Patents and Patent Applications from Massachusetts Institute of Technology MIT


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US20160243048 CATIONIC NANOPARTICLES FOR CO-DELIVERY OF NUCLEIC ACIDS AND THERAPEUTIC AGENTS  
Nanoparticles containing an aqueous core containing one or more nucleic acids, such as siRNA, and a shell containing one or more hydrophobic cationic materials, one or more amphiphilic materials,...
9425346 Methods of imprint patterning of irregular surface  
Patterned substrates for photovoltaic and other uses are made by pressing a flexible stamp upon a thin layer of resist material, which covers a substrate, such as a wafer. The resist changes phase...
9422517 Microscale and nanoscale structures for manipulating particles  
The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality...
9422409 Method of hydrolytically stable bonding of elastomers to substrates  
Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS...
9422373 Modified alginates for cell encapsulation and cell therapy  
Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The...
US20160240297 High-Temperature Superconducting High-Current Cables  
High-temperature superconducting (HTS) devices and methods are disclosed. An HTS cable subassembly has a rectangular shaped cross section. The subassembly includes a stack of tapes formed of a...
US20160240286 High-Temperature Superconducting High-Current Devices Compensated for Anisotropic Effects  
High-temperature superconducting (HTS) devices and methods are disclosed. An HTS cable subassembly has a rectangular shaped cross section. The subassembly includes a stack of tapes formed of a...
US20160239611 SYSTEM AND METHOD FOR SEPSIS CARE TASK MANAGEMENT  
Systems and methods are disclosed for sepsis care management. First data regarding a patient and second data regarding a clinician's treatment of a patient are received by at least one processor....
US20160239606 SYSTEMS AND METHODS FOR DETERMINING AN UNKNOWN CHARACTERISTIC OF A SAMPLE  
Computerized analysis methods and systems to implement the computerized analysis methods are disclosed herein. Specifically, the present disclosure relates to systems and methods for determining...
US20160238593 Pumilio Domain-based Modular Protein Architecture for RNA Binding  
A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and...
US20160238591 BIOPOLYMER-MEDIATED ASSEMBLY OF NANOPARTICLES USING GENETICALLY ENCODED PROTEINS  
Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked...
US20160238455 COMPOSITIONS AND METHODS FOR THE DOWNCONVERSION OF LIGHT  
The present invention generally relates to composition and methods for downconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a...
US20160237343 METHODS AND COMPOSITIONS FOR THE UPCONVERSION OF LIGHT  
The present invention generally relates to composition and methods for upconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a...
US20160235778 COMPOSITIONS CONTAINING PUFA, URIDINE AND CHOLINE AND METHODS OF USE THEREOF  
The invention is directed to a method for increasing phosphatidylcholine in the blood of a subject comprising administering to the subject a composition having uridine or a metabolic precursor of...
US20160235324 Methods, Systems, and Apparatus For Self-Calibrating EEG Neurofeedback  
Methods, systems, and apparatus implementing a generalizable self-calibrating protocol coupled with machine learning algorithms in an exemplary setting of classifying perceptual states as...
9419824 Digital transmitter  
An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to...
9419147 Electronically controlled squishable composite switch  
A method and apparatus for making analog and digital electronics which includes a composite including a squishable material doped with conductive particles. A microelectromechanical systems (MEMS)...
9417068 Stable three-axis nuclear spin gyroscope  
An n-NV-based gyroscope is provided that includes a diamond structure implanted with a plurality of NV centers, whose nuclear spins form a spin gyroscope. A number of radio-frequency (rf) coils...
9416800 Thermodynamic balancing of combined heat and mass exchange devices  
A carrier-gas mixture is directed through a fluid flow path in a combined heat and mass transfer device, which can be operated at sub-atmospheric pressure. Heat and mass are transferred from or to...
9415070 Methods and compositions for localized delivery of agents to virally infected cells and tissues  
The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells,...
US20160231734 Methods and Apparatus for Handheld Tool  
In exemplary implementations of this invention, a computer-assisted, handheld machining tool allows even an inexperienced user to carve a complex 3D object, while maintaining artistic freedom to...
US20160231267 DEVICES AND METHODS INCLUDING A PRECONCENTRATOR MATERIAL FOR DETECTION OF ANALYTES  
Embodiments described herein provide devices and methods for the determination of analytes. The device typically includes an absorbent material that allows for an analyte sample to be concentrated...
US20160229877 METATHESIS CATALYSTS AND METHODS THEREOF  
The present invention provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I or II. In some...
US20160229714 Hybridization of Humidification-Dehumidification and Pressure-Retarded Osmosis  
A carrier gas and a combined feed liquid are directed through a humidifier, where water vaporizes from the combined feed liquid into the carrier gas, and through a dehumidifier, where the combined...
