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Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20140263060 Multi-Stage Membrane Distillation Process  
Portions of a feed liquid are passed through respective condensers and liquid-liquid heat exchangers. The feed liquid is then heated and injected into a first feed-liquid containment chamber, where...
US20140263055 Ion Sequestration for Scale Prevention in High-Recovery Desalination Systems  
Cations that can precipitate from an aqueous composition to produce scaling are sequestered by adding a multi-dentate ligand to the aqueous composition. The multi-dentate ligand bonds with the...
US20140261345 OPTIMIZED FUEL MANAGEMENT SYSTEM FOR DIRECT INJECTION ETHANOL ENHANCEMENT OF GASOLINE ENGINES  
Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. It is preferred that the direct...
8837877 Patterned non-reciprocal optical resonator  
A patterned nonreciprocal optical resonator structure is provided that includes a resonator structure that receives an optical signal. A top cladding layer is deposited on a selective portion of...
8837550 Continuous-wave organic dye lasers and methods  
An organic dye laser produces a continuous-wave (cw) output without any moving parts (e.g., without using flowing dye streams or spinning discs of solid-state dye media to prevent photobleaching)...
8836172 Efficient near-field wireless energy transfer using adiabatic system variations  
Disclosed is a method for transferring energy wirelessly including transferring energy wirelessly from a first resonator structure to an intermediate resonator structure, wherein the coupling rate...
8835342 Mesostructured zeolitic materials and methods of making and using the same  
One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for...
8835147 Cellular production of glucaric acid through recombinant expression of uronate dehydrogenase and myo-inositol oxygenase  
The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate...
8835138 Glucose valve and other metabolite valves  
Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative...
8835127 Optoelectronic detection system  
The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the...
8834885 Methods for identification of sites for IgG conjugation  
The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and...
8834696 Amplified electrokinetic fluid pumping switching and desalting  
The present invention provides a device and methods of use thereof for desalting a solution. The methods, inter-alia, make use of a device comprising microchannels, which are linked to conduits,...
8834146 System for passive alignment of surfaces  
Passive stamp alignment system. The system includes a stamp supported by a stamp holder resting on three balls affixed to a top platform. A bottom platform supports a substrate to be aligned with...
8833510 Phononic metamaterials for vibration isolation and focusing of elastic waves  
A methodology for designing structured metamaterials that can reflect, absorb and focus the propagation of both scalar acoustic and vector elastic waves is described. Three exemplary representative...
US20140258689 PROCESSOR FOR LARGE GRAPH ALGORITHM COMPUTATIONS AND MATRIX OPERATIONS  
A node processor and method for performing matrix operations includes storing, in memory, non-zero matrix elements of a first sparse matrix, non-zero matrix elements of a second sparse matrix, and...
US20140257519 Artificial Ankle-Foot System with Spring, Variable-Damping, and Series-Elastic Actuator Components  
An artificial foot and ankle joint consists of a curved leaf spring foot member having a heel extremity and a toe extremity, and a flexible elastic ankle member that connects the foot member for...
US20140257236 INJECTION METHODS USING A SERVO-CONTROLLED NEEDLE-FREE INJECTOR  
A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The...
US20140256984 DEVICES AND METHODS FOR CRYSTALLIZATION  
The invention in some aspects relates to devices and methods for nucleating crystals under controlled conditions. In some aspects of the invention, devices and methods are provided for continuous...
US20140256046 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
US20140255693 Oligocrystalline Ceramic Structures for Enhanced Shape Memory and Pseudoelastic Effects  
Shape memory and pseudoelastic martensitic behavior is enabled by a structure in which there is provided a crystalline ceramic material that is capable of undergoing a reversible martensitic...
US20140254620 High-Concentration Active Doping in Semiconductors and Semiconductor Devices Produced by Such Doping  
In a method of forming a photonic device, a first silicon electrode is formed, and then a germanium active layer is formed on the first silicon electrode while including n-type dopant atoms in the...
8830793 System and method for collision avoidance in underwater vehicles  
A system for providing collision avoidance in underwater vehicles contains a spectral analysis module for determining expectation value of acoustic (incoherent) intensity. The system also contains...
8829219 Olefin metathesis catalysts and related methods  
The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to...
