Sign up

Patents and Patent Applications from Massachusetts Institute of Technology MIT


Match Document Document Title
US20140050707 MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS  
The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor...
US20140049318 Method and Apparatus for High Efficiency, High Dynamic Range Digital RF Power Amplification  
A digital, radio frequency (RF) power amplifier includes first and second RF digital to analog converters (RF DACs) and a combiner to combine output signals of the first and second RF DACs. In at...
US20140048126 VIRUS FILM AS TEMPLATE FOR POROUS INORGANIC SCAFFOLDS  
Virus multilayers can be used as templates for growth of inorganic nanomaterials. For example, layer-by-layer construction of virus multilayers on functionalized surfaces form nanoporous structures...
8656244 Rate adaptive nonbinary LDPC codes with low encoding complexity  
Described herein is a method and system that provides a class of error correction codes which can be used in communication systems to correct errors which may be introduced by a communication...
8656141 Architecture and programming in a parallel processing environment with switch-interconnected processors  
An integrated circuit includes a plurality of tiles. Each tile includes a pipelined processor configured to process multiple streams of instructions for the processor; and a switch including...
8655441 Methods and apparatus for monitoring patients and delivering therapeutic stimuli  
In an exemplary implementation of this invention, a user wears comfortable biosensors. These sensors gather physiological data from the user and transmit this data to another radio-enabled device....
8655114 Hitless tuning and switching of optical resonator amplitude and phase responses  
A hitless tunable filter may include a ring resonator, a Mach-Zehnder coupler, and first and second phase shifters. The Mach-Zehnder coupler may include a switching arm that is coupled to the ring...
8654234 Bi-directional screen  
A bidirectional screen alternately switches between a display mode showing conventional graphics and a capture mode in which the LCD backlight is disabled and the LCD displays a pinhole array or a...
8653867 Pulse modulated neural integrator circuit and associated phase locked loop  
A pulse modulated neural integrator circuit is comprised of discrete analog electronic components and has a plurality of discrete stable states. In some embodiments, the pulse modulated neural...
8653818 Parallel transmission RF pulse design with local SAR constraints  
A method of designing a parallel transmission radio frequency (RF) pulse for a magnetic resonance imaging (MRI) system includes compressing a model for a subject to be scanned by the MRI system...
8652797 Methods of NAD-dependent deacetylation of a lysine residue in a protein  
Methods of NAD-dependent of at least one lysine residue in an acetylated protein are disclosed. The methods include combining the acetylated protein with an isolated Sir2 protein or fragment that...
8652332 Liquid filtration using pressure difference across a hydrophobic membrane  
Method and devices for filtering liquid are provided that rely on pressure difference to filter liquid. In one embodiment, a device for filtering liquid includes a feed chamber, a permeate chamber,...
8651678 Polarization fields for dynamic light field display  
In exemplary implementations of this invention, a flat screen device displays a 3D scene. The 3D display may be viewed by a person who is not wearing any special glasses. The flat screen device...
8651183 Robotic exploration of unknown surfaces  
The subject matter describes a tactile sensing device comprising an end effector and a control unit. The control unit is capable of receiving tactile information from the at least one end effector....
US20140046455 POWERED ARTIFICIAL KNEE WITH AGONIST-ANTAGONIST ACTUATION  
A knee prosthesis comprises an agonist-antagonist arrangement of two series-elastic actuators in parallel, including a knee joint, flexion and extension actuators connected to the joint in parallel...
US20140044770 Compositions and Methods for Modulating BRD4 Bioactivity  
Compositions and methods for increasing or decreasing DNA repair are provided. Composition includes a Brd4 polypeptide, fragment, fusion, or variant thereof. The fusion protein can include a...
US20140044340 3D Radiometry  
Methods and a computer program product for deriving temperature information with respect to surfaces within a scene that is imaged radiometrically. A time sequence of radiometric data is acquired...
US20140042890 High Efficiency Incandescent Lighting  
Incandescent lighting structure. The structure includes a thermal emitter that can, but does not have to, include a first photonic crystal on its surface to tailor thermal emission coupled to, in a...
8649086 Apparatus and method for generating high-intensity optical pulses with an enhancement cavity  
An enhancement cavity includes a plurality of focusing mirrors, at least one of which defines a central aperture having a diameter greater than 1 mm. The mirrors are configured to form an optical...
8648802 Collapsible input device  
In exemplary implementations of this invention, a handheld, collapsible input device (CID) may be employed by a user to input and manipulate 3D information. The CID telescopes in length. As a user...
8648176 Engineered proteins with high affinity for DOTA chelates  
The present invention features, inter alia, compositions and methods for the treatment of cancer and infectious disease. The compositions include engineered proteins that specifically bind a metal...
8647477 High-efficiency thermal-energy-driven water purification system  
Water can be separated from a liquid composition (e.g., salt water) by directing a carrier gas flow through an evaporator and directly contacting the carrier gas flow with the liquid composition in...
US20140039849 METHOD FOR THE CONSTRUCTION OF A WATER DISTRIBUTION MODEL  
A method for the determination of demand zones for use with a water distribution model of a water distribution network, the method comprising the steps of: constructing polygons about clusters of...
