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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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8916683 Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials  
Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating...
US20140371610 METHOD AND APPARATUS FOR BEAT-SPACE FREQUENCY DOMAIN PREDICTION OF CARDIOVASCULAR DEATH AFTER ACUTE CORONARY EVENT  
A method for the machine generation of a model for predicting patient outcome following the occurrence of an event. In one embodiment the method includes the steps of obtaining a physiological...
US20140371564 METHODS AND APPARATUS FOR STIMULATING AND RECORDING NEURAL ACTIVITY  
Thermal drawing processes can be used to make multifunctional, high-resolution neural probes for neural recording and stimulation. An exemplary neural probe may include one or more conductive...
US20140370598 ARTICLES AND METHODS FOR STEM CELL DIFFERENTIATION  
Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least...
US20140369934 dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells  
The invention provides methods of identifying metakaryotic stem cells, as well as methods of identifying agents that selectively modulate the growth, migration, replication, and/or survival of...
US20140369018 POWER CONVERTERS HAVING CAPACITIVE ENERGY TRANSFER ELEMENTS AND ARRANGEMENTS OF ENERGY STORAGE ELEMENTS FOR POWER CONVERTERS  
A power converter includes a PCB and a semiconductor die coupled to the PCB. The semiconductor die includes first through fourth switching devices. The power converter further includes a first...
US20140368728 Methods and Apparatus for High Speed Camera  
In exemplary implementations of this invention, a light source illuminates a scene and a light sensor captures data about light that scatters from the scene. The light source emits multiple...
US20140367871 Multi-Stage Bubble Column Humidifier  
A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a...
US20140367558 Methods and Apparatus for High Speed Camera  
In exemplary implementations of this invention, a camera can capture multiple millions of frames per second, such that each frame is 2D image, rather than a streak. A light source in the camera...
8914505 Methods and apparatus for tuning a network for optimal performance  
In exemplary implementations of this invention, one or more computer processors receive electronic data indicative of, or compute (i) at least three different topologies of a network and (ii) a...
8912872 Clamp assembly including permanent magnets and coils for selectively magnetizing and demagnetizing the magnets  
A clamp assembly comprises a first clamp including a plurality of magnet devices. Each magnet device includes a permanent magnet and a coil surrounding the permanent magnet. The clamp assembly...
8912304 Polyol-based polymers  
The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of...
8910638 Methods and apparatus for high-throughput neural screening  
In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used...
US20140365250 TRANSPORTATION SERVICE RESERVATION METHOD AND APPARATUS  
A transportation service reservation method includes receiving a ride request specifying an origin and a destination; with respect to each of vehicles each capable of providing ride options in...
US20140364629 MICROBIAL PRODUCTION OF 3,4-DIHYDROXYBUTYRATE (3,4-DHBA), 2,3- DIHYDROXYBUTYRATE (2,3-DHBA) AND 3-HYDROXYBUTYROLACTONE (3-HBL)  
The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
US20140364368 STIMULUS RESPONSIVE NANOCOMPLEXES AND METHODS OF USE THEREOF  
The present invention provides stimulus responsive nanocomplexes comprising a masking moiety, e.g., a peptide, and a therapeutic moiety, e.g., an anti-coagulant. The invention also provides methods...
US20140364330 Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector  
The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery...
US20140363833 AFFINITY-BASED DETECTION OF LIGAND-ENCODED SYNTHETIC BIOMARKERS  
The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are...
US20140363497 Nanocell Drug Delivery System  
Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a...
US20140362088 GRAPHICAL DISPLAY OF RADAR AND RADAR-LIKE METEOROLOGICAL DATA  
Described are a method and a system for generating a weather radar display. The method includes determining proxy meteorological radar data for a first area of a geographical region for which...
US20140360880 SYSTEMS AND METHODS FOR UNIPOLAR SEPARATION OF EMULSIONS AND OTHER MIXTURES  
Embodiments discussed herein relate to systems and methods for separating two or more phases of an emulsion or other mixture. The methods include providing the mixture with a net and unipolar...
8909370 Interactive systems employing robotic companions  
An interactive system for interacting with a sentient being. The system includes a robotic companion of which the sentient being may be a user and an entity which employs the robot as a participant...
8908261 Device and method for luminescence enhancement by resonant energy transfer from an absorptive thin film  
Disclosed are a device and a method for the design and fabrication of the device for enhancing the brightness of luminescent molecules, nanostructures, and thin films. The device includes a mirror,...
8907664 Non-intrusive monitoring of power and other parameters  
Methods and apparatus for non-intrusive power monitoring and current measurement in a circuit breaker without modification of the breaker panel or the circuit breaker itself. In one example, an...
8906814 Highly reactive multilayer assembled coating of metal oxides on organic and inorganic substrates  
One aspect of the invention relates to a method of preparing metal oxide coated substrates for various potential applications, and the coated substrate formed thereby.