8828965 MiR-150 for the treatment of blood disorders  
The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor...
8828478 Highly luminescent color-selective nanocrystalline materials  
A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.
8828335 Microfluidic bubble logic devices  
Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices,...
US20140248702 CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20140247020 Energy Extraction  
This disclosure describes techniques and systems for extracting energy from the endocochlear potential (EP) in animal subjects (e.g., human subjects) and using the extracted energy to operate...
US20140246619 DESIGN OF MULTI-ELECTRON LI-ION PHOSPHATE CATHODES BY MIXING TRANSITION METALS  
In general, the invention relates to electrode materials, e.g., novel cathode materials with high density, low cost, and high safety. A voltage design strategy based on the mixing of different...
US20140246334 SYSTEMS, DEVICES AND METHODS FOR MULTIPLEXED DIAGNOSTICS  
Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary...
US20140245946 Synthesis and Transfer of Transition Metal Disulfide Layers on Diverse Surfaces  
Aromatic molecules are seeded on a surface of a growth substrate; and a layer (e.g., a monolayer) of a metal dichalcogenide is grown via chemical vapor deposition on the growth substrate surface...
8824051 Passive louver-based daylighting system  
A daylighting system for use in a building including a louver array having a first longitudinal element, and a second longitudinal element spaced therefrom. At least one of the first and second...
8823250 High efficiency incandescent lighting  
Incandescent lighting structure. The structure includes a thermal emitter that can, but does not have to, include a first photonic crystal on its surface to tailor thermal emission coupled to, in a...
8822410 Tympanic membrane permeating ear drops and uses thereof  
The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration...
8821434 Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system  
A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the...
8821402 Systems, devices and methods for noninvasive or minimally-invasive estimation of intracranial pressure and cerebrovascular autoregulation  
The systems, devices, and methods described herein provide for the estimation and monitoring of cerebrovascular system properties and intracranial pressure (ICP) from one or more measurements or...
8820357 Microfluidic bubble logic devices and methods  
A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences...
8820143 Leak detection system  
The system includes structure for supporting at least one tube within a pipe. The tube has one end disposed close to, or in contact with, a wall of the pipe. A sensor is disposed within the at...
US20140243995 STACKED PLANAR SHEET TISSUE ENGINEERING SCAFFOLDS WITH 3D STRUCTURAL ORDER  
A three-dimensional tissue engineering scaffold device and related methods are disclosed herein. The tissue engineering scaffold includes a plurality of polymers sheets. Each polymer sheet includes...
US20140243277 Water Soluble Membrane Proteins and Methods for the Preparation and Use Thereof  
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
US20140243229 METHODS AND PRODUCTS RELATED TO GENOTYPING AND DNA ANALYSIS  
The invention encompasses methods and products related to genotyping. The method of genotyping of the invention is based on the use of single nucleotide polymorphisms (SNPs) to perform high...
US20140243207 Superconducting flat tape cable magnet  
A method for winding a coil magnet with the stacked tape cables, and a coil so wound. The winding process is controlled and various shape coils can be wound by twisting about the longitudinal axis...
US20140242700 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
US20140242699 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS  
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery...
US20140242664 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
US20140242409 ARTICLES INCORPORATING NICKEL TUNGSTEN ALLOY DEPOSITS HAVING CONTROLLED, VARYING, NANOSTRUCTURE  
Bipolar wave current, is used to electrodeposit a nanocrystalline grain size. Polarity Ratio is the ratio of absolute value of time integrated amplitude of negative and positive polarity current....
US20140240532 Methods and Apparatus for Light Field Photography  
In exemplary implementations of this invention, a light field camera uses a light field dictionary to reconstruct a 4D light field from a single photograph. The light field includes both angular...
8819272 Multiprocessor communication networks  
A parallel multiprocessor system includes a packet-switching communication network comprising a plurality of processor nodes operating concurrently in parallel. Each processor node generates...
8818723 Localization and tracking system for mobile robots  
Localization and tracking system. The system includes at least one laser mounted for pointing its beam at arbitrary locations within a three-dimensional space. An object within the...
8818150 Method and apparatus for modulation using a conductive waveguide  
Method and apparatus for modulation of both the intensity and the polarization of radiation in silicon waveguides by applying a biasing voltage to the waveguide.