US20160228574 PARTICLES WITH MULTIPLE FUNCTIONALIZED SURFACE DOMAINS  
This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides...
US20160228507 ISOLATED MUCINS AND DIFFERENT MICROORGANISMS, AND METHODS OF USE  
A method of altering intercellular interactions between a combination of microorganisms includes contacting a combination of different species of microorganisms with at least one mucin. Isolated...
US20160228465 Modified Saponins For the Treatment of Fungal Infections  
Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
US20160228265 ARTIFICIAL HUMAN LIMBS AND JOINTS EMPLOYING ACTUATORS, SPRINGS AND VARIABLE DAMPER ELEMENTS  
It is to be understood that the methods and apparatus which have been described above are merely illustrative applications of the principles of the invention. Numerous modifications may be made by...
9412173 Method for mapping an environment  
A method for mapping an environment comprises moving a sensor along a path from a start location (P0) through the environment, the sensor generating a sequence of images, each image associated...
9411010 System for introspection and annotation of electronic design data  
A system for introspection and annotation of electronic design data includes a tracked probe that interacts with an electronic circuit, a tracking system, schematics, design files, or models for...
9410959 Devices comprising coated semiconductor nanocrystal heterostructures  
A semiconductor nanocrystal heterostructure has a core of a first semiconductor material surrounded by an overcoating of a second semiconductor material. Upon excitation, one carrier can be...
9410142 Dendrimer-based excipients for the attenuation of protein aggregation  
One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another...
9409938 Tungsten oxo alkylidene complexes for Zselective olefin metathesis  
The current application describes tungsten oxo alkylidene complexes for olefin metathesis.
US20160227508 TRANSPONDER LOCALIZATION  
A method processes a concurrently triggered response signal at a number of transceivers configured to operate at a channel carrier frequency, where at least some of the transceivers have distinct...
US20160226210 SYSTEMS AND METHODS FOR LIGHT AMPLIFICATION  
A system for optical amplification includes an optical fiber with a core containing a gain medium surrounded by a cladding, a seed light source, a control light source, and a pump source. The seed...
US20160226095 SODIUM-CONDUCTING SOLID ELECTROLYTE  
A sodium-conductive solid-state electrolyte material includes a compound of the composition Na10MP2S12, wherein M is selected from Ge, Si, and Sn. The material may have a conductivity of at least...
US20160226072 Fluorinated Coatings for High Performance Electrodes  
Disclosed herein is an electrode material comprising a carbon-containing substrate, comprising a surface and a plurality of RF moieties wherein each RF moiety is covalently bound to the surface;...
US20160225887 CONTROL OF CURRENT COLLAPSE IN THIN PATTERNED GAN  
A GaN device is formed on a semiconductor substrate having a plurality of recessed regions formed in a surface thereof. A seed layer, optional buffer layer, and gallium nitride layer such as a...
US20160223988 Transparent Flat-Panel Holographic Display  
A flat-panel holographic video display includes a control layer and waveguide elements. Each waveguide element has a light-guiding substrate and an array of transducers configured to produce a...
US20160222050 MUTAGENIC NUCLEOSIDE ANALOGS AND USES THEREOF  
The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs are expected to show multiple tautomerism and may increase the mutation of an RNA and/or DNA (be...
US20160220727 SELF-ASSEMBLING UNDERWATER ADHESIVES  
Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an...
9407164 Systems approach to photovoltaic energy extraction  
Described is a method and apparatus for per-panel photovoltaic energy extraction with integrated converters. Also described are switched-capacitor (SC) converters have been evaluated for many...
9405124 Methods and apparatus for light field projection  
In exemplary implementations of this invention, light from a light field projector is transmitted through an angle-expanding screen to create a glasses-free, 3D display. The display can be...
9405008 Methods and apparatus for multi-frequency camera  
In exemplary implementations of this invention, a multi-frequency ToF camera mitigates the effect of multi-path interference (MPI), and can calculate an accurate depth map despite MPI. A light...
9404924 Method of performing one-step, single cell RT-PCR  
The invention provides methods for detecting virus production, determining frequency and identity of HIV reservoirs, or evaluating gene expression on a single-cell basis using microengraving and...
9404835 Microfluidic bubble logic devices  
Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices,...
9404130 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway  
The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
9403684 Compositions, methods, and systems for separating carbon-based nanostructures  
The present invention generally relates to compositions, methods, and systems for separating carbon-based nanostructures.
9403104 Multi-stage bubble-column vapor mixture condenser  
A multi-stage bubble-column vapor mixture condenser comprises at least a first stage and a second stage. Each stage includes a carrier-gas inlet and a carrier-gas outlet, as well as a condenser...
US20160218759 Digital Matching Of A Radio Frequency Antenna  
A matching technique that may be used with electrically small antennas uses one or more digital circuit blocks connected in a feedback arrangement configured to tune the transfer function response...