit architecture and related design and control techniques.
9373033 Assisted surveillance of vehicles-of-interest  
A computer-implemented image processing method includes accessing image data representing a plurality of images of a plurality of vehicles and reading a data model representing a predefined...
9371173 Self-lubricating surfaces for food packaging and food processing equipment  
In certain embodiments, the invention relates to an article having a liquid-impregnated surface. The surface includes a matrix of solid features (e.g., non-toxic and/or edible features) spaced...
9370551 Compositions and methods of treating head and neck cancer  
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features...
US20160172714 Multi-Element Liquid Metal Battery  
An electrochemical cell includes a negative electrode having at least two active metals, a positive electrode having a metal or alloy, and an electrolyte having a cation of each of the active...
US20160172180 METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY  
A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design...
US20160171149 METHODS AND APPARATUS FOR AUTOMATED DESIGN OF SEMICONDUCTOR PHOTONIC DEVICES  
A photonic design automation (PDA) tool to facilitate design of semiconductor photonic devices is described. In one example, the PDA tool includes a process design library including one or more...
US20160170285 OPTOELECTRONIC FILTER  
An optoelectronic filter having at least one input and an output includes a modulator circuit having at least first and second inputs with a first one of the modulator circuit inputs adapted to...
US20160169810 SELECTIVE DETECTION OF ALKENES OR ALKYNES  
A detector can detect an analyte including a carbon-carbon multiple bond moiety and capable of undergoing Diels-Alder reaction with a heteroaromatic compound having an extrudable group. The...
US20160168594 ONCOGENIC MODELS BASED ON DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20160168165 MYC MODULATORS AND USES THEREOF  
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating...
US20160168162 LUMINESCENT COMPOUND AND ELECTROLUMINESCENT DEVICE EXHIBITING THERMALLY ACTIVATED DELAYED FLUORESCENCE  
A chemical compound is provided having a structure that includes at least one donor moiety covalently bonded to at least one acceptor moiety. For example, the compound may include an...
US20160167306 SYSTEMS AND METHODS OF HIERARCHICAL MATERIAL DESIGN FOR ADDITIVE FABRICATION  
According to some aspects, a method of designing a three-dimensional object based on a shape of the object, the object to be fabricated via additive fabrication from a plurality of materials, is...
US20160166803 SYSTEMS AND METHODS FOR DELIVERING CHEMICAL AND ELECTRICAL STIMULATION ACROSS ONE OR MORE NEURAL CIRCUITS  
Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and...
9369541 Method and apparatus for implementing distributed content caching in a content delivery network  
Distributed content caching is implemented in an efficient, low cost manner within a content delivery network (CDN). In various embodiments, content is identified for caching at a number of...
9369255 Method and apparatus for reducing feedback and enhancing message dissemination efficiency in a multicast network  
Message dissemination speed is increased during multicast operations in a network by intelligently selecting one or more feedback time slots for use by destination nodes. In at least one...
9369005 Energy extraction  
This disclosure describes techniques and systems for extracting energy from the endocochlear potential (EP) in animal subjects (e.g., human subjects) and using the extracted energy to operate...
9367610 Knowledge registry systems and methods  
Systems and methods are disclosed that provide high-level, ontology-based analysis of low-level data stored within an unstructured key/value store. The systems and methods allow an analyst to make...
9366576 Detection of electromagnetic radiation using nonlinear materials  
An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate....
9365498 Inhibitors of histone deacetylase  
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described...
9365013 Multimaterial thermally drawn piezoelectric fibers  
Disclosed are fibers that include a composite of at least three different materials, where the at least three different materials include a conductor, an insulator, and a non-centrosymmetric...
9364513 Compositions and methods for promoting hemostasis and other physiological activities  
Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a...