8906616 Engineering of systems, methods and optimized guide compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8906417 Nanostructures for drug delivery  
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the...
8906381 Immunonanotherapeutics that provide IGG humoral response without T-cell antigen  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune...
8906356 Mutant interleukin-2 (IL-2) polypeptides  
The present invention relates to mutant IL-2 polypeptides that act as receptor antagonists. The mutant IL-2 polypeptides bind CD 25 but do not activate the IL-2 receptor. Also provided are methods...
8906216 Method for producing alloy deposits and controlling the nanostructure thereof using electro-deposition with controlled polarity ratio  
Bipolar current electrodeposits a nanocrystalline grain size. Polarity Ratio relates the absolute value of time integrated amplitude of negative polarity and positive polarity current. Grain size...
8905759 Systems and methods for delivering substances into nanoporous mineralized tissues  
Methods and systems are provided for transporting a therapeutic or cosmetic substance into nanoporous mineralized tissue structures, such as teeth. The method may include contacting the nanoporous...
US20140358015 METHOD FOR ESTIMATING CHANGES OF CARDIOVASCULAR INDICES USING PERIPHEAL ARTERIAL BLOOD PRESSURE WAVEFORM  
The systems and methods described herein enable reliable estimation of cardiovascular indices on real-time, non-invasive or minimally-invasive, and heat-to-beat basis. Cardiovascular indices which...
US20140357965 SYSTEMS, DEVICES AND METHODS FOR NONINVASIVE OR MINIMALLY-INVASIVE ESTIMATION OF INTRACRANIAL PRESSURE AND CEREBROVASCULAR AUTOREGULATION  
The systems, devices, and methods described herein provide for the estimation and monitoring of cerebrovascular system properties and intracranial pressure (ICP) from one or more measurements or...
US20140357530 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, KNOCK OUT LIBRARIES AND APPLICATIONS THEREOF  
The present invention generally relates to compositions, methods applications and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other...
US20140356822 Methods and apparatus for conversation coach  
In exemplary implementations of this invention, a display screen and speakers present an audiovisual display of an animated character to a human user during a conversational period of a coaching...
US20140356445 Artificial Cell Constructs For Cellular Manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20140355322 Stacked Switched Capacitor Energy Buffer Circuit  
A stacked switched capacitor (SSC) energy buffer circuit includes a switching network and a plurality of energy storage capacitors. The switching network need operate at only a relatively low...
US20140354071 EFFICIENT NEAR-FIELD WIRELESS ENERGY TRANSFER USING ADIABATIC SYSTEM VARIATIONS  
Disclosed is a method for transferring energy wirelessly including transferring energy wirelessly from a first resonator structure to an intermediate resonator structure, wherein the coupling rate...
US20140353860 ELECTRICALLY-DRIVEN FLUID FLOW AND RELATED SYSTEMS AND METHODS, INCLUDING ELECTROSPINNING AND ELECTROSPRAYING SYSTEMS AND METHODS  
Systems and methods in which the flow of fluid is electrically driven, including electrospinning and electrospraying systems and methods, are generally described.
US20140353397 ELECTROSPRAYING SYSTEMS AND ASSOCIATED METHODS  
Electrospraying systems and associated methods are generally described.
US20140352382 MAGNETICALLY TUNABLE MICROSTRUCTURED SURFACES  
Provided in one embodiment is a dynamically tunable structure including an elastic layer, and a plurality of ferromagnetic micropillars disposed over the elastic layer. The elastic layer may have...
RE45266 Tactile sensor using elastomeric imaging  
A tactile sensor includes a photosensing structure, a volume of elastomer capable of transmitting an image, and a reflective skin covering the volume of elastomer. The reflective skin is...
8904154 Execution migration  
An execution migration approach includes bringing the computation to the locus of the data: when a memory instruction requests an address not cached by the current core, the execution context...
8903192 Noise reduction of imaging data  
The present invention relates to systems and methods for reducing noise in image data. Preferred embodiments relate to methods for analyzing two-photon in vivo imaging of biological systems. With...
8902946 Photonic crystal surface-emitting lasers enabled by an accidental Dirac point  
A photonic-crystal surface-emitting laser (PCSEL) includes a gain medium electromagnetically coupled to a photonic crystal whose energy band structure exhibits a Dirac cone of linear dispersion at...
8901084 Self-assembling peptide incorporating modifications and methods of use thereof  
The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino...
8899102 Method and apparatus for trapping single particles in microfluidic channels  
Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for...
US20140351819 MULTIPROCESSOR SCHEDULING POLICY  
A method of determining a multi-agent schedule includes defining a well-formed, non-preemptive task set that includes a plurality of tasks, with each task having at least one subtask. Each subtask...
US20140350528 SYSTEMS AND METHODS FOR DELIVERING A THERAPEUTIC AGENT  
Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a method includes providing a wearable delivery device that includes an electrochemical actuator and...
US20140350473 INTRAVESICAL DRUG DELIVERY DEVICE  
Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube...