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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20150065723 OLEFIN METATHESIS CATALYSTS AND RELATED METHODS  
The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to...
US20150065389 MULTI-WELL MICROPATTERNING BY ABLATION  
The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen...
US20150064791 Microfluidic-based Gene Synthesis  
A method for synthesizing long DNA constructs from oligonucleotide precursors directly within a microfluidic device uses several oligonucleotides at once. A precursor mix containing at least two...
US20150064770 TUNING BACTERIOPHAGE HOST RANGE  
Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.
US20150064471 Seed for Metal Dichalcogenide Growth by Chemical Vapor Deposition  
A metal dichalcogenide layer is produced on a transfer substrate by seeding F16CuPc molecules on a surface of a growth substrate, growing a layer (e.g., a monolayer) of a metal dichalcogenide via...
US20150064155 METHODS FOR TREATMENT OF CERVICAL INSUFFICIENCY  
Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in a subject are provided herein. The methods described herein involve...
US20150064138 TUNING MICROBIAL POPULATIONS WITH PROGRAMMABLE NUCLEASES  
Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as,...
8969831 Excitation enhancement and extraction enhancement with photonic crystals  
Disclosed herein is a system for stimulating emission from at least one an emitter, such as a quantum dot or organic molecule, on the surface of a photonic crystal comprising a patterned...
8969353 Aminoalcohol lipidoids and uses thereof  
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting...
8969295 Identifying and modulating molecular pathways that mediate nervous system plasticity  
The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in...
8969183 Method for producing thin layers of crystalline or polycrystalline materials  
Method for making thin crystalline or polycrystalline layers. The method includes electrochemically etching a crystalline silicon template to form a porous double layer thereon, the double layer...
8968207 Methods and apparatus for visually representing a cardiac status of a patient  
Method and apparatus are provided for computing signals related to cardiac output from physiologic input signals related to circulatory pressures or flows. Method and apparatus are provided for...
US20150057315 Methods for Treatment of 16P11.2 Microdeletion Syndrome  
Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mGluR inhibitors, including mGluR antagonists that include mGluR negative allosteric...
US20150056220 METHODS FOR IDENTIFICATION OF SITES FOR IGG CONJUGATION  
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and...
US20150053337 Carrier-Substrate Adhesive System  
A system and method for creating three-dimensional nanostructures is disclosed. The system includes a substrate bonded to a carrier using a bonding agent. The bonding agent may be vaporizable or...
US20150053266 Internally-Heated Thermal and Externally-Cool Photovoltaic Cascade Solar Energy System for Full Solar Spectrum Utilization  
A single-stack, solar power receiver comprising both a thermal absorber layer and a photovoltaic cell layer. The stack includes an aerogel layer, that is optically transparent and thermally...
8966411 Standardized topographical arrangements for template regions that orient self-assembly  
This disclosure relates generally to systems and methods of providing standardized topographical configurations for template regions. In one embodiment, a set of array arrangements is selected....
8965468 Persistent-mode high-temperature superconducting shim coils to enhance spatial magnetic field homogeneity for superconducting magnets  
A persistent-mode High Temperature Superconductor (HTS) shim coil is provided having at least one rectangular shaped thin sheet of HTS, wherein the thin sheet of HTS contains a first long portion,...
8964901 Analog/digital co-design methodology to achieve high linearity and low power dissipation in a radio frequency (RF) receiver  
Receiver design techniques are provided that are capable of producing relatively efficient, linear radio frequency (RF) receivers. During a design process, components of an analog receiver chain...
8964881 Method and apparatus for high efficiency, high dynamic range digital RF power amplification  
A digital, radio frequency (RF) power amplifier includes first and second RF digital to analog converters (RF DACs) and a combiner to combine output signals of the first and second RF DACs. In at...
8963262 Method and apparatus for forming MEMS device  
The disclosure is generally directed to fabrication steps, and operation principles for microelectromechanical (MEMS) transducers. In one embodiment, the disclosure relates to a texture morphing...
8962073 Method and apparatus for controlling film deposition  
The disclosure relates to a method for depositing films on a substrate which may form part of an LED or other types of display. In one embodiment, the disclosure relates to an apparatus for...
8961877 High-throughput, whole-animal screening system  
Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the...
US20150051710 Model-Based Neuromechanical Controller For A Robotic Leg  
A model-based neuromechanical controller for a robotic limb having at least one joint includes a finite state machine configured to receive feedback data relating to the state of the robotic limb...
US20150051513 Nonlinear System Identification Techniques and Devices For Discovering Dynamic And Static Tissue Properties  
A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to...
US20150051139 Mucins as Antiviral Compounds  
The invention provides methods, and compositions for performing the methods, that reduce the diffusion or overall mobility of a virus on a surface, such as a biological surface using a purified...
US20150051112 ANTI-SIGMAS FOR PROGRAMMABLE TRANSCRIPTIONAL REGULATION  
The invention relates to anti-sigma factors (“anti-sigmas”) that bind to sigma factors and block activation of transcription. Anti-sigmas and their cognate sigma factors provide a highly effective...
US20150050723 Optoelectronic Detection System  
The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the...
US20150050717 BACTERIOPHAGES EXPRESSING ANTIMICROBIAL PEPTIDES AND USES THEREOF  
The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts,...
US20150049210 Method And Apparatus For Motion Coded Imaging  
An imaging apparatus and corresponding method according to an embodiment of the present invention enables high-resolution, wide-field-of-view, high sensitivity imaging. An embodiment of the...
US20150048676 WIRELESS NON-RADIATIVE ENERGY TRANSFER  
Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a...
8958666 Methods of achieving optimal communications performance  
A system includes an optical transmitter that outputs an optical signal having a substantially Gaussian waveform and an optical receiver that is optically coupled to the optical transmitter and...
8958470 Method and apparatus for sparse polynomial equalization of RF receiver chains  
A radio frequency (RF) receiver includes an analog receiver chain followed by digital circuitry for reducing nonlinear distortion components within an output signal of the analog receiver chain....
8957727 Asymmetric multilevel outphasing architecture for RF amplifiers  
A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port,...
8957197 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
RNA sequence-specific mediators of RNA interference
 
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23...
8957028 Red-shifted opsin molecules and uses thereof  
The invention, in some aspects, relates to compositions and methods for altering cell activity and function. The invention also relates, in part, to the use of light-activated ion pumps (LAIPs)...
8955368 Apparatus and method for aerosol collection and fluid analysis  
An apparatus for aerosol collection and fluid analysis includes a rotary motor, an aerosol-collection disk configured for mounting on the rotary motor, and a fluid-analysis disk that is also...
US20150047074 NANOBIONIC ENGINEERING OF ORGANELLES AND PHOTOSYNTHETIC ORGANISMS  
In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than −10 mV or greater than 10 mV contained within the organelle. In a preferred...
US20150045928 Automatic Process Control of Additive Manufacturing Device  
Automatic process control of additive manufacturing. The system includes an additive manufacturing device for making an object and a local network computer controlling the device. At least one...
US20150045570 PHOSPHINE-LIGATED PALLADIUM SULFONATE PALLADACYCLES  
Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described...
US20150045537 EXTRACELLULAR RELEASE OF LIPIDS BY PHOTOSYNTHETIC CELLS  
The invention relates to methods for harvesting macromolecules such as lipids and proteins by culturing in growth medium a photo synthetic cyanobacteria that secretes vesicles into the growth...
US20150045259 HIGH-THROUGHPUT PLATFORM FOR IN-VIVO SUB-CELLULAR SCREENS ON VERTEBRATE LARVAE  
High throughput system for in vivo screens on vertebrate larvae. The system includes a source of vertebrate larvae in a liquid medium and loading tube means for aspirating a larva. A detector...
US20150044804 CATHODE BUFFER MATERIALS AND RELATED DEVICES AND METHODS  
The present invention generally relates to cathode buffer materials and devices and methods comprising the cathode buffer materials.
US20150044463 Dynamic In-Fiber Particle Production With Precise Dimensional Control  
A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the...
US20150044234 MENAINV AND CANCER INVASION AND METASTASIS  
Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
US20150043602 PHOTONIC CRYSTAL SURFACE-EMITTING LASERS  
A photonic-crystal surface-emitting laser (PCSEL) includes a gain medium electromagnetically coupled to a photonic crystal whose energy band structure exhibits a Dirac cone of linear dispersion at...
8951776 Engineered microbes and methods for microbial oil production  
Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments,...
8951542 Lipid vesicle compositions and methods of use  
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar...
8951473 Devices and methods for determination of species including chemical warfare agents  
The application generally describes devices, systems, and methods for determination of one or more analytes. Embodiments described herein may be useful as sensors for analytes such as explosives,...
US20150038870 Multi-Channel Scalable EEG Acquisition System on a Chip with Integrated Patient Specific Seizure Classification and Recording Processor  
An integrated circuit chip and method for EEG monitoring. In one embodiment, the integrated circuit chip includes an Analog Front End cell in communication with an electrode and a Classification...