US20140037873 Digital Flexural Materials  
Digital flexural materials are kits of discrete parts that can be assembled into a lattice structure to produce functionally useful assemblies. Digital flexural materials enable design of materials...
US20140037755 Mapkap Kinase-2 as a Specific Target for Blocking Proliferation of P53-Defective Cells  
The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays...
US20140037736 Targeting of Antigen Presenting Cells With Immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
US20140037593 Tricalcium Phosphate Binding Peptides And Uses Thereof  
The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (β-TCP) bound to all or a portion of a β-TCP binding peptide and methods of use thereof.
US20140035438 Passive, Self-Tuning Energy Harvester for Extracting Energy From Rotational Motion  
Energy harvester. The harvester includes a radially extending beam having a proximal end mounted a selected distance from an axis of rotation of an object and includes a mass at its distal end. The...
US20140035077 Photovoltaic Device Including Semiconductor Nanocrystals  
A photovoltaic device includes a semiconductor nanocrystal and a charge transporting layer that includes an inorganic material. The charge transporting layer can be a hole or electron transporting...
US20140034002 Ultra-high Efficiency Alcohol Engines Using Optimized Exhaust Heat Recovery  
Engine system using alcohol Rankine heat recovery where the engine heat converts alcohol into hydrogen-rich gas which is then introduced into the engine cylinders. The engine system includes a...
8645115 Modular nucleic acid-based circuits for counters, binary operations, memory and logic  
We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for...
8644512 Mission planning interface for accessing vehicle resources  
In an aspect, the invention features a method for mission planning. The method includes displaying a graphical representation of a geographical area and displaying a graphical representation of one...
8644437 Digital compensation of a nonlinear system  
A method for digital compensation of a nonlinear system comprises identifying a plurality of circuit parameters of a nonlinear system. Each circuit parameter determines a nonlinear response of the...
8643347 Power converter with capacitive energy transfer and fast dynamic response  
A converter circuit and related techniques for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or...
8643058 Electro-optical device including nanocrystals  
An electro-optical device can include a plurality of nanocrystals positioned between a first electrode and a second electrode. The nanocrystal and at least one electrode can have a band gap offset...
8642333 Particulate delivery vehicles for embryoid bodies  
The present invention provides a vehicle for delivering various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradable polymer...
8642284 Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein  
Methods of identifying agents which alter the NAD-dependent deacetylation activity of a Sir2 protein or a fragment of a Sir2 protein are disclosed. The acetylated protein can be a nuclear protein,...
8642277 Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors  
Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a...
US20140032089 SYSTEM AND METHOD FOR PROVIDING DRIVER BEHAVIOR CLASSIFICATION AT INTERSECTIONS AND VALIDATION ON LARGE NATURALISTIC DATA SETS  
A system and method for predicting whether a vehicle will come to a stop at an intersection is provided. Generally, the system contains a memory; and a processor configured by the memory to perform...
US20140032017 INTEGRATED FRAMEWORK FOR VEHICLE OPERATOR ASSISTANCE BASED ON A TRAJECTORY PREDICTION AND THREAT ASSESSMENT  
Various types and levels of operator assistance are performed within a unified, configurable framework. A model of the device with a model of the environment and the current state of the device and...
US20140030995 Analog/Digital Co-Design Methodology to Achieve High Linearity and Low Power Dissipation in a Radio Frequency (RF) Receiver  
Receiver design techniques are provided that are capable of producing relatively efficient, linear radio frequency (RF) receivers. During a design process, components of an analog receiver chain...
US20140030816 REAGENT IMPREGNATED SWIPE FOR CHEMICAL DETECTION  
The invention is directed to a swipe with at least one ionization reagent associated with the swipe for detecting target analytes and methods of detecting the target analyte molecules that can...
US20140030788 MICROSCALE AND NANOSCALE STRUCTURES FOR MANIPULATING PARTICLES  
The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality...
US20140030752 MODULAR PLATFORM FOR MULTI-TISSUE INTEGRATED CELL CULTURE  
The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue...
US20140030697 SORTASE-MEDIATED MODIFICATION OF VIRAL SURFACE PROTEINS  
The present invention, in some aspects, provides methods, reagents, and kits for the functionalization of proteins on the surface of viral particles, for example, of bacteriophages, using...
US20140030487 Controlled Material Interface Transformation  
One aspect of the invention relates to materials and devices with interface layers with geometries which transform upon the direct or indirect application of load or displacement. The interface...
US20140030277 IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF  
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of t...
US20140029878 PARTIAL ARC HYDROSTATIC BEARING  
A hydrostatic bearing is provided that includes a plurality of bearing pads that form loading carrying areas. A plurality of compensators are coupled to the bearing pads, each compensator includes...
US20140029660 Method and Apparatus for Sparse Polynomial Equalization of RF Receiver Chains  
A radio frequency (RF) receiver includes an analog receiver chain followed by digital circuitry for reducing nonlinear distortion components within an output signal of the analog receiver chain. In...
US20140029658 Analog/Digital Co-Design Methodology to Achieve High Linearity and Low Power Dissipation in a Radio Frequency (RF) Receiver  
Receiver design techniques are provided that are capable of producing relatively efficient, linear radio frequency (RF) receivers. During a design process, components of an analog receiver